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Patrik Brundin

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Sonia George; Nicole Reichenbach; Nolwen L Rey; Jennifer A Steiner; Patrik Brundin
α-Synuclein: the long distance runner.
Carla M Lema Tomé; Nolwen L Rey; Trevor Tyson; Markus Britschgi; Stefan Grathwohl; Patrik Brundin
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?
Awahan Rahman; Yulia Shakirova; Kristina E Andersson; Patrik Brundin; Mari Ekman; Jonas S Erjefält; Jia-Yi Li; Matthias Mörgelin; Karl Swärd
Late onset vascular dysfunction in the R6/1 model of Huntington's disease.

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All Publications

2013: Sonia George; Nicole Reichenbach; Nolwen L Rey; Jennifer A Steiner; Patrik Brundin
α-Synuclein: the long distance runner.
Brain pathology (Zurich, Switzerland) 2013;23(3):350-7.
2013: Carla M Lema Tomé; Nolwen L Rey; Trevor Tyson; Markus Britschgi; Stefan Grathwohl; Patrik Brundin
Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?
Molecular neurobiology 2013;47(2):561-74.
2013: Awahan Rahman; Yulia Shakirova; Kristina E Andersson; Patrik Brundin; Mari Ekman; Jonas S Erjefält; Jia-Yi Li; Matthias Mörgelin; Karl Swärd
Late onset vascular dysfunction in the R6/1 model of Huntington's disease.
European journal of pharmacology 2013;698(1-3):345-53.
2013: Géraldine H Petit; Elijahu Berkovich; Cheryl Fitzer-Attas; Karina Fog; Mark Hickery; Pekka Kallunki; Patrik Brundin
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.
PloS one 2013;8(4):e60691.
2013: Christopher J R Dunning; Sonia George; Patrik Brundin
What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
Prion 2013;7(1):92-7.
2012: Candan Depboylu; Patrik Brundin; Matthias Höllerhage; Wolfgang H Oertel; Stefan Schnurrbusch; André Schrattenholz; Günter U Höglinger
Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease.
Neuroscience letters 2012;531(2):209-14.
2012: Christopher J R Dunning; Juan F Reyes; Jennifer A Steiner; Patrik Brundin
Can Parkinson's disease pathology be propagated from one neuron to another?
Progress in neurobiology 2012;97(2):205-19.
2012: Patrik Brundin; Jeffrey H Kordower
Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy.
Progress in brain research 2012;200():221-41.
2012: Elodie Angot; Anders Björklund; Peter Ekström; Carla M Lema Tomé; Bengt Mattsson; Jennifer A Steiner; Patrik Brundin
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo.
PloS one 2012;7(6):e39465.
2012: Gesine Paul; Thomas Reinbothe; Erik Renström; Laurent Roybon; Mikael Svensson; Edward Visse; Ilknur Özen; Nicolaj S Christophersen; Karin Dannaeus; Anders Haegerstrand; Catarina Henriques-Oliveira; Katarina Jansson; Sergey V Anisimov; Johan Bengzon; Patrik Brundin
The adult human brain harbors multipotent perivascular mesenchymal stem cells.
PloS one 2012;7(4):e35577.
2011: José L Venero; Patrik Brundin; M A Burguillos; B Joseph
The executioners sing a new song: killer caspases activate microglia.
Cell death and differentiation 2011;18(11):1679-91.
2011: Ana I Duarte; J-Y Li; Catarina R Oliveira; G H Petit; S Ranganathan; M Björkqvist; Patrik Brundin; A Cristina Rego
IGF-1 protects against diabetic features in an in vivo model of Huntington's disease.
Experimental neurology 2011;231(2):314-9.
2011: Jorien M M van der Burg; Annika Winqvist; N Ahmad Aziz; Gillian P Bates; Maria Björkqvist; Patrik Brundin; Marion L C Maat-Schieman; Raymund A C Roos; Nils Wierup
Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.
Neurobiology of disease 2011;44(1):1-8.
2011: J A Steiner; E Angot; Patrik Brundin
A deadly spread: cellular mechanisms of α-synuclein transfer.
Cell death and differentiation 2011;18(9):1425-33.
2011: Philip Gaughwin; Bing Lim; Henry Yang; Maciej Ciesla; Patrik Brundin
Stage-specific modulation of cortical neuronal development by Mmu-miR-134.
Cerebral cortex (New York, N.Y. : 1991) 2011;21(8):1857-69.
2011: Patrik Brundin; Roger Olsson
Can α-synuclein be targeted in novel therapies for Parkinson's disease?
Expert review of neurotherapeutics 2011;11(7):917-9.
2011: Thomas Carlsson; Friederike R Schindler; Matthias Höllerhage; Candan Depboylu; Oscar Arias-Carrión; Stefan Schnurrbusch; Thomas W Rösler; Wojciech Wozny; Gerhard P Schwall; Karlfried Groebe; Wolfgang H Oertel; Patrik Brundin; André Schrattenholz; Günter U Höglinger
Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's disease.
Journal of neurochemistry 2011;117(6):1066-74.
2011: Philip Michael Gaughwin; Maciej Ciesla; Nayana Lahiri; Sarah J Tabrizi; Patrik Brundin; Maria Björkqvist
Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease.
Human molecular genetics 2011;20(11):2225-37.
2011: Miguel A Burguillos; Tomas Deierborg; Edel Kavanagh; Annette Persson; Nabil Hajji; Albert Garcia-Quintanilla; Josefina Cano; Patrik Brundin; Elisabet Englund; Jose L Venero; Bertrand Joseph
Caspase signalling controls microglia activation and neurotoxicity.
Nature 2011;472(7343):319-24.
2011: Sergey V Anisimov; Nicolaj S Christophersen; Ana S Correia; Vanessa J Hall; Ingrid Sandelin; Jia-Yi Li; Patrik Brundin
Identification of molecules derived from human fibroblast feeder cells that support the proliferation of human embryonic stem cells.
Cellular & molecular biology letters 2011;16(1):79-88.
2011: Karin van der Borght; Rickard Köhnke; Nathanael Göransson; Tomas Deierborg; Patrik Brundin; Charlotte Erlanson-Albertsson; Andreas Lindqvist
Reduced neurogenesis in the rat hippocampus following high fructose consumption.
Regulatory peptides 2011;167(1):26-30.
2011: Christian Hansen; Elodie Angot; Ann-Louise Bergström; Jennifer A Steiner; Laura Pieri; Gesine Paul; Tiago F Outeiro; Ronald Melki; Pekka Kallunki; Karina Fog; Jia-Yi Li; Patrik Brundin
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.
The Journal of clinical investigation 2011;121(2):715-25.
2011: V Fedele; Laurent Roybon; U Nordström; Jia-Yi Li; Patrik Brundin
Neurogenesis in the R6/2 mouse model of Huntington's disease is impaired at the level of NeuroD1.
Neuroscience 2011;173():76-81.
2010: T Deierborg; Laurent Roybon; A R Inacio; J Pesic; Patrik Brundin
Brain injury activates microglia that induce neural stem cell proliferation ex vivo and promote differentiation of neurosphere-derived cells into neurons and oligodendrocytes.
Neuroscience 2010;171(4):1386-96.
2010: Asuka Morizane; Vladimer Darsalia; Oktar Guloglu; Tord Hjalt; Manolo Carta; Jia-Yi Li; Patrik Brundin
A simple method for large-scale generation of dopamine neurons from human embryonic stem cells.
Journal of neuroscience research 2010;88(16):3467-78.
2010: Elodie Angot; Jennifer A Steiner; Christian Hansen; Jia-Yi Li; Patrik Brundin
Are synucleinopathies prion-like disorders?
Lancet neurology 2010;9(11):1128-38.
2010: Laura E Allan; Géraldine H Petit; Patrik Brundin
Cell transplantation in Parkinson's disease: problems and perspectives.
Current opinion in neurology 2010;23(4):426-32.
2010: Bruno Pereira Carreira; Maria Inês Morte; Angela Inácio; Gabriel Costa; Joana Rosmaninho-Salgado; Fabienne Agasse; Anália Carmo; Patrícia Couceiro; Patrik Brundin; António Francisco Ambrósio; Caetana Monteiro Carvalho; Inês Maria Araújo
Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor.
Stem cells (Dayton, Ohio) 2010;28(7):1219-30.
2010: Jia-Yi Li; Elisabet Englund; Håkan Widner; Stig Rehncrona; Anders Björklund; Olle Lindvall; Patrik Brundin
Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2010;25(8):1091-6.
2010: Laurent Roybon; Teresa L Mastracci; Diogo Ribeiro; Lori Sussel; Patrik Brundin; Jia-Yi Li
GABAergic differentiation induced by Mash1 is compromised by the bHLH proteins Neurogenin2, NeuroD1, and NeuroD2.
