Yusuf Hannun

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Yu Hong; Zeidan Youssef H; Wu Bill X; Jenkins Russell W; Flotte Terence R; Hannun Yusuf A; Virella-Lowell Isabel
Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.
Idkowiak-Baldys Jolanta; Baldys Aleksander; Raymond John R; Hannun Yusuf A
Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner.
Wu Bill X; Zeidan Youssef H; Hannun Yusuf A
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.

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All Publications

2009: Yu Hong; Zeidan Youssef H; Wu Bill X; Jenkins Russell W; Flotte Terence R; Hannun Yusuf A; Virella-Lowell Isabel
Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis.
American journal of respiratory cell and molecular biology 2009;41(3):367-75.
2009: Idkowiak-Baldys Jolanta; Baldys Aleksander; Raymond John R; Hannun Yusuf A
Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner.
The Journal of biological chemistry 2009;284(33):22322-31.
2009: Wu Bill X; Zeidan Youssef H; Hannun Yusuf A
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation.
Biochimica et biophysica acta 2009;1791(8):730-9.
2009: Gustafsson Kristin; Sander Birgitta; Bielawski Jacek; Hannun Yusuf A; Flygare Jenny
Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.
Molecular cancer research : MCR 2009;7(7):1086-98.
2009: Yang Guang; Badeanlou Leylla; Bielawski Jacek; Roberts Amanda J; Hannun Yusuf A; Samad Fahumiya
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E211-24.
2009: Jenkins Russell W; Canals Daniel; Hannun Yusuf A
Roles and regulation of secretory and lysosomal acid sphingomyelinase.
Cellular signalling 2009;21(6):836-46.
2009: Kitatani Kazuyuki; Sheldon Kely; Rajagopalan Vinodh; Anelli Viviana; Jenkins Russell W; Sun Ying; Grabowski Gregory A; Obeid Lina M; Hannun Yusuf A
Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
The Journal of biological chemistry 2009;284(19):12972-8.
2009: Kitatani Kazuyuki; Sheldon Kely; Anelli Viviana; Jenkins Russell W; Sun Ying; Grabowski Gregory A; Obeid Lina M; Hannun Yusuf A
Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
The Journal of biological chemistry 2009;284(19):12979-88.
2009: Kitagaki Hiroshi; Cowart L Ashley; Matmati Nabil; Montefusco David; Gandy Jason; de Avalos Silvia Vaena; Novgorodov Sergei A; Zheng Jim; Obeid Lina M; Hannun Yusuf A
ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae.
The Journal of biological chemistry 2009;284(16):10818-30.
2009: Villa Nancy Y; Kupchak Brian R; Garitaonandia Ibon; Smith Jessica L; Alonso Emilio; Alford Charlene; Cowart L Ashley; Hannun Yusuf A; Lyons Thomas J
Sphingolipids function as downstream effectors of a fungal PAQR.
Molecular pharmacology 2009;75(4):866-75.
2009: Bartke Nana; Hannun Yusuf A
Bioactive sphingolipids: metabolism and function.
Journal of lipid research 2009;50 Suppl():S91-6.
2009: Hannun Yusuf A
We need to tackle the mismatch between supply and demand.
Nature 2009;458(7237):404.
2009: Bai Aiping; Szulc Zdzislaw M; Bielawski Jacek; Mayroo Nalini; Liu Xiang; Norris James; Hannun Yusuf A; Bielawska Alicja
Synthesis and bioevaluation of omega-N-amino analogs of B13.
Bioorganic & medicinal chemistry 2009;17(5):1840-8.
2009: Matmati Nabil; Kitagaki Hiroshi; Montefusco David; Mohanty Bidyut K; Hannun Yusuf A
Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.
The Journal of biological chemistry 2009;284(13):8241-6.
2009: Mahdy Ayman E M; Cheng Joseph C; Li Jun; Elojeimy Saeed; Meacham William D; Turner Lorianne S; Bai Aiping; Gault Christopher R; McPherson Alex S; Garcia Nicole; Beckham Thomas H; Saad Antonio; Bielawska Alicja; Bielawski Jacek; Hannun Yusuf A; Keane Thomas E; Taha Mohhammed I; Hammouda Hisham M; Norris James S; Liu Xiang
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(3):430-8.
2009: Mukhopadhyay Archana; Saddoughi Sahar A; Song Pengfei; Sultan Iyad; Ponnusamy Suriyan; Senkal Can E; Snook Christopher F; Arnold Hugh K; Sears Rosalie C; Hannun Yusuf A; Ogretmen Besim
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(3):751-63.
2009: Kawamori Toshihiko; Kaneshiro Tatsuya; Okumura Masae; Maalouf Samer; Uflacker Andre; Bielawski Jacek; Hannun Yusuf A; Obeid Lina M
Role for sphingosine kinase 1 in colon carcinogenesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(2):405-14.
2009: Snider Ashley J; Kawamori Toshihiko; Bradshaw Sarah G; Orr K Alexa; Gilkeson Gary S; Hannun Yusuf A; Obeid Lina M
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(1):143-52.
2009: Nahas Ziad; Jiang Yan; Zeidan Youssef H; Bielawska Alicja; Szulc Zdzislaw; Devane Lindsay; Kalivas Peter; Hannun Yusuf A
Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.
Behavioural brain research 2009;197(1):41-4.
2008: Montes L-Ruth; López David J; Sot Jesús; Bagatolli Luis A; Stonehouse Martin J; Vasil Michael L; Wu Bill X; Hannun Yusuf A; Goñi Félix M; Alonso Alicia
Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis.
Biochemistry 2008;47(43):11222-30.
2008: Chudakova Daria A; Zeidan Youssef H; Wheeler Brian W; Yu Jin; Novgorodov Sergei A; Kindy Mark S; Hannun Yusuf A; Gudz Tatyana I
Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity.
The Journal of biological chemistry 2008;283(43):28806-16.
2008: Clarke Christopher J; Guthrie J Michael; Hannun Yusuf A
Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
Molecular pharmacology 2008;74(4):1022-32.
2008: Jin Junfei; Hou Qi; Mullen Thomas D; Zeidan Youssef H; Bielawski Jacek; Kraveka Jacqueline M; Bielawska Alicja; Obeid Lina M; Hannun Yusuf A; Hsu Yi-Te
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.
The Journal of biological chemistry 2008;283(39):26509-17.
2008: Pata Mickael O; Wu Bill X; Bielawski Jacek; Xiong Tou Cheu; Hannun Yusuf A; Ng Carl K-Y
Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice.
The Plant journal : for cell and molecular biology 2008;55(6):1000-9.
2008: Zeidan Youssef H; Jenkins Russell W; Korman John B; Liu Xiang; Obeid Lina M; Norris James S; Hannun Yusuf A
Molecular targeting of acid ceramidase: implications to cancer therapy.
Current drug targets 2008;9(8):653-61.
2008: Panjarian Shoghag; Kozhaya Lina; Arayssi Sawsan; Yehia Maisaa; Bielawski Jacek; Bielawska Alicja; Usta Julnar; Hannun Yusuf A; Obeid Lina M; Dbaibo Ghassan S
De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.
Prostaglandins & other lipid mediators 2008;86(1-4):41-8.
2008: Kitatani Kazuyuki; Idkowiak-Baldys Jolanta; Hannun Yusuf A
The sphingolipid salvage pathway in ceramide metabolism and signaling.
Cellular signalling 2008;20(6):1010-8.
2008: Shah Charmi; Yang Guang; Lee Ian; Bielawski Jacek; Hannun Yusuf A; Samad Fahumiya
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.
The Journal of biological chemistry 2008;283(20):13538-48.
2008: Misra Suniti; Obeid Lina M; Hannun Yusuf A; Minamisawa Susumu; Berger Franklin G; Markwald Roger R; Toole Bryan P; Ghatak Shibnath
Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
The Journal of biological chemistry 2008;283(21):14335-44.
2008: Matmati Nabil; Hannun Yusuf A
Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases.
Journal of lipid research 2008;49(5):922-8.
2008: Zeidan Youssef H; Jenkins Russell W; Hannun Yusuf A
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.
The Journal of cell biology 2008;181(2):335-50.
2008: Hannun Yusuf A
NIH: grants revamp needs grounding in evidence.
Nature 2008;452(7189):811.
2008: Hannun Yusuf A; Obeid Lina M
Principles of bioactive lipid signalling: lessons from sphingolipids.
Nature reviews. Molecular cell biology 2008;9(2):139-50.
2008: Holman David H; Turner Lorianne S; El-Zawahry Ahmed; Elojeimy Saeed; Liu Xiang; Bielawski Jacek; Szulc Zdzislaw M; Norris Kristi; Zeidan Youssef H; Hannun Yusuf A; Bielawska Alicja; Norris James S
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.
Cancer chemotherapy and pharmacology 2008;61(2):231-42.
2008: Dahm F; Bielawska A; Nocito A; Georgiev P; Szulc Z M; Bielawski J; Jochum W; Dindo D; Hannun Y A; Clavien P-A
Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.
