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Joseph Luft

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TOP 3
Eric T Larson; Devaraja G Mudeppa; John R Gillespie; Natascha Mueller; Alberto J Napuli; Jennifer A Arif; Jenni Ross; Tracy L Arakaki; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Christophe Verlinde; Erkang Fan; Wesley C Van Voorhis; Frederick S Buckner; Pradipsinh K Rathod; Wim G J Hol; Ethan A Merritt
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Ethan A Merritt; Tracy L Arakaki; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Li Zhang; George Deditta; Joseph Luft; Christophe Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Mary Koszelak-Rosenblum; Adam Krol; Namrita Mozumdar; Kristin Wunsch; Adam Ferin; Eleanor Cook; Christina K Veatch; Raymond Nagel; Joseph Luft; George deTitta; Michael G Malkowski
Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins.

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All Publications

2010: Eric T Larson; Devaraja G Mudeppa; John R Gillespie; Natascha Mueller; Alberto J Napuli; Jennifer A Arif; Jenni Ross; Tracy L Arakaki; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Christophe Verlinde; Erkang Fan; Wesley C Van Voorhis; Frederick S Buckner; Pradipsinh K Rathod; Wim G J Hol; Ethan A Merritt
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
Journal of molecular biology 2010;396(5):1244-59.
2010: Ethan A Merritt; Tracy L Arakaki; Eric T Larson; Angela Kelley; Natascha Mueller; Alberto J Napuli; Li Zhang; George Deditta; Joseph Luft; Christophe Verlinde; Erkang Fan; Frank Zucker; Frederick S Buckner; Wesley C Van Voorhis; Wim G J Hol
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Molecular and biochemical parasitology 2010;169(2):95-100.
2009: Mary Koszelak-Rosenblum; Adam Krol; Namrita Mozumdar; Kristin Wunsch; Adam Ferin; Eleanor Cook; Christina K Veatch; Raymond Nagel; Joseph Luft; George deTitta; Michael G Malkowski
Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins.
Protein science : a publication of the Protein Society 2009;18(9):1828-39.
2009: W Nicholson Price; Yang Chen; Samuel K Handelman; Helen Neely; Philip Manor; Richard Karlin; Rajesh Nair; Jinfeng Liu; Michael Baran; John Everett; Saichiu N Tong; Farhad Forouhar; Swarup S Swaminathan; Thomas B Acton; Rong Xiao; Joseph Luft; Angela Lauricella; George deTitta; Burkhard Rost; Gaetano T Montelione; John F Hunt
Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data.
Nature biotechnology 2009;27(1):51-7.
2008: Edward H Snell; Ray M Nagel; Ann Wojtaszcyk; Hugh O'Neill; Jennifer L Wolfley; Joseph Luft
The application and use of chemical space mapping to interpret crystallization screening results.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 12):1240-9.
2008: Edward H Snell; Angela Lauricella; Stephen A Potter; Joseph Luft; Stacey M Gulde; Robert J Collins; Geoff Franks; Michael G Malkowski; Christian Cumbaa; Igor Jurisica; George deTitta
Establishing a training set through the visual analysis of crystallization trials. Part II: crystal examples.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 11):1131-7.
2008: Edward H Snell; Joseph Luft; Stephen A Potter; Angela Lauricella; Stacey M Gulde; Michael G Malkowski; Mary Koszelak-Rosenblum; Meriem I Said; Jennifer L Smith; Christina K Veatch; Robert J Collins; Geoff Franks; Max Thayer; Christian Cumbaa; Igor Jurisica; George deTitta
Establishing a training set through the visual analysis of crystallization trials. Part I: approximately 150,000 images.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 11):1123-30.
2008: Eric T Larson; Wei Deng; Brian Krumm; Alberto Napuli; Natascha Mueller; Wesley C Van Voorhis; Frederick S Buckner; Erkang Fan; Angela Lauricella; George deTitta; Joseph Luft; Frank Zucker; Wim G J Hol; Christophe Verlinde; Ethan A Merritt
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
Journal of molecular biology 2008;381(4):975-88.
