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Nick Barker

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Publications

TOP 3
David W M Tan; Nick Barker
Stem cell reprogramming as a driver of basal cell carcinoma.
Nick Barker; Alexander van Oudenaarden; Hans Clevers
Identifying the stem cell of the intestinal crypt: strategies and pitfalls.
Johan H van Es; Alexander van Oudenaarden; Laura Zeinstra; Annie Ng Yee Nee; Nick Barker; Alex Gregorieff; Jeroen Korving; Anna Lyubimova; Anton C M Martens; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Maaike van den Born; Hans Clevers
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.

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All Publications

2012: David W M Tan; Nick Barker
Stem cell reprogramming as a driver of basal cell carcinoma.
Nature cell biology 2012;14(12):1246-7.
2012: Nick Barker; Alexander van Oudenaarden; Hans Clevers
Identifying the stem cell of the intestinal crypt: strategies and pitfalls.
Cell stem cell 2012;11(4):452-60.
2012: Johan H van Es; Alexander van Oudenaarden; Laura Zeinstra; Annie Ng Yee Nee; Nick Barker; Alex Gregorieff; Jeroen Korving; Anna Lyubimova; Anton C M Martens; Nobuo Sasaki; Toshiro Sato; Marc van de Wetering; Maaike van den Born; Hans Clevers
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage.
Nature cell biology 2012;14(10):1099-104.
2012: Nick Barker; Meritxell Huch; Pekka Kujala; Marc Leushacke; Annie Ng; Peter J Peters; Richard Poulsom; Maarten B Rookmaaker; Hugo Snippert; Shawna Tan; Marc van de Wetering; Johan H van Es; Marianne C Verhaar; Hans Clevers
Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.
Cell reports 2012;2(3):540-52.
2012: Wim de Lau; Rodney P DeKoter; Frans Hofhuis; Pekka Kujala; Vivian S W Li; Anton Martens; Sabine Middendorp; Edward Nieuwenhuis; Peter J Peters; Kerstin Schneeberger; Nick Barker; Hans Clevers
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".
Molecular and cellular biology 2012;32(18):3639-47.
2011: Wim de Lau; Daniele Guardavaccaro; Andrea Haegebarth; Albert J R Heck; Bon-Kyoung Koo; Pekka Kujala; Vivian S W Li; Teck Y Low; shabaz mohammed; Yasuaki Mohri; Katsuhiko Nishimori; Peter J Peters; Richard B M Schasfoort; Daniel E Stange; Hans Teunissen; Marc van de Wetering; Johan E van Es; Nick Barker; Hans Clevers
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
Nature 2011;476(7360):293-7.
2011: Maria Kasper; Viljar Jaks; Alexandra Are; Åsa Bergström; Anja Schwäger; Nick Barker; Jessica Svärd; Stephan Teglund; Rune Toftgård
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(10):4099-104.
2011: Toshiro Sato; Johan H van Es; Hugo J Snippert; Daniel E Stange; Robert G Vries; Maaike van den Born; Nick Barker; Noah F Shroyer; Marc van de Wetering; Hans Clevers
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature 2011;469(7330):415-8.
2010: Nick Barker; Sina Bartfeld; Hans Clevers
Tissue-resident adult stem cell populations of rapidly self-renewing organs.
Cell stem cell 2010;7(6):656-70.
2010: Hugo J Snippert; Laurens G van der Flier; Toshiro Sato; Johan H van Es; Maaike van den Born; Carla Kroon-Veenboer; Nick Barker; Allon M Klein; Jacco van Rheenen; Benjamin D Simons; Hans Clevers
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.
Cell 2010;143(1):134-44.
2010: Nick Barker; Hans Clevers
Lineage tracing in the intestinal epithelium.
Current protocols in stem cell biology 2010;Chapter 5():Unit5A.4.
2010: Hugo J Snippert; Andrea Haegebarth; Maria Kasper; Viljar Jaks; Johan H van Es; Nick Barker; Marc van de Wetering; Maaike van den Born; Harry Begthel; Robert G Vries; Daniel E Stange; Rune Toftgård; Hans Clevers
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Science (New York, N.Y.) 2010;327(5971):1385-9.
2010: Nick Barker; Meritxell Huch; Pekka Kujala; Marc van de Wetering; Hugo J Snippert; Johan H van Es; Toshiro Sato; Daniel E Stange; Harry Begthel; Maaike van den Born; Esther Danenberg; Stieneke van den Brink; Jeroen Korving; Arie Abo; Peter J Peters; Nick Wright; Richard Poulsom; Hans Clevers
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
Cell stem cell 2010;6(1):25-36.
2009: Hugo J Snippert; Johan H van Es; Maaike van den Born; Harry Begthel; Daniel E Stange; Nick Barker; Hans Clevers
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.
Gastroenterology 2009;136(7):2187-2194.e1.
2009: Toshiro Sato; Robert G Vries; Hugo J Snippert; Marc van de Wetering; Nick Barker; Daniel E Stange; Johan H van Es; Arie Abo; Pekka Kujala; Peter J Peters; Hans Clevers
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Nature 2009;459(7244):262-5.
2009: Laurens G van der Flier; Marielle E van Gijn; Pantelis Hatzis; Pekka Kujala; Andrea Haegebarth; Daniel E Stange; Harry Begthel; Maaike van den Born; Victor Guryev; Irma Oving; Johan H van Es; Nick Barker; Peter J Peters; Marc van de Wetering; Hans Clevers
Transcription factor achaete scute-like 2 controls intestinal stem cell fate.
