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Larisa Poluektova

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Jinjin Zhang; Jill Wagoner; Tatiana K Bronich; Jong Oh Kim; Jaclyn Knibbe; Edward Makarov; Andrea Mulvenon; Natalia Osna; Larisa Poluektova
Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection.
Upal Roy; Nathan Smith; Susan Swindells; Yazen Alnouti; Shantanu Balkundi; Samuel M Cohen; Prasanta Dash; Nagsen Gautum; Santhi Gorantla; Georgette Kanmogne; Andrea Martinez-Skinner; JoEllyn McMillan; Jane Meza; R Lee Mosley; Larisa Poluektova; Howard E Gendelman
Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.
Prasanta K Dash; Harris A Gelbard; Howard E Gendelman; Santhi Gorantla; Joellyn McMillan; Rodney L Mosley; Yazen Alnouti; Shantanu Balkundi; Upal Roy; Larisa Poluektova
Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice.

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All Publications

2013: Jinjin Zhang; Jill Wagoner; Tatiana K Bronich; Jong Oh Kim; Jaclyn Knibbe; Edward Makarov; Andrea Mulvenon; Natalia Osna; Larisa Poluektova
Antiviral peptide nanocomplexes as a potential therapeutic modality for HIV/HCV co-infection.
Biomaterials 2013;34(15):3846-57.
2012: Upal Roy; Nathan Smith; Susan Swindells; Yazen Alnouti; Shantanu Balkundi; Samuel M Cohen; Prasanta Dash; Nagsen Gautum; Santhi Gorantla; Georgette Kanmogne; Andrea Martinez-Skinner; JoEllyn McMillan; Jane Meza; R Lee Mosley; Larisa Poluektova; Howard E Gendelman
Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.
The Journal of infectious diseases 2012;206(10):1577-88.
2012: Prasanta K Dash; Harris A Gelbard; Howard E Gendelman; Santhi Gorantla; Joellyn McMillan; Rodney L Mosley; Yazen Alnouti; Shantanu Balkundi; Upal Roy; Larisa Poluektova
Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice.
AIDS (London, England) 2012;26(17):2135-44.
2012: Santhi Gorantla; Howard E Gendelman; Larisa Poluektova
Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012;7(2):352-62.
2012: Santhi Gorantla; Larisa Poluektova; Howard E Gendelman
Rodent models for HIV-associated neurocognitive disorders.
Trends in neurosciences 2012;35(3):197-208.
2012: Govardhana Rao Yannam; Tanuja Gutti; Larisa Poluektova
IL-23 in infections, inflammation, autoimmunity and cancer: possible role in HIV-1 and AIDS.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012;7(1):95-112.
2012: Hardeep S Oberoi; Larisa Poluektova; Masanao Yokohira; Yazen Alnouti; Lora L Arnold; Samuel M Cohen; Jiangeng Huang; Alexander V Kabanov; Frederic C Laquer; Natalia V Nukolova; Tatiana K Bronich
Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice.
International journal of nanomedicine 2012;7():2557-71.
2012: Georgette D Kanmogne; Xinming Liu; Joellyn McMillan; Larisa Poluektova; Upal Roy; Sangya Singh; Nathan Smith; You Zhou; Yazen Alnouti; Shantanu Balkundi; Tatiana Bronich; Nagsen Gautam; Santhi Gorantla; Alexander Kabanov; Howard E Gendelman
Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells.
International journal of nanomedicine 2012;7():2373-88.
2010: Santhi Gorantla; Edward Makarov; Jennifer Finke-Dwyer; Antonio Castanedo; Adelina Holguin; Catherine L Gebhart; Howard E Gendelman; Larisa Poluektova
Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.
The American journal of pathology 2010;177(6):2938-49.
2010: Santhi Gorantla; Edward Makarov; Deepa Roy; Jennifer Finke-Dwyer; Leonard Murrin; Howard E Gendelman; Larisa Poluektova
Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2010;5(3):456-68.
2010: Santhi Gorantla; Edward Makarov; Jennifer Finke-Dwyer; Catherine L Gebhart; William Domm; Stephen Dewhurst; Howard E Gendelman; Larisa Poluektova
CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):7082-91.