British journal of cancer 2008;98(1):98-105.
2008: Bielawska Alicja; Bielawski Jacek; Szulc Zdzislaw M; Mayroo Nalini; Liu Xiang; Bai AiPing; Elojeimy Saeed; Rembiesa Barbara; Pierce Jason; Norris James S; Hannun Yusuf A
Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.
Bioorganic & medicinal chemistry 2008;16(2):1032-45.
2008: Szulc Zdzislaw M; Mayroo Nalini; Bai AiPing; Bielawski Jacek; Liu Xiang; Norris James S; Hannun Yusuf A; Bielawska Alicja
Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.
Bioorganic & medicinal chemistry 2008;16(2):1015-31.
2008: Zeidan Youssef H; Wu Bill X; Jenkins Russell W; Obeid Lina M; Hannun Yusuf A
A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):183-93.
2008: Liu Xiang; Elojeimy Saeed; Turner Lorianne S; Mahdy Ayman E M; Zeidan Youssef H; Bielawska Alicja; Bielawski Jacek; Dong Jian-Yun; El-Zawahry Ahmed M; Guo Gui-wen; Hannun Yusuf A; Holman David H; Rubinchik Semyon; Szulc Zdzislaw; Keane Thomas E; Tavassoli Mahvash; Norris James S
Acid ceramidase inhibition: a novel target for cancer therapy.
Frontiers in bioscience : a journal and virtual library 2008;13():2293-8.
2007: Shi Lihua; Bielawski Jacek; Mu Jinye; Dong Haili; Teng Chong; Zhang Jian; Yang Xiaohui; Tomishige Nario; Hanada Kentaro; Hannun Yusuf A; Zuo Jianru
Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis.
Cell research 2007;17(12):1030-40.
2007: Marchesini Norma; Jones Jeffrey A; Hannun Yusuf A
Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma.
Biochimica et biophysica acta 2007;1771(12):1418-28.
2007: Kitagaki Hiroshi; Cowart L Ashley; Matmati Nabil; Vaena de Avalos Silvia; Novgorodov Sergei A; Zeidan Youssef H; Bielawski Jacek; Obeid Lina M; Hannun Yusuf A
Isc1 regulates sphingolipid metabolism in yeast mitochondria.
Biochimica et biophysica acta 2007;1768(11):2849-61.
2007: Karahatay Serdar; Thomas Kesha; Koybasi Serap; Senkal Can E; Elojeimy Saeed; Liu Xiang; Bielawski Jacek; Day Terry A; Gillespie M Boyd; Sinha Debajyoti; Norris James S; Hannun Yusuf A; Ogretmen Besim
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.
Cancer letters 2007;256(1):101-11.
2007: Saad Antonio F; Meacham William D; Bai Aiping; Anelli Viviane; Elojeimy Saeed; Mahdy Ayman E M; Turner Lorianne S; Cheng Joe; Bielawska Alicja; Bielawski Jacek; Keane Thomas E; Obeid Lina M; Hannun Yusuf A; Norris James S; Liu Xiang
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.
Cancer biology & therapy 2007;6(9):1455-60.
2007: D'Angelo Giovanni; Polishchuk Elena; Di Tullio Giuseppe; Santoro Michele; Di Campli Antonella; Godi Anna; West Gun; Bielawski Jacek; Chuang Chia-Chen; van der Spoel Aarnoud C; Platt Frances M; Hannun Yusuf A; Polishchuk Roman; Mattjus Peter; De Matteis Maria Antonietta
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
Nature 2007;449(7158):62-7.
2007: Zeidan Youssef H; Hannun Yusuf A
Translational aspects of sphingolipid metabolism.
Trends in molecular medicine 2007;13(8):327-36.
2007: Coatrieux Christelle; Sanson Marie; Negre-Salvayre Anne; Parini Angelo; Hannun Yusuf; Itohara Shigeyoshi; Salvayre Robert; Auge Nathalie
MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway.
Free radical biology & medicine 2007;43(1):80-9.
2007: Kitatani Kazuyuki; Idkowiak-Baldys Jolanta; Hannun Yusuf A
Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.
The Journal of biological chemistry 2007;282(28):20647-56.
2007: Elojeimy Saeed; Liu Xiang; McKillop John C; El-Zawahry Ahmed M; Holman David H; Cheng Jonathan Y; Meacham William D; Mahdy Ayman Em; Saad Antonio F; Turner Lorianne S; Cheng Joseph; A Day Terrence; Dong Jian-Yun; Bielawska Alicja; Hannun Yusuf A; Norris James Scott
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(7):1259-63.
2007: Kraveka Jacqueline M; Li Li; Szulc Zdzislaw M; Bielawski Jacek; Ogretmen Besim; Hannun Yusuf A; Obeid Lina M; Bielawska Alicja
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.
The Journal of biological chemistry 2007;282(23):16718-28.
2007: Tani Motohiro; Hannun Yusuf A
Analysis of membrane topology of neutral sphingomyelinase 2.
FEBS letters 2007;581(7):1323-8.
2007: Cowart L Ashley; Hannun Yusuf A
Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.
The Journal of biological chemistry 2007;282(16):12330-40.
2007: Zeidan Youssef H; Hannun Yusuf A
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.
The Journal of biological chemistry 2007;282(15):11549-61.
2007: Tellier Edwige; Nègre-Salvayre Anne; Bocquet Beatrice; Itohara Shigeyoshi; Hannun Yusuf A; Salvayre Robert; Augé Nathalie
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Molecular and cellular biology 2007;27(8):2997-3007.
2007: Tani Motohiro; Hannun Yusuf A
Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization.
The Journal of biological chemistry 2007;282(13):10047-56.
2007: Martín Sergio F; Sawai Hirofumi; Villalba José M; Hannun Yusuf A
Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism.
Archives of biochemistry and biophysics 2007;459(2):295-300.
2007: Wu Bill X; Snook Christopher F; Tani Motohiro; Büllesbach Erika E; Hannun Yusuf A
Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium.
Journal of lipid research 2007;48(3):600-8.
2007: Senkal Can E; Ponnusamy Suriyan; Rossi Michael J; Bialewski Jacek; Sinha Debijyati; Jiang James C; Jazwinski S Michal; Hannun Yusuf A; Ogretmen Besim
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
Molecular cancer therapeutics 2007;6(2):712-22.
2007: Alvi F; Idkowiak-Baldys J; Baldys A; Raymond J R; Hannun Y A
Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes.
Cellular and molecular life sciences : CMLS 2007;64(3):263-70.
2007: Clarke Christopher J; Truong Thach-Giao; Hannun Yusuf A
Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.
The Journal of biological chemistry 2007;282(2):1384-96.
2007: Alvarez-Vasquez Fernando; Sims Kellie J; Voit Eberhard O; Hannun Yusuf A
Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift.
Theoretical biology & medical modelling 2007;4():42.
2007: Sims Kellie J; Alvarez-Vasquez Fernando; Voit Eberhard O; Hannun Yusuf A
A guide to biochemical systems modeling of sphingolipids for the biochemist.
Methods in enzymology 2007;432():319-50.
2006: Kitatani Kazuyuki; Idkowiak-Baldys Jolanta; Bielawski Jacek; Taha Tarek A; Jenkins Russell W; Senkal Can E; Ogretmen Besim; Obeid Lina M; Hannun Yusuf A
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
The Journal of biological chemistry 2006;281(48):36793-802.
2006: Dahm F; Nocito A; Bielawska A; Lang K S; Georgiev P; Asmis L M; Bielawski J; Madon J; Hannun Y A; Clavien P-A
Distribution and dynamic changes of sphingolipids in blood in response to platelet activation.
Journal of thrombosis and haemostasis : JTH 2006;4(12):2704-9.
2006: Clarke Christopher J; Hannun Yusuf A
Neutral sphingomyelinases and nSMase2: bridging the gaps.
Biochimica et biophysica acta 2006;1758(12):1893-901.
2006: Norris J S; Bielawska A; Day T; El-Zawahri A; ElOjeimy S; Hannun Y; Holman D; Hyer M; Landon C; Lowe S; Dong J Y; McKillop J; Norris K; Obeid L; Rubinchik S; Tavassoli M; Tomlinson S; Voelkel-Johnson C; Liu X
Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.
Cancer gene therapy 2006;13(12):1045-51.
2006: Taha Tarek A; El-Alwani Mazen; Hannun Yusuf A; Obeid Lina M
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease.
FEBS letters 2006;580(26):6047-54.
2006: Spassieva Stefka; Seo Jae-Gu; Jiang James C; Bielawski Jacek; Alvarez-Vasquez Fernando; Jazwinski S Michal; Hannun Yusuf A; Obeid Lina M
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.
The Journal of biological chemistry 2006;281(45):33931-8.
2006: Liu Xiang; Zeidan Youssef H; Elojeimy Saeed; Holman David H; El-Zawahry Ahmed M; Guo Gui-Wen; Bielawska Alicja; Bielawski Jacek; Szulc Zdzislaw; Rubinchik Semyon; Dong Jian-Yun; Keane Thomas E; Tavassoli Mahvash; Hannun Yusuf A; Norris James S
Involvement of sphingolipids in apoptin-induced cell killing.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):627-36.
