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Bernhard Brüne

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
30
Zhou, Jie
23
von Knethen, Andreas
18
Sandau, KB
14
von Knethen, A
12
Weigert, Andreas
12
Ullrich, Volker
9
Schmid, Tobias
8
Dimmeler, Stefanie
7
Köhl, Roman
6
Pfeilschifter, Josef
6
Callsen, D
6
Johann, Axel
4
Brockhaus, F
4
Namgaladze, Dmitry
4
Schnitzer, Steffen

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Publications

TOP 3
Essler Silke; Dehne Nathalie; Brüne Bernhard
Role of sestrin2 in peroxide signaling in macrophages.
Weigert Andreas; Schiffmann Susanne; Sekar Divya; Ley Stephanie; Menrad Heidi; Werno Christian; Grosch Sabine; Geisslinger Gerd; Brüne Bernhard
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
Herr Barbara; Zhou Jie; Werno Christian; Menrad Heidi; Namgaladze Dmitry; Weigert Andreas; Dehne Nathalie; Brüne Bernhard
The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.

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All Publications

2009: Essler Silke; Dehne Nathalie; Brüne Bernhard
Role of sestrin2 in peroxide signaling in macrophages.
FEBS letters 2009;583(21):3531-5.
2009: Weigert Andreas; Schiffmann Susanne; Sekar Divya; Ley Stephanie; Menrad Heidi; Werno Christian; Grosch Sabine; Geisslinger Gerd; Brüne Bernhard
Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
International journal of cancer. Journal international du cancer 2009;125(9):2114-21.
2009: Herr Barbara; Zhou Jie; Werno Christian; Menrad Heidi; Namgaladze Dmitry; Weigert Andreas; Dehne Nathalie; Brüne Bernhard
The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.
Blood 2009;114(10):2140-8.
2009: Zhou Jie; Dehne Nathalie; Brüne Bernhard
Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1.
Free radical biology & medicine 2009;47(6):741-9.
2009: Dehne Nathalie; Brüne Bernhard
HIF-1 in the inflammatory microenvironment.
Experimental cell research 2009;315(11):1791-7.
2009: Weigert Andreas; Jennewein Carla; Brüne Bernhard
The liaison between apoptotic cells and macrophages--the end programs the beginning.
Biological chemistry 2009;390(5-6):379-90.
2009: Schnitzer Steffen E; Weigert Andreas; Zhou Jie; Brüne Bernhard
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells.
Molecular cancer research : MCR 2009;7(3):393-401.
2009: Weis Nicole; Weigert Andreas; von Knethen Andreas; Brüne Bernhard
Heme oxygenase-1 contributes to an alternative macrophage activation profile induced by apoptotic cell supernatants.
Molecular biology of the cell 2009;20(5):1280-8.
2009: Igwe Emeka I; Essler Silke; Al-Furoukh Natalie; Dehne Nathalie; Brüne Bernhard
Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics.
BMC genomics 2009;10():408.
2009: Weigert Andreas; Weis Nicole; Brüne Bernhard
Regulation of macrophage function by sphingosine-1-phosphate.
Immunobiology 2009;214(9-10):748-60.
2008: Igwe Emeka; Kosan Christian; Khandanpour Cyrus; Sharif-Askari Ehssan; Brüne Bernhard; Möröy Tarik
The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts.
European journal of immunology 2008;38(11):3004-14.
2008: Jennewein Carla; Kuhn Anne-Marie; Schmidt Martina Victoria; Meilladec-Jullig Virginie; von Knethen Andreas; Gonzalez Frank J; Brüne Bernhard
Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(8):5646-52.
2008: Weigert Andreas; Brüne Bernhard
Nitric oxide, apoptosis and macrophage polarization during tumor progression.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;19(2):95-102.
2008: Werno Christian; Zhou Jie; Brüne Bernhard
A23187, ionomycin and thapsigargin upregulate mRNA of HIF-1alpha via endoplasmic reticulum stress rather than a rise in intracellular calcium.