2008: Ethan A Merritt; Margaret Holmes; Frederick S Buckner; Wesley C Van Voorhis; Erin Quartly; Eric M Phizicky; Angela Lauricella; Joseph Luft; George deTitta; Helen Neely; Frank Zucker; Wim G J Hol
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 6):474-8.
2008: Tracy L Arakaki; Frederick S Buckner; John R Gillespie; Nicholas A Malmquist; Margaret A Phillips; Oleksandr Kalyuzhniy; Joseph Luft; George deTitta; Christophe Verlinde; Wesley C Van Voorhis; Wim G J Hol; Ethan A Merritt
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Molecular microbiology 2008;68(1):37-50.
2007: Michael G Malkowski; Erin Quartley; Alan E Friedman; Julie Babulski; Yoshiko Kon; Jennifer Wolfley; Meriem Said; Joseph Luft; Eric M Phizicky; George deTitta; Elizabeth J Grayhack
Blocking S-adenosylmethionine synthesis in yeast allows selenomethionine incorporation and multiwavelength anomalous dispersion phasing.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6678-83.
2007: Joseph Luft; Jennifer R Wolfley; Meriem I Said; Raymond M Nagel; Angela Lauricella; Jennifer L Smith; Max H Thayer; Christina K Veatch; Edward H Snell; Michael G Malkowski; George deTitta
Efficient optimization of crystallization conditions by manipulation of drop volume ratio and temperature.
Protein science : a publication of the Protein Society 2007;16(4):715-22.
2007: Tracy Arakaki; Helen Neely; Erica Boni; Natasha Mueller; Frederick S Buckner; Wesley C Van Voorhis; Angela Lauricella; George deTitta; Joseph Luft; Wim G J Hol; Ethan A Merritt
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 3):178-82.
2006: Jürgen Bosch; Mark A Robien; Christopher Mehlin; Erica Boni; Aaron Riechers; Frederick S Buckner; Wesley C Van Voorhis; Peter J Myler; Elizabeth A Worthey; George deTitta; Joseph Luft; Angela Lauricella; Stacey Gulde; Lori A Anderson; Oleksandr Kalyuzhniy; Helen M Neely; Jenni Ross; Thomas N Earnest; Michael Soltis; Lori Schoenfeld; Frank Zucker; Ethan A Merritt; Erkang Fan; Christophe Verlinde; Wim G J Hol
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
Journal of medicinal chemistry 2006;49(20):5939-46.
2006: Margaret A Holmes; Frederick S Buckner; Wesley C Van Voorhis; Christophe Verlinde; Christopher Mehlin; Erica Boni; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W Schoenfeld; Thomas N Earnest; Wim G J Hol; Ethan A Merritt
Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 5):427-31.
2006: Mark A Robien; Jürgen Bosch; Frederick S Buckner; Wesley C Van Voorhis; Elizabeth A Worthey; Peter J Myler; Christopher Mehlin; Erica Boni; Oleksandr Kalyuzhniy; Lori Anderson; Angela Lauricella; Stacey Gulde; Joseph Luft; George deTitta; Jonathan M Caruthers; Keith O Hodgson; Michael Soltis; Frank Zucker; Christophe Verlinde; Ethan A Merritt; Lori W Schoenfeld; Wim G J Hol
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.
Proteins 2006;62(3):570-7.
2006: Margaret A Holmes; Frederick S Buckner; Wesley C Van Voorhis; Christopher Mehlin; Erica Boni; Thomas N Earnest; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Frank Zucker; Lori W Schoenfeld; Wim G J Hol; Ethan A Merritt
Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):180-5.
2006: Tracy Arakaki; Isolde Le Trong; Eric M Phizicky; Erin Quartley; George deTitta; Joseph Luft; Angela Lauricella; Lori Anderson; Oleksandr Kalyuzhniy; Elizabeth A Worthey; Peter J Myler; David Kim; David Baker; Wim G J Hol; Ethan A Merritt
Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 3):175-9.