2006: Szulc Zdzislaw M; Bielawski Jacek; Gracz Hanna; Gustilo Marietta; Mayroo Nalini; Hannun Yusuf A; Obeid Lina M; Bielawska Alicja
Tailoring structure-function and targeting properties of ceramides by site-specific cationization.
Bioorganic & medicinal chemistry 2006;14(21):7083-104.
2006: Liu Xiang; Elojeimy S; El-Zawahry A M; Holman D H; Bielawska A; Bielawski J; Rubinchik S; Guo G-W; Dong J-Y; Keane T; Hannun Y A; Tavassoli M; Norris James S
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):637-46.
2006: El Alwani Mazen; Wu Bill Xingjun; Obeid Lina M; Hannun Yusuf A
Bioactive sphingolipids in the modulation of the inflammatory response.
Pharmacology & therapeutics 2006;112(1):171-83.
2006: Clarke Christopher J; Snook Christopher F; Tani Motohiro; Matmati Nabil; Marchesini Norma; Hannun Yusuf A
The extended family of neutral sphingomyelinases.
Biochemistry 2006;45(38):11247-56.
2006: Samad Fahumiya; Hester Kelly D; Yang Guang; Hannun Yusuf A; Bielawski Jacek
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.
Diabetes 2006;55(9):2579-87.
2006: Snook C F; Jones J A; Hannun Y A
Sphingolipid-binding proteins.
Biochimica et biophysica acta 2006;1761(8):927-46.
2006: Elojeimy Saeed; Holman David H; Liu Xiang; El-Zawahry Ahmed; Villani Maristella; Cheng Joseph C; Mahdy Ayman; Zeidan Youssef; Bielwaska Alicja; Hannun Yusuf A; Norris James S
New insights on the use of desipramine as an inhibitor for acid ceramidase.
FEBS letters 2006;580(19):4751-6.
2006: Zeidan Youssef H; Pettus Benjamin J; Elojeimy Saeed; Taha Tarek; Obeid Lina M; Kawamori Toshihiko; Norris James S; Hannun Yusuf A
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
The Journal of biological chemistry 2006;281(34):24695-703.
2006: Idkowiak-Baldys Jolanta; Becker Kevin P; Kitatani Kazuyuki; Hannun Yusuf A
Dynamic sequestration of the recycling compartment by classical protein kinase C.
The Journal of biological chemistry 2006;281(31):22321-31.
2006: Bielawski Jacek; Szulc Zdzislaw M; Hannun Yusuf A; Bielawska Alicja
Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.
Methods (San Diego, Calif.) 2006;39(2):82-91.
2006: Dindo Daniel; Dahm Felix; Szulc Zdzislaw; Bielawska Alicja; Obeid Lina M; Hannun Yusuf A; Graf Rolf; Clavien Pierre-Alain
Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells.
Molecular cancer therapeutics 2006;5(6):1520-9.
2006: Senkal Can E; Ponnusamy Suriyan; Rossi Michael J; Sundararaj Kamala; Szulc Zdzislaw; Bielawski Jacek; Bielawska Alicja; Meyer Mario; Cobanoglu Bengu; Koybasi Serap; Sinha Debajyoti; Day Terry A; Obeid Lina M; Hannun Yusuf A; Ogretmen Besim
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1188-99.
2006: Taha Tarek Assad; Hannun Yusuf Awni; Obeid Lina Marie
Sphingosine kinase: biochemical and cellular regulation and role in disease.
Journal of biochemistry and molecular biology 2006;39(2):113-31.
2006: Taha Tarek A; Kitatani Kazuyuki; El-Alwani Mazen; Bielawski Jacek; Hannun Yusuf A; Obeid Lina M
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):482-4.
2006: Kono Mari; Dreier Jennifer L; Ellis Jessica M; Allende Maria L; Kalkofen Danielle N; Sanders Kathleen M; Bielawski Jacek; Bielawska Alicja; Hannun Yusuf A; Proia Richard L
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.
The Journal of biological chemistry 2006;281(11):7324-31.
2006: Kawamori Toshihiko; Osta Walid; Johnson Korey R; Pettus Benjamin J; Bielawski Jacek; Tanaka Takuji; Wargovich Michael J; Reddy Bandaru S; Hannun Yusuf A; Obeid Lina M; Zhou Daohong
Sphingosine kinase 1 is up-regulated in colon carcinogenesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):386-8.
2006: Galadari Sehamuddin; Wu Bill X; Mao Cungui; Roddy Patrick; El Bawab Samer; Hannun Yusuf A
Identification of a novel amidase motif in neutral ceramidase.
The Biochemical journal 2006;393(Pt 3):687-95.
2006: Cowart L Ashley; Okamoto Yasuo; Lu Xinghua; Hannun Yusuf A
Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae.
The Biochemical journal 2006;393(Pt 3):733-40.
2006: Bu Shizhong; Yamanaka Masayoshi; Pei Huiping; Bielawska Alicja; Bielawski Jacek; Hannun Yusuf A; Obeid Lina; Trojanowska Maria
Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(1):184-6.
2006: Sultan Iyad; Senkal Can E; Ponnusamy Suriyan; Bielawski Jacek; Szulc Zdzislaw; Bielawska Alicja; Hannun Yusuf A; Ogretmen Besim
Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
The Biochemical journal 2006;393(Pt 2):513-21.
2005: Osawa Yosuke; Hannun Yusuf A; Proia Richard L; Brenner David A
Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver.
Hepatology (Baltimore, Md.) 2005;42(6):1320-8.
2005: Cowart L A; Hannun Y A
Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response.
Biochemical Society transactions 2005;33(Pt 5):1166-9.
2005: Jones Jeffrey A; Rawles Robert; Hannun Yusuf A
Identification of a novel phosphatidic acid binding domain in protein phosphatase-1.
Biochemistry 2005;44(40):13235-45.
2005: Voelkel-Johnson Christina; Hannun Yusuf A; El-Zawahry Ahmed
Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein.
Molecular cancer therapeutics 2005;4(9):1320-7.
2005: Pettus Benjamin J; Kitatani Kazuyuki; Chalfant Charles E; Taha Tarek A; Kawamori Toshihiko; Bielawski Jacek; Obeid Lina M; Hannun Yusuf A
The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.
Molecular pharmacology 2005;68(2):330-5.
2005: Osawa Yosuke; Uchinami Hiroshi; Bielawski Jacek; Schwabe Robert F; Hannun Yusuf A; Brenner David A
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
The Journal of biological chemistry 2005;280(30):27879-87.
2005: Becker K P; Hannun Y A
Protein kinase C and phospholipase D: intimate interactions in intracellular signaling.
Cellular and molecular life sciences : CMLS 2005;62(13):1448-61.
2005: Novgorodov Sergei A; Szulc Zdzislaw M; Luberto Chiara; Jones Jeffrey A; Bielawski Jacek; Bielawska Alicja; Hannun Yusuf A; Obeid Lina M
Positively charged ceramide is a potent inducer of mitochondrial permeabilization.
The Journal of biological chemistry 2005;280(16):16096-105.
2005: Taha Tarek A; Kitatani Kazuyuki; Bielawski Jacek; Cho Wonhwa; Hannun Yusuf A; Obeid Lina M
Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.
The Journal of biological chemistry 2005;280(17):17196-202.
2005: Pinto F R; Cowart L Ashley; Hannun Yusuf A; Rohrer B; Almeida J S
Local correlation of expression profiles with gene annotations--proof of concept for a general conciliatory method.
Bioinformatics (Oxford, England) 2005;21(7):1037-45.
2005: Hu Wei; Xu Ruijuan; Zhang Guofeng; Jin Junfei; Szulc Zdzislaw M; Bielawski Jacek; Hannun Yusuf A; Obeid Lina M; Mao Cungui
Golgi fragmentation is associated with ceramide-induced cellular effects.
Molecular biology of the cell 2005;16(3):1555-67.
2005: Birbes Helene; Luberto Chiara; Hsu Yi-Te; El Bawab Samer; Hannun Yusuf A; Obeid Lina M
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.
The Biochemical journal 2005;386(Pt 3):445-51.
2005: Vaena de Avalos Silvia; Su Xuefeng; Zhang Mei; Okamoto Yasuo; Dowhan William; Hannun Yusuf A
The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(8):7170-7.
2005: Alvarez-Vasquez Fernando; Sims Kellie J; Cowart L Ashley; Okamoto Yasuo; Voit Eberhard O; Hannun Yusuf A
Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae.
Nature 2005;433(7024):425-30.
2005: Rossi Michael J; Sundararaj Kamala; Koybasi Serap; Phillips Monique S; Szulc Zdzislaw M; Bielawska Alicja; Day Terry A; Obeid Lina M; Hannun Yusuf A; Ogretmen Besim
Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2005;132(1):55-62.