Cerebral cortex (New York, N.Y. : 1991) 2010;20(5):1234-44.
2010: Patrik Brundin; Ronald Melki; Ron Kopito
Prion-like transmission of protein aggregates in neurodegenerative diseases.
Nature reviews. Molecular cell biology 2010;11(4):301-7.
2010: Hyun-Seob Lee; Eun-Ji Bae; Sang-Hoon Yi; Jae-Won Shim; A-Young Jo; Jin-Sun Kang; Eun-Hye Yoon; Yong-Hee Rhee; Chang-Hwan Park; Hyun-Chul Koh; Hyun-Jung Kim; Hueng-Sik Choi; Jeung-Whan Han; Yong-Sung Lee; Jaesang Kim; Jia-Yi Li; Patrik Brundin; Hyun-Seob Lee
Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival.
Stem cells (Dayton, Ohio) 2010;28(3):501-12.
2010: Patrik Brundin; Roger A Barker; Malin Parmar
Neural grafting in Parkinson's disease Problems and possibilities.
Progress in brain research 2010;184():265-94.
2010: Philipp B Kuegler; Bastian Zimmer; Tanja Waldmann; Birte Baudis; Sten Ilmjärv; Jürgen Hescheler; Phil Gaughwin; Patrik Brundin; William Mundy; Anna K Bal-Price; André Schrattenholz; Karl-Heinz Krause; Christoph van Thriel; Mahendra S Rao; Suzanne Kadereit; Marcel Leist
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing.
ALTEX 2010;27(1):17-42.
2009: Elodie Angot; Patrik Brundin
Dissecting the potential molecular mechanisms underlying alpha-synuclein cell-to-cell transfer in Parkinson's disease.
Parkinsonism & related disorders 2009;15 Suppl 3():S143-7.
2009: Jeffrey Kordower; Patrik Brundin
Propagation of host disease to grafted neurons: accumulating evidence.
Experimental neurology 2009;220(2):224-5.
2009: Ruben Smith; Karl Bacos; Valentina Fedele; Denis Soulet; Helena A Walz; Stefanie Obermüller; Anders Lindqvist; Maria Björkqvist; Pontus Klein; Patrik Onnerfjord; Patrik Brundin; Hindrik Mulder; Jia-Yi Li
Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.
Human molecular genetics 2009;18(20):3942-54.
2009: Tomas Deierborg; Karin Staflin; Jelena Pesic; Laurent Roybon; Patrik Brundin; Cecilia Lundberg
Absence of striatal newborn neurons with mature phenotype following defined striatal and cortical excitotoxic brain injuries.
Experimental neurology 2009;219(1):363-7.
2009: E L Lane; L Vercammen; M A Cenci; Patrik Brundin
Priming for L-DOPA-induced abnormal involuntary movements increases the severity of amphetamine-induced dyskinesia in grafted rats.
Experimental neurology 2009;219(1):355-8.
2009: Christa J Maynard; Claudia Böttcher; Zaira Ortega; Ruben Smith; Bogdan I Florea; Miguel Díaz-Hernández; Patrik Brundin; Hermen S Overkleeft; Jia-Yi Li; Jose J Lucas; Nico P Dantuma
Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13986-91.
2009: Jorien M M van der Burg; Maria Björkqvist; Patrik Brundin
Beyond the brain: widespread pathology in Huntington's disease.
Lancet neurology 2009;8(8):765-74.
2009: Emma Louise Lane; Patrik Brundin; M Angela Cenci
Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease.
Neurobiology of disease 2009;35(1):42-51.
2009: Ali Khoshnan; Jan Ko; Simona Tescu; Patrik Brundin; Paul H Patterson
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
PloS one 2009;4(6):e5768.
2009: Laurent Roybon; Tord Hjalt; Simon Stott; Francois Guillemot; Jia-Yi Li; Patrik Brundin
Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis.
PloS one 2009;4(3):e4779.
2009: Laurent Roybon; Tomas Deierborg; Patrik Brundin; Jia-Yi Li
Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis.
The European journal of neuroscience 2009;29(2):232-43.
2009: Jeffrey Kordower; Patrik Brundin
Lewy body pathology in long-term fetal nigral transplants: is Parkinson's disease transmitted from one neural system to another?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(1):254.
2008: Timothy M Fountaine; Lara Lourenco Venda; Nicholas Warrick; Helen C Christian; Patrik Brundin; Keith M Channon; Richard Wade-Martins
The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons.
The European journal of neuroscience 2008;28(12):2459-73.
2008: N A Aziz; J M M van der Burg; G B Landwehrmeyer; Patrik Brundin; Theo Stijnen; Raymund A C Roos
Weight loss in Huntington disease increases with higher CAG repeat number.
Neurology 2008;71(19):1506-13.
2008: E L Lane; D Soulet; L Vercammen; M Angela Cenci; Patrik Brundin
Neuroinflammation in the generation of post-transplantation dyskinesia in Parkinson's disease.
Neurobiology of disease 2008;32(2):220-8.
2008: Patrik Brundin; Jia-Yi Li; Janice L Holton; Olle Lindvall; Tamas Revesz
Research in motion: the enigma of Parkinson's disease pathology spread.
Nature reviews. Neuroscience 2008;9(10):741-5.
2008: Maria Björkqvist; Edward J Wild; Jenny Thiele; Aurelio Silvestroni; Ralph Andre; Nayana Lahiri; Elsa Raibon; Richard V Lee; Caroline L Benn; Denis Soulet; Anna Magnusson; Ben Woodman; Christian Landles; Mahmoud A Pouladi; Michael R Hayden; Azadeh Khalili-Shirazi; Mark W Lowdell; Patrik Brundin; Gillian P Bates; Blair R Leavitt; Thomas Möller; Sarah J Tabrizi
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
The Journal of experimental medicine 2008;205(8):1869-77.
2008: Tomas Deierborg; Denis Soulet; Laurent Roybon; Vanessa Hall; Patrik Brundin
Emerging restorative treatments for Parkinson's disease.
Progress in neurobiology 2008;85(4):407-32.
2008: Ana Sofia Correia; Sergey V Anisimov; Jia-Yi Li; Patrik Brundin
Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20.
Frontiers in neuroscience 2008;2(1):26-34.
2008: Nigel I Wood; Anna O G Goodman; Jorien M M van der Burg; Véronique Gazeau; Patrik Brundin; Maria Björkqvist; Asa Petersén; Sarah J Tabrizi; Roger A Barker; A Jennifer Morton
Increased thirst and drinking in Huntington's disease and the R6/2 mouse.
Brain research bulletin 2008;76(1-2):70-9.
2008: Jia-Yi Li; Elisabet Englund; Janice L Holton; Denis Soulet; Peter Hagell; Andrew J Lees; Tammaryn Lashley; Niall Quinn; Stig Rehncrona; Anders Björklund; Håkan Widner; Tamas Revesz; Olle Lindvall; Patrik Brundin
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Nature medicine 2008;14(5):501-3.
2008: Karl Bacos; Maria Björkqvist; Asa Petersén; Lena Luts; Marion L C Maat-Schieman; Raymund A C Roos; Frank Sundler; Patrik Brundin; Hindrik Mulder; Nils Wierup
Islet beta-cell area and hormone expression are unaltered in Huntington's disease.
Histochemistry and cell biology 2008;129(5):623-9.
2008: Inês M Araújo; Joana M A C Gil; Bruno P Carreira; Paul Mohapel; Asa Petersen; Paulo S Pinheiro; Denis Soulet; Ben A Bahr; Patrik Brundin; Caetana M Carvalho
Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus.
Journal of neurochemistry 2008;105(3):666-76.
2008: Laurent Roybon; Tord Hjalt; Nicolaj S Christophersen; Jia-Yi Li; Patrik Brundin
Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(14):3644-56.
2008: Jia-Yi Li; Nicolaj S Christophersen; Vanessa J Hall; Denis Soulet; Patrik Brundin
Critical issues of clinical human embryonic stem cell therapy for brain repair.
Trends in neurosciences 2008;31(3):146-53.
2008: Thole Zuchner; Patrik Brundin
Mutant huntingtin can paradoxically protect neurons from death.
Cell death and differentiation 2008;15(3):435-42.
2008: Marcel Leist; Susanne Bremer; Patrik Brundin; Juergen Hescheler; Agnete Kirkeby; Karl-Heinz Krause; Peter Poerzgen; Michel Puceat; Mathias Schmidt; André Schrattenholz; Naomi B Zak; Hannes Hentze
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy.
ALTEX 2008;25(3):163-90.
2008: Asuka Morizane; Jia-Yi Li; Patrik Brundin
From bench to bed: the potential of stem cells for the treatment of Parkinson's disease.
Cell and tissue research 2008;331(1):323-36.