Cell 2009;136(5):903-12.
2009: Nick Barker; Rachel A Ridgway; Johan H van Es; Marc van de Wetering; Harry Begthel; Maaike van den Born; Esther Danenberg; Alan R Clarke; Owen J Sansom; Hans Clevers
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature 2009;457(7229):608-11.
2008: Nick Barker; Marc van de Wetering; Hans Clevers
The intestinal stem cell.
Genes & development 2008;22(14):1856-64.
2008: Nick Barker; Johan H van Es; V Jaks; M Kasper; H Snippert; R Toftgård; Hans Clevers
Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.
Cold Spring Harbor symposia on quantitative biology 2008;73():351-6.
2007: Nick Barker; Hans Clevers
Tracking down the stem cells of the intestine: strategies to identify adult stem cells.
Gastroenterology 2007;133(6):1755-60.
2007: Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Nature 2007;449(7165):1003-7.
2007: Wim de Lau; Nick Barker; Hans Clevers
WNT signaling in the normal intestine and colorectal cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():471-91.
2006: Nick Barker; Hans Clevers
Mining the Wnt pathway for cancer therapeutics.
Nature reviews. Drug discovery 2006;5(12):997-1014.
2006: Ewa Markiewicz; Katarzyna Tilgner; Nick Barker; Mark van de Wetering; Hans Clevers; Malgorzata Dorobek; Irena Hausmanowa-Petrusewicz; Frans C S Ramaekers; Jos L V Broers; W Matthijs Blankesteijn; Georgia Salpingidou; Robert G Wilson; Juliet A Ellis; Christopher J Hutchison
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
The EMBO journal 2006;25(14):3275-85.
2005: Marieke A G Essers; Lydia M M de Vries-Smits; Nick Barker; Paulien E Polderman; Boudewijn M T Burgering; Hendrik C Korswagen
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
Science (New York, N.Y.) 2005;308(5725):1181-4.
2003: Johan H van Es; Nick Barker; Hans Clevers
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway.
Current opinion in genetics & development 2003;13(1):28-33.
2002: Adam F L Hurlstone; Ivan A Olave; Nick Barker; Mascha van Noort; Hans Clevers
Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein.
The Biochemical journal 2002;364(Pt 1):255-64.
2002: N Yamakawa-Karakida; Kanji Sugita; Takeshi Inukai; Kumiko Goi; M Nakamura; Kanako Uno; H Sato; Keiko Kagami; Nick Barker; Shinpei Nakazawa
Ligand activation of peroxisome proliferator-activated receptor gamma induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity.
Cell death and differentiation 2002;9(5):513-26.
2002: Helen Brantjes; Nick Barker; Johan H van Es; Hans Clevers
TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling.
Biological chemistry 2002;383(2):255-61.
2001: Nick Barker; H Clevers
Tumor environment: a potent driving force in colorectal cancer?
Trends in molecular medicine 2001;7(12):535-7.
2001: Nick Barker; Adam F L Hurlstone; Hannah Musisi; A Miles; Mariann Bienz; Hans Clevers
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation.
The EMBO journal 2001;20(17):4935-43.
2001: Marc van de Wetering; Nick Barker; IC Harkes; Michiel van der Heyden; N J Dijk; Antoinette Hollestelle; Jan G M Klijn; Hans Clevers; Mieke Schutte
Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.
Cancer research 2001;61(1):278-84.
2000: Nick Barker; Hans Clevers
Catenins, Wnt signaling and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(11):961-5.
2000: Nick Barker; Patrice J Morin; Hans Clevers
The Yin-Yang of TCF/beta-catenin signaling.
Advances in cancer research 2000;77():1-24.
1999: Tohru Ishitani; Jun Ninomiya-Tsuji; S Nagai; M Nishita; MD Meneghini; Nick Barker; M Waterman; Bruce Bowerman; H Clevers; Hiroshi Shibuya; Kunihiro Matsumoto
The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.
Nature 1999;399(6738):798-802.
1999: Nick Barker; Gerwin Huls; V Korinek; Hans Clevers
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium.
The American journal of pathology 1999;154(1):29-35.
1998: V Korinek; Nick Barker; Petra Moerer; Elly van Donselaar; Gerwin Huls; Peter J Peters; Hans Clevers
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
Nature genetics 1998;19(4):379-83.
1998: V Korinek; Nick Barker; K Willert; M Molenaar; J Roose; G Wagenaar; M Markman; W Lamers; O Destree; Hans Clevers
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.
Molecular and cellular biology 1998;18(3):1248-56.
1997: Patrice J Morin; Andrew B Sparks; V Korinek; Nick Barker; Hans Clevers; Bert Vogelstein; Kenneth W Kinzler
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Science (New York, N.Y.) 1997;275(5307):1787-90.
1997: V Korinek; Nick Barker; Patrice J Morin; D van Wichen; Roel A de Weger; Kenneth W Kinzler; Bert Vogelstein; Hans Clevers
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Science (New York, N.Y.) 1997;275(5307):1784-7.
1997: Nick Barker; J R Young; W Ivan Morrison; Shirley A Ellis
Sequence diversity present within the 5' upstream regions of BoLA class I genes.
Immunogenetics 1997;46(4):352-4.