2005: Becker Kevin P; Kitatani Kazuyuki; Idkowiak-Baldys Jolanta; Bielawski Jacek; Hannun Yusuf A
Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway.
The Journal of biological chemistry 2005;280(4):2606-12.
2004: Yamanaka Masayoshi; Shegogue Daniel; Pei Heuping; Bu Shizhong; Bielawska Alicja; Bielawski Jacek; Pettus Benjamin; Hannun Yusuf A; Obeid Lina; Trojanowska Maria
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
The Journal of biological chemistry 2004;279(52):53994-4001.
2004: Koybasi Serap; Senkal Can E; Sundararaj Kamala; Spassieva Stefka; Bielawski Jacek; Osta Walid; Day Terry A; Jiang James C; Jazwinski S Michal; Hannun Yusuf A; Obeid Lina M; Ogretmen Besim
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
The Journal of biological chemistry 2004;279(43):44311-9.
2004: Osta Walid A; Chen Yian; Mikhitarian Kaidi; Mitas Michael; Salem Mohamed; Hannun Yusuf A; Cole David J; Gillanders William E
EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy.
Cancer research 2004;64(16):5818-24.
2004: Futerman Anthony H; Hannun Yusuf A
The complex life of simple sphingolipids.
EMBO reports 2004;5(8):777-82.
2004: Ogretmen Besim; Hannun Yusuf A
Biologically active sphingolipids in cancer pathogenesis and treatment.
Nature reviews. Cancer 2004;4(8):604-16.
2004: Becker Kevin P; Hannun Yusuf A
Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D.
The Journal of biological chemistry 2004;279(27):28251-6.
2004: Pettus B J; Chalfant C E; Hannun Y A
Sphingolipids in inflammation: roles and implications.
Current molecular medicine 2004;4(4):405-18.
2004: Marchesini Norma; Osta Walid; Bielawski Jacek; Luberto Chiara; Obeid Lina M; Hannun Yusuf A
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.
The Journal of biological chemistry 2004;279(24):25101-11.
2004: Bai Aiping; Meier G Patrick; Wang Yong; Luberto Chiara; Hannun Yusuf A; Zhou Daohong
Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells.
The Journal of pharmacology and experimental therapeutics 2004;309(3):1051-9.
2004: Heung Lena J; Luberto Chiara; Plowden Allyson; Hannun Yusuf A; Del Poeta Maurizio
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans.
The Journal of biological chemistry 2004;279(20):21144-53.
2004: Taha Tarek A; Osta Walid; Kozhaya Lina; Bielawski Jacek; Johnson Korey R; Gillanders William E; Dbaibo Ghassan S; Hannun Yusuf A; Obeid Lina M
Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.
The Journal of biological chemistry 2004;279(19):20546-54.
2004: Vaena de Avalos Silvia; Okamoto Yasuo; Hannun Yusuf A
Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae.
The Journal of biological chemistry 2004;279(12):11537-45.
2004: Pettus Benjamin J; Bielawska Alicja; Subramanian Preeti; Wijesinghe Dayanjan S; Maceyka Michael; Leslie Christina C; Evans John H; Freiberg Jessica; Roddy Patrick; Hannun Yusuf A; Chalfant Charles E
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.
The Journal of biological chemistry 2004;279(12):11320-6.
2004: Chalfant Charles E; Szulc Zdzislaw; Roddy Patrick; Bielawska Alicja; Hannun Yusuf A
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
Journal of lipid research 2004;45(3):496-506.
2004: Marchesini Norma; Hannun Yusuf A
Acid and neutral sphingomyelinases: roles and mechanisms of regulation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(1):27-44.
2004: Hannun Yusuf A; Luberto Chiara
Lipid metabolism: ceramide transfer protein adds a new dimension.
Current biology : CB 2004;14(4):R163-5.
2004: Alvarez-Vasquez Fernando; Sims Kellie J; Hannun Yusuf A; Voit Eberhard O
Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models.
Journal of theoretical biology 2004;226(3):265-91.
2004: Sundararaj Kamala P; Wood Rachel E; Ponnusamy Suriyan; Salas Arelis M; Szulc Zdzislaw; Bielawska Alicia; Obeid Lina M; Hannun Yusuf A; Ogretmen Besim
Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase.
The Journal of biological chemistry 2004;279(7):6152-62.
2004: Meng Aimin; Luberto Chiara; Meier Patrick; Bai Aiping; Yang Xiaofeng; Hannun Yusuf A; Zhou Daohong
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells.
Experimental cell research 2004;292(2):385-92.
2004: Pettus Benjamin J; Baes Myriam; Busman Mark; Hannun Yusuf A; Van Veldhoven Paul P
Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders.
Rapid communications in mass spectrometry : RCM 2004;18(14):1569-74.
2004: Pettus Benjamin J; Kroesen Bart-Jan; Szulc Zdizslaw M; Bielawska Alicia; Bielawski Jacek; Hannun Yusuf A; Busman Mark
Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(5):577-83.
2003: Becker Kevin P; Hannun Yusuf A
cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.
The Journal of biological chemistry 2003;278(52):52747-54.
2003: Obeid Lina M; Hannun Yusuf A
Ceramide, stress, and a "LAG" in aging.
Science of aging knowledge environment : SAGE KE 2003;2003(39):PE27.
2003: Luberto Chiara; Martinez-Mariño Beatriz; Taraskiewicz Daniel; Bolaños Benjamin; Chitano Pasquale; Toffaletti Dena L; Cox Gary M; Perfect John R; Hannun Yusuf A; Balish Edward; Del Poeta Maurizio
Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans.
The Journal of clinical investigation 2003;112(7):1080-94.
2003: Pettus Benjamin J; Bielawska Alicja; Spiegel Sarah; Roddy Patrick; Hannun Yusuf A; Chalfant Charles E
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.
The Journal of biological chemistry 2003;278(40):38206-13.
2003: Pettus Benjamin J; Bielawski Jacek; Porcelli Anna M; Reames Davis L; Johnson Korey R; Morrow Jason; Chalfant Charles E; Obeid Lina M; Hannun Yusuf A
The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(11):1411-21.
2003: Luberto Chiara; Stonehouse Martin J; Collins Elizabeth A; Marchesini Norma; El-Bawab Samer; Vasil Adriana I; Vasil Michael L; Hannun Yusuf A
Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme.
The Journal of biological chemistry 2003;278(35):32733-43.
2003: Cowart L Ashley; Okamoto Yasuo; Pinto Francisco R; Gandy Jason L; Almeida Jonas S; Hannun Yusuf A
Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling.
The Journal of biological chemistry 2003;278(32):30328-38.
2003: Okamoto Yasuo; Vaena de Avalos Silvia; Hannun Yusuf A
Functional analysis of ISC1 by site-directed mutagenesis.
Biochemistry 2003;42(25):7855-62.
2003: Schanberg Saul M; Ingledue Vickie F; Lee Joanna Y; Hannun Yusuf A; Bartolome Jorge V
PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1026-30.
2003: Hyer Marc L; Sudarshan Sunil; Schwartz David A; Hannun Yusuf; Dong Jian-yun; Norris James S
Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression.
Cancer gene therapy 2003;10(4):330-9.
2003: Kroesen Bart-Jan; Jacobs Susan; Pettus Benjamin J; Sietsma Hannie; Kok Jan Willem; Hannun Yusuf A; de Leij Lou F M H
BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome.
The Journal of biological chemistry 2003;278(17):14723-31.
2003: Marchesini Norma; Luberto Chiara; Hannun Yusuf A
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.
The Journal of biological chemistry 2003;278(16):13775-83.
2003: Sato Madoka; Markiewicz Margaret; Yamanaka Masoyoshi; Bielawska Alicja; Mao Cungui; Obeid Lina M; Hannun Yusuf A; Trojanowska Maria
Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.
The Journal of biological chemistry 2003;278(11):9276-82.
2003: Pettus Benjamin J; Bielawska Alicia; Kroesen Bart-Jan; Moeller Peter D R; Szulc Zdzislaw M; Hannun Yusuf A; Busman Mark
Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry.
Rapid communications in mass spectrometry : RCM 2003;17(11):1203-11.
2002: Pettus Benjamin J; Chalfant Charles E; Hannun Yusuf A
Ceramide in apoptosis: an overview and current perspectives.
Biochimica et biophysica acta 2002;1585(2-3):114-25.
2002: Cowart L Ashley; Szulc Zdzislaw; Bielawska Alicja; Hannun Yusuf A
Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies.
Journal of lipid research 2002;43(12):2042-8.
2002: Okamoto Yasuo; Vaena De Avalos Silvia; Hannun Yusuf A
Structural requirements for selective binding of ISC1 to anionic phospholipids.
The Journal of biological chemistry 2002;277(48):46470-7.
2002: Jenkins Gary M; Cowart L Ashley; Signorelli Paola; Pettus Benjamin J; Chalfant Charles E; Hannun Yusuf A
Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.
The Journal of biological chemistry 2002;277(45):42572-8.
2002: Okamoto Yasuo; Obeid Lina M; Hannun Yusuf A
Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.