2008: Jorien M M van der Burg; Karl Bacos; Nigel I Wood; Andreas Lindqvist; Nils Wierup; Ben Woodman; Jaclyn I Wamsteeker; Ruben Smith; Tomas Deierborg; Michael J Kuhar; Gillian P Bates; Hindrik Mulder; Charlotte Erlanson-Albertsson; A Jennifer Morton; Patrik Brundin; Asa Petersén; Maria Björkqvist
Increased metabolism in the R6/2 mouse model of Huntington's disease.
Neurobiology of disease 2008;29(1):41-51.
2007: Vanessa J Hall; Jia-Yi Li; Patrik Brundin
Restorative cell therapy for Parkinson's disease: a quest for the perfect cell.
Seminars in cell & developmental biology 2007;18(6):859-69.
2007: Maria Björkqvist; Blair R Leavitt; Jörgen E Nielsen; Bernhard Landwehrmeyer; Daniel Ecker; Hindrik Mulder; Patrik Brundin; Asa Petersén
Cocaine- and amphetamine-regulated transcript is increased in Huntington disease.
Movement disorders : official journal of the Movement Disorder Society 2007;22(13):1952-4.
2007: Ruben Smith; Pontus Klein; Yeliz Koc-Schmitz; Henry J Waldvogel; Richard L M Faull; Patrik Brundin; Markus Plomann; Jia-Yi Li
Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease.
Journal of neurochemistry 2007;103(1):115-23.
2007: Nicolaj S Christophersen; Mette Grønborg; Thomas N Petersen; Lone Fjord-Larsen; Jesper R Jørgensen; Bengt Juliusson; Nikolaj Blom; Carl Rosenblad; Patrik Brundin
Midbrain expression of Delta-like 1 homologue is regulated by GDNF and is associated with dopaminergic differentiation.
Experimental neurology 2007;204(2):791-801.
2007: Gesine Paul; Nicolaj S Christophersen; Heather Raymon; Caroline Kiaer; Ruben Smith; Patrik Brundin
Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line--studies in vitro and after intracerebral grafting in vivo.
Molecular and cellular neurosciences 2007;34(3):390-9.
2007: Karin van der Borght; Patrik Brundin
Reduced expression of PSA-NCAM in the hippocampus and piriform cortex of the R6/1 and R6/2 mouse models of Huntington's disease.
Experimental neurology 2007;204(1):473-8.
2007: Nicolaj Strøyer Christophersen; Patrik Brundin
Large stem cell grafts could lead to erroneous interpretations of behavioral results?
Nature medicine 2007;13(2):118; author reply 118-9.
2007: Ana Sofia Correia; Sergey V Anisimov; Laurent Roybon; Jia-Yi Li; Patrik Brundin
Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells.
Frontiers in neuroanatomy 2007;1():4.
2007: Jan Fahrenkrug; Natalija Popovic; Birgitte Georg; Patrik Brundin; Jens Hannibal
Decreased VIP and VPAC2 receptor expression in the biological clock of the R6/2 Huntington's disease mouse.
Journal of molecular neuroscience : MN 2007;31(2):139-48.
2007: Sergey V Anisimov; Nicolaj S Christophersen; Ana S Correia; Jia-Yi Li; Patrik Brundin
"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells.
BMC genomics 2007;8():46.
2006: A Lindqvist; Paul Mohapel; B Bouter; Helena Frielingsdorf; Donald P Pizzo; Patrik Brundin; Charlotte Erlanson-Albertsson
High-fat diet impairs hippocampal neurogenesis in male rats.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2006;13(12):1385-8.
2006: Josefine Nygren; Tadeusz Wieloch; Jelena Pesic; Patrik Brundin; Tomas Deierborg
Enriched environment attenuates cell genesis in subventricular zone after focal ischemia in mice and decreases migration of newborn cells to the striatum.
Stroke; a journal of cerebral circulation 2006;37(11):2824-9.
2006: Ruben Smith; Hinfan Chung; Sara Rundquist; Marion L C Maat-Schieman; Lesley Colgan; Elisabet Englund; Yong-Jian Liu; Raymund A C Roos; Richard L M Faull; Patrik Brundin; Jia-Yi Li
Cholinergic neuronal defect without cell loss in Huntington's disease.
Human molecular genetics 2006;15(21):3119-31.
2006: Paul Mohapel; K Mundt-Petersen; Patrik Brundin; Helena Frielingsdorf
Working memory training decreases hippocampal neurogenesis.
Neuroscience 2006;142(3):609-13.
2006: Nicolaj S Christophersen; Xia Meijer; Jesper R Jørgensen; Ulrica Englund; Mette Grønborg; Ake Seiger; Patrik Brundin; Lars U Wahlberg
Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain.
Brain research bulletin 2006;70(4-6):457-66.
2006: Jenny E Westin; Hanna S Lindgren; Jonathan Gardi; Jens R Nyengaard; Patrik Brundin; Paul Mohapel; M Angela Cenci
Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(37):9448-61.
2006: Patrik Brundin; M Angela Cenci; Tadeusz Wieloch
On the move to stimulate cell plasticity in the substantia nigra in Parkinson's disease.
Experimental neurology 2006;201(1):1-6.
2006: Maria Björkqvist; Asa Petersén; J Nielsen; D Ecker; Hindrik Mulder; Michael R Hayden; B Landwehrmeyer; Patrik Brundin; Blair R Leavitt
Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease.
Clinical genetics 2006;70(1):78-9.
2006: Anke Brederlau; Ana Sofia Correia; Sergey V Anisimov; Muna Elmi; Gesine Paul; Laurent Roybon; Asuka Morizane; Filip Bergquist; Ilse Riebe; Ulf Nannmark; Manolo Carta; Erik Hanse; Jun Takahashi; Yoshiki Sasai; Keiko Funa; Patrik Brundin; Peter S Eriksson; Jia-Yi Li
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation.
Stem cells (Dayton, Ohio) 2006;24(6):1433-40.
2006: Laurent Roybon; Zhi Ma; Fredrik Asztely; Anna Fosum; Sten Eirik W Jacobsen; Patrik Brundin; Jia-Yi Li
Failure of transdifferentiation of adult hematopoietic stem cells into neurons.
Stem cells (Dayton, Ohio) 2006;24(6):1594-604.
2006: Natalija Popovic; Patrik Brundin
Therapeutic potential of controlled drug delivery systems in neurodegenerative diseases.
International journal of pharmaceutics 2006;314(2):120-6.
2006: Maria Björkqvist; Asa Petersén; Karl Bacos; Jeremy Isaacs; Per Norlén; Joana Gil; Natalija Popovic; Frank Sundler; Gillian P Bates; Sarah J Tabrizi; Patrik Brundin; Hindrik Mulder
Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease.
Human molecular genetics 2006;15(10):1713-21.
2006: E L Lane; C Winkler; Patrik Brundin; M Angela Cenci
The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat.
Neurobiology of disease 2006;22(2):334-45.
2006: Gesine Paul; Young Hwan Ahn; Jia-Yi Li; Patrik Brundin
Transplantation in Parkinson's disease: The future looks bright.
Advances in experimental medicine and biology 2006;557():221-48.
2005: Zoe Puschban; Nadia Stefanova; Asa Petersén; Christian Winkler; Patrik Brundin; Werner Poewe; Gregor Wenning
Evidence for dopaminergic re-innervation by embryonic allografts in an optimized rat model of the Parkinsonian variant of multiple system atrophy.
Brain research bulletin 2005;68(1-2):54-8.
2005: Laurent Roybon; Patrik Brundin; Jia-Yi Li
Stromal cell-derived inducing activity does not promote dopaminergic differentiation, but enhances differentiation and proliferation of neural stem cell-derived astrocytes.
Experimental neurology 2005;196(2):373-80.
2005: Ruben Smith; Asa Petersén; Gillian P Bates; Patrik Brundin; Jia-Yi Li
Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction.
Neurobiology of disease 2005;20(3):673-84.
2005: Joana M A C Gil; Paul Mohapel; Inês M Araújo; Natalija Popovic; Jia-Yi Li; Patrik Brundin; Asa Petersén
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice.
Neurobiology of disease 2005;20(3):744-51.
2005: Eugenia Papalexi; Anna Persson; Maria Björkqvist; Asa Petersén; Ben Woodman; Gillian P Bates; Frank Sundler; Hindrik Mulder; Patrik Brundin; Natalija Popovic
Reduction of GnRH and infertility in the R6/2 mouse model of Huntington's disease.
The European journal of neuroscience 2005;22(6):1541-6.
2005: Ruben Smith; Patrik Brundin; Jia-Yi Li
Synaptic dysfunction in Huntington's disease: a new perspective.
Cellular and molecular life sciences : CMLS 2005;62(17):1901-12.
