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James MacGregor

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Harper Susan B; Dertinger Stephen D; Bishop Michelle E; Lynch Anthony M; Lorenzo Maria; Saylor Michelle; MacGregor James T
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog.
Kissling Grace E; Dertinger Stephen D; Hayashi Makoto; MacGregor James T
Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability.
Thybaud Véronique; Aardema Marilyn; Casciano Daniel; Dellarco Vicki; Embry Michelle R; Gollapudi B Bhaskar; Hayashi Makoto; Holsapple Michael P; Jacobson-Kram David; Kasper Peter; MacGregor James T; Rees Robert
Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.

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2007: Harper Susan B; Dertinger Stephen D; Bishop Michelle E; Lynch Anthony M; Lorenzo Maria; Saylor Michelle; MacGregor James T
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(2):406-14.
2007: Kissling Grace E; Dertinger Stephen D; Hayashi Makoto; MacGregor James T
Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability.
Mutation research 2007;634(1-2):235-40.
2007: Thybaud Véronique; Aardema Marilyn; Casciano Daniel; Dellarco Vicki; Embry Michelle R; Gollapudi B Bhaskar; Hayashi Makoto; Holsapple Michael P; Jacobson-Kram David; Kasper Peter; MacGregor James T; Rees Robert
Relevance and follow-up of positive results in in vitro genetic toxicity assays: an ILSI-HESI initiative.
Mutation research 2007;633(2):67-79.
2007: Hayashi Makoto; MacGregor James T; Gatehouse David G; Blakey David H; Dertinger Stephen D; Abramsson-Zetterberg Lilianne; Krishna Gopala; Morita Takeshi; Russo Antonella; Asano Norihide; Suzuki Hiroshi; Ohyama Wakako; Gibson Dave;
In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.
Mutation research 2007;627(1):10-30.
2007: Kirkland D J; Hayashi M; Jacobson-Kram D; Kasper P; MacGregor J T; Müller L; Uno Y
Summary of major conclusions from the 4th IWGT, San Francisco, 9-10 September, 2005.
Mutation research 2007;627(1):5-9.
2007: Kirkland D J; Hayashi M; Jacobson-Kram D; Kasper P; MacGregor J T; Müller L; Uno Y
The International Workshops on Genotoxicity Testing (IWGT): history and achievements.
Mutation research 2007;627(1):1-4.
2007: Thybaud V; Aardema M; Clements J; Dearfield K; Galloway S; Hayashi M; Jacobson-Kram D; Kirkland D; MacGregor J T; Marzin D; Ohyama W; Schuler M; Suzuki H; Zeiger E;
Strategy for genotoxicity testing: hazard identification and risk assessment in relation to in vitro testing.
Mutation research 2007;627(1):41-58.
2006: MacGregor James T; Bishop Michelle E; McNamee James P; Hayashi Makoto; Asano Norhide; Wakata Akihiro; Nakajima Madoka; Saito Junichiro; Aidoo Anane; Moore Martha M; Dertinger Stephen D
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(1):92-107.
2006: Dertinger Stephen D; Bishop Michelle E; McNamee James P; Hayashi Makoto; Suzuki Takayoshi; Asano Norihide; Nakajima Madoka; Saito Junichiro; Moore Martha; Torous Dorothea K; Macgregor James T
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(1):83-91.
2005: Akerman Gregory S; Rosenzweig Barry A; Domon Olen E; Tsai Chen-An