Journal of cellular physiology 2008;215(3):708-14.
2008: Johann Axel M; Weigert Andreas; Eberhardt Wolfgang; Kuhn Anne-Marie; Barra Vera; von Knethen Andreas; Pfeilschifter Josef M; Brüne Bernhard
Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1239-48.
2008: Zhou Jie; Eleni Chantzoura; Spyrou Giannis; Brüne Bernhard
The mitochondrial thioredoxin system regulates nitric oxide-induced HIF-1alpha protein.
Free radical biology & medicine 2008;44(1):91-8.
2008: Namgaladze Dmitry; Kollas Andreas; Brüne Bernhard
Oxidized LDL attenuates apoptosis in monocytic cells by activating ERK signaling.
Journal of lipid research 2008;49(1):58-65.
2007: Herr B; Zhou J; Dröse S; Brüne B
The interaction of superoxide with nitric oxide destabilizes hypoxia-inducible factor-1alpha.
Cellular and molecular life sciences : CMLS 2007;64(24):3295-305.
2007: Weigert Andreas; Tzieply Nico; von Knethen Andreas; Johann Axel M; Schmidt Helmut; Geisslinger Gerd; Brüne Bernhard
Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.
Molecular biology of the cell 2007;18(10):3810-9.
2007: Johann Axel M; Barra Vera; Kuhn Anne-Marie; Weigert Andreas; von Knethen Andreas; Brüne Bernhard
Apoptotic cells induce arginase II in macrophages, thereby attenuating NO production.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(11):2704-12.
2007: Brüne Bernhard; Zhou Jie
Nitric oxide and superoxide: interference with hypoxic signaling.
Cardiovascular research 2007;75(2):275-82.
2007: Soller Mathias; Dröse Stefan; Brandt Ulrich; Brüne Bernhard; von Knethen Andreas
Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.
Molecular pharmacology 2007;71(6):1535-44.
2007: Preiss Stefan; Namgaladze Dmitry; Brüne Bernhard
Critical role for classical PKC in activating Akt by phospholipase A2-modified LDL in monocytic cells.
Cardiovascular research 2007;73(4):833-40.
2007: Zhou Jie; Damdimopoulos Anastassios E; Spyrou Giannis; Brüne Bernhard
Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha.
The Journal of biological chemistry 2007;282(10):7482-90.
2007: von Knethen Andreas; Soller Mathias; Tzieply Nico; Weigert Andreas; Johann Axel M; Jennewein Carla; Köhl Roman; Brüne Bernhard
PPARgamma1 attenuates cytosol to membrane translocation of PKCalpha to desensitize monocytes/macrophages.
The Journal of cell biology 2007;176(5):681-94.
2007: von Knethen Andreas; Soller Mathias; Brüne Bernhard
Peroxisome proliferator-activated receptor gamma (PPAR gamma) and sepsis.
Archivum immunologiae et therapiae experimentalis 2007;55(1):19-25.
2007: Brüne Bernhard; Zhou Jie
Hypoxia-inducible factor-1alpha under the control of nitric oxide.
Methods in enzymology 2007;435():463-78.
2006: Namgaladze Dmitry; Brüne Bernhard
Phospholipase A2-modified low-density lipoprotein activates the phosphatidylinositol 3-kinase-Akt pathway and increases cell survival in monocytic cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2510-6.
2006: Weigert Andreas; Johann Axel M; von Knethen Andreas; Schmidt Helmut; Geisslinger Gerd; Brüne Bernhard
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate.
Blood 2006;108(5):1635-42.
2006: Schnitzer S E; Schmid T; Zhou J; Brüne B
Hypoxia and HIF-1alpha protect A549 cells from drug-induced apoptosis.
Cell death and differentiation 2006;13(9):1611-3.
2006: Johann A M; von Knethen A; Lindemann D; Brüne B
Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst.
Cell death and differentiation 2006;13(9):1533-40.
2006: Köhl Roman; Preiss Stefan; von Knethen Andreas; Brüne Bernhard
Oxidized low-density lipoprotein depletes PKCalpha and attenuates reactive oxygen species formation in monocytes/macrophages.