FEBS letters 2002;530(1-3):104-8.
2002: Luberto Chiara; Hassler Daniel F; Signorelli Paola; Okamoto Yasuo; Sawai Hirofumi; Boros Eric; Hazen-Martin Debra J; Obeid Lina M; Hannun Yusuf A; Smith Gary K
Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.
The Journal of biological chemistry 2002;277(43):41128-39.
2002: Johnson Korey R; Becker Kevin P; Facchinetti Maria Marta; Hannun Yusuf A; Obeid Lina M
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA).
The Journal of biological chemistry 2002;277(38):35257-62.
2002: Luberto Chiara; Kraveka Jacqueline M; Hannun Yusuf A
Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology.
Neurochemical research 2002;27(7-8):609-17.
2002: Hannun Yusuf A; Obeid Lina M
The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind.
The Journal of biological chemistry 2002;277(29):25847-50.
2002: Jones Jeffrey A; Hannun Yusuf A
Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid.
The Journal of biological chemistry 2002;277(18):15530-8.
2002: Raisova Monika; Goltz Gerit; Bektas Meryem; Bielawska Alicja; Riebeling Christian; Hossini Amir M; Eberle Jürgen; Hannun Yusuf A; Orfanos Constantin E; Geilen Christoph C
Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.
FEBS letters 2002;516(1-3):47-52.
2002: Ogretmen Besim; Pettus Benjamin J; Rossi Michael J; Wood Rachel; Usta Julnar; Szulc Zdzislaw; Bielawska Alicia; Obeid Lina M; Hannun Yusuf A
Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.
The Journal of biological chemistry 2002;277(15):12960-9.
2002: Chalfant Charles E; Rathman Kristin; Pinkerman Ryan L; Wood Rachel E; Obeid Lina M; Ogretmen Besim; Hannun Yusuf A
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
The Journal of biological chemistry 2002;277(15):12587-95.
2002: El Bawab Samer; Usta Julnar; Roddy Patrick; Szulc Zdzislaw M; Bielawska Alicja; Hannun Yusuf A
Substrate specificity of rat brain ceramidase.
Journal of lipid research 2002;43(1):141-8.
2002: Argraves Kelley M; Obeid Lina M; Hannun Yusuf A
Sphingolipids in vascular biology.
Advances in experimental medicine and biology 2002;507():439-44.
2002: Birbes Helene; El Bawab Samer; Obeid Lina M; Hannun Yusuf A
Mitochondria and ceramide: intertwined roles in regulation of apoptosis.
Advances in enzyme regulation 2002;42():113-29.
2002: el Bawab Samer; Mao Cungui; Obeid Lina M; Hannun Yasuf A
Ceramidases in the regulation of ceramide levels and function.
Sub-cellular biochemistry 2002;36():187-205.
2002: Signorelli Paola; Hannun Yusuf A
Analysis and quantitation of ceramide.
Methods in enzymology 2002;345():275-94.
2001: Ogretmen B; Hannun Y A
Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2001;4(6):368-77.
2001: Birbes H; El Bawab S; Hannun Y A; Obeid L M
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(14):2669-79.
2001: Bielawska A; Perry D K; Hannun Y A
Determination of ceramides and diglycerides by the diglyceride kinase assay.
Analytical biochemistry 2001;298(2):141-50.
2001: Signorelli P; Luberto C; Hannun Y A
Ceramide inhibition of NF-kappaB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(13):2401-14.
2001: Chalfant C E; Ogretmen B; Galadari S; Kroesen B J; Pettus B J; Hannun Y A
FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1.
The Journal of biological chemistry 2001;276(48):44848-55.
2001: Hayter H L; Pettus B J; Ito F; Obeid L M; Hannun Y A
TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells.
FEBS letters 2001;507(2):151-6.
2001: Chung N; Mao C; Heitman J; Hannun Y A; Obeid L M
Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(38):35614-21.
2001: Boujaoude L C; Bradshaw-Wilder C; Mao C; Cohn J; Ogretmen B; Hannun Y A; Obeid L M
Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate.
The Journal of biological chemistry 2001;276(38):35258-64.
2001: Dbaibo G S; El-Assaad W; Krikorian A; Liu B; Diab K; Idriss N Z; El-Sabban M; Driscoll T A; Perry D K; Hannun Y A
Ceramide generation by two distinct pathways in tumor necrosis factor alpha-induced cell death.
FEBS letters 2001;503(1):7-12.
2001: Ogretmen B; Kraveka J M; Schady D; Usta J; Hannun Y A; Obeid L M
Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line.
The Journal of biological chemistry 2001;276(35):32506-14.
2001: Ogretmen B; Schady D; Usta J; Wood R; Kraveka J M; Luberto C; Birbes H; Hannun Y A; Obeid L M
Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells.
The Journal of biological chemistry 2001;276(27):24901-10.
2001: El Bawab S; Birbes H; Roddy P; Szulc Z M; Bielawska A; Hannun Y A
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.
The Journal of biological chemistry 2001;276(20):16758-66.
2001: Hannun Y A; Luberto C; Argraves K M
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
Biochemistry 2001;40(16):4893-903.
2001: Kroesen B J; Pettus B; Luberto C; Busman M; Sietsma H; de Leij L; Hannun Y A
Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria.
The Journal of biological chemistry 2001;276(17):13606-14.
2001: Jenkins G M; Hannun Y A
Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(11):8574-81.
2001: Selzner M; Bielawska A; Morse M A; Rüdiger H A; Sindram D; Hannun Y A; Clavien P A
Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer.
Cancer research 2001;61(3):1233-40.
2001: Luberto C; Toffaletti D L; Wills E A; Tucker S C; Casadevall A; Perfect J R; Hannun Y A; Del Poeta M
Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.
Genes & development 2001;15(2):201-12.
2000: Sawai H; Okamoto Y; Luberto C; Mao C; Bielawska A; Domae N; Hannun Y A
Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.
The Journal of biological chemistry 2000;275(50):39793-8.
2000: Lee J Y; Hannun Y A; Obeid L M
Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.
The Journal of biological chemistry 2000;275(38):29290-8.
2000: El Bawab S; Roddy P; Qian T; Bielawska A; Lemasters J J; Hannun Y A
Molecular cloning and characterization of a human mitochondrial ceramidase.
The Journal of biological chemistry 2000;275(28):21508-13.
2000: Bae S S; Perry D K; Oh Y S; Choi J H; Galadari S H; Ghayur T; Ryu S H; Hannun Y A; Suh P G
Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(9):1083-92.
2000: Feng X; Becker K P; Stribling S D; Peters K G; Hannun Y A
Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation.
The Journal of biological chemistry 2000;275(22):17024-34.
2000: Chung N; Jenkins G; Hannun Y A; Heitman J; Obeid L M
Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis.
The Journal of biological chemistry 2000;275(23):17229-32.
2000: Luberto C; Yoo D S; Suidan H S; Bartoli G M; Hannun Y A
Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts.
The Journal of biological chemistry 2000;275(19):14760-6.
2000: Idriss H T; Hannun Y A; Boulpaep E; Basavappa S
Regulation of volume-activated chloride channels by P-glycoprotein: phosphorylation has the final say!
The Journal of physiology 2000;524 Pt 3():629-36.
2000: Perry D K; Carton J; Shah A K; Meredith F; Uhlinger D J; Hannun Y A
Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis.
The Journal of biological chemistry 2000;275(12):9078-84.
2000: Van Tiel C M; Luberto C; Snoek G T; Hannun Y A; Wirtz K W
Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta.
The Biochemical journal 2000;346 Pt 2():537-43.
2000: Hannun Y A; Luberto C
Ceramide in the eukaryotic stress response.
Trends in cell biology 2000;10(2):73-80.
2000: Chalfant C E; Kishikawa K; Bielawska A; Hannun Y A
Analysis of ceramide-activated protein phosphatases.
Methods in enzymology 2000;312():420-8.
2000: Luberto C; Hannun Y A
Use of short-chain ceramides.
Methods in enzymology 2000;312():407-20.
2000: Smith E R; Merrill A H; Obeid L M; Hannun Y A
Effects of sphingosine and other sphingolipids on protein kinase C.
Methods in enzymology 2000;312():361-73.
2000: Perry D K; Bielawska A; Hannun Y A
Quantitative determination of ceramide using diglyceride kinase.
Methods in enzymology 2000;312():22-31.
2000: Bielawska A; Szulc Z; Hannun Y A
Synthesis of key precursors of radiolabeled sphingolipids.
Methods in enzymology 2000;311():518-35.
2000: Bielawska A; Hannun Y A
Preparation of radiolabeled ceramides and phosphosphingolipids.
Methods in enzymology 2000;311():499-518.
2000: Liu B; Hannun Y A
Sphingomyelinase assay using radiolabeled substrate.
Methods in enzymology 2000;311():164-7.
2000: Liu B; Hannun Y A
Purification of rat brain membrane neutral sphingomyelinase.
Methods in enzymology 2000;311():156-64.
