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Lusong Luo

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Hong Zhao; Anthony Choudry; Dennis Dominguez; Osnat Herzberg; John A Latham; Kap Lim; Lusong Luo; Manish C Pathak; Debra Dunaway-Mariano
Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Melissa B Pappalardi; Dean E McNulty; John D Martin; Kelly E Fisher; Yong Jiang; Matthew C Burns; Huizhen Zhao; Thau Ho; Sharon Sweitzer; Benjamin Schwartz; Roland S Annan; Robert A Copeland; Peter J Tummino; Lusong Luo
Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.
Glenn S Van Aller; Jeff D Carson; Wei Tang; Hao Peng; Lin Zhao; Robert A Copeland; Peter J Tummino; Lusong Luo
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor.

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2012: Hong Zhao; Anthony Choudry; Dennis Dominguez; Osnat Herzberg; John A Latham; Kap Lim; Lusong Luo; Manish C Pathak; Debra Dunaway-Mariano
Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.
Biochemistry 2012;51(33):6490-2.
2011: Melissa B Pappalardi; Dean E McNulty; John D Martin; Kelly E Fisher; Yong Jiang; Matthew C Burns; Huizhen Zhao; Thau Ho; Sharon Sweitzer; Benjamin Schwartz; Roland S Annan; Robert A Copeland; Peter J Tummino; Lusong Luo
Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.
The Biochemical journal 2011;436(2):363-9.
2011: Glenn S Van Aller; Jeff D Carson; Wei Tang; Hao Peng; Lin Zhao; Robert A Copeland; Peter J Tummino; Lusong Luo
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor.
Biochemical and biophysical research communications 2011;406(2):194-9.
2008: Glenn S Van Aller; Jeff D Carson; Christine Fernandes; Ruth Lehr; Robert H Sinnamon; Robert B Kirkpatrick; Peter J Tummino; Lusong Luo
Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay.
Analytical biochemistry 2008;383(2):311-5.
2008: Melissa B Pappalardi; John D Martin; Yong Jiang; Matthew C Burns; Huizhen Zhao; Thau Ho; Sharon Sweitzer; Leng Lor; Benjamin Schwartz; Kevin Duffy; Richard Gontarek; Peter J Tummino; Robert Copeland; Lusong Luo
Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.
Biochemistry 2008;47(43):11165-7.
2008: Lusong Luo; Jeffrey D Carson; Kathleen S Molnar; Steven J Tuske; Stephen J Coales; Yoshitomo Hamuro; Chiu-mei Sung; Valery Sudakin; Kurt R Auger; Dashyant Dhanak; Jeffrey R Jackson; Pearl S Huang; Peter J Tummino; Robert A Copeland
Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.
Journal of the American Chemical Society 2008;130(24):7584-91.
2008: Latesh Lad; Lusong Luo; Jeffrey D Carson; Kenneth W Wood; James J Hartman; Robert Copeland; Roman Sakowicz
Mechanism of inhibition of human KSP by ispinesib.
Biochemistry 2008;47(11):3576-85.
2008: Jeffrey D Carson; Glenn S Van Aller; Ruth Lehr; Robert H Sinnamon; Robert B Kirkpatrick; Kurt R Auger; Dashyant Dhanak; Robert Copeland; Richard R Gontarek; Peter J Tummino; Lusong Luo
Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase.
The Biochemical journal 2008;409(2):519-24.
2008: Lata T Gooljarsingh; Ami S Lakdawala; Frank Coppo; Lusong Luo; Gregg Fields; Peter J Tummino; Richard R Gontarek
Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.
Protein science : a publication of the Protein Society 2008;17(1):66-71.
2007: Lusong Luo; Cynthia A Parrish; Neysa Nevins; Dean E McNulty; Amita M Chaudhari; Jeffrey D Carson; Valery Sudakin; Antony N Shaw; Ruth Lehr; Huizhen Zhao; Sharon Sweitzer; Latesh Lad; Kenneth W Wood; Roman Sakowicz; Roland S Annan; Pearl S Huang; Jeffrey R Jackson; Dashyant Dhanak; Robert Copeland; Kurt R Auger
ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.
Nature chemical biology 2007;3(11):722-6.
2007: Cynthia A Parrish; Nicholas D Adams; Kurt R Auger; Joelle L Burgess; Jeffrey D Carson; Amita M Chaudhari; Robert Copeland; Melody A Diamond; Carla A Donatelli; Kevin J Duffy; Leo F Faucette; Jeffrey T Finer; William F Huffman; Erin D Hugger; Jeffrey R Jackson; Steven D Knight; Lusong Luo; Michael L Moore; Kenneth A Newlander; Lance H Ridgers; Roman Sakowicz; Antony N Shaw; Chiu-Mei M Sung; David Sutton; Kenneth W Wood; Shu-Yun Zhang; Michael N Zimmerman; Dashyant Dhanak
Novel ATP-competitive kinesin spindle protein inhibitors.
Journal of medicinal chemistry 2007;50(20):4939-52.