2005: Young-Hwan Ahn; Jean-Charles Bensadoun; Patrick Aebischer; Anne D Zurn; Ake Seiger; Anders Björklund; Olle Lindvall; Lars U Wahlberg; Patrik Brundin; Gabriele S Kaminski Schierle
Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor.
Brain research bulletin 2005;66(2):135-42.
2005: Julie Lotharius; Jeppe Falsig; Johan van Beek; Sarah Payne; Ralf Dringen; Patrik Brundin; Marcel Leist
Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(27):6329-42.
2005: Jia Yi Li; Natalija Popovic; Patrik Brundin
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(3):447-64.
2005: Ruxandra Iancu; Paul Mohapel; Patrik Brundin; Gesine Paul
Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice.
Behavioural brain research 2005;162(1):1-10.
2005: Natalija Popovic; Matthew Maingay; Deniz Kirik; Patrik Brundin
Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes.
Experimental neurology 2005;193(1):65-74.
2005: Inês M Araújo; Sara Xapelli; Joana M A C Gil; Paul Mohapel; Asa Petersén; Paulo S Pinheiro; João O Malva; Ben A Bahr; Patrik Brundin; Caetana M Carvalho
Proteolysis of NR2B by calpain in the hippocampus of epileptic rats.
Neuroreport 2005;16(4):393-6.
2005: Maria Björkqvist; Malin Fex; Erik Renström; Nils Wierup; Asa Petersén; Joana Gil; Karl Bacos; Natalija Popovic; Jia-Yi Li; Frank Sundler; Patrik Brundin; Hindrik Mulder
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis.
Human molecular genetics 2005;14(5):565-74.
2005: Lena Larsson Brundin; Patrik Brundin
[Not everything worked perfectly in Thailand].
Läkartidningen 2005;102(8):584; author reply 584.
2005: Ana Sofia Correia; Sergey V Anisimov; Jia-Yi Li; Patrik Brundin
Stem cell-based therapy for Parkinson's disease.
Annals of medicine 2005;37(7):487-98.
2005: Jenny Karlsson; Asa Petersén; Gunilla Gidö; Tadeusz Wieloch; Patrik Brundin
Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient.
Cell transplantation 2005;14(5):301-9.
2005: Paul Mohapel; Helena Frielingsdorf; J Häggblad; O Zachrisson; Patrik Brundin
Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions.
Neuroscience 2005;132(3):767-76.
2005: Asa Petersén; Joana Gil; Marion L C Maat-Schieman; Maria Björkqvist; Heikki Tanila; Inês M Araújo; Ruben Smith; Natalija Popovic; Nils Wierup; Per Norlén; Jia-Yi Li; Raymund A C Roos; Frank Sundler; Hindrik Mulder; Patrik Brundin
Orexin loss in Huntington's disease.
Human molecular genetics 2005;14(1):39-47.
2004: Laurent Roybon; Nicolaj S Christophersen; Patrik Brundin; Jia-Yi Li
Stem cell therapy for Parkinson's disease: where do we stand?
Cell and tissue research 2004;318(1):261-73.
2004: Helena Frielingsdorf; Katherine Schwarz; Patrik Brundin; Paul Mohapel
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10177-82.
2004: Paul Mohapel; Patrik Brundin
Harnessing endogenous stem cells to treat neurodegenerative disorders of the basal ganglia.
Parkinsonism & related disorders 2004;10(5):259-64.
2004: Joana M A C Gil; Marcel Leist; Natalija Popovic; Patrik Brundin; Asa Petersén
Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice.
BMC neuroscience 2004;5():17.
2003: Aaron Ciechanover; Patrik Brundin
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.
Neuron 2003;40(2):427-46.
2003: Jia-Yi Li; Markus Plomann; Patrik Brundin
Huntington's disease: a synaptopathy?
Trends in molecular medicine 2003;9(10):414-20.
2003: Evelise N Maciel; Gabriele S Kaminski Schierle; Oskar Hansson; Patrik Brundin; Roger F Castilho
Cyclosporin A and Bcl-2 do not inhibit quinolinic acid-induced striatal excitotoxicity in rodents.
Experimental neurology 2003;183(2):430-7.
2003: Mia Emgård; Ulrika Hallin; Jenny Karlsson; Ben A Bahr; Patrik Brundin; Klas Blomgren
Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activation.
Journal of neurochemistry 2003;86(5):1223-32.
2003: Anders Björklund; Stephen B Dunnett; Patrik Brundin; A Jon Stoessl; Curt R Freed; Robert E Breeze; Marc Levivier; Marc Peschanski; Studer Lorenz; Roger A Barker
Neural transplantation for the treatment of Parkinson's disease.
Lancet neurology 2003;2(7):437-45.
2003: Oskar Hansson; Jesper Nylandsted; Roger F Castilho; Marcel Leist; Marja Jäättelä; Patrik Brundin
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
Brain research 2003;970(1-2):47-57.
2003: Ruben Smith; Julie Lotharius; Patrik Brundin
[Free radicals and ailing proteins--the culprits behind Parkinson disease?].
Läkartidningen 2003;100(15):1324-6, 1329-30.
2003: Young Hwan Ahn; Mia Emgård; Patrik Brundin
Ultrastructural characterization of dissociated embryonic ventral mesencephalic tissue treated with neuroprotectants.
Cell transplantation 2003;12(3):235-41.
2002: Julie Lotharius; Patrik Brundin
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein.
Nature reviews. Neuroscience 2002;3(12):932-42.
2002: Jenny Karlsson; Mia Emgård; Patrik Brundin
Comparison between survival of lazaroid-treated embryonic nigral neurons in cell suspensions, cultures and transplants.
Brain research 2002;955(1-2):268-80.
2002: Julie Lotharius; Sebastian Barg; Pia Wiekop; Cecilia Lundberg; Heather K Raymon; Patrik Brundin
Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.
The Journal of biological chemistry 2002;277(41):38884-94.
2002: Asa Petersén; Zoe Puschban; Julie Lotharius; B NicNiocaill; P Wiekop; W T O'Connor; Patrik Brundin
Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice.
Neurobiology of disease 2002;11(1):134-46.
2002: Julie Lotharius; Patrik Brundin
Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease.
Human molecular genetics 2002;11(20):2395-407.
2002: Patrik Brundin
GDNF treatment in Parkinson's disease: time for controlled clinical trials?
Brain : a journal of neurology 2002;125(Pt 10):2149-51.
2002: Peter Hagell; Paola Piccini; Anders Björklund; Patrik Brundin; Stig Rehncrona; Håkan Widner; Lesley Crabb; Nicola Pavese; Wolfgang H Oertel; Niall Quinn; David J Brooks; Olle Lindvall
Dyskinesias following neural transplantation in Parkinson's disease.
Nature neuroscience 2002;5(7):627-8.
2002: Asa Petersén; Kathryn O Chase; Zoe Puschban; Marian DiFiglia; Patrik Brundin; Neil Aronin
Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease.
Experimental neurology 2002;175(1):297-300.
2002: Melinda M Zeron; Oskar Hansson; Nansheng Chen; Cheryl L Wellington; Blair R Leavitt; Patrik Brundin; Michael R Hayden; Lynn A Raymond
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease.
Neuron 2002;33(6):849-60.
2002: Gesine Paul; Jia-Yi Li; Patrik Brundin
Stem cells: hype or hope?
Drug discovery today 2002;7(5):295-302.
2002: R M Love; Richard L Branton; J Karlsson; Patrik Brundin; Deborah J Clarke
Effects of antioxidant pretreatment on the survival of embryonic dopaminergic neurons in vitro and following grafting in an animal model of Parkinson's disease.
Cell transplantation 2002;11(7):653-62.
2002: Asa Petersén; Patrik Brundin
Huntington's disease: the mystery unfolds?
International review of neurobiology 2002;53():315-39.
2002: Mia Emgård; Klas Blomgren; Patrik Brundin
Characterisation of cell damage and death in embryonic mesencephalic tissue: a study on ultrastructure, vital stains and protease activity.
Neuroscience 2002;115(4):1177-87.
2002: Gesine Paul; Patrik Brundin
Funding embryonic stem-cell research: will commerce counteract collaboration?
Drug discovery today 2002;7(1):22-3.
2001: Asa Petersén; Oskar Hansson; Patrik Brundin
[Huntington disease--yet another mad protein?].
Läkartidningen 2001;98(50):5756-8, 5761.
2001: Oskar Hansson; Ezia Guatteo; Nicola B Mercuri; Giorgio Bernardi; Xiao-Jiang Li; Roger F Castilho; Patrik Brundin
Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene.
The European journal of neuroscience 2001;14(9):1492-504.