1999: Juo P; Woo M S; Kuo C J; Signorelli P; Biemann H P; Hannun Y A; Blenis J
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(12):797-804.
1999: Sawai H; Domae N; Nagan N; Hannun Y A
Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.
The Journal of biological chemistry 1999;274(53):38131-9.
1999: Sawai H; Hannun Y A
Ceramide and sphingomyelinases in the regulation of stress responses.
Chemistry and physics of lipids 1999;102(1-2):141-7.
1999: El Bawab S; Bielawska A; Hannun Y A
Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain.
The Journal of biological chemistry 1999;274(39):27948-55.
1999: Zhang J; Hannun Y A; Obeid L M
A novel assay for apoptotic body formation and membrane release during apoptosis.
Cell death and differentiation 1999;6(7):596-8.
1999: Kishikawa K; Chalfant C E; Perry D K; Bielawska A; Hannun Y A
Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses.
The Journal of biological chemistry 1999;274(30):21335-41.
1999: Chalfant C E; Kishikawa K; Mumby M C; Kamibayashi C; Bielawska A; Hannun Y A
Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.
The Journal of biological chemistry 1999;274(29):20313-7.
1999: Perry D K; Hannun Y A
The use of diglyceride kinase for quantifying ceramide.
Trends in biochemical sciences 1999;24(6):226-7.
1999: Kolesnick R; Hannun Y A
Ceramide and apoptosis.
Trends in biochemical sciences 1999;24(6):224-5; author reply 227.
1999: Zhang J; Reedy M C; Hannun Y A; Obeid L M
Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis.
The Journal of cell biology 1999;145(1):99-108.
1999: Luberto C; Hannun Y A
Sphingolipid metabolism in the regulation of bioactive molecules.
Lipids 1999;34 Suppl():S5-11.
1998: Liu B; Hassler D F; Smith G K; Weaver K; Hannun Y A
Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain.
The Journal of biological chemistry 1998;273(51):34472-9.
1998: Perry D K; Hannun Y A
The role of ceramide in cell signaling.
Biochimica et biophysica acta 1998;1436(1-2):233-43.
1998: Dbaibo G S; Hannun Y A
Signal transduction and the regulation of apoptosis: roles of ceramide.
Apoptosis : an international journal on programmed cell death 1998;3(5):317-34.
1998: Feng X; Hannun Y A
An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane.
The Journal of biological chemistry 1998;273(41):26870-4.
1998: Zhang J; Driscoll T A; Hannun Y A; Obeid L M
Regulation of membrane release in apoptosis.
The Biochemical journal 1998;334 ( Pt 2)():479-85.
1998: Galadari S; Kishikawa K; Kamibayashi C; Mumby M C; Hannun Y A
Purification and characterization of ceramide-activated protein phosphatases.
Biochemistry 1998;37(32):11232-8.
1998: Dbaibo G S; Pushkareva M Y; Rachid R A; Alter N; Smyth M J; Obeid L M; Hannun Y A
p53-dependent ceramide response to genotoxic stress.
The Journal of clinical investigation 1998;102(2):329-39.
1998: Perry S W; Hamilton J A; Tjoelker L W; Dbaibo G; Dzenko K A; Epstein L G; Hannun Y; Whittaker J S; Dewhurst S; Gelbard H A
Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis.
The Journal of biological chemistry 1998;273(28):17660-4.
1998: Luberto C; Hannun Y A
Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
The Journal of biological chemistry 1998;273(23):14550-9.
1998: Laethem R M; Hannun Y A; Jayadev S; Sexton C J; Strum J C; Sundseth R; Smith G K
Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843.
Blood 1998;91(11):4350-60.
1998: Liu B; Andrieu-Abadie N; Levade T; Zhang P; Obeid L M; Hannun Y A
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
The Journal of biological chemistry 1998;273(18):11313-20.
1998: Feng X; Zhang J; Barak L S; Meyer T; Caron M G; Hannun Y A
Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.
The Journal of biological chemistry 1998;273(17):10755-62.
1998: Flores I; Martinez-A C; Hannun Y A; Mérida I
Dual role of ceramide in the control of apoptosis following IL-2 withdrawal.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3528-33.
1998: Dbaibo G S; Hannun Y A
Cytokine response modifier A (CrmA): a strategically deployed viral weapon.
Clinical immunology and immunopathology 1998;86(2):134-40.
1998: Rizzieri K E; Hannun Y A
Sphingolipid metabolism, apoptosis and resistance to cytotoxic agents: can we interfere?
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998;1(6):359-76.
1997: Jenkins G M; Richards A; Wahl T; Mao C; Obeid L; Hannun Y
Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae.
The Journal of biological chemistry 1997;272(51):32566-72.
1997: Hannun Y A; Obeid L M
Ceramide and the eukaryotic stress response.
Biochemical Society transactions 1997;25(4):1171-5.
1997: Bielawska A E; Shapiro J P; Jiang L; Melkonyan H S; Piot C; Wolfe C L; Tomei L D; Hannun Y A; Umansky S R
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion.
The American journal of pathology 1997;151(5):1257-63.
1997: Mao C; Wadleigh M; Jenkins G M; Hannun Y A; Obeid L M
Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase.
The Journal of biological chemistry 1997;272(45):28690-4.
1997: Saba J D; Nara F; Bielawska A; Garrett S; Hannun Y A
The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase.
The Journal of biological chemistry 1997;272(42):26087-90.
1997: Lee T G; Park J B; Lee S D; Hong S; Kim J H; Kim Y; Yi K S; Bae S; Hannun Y A; Obeid L M; Suh P G; Ryu S H
Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells.
Biochimica et biophysica acta 1997;1347(2-3):199-204.
1997: Wieder T; Geilen C C; Kolter T; Sadeghlar F; Sandhoff K; Brossmer R; Ihrig P; Perry D; Orfanos C E; Hannun Y A
Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues.
FEBS letters 1997;411(2-3):260-4.
1997: Perry D K; Smyth M J; Stennicke H R; Salvesen G S; Duriez P; Poirier G G; Hannun Y A
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis.
The Journal of biological chemistry 1997;272(30):18530-3.
1997: Jayadev S; Hayter H L; Andrieu N; Gamard C J; Liu B; Balu R; Hayakawa M; Ito F; Hannun Y A
Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells.
The Journal of biological chemistry 1997;272(27):17196-203.
1997: Gamard C J; Dbaibo G S; Liu B; Obeid L M; Hannun Y A
Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.
The Journal of biological chemistry 1997;272(26):16474-81.
1997: Lai T S; Bielawska A; Peoples K A; Hannun Y A; Greenberg C S
Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
The Journal of biological chemistry 1997;272(26):16295-300.
1997: Liu B; Hannun Y A
Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione.
The Journal of biological chemistry 1997;272(26):16281-7.
1997: Wang Y; Roman R; Schlenker T; Hannun Y A; Raymond J; Fitz J G
Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line.
The Journal of clinical investigation 1997;99(12):2890-7.
1997: Bradham C A; Stachlewitz R F; Gao W; Qian T; Jayadev S; Jenkins G; Hannun Y; Lemasters J J; Thurman R G; Brenner D A
Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases.
Hepatology (Baltimore, Md.) 1997;25(5):1128-35.
1997: Zhang P; Liu B; Jenkins G M; Hannun Y A; Obeid L M
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis.
The Journal of biological chemistry 1997;272(15):9609-12.
1997: Hannun Y A
Apoptosis and the dilemma of cancer chemotherapy.
Blood 1997;89(6):1845-53.
1997: Puranam K; Qian W H; Nikbakht K; Venable M; Obeid L; Hannun Y; Boustany R M
Upregulation of Bcl-2 and elevation of ceramide in Batten disease.
Neuropediatrics 1997;28(1):37-41.
1997: Dbaibo G S; Perry D K; Gamard C J; Platt R; Poirier G G; Obeid L M; Hannun Y A
Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway.
The Journal of experimental medicine 1997;185(3):481-90.
1997: Perry D K; Smyth M J; Wang H G; Reed J C; Duriez P; Poirier G G; Obeid L M; Hannun Y A
Bcl-2 acts upstream of the PARP protease and prevents its activation.
Cell death and differentiation 1997;4(1):29-33.
1997: Liu B; Maher R J; De Jonckheere J P; Popat R U; Stojakovic S; Hannun Y A; Porter A T; Honn K V
12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha.
Advances in experimental medicine and biology 1997;400B():707-18.
1997: Hannun Y A
Sphingolipid second messengers: tumor suppressor lipids.
Advances in experimental medicine and biology 1997;400A():305-12.
1997: Hannun Y A; Obeid L M
Mechanisms of ceramide-mediated apoptosis.
Advances in experimental medicine and biology 1997;407():145-9.
1997: Smyth M J; Obeid L M; Hannun Y A
Ceramide: a novel lipid mediator of apoptosis.
Advances in pharmacology (San Diego, Calif.) 1997;41():133-54.
1996: Hannun Y A
Functions of ceramide in coordinating cellular responses to stress.
Science (New York, N.Y.) 1996;274(5294):1855-9.