2006: Jonathan M Caruthers; Jürgen Bosch; Frederick S Buckner; Wesley C Van Voorhis; Peter J Myler; Elizabeth A Worthey; Christopher Mehlin; Erica Boni; George deTitta; Joseph Luft; Angela Lauricella; Oleksandr Kalyuzhniy; Lori Anderson; Frank Zucker; Michael Soltis; Wim G J Hol
Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum.
Proteins 2006;62(2):338-42.
2005: Jonathan M Caruthers; Frank Zucker; Elizabeth A Worthey; Peter J Myler; Frederick S Buckner; Wes Van Voorhuis; Christopher Mehlin; Erica Boni; Tiffany Feist; Joseph Luft; Stacey Gulde; Angela Lauricella; Oleksandr Kaluzhniy; Lori Anderson; Isolde Le Trong; Margaret A Holmes; Thomas N Earnest; Michael Soltis; Keith O Hodgson; Wim G J Hol; Ethan A Merritt
Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.
Protein science : a publication of the Protein Society 2005;14(11):2887-94.
2005: Claudia Schnick; Mark A Robien; Andrzej M Brzozowski; Eleanor J Dodson; Garib N Murshudov; Lori Anderson; Joseph Luft; Christopher Mehlin; Wim G J Hol; James A Brannigan; Anthony J Wilkinson
Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 9):1245-54.
2005: Vivian Cody; Joseph Luft; Walter Pangborn
Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 2):147-55.
2004: Vivian Cody; Joseph Luft; Walter Pangborn; Aleem Gangjee; Sherry F Queener
Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):646-55.
2003: Christian A Cumbaa; Angela Lauricella; Nancy Fehrman; Christina Veatch; Robert Collins; Joseph Luft; George deTitta; Igor Jurisica
Automatic classification of sub-microlitre protein-crystallization trials in 1536-well plates.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 9):1619-27.
2003: Vivian Cody; Joseph Luft; Walter Pangborn; Aleem Gangjee
Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 9):1603-9.
2003: Joseph Luft; Robert J Collins; Nancy A Fehrman; Angela Lauricella; Christina K Veatch; George deTitta
A deliberate approach to screening for initial crystallization conditions of biological macromolecules.
Journal of structural biology 2003;142(1):170-9.
2003: Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; Aleem Gangjee
Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 4):654-61.
2002: Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; Sherry F Queener; Aleem Gangjee
Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 9):1393-9.
2002: Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; Andre Rosowsky; Sherry F Queener
Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 6 Pt 2):946-54.
2001: Nikolai Galitsky; Vivian Cody; Andrzej Wojtczak; D Ghosh; Joseph Luft; Walter Pangborn; L English
Structure of the insecticidal bacterial delta-endotoxin Cry3Bb1 of Bacillus thuringiensis.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 8):1101-9.
2001: Andrzej Wojtczak; Vivian Cody; Joseph Luft; Walter Pangborn
Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 8):1061-70.
2001: T Muzioł; Vivian Cody; Joseph Luft; Walter Pangborn; Andrzej Wojtczak
Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution.
Acta biochimica Polonica 2001;48(4):877-84.
2000: Vivian Cody; D Chan; Nikolai Galitsky; D Rak; Joseph Luft; Walter Pangborn; Sherry F Queener; Charles A Laughton; M F Stevens
Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate.
Biochemistry 2000;39(13):3556-64.
1999: Joseph Luft; George deTitta
A method to produce microseed stock for use in the crystallization of biological macromolecules.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 5):988-93.
1999: Vivian Cody; Nikolai Galitsky; D Rak; Joseph Luft; Walter Pangborn; Sherry F Queener
Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
Biochemistry 1999;38(14):4303-12.
1998: Aleem Gangjee; A P Vidwans; A Vasudevan; Sherry F Queener; Roy L Kisliuk; Vivian Cody; R Li; Nikolai Galitsky; Joseph Luft; Walter Pangborn
Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents.