2001: Asa Petersén; Oskar Hansson; Zoe Puschban; Ellen Sapp; N Romero; Roger F Castilho; David Sulzer; M Rice; Marian DiFiglia; Serge Przedborski; Patrik Brundin
Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine.
The European journal of neuroscience 2001;14(9):1425-35.
2001: A Petersén A; Kristin Larsen; GG Behr; N Romero; Serge Przedborski; Patrik Brundin; David Sulzer
Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death.
Brain research bulletin 2001;56(3-4):331-5.
2001: Oskar Hansson; Roger F Castilho; L Korhonen; D Lindholm; Gillian P Bates; Patrik Brundin
Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length.
Journal of neurochemistry 2001;78(4):694-703.
2001: Peter Hagell; Patrik Brundin
Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease.
Journal of neuropathology and experimental neurology 2001;60(8):741-52.
2001: Kristin Larsen; GG Behr; N Romero; Serge Przedborski; Patrik Brundin; David Sulzer
Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration.
Human molecular genetics 2001;10(12):1243-54.
2001: Patrik Brundin; Stephen B Dunnett; Anders Björklund; G Nikkhah
Transplanted dopaminergic neurons: more or less?
Nature medicine 2001;7(5):512-3.
2001: B Nicniocaill; B Haraldsson; Oskar Hansson; W T O'Connor; Patrik Brundin
Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice.
The European journal of neuroscience 2001;13(1):206-10.
2000: Paola Piccini; Olle Lindvall; Anders Björklund; Patrik Brundin; Peter Hagell; Roberto Ceravolo; Wolfgang H Oertel; Niall Quinn; M Samuel; Stig Rehncrona; Håkan Widner; David J Brooks
Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts.
Annals of neurology 2000;48(5):689-95.
2000: A Petersen; Oskar Hansson; Mia Emgård; Patrik Brundin
Grafting of nigral tissue hibernated with tirilazad mesylate and glial cell line-derived neurotrophic factor.
Cell transplantation 2000;9(5):577-84.
2000: U Mundt-Petersen; Asa Petersén; Mia Emgård; Stephen B Dunnett; Patrik Brundin
Caspase inhibition increases embryonic striatal graft survival.
Experimental neurology 2000;164(1):112-20.
2000: Oskar Hansson; Roger F Castilho; Gabriele S Kaminski Schierle; Jenny Karlsson; Pierluigi Nicotera; Marcel Leist; Patrik Brundin
Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons.
Experimental neurology 2000;164(1):102-11.
2000: Roger F Castilho; Oskar Hansson; Patrik Brundin
FK506 and cyclosporin A enhance the survival of cultured and grafted rat embryonic dopamine neurons.
Experimental neurology 2000;164(1):94-101.
2000: Patrik Brundin; O Pogarell; Peter Hagell; Paola Piccini; Håkan Widner; A Schrag; Andreas Kupsch; Lesley Crabb; P Odin; B Gustavii; Anders Björklund; David J Brooks; CD Marsden; Wolfgang H Oertel; Niall Quinn; Stig Rehncrona; Olle Lindvall
Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease.
Brain : a journal of neurology 2000;123 ( Pt 7)():1380-90.
2000: Jenny Karlsson; M Emgard; Patrik Brundin; M J Burkitt
trans-resveratrol protects embryonic mesencephalic cells from tert-butyl hydroperoxide: electron paramagnetic resonance spin trapping evidence for a radical scavenging mechanism.
Journal of neurochemistry 2000;75(1):141-50.
2000: Jenny Karlsson; Mia Emgård; Gunilla Gidö; Tadeusz Wieloch; Patrik Brundin
Increased survival of embryonic nigral neurons when grafted to hypothermic rats.
Neuroreport 2000;11(8):1665-8.
2000: Lena C Larsson; Kimberly Ann Czech; Patrik Brundin; Håkan Widner
Intrastriatal ventral mesencephalic xenografts of porcine tissue in rats: immune responses and functional effects.
Cell transplantation 2000;9(2):261-72.
2000: Patrik Brundin; Jenny Karlsson; Mia Emgård; GS Schierle; Oskar Hansson; Asa Petersén; Roger F Castilho
Improving the survival of grafted dopaminergic neurons: a review over current approaches.
Cell transplantation 2000;9(2):179-95.
2000: Asa Petersén; Roger F Castilho; Oskar Hansson; Tadeusz Wieloch; Patrik Brundin
Oxidative stress, mitochondrial permeability transition and activation of caspases in calcium ionophore A23187-induced death of cultured striatal neurons.
Brain research 2000;857(1-2):20-9.
2000: Roger F Castilho; Oskar Hansson; Patrik Brundin
Improving the survival of grafted embryonic dopamine neurons in rodent models of Parkinson's disease.
Progress in brain research 2000;127():203-31.
2000: U Mundt-Petersen; J Karlsson; G S Schierle; Patrik Brundin
Pretreatment with MK-801 or the lazaroid U-83836E does not enhance striatal graft survival.
Cell transplantation 2000;9(1):73-8.
1999: Asa Petersén; Patrik Brundin
Effects of ciliary neurotrophic factor on excitotoxicity and calcium-ionophore A23187-induced cell death in cultured embryonic striatal neurons.
Experimental neurology 1999;160(2):402-12.
1999: Paola Piccini; David J Brooks; Anders Björklund; Roger Gunn; Paul M Grasby; Ornella E Rimoldi; Patrik Brundin; Peter Hagell; Stig Rehncrona; Håkan Widner; Olle Lindvall
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient.
Nature neuroscience 1999;2(12):1137-40.
1999: Gabriele S Kaminski Schierle; Oskar Hansson; Elisa Ferrando-May; Pierluigi Nicotera; Patrik Brundin; Marcel Leist
Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation.
Neuroreport 1999;10(16):3347-51.
1999: Mia Emgård; Jenny Karlsson; Oskar Hansson; Patrik Brundin
Patterns of cell death and dopaminergic neuron survival in intrastriatal nigral grafts.
Experimental neurology 1999;160(1):279-88.
1999: Asa Petersén; Mia Emgård; Patrik Brundin
Impact of a preceding striatal excitotoxic lesion and treatment with ciliary neurotrophic factor on striatal graft survival.
Brain research bulletin 1999;50(4):275-81.
1999: GS Schierle; Marcel Leist; J C Martinou; Håkan Widner; Pierluigi Nicotera; Patrik Brundin
Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants.
The European journal of neuroscience 1999;11(9):3073-81.
1999: Oskar Hansson; Asa Petersén; Marcel Leist; Pierluigi Nicotera; Roger F Castilho; Patrik Brundin
Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8727-32.
1999: GS Schierle; Patrik Brundin
Excitotoxicity plays a role in the death of tyrosine hydroxylase- immunopositive nigral neurons cultured in serum-free medium.
Experimental neurology 1999;157(2):338-48.
1999: Peter Hagell; A Schrag; Paola Piccini; Marjan Jahanshahi; R Brown; Stig Rehncrona; Håkan Widner; Patrik Brundin; John C Rothwell; P Odin; Gregor Wenning; PK Morrish; B Gustavii; Anders Björklund; David J Brooks; CD Marsden; Niall Quinn; Olle Lindvall
Sequential bilateral transplantation in Parkinson's disease: effects of the second graft.
Brain : a journal of neurology 1999;122 ( Pt 6)():1121-32.
1999: A Petersén; K Mani; Patrik Brundin
Recent advances on the pathogenesis of Huntington's disease.
Experimental neurology 1999;157(1):1-18.
1999: T Grasbon; E M Grasbon-Frodl; B Juliusson; C Epstein; Patrik Brundin; A Kampik; Berndt Ehinger
CuZn superoxide dismutase transgenic retinal transplants.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 1999;237(4):336-41.
1999: Patrik Brundin; Asa Petersén; Oskar Hansson
Graft survival.
Journal of neurosurgery 1999;90(4):804-6.
1999: Jenny Karlsson; R M Love; D J Clarke; Patrik Brundin
Effects of anaesthetics and lazaroid U-83836E on survival of transplanted rat dopaminergic neurones.
Brain research 1999;821(2):546-50.
1999: Gabriele S Kaminski Schierle; Oskar Hansson; Patrik Brundin
Flunarizine improves the survival of grafted dopaminergic neurons.
Neuroscience 1999;94(1):17-20.
1999: Paul Sanberg; Patrik Brundin
Cell transplantation and neuroscience.
Cell transplantation 1999;8(1):3-6.
1999: GS Schierle; Oskar Hansson; Marcel Leist; Pierluigi Nicotera; Håkan Widner; Patrik Brundin
Caspase inhibition reduces apoptosis and increases survival of nigral transplants.
Nature medicine 1999;5(1):97-100.
1998: Patrik Brundin; Anders Björklund
Survival of expanded dopaminergic precursors is critical for clinical trials.