Cardiovascular research 2006;71(3):574-85.
2006: Ulrich Sandra; Loitsch Stefan M; Rau Oliver; von Knethen Andreas; Brüne Bernhard; Schubert-Zsilavecz Manfred; Stein Jürgen M
Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism.
Cancer research 2006;66(14):7348-54.
2006: Zhou Jie; Brüne Bernhard
Cytokines and hormones in the regulation of hypoxia inducible factor-1alpha (HIF-1alpha).
Cardiovascular & hematological agents in medicinal chemistry 2006;4(3):189-97.
2006: Zhou Jie; Schmid Tobias; Schnitzer Steffen; Brüne Bernhard
Tumor hypoxia and cancer progression.
Cancer letters 2006;237(1):10-21.
2006: Köhl Roman; Zhou Jie; Brüne Bernhard
Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1alpha stabilization.
Free radical biology & medicine 2006;40(8):1430-42.
2006: Zhou Jie; Köhl Roman; Herr Barbara; Frank Ronald; Brüne Bernhard
Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha.
Molecular biology of the cell 2006;17(4):1549-58.
2006: Soller Mathias; Tautenhahn Anja; Brüne Bernhard; Zacharowski Kai; John Stefan; Link Hartmut; von Knethen Andreas
Peroxisome proliferator-activated receptor gamma contributes to T lymphocyte apoptosis during sepsis.
Journal of leukocyte biology 2006;79(1):235-43.
2005: Callapina Melvin; Zhou Jie; Schmid Tobias; Köhl Roman; Brüne Bernhard
NO restores HIF-1alpha hydroxylation during hypoxia: role of reactive oxygen species.
Free radical biology & medicine 2005;39(7):925-36.
2005: Ulrich S; Wächtershäuser A; Loitsch S; von Knethen A; Brüne B; Stein J
Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation.
Experimental cell research 2005;310(1):196-204.
2005: von Knethen Andreas; Brüne Bernhard
PKC alpha depletion in RAW264.7 macrophages following microbial/IFNgamma stimulation is PC-PLC-mediated.
Antioxidants & redox signaling 2005;7(9-10):1217-22.
2005: Callapina Melvin; Zhou Jie; Schnitzer Steffen; Metzen Eric; Lohr Christian; Deitmer Joachim W; Brüne Bernhard
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron.
Experimental cell research 2005;306(1):274-84.
2005: von Knethen Andreas; Tautenhahn Anja; Link Hartmut; Lindemann Dirk; Brüne Bernhard
Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4960-5.
2005: Brüne Bernhard
The intimate relation between nitric oxide and superoxide in apoptosis and cell survival.
Antioxidants & redox signaling 2005;7(3-4):497-507.
2005: Zhou Jie; Brüne Bernhard
NO and transcriptional regulation: from signaling to death.
Toxicology 2005;208(2):223-33.
2005: Budde Andreja; Schneiderhan-Marra Nicole; Petersen Gabriele; Brüne Bernhard
Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1).
Oncogene 2005;24(10):1802-8.
2005: Schnitzer Steffen E; Schmid Tobias; Zhou Jie; Eisenbrand Gerhard; Brüne Bernhard
Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia.
FEBS letters 2005;579(2):529-33.
2004: Zhou Jie; Callapina Melvin; Goodall Gregory J; Brüne Bernhard
Functional integrity of nuclear factor kappaB, phosphatidylinositol 3'-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1alpha.
Cancer research 2004;64(24):9041-8.
2004: Zhou Jie; Schmid Tobias; Brüne Bernhard
HIF-1alpha and p53 as targets of NO in affecting cell proliferation, death and adaptation.
Current molecular medicine 2004;4(7):741-51.
2004: Schmid Tobias; Zhou Jie; Brüne Bernhard
HIF-1 and p53: communication of transcription factors under hypoxia.
Journal of cellular and molecular medicine 2004;8(4):423-31.
2004: Schmid Tobias; Zhou Jie; Köhl Roman; Brüne Bernhard
p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1).