1996: Jayadev S; Hannun Y A
Ceramide: role in growth inhibitory cascades.
Journal of lipid mediators and cell signalling 1996;14(1-3):295-301.
1996: Jideama N M; Noland T A; Raynor R L; Blobe G C; Fabbro D; Kazanietz M G; Blumberg P M; Hannun Y A; Kuo J F
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties.
The Journal of biological chemistry 1996;271(38):23277-83.
1996: Kawamura A; Berova N; Dirsch V; Mangoni A; Nakanishi K; Schwartz G; Bielawska A; Hannun Y; Kitagawa I
Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines.
Bioorganic & medicinal chemistry 1996;4(7):1035-43.
1996: Wang Y; Sostman A; Roman R; Stribling S; Vigna S; Hannun Y; Raymond J; Fitz J G
Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism.
The Journal of biological chemistry 1996;271(30):18107-13.
1996: Linardic C M; Jayadev S; Hannun Y A
Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(6):765-74.
1996: Blobe G C; Stribling D S; Fabbro D; Stabel S; Hannun Y A
Protein kinase C beta II specifically binds to and is activated by F-actin.
The Journal of biological chemistry 1996;271(26):15823-30.
1996: Lee J Y; Hannun Y A; Obeid L M
Ceramide inactivates cellular protein kinase Calpha.
The Journal of biological chemistry 1996;271(22):13169-74.
1996: Bielawska A; Greenberg M S; Perry D; Jayadev S; Shayman J A; McKay C; Hannun Y A
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase.
The Journal of biological chemistry 1996;271(21):12646-54.
1996: Smyth M J; Perry D K; Zhang J; Poirier G G; Hannun Y A; Obeid L M
prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.
The Biochemical journal 1996;316 ( Pt 1)():25-8.
1996: Zhang J; Alter N; Reed J C; Borner C; Obeid L M; Hannun Y A
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5325-8.
1996: Hayakawa M; Jayadev S; Tsujimoto M; Hannun Y A; Ito F
Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2.
Biochemical and biophysical research communications 1996;220(3):681-6.
1996: Saba J D; Obeid L M; Hannun Y A
Ceramide: an intracellular mediator of apoptosis and growth suppression.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):233-40; discussion 240-1.
1996: Blobe G C; Stribling S; Obeid L M; Hannun Y A
Protein kinase C isoenzymes: regulation and function.
Cancer surveys 1996;27():213-48.
1995: Dobrowsky R T; Jenkins G M; Hannun Y A
Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors.
The Journal of biological chemistry 1995;270(38):22135-42.
1995: Dbaibo G S; Wolff R A; Obeid L M; Hannun Y A
Activation of a retinoblastoma-protein-dependent pathway by sphingosine.
The Biochemical journal 1995;310 ( Pt 2)():453-9.
1995: Liu B; Khan W A; Hannun Y A; Timar J; Taylor J D; Lundy S; Butovich I; Honn K V
12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9323-7.
1995: Westwick J K; Bielawska A E; Dbaibo G; Hannun Y A; Brenner D A
Ceramide activates the stress-activated protein kinases.
The Journal of biological chemistry 1995;270(39):22689-92.
1995: Laulederkind S J; Bielawska A; Raghow R; Hannun Y A; Ballou L R
Ceramide induces interleukin 6 gene expression in human fibroblasts.
The Journal of experimental medicine 1995;182(2):599-604.
1995: Tepper C G; Jayadev S; Liu B; Bielawska A; Wolff R; Yonehara S; Hannun Y A; Seldin M F
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8443-7.
1995: Obeid L M; Hannun Y A
Ceramide: a stress signal and mediator of growth suppression and apoptosis.
Journal of cellular biochemistry 1995;58(2):191-8.
1995: Pushkareva M; Obeid L M; Hannun Y A
Ceramide: an endogenous regulator of apoptosis and growth suppression.
Immunology today 1995;16(6):294-7.
1995: Khan W A; Blobe G C; Hannun Y A
Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C.
Cellular signalling 1995;7(3):171-84.
1995: Dbaibo G S; Pushkareva M Y; Jayadev S; Schwarz J K; Horowitz J M; Obeid L M; Hannun Y A
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1347-51.
1995: Pushkareva M; Chao R; Bielawska A; Merrill A H; Crane H M; Lagu B; Liotta D; Hannun Y A
Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine.
Biochemistry 1995;34(6):1885-92.
1995: Jayadev S; Liu B; Bielawska A E; Lee J Y; Nazaire F; Pushkareva MYu; Obeid L M; Hannun Y A
Role for ceramide in cell cycle arrest.
The Journal of biological chemistry 1995;270(5):2047-52.
1995: Blobe G C; Khan W A; Hannun Y A
Protein kinase C: cellular target of the second messenger arachidonic acid?
Prostaglandins, leukotrienes, and essential fatty acids 1995;52(2-3):129-35.
1995: Hannun Y A; Obeid L M
Ceramide: an intracellular signal for apoptosis.
Trends in biochemical sciences 1995;20(2):73-7.
1994: Blobe G C; Obeid L M; Hannun Y A
Regulation of protein kinase C and role in cancer biology.
Cancer metastasis reviews 1994;13(3-4):411-31.
1994: Alcantara O; Obeid L; Hannun Y; Ponka P; Boldt D H
Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin.
Blood 1994;84(10):3510-7.
1994: Linardic C M; Hannun Y A
Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.
The Journal of biological chemistry 1994;269(38):23530-7.
1994: Dobrowsky R T; Werner M H; Castellino A M; Chao M V; Hannun Y A
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
Science (New York, N.Y.) 1994;265(5178):1596-9.
1994: Liu B; Maher R J; Hannun Y A; Porter A T; Honn K V
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Journal of the National Cancer Institute 1994;86(15):1145-51.
1994: Wolff R A; Dobrowsky R T; Bielawska A; Obeid L M; Hannun Y A
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.
The Journal of biological chemistry 1994;269(30):19605-9.
1994: Khan W A; Blobe G C; Richards A L; Hannun Y A
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
The Journal of biological chemistry 1994;269(13):9729-35.
1994: Gamard C J; Blobe G C; Hannun Y A; Obeid L M
Specific role for protein kinase C beta in cell differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(4):405-9.
1994: Pushkareva MYu; Hannun Y A
Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine.
Biochimica et biophysica acta 1994;1221(1):54-60.
1994: Okazaki T; Bielawska A; Domae N; Bell R M; Hannun Y A
Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
The Journal of biological chemistry 1994;269(6):4070-7.
1994: Jayadev S; Linardic C M; Hannun Y A
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
The Journal of biological chemistry 1994;269(8):5757-63.
1994: Hannun Y A
The sphingomyelin cycle and the second messenger function of ceramide.
The Journal of biological chemistry 1994;269(5):3125-8.
1993: Hannun Y A; Linardic C M
Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids.
Biochimica et biophysica acta 1993;1154(3-4):223-36.
1993: Bielawska A; Crane H M; Liotta D; Obeid L M; Hannun Y A
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.
The Journal of biological chemistry 1993;268(35):26226-32.
1993: Pushkareva MYu; Bielawska A; Menaldiv D; Liotta D; Hannun Y A
Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids.
The Biochemical journal 1993;294 ( Pt 3)():699-703.
1993: Dbaibo G S; Obeid L M; Hannun Y A
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
The Journal of biological chemistry 1993;268(24):17762-6.
1993: Middleton J P; Khan W A; Collinsworth G; Hannun Y A; Medford R M
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
The Journal of biological chemistry 1993;268(21):15958-64.
1993: Dobrowsky R T; Kamibayashi C; Mumby M C; Hannun Y A
Ceramide activates heterotrimeric protein phosphatase 2A.
The Journal of biological chemistry 1993;268(21):15523-30.
1993: Fishbein J D; Dobrowsky R T; Bielawska A; Garrett S; Hannun Y A
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae.
The Journal of biological chemistry 1993;268(13):9255-61.
1993: Blobe G C; Khan W A; Halpern A E; Obeid L M; Hannun Y A
Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing.
The Journal of biological chemistry 1993;268(14):10627-35.
1993: Obeid L M; Linardic C M; Karolak L A; Hannun Y A
Programmed cell death induced by ceramide.
Science (New York, N.Y.) 1993;259(5102):1769-71.
1993: Khan W A; Blobe G; Halpern A; Taylor W; Wetsel W C; Burns D; Loomis C; Hannun Y A
Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.
The Journal of biological chemistry 1993;268(7):5063-8.
1993: Karolak L; Chandra A; Khan W; Marks B; Petros W P; Peters W P; Greenberg C S; Hannun Y A
High-dose chemotherapy-induced platelet defect: inhibition of platelet signal transduction pathways.
Molecular pharmacology 1993;43(1):37-44.
1993: Tuominen R K; Werner M H; Ye H; McMillian M K; Hudson P M; Hannun Y A; Hong J S
Biphasic generation of diacylglycerol by angiotensin and phorbol ester in bovine adrenal chromaffin cells.
