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David Azorsa

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RNA Interference

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Publications

TOP 3
Meredith C Henderson; David Azorsa
High-throughput RNAi screening for the identification of novel targets.
Laura Marlow; Honey V Reddi; Stephen D Rohl; Robert C Smallridge; Peter Storz; Han Tun; Christina A von Roemeling; Yilin Zhang; Shilpi Arora; David Azorsa; Simon J Cooper; Heike R Döppler; Irma M Gonzales; John A Copland
Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.
Raoul Tibes; Hongwei H Yin; Shilpi Arora; James M Bogenberger; Esteban Braggio; Megan E Buechel; Leena Chaudhuri; Donald Chow; Tim Demuth; Irma M Gonzales; R Tanner Hagelstrom; Ruben A Mesa; James Slack; David Azorsa
RNAi screening of the kinome with cytarabine in leukemias.

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All Publications

2013: Meredith C Henderson; David Azorsa
High-throughput RNAi screening for the identification of novel targets.
Methods in molecular biology (Clifton, N.J.) 2013;986():89-95.
2012: Laura Marlow; Honey V Reddi; Stephen D Rohl; Robert C Smallridge; Peter Storz; Han Tun; Christina A von Roemeling; Yilin Zhang; Shilpi Arora; David Azorsa; Simon J Cooper; Heike R Döppler; Irma M Gonzales; John A Copland
Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.
Journal of cell science 2012;125(Pt 18):4253-63.
2012: Raoul Tibes; Hongwei H Yin; Shilpi Arora; James M Bogenberger; Esteban Braggio; Megan E Buechel; Leena Chaudhuri; Donald Chow; Tim Demuth; Irma M Gonzales; R Tanner Hagelstrom; Ruben A Mesa; James Slack; David Azorsa
RNAi screening of the kinome with cytarabine in leukemias.
Blood 2012;119(12):2863-72.
2012: Sara Byron; Galen Hostetter; David Azorsa; Tanya H Little; Elizabeth Min; Coya Tapia; Tanya S Thal; Aprill T Watanabe; SuWon Kim
Negative regulation of NF-κB by the ING4 tumor suppressor in breast cancer.
PloS one 2012;7(10):e46823.
2012: Meredith C Henderson; David Azorsa
The genomic and proteomic content of cancer cell-derived exosomes.
Frontiers in oncology 2012;2():38.
2011: Meredith C Henderson; Spyro Mousses; Jeffrey M. Trent; Daniel Von Hoff; Shilpi Arora; Ashish Choudhary; Irma M Gonzales; David Azorsa
High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.
Molecular cancer research : MCR 2011;9(6):724-32.
2011: Christian Ruiz; David R Holz; Martin Oeggerli; Sandra Schneider; Irma M Gonzales; Jeffrey M Kiefer; Tobias Zellweger; Alexander Bachmann; Pasi A Koivisto; Heikki J Helin; Spyro Mousses; Michael T Barrett; David Azorsa; Lukas Bubendorf
Amplification and overexpression of vinculin are associated with increased tumour cell proliferation and progression in advanced prostate cancer.
The Journal of pathology 2011;223(4):543-52.
2011: Sevtap Savas; David Azorsa; Hamdi Jarjanazi; Irada Ibrahim-Zada; Irma M Gonzales; Shilpi Arora; Meredith C Henderson; Yun Hee Choi; Laurent Briollais; Hilmi Ozcelik; Sukru Tuzmen
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.
PloS one 2011;6(4):e18306.
2011: Sukru Tuzmen; Pinar Tuzmen; Shilpi Arora; Spyro Mousses; David Azorsa
RNAi-based functional pharmacogenomics.
Methods in molecular biology (Clifton, N.J.) 2011;700():271-90.
2010: Laura A Marlow; Jaclyn D'Innocenzi; Yilin Zhang; Stephen D Rohl; Simon J Cooper; Thomas Sebo; Clive Grant; Bryan McIver; Jan L Kasperbauer; J Trad Wadsworth; John D Casler; Pamela W Kennedy; W Edward Highsmith; Orlo Clark; Dragana Milosevic; Brian Netzel; Kendall Cradic; Shilpi Arora; Christian Beaudry; Stefan K Grebe; Marc L Silverberg; David Azorsa; Robert C Smallridge; John A Copland
Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target.
The Journal of clinical endocrinology and metabolism 2010;95(12):5338-47.
2010: Shilpi Arora; Kristen M Bisanz; Lourdes A Peralta; Gargi D Basu; Ashish Choudhary; Raoul Tibes; David Azorsa
RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells.
Gynecologic oncology 2010;118(3):220-7.