The Biochemical journal 2004;380(Pt 1):289-95.
2004: Zhou Jie; Schmid Tobias; Frank Ronald; Brüne Bernhard
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.
The Journal of biological chemistry 2004;279(14):13506-13.
2003: Shatrov Vladimir A; Brüne Bernhard
Induced expression of manganese superoxide dismutase by non-toxic concentrations of oxidized low-density lipoprotein (oxLDL) protects against oxLDL-mediated cytotoxicity.
The Biochemical journal 2003;374(Pt 2):505-11.
2003: Metzen Eric; Zhou Jie; Jelkmann Wolfgang; Fandrey Joachim; Brüne Bernhard
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases.
Molecular biology of the cell 2003;14(8):3470-81.
2003: Brüne Bernhard
Nitric oxide: NO apoptosis or turning it ON?
Cell death and differentiation 2003;10(8):864-9.
2003: Zhou Jie; Schmid Tobias; Brüne Bernhard
Tumor necrosis factor-alpha causes accumulation of a ubiquitinated form of hypoxia inducible factor-1alpha through a nuclear factor-kappaB-dependent pathway.
Molecular biology of the cell 2003;14(6):2216-25.
2003: Shatrov Vladimir A; Sumbayev Vadim V; Zhou Jie; Brüne Bernhard
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms.
Blood 2003;101(12):4847-9.
2003: Schneiderhan Nicole; Budde Andreja; Zhang Yanping; Brüne Bernhard
Nitric oxide induces phosphorylation of p53 and impairs nuclear export.
Oncogene 2003;22(19):2857-68.
2003: Tautenhahn Anja; Brüne Bernhard; von Knethen Andreas
Activation-induced PPARgamma expression sensitizes primary human T cells toward apoptosis.
Journal of leukocyte biology 2003;73(5):665-72.
2003: Brüne Bernhard; Zhou Jie; von Knethen Andreas
Nitric oxide, oxidative stress, and apoptosis.
Kidney international. Supplement 2003;(84):S22-4.
2003: Brüne Bernhard; Zhou Jie
The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha).
Current medicinal chemistry 2003;10(10):845-55.
2003: Zech Birgit; Köhl Roman; von Knethen Andreas; Brüne Bernhard
Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases.
The Biochemical journal 2003;371(Pt 3):1055-64.
2003: Brüne Bernhard; Schneiderhan Nicole
Nitric oxide evoked p53-accumulation and apoptosis.
Toxicology letters 2003;139(2-3):119-23.
2003: Zhou Jie; Fandrey Joachim; Schümann Jens; Tiegs Gisa; Brüne Bernhard
NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells.
American journal of physiology. Cell physiology 2003;284(2):C439-46.
2003: Sumbayev Vadim V; Budde Andreja; Zhou Jie; Brüne Bernhard
HIF-1 alpha protein as a target for S-nitrosation.
FEBS letters 2003;535(1-3):106-12.
2003: von Knethen Andreas; Brüne Bernhard
PPARgamma--an important regulator of monocyte/macrophage function.
Archivum immunologiae et therapiae experimentalis 2003;51(4):219-26.
2002: Von Knethen Andreas; Brüne Bernhard
Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2619-26.
2002: Sumbayev Vadim V; Sandau Katrin B; Brüne Bernhard
Mesangial cells but not hepatocytes are protected against NO/O(2)(-) cogeneration: mechanistic considerations.
European journal of pharmacology 2002;444(1-2):1-11.
2002: Dötsch Jörg; Schoof Ellen; Schöcklmann Harald O; Brüne Bernhard; Knerr Ina; Repp Reinald; Rascher Wolfgang
Nitric oxide increases adrenomedullin receptor function in rat mesangial cells.
Kidney international 2002;61(5):1707-13.
2002: Fischer Barbara; von Knethen Andreas; Brüne Bernhard
Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-gamma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2828-34.
2002: Klein Sabine D; Brüne Bernhard
Heat-shock protein 70 attenuates nitric oxide-induced apoptosis in RAW macrophages by preventing cytochrome c release.
