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Yong-Mei Zhang

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TOP 3
Matthew Garcia; Roberta Leonardi; Jerold E Rehg; Yong-Mei Zhang; Suzanne Jackowski
Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.
Roberta Leonardi; Yong-Mei Zhang; Mi-Kyung Yun; Ruobing Zhou; Fu-Yue Zeng; Wenwei Lin; Jimmy Cui; Taosheng Chen; Charles O Rock; Stephen W White; Suzanne Jackowski
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.
Darcie J Miller; Yong-Mei Zhang; Chitra Subramanian; Charles O Rock; Stephen W White
Structural basis for the transcriptional regulation of membrane lipid homeostasis.

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All Publications

2012: Matthew Garcia; Roberta Leonardi; Jerold E Rehg; Yong-Mei Zhang; Suzanne Jackowski
Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.
PloS one 2012;7(7):e40871.
2010: Roberta Leonardi; Yong-Mei Zhang; Mi-Kyung Yun; Ruobing Zhou; Fu-Yue Zeng; Wenwei Lin; Jimmy Cui; Taosheng Chen; Charles O Rock; Stephen W White; Suzanne Jackowski
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.
Chemistry & biology 2010;17(8):892-902.
2010: Darcie J Miller; Yong-Mei Zhang; Chitra Subramanian; Charles O Rock; Stephen W White
Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nature structural & molecular biology 2010;17(8):971-5.
2010: Chitra Subramanian; Charles O Rock; Yong-Mei Zhang
DesT coordinates the expression of anaerobic and aerobic pathways for unsaturated fatty acid biosynthesis in Pseudomonas aeruginosa.
Journal of bacteriology 2010;192(1):280-5.
2009: Kun Zhu; Yong-Mei Zhang; Charles O Rock
Transcriptional regulation of membrane lipid homeostasis in Escherichia coli.
The Journal of biological chemistry 2009;284(50):34880-8.
2009: Yong-Mei Zhang; Charles O Rock
Transcriptional regulation in bacterial membrane lipid synthesis.
Journal of lipid research 2009;50 Suppl():S115-9.
2009: Bai-Nan Wu; Yong-Mei Zhang; Charles O Rock; Jie J Zheng
Structural modification of acyl carrier protein by butyryl group.
Protein science : a publication of the Protein Society 2009;18(1):240-6.
2008: Yong-Mei Zhang; Matthew W Frank; Kun Zhu; Anand Mayasundari; Charles O Rock
PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.
The Journal of biological chemistry 2008;283(43):28788-94.
2008: Yong-Mei Zhang; Charles O Rock
Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis.
Journal of lipid research 2008;49(9):1867-74.
2008: Yong-Mei Zhang; Charles O Rock
Membrane lipid homeostasis in bacteria.
Nature reviews. Microbiology 2008;6(3):222-33.
2007: Yong-Mei Zhang; Kun Zhu; Matthew W Frank; Charles O Rock
A Pseudomonas aeruginosa transcription factor that senses fatty acid structure.
Molecular microbiology 2007;66(3):622-32.
2007: Roberta Leonardi; Yong-Mei Zhang; Athanasios Lykidis; Charles O Rock; Suzanne Jackowski
Localization and regulation of mouse pantothenate kinase 2.
FEBS letters 2007;581(24):4639-44.
2007: Bum Soo Hong; Guillermo Senisterra; Wael M Rabeh; Masoud Vedadi; Roberta Leonardi; Yong-Mei Zhang; Charles O Rock; Suzanne Jackowski; Hee-Won Park
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
The Journal of biological chemistry 2007;282(38):27984-93.
2007: Yong-Mei Zhang; Shigeru Chohnan; Kristopher G Virga; Robert D Stevens; Olga Ilkayeva; Brett R Wenner; James R Bain; Christopher B Newgard; Richard E Lee; Charles O Rock; Suzanne Jackowski
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
Chemistry & biology 2007;14(3):291-302.
2007: Roberta Leonardi; Charles O Rock; Suzanne Jackowski; Yong-Mei Zhang
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1494-9.
2006: Ying-Jie Lu; Yong-Mei Zhang; Kimberly D Grimes; Jianjun Qi; Richard E Lee; Charles O Rock
Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.
Molecular cell 2006;23(5):765-72.
2006: Bum Soo Hong; Mi Kyung Yun; Yong-Mei Zhang; Shigeru Chohnan; Charles O Rock; Stephen W White; Suzanne Jackowski; Hee-Won Park; Roberta Leonardi
Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties.
Structure (London, England : 1993) 2006;14(8):1251-61.
2006: Yong-Mei Zhang; Stephen W White; Charles O Rock
Inhibiting bacterial fatty acid synthesis.
The Journal of biological chemistry 2006;281(26):17541-4.
2006: Darcie J Miller; Yong-Mei Zhang; Charles O Rock; Stephen W White
Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa.
The Journal of biological chemistry 2006;281(26):18025-32.
2006: Harry S Courtney; Yong-Mei Zhang; Matthew W Frank; Charles O Rock
Serum opacity factor, a streptococcal virulence factor that binds to apolipoproteins A-I and A-II and disrupts high density lipoprotein structure.