2010: Liang Cao; Yunkai Yu; Sven Bilke; Robert L Walker; Linnia H Mayeenuddin; David Azorsa; Fan Yang; Marbin Pineda; Lee Helman; Paul S Meltzer
Genome-wide identification of PAX3-FKHR binding sites in rhabdomyosarcoma reveals candidate target genes important for development and cancer.
Cancer research 2010;70(16):6497-508.
2010: Shilpi Arora; Christian Beaudry; Kristen M Bisanz; Chao Sima; Jeff Kiefer; David Azorsa
A high-content RNAi-screening assay to identify modulators of cholesterol accumulation in Niemann-Pick type C cells.
Assay and drug development technologies 2010;8(3):295-320.
2010: Christine Kaiser; Nathanlie Meurice; Irma M Gonzales; Shilpi Arora; Christian Beaudry; Kristen M Bisanz; Alexander C Robeson; Joachim Petit; David Azorsa
Chemogenomic analysis identifies Macbecin II as a compound specific for SMAD4-negative colon cancer cells.
Chemical biology & drug design 2010;75(4):360-8.
2010: Rodger E Tiedemann; Yuan Xiao Zhu; Jessica Schmidt; Holly Yin; Chang-Xin Shi; Qiang Que; Gargi Basu; David Azorsa; Louise M Perkins; Esteban Braggio; Rafael Fonseca; P Leif Bergsagel; Spyro Mousses; A Keith Stewart
Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.
Blood 2010;115(8):1594-604.
2010: Shilpi Arora; Irma M Gonzales; R Tanner Hagelstrom; Christian Beaudry; Ashish Choudhary; Chao Sima; Raoul Tibes; Spyro Mousses; David Azorsa
RNAi phenotype profiling of kinases identifies potential therapeutic targets in Ewing's sarcoma.
Molecular cancer 2010;9():218.
2010: David Azorsa; RiLee H Robeson; Danielle Frost; Bessie Meec hoovet; Gillian R Brautigam; Chad Dickey; Christian Beaudry; Gargi D Basu; David R Holz; Joseph A Hernandez; Kristen M Bisanz; Leslie Gwinn; Andrew Grover; Joseph Rogers; Eric Reiman; Michael Hutton; Dietrich A Stephan; Spyro Mousses; Travis Dunckley
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.
BMC genomics 2010;11():25.
2009: David Azorsa; Irma M Gonzales; Gargi D Basu; Ashish Choudhary; Shilpi Arora; Kristen M Bisanz; Jeff Kiefer; Meredith C Henderson; Jeffrey M. Trent; Daniel Von Hoff; Spyro Mousses
Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer.
Journal of translational medicine 2009;7():43.
2008: Gargi D Basu; David Azorsa; Jeff Kiefer; Angela M Rojas; Sukru Tuzmen; Michael T Barrett; Jeffrey M. Trent; Olli Kallioniemi; Spyro Mousses
Functional evidence implicating S100P in prostate cancer progression.
International journal of cancer. Journal international du cancer 2008;123(2):330-9.
2007: Riina Kuuselo; Kimmo Savinainen; David Azorsa; Gargi D Basu; Ritva Karhu; Sukru Tuzmen; Spyro Mousses; Anne Kallioniemi
Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification.
Cancer research 2007;67(5):1943-9.
2005: Alessandro Lugli; Hanspeter Spichtin; Robert Maurer; Martina Mirlacher; Jeff Kiefer; Pia Huusko; David Azorsa; Luigi Terracciano; Guido Sauter; Olli Kallioniemi; Spyro Mousses; Luigi Tornillo
EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(18):6450-8.
2004: Pia Huusko; Damaris Ponciano-Jackson; Maija Wolf; Jeff Kiefer; David Azorsa; Sukru Tuzmen; Don Weaver; Christiane Robbins; Tracy Y Moses; Minna Allinen; Sampsa Hautaniemi; Yidong Chen; Abdel G Elkahloun; Mark Basik; G Steven Bova; Lukas Bubendorf; Alessandro Lugli; Guido Sauter; Johanna Schleutker; Hilmi Ozcelik; Sabine Elowe; Tony Pawson; Jeffrey M. Trent; John D Carpten; Olli Kallioniemi; Spyro Mousses
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer.
Nature genetics 2004;36(9):979-83.
2003: Sarah L Anzick; David Azorsa; S Stoney Simons; Paul S Meltzer
Phenotypic alterations in breast cancer cells overexpressing the nuclear receptor co-activator AIB1.
BMC cancer 2003;3():22.
2003: Young-Hwa Goo; Young-Chang Sohn; Dae-Hwan Kim; Seung-Whan Kim; Min-Jung Kang; Dongju Jung; Eunyee Kwak; Nickolai A Barlev; Shelley L Berger; Vincent T Chow; Robert G Roeder; David Azorsa; Paul S Meltzer; Pan-Gil Suh; Eun Joo Song; Kong-Joo Lee; Young Chul Lee; Jae Woon Lee
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.
Molecular and cellular biology 2003;23(1):140-9.
2001: David Azorsa; Heather Cunliffe; Paul S Meltzer