Journal of medicinal chemistry 1998;41(18):3426-34.
1998: Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; RL Blakley; Aleem Gangjee
Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.
Anti-cancer drug design 1998;13(4):307-15.
1998: Aleem Gangjee; X Guo; Sherry F Queener; Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn
Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines.
Journal of medicinal chemistry 1998;41(8):1263-71.
1997: Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; Andre Rosowsky; RL Blakley
Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523.
Biochemistry 1997;36(45):13897-903.
1997: Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; Aleem Gangjee; R Devraj; Sherry F Queener; RL Blakley
Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 6):638-49.
1997: Joseph Luft; George deTitta
Kinetic aspects of macromolecular crystallization.
Methods in enzymology 1997;276():110-31.
1996: Joseph Luft; D T Albright; J K Baird; George deTitta
The rate of water equilibration in vapor-diffusion crystallizations: dependence on the distance from the droplet to the reservoir.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 6):1098-106.
1996: A Wojtczak; Vivian Cody; Joseph Luft; Walter Pangborn
Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 4):758-65.
1995: George deTitta; Joseph Luft
Rate of water equilibration in vapor-diffusion crystallization: dependence on the residual pressure of air in the vapor space.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):786-91.
1995: Joseph Luft; George deTitta
Chaperone salts, polyethylene glycol and rates of equilibration in vapor-diffusion crystallization.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):780-5.
1995: S V Arakali; Joseph Luft; George deTitta
Non-ideality of aqueous solutions of polyethylene glycol: consequences for its use as a macromolecular crystallizing agent in vapor-diffusion experiments.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 5):772-9.
1995: W S Lewis; Vivian Cody; Nikolai Galitsky; Joseph Luft; Walter Pangborn; S K Chunduru; H Trent Spencer; J R Appleman; RL Blakley
Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
The Journal of biological chemistry 1995;270(10):5057-64.
1994: S V Arakali; S Easley; Joseph Luft; George deTitta
Time courses of equilibration for ammonium sulfate, sodium chloride and magnesium sulfate heptahydrate in the Z/3 crystallization plate.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):472-8.
1994: S K Chunduru; Vivian Cody; Joseph Luft; Walter Pangborn; J R Appleman; RL Blakley
Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions.
The Journal of biological chemistry 1994;269(13):9547-55.
1993: A Wojtczak; Joseph Luft; Vivian Cody
Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex.
The Journal of biological chemistry 1993;268(9):6202-6.
1992: Vivian Cody; Joseph Luft; E Ciszak; T I Kalman; J H Freisheim
Crystal structure determination at 2.3 A of recombinant human dihydrofolate reductase ternary complex with NADPH and methotrexate-gamma-tetrazole.
Anti-cancer drug design 1992;7(6):483-91.
1992: Vivian Cody; Joseph Luft; E Jensen; Walter Pangborn; L English
Purification and crystallization of insecticidal delta-endotoxin CryIIIB2 from Bacillus thuringiensis.
Proteins 1992;14(2):324.
1992: E Ciszak; Vivian Cody; Joseph Luft
Crystal structure determination at 2.3-A resolution of human transthyretin-3',5'-dibromo-2',4,4',6-tetrahydroxyaurone complex.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6644-8.
1992: Vivian Cody; Joseph Luft; Walter Pangborn; J Toy; Andrew L Bognar
Purification and crystallization of Lactobacillus casei folylpolyglutamate synthetase expressed in Escherichia coli.
Journal of molecular biology 1992;224(4):1179-80.
1992: A Wojtczak; Joseph Luft; Vivian Cody
Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin.
The Journal of biological chemistry 1992;267(1):353-7.
1989: Vivian Cody; Joseph Luft
Structure-activity relationships of antiarrhythmic agents: crystal structure of amiodarone hydrochloride and two derivatives, and their conformational comparison with thyroxine.
Acta crystallographica. Section B, Structural science 1989;45 ( Pt 2)():172-8.