The Biochemical journal 2002;362(Pt 3):635-41.
2002: Brüne Bernhard
Nitric oxide and apoptosis in mesangial cells.
Kidney international 2002;61(3):786-9.
2002: Brüne Bernhard; von Knethen Andreas
The role of nitric oxide and cyclooxygenase-2 in attenuating apoptosis.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2002;21(2):103-12.
2001: Sandau K B; Gantner F; Brüne B
Nitric oxide-induced F-actin disassembly is mediated via cGMP, cAMP, and protein kinase A activation in rat mesangial cells.
Experimental cell research 2001;271(2):329-36.
2001: Sandau K B; Zhou J; Kietzmann T; Brüne B
Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide.
The Journal of biological chemistry 2001;276(43):39805-11.
2001: Wolf D; Schümann J; Koerber K; Kiemer A K; Vollmar A M; Sass G; Papadopoulos T; Bang R; Klein S D; Brüne B; Tiegs G
Low-molecular-weight hyaluronic acid induces nuclear factor-kappaB-dependent resistance against tumor necrosis factor alpha-mediated liver injury in mice.
Hepatology (Baltimore, Md.) 2001;34(3):535-47.
2001: Brüne B; von Knethen A; Sandau K B
Transcription factors p53 and HIF-1alpha as targets of nitric oxide.
Cellular signalling 2001;13(8):525-33.
2001: Brüne B; Mohr S
Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase and caspase-3 by nitric oxide.
Current protein & peptide science 2001;2(1):61-72.
2001: Sandau K B; Fandrey J; Brüne B
Accumulation of HIF-1alpha under the influence of nitric oxide.
Blood 2001;97(4):1009-15.
2001: Von Knethen A A; Brüne B
Delayed activation of PPARgamma by LPS and IFN-gamma attenuates the oxidative burst in macrophages.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(2):535-44.
2000: Yang F; von Knethen A; Brüne B
Modulation of nitric oxide-evoked apoptosis by the p53-downstream target p21(WAF1/CIP1).
Journal of leukocyte biology 2000;68(6):916-22.
2000: Sandau K B; Faus H G; Brüne B
Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway.
Biochemical and biophysical research communications 2000;278(1):263-7.
2000: Brüne B; Cantoni O
Nitric oxide-mediated redox reactions in pathology, biochemistry and medicine.
Cell death and differentiation 2000;7(10):1018-20.
2000: Sandau K B; Brüne B
Molecular actions of nitric oxide in mesangial cells.
Histology and histopathology 2000;15(4):1151-8.
2000: von Knethen A; Brüne B
Attenuation of macrophage apoptosis by the cAMP-signaling system.
Molecular and cellular biochemistry 2000;212(1-2):35-43.
2000: von Knethen A; Brüne B
Superinduction of cyclooxygenase-2 by NO(*) and agonist challenge involves transcriptional regulation mediated by AP-1 activation.
Biochemistry 2000;39(6):1532-40.
2000: Sandau K B; Brüne B
Up-regulation of Bcl-2 by redox signals in glomerular mesangial cells.
Cell death and differentiation 2000;7(1):118-25.
1999: Brockhaus F; Brüne B
p53 accumulation in apoptotic macrophages is an energy demanding process that precedes cytochrome c release in response to nitric oxide.
Oncogene 1999;18(47):6403-10.
1999: von Knethen A; Brockhaus F; Kleiter I; Brüne B
NO-Evoked macrophage apoptosis is attenuated by cAMP-induced gene expression.
Molecular medicine (Cambridge, Mass.) 1999;5(10):672-84.
1999: Brüne B; von Knethen A; Sandau K B
Nitric oxide (NO): an effector of apoptosis.
Cell death and differentiation 1999;6(10):969-75.
1999: Sandau K B; Callsen D; Brüne B
Protection against nitric oxide-induced apoptosis in rat mesangial cells demands mitogen-activated protein kinases and reduced glutathione.