Nature neuroscience 1998;1(7):537.
1998: J Karlsson; M Emgârd; C Rosenblad; Patrik Brundin
Treatment with the spin-trap agent alpha-phenyl-N-tert-butyl nitrone does not enhance the survival of embryonic or adult dopamine neurons.
Brain research 1998;805(1-2):155-68.
1998: WM Duan; Håkan Widner; R M Cameron; Patrik Brundin
Quinolinic acid-induced inflammation in the striatum does not impair the survival of neural allografts in the rat.
The European journal of neuroscience 1998;10(8):2595-606.
1998: G S Schierle; J Karlsson; Patrik Brundin
MK-801 does not enhance dopaminergic cell survival in embryonic nigral grafts.
Neuroreport 1998;9(7):1313-6.
1998: N Nakao; Patrik Brundin
Neurodegeneration and glutamate induced oxidative stress.
Progress in brain research 1998;116():245-63.
1997: WM Duan; R M Cameron; Patrik Brundin; Håkan Widner
Rat intrastriatal neural allografts challenged with skin allografts at different time points.
Experimental neurology 1997;148(1):334-47.
1997: Agneta SanMartin; M Keep; Patrik Brundin; Olle Lindvall
Tirilazad mesylate improves survival of rat and human embryonic mesencephalic neurons in vitro.
Experimental neurology 1997;147(2):498-502.
1997: Gregor Wenning; P Odin; PK Morrish; Stig Rehncrona; Håkan Widner; Patrik Brundin; John C Rothwell; Richard G Brown; B Gustavii; Peter Hagell; Marjan Jahanshahi; Guy V Sawle; Anders Björklund; David J Brooks; CD Marsden; Niall Quinn; Olle Lindvall
Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease.
Annals of neurology 1997;42(1):95-107.
1997: Martine Barkats; N Nakao; E M Grasbon-Frodl; Alicia Bilang-Bleuel; F Revah; Jacques Mallet; Patrik Brundin
Intrastriatal grafts of embryonic mesencephalic rat neurons genetically modified using an adenovirus encoding human Cu/Zn superoxide dismutase.
Neuroscience 1997;78(3):703-13.
1997: M Emgård-Mattson; J Karlsson; N Nakao; Patrik Brundin
Addition of lateral ganglionic eminence to rat mesencephalic grafts affects fiber outgrowth but does not enhance function.
Cell transplantation 1997;6(3):277-86.
1997: WM Duan; Patrik Brundin; Håkan Widner
Addition of allogeneic spleen cells causes rejection of intrastriatal embryonic mesencephalic allografts in the rat.
Neuroscience 1997;77(2):599-609.
1997: N Nakao; Patrik Brundin
Effects of alpha-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid.
Neuroscience 1997;76(3):749-61.
1997: E M Grasbon-Frodl; N Nakao; O Lindvall; Patrik Brundin
Developmental features of human striatal tissue transplanted in a rat model of Huntington's disease.
Neurobiology of disease 1997;3(4):299-311.
1997: E M Grasbon-Frodl; Patrik Brundin
Mesencephalic neuron death induced by congeners of nitrogen monoxide is prevented by the lazaroid U-83836E.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1997;113(1):138-43.
1996: N Nakao; E M Grasbon-Frodl; Håkan Widner; Patrik Brundin
DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease.
Neuroscience 1996;74(4):959-70.
1996: E M Grasbon-Frodl; A Andersson; Patrik Brundin
Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion.
Journal of neurochemistry 1996;67(4):1653-60.
1996: N Nakao; E M Grasbon-Frodl; Håkan Widner; Patrik Brundin
Antioxidant treatment protects striatal neurons against excitotoxic insults.
Neuroscience 1996;73(1):185-200.
1996: E M Grasbon-Frodl; Naoyuki Nakao; O Lindvall; Patrik Brundin
Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminences.
Neuroscience 1996;73(1):171-83.
1996: Patrik Brundin; R A Fricker; N Nakao
Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease.
Neuroscience 1996;71(3):895-97.
1996: WM Duan; Patrik Brundin; E M Grasbon-Frodl; Håkan Widner
Methylprednisolone prevents rejection of intrastriatal grafts of xenogeneic embryonic neural tissue in adult rats.
Brain research 1996;712(2):199-212.
1996: N Nakao; P Odin; O Lindvall; Patrik Brundin
Differential trophic effects of basic fibroblast growth factor, insulin-like growth factor-1, and neurotrophin-3 on striatal neurons in culture.
Experimental neurology 1996;138(1):144-57.
1996: E M Grasbon-Frodl; N Nakao; Patrik Brundin
The lazaroid U-83836E improves the survival of rat embryonic mesencephalic tissue stored at 4 degrees C and subsequently used for cultures or intracerebral transplantation.
Brain research bulletin 1996;39(6):341-7.
1996: M Grabowski; Barbro B Johansson; Patrik Brundin
Fetal neocortical grafts placed in brain infarcts do not improve paw-reaching deficits in adult spontaneously hypertensive rats.
Acta neurochirurgica. Supplement 1996;66():68-72.
1995: N Nakao; Patrik Brundin; K Funa; Olle Lindvall; P Odin
Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro.
Brain research. Developmental brain research 1995;90(1-2):92-101.
1995: E M Frodl; H Sauer; Olle Lindvall; Patrik Brundin
Effects of hibernation or cryopreservation on the survival and integration of striatal grafts placed in the ibotenate-lesioned rat caudate-putamen.
Cell transplantation 1995;4(6):571-7.
1995: M Grabowski; Barbro B Johansson; Patrik Brundin
Neocortical grafts placed in the infarcted brain of adult rats: few or no efferent fibers grow from transplant to host.
Experimental neurology 1995;134(2):273-6.
1995: N Nakao; E M Frodl; Håkan Widner; E Carlson; F A Eggerding; C J Epstein; Patrik Brundin
Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease.
Nature medicine 1995;1(3):226-31.
1995: WM Duan; Håkan Widner; E M Frodl; Patrik Brundin
Immune reactions following systemic immunization prior or subsequent to intrastriatal transplantation of allogeneic mesencephalic tissue in adult rats.
Neuroscience 1995;64(3):629-41.
1995: WM Duan; Håkan Widner; Patrik Brundin
Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1995;104(2):227-42.
1994: N Nakao; E M Frodl; WM Duan; Håkan Widner; Patrik Brundin
Lazaroids improve the survival of grafted rat embryonic dopamine neurons.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12408-12.
1994: E M Frodl; N Nakao; Patrik Brundin
Lazaroids improve the survival of cultured rat embryonic mesencephalic neurones.
Neuroreport 1994;5(17):2393-6.
1994: E M Frodl; WM Duan; H Sauer; Andreas Kupsch; Patrik Brundin
Human embryonic dopamine neurons xenografted to the rat: effects of cryopreservation and varying regional source of donor cells on transplant survival, morphology and function.
Brain research 1994;647(2):286-98.
1994: N Nakao; P Odin; Patrik Brundin
Selective sub-dissection of the striatal primordium for cultures affects the yield of DARPP-32-containing neurones.
Neuroreport 1994;5(9):1081-4.
1994: M Grabowski; Barbro B Johansson; Patrik Brundin
Survival of fetal neocortical grafts implanted in brain infarcts of adult rats: the influence of postlesion time and age of donor tissue.
Experimental neurology 1994;127(1):126-36.
1994: Olle Lindvall; Guy V Sawle; Håkan Widner; John C Rothwell; Anders Björklund; David J Brooks; Patrik Brundin; Richard S J Frackowiak; CD Marsden; P Odin
Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease.
Annals of neurology 1994;35(2):172-80.
1994: N Nakao; Patrik Brundin; Keiko Funa; Olle Lindvall; P Odin
Platelet-derived growth factor exerts trophic effects on rat striatal DARPP-32-containing neurons in culture.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1994;101(2):291-6.
1993: WM Duan; Håkan Widner; Anders Björklund; Patrik Brundin
Sequential intrastriatal grafting of allogeneic embryonic dopamine-rich neuronal tissue in adult rats: will the second graft be rejected?
Neuroscience 1993;57(2):261-74.
1993: H Sauer; W Fischer; G Nikkhah; S J Wiegand; Patrik Brundin; Ronald Lindsay; Anders Björklund
Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts.
Brain research 1993;626(1-2):37-44.
1993: M Grabowski; Patrik Brundin; Barbro B Johansson
Functional integration of cortical grafts placed in brain infarcts of rats.
Annals of neurology 1993;34(3):362-8.
1993: Håkan Widner; Patrik Brundin
Sequential intracerebral transplantation of allogeneic and syngeneic fetal dopamine-rich neuronal tissue in adult rats: will the first graft be rejected?
Cell transplantation 1993;2(4):307-17.
