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Reto Brun

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Chemicals & Drugs

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Inhibitory Concentration 50

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TOP 3
Gerhard Bringmann; Reto Brun; Tobias Büttner; Thomas Kupfer; Gabi Bauckmann; Holger Braunschweig; Guoliang Zhang; Virima Mudogo
Jozimine A2: the first dimeric Dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity.
Fahimeh Moradi-Afrapoli; Farsad Nadjafi; Melanie Raith; Martin Smiesko; Stefanie Zimmermann; Reto Brun; Samad Nejad Ebrahimi; Matthias Hamburger
Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD.
Sven Hobbie; Marcel Kaiser; Sebastian Schmidt; Dmitri Shcherbakov; Tanja Janusic; Reto Brun; Erik C Böttger
Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma.

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All Publications

2013: Gerhard Bringmann; Reto Brun; Tobias Büttner; Thomas Kupfer; Gabi Bauckmann; Holger Braunschweig; Guoliang Zhang; Virima Mudogo
Jozimine A2: the first dimeric Dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2013;19(3):916-23.
2013: Fahimeh Moradi-Afrapoli; Farsad Nadjafi; Melanie Raith; Martin Smiesko; Stefanie Zimmermann; Reto Brun; Samad Nejad Ebrahimi; Matthias Hamburger
Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD.
Phytochemistry 2013;85():143-52.
2011: Sven Hobbie; Marcel Kaiser; Sebastian Schmidt; Dmitri Shcherbakov; Tanja Janusic; Reto Brun; Erik C Böttger
Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma.
PLoS neglected tropical diseases 2011;5(5):e1161.
2011: Gerhard Bringmann; Barbara Hertlein-Amslinger; Inga Kajahn; Michael Dreyer; Reto Brun; Heidrun Moll; August Stich; Karine Ndjoko Ioset; Werner Schmitz; Luu Hoang Ngoc
Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities.
Phytochemistry 2011;72(1):89-93.
2011: Hasan Kirmizibekmez; Irem Atay; Marcel Kaiser; Reto Brun; Michelle M Cartagena; Néstor M Carballeira; Erdem Yesilada; Deniz Tasdemir
Antiprotozoal activity of Melampyrum arvense and its metabolites.
Phytotherapy research : PTR 2011;25(1):142-6.
2010: Deniz Tasdemir; David Sanabria; Ina L Lauinger; Alice Tarun; Rob Herman; Remo Perozzo; Mire Zloh; Stefan Kappe; Reto Brun; Néstor M Carballeira
2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.
Bioorganic & medicinal chemistry 2010;18(21):7475-85.
2010: Gerhard Bringmann; Sebastian K Bischof; Steffen Müller; Tanja Gulder; Christian Winter; August Stich; Heidrun Moll; Marcel Kaiser; Reto Brun; Jan Dreher; Knut Baumann
QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids.
European journal of medicinal chemistry 2010;45(11):5370-83.
2010: Minjuan Xu; Torsten Bruhn; Barbara Hertlein; Reto Brun; August Stich; Jun Wu; Gerhard Bringmann
Shuangancistrotectorines A-E, dimeric naphthylisoquinoline alkaloids with three chiral biaryl axes from the Chinese plant Ancistrocladus tectorius.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(14):4206-16.
2010: Ilkay Orhan; Bilge Sener; Marcel Kaiser; Reto Brun; Deniz Tasdemir
Inhibitory activity of marine sponge-derived natural products against parasitic protozoa.
Marine drugs 2010;8(1):47-58.
2009: Sabine Kuettel; Marc Mosimann; Pascal Mäser; Marcel Kaiser; Reto Brun; Leonardo Scapozza; Remo Perozzo
Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics.
PLoS neglected tropical diseases 2009;3(8):e506.
2009: Kennedy Nyongbela; Karine Ioset Ndjoko; Reto Brun; Sergio Wittlin; James Mbah; Felix Makolo; Marc Akam; Claire Wirmum; Simon Efange; Kurt Hostettmann
Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae).
Natural product communications 2009;4(1):5-8.
2008: Gerhard Bringmann; Stefan Rüdenauer; Andreas Irmer; Torsten Bruhn; Reto Brun; Tanja Heimberger; Thorsten Stühmer; Ralf Bargou; Manik Chatterjee
Antitumoral and antileishmanial dioncoquinones and ancistroquinones from cell cultures of Triphyophyllum peltatum (Dioncophyllaceae) and Ancistrocladus abbreviatus (Ancistrocladaceae).
Phytochemistry 2008;69(13):2501-9.
2008: Deniz Tasdemir; Reto Brun; Scott Franzblau; Yükselen Sezgin; Ihsan Calis
Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2008;15(3):209-15.
2008: Gerhard Bringmann; Joanna Spuziak; Johan Faber; Tobias A M Gulder; Inga Kajahn; Michael Dreyer; Günther Heubl; Reto Brun; Virima Mudogo