Molecular pharmacology 1999;56(4):744-51.
1999: von Knethen A; Callsen D; Brüne B
Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2858-66.
1999: Zech B; Wilm M; van Eldik R; Brüne B
Mass spectrometric analysis of nitric oxide-modified caspase-3.
The Journal of biological chemistry 1999;274(30):20931-6.
1999: Glockzin S; von Knethen A; Scheffner M; Brüne B
Activation of the cell death program by nitric oxide involves inhibition of the proteasome.
The Journal of biological chemistry 1999;274(28):19581-6.
1999: Callsen D; Sandau K B; Brüne B
Nitric oxide and superoxide inhibit platelet-derived growth factor receptor phosphotyrosine phosphatases.
Free radical biology & medicine 1999;26(11-12):1544-53.
1999: Mohr S; Hallak H; de Boitte A; Lapetina E G; Brüne B
Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase.
The Journal of biological chemistry 1999;274(14):9427-30.
1999: Brockhaus F; Brüne B
Overexpression of CuZn superoxide dismutase protects RAW 264.7 macrophages against nitric oxide cytotoxicity.
The Biochemical journal 1999;338 ( Pt 2)():295-303.
1999: Callsen D; Brüne B
Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis.
Biochemistry 1999;38(8):2279-86.
1999: von Knethen A; Callsen D; Brüne B
NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages.
Molecular biology of the cell 1999;10(2):361-72.
1998: Schulze-Lohoff E; Hugo C; Rost S; Arnold S; Gruber A; Brüne B; Sterzel R B
Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z/P2X7 receptors.
The American journal of physiology 1998;275(6 Pt 2):F962-71.
1998: Callsen D; Pfeilschifter J; Brüne B
Rapid and delayed p42/p44 mitogen-activated protein kinase activation by nitric oxide: the role of cyclic GMP and tyrosine phosphatase inhibition.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4852-8.
1998: Brüne B; Sandau K; von Knethen A
Apoptotic cell death and nitric oxide: activating and antagonistic transducing pathways.
Biochemistry. Biokhimii?a 1998;63(7):817-25.
1998: von Knethen A; Lotero A; Brüne B
Etoposide and cisplatin induced apoptosis in activated RAW 264.7 macrophages is attenuated by cAMP-induced gene expression.
Oncogene 1998;17(3):387-94.
1998: Brüne B; von Knethen A; Sandau K B
Nitric oxide and its role in apoptosis.
European journal of pharmacology 1998;351(3):261-72.
1998: Messmer U K; Reimer D M; Brüne B
Protease activation during nitric oxide-induced apoptosis: comparison between poly(ADP-ribose) polymerase and U1-70kDa cleavage.
European journal of pharmacology 1998;349(2-3):333-43.
1998: Sandau K; Pfeilschifter J; Brüne B
Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cells.
European journal of pharmacology 1998;342(1):77-84.
1998: Brockhaus F; Brüne B
U937 apoptotic cell death by nitric oxide: Bcl-2 downregulation and caspase activation.
Experimental cell research 1998;238(1):33-41.
1997: Mohr S; Zech B; Lapetina E G; Brüne B
Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide.
Biochemical and biophysical research communications 1997;238(2):387-91.
1997: von Knethen A; Brüne B
Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997;11(11):887-95.
1997: Sandau K; Pfeilschifter J; Brüne B
Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis.
Kidney international 1997;52(2):378-86.
1997: Messmer U K; Brüne B
Attenuation of p53 expression and Bax down-regulation during phorbol ester mediated inhibition of apoptosis.
British journal of pharmacology 1997;121(4):625-34.
1997: Sandau K; Pfeilschifter J; Brüne B
The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4938-46.
1997: Brüne B; Götz C; Messmer U K; Sandau K; Hirvonen M R; Lapetina E G
Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis.
The Journal of biological chemistry 1997;272(11):7253-8.
1996: Mühl H; Sandau K; Brüne B; Briner V A; Pfeilschifter J
Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells.
European journal of pharmacology 1996;317(1):137-49.