Association of steroid receptor coactivator AIB1 with estrogen receptor-alpha in breast cancer cells.
Breast cancer research and treatment 2001;70(2):89-101.
2000: M K Tikkanen; D J Carter; A M Harris; H M Le; David Azorsa; Paul S Meltzer; F E Murdoch
Endogenously expressed estrogen receptor and coactivator AIB1 interact in MCF-7 human breast cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12536-40.
2000: Adrian Higginbottom; I Wilkinson; B McCullough; F Lanza; David Azorsa; Lynda J Partridge; Peter N Monk
Antibody cross-linking of human CD9 and the high-affinity immunoglobulin E receptor stimulates secretion from transfected rat basophilic leukaemia cells.
Immunology 2000;99(4):546-52.
2000: Catherine Ravanat; Monique Freund; Pierre Mangin; David Azorsa; C Schwartz; Sylvie Moog; Sandrine Schuhler; J Dambach; Jean-Pierre Cazenave; François Lanza
GPV is a marker of in vivo platelet activation--study in a rat thrombosis model.
Thrombosis and haemostasis 2000;83(2):327-33.
2000: C Klein-Soyer; David Azorsa; J P Cazenave; F Lanza
CD9 participates in endothelial cell migration during in vitro wound repair.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):360-9.
1999: Sang Kook Lee; Sarah L Anzick; JE Choi; L Bubendorf; XY Guan; Yong-Keun Jung; Olli Kallioniemi; Juha Kononen; Jeffrey M. Trent; David Azorsa; Byung Hak Jhun; J H Cheong; Young Chul Lee; Paul S Meltzer; Jae Woon Lee
A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
The Journal of biological chemistry 1999;274(48):34283-93.
1999: Javed Khan; Michael Bittner; Lao H Saal; U Teichmann; David Azorsa; Gerald C Gooden; William J Pavan; Jeffrey M. Trent; Paul S Meltzer
cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13264-9.
1999: David Azorsa; Sylvie Moog; Jean-Pierre Cazenave; François Lanza
A general approach to the generation of monoclonal antibodies against members of the tetraspanin superfamily using recombinant GST fusion proteins.
Journal of immunological methods 1999;229(1-2):35-48.
1999: David Azorsa; Paul S Meltzer
Production and characterization of monoclonal antibodies to the steroid receptor coactivator AIB1.
Hybridoma 1999;18(3):281-7.
1999: V Serru; François Le Naour; Martine Billard; David Azorsa; F Lanza; Claude Boucheix; Eric Rubinstein
Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.
The Biochemical journal 1999;340 ( Pt 1)():103-11.
1999: David Azorsa; Sylvie Moog; Catherine Ravanat; Sandrine Schuhler; G Folléa; Jean-Pierre Cazenave; François Lanza
Measurement of GPV released by activated platelets using a sensitive immunocapture ELISA--its use to follow platelet storage in transfusion.
Thrombosis and haemostasis 1999;81(1):131-8.
1998: Arnaud Scherberich; Sylvie Moog; G Haan-Archipoff; David Azorsa; François Lanza; Alain Beretz
Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(11):1691-7.
1997: Sarah L Anzick; Juha Kononen; RL Walker; David Azorsa; MM Tanner; XY Guan; Guido Sauter; Olli Kallioniemi; Jeffrey M. Trent; Paul S Meltzer
AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.
Science (New York, N.Y.) 1997;277(5328):965-8.
1997: Catherine Ravanat; M Morales; David Azorsa; Sylvie Moog; Sandrine Schuhler; P Grunert; D Loew; Alain Van Dorsselaer; Jean-Pierre Cazenave; François Lanza
Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage.
Blood 1997;89(9):3253-62.
1997: C Brisson; David Azorsa; L K Jennings; Sylvie Moog; Jean-Pierre Cazenave; F Lanza
Co-localization of CD9 and GPIIb-IIIa (alpha IIb beta 3 integrin) on activated platelet pseudopods and alpha-granule membranes.
The Histochemical journal 1997;29(2):153-65.
1997: S Löffler; F Lottspeich; F Lanza; David Azorsa; Volker ter Meulen; Jürgen Schneider-Schaulies
CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus.
Journal of virology 1997;71(1):42-9.
1991: David Azorsa; J A Hyman; James E K Hildreth
CD63/Pltgp40: a platelet activation antigen identical to the stage-specific, melanoma-associated antigen ME491.
Blood 1991;78(2):280-4.
1991: James E K Hildreth; D Derr; David Azorsa
Characterization of a novel self-associating Mr 40,000 platelet glycoprotein.
Blood 1991;77(1):121-32.