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Marcin Kortylewski

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Qifang Zhang; Wang Zhang; Ravi Bhatia; Stephen Forman; Dewan Md Sakib Hossain; Claudia M Kowolik; Anna Kozlowska; Yong Liu; Sergey Nechaev; Sumanta Pal; Andrew Raubitschek; John J Rossi; Piotr Swiderski; Hua Yu; Marcin Kortylewski
TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo.
Yuelong Ma; Vinochani Pillay; Andrew J G Simpson; Piotr M Swiderski; Hua Yu; Otavia L Caballero; David A Horne; Richard Jove; Marcin Kortylewski; Claudia M Kowolik; Fook-Thean Lee; Andrew M Scott
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.
Heehyoung Lee; Jiehui Deng; Maciej Kujawski; Chunmei Yang; Yong Liu; Andreas Herrmann; Marcin Kortylewski; David Horne; George Somlo; Stephen Forman; Richard Jove; Hua Yu
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

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All Publications

2013: Qifang Zhang; Wang Zhang; Ravi Bhatia; Stephen Forman; Dewan Md Sakib Hossain; Claudia M Kowolik; Anna Kozlowska; Yong Liu; Sergey Nechaev; Sumanta Pal; Andrew Raubitschek; John J Rossi; Piotr Swiderski; Hua Yu; Marcin Kortylewski
TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo.
Blood 2013;121(8):1304-15.
2011: Yuelong Ma; Vinochani Pillay; Andrew J G Simpson; Piotr M Swiderski; Hua Yu; Otavia L Caballero; David A Horne; Richard Jove; Marcin Kortylewski; Claudia M Kowolik; Fook-Thean Lee; Andrew M Scott
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.
ACS chemical biology 2011;6(9):962-70.
2010: Heehyoung Lee; Jiehui Deng; Maciej Kujawski; Chunmei Yang; Yong Liu; Andreas Herrmann; Marcin Kortylewski; David Horne; George Somlo; Stephen Forman; Richard Jove; Hua Yu
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.
Nature medicine 2010;16(12):1421-8.
2010: Sumanta Kumar Pal; Marcin Kortylewski; Hua Yu; Robert A Figlin
Breaking through a plateau in renal cell carcinoma therapeutics: development and incorporation of biomarkers.
Molecular cancer therapeutics 2010;9(12):3115-25.
2010: Andreas Herrmann; Marcin Kortylewski; Maciej Kujawski; Chunyan Zhang; Karen Reckamp; Brian Armstrong; Lin Wang; Claudia M Kowolik; Jiehui Deng; Robert Figlin; Hua Yu
Targeting Stat3 in the myeloid compartment drastically improves the in vivo antitumor functions of adoptively transferred T cells.
Cancer research 2010;70(19):7455-64.
2009: Marcin Kortylewski; Piotr Swiderski; Andreas Herrmann; Lin Wang; Claudia Kowolik; Maciej Kujawski; Heehyoung Lee; Anna Scuto; Yong Liu; Chunmei Yang; Jiehui Deng; Harris S Soifer; Andrew Raubitschek; Stephen Forman; John J Rossi; Drew M Pardoll; Richard Jove; Hua Yu
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses.
Nature biotechnology 2009;27(10):925-32.
2009: Leying Zhang; Darya Alizadeh; Michelle Van Handel; Marcin Kortylewski; Hua Yu; Behnam Badie
Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice.
Glia 2009;57(13):1458-67.
2009: Lin Wang; Tangsheng Yi; Marcin Kortylewski; Drew M Pardoll; Defu Zeng; Hua Yu
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway.
The Journal of experimental medicine 2009;206(7):1457-64.
2009: Marcin Kortylewski; Maciej Kujawski; Andreas Herrmann; Chunmei Yang; Lin Wang; Yong Liu; Rosalba Salcedo; Hua Yu
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy.
Cancer research 2009;69(6):2497-505.
2009: Marcin Kortylewski; Hong Xin; Maciej Kujawski; Heehyoung Lee; Yong Liu; Timothy Harris; Charles G Drake; Drew M Pardoll; Hua Yu
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.
Cancer cell 2009;15(2):114-23.
2008: Maciej Kujawski; Marcin Kortylewski; Heehyoung Lee; Andreas Herrmann; Heidi Kay; Hua Yu
Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice.
The Journal of clinical investigation 2008;118(10):3367-77.
2008: Guilian Niu; Jon Briggs; Jiehui Deng; Yihong Ma; Heehyoung Lee; Marcin Kortylewski; Maciej Kujawski; Heidi Kay; W.Douglas Cress; Richard Jove; Hua Yu
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.
Molecular cancer research : MCR 2008;6(7):1099-105.
2008: Marcin Kortylewski; Hua Yu
Role of Stat3 in suppressing anti-tumor immunity.
Current opinion in immunology 2008;20(2):228-33.