1996: Brüne B; Gölkel C; von Knethen A
Cytokine and low-level nitric oxide prestimulation block p53 accumulation and apoptosis of RAW 264.7 macrophages.
Biochemical and biophysical research communications 1996;229(2):396-401.
1996: Messmer U K; Brüne B
Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways.
The Biochemical journal 1996;319 ( Pt 1)():299-305.
1996: Messmer U K; Reed U K; Brüne B
Bcl-2 protects macrophages from nitric oxide-induced apoptosis.
The Journal of biological chemistry 1996;271(33):20192-7.
1996: Hirvonen M R; Brüne B; Lapetina E G
Heat shock proteins and macrophage resistance to the toxic effects of nitric oxide.
The Biochemical journal 1996;315 ( Pt 3)():845-9.
1996: Messmer U K; Brüne B
Modification of macrophage glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide.
European journal of pharmacology 1996;302(1-3):171-82.
1996: Messmer U K; Reimer D M; Reed J C; Brüne B
Nitric oxide induced poly(ADP-ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl-2.
FEBS letters 1996;384(2):162-6.
1996: Sandau K; Brüne B
The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis.
Cellular signalling 1996;8(3):173-7.
1996: Messmer U K; Brüne B
Nitric oxide (NO) in apoptotic versus necrotic RAW 264.7 macrophage cell death: the role of NO-donor exposure, NAD+ content, and p53 accumulation.
Archives of biochemistry and biophysics 1996;327(1):1-10.
1996: Mühl H; Nitsch D; Sandau K; Brüne B; Varga Z; Pfeilschifter J
Apoptosis is triggered by the cyclic AMP signalling pathway in renal mesangial cells.
FEBS letters 1996;382(3):271-5.
1996: Mohr S; Stamler J S; Brüne B
Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment.
The Journal of biological chemistry 1996;271(8):4209-14.
1996: Brüne B; Lapetina E G
Nitric oxide-induced covalent modification of glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase.
Methods in enzymology 1996;269():400-7.
1996: Brüne B; Mohr S; Messmer U K
Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways.
Reviews of physiology, biochemistry and pharmacology 1996;127():1-30.
1995: Brüne B; Messmer U K; Sandau K
The role of nitric oxide in cell injury.
Toxicology letters 1995;82-83():233-7.
1995: Messmer U K; Lapetina E G; Brüne B
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds.
Molecular pharmacology 1995;47(4):757-65.
1995: Brüne B; Lapetina E G
Glyceraldehyde-3-phosphate dehydrogenase: a target for nitric oxide signaling.
Advances in pharmacology (San Diego, Calif.) 1995;34():351-60.
1995: Brüne B; Lapetina E G
Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase as a target for nitric oxide signaling.
Genetic engineering 1995;17():149-64.
1994: Brüne B; von Appen F; Ullrich V
Receptor occupancy regulates Ca2+ entry and intracellular Ca2+ redistribution in activated human platelets.
The Biochemical journal 1994;304 ( Pt 3)():993-9.
1994: Messmer U K; Ankarcrona M; Nicotera P; Brüne B
p53 expression in nitric oxide-induced apoptosis.
FEBS letters 1994;355(1):23-6.
1994: Mohr S; Stamler J S; Brüne B
Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents.
FEBS letters 1994;348(3):223-7.
1994: Ankarcrona M; Dypbukt J M; Brüne B; Nicotera P
Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells.
Experimental cell research 1994;213(1):172-7.
1994: Dimmeler S; Messmer U K; Tiegs G; Brüne B
Modulation of glyceraldehyde-3-phosphate dehydrogenase in Salmonella abortus equi lipopolysaccharide-treated mice.
European journal of pharmacology 1994;267(1):105-12.
1994: Messmer U K; Brüne B
Modulation of inducible nitric oxide synthase in RINm5F cells.
Cellular signalling 1994;6(1):17-24.
1994: Brüne B; Dimmeler S; Molina y Vedia L; Lapetina E G
Nitric oxide: a signal for ADP-ribosylation of proteins.