Biochemical and biophysical research communications 1993;190(1):181-5.
1993: Blobe G C; Sachs C W; Khan W A; Fabbro D; Stabel S; Wetsel W C; Obeid L M; Fine R L; Hannun Y A
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
The Journal of biological chemistry 1993;268(1):658-64.
1993: Dobrowsky R T; Hannun Y A
Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A.
Advances in lipid research 1993;25():91-104.
1993: Hannun Y A; Obeid L M; Wolff R A
The novel second messenger ceramide: identification, mechanism of action, and cellular activity.
Advances in lipid research 1993;25():43-64.
1993: Hannun Y A; Bell R M
The sphingomyelin cycle: a prototypic sphingolipid signaling pathway.
Advances in lipid research 1993;25():27-41.
1993: Merrill A H; Hannun Y A; Bell R M
Introduction: sphingolipids and their metabolites in cell regulation.
Advances in lipid research 1993;25():1-24.
1992: Setty B N; Werner M H; Hannun Y A; Stuart M J
15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate.
Blood 1992;80(11):2765-73.
1992: Chao R; Khan W; Hannun Y A
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
The Journal of biological chemistry 1992;267(33):23459-62.
1992: Obeid L M; Blobe G C; Karolak L A; Hannun Y A
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
The Journal of biological chemistry 1992;267(29):20804-10.
1992: Bielawska A; Linardic C M; Hannun Y A
Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.
The Journal of biological chemistry 1992;267(26):18493-7.
1992: Bielawska A; Linardic C M; Hannun Y A
Modulation of cell growth and differentiation by ceramide.
FEBS letters 1992;307(2):211-4.
1992: Pushkareva MYu; Khan W A; Alessenko A V; Sahyoun N; Hannun Y A
Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.
The Journal of biological chemistry 1992;267(21):15246-51.
1992: Linardic C M; Jayadev S; Hannun Y A
Brefeldin A promotes hydrolysis of sphingomyelin.
The Journal of biological chemistry 1992;267(21):14909-11.
1992: Wetsel W C; Khan W A; Merchenthaler I; Rivera H; Halpern A E; Phung H M; Negro-Vilar A; Hannun Y A
Tissue and cellular distribution of the extended family of protein kinase C isoenzymes.
The Journal of cell biology 1992;117(1):121-33.
1992: Werner M H; Bielawska A E; Hannun Y A
Multiphasic generation of diacylglycerol in thrombin-activated human platelets.
The Biochemical journal 1992;282 ( Pt 3)():815-20.
1992: Dobrowsky R T; Hannun Y A
Ceramide stimulates a cytosolic protein phosphatase.
The Journal of biological chemistry 1992;267(8):5048-51.
1992: Khan W A; Blobe G C; Hannun Y A
Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.
The Journal of biological chemistry 1992;267(6):3605-12.
1992: Alessenko A; Khan W A; Wetsel W C; Hannun Y A
Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration.
Biochemical and biophysical research communications 1992;182(3):1333-9.
1992: Werner M H; Bielawska A E; Hannun Y A
Quantitative analysis of diacylglycerol second messengers in human platelets: correlation with aggregation and secretion.
Molecular pharmacology 1992;41(2):382-6.
1992: Bell R; Burns D; Okazaki T; Hannun Y
Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways.
Advances in experimental medicine and biology 1992;318():275-84.
1991: Khan W; el Touny S; Hannun Y A
Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C.
FEBS letters 1991;292(1-2):98-102.
1991: McDonald O B; Hannun Y A; Reynolds C H; Sahyoun N
Activation of casein kinase II by sphingosine.
The Journal of biological chemistry 1991;266(32):21773-6.
1991: Khan W A; Mascarella S W; Lewin A H; Wyrick C D; Carroll F I; Hannun Y A
Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets.
The Biochemical journal 1991;278 ( Pt 2)():387-92.
1991: Werner M H; Hannun Y A
Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion.
Blood 1991;78(2):435-44.
1991: Werner M H; Senzel L; Bielawska A; Khan W; Hannun Y A
Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation.
Molecular pharmacology 1991;39(4):547-56.
1991: Dennis E A; Rhee S G; Billah M M; Hannun Y A
Role of phospholipase in generating lipid second messengers in signal transduction.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(7):2068-77.
1991: Kim M Y; Linardic C; Obeid L; Hannun Y
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
The Journal of biological chemistry 1991;266(1):484-9.
1991: Hannun Y A; Merrill A H; Bell R M
Use of sphingosine as inhibitor of protein kinase C.
Methods in enzymology 1991;201():316-28.
1990: Khan W A; Dobrowsky R; el Touny S; Hannun Y A
Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation.
Biochemical and biophysical research communications 1990;172(2):683-91.
1990: Okazaki T; Bielawska A; Bell R M; Hannun Y A
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
The Journal of biological chemistry 1990;265(26):15823-31.
1990: el Touny S; Khan W; Hannun Y
Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition.
The Journal of biological chemistry 1990;265(27):16437-43.
1990: Panella T J; Peters W; White J G; Hannun Y A; Greenberg C S
Platelets acquire a secretion defect after high-dose chemotherapy.
Cancer 1990;65(8):1711-6.
1990: Hannun Y; Vugrin D
Long-term survival in patients treated for testicular seminoma.
Journal of surgical oncology 1990;43(3):177-80.
1990: Hannun Y A; Bell R M
Rat brain protein kinase C. Kinetic analysis of substrate dependence, allosteric regulation, and autophosphorylation.
The Journal of biological chemistry 1990;265(5):2962-72.
1990: Obeid L M; Okazaki T; Karolak L A; Hannun Y A
Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells.
The Journal of biological chemistry 1990;265(4):2370-4.
1989: Hannun Y A; Bell R M
Regulation of protein kinase C by sphingosine and lysosphingolipids.
Clinica chimica acta; international journal of clinical chemistry 1989;185(3):333-45.
1989: Sane D C; Bielawska A; Greenberg C S; Hannun Y A
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets.
Biochemical and biophysical research communications 1989;165(2):708-14.
1989: Okazaki T; Bell R M; Hannun Y A
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation.
The Journal of biological chemistry 1989;264(32):19076-80.
1989: Conkling P R; Patton K L; Hannun Y A; Greenberg C S; Weinberg J B
Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding.
The Journal of biological chemistry 1989;264(31):18440-4.
1989: Hannun Y A; Foglesong R J; Bell R M
The adriamycin-iron(III) complex is a potent inhibitor of protein kinase C.
The Journal of biological chemistry 1989;264(17):9960-6.
1989: Merrill A H; Nimkar S; Menaldino D; Hannun Y A; Loomis C; Bell R M; Tyagi S R; Lambeth J D; Stevens V L; Hunter R
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Biochemistry 1989;28(8):3138-45.
1989: Hannun Y A; Bell R M
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation.
Science (New York, N.Y.) 1989;243(4890):500-7.
1988: Hannun Y A; Bell R M
Aminoacridines, potent inhibitors of protein kinase C.
The Journal of biological chemistry 1988;263(11):5124-31.
1988: Faucher M; Gironès N; Hannun Y A; Bell R M; Davis R J
Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
The Journal of biological chemistry 1988;263(11):5319-27.
1988: Bell R M; Loomis C R; Hannun Y A
Protein kinase C regulation by sphingosine/lysosphingolipids.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():103-10.
1987: Hannun Y A; Greenberg C S; Bell R M
Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.
The Journal of biological chemistry 1987;262(28):13620-6.
1987: Hannun Y A; Bell R M
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses.
Science (New York, N.Y.) 1987;235(4789):670-4.
1987: Hannun Y A; Bell R M
Mechanism of activation of protein kinase C: role of diacylglycerol and calcium second messengers.
Society of General Physiologists series 1987;42():229-40.
1987: Hannun Y A; Bell R M
Mixed micellar assay for phorbol ester binding.
Methods in enzymology 1987;141():287-93.
1986: Merrill A H; Sereni A M; Stevens V L; Hannun Y A; Bell R M; Kinkade J M
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.
The Journal of biological chemistry 1986;261(27):12610-5.
1986: Hannun Y A; Loomis C R; Merrill A H; Bell R M
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.
The Journal of biological chemistry 1986;261(27):12604-9.
1986: Hannun Y A; Bell R M
Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.
The Journal of biological chemistry 1986;261(20):9341-7.
1986: Hannun Y A; Loomis C R; Bell R M
Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.
The Journal of biological chemistry 1986;261(16):7184-90.
1986: Ganong B R; Loomis C R; Hannun Y A; Bell R M
Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(5):1184-8.
1986: Bell R M; Hannun Y; Loomis C
Mixed micelle assay of protein kinase C.
Methods in enzymology 1986;124():353-9.
1986: Bell R M; Hannun Y A; Loomis C R
Mechanism of regulation of protein kinase C by lipid second messengers.
Symposium on Fundamental Cancer Research 1986;39():145-56.
1985: Hannun Y A; Loomis C R; Bell R M
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.
The Journal of biological chemistry 1985;260(18):10039-43.

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