2007: Timothy J Harris; Joseph Grosso; Hung-Rong Yen; Hong Xin; Marcin Kortylewski; Emilia Albesiano; Edward L Hipkiss; Derese Getnet; Monica V Goldberg; Charles H Maris; Franck Housseau; Hua Yu; Drew M Pardoll; Charles G Drake
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4313-7.
2007: Marcin Kortylewski; Hua Yu
Stat3 as a potential target for cancer immunotherapy.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(2):131-9.
2007: Hua Yu; Marcin Kortylewski; Drew M Pardoll
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.
Nature reviews. Immunology 2007;7(1):41-51.
2005: Marcin Kortylewski; Maciej Kujawski; Tianhong Wang; Sheng Wei; Shumin Zhang; Shari Pilon-Thomas; Guilian Niu; Heidi Kay; James J Mulé; William G Kerr; Richard Jove; Drew M Pardoll; Hua Yu
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity.
Nature medicine 2005;11(12):1314-21.
2005: Claudia Wellbrock; Christin Weisser; Jessica C Hassel; Petra Fischer; Jürgen Becker; Claudia S Vetter; Iris Behrmann; Marcin Kortylewski; Peter C Heinrich; Manfred Schartl
STAT5 contributes to interferon resistance of melanoma cells.
Current biology : CB 2005;15(18):1629-39.
2005: Qing Xu; Jon Briggs; Sungman Park; Guilian Niu; Marcin Kortylewski; Shumin Zhang; Tanya Gritsko; James Turkson; Heidi Kay; Gregg L Semenza; Jin Q Cheng; Richard Jove; Hua Yu
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.
Oncogene 2005;24(36):5552-60.
2005: Marcin Kortylewski; Richard Jove; Hua Yu
Targeting STAT3 affects melanoma on multiple fronts.
Cancer metastasis reviews 2005;24(2):315-27.
2005: Lyudmila Burdelya; Maciej Kujawski; Guilian Niu; Bin Zhong; Tianhong Wang; Shumin Zhang; Marcin Kortylewski; Kenneth Shain; Heidi Kay; Julie Y Djeu; William Dalton; Drew M Pardoll; Sheng Wei; Hua Yu
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):3925-31.
2004: Marcin Kortylewski; Waraporn Komyod; Maria-Elisabeth Kauffmann; Anja Bosserhoff; Peter C Heinrich; Iris Behrmann
Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals.
The Journal of investigative dermatology 2004;122(2):414-22.
2004: Tianhong Wang; Guilian Niu; Marcin Kortylewski; Lyudmila Burdelya; Kenneth Shain; Shumin Zhang; Raka Bhattacharya; Dmitry I Gabrilovich; Richard Heller; Domenico Coppola; William Dalton; Richard Jove; Drew M Pardoll; Hua Yu
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Nature medicine 2004;10(1):48-54.
2003: Marcin Kortylewski; Florian Feld; Klaus-Dieter Krüger; Gregor Bahrenberg; Richard A Roth; Hans-Georg Joost; Peter C Heinrich; Iris Behrmann; Andreas Barthel
Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism.
The Journal of biological chemistry 2003;278(7):5242-9.
2001: Markus Böhm; U Schulte; J O Funk; Michael Raghunath; Iris Behrmann; Marcin Kortylewski; Peter C Heinrich; Thorsten Kues; Thomas A Luger; Thomas Schwarz
Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity.
The Journal of investigative dermatology 2001;117(1):132-40.
2001: Marcin Kortylewski; Peter C Heinrich; M E Kauffmann; M Böhm; Andrzej mackiewicz; Iris Behrmann
Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells.
The Biochemical journal 2001;357(Pt 1):297-303.
2001: Marcin Kortylewski; Peter C Heinrich; Andrzej mackiewicz; Iris Behrmann
Cytokine-mediated growth inhibition of human melanoma cells.
Advances in experimental medicine and biology 2001;495():169-72.
2000: Iris Behrmann; Heike M Hermanns; Claude Haan; Marcin Kortylewski; Simone Radtke; J Greiser; Peter C Heinrich
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor.
European cytokine network 2000;11(3):491-2.
2000: S Thiel; Ulrike Sommer; Marcin Kortylewski; Claude Haan; Iris Behrmann; Peter C Heinrich; Lutz Graeve
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis.
FEBS letters 2000;470(1):15-9.
2000: Serge Haan; Marcin Kortylewski; Iris Behrmann; W Müller-Esterl; Peter C Heinrich; Fred Schaper
Cytoplasmic STAT proteins associate prior to activation.
The Biochemical journal 2000;345 Pt 3():417-21.
1999: Marcin Kortylewski; Peter C Heinrich; Andrzej mackiewicz; Ute Schniertshauer; U Klingmüller; K Nakajima; T Hirano; Friedemann Horn; Iris Behrmann
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1.
Oncogene 1999;18(25):3742-53.