Six naphthylisoquinoline alkaloids and a related benzopyranone from a Congolese Ancistrocladus species related to Ancistrocladus congolensis.
Phytochemistry 2008;69(4):1065-75.
2008: Gerhard Bringmann; Joan Mutanyatta-Comar; Katja Maksimenka; John M Wanjohi; Matthias Heydenreich; Reto Brun; Werner E G Müller; Martin G Peter; Jacob O Midiwo; Abiy Yenesew
Joziknipholones A and B: the first dimeric phenylanthraquinones, from the roots of Bulbine frutescens.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(5):1420-9.
2008: Gerhard Bringmann; Reto Brun; Marcel Kaiser; Stefan Neumann
Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids.
European journal of medicinal chemistry 2008;43(1):32-42.
2007: Gerhard Bringmann; Christian M Gampe; Yanina Reichert; Torsten Bruhn; Johan Faber; Martin Mikyna; Matthias Reichert; Joachim Grötzinger; Reto Brun; Christoph Gelhaus
Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines.
Journal of medicinal chemistry 2007;50(24):6104-15.
2007: Sabine Kuettel; Alfonso Zambon; Marcel Kaiser; Reto Brun; Leonardo Scapozza; Remo Perozzo
Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.
Journal of medicinal chemistry 2007;50(23):5833-9.
2007: Deniz Tasdemir; Bülent Topaloglu; Remo Perozzo; Reto Brun; Rosann O'Neill; Néstor M Carballeira; Xujie Zhang; Peter J Tonge; Anthony Linden; Peter Rüedi
Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
Bioorganic & medicinal chemistry 2007;15(21):6834-45.
2007: Anastasia Karioti; Helen Skaltsa; Anthony Linden; Remo Perozzo; Reto Brun; Deniz Tasdemir
Anthecularin: a novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity.
The Journal of organic chemistry 2007;72(21):8103-6.
2007: Anne-Emmanuelle Hay; Jean-Robert Ioset; Kouassi Maximin Ahua; Drissa Diallo; Reto Brun; Kurt Hostettmann
Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.
Journal of natural products 2007;70(1):9-13.
2006: Gerhard Bringmann; Inga Kajahn; Matthias Reichert; Sarah E H Pedersen; Johan Faber; Tobias A M Gulder; Reto Brun; S Brøgger Christensen; Alicia Ponte-Sucre; Heidrun Moll; Günther Heubl; Virima Mudogo
Ancistrocladinium A and B, the first N,C-coupled naphthyldihydroisoquinoline alkaloids, from a Congolese ancistrocladus species.
The Journal of organic chemistry 2006;71(25):9348-56.
2006: Deniz Tasdemir; Reto Brun; Vanessa Yardley; Scott Franzblau; Peter Rüedi
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies.
Chemistry & biodiversity 2006;3(11):1230-7.
2006: Ihsan Caliş; Semra Koyunoğlu; Akgül Yeşilada; Reto Brun; Peter Rüedi; Deniz Taşdemir
Antitrypanosomal cycloartane glycosides from Astragalus baibutensis.
Chemistry & biodiversity 2006;3(8):923-9.
2006: Deniz Tasdemir; Gabriela Lack; Reto Brun; Peter Rüedi; Leonardo Scapozza; Remo Perozzo
Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.
Journal of medicinal chemistry 2006;49(11):3345-53.
2006: Ilkay Orhan; Bilge Sener; T Atici; Reto Brun; Remo Perozzo; Deniz Tasdemir
Turkish freshwater and marine macrophyte extracts show in vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2006;13(6):388-93.
2006: Deniz Tasdemir; Marcel Kaiser; Reto Brun; Vanessa Yardley; Thomas Schmidt; Fatma Tosun; Peter Rüedi
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies.
Antimicrobial agents and chemotherapy 2006;50(4):1352-64.
2005: Meltem Ozipek; Ali A Dönmez; Ihsan Caliş; Reto Brun; Peter Rüedi; Deniz Tasdemir
Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius.
Phytochemistry 2005;66(10):1168-73.
2005: Gerhard Bringmann; Michael Dreyer; Hélène Kopff; Heiko Rischer; Michael Wohlfarth; Hamid A Hadi; Reto Brun; Harald Meimberg; Günther Heubl
ent-Dioncophylleine A and related dehydrogenated naphthylisoquinoline alkaloids, the first Asian dioncophyllaceae-type alkaloids, from the "new"plant species Ancistrocladus benomensis.
Journal of natural products 2005;68(5):686-90.
2005: Deniz Tasdemir; Reto Brun; Remo Perozzo; Ali A Dönmez
Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of turkish medicinal plants.
Phytotherapy research : PTR 2005;19(2):162-6.
2005: Deniz Tasdemir; Nadide Deniz Güner; Remo Perozzo; Reto Brun; Ali A Dönmez; Ihsan Calis; Peter Rüedi
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.
Phytochemistry 2005;66(3):355-62.
2005: Axel G Griesbeck; Tamer T El-Idreesy; Lars-Oliver Höinck; Johann Lex; Reto Brun
Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities.
Bioorganic & medicinal chemistry letters 2005;15(3):595-7.
2004: Gerhard Bringmann; Michael Dreyer; Heiko Rischer; Kristina Wolf; Hamid A Hadi; Reto Brun; Harald Meimberg; Günther Heubl
Ancistrobenomine a, the first naphthylisoquinoline oxygenated at Me-3, and related 5,1'-coupled alkaloids, from the "new" plant species ancistrocladusbenomensis.
Journal of natural products 2004;67(12):2058-62.
2004: Gerhard Bringmann; Michael Dreyer; Manuela Michel; Francis S K Tayman; Reto Brun
Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus heyneanus Wall.
Phytochemistry 2004;65(21):2903-7.
2004: Hasan Kirmizibekmez; Ihsan Calis; Remo Perozzo; Reto Brun; Ali A Dönmez; Anthony Linden; Peter Rüedi; Deniz Tasdemir
Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis.
Planta medica 2004;70(8):711-7.
2004: Gerhard Bringmann; Michael Dreyer; Johan Faber; Petur W Dalsgaard; Dan Staerk; Jerzy W Jaroszewski; Henry Ndangalasi; Frank Mbago; Reto Brun; S Brøgger Christensen
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.
Journal of natural products 2004;67(5):743-8.
2003: Gerhard Bringmann; Michael Dreyer; Johan Faber; Petur W Dalsgaard; Dan Staerk; Jerzy W Jaroszewski; Henry Ndangalasi; Frank Mbago; Reto Brun; Matthias Reichert; Katja Maksimenka; S Brøgger Christensen
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
Journal of natural products 2003;66(9):1159-65.
2003: Gerhard Bringmann; Kim Messer; Babett Schwöbel; Reto Brun; Laurent Aké Assi
Habropetaline A, an antimalarial naphthylisoquinoline alkaloid from Triphyophyllum peltatum.
Phytochemistry 2003;62(3):345-9.
2003: Gerhard Bringmann; Wael Saeb; Markus Rückert; Jan Mies; Manuela Michel; Virima Mudogo; Reto Brun
Ancistrolikokine D, a 5,8'-coupled naphthylisoquinoline alkaloid, and related natural products from Ancistrocladus likoko.
Phytochemistry 2003;62(4):631-6.
2002: Axel G Griesbeck; Tamer T El-Idreesy; Maren Fiege; Reto Brun
Synthesis of antimalarial 1,2,4-trioxanes via photooxygenation of a chiral allylic alcohol.
Organic letters 2002;4(24):4193-5.
2002: Gerhard Bringmann; Michael Wohlfarth; Heiko Rischer; Jan Schlauer; Reto Brun
Extract screening by HPLC coupled to MS-MS, NMR, and CD: a dimeric and three monomeric naphthylisoquinoline alkaloids from Ancistrocladus griffithii.
Phytochemistry 2002;61(2):195-204.
2002: Gerhard Bringmann; Dirk Menche; Jürgen Kraus; Jörg Mühlbacher; Karl Peters; Eva-Maria Peters; Reto Brun; Merhatibeb Bezabih; Berhanu M Abegaz
Atropo-enantioselective total synthesis of knipholone and related antiplasmodial phenylanthraquinones.
The Journal of organic chemistry 2002;67(16):5595-610.
2002: Berhanu M Abegaz; Merhatibeb Bezabih; Thomas Msuta; Reto Brun; Dirk Menche; Jörg Mühlbacher; Gerhard Bringmann
Gaboroquinones A and B and 4'-O-demethylknipholone-4'-O-beta-D-glucopyranoside, phenylanthraquinones from the roots of Bulbine frutescens.
Journal of natural products 2002;65(8):1117-21.
2002: Gerhard Bringmann; Kim Messer; Reto Brun; Virima Mudogo
Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis.
Journal of natural products 2002;65(8):1096-101.
2002: Gerhard Bringmann; Kim Messer; Kristina Wolf; Jörg Mühlbacher; Matthias Grüne; Reto Brun; Adriaan M Louis
Dioncophylline E from Dioncophyllum thollonii, the first 7,3'-coupled dioncophyllaceous naphthylisoquinoline alkaloid.
Phytochemistry 2002;60(4):389-97.
2000: Gerhard Bringmann; A Hamm; C Günther; M Michel; Reto Brun; Virima Mudogo
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
Journal of natural products 2000;63(11):1465-70.
2000: Gerhard Bringmann; C Günther; Wael Saeb; Jan Mies; AR Wickramasinghe; Virima Mudogo; Reto Brun
Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko.
Journal of natural products 2000;63(10):1333-7.
2000: Gerhard Bringmann; C Günther; Wael Saeb; Jan Mies; Reto Brun; LA Assi
8-O-methyldioncophyllinol B and revised structures of other 7,6'-coupled naphthylisoquinoline alkaloids from Triphyophyllum peltatum (Dioncophyllaceae).
Phytochemistry 2000;54(3):337-46.
2000: Gerhard Bringmann; M Ochse; Gerhard Zotz; K Peters; EM Peters; Reto Brun; Jan Schlauer
6-Hydroxyluteolin-7-O-(1''-alpha-rhamnoside) from Vriesea sanguinolenta Cogn. and Marchal (Bromeliaceae).
Phytochemistry 2000;53(8):965-9.