The Journal of biological chemistry 2006;281(9):5515-21.
2006: Kristopher G Virga; Yong-Mei Zhang; Roberta Leonardi; Robert A Ivey; Kirk Edward Hevener; Hee-Won Park; Suzanne Jackowski; Charles O Rock; Richard E Lee
Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.
Bioorganic & medicinal chemistry 2006;14(4):1007-20.
2006: Pilho Kim; Yong-Mei Zhang; Gautham Shenoy; Quynh Anh Nguyen; Helena I Boshoff; Ujjini H Manjunatha; Michael B Goodwin; John Lonsdale; Allen C Price; Darcie J Miller; Ken Duncan; Stephen W White; Charles O Rock; Clifton E Barry; Cynthia S Dowd
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Journal of medicinal chemistry 2006;49(1):159-71.
2006: Yong-Mei Zhang; Charles O Rock; Suzanne Jackowski
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration.
The Journal of biological chemistry 2006;281(1):107-14.
2005: Yong-Mei Zhang; Charles O Rock; Suzanne Jackowski
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.
The Journal of biological chemistry 2005;280(38):32594-601.
2005: Edgar M Harvat; Yong-Mei Zhang; Can V Tran; Zhongge Zhang; Matthew W Frank; Charles O Rock; Milton H Saier
Lysophospholipid flipping across the Escherichia coli inner membrane catalyzed by a transporter (LplT) belonging to the major facilitator superfamily.
The Journal of biological chemistry 2005;280(12):12028-34.
2005: Roberta Leonardi; Yong-Mei Zhang; Charles O Rock; Suzanne Jackowski
Coenzyme A: back in action.
Progress in lipid research 2005;44(2-3):125-53.
2005: Roberta Leonardi; Shigeru Chohnan; Yong-Mei Zhang; Kristopher G Virga; Richard E Lee; Charles O Rock; Suzanne Jackowski
A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.
The Journal of biological chemistry 2005;280(5):3314-22.
2005: Stephen W White; Jie Zheng; Yong-Mei Zhang
The structural biology of type II fatty acid biosynthesis.
Annual review of biochemistry 2005;74():791-831.
2004: Yong-Mei Zhang; Matthew W Frank; Kristopher G Virga; Richard E Lee; Charles O Rock; Suzanne Jackowski
Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.
The Journal of biological chemistry 2004;279(49):50969-75.
2004: Yong-Mei Zhang; Ying-Jie Lu; Charles O Rock
The reductase steps of the type II fatty acid synthase as antimicrobial targets.
Lipids 2004;39(11):1055-60.
2004: Robert A Ivey; Yong-Mei Zhang; Kristopher G Virga; Kirk Edward Hevener; Richard E Lee; Charles O Rock; Suzanne Jackowski; Hee-Won Park
The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
The Journal of biological chemistry 2004;279(34):35622-9.
2004: Yong-Mei Zhang; Charles O Rock
Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase.
The Journal of biological chemistry 2004;279(30):30994-1001.
2004: Suzanne Jackowski; Jerold E Rehg; Yong-Mei Zhang; Jina Wang; Karen Miller; Pam Jackson; Mohammad A Karim
Disruption of CCTbeta2 expression leads to gonadal dysfunction.
Molecular and cellular biology 2004;24(11):4720-33.
2004: Allen C Price; Yong-Mei Zhang; Charles O Rock; Stephen W White
Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.
Structure (London, England : 1993) 2004;12(3):417-28.
2004: Ying-Jie Lu; Yong-Mei Zhang; Charles O Rock
Product diversity and regulation of type II fatty acid synthases.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2004;82(1):145-55.
2003: Yong-Mei Zhang; Bainan Wu; Jie Zheng; Charles O Rock
Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction.
The Journal of biological chemistry 2003;278(52):52935-43.
2003: Mikyung Yun; Lakhu Keshvara; Cheon-Gil Park; Yong-Mei Zhang; J Bradley Dickerson; Jie Zheng; Charles O Rock; Tom Curran; Hee-Won Park
Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
The Journal of biological chemistry 2003;278(38):36572-81.
2002: Charles O Rock; Mohammad A Karim; Yong-Mei Zhang; Suzanne Jackowski
The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes.
Gene 2002;291(1-2):35-43.
2002: Hing C Wong; Gaohua Liu; Yong-Mei Zhang; Charles O Rock; Jie Zheng
The solution structure of acyl carrier protein from Mycobacterium tuberculosis.
The Journal of biological chemistry 2002;277(18):15874-80.
2002: Suzanne Jackowski; Yong-Mei Zhang; Allen C Price; Stephen W White; Charles O Rock
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.
Antimicrobial agents and chemotherapy 2002;46(5):1246-52.
2001: Allen C Price; Yong-Mei Zhang; Charles O Rock; Stephen W White
Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis.
Biochemistry 2001;40(43):12772-81.
2001: Yong-Mei Zhang; M S Rao; RJ Heath; Allen C Price; A J Olson; Charles O Rock; Stephen W White
Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.
The Journal of biological chemistry 2001;276(11):8231-8.