2010: Dawn Eggert; Prasanta K Dash; Santhi Gorantla; Huanyu Dou; Giovanni Schifitto; Sanjay B Maggirwar; Stephen Dewhurst; Larisa Poluektova; Harris A Gelbard; Howard E Gendelman
Neuroprotective activities of CEP-1347 in models of neuroAIDS.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):746-56.
2010: Serguei V Vinogradov; Larisa Poluektova; Edward Makarov; Trevor Gerson; Madapathage T Senanayake
Nano-NRTIs: efficient inhibitors of HIV type-1 in macrophages with a reduced mitochondrial toxicity.
Antiviral chemistry & chemotherapy 2010;21(1):1-14.
2009: Dawn Eggert; Prasanta K Dash; Nawal Serradji; Chang-Zhi Dong; Pascal Clayette; Francoise Heymans; Huanyu Dou; Santhi Gorantla; Harris A Gelbard; Larisa Poluektova; Howard E Gendelman
Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders.
Journal of neuroimmunology 2009;213(1-2):47-59.
2008: Santhi Gorantla; Jianuo Liu; Tong Wang; Adelina Holguin; Hannah Sneller; Huanyu Dou; Jonathan Kipnis; Larisa Poluektova; Howard E Gendelman
Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis.
Glia 2008;56(2):223-32.
2007: Santhi Gorantla; Jianou Liu; Hannah Sneller; Huanyu Dou; Adelina Holguin; Lynette Smith; Tsuneya Ikezu; David J Volsky; Larisa Poluektova; Howard E Gendelman
Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4345-56.
2007: Santhi Gorantla; Hannah Sneller; Lisa Walters; J Graham Sharp; Samuel J Pirruccello; John T West; Charles Wood; Stephen Dewhurst; Howard E Gendelman; Larisa Poluektova
Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.
Journal of virology 2007;81(6):2700-12.
2006: Santhi Gorantla; Huanyu Dou; Michael D Boska; Christopher J Destache; Jay Nelson; Larisa Poluektova; Barrett Rabinow; Howard E Gendelman; R Lee Mosley
Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery.
Journal of leukocyte biology 2006;80(5):1165-74.
2006: Huanyu Dou; Christopher J Destache; Justin Morehead; R Lee Mosley; Michael D Boska; Jeffrey D Kingsley; Santhi Gorantla; Larisa Poluektova; Jay A Nelson; Mahesh Chaubal; Jane Werling; James Kipp; Barrett Rabinow; Howard E Gendelman
Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery.
Blood 2006;108(8):2827-35.
2006: Yuri Persidsky; Larisa Poluektova
Immune privilege and HIV-1 persistence in the CNS.
Immunological reviews 2006;213():180-94.
2006: Bin Li; Ellen G Duysen; Larisa Poluektova; Leonard Murrin; Oksana Lockridge
Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase.
Toxicology and applied pharmacology 2006;214(2):152-65.
2005: Larisa Poluektova; Vakara Meyer; Lisa Walters; Ximena Paez; Howard E Gendelman
Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis.
Glia 2005;52(4):344-53.
2005: Raghava Potula; Larisa Poluektova; Bryan Knipe; Jesse Chrastil; David Heilman; Huanyu Dou; Osamu Takikawa; David H Munn; Howard E Gendelman; Yuri Persidsky
Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.
Blood 2005;106(7):2382-90.
2005: Huanyu Dou; Brent Ellison; Jennifer Bradley; Alexander Kasiyanov; Larisa Poluektova; Huangui Xiong; Sanjay B Maggirwar; Stephen Dewhurst; Harris A Gelbard; Howard E Gendelman
Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(37):8375-85.
2005: Santhi Gorantla; Kathlyn Santos; Vakara Meyer; Stephen Dewhurst; William J Bowers; Howard Federoff; Howard E Gendelman; Larisa Poluektova
Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.
Journal of virology 2005;79(4):2124-32.
2004: Larisa Poluektova; Santhi Gorantla; Jill Faraci; Kevin Birusingh; Huanyu Dou; Howard E Gendelman
Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7610-7.
2004: Kimberly A Carlson; Jenae Limoges; Garrett D Pohlman; Larisa Poluektova; Dianne Langford; Eliezer Masliah; Tsuneya Ikezu; Howard E Gendelman
OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis.
Journal of neuroimmunology 2004;150(1-2):186-98.