2006: Alastair J King; Denis R Patrick; Roberta S Batorsky; Maureen L Ho; Hieu T Do; Shu Yun Zhang; Rakesh Kumar; David W Rusnak; Andrew K Takle; David M Wilson; Erin Hugger; Lifu Wang; Florian Karreth; Julie C Lougheed; Jae Lee; David Chau; Thomas Stout; Earl W May; Cynthia M Rominger; Michael D Schaber; Lusong Luo; Ami S Lakdawala; Jerry L Adams; Rooha Contractor; Keiran Smalley; Meenhard Herlyn; Michael M Morrissey; David A Tuveson; Pearl S Huang
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer research 2006;66(23):11100-5.
2006: Lusong Luo; Melissa B Pappalardi; Peter J Tummino; Robert Copeland; Marie E Fraser; Piotr K Grzyska; Robert P Hausinger
An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation.
Analytical biochemistry 2006;353(1):69-74.
2005: Robert Copeland; Lusong Luo; Kurt R Auger; Pearl S Huang
A method for determining intracellular concentrations of enzyme substrates from a combination of competitive inhibition and mutagenesis studies.
Analytical biochemistry 2005;337(2):351-3.
2004: Lusong Luo; Jeffrey D Carson; Dashyant Dhanak; Jeffrey R Jackson; Pearl S Huang; Yan Lee; Roman Sakowicz; Robert Copeland
Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.
Biochemistry 2004;43(48):15258-66.
2003: Jian Dong; Xuefeng Lu; Yansheng Wei; Lusong Luo; Debra Dunaway-Mariano; Paul R Carey
The strength of dehalogenase-substrate hydrogen bonding correlates with the rate of Meisenheimer intermediate formation.
Biochemistry 2003;42(31):9482-90.
2002: Lusong Luo; Rahul Kohli; Megumi Onishi; Uwe Linne; Mohamed A Marahiel; Christopher T Walsh
Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.
Biochemistry 2002;41(29):9184-96.
2002: Jian Dong; Paul R Carey; Yansheng Wei; Lusong Luo; Xuefeng Lu; Rui-Qin Liu; Debra Dunaway-Mariano
Raman evidence for Meisenheimer complex formation in the hydrolysis reactions of 4-fluorobenzoyl- and 4-nitrobenzoyl-coenzyme A catalyzed by 4-chlorobenzoyl-coenzyme A dehalogenase.
Biochemistry 2002;41(23):7453-63.
2002: Deborah Ann Miller; Lusong Luo; Nathan J Hillson; Thomas A Keating; Christopher T Walsh
Yersiniabactin synthetase: a four-protein assembly line producing the nonribosomal peptide/polyketide hybrid siderophore of Yersinia pestis.
Chemistry & biology 2002;9(3):333-44.
2002: Andrzej Lewandowicz; Juliusz Rudzinski; Lusong Luo; Debra Dunaway-Mariano; Piotr Paneth
Determination of the chlorine kinetic isotope effect on the 4-chlorobenzoyl-CoA dehalogenase-catalyzed nucleophilic aromatic substitution.
Archives of biochemistry and biophysics 2002;398(2):249-52.
2001: Lusong Luo; Kimberly Taylor; H Xiang; Yansheng Wei; Wenhai Zhang; Debra Dunaway-Mariano
Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis.
Biochemistry 2001;40(51):15684-92.
2001: Lusong Luo; Michael D Burkart; T Stachelhaus; Christopher T Walsh
Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase.
Journal of the American Chemical Society 2001;123(45):11208-18.
2001: Wenhai Zhang; Yansheng Wei; Lusong Luo; Kimberly Taylor; G Yang; Debra Dunaway-Mariano; Matthew M Benning; Hazel M Holden
Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis.
Biochemistry 2001;40(45):13474-82.
2001: Christopher T Walsh; Huawei Chen; Thomas A Keating; Brian K Hubbard; Heather C Losey; Lusong Luo; C Gary Marshall; Deborah Ann Miller; Hiten M Patel
Tailoring enzymes that modify nonribosomal peptides during and after chain elongation on NRPS assembly lines.
Current opinion in chemical biology 2001;5(5):525-34.
2001: Deborah Ann Miller; Christopher T Walsh; Lusong Luo
C-methyltransferase and cyclization domain activity at the intraprotein PK/NRP switch point of yersiniabactin synthetase.
Journal of the American Chemical Society 2001;123(34):8434-5.
2001: Lusong Luo; Christopher T Walsh
Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase.
Biochemistry 2001;40(18):5329-37.
1999: H Xiang; Lusong Luo; Kimberly Taylor; Debra Dunaway-Mariano
Interchange of catalytic activity within the 2-enoyl-coenzyme A hydratase/isomerase superfamily based on a common active site template.
Biochemistry 1999;38(24):7638-52.
1999: Jian Dong; H Xiang; Lusong Luo; Debra Dunaway-Mariano; Paul R Carey
Modulating electron density in the bound product, 4-hydroxybenzoyl-CoA, by mutations in 4-chlorobenzoyl-CoA dehalogenase near the 4-hydroxy group.
Biochemistry 1999;38(13):4198-206.