Life sciences 1994;54(2):61-70.
1993: Brüne B; von Appen F; Ullrich V
Calcium homeostasis and eicosanoid formation in human platelets.
Prostaglandins, leukotrienes, and essential fatty acids 1993;48(4):277-89.
1993: Dimmeler S; Ankarcrona M; Nicotera P; Brüne B
Exogenous nitric oxide (NO) generation or IL-1 beta-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(7):2964-71.
1993: Wu X B; Brüne B; Von Appen F; Ullrich V
Efflux of cyclic GMP from activated human platelets.
Molecular pharmacology 1993;43(4):564-8.
1993: Dimmeler S; Brüne B
Nitric oxide preferentially stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase compared to alcohol or lactate dehydrogenase.
FEBS letters 1993;315(1):21-4.
1992: Molina y Vedia L; McDonald B; Reep B; Brüne B; Di Silvio M; Billiar T R; Lapetina E G
Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.
The Journal of biological chemistry 1992;267(35):24929-32.
1992: Dimmeler S; Brüne B
Characterization of a nitric-oxide-catalysed ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.
European journal of biochemistry / FEBS 1992;210(1):305-10.
1992: Dimmeler S; Lottspeich F; Brüne B
Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.
The Journal of biological chemistry 1992;267(24):16771-4.
1992: Brüne B; Ullrich V
Cyclic nucleotides and intracellular-calcium homeostasis in human platelets.
European journal of biochemistry / FEBS 1992;207(2):607-13.
1992: Wu X B; Brüne B; von Appen F; Ullrich V
Reversible activation of soluble guanylate cyclase by oxidizing agents.
Archives of biochemistry and biophysics 1992;294(1):75-82.
1992: Brüne B; Dimmeler S; Lapetina E G
NADPH: a stimulatory cofactor for nitric oxide-induced ADP-ribosylation reaction.
Biochemical and biophysical research communications 1992;182(3):1166-71.
1991: Brüne B; Lapetina E G
Phosphorylation of nitric oxide synthase by protein kinase A.
Biochemical and biophysical research communications 1991;181(2):921-6.
1991: Brüne B; Ullrich V
Different calcium pools in human platelets and their role in thromboxane A2 formation.
The Journal of biological chemistry 1991;266(29):19232-7.
1991: Dimmeler S; Brüne B
L-arginine stimulates an endogenous ADP-ribosyltransferase.
Biochemical and biophysical research communications 1991;178(3):848-55.
1991: Brüne B; Ullrich V
Calcium mobilization in human platelets by receptor agonists and calcium-ATPase inhibitors.
FEBS letters 1991;284(1):1-4.
1991: Brüne B; Ullrich V
12-hydroperoxyeicosatetraenoic acid inhibits main platelet functions by activation of soluble guanylate cyclase.
Molecular pharmacology 1991;39(5):671-8.
1990: Brüne B; Schmidt K U; Ullrich V
Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion.
European journal of biochemistry / FEBS 1990;192(3):683-8.
1990: Brüne B; Lapetina E G
Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase.
Archives of biochemistry and biophysics 1990;279(2):286-90.
1990: Brüne B; Molina y Vedia L; Lapetina E G
Agonist-induced ADP-ribosylation of a cytosolic protein in human platelets.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3304-8.
1989: Brüne B; Lapetina E G
Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents.
The Journal of biological chemistry 1989;264(15):8455-8.
1989: Hecker M; Brüne B; Decker K; Ullrich V
The sulfhydryl reagent thimerosal elicits human platelet aggregation by mobilization of intracellular calcium and secondary prostaglandin endoperoxide formation.
Biochemical and biophysical research communications 1989;159(3):961-8.
1989: Ullrich V; Brüne B; Hecker G; Schmidt K U; Mülsch A; Busse R
Physiological targets of superoxide anion and hydrogen peroxide in reperfusion injury.
Free radical research communications 1989;7(3-6):265-74.
1987: Brüne B; Ullrich V
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.
Molecular pharmacology 1987;32(4):497-504.

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