2004: Michael D Boska; R Lee Mosley; Mehmood Nawab; Jay A Nelson; Marina Zelivyanskaya; Larisa Poluektova; Mariano Uberti; Huanyu Dou; Travis B Lewis; Howard E Gendelman
Advances in neuroimaging for HIV-1 associated neurological dysfunction: clues to the diagnosis, pathogenesis and therapeutic monitoring.
Current HIV research 2004;2(1):61-78.
2004: Adeline Nukuna; Howard E Gendelman; Jenae Limoges; Jennifer Rasmussen; Larisa Poluektova; Anuja Ghorpade; Yuri Persidsky
Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis.
Journal of neurovirology 2004;10 Suppl 1():82-90.
2003: Huanyu Dou; Kevin Birusingh; Jill Faraci; Santhi Gorantla; Larisa Poluektova; Sanjay B Maggirwar; Stephen Dewhurst; Harris A Gelbard; Howard E Gendelman
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(27):9162-70.
2003: Marina Zelivyanskaya; Jay A Nelson; Larisa Poluektova; Mariano Uberti; Melissa Mellon; Howard E Gendelman; Michael D Boska
Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging.
Journal of neuroscience research 2003;73(3):284-95.
2002: Larisa Poluektova; David H Munn; Yuri Persidsky; Howard E Gendelman
Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3941-9.
2001: Larisa Poluektova; T Moran; Marina Zelivyanskaya; Susan Swindells; Howard E Gendelman; Yuri Persidsky
The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: relevance for HIV-1-associated dementia.
Journal of neuroimmunology 2001;120(1-2):112-28.
2001: Jenae Limoges; Larisa Poluektova; W Ratanasuwan; Jennifer Rasmussen; Marina Zelivyanskaya; Daniel R McClernon; E Randall Lanier; Howard E Gendelman; Yuri Persidsky
The efficacy of potent anti-retroviral drug combinations tested in a murine model of HIV-1 encephalitis.
Virology 2001;281(1):21-34.
2000: Jenae Limoges; Yuri Persidsky; Larisa Poluektova; Jennifer Rasmussen; W Ratanasuwan; Marina Zelivyanskaya; Daniel R McClernon; E Randall Lanier; Howard E Gendelman
Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice.
Neurology 2000;54(2):379-89.
1999: Walter E Zink; Jialin Charles Zheng; Yuri Persidsky; Larisa Poluektova; Howard E Gendelman
The neuropathogenesis of HIV-1 infection.
FEMS immunology and medical microbiology 1999;26(3-4):233-41.
1999: Larisa Poluektova; M Madre; R Zhuk; NA Osna; L Somashenkova; A Zvirbliene; A Socnev; Manzoor M Khan
Immunoregulatory effects of N9-benzyl- and N7-benzyl-8-bromoguanines.
International journal of immunopharmacology 1999;21(11):777-92.
1999: Larisa Poluektova; G K Huggler; E B Patterson; Manzoor M Khan
Involvement of protein kinase A in histamine-mediated inhibition of IL-2 mRNA expression in mouse splenocytes.
Immunopharmacology 1999;41(2):77-87.
1998: Larisa Poluektova; Manzoor M Khan
Protein kinase A inhibitors reverse histamine-mediated regulation of IL-5 secretion.
Immunopharmacology 1998;39(1):9-19.
1996: Larisa Poluektova; K Krzystyniak; R Desjardins; D Flipo; Michel Fournier
In vitro lymphotoxicity and selective T cell immunotoxicity of high doses of acyclovir and its derivatives in mice.
International journal of immunopharmacology 1996;18(6-7):429-38.
1995: Larisa Poluektova; Y Maurinsh; M Lidaks; N Gromova
Immunostimulating properties of the complexes of inosine derivatives.
International journal of immunopharmacology 1995;17(11):941-7.
1989: A Y Rubins; H M Wekhsler; A G Merson; L N Guseva; H Y Grant; Larisa Poluektova; N M Gipsh; G Y Rubine
Immunopathogenesis and immunocorrection of psoriasis.
Acta dermato-venereologica. Supplementum 1989;146():13-5.
1985: A Ia Rubinsk; A L Mashkilleĭson; Kh M Veksler; Zh P Graudinia; Larisa Poluektova
[Natural killer activity of peripheral blood in psoriasis patients].
Vestnik dermatologii i venerologii 1985;(12):8-10.