1993: M Grabowski; Patrik Brundin; Barbro B Johansson
Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats.
Stroke; a journal of cerebral circulation 1993;24(6):889-95.
1993: A Smits; P Odin; WM Duan; Patrik Brundin; Håkan Widner; Carl-Henrik Heldin; Olle Lindvall; Keiko Funa
Expression of platelet-derived growth factor in and around intrastriatal embryonic mesencephalic grafts.
Cell transplantation 1993;2(2):151-62.
1993: Håkan Widner; J Tetrud; Stig Rehncrona; B J Snow; Patrik Brundin; Anders Björklund; Olle Lindvall; J William Langston
Fifteen months' follow-up on bilateral embryonic mesencephalic grafts in two cases of severe MPTP-induced parkinsonism.
Advances in neurology 1993;60():729-33.
1993: G Nikkhah; P Odin; A Smits; A Tingström; Agneta SanMartin; Patrik Brundin; Keiko Funa; Olle Lindvall
Platelet-derived growth factor promotes survival of rat and human mesencephalic dopaminergic neurons in culture.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1993;92(3):516-23.
1992: M Grabowski; R H Christofferson; Patrik Brundin; Barbro B Johansson
Vascularization of fetal neocortical grafts implanted in brain infarcts in spontaneously hypertensive rats.
Neuroscience 1992;51(3):673-82.
1992: Håkan Widner; J Tetrud; Stig Rehncrona; B Snow; Patrik Brundin; B Gustavii; Anders Björklund; Olle Lindvall; J William Langston
Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
The New England journal of medicine 1992;327(22):1556-63.
1992: K Wictorin; Patrik Brundin; H Sauer; Olle Lindvall; Anders Björklund
Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats.
The Journal of comparative neurology 1992;323(4):475-94.
1992: M Grabowski; Patrik Brundin; Barbro B Johansson
Fetal neocortical grafts implanted in adult hypertensive rats with cortical infarcts following a middle cerebral artery occlusion: ingrowth of afferent fibers from the host brain.
Experimental neurology 1992;116(2):105-21.
1992: Guy V Sawle; Peter M Bloomfield; Anders Björklund; David J Brooks; Patrik Brundin; Klaus L Leenders; Olle Lindvall; CD Marsden; Stig Rehncrona; Håkan Widner
Transplantation of fetal dopamine neurons in Parkinson's disease: PET [18F]6-L-fluorodopa studies in two patients with putaminal implants.
Annals of neurology 1992;31(2):166-73.
1992: Olle Lindvall; Håkan Widner; Stig Rehncrona; Patrik Brundin; P Odin; B Gustavii; Richard S J Frackowiak; Klaus L Leenders; Guy V Sawle; John C Rothwell
Transplantation of fetal dopamine neurons in Parkinson's disease: one-year clinical and neurophysiological observations in two patients with putaminal implants.
Annals of neurology 1992;31(2):155-65.
1991: Håkan Widner; Patrik Brundin; Stig Rehncrona; B Gustavii; Richard S J Frackowiak; Klaus L Leenders; Guy V Sawle; John C Rothwell; CD Marsden; Anders Björklund
Transplanted allogeneic fetal dopamine neurons survive and improve motor function in idiopathic Parkinson's disease.
Transplantation proceedings 1991;23(1 Pt 1):793-5.
1991: Hansjörg Sauer; Patrik Brundin
Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts.
Restorative neurology and neuroscience 1991;2(3):123-35.
1991: Johan Bengzon; Patrik Brundin; P Kalén; Merab Kokaia; Olle Lindvall
Host regulation of noradrenaline release from grafts of seizure-suppressant locus coeruleus neurons.
Experimental neurology 1991;111(1):49-54.
1991: Philippe Horellou; C Lundberg; B Le Bourdellès; K Wictorin; Patrik Brundin; P Kalén; Anders Björklund; Jacques Mallet
Behavioural effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease.
Journal de physiologie 1991;85(3):158-70.
1990: O Lindvall; Patrik Brundin; Håkan Widner; Stig Rehncrona; B Gustavii; R Frackowiak; Klaus L Leenders; Guy V Sawle; J C Rothwell; C D Marsden; A Björklund
In reply: fetal brain grafts and Parkinson's disease.
Science (New York, N.Y.) 1990;250(4986):1435.
1990: Y Murata; T Chiba; Patrik Brundin; Anders Björklund; O Lindvall
Formation of synaptic graft-host connections by noradrenergic locus coeruleus neurons transplanted into the adult rat hippocampus.
Experimental neurology 1990;110(3):258-67.
1990: Patrik Brundin; P Odin; Håkan Widner
[Promising new results with transplantation of nerve cells to the brain in Parkinson disease].
Läkartidningen 1990;87(45):3761-3.
1990: K Wictorin; Patrik Brundin; B Gustavii; Olle Lindvall; Anders Björklund
Reformation of long axon pathways in adult rat central nervous system by human forebrain neuroblasts.
Nature 1990;347(6293):556-8.
1990: Philippe Horellou; Patrik Brundin; P Kalén; Jacques Mallet; Anders Björklund
In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum.
Neuron 1990;5(4):393-402.
1990: O G Nilsson; Patrik Brundin; Anders Björklund
Amelioration of spatial memory impairment by intrahippocampal grafts of mixed septal and raphe tissue in rats with combined cholinergic and serotonergic denervation of the forebrain.
Brain research 1990;515(1-2):193-206.
1990: Olle Lindvall; Patrik Brundin; Håkan Widner; Stig Rehncrona; B Gustavii; Richard S J Frackowiak; Klaus L Leenders; Guy V Sawle; John C Rothwell; CD Marsden
Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease.
Science (New York, N.Y.) 1990;247(4942):574-7.
1990: R Aramant; M Seiler; B Ehinger; A Bergström; B Gustavii; Patrik Brundin; A R Adolph
Transplantation of human embryonic retina to adult rat retina.
Restorative neurology and neuroscience 1990;2(1):9-22.
1990: D J Clarke; O G Nilsson; Patrik Brundin; Anders Björklund
Synaptic connections formed by grafts of different types of cholinergic neurons in the host hippocampus.
Experimental neurology 1990;107(1):11-22.
1990: Olle Lindvall; Stig Rehncrona; Patrik Brundin; B Gustavii; B Astedt; Håkan Widner; T Lindholm; Anders Björklund; Klaus L Leenders; John C Rothwell
Neural transplantation in Parkinson's disease: the Swedish experience.
Progress in brain research 1990;82():729-34.
1990: Patrik Brundin; Anders Björklund; Olle Lindvall
Practical aspects of the use of human fetal brain tissue for intracerebral grafting.
Progress in brain research 1990;82():707-14.
1990: Johan Bengzon; Merab Kokaia; Patrik Brundin; Olle Lindvall
Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;81(2):433-7.
1990: Lazaros C Triarhou; Patrik Brundin; G Doucet; J Norton; Anders Björklund; Bernardino Ghetti
Intrastriatal implants of mesencephalic cell suspensions in weaver mutant mice: ultrastructural relationships of dopaminergic dendrites and axons issued from the graft.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1990;79(1):3-17.
1990: Olle Lindvall; Johan Bengzon; Patrik Brundin; P Kalén; Merab Kokaia
Locus coeruleus grafts in hippocampal kindling epilepsy: noradrenaline release, receptor specificity and influence on seizure development.
Progress in brain research 1990;82():339-46.
1990: K Wictorin; D J Clarke; J P Bolam; Patrik Brundin; B Gustavii; Olle Lindvall; Anders Björklund
Extensive efferent projections of intra-striatally transplanted striatal neurons as revealed by a species-specific neurofilament marker and anterograde axonal tracing.
Progress in brain research 1990;82():391-9.
1989: D I Barry; B Wanscher; J Kragh; Tom G Bolwig; M Kokaia; Patrik Brundin; Anders Björklund; O Lindvall
Grafts of fetal locus coeruleus neurons in rat amygdala-piriform cortex suppress seizure development in hippocampal kindling.
Experimental neurology 1989;106(2):125-32.
1989: A Daszuta; P Kalén; R E Strecker; Patrik Brundin; Anders Björklund
Serotonin neurons grafted to the adult rat hippocampus. II. 5-HT release as studied by intracerebral microdialysis.
Brain research 1989;498(2):323-32.
1989: Guy Doucet; Y Murata; Patrik Brundin; Olivier Bosler; N Mons; M Geffard; C C Ouimet; Anders Björklund
Host afferents into intrastriatal transplants of fetal ventral mesencephalon.
Experimental neurology 1989;106(1):1-19.
1989: Olle Lindvall; Stig Rehncrona; Patrik Brundin; B Gustavii; B Astedt; Håkan Widner; T Lindholm; Anders Björklund; Klaus L Leenders; John C Rothwell; R Frackowiak; D Marsden; B Johnels; G Steg; R Freedman; B J Hoffer; A Seiger; M Bygdeman; I Strömberg; L Olson
Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up.
Archives of neurology 1989;46(6):615-31.
1989: Håkan Widner; Patrik Brundin; Anders Björklund; E Möller
Survival and immunogenicity of dissociated allogeneic fetal neural dopamine-rich grafts when implanted into the brains of adult mice.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1989;76(1):187-97.
1989: G Doucet; Patrik Brundin; S Seth; Y Murata; R E Strecker; Lazaros C Triarhou; Bernardino Ghetti; Anders Björklund
Degeneration and graft-induced restoration of dopamine innervation in the weaver mouse neostriatum: a quantitative radioautographic study of [3H]dopamine uptake.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1989;77(3):552-68.
1989: C Forni; Patrik Brundin; R E Strecker; S el Ganouni; Anders Björklund; A Nieoullon
Time-course of recovery of dopamine neuron activity during reinnervation of the denervated striatum by fetal mesencephalic grafts as assessed by in vivo voltammetry.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1989;76(1):75-87.
1989: Patrik Brundin; Håkan Widner; O G Nilsson; R E Strecker; Anders Björklund
Intracerebral xenografts of dopamine neurons: the role of immunosuppression and the blood-brain barrier.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1989;75(1):195-207.
1988: O Lindvall; Stig Rehncrona; B Gustavii; Patrik Brundin; B Astedt; Håkan Widner; T Lindholm; Anders Björklund; Klaus L Leenders; John C Rothwell; R Frackowiak; C D Marsden; B Johnels; G Steg; R Freedman; B J Hoffer; L Seiger; I Strömberg; M Bygdeman; L Olson
Fetal dopamine-rich mesencephalic grafts in Parkinson's disease.
Lancet 1988;2(8626-8627):1483-4.
1988: Håkan Widner; Patrik Brundin
Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis.
Brain research 1988;472(3):287-324.
1988: A Daszuta; R E Strecker; Patrik Brundin; Anders Björklund
Serotonin neurons grafted to the adult rat hippocampus. I. Time course of growth as studied by immunohistochemistry and biochemistry.
Brain research 1988;458(1):1-19.
1988: O G Nilsson; Patrik Brundin; Håkan Widner; R E Strecker; Anders Björklund
Human fetal basal forebrain neurons grafted to the denervated rat hippocampus produce an organotypic cholinergic reinnervation pattern.
Brain research 1988;456(1):193-8.
1988: M Grabowski; C Nordborg; Patrik Brundin; Barbro B Johansson
Middle cerebral artery occlusion in the hypertensive and normotensive rat: a study of histopathology and behaviour.
Journal of hypertension 1988;6(5):405-11.
1988: Patrik Brundin; G Barbin; R E Strecker; Ole Isacson; A Prochiantz; Anders Björklund
Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro.
Brain research 1988;467(2):233-43.
1988: O G Nilsson; D J Clarke; Patrik Brundin; Anders Björklund
Comparison of growth and reinnervation properties of cholinergic neurons from different brain regions grafted to the hippocampus.
The Journal of comparative neurology 1988;268(2):204-22.
1988: Patrik Brundin; R E Strecker; Håkan Widner; D J Clarke; O G Nilsson; B Astedt; Olle Lindvall; Anders Björklund
Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1988;70(1):192-208.
1988: Fred H Gage; Patrik Brundin; R Strecker; Stephen B Dunnett; Ole Isacson; Anders Björklund
Intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction.
Annals of the New York Academy of Sciences 1988;515():383-94.
1988: Anders Björklund; Patrik Brundin; Ole Isacson
Neuronal replacement by intracerebral neural implants in animal models of neurodegenerative disease.
Advances in neurology 1988;47():455-92.
1988: Håkan Widner; Patrik Brundin; Anders Björklund; E Möller
Immunological aspects of neural grafting in the mammalian central nervous system.
Progress in brain research 1988;78():303-7.
1988: D J Clarke; Patrik Brundin; R E Strecker; O G Nilsson; Anders Björklund; Olle Lindvall
Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1988;73(1):115-26.
1988: O Lindvall; D I Barry; I Kikvadze; Patrik Brundin; T G Bolwig; Anders Björklund
Intracerebral grafting of fetal noradrenergic locus coeruleus neurons: evidence for seizure suppression in the kindling model of epilepsy.
Progress in brain research 1988;78():79-86.
1988: Patrik Brundin; R E Strecker; D J Clarke; Håkan Widner; O G Nilsson; B Astedt; O Lindvall; Anders Björklund
Can human fetal dopamine neuron grafts provide a therapy for Parkinson's disease?
Progress in brain research 1988;78():441-8.
1988: Patrik Brundin; R E Strecker; F H Gage; Olle Lindvall; Anders Björklund
Intracerebral transplantation of dopamine neurons: understanding the functional role of the mesolimbocortical dopamine system and developing a therapy for Parkinson's disease.
Annals of the New York Academy of Sciences 1988;537():148-60.
1987: D I Barry; I Kikvadze; Patrik Brundin; Tom G Bolwig; Anders Björklund; O Lindvall
Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8712-5.
1987: Ole Isacson; D Dawbarn; Patrik Brundin; F H Gage; P C Emson; Anders Björklund
Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography.
Neuroscience 1987;22(2):481-97.
1987: R E Strecker; T Sharp; Patrik Brundin; T Zetterström; U Ungerstedt; Anders Björklund
Autoregulation of dopamine release and metabolism by intrastriatal nigral grafts as revealed by intracerebral dialysis.
Neuroscience 1987;22(1):169-78.
1987: Patrik Brundin; Anders Björklund
Survival, growth and function of dopaminergic neurons grafted to the brain.
Progress in brain research 1987;71():293-308.
1987: Ole Isacson; M Pritzel; D Dawbarn; Patrik Brundin; P A Kelly; L Wiklund; P C Emson; F H Gage; Stephen B Dunnett; Anders Björklund
Striatal neural transplants in the ibotenic acid-lesioned rat neostriatum. Cellular and functional aspects.
Annals of the New York Academy of Sciences 1987;495():537-55.
1987: Patrik Brundin; R E Strecker; O Lindvall; Ole Isacson; O G Nilsson; G Barbin; A Prochiantz; C Forni; A Nieoullon; Håkan Widner
Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease.
Annals of the New York Academy of Sciences 1987;495():473-96.
1987: Patrik Brundin; R E Strecker; E Londos; Anders Björklund
Dopamine neurons grafted unilaterally to the nucleus accumbens affect drug-induced circling and locomotion.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1987;69(1):183-94.
1986: Patrik Brundin; Ole Isacson; F H Gage; A Prochiantz; Anders Björklund
The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting.
Brain research 1986;366(1-2):346-9.
1986: T Zetterström; Patrik Brundin; F H Gage; T Sharp; Ole Isacson; Stephen B Dunnett; U Ungerstedt; Anders Björklund
In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis.
Brain research 1986;362(2):344-9.
1986: Patrik Brundin; O G Nilsson; R E Strecker; Olle Lindvall; B Astedt; Anders Björklund
Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1986;65(1):235-40.
1986: Patrik Brundin; Ole Isacson; F H Gage; Anders Björklund
Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells.
Brain research 1986;389(1-2):77-84.
1986: M Pritzel; Ole Isacson; Patrik Brundin; L Wiklund; Anders Björklund
Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1986;65(1):112-26.
1985: Ole Isacson; Patrik Brundin; F H Gage; Anders Björklund
Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting.
Neuroscience 1985;16(4):799-817.
1985: Patrik Brundin; G Barbin; Ole Isacson; Michel Mallat; B Chamak; Alain Prochiantz; F H Gage; Anders Björklund
Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro.
Neuroscience letters 1985;61(1-2):79-84.
1985: F H Gage; Patrik Brundin; Ole Isacson; Anders Björklund
Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage.
Neuroscience letters 1985;60(2):133-7.
1985: Patrik Brundin; Ole Isacson; Anders Björklund
Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival.
Brain research 1985;331(2):251-9.
1985: Patrik Brundin; O G Nilsson; F H Gage; Anders Björklund
Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1985;60(1):204-8.
1985: P C Emson; D Dawbarn; Martin N Rossor; J F Rehfeld; Patrik Brundin; Ole Isacson; Anders Björklund
Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum.
Annals of the New York Academy of Sciences 1985;448():488-94.
1984: Ole Isacson; Patrik Brundin; P A Kelly; F H Gage; Anders Björklund
Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum.
Nature 1984;311(5985):458-60.
1983: F H Gage; Stephen B Dunnett; Patrik Brundin; Ole Isacson; Anders Björklund
Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application.
Developmental neuroscience 1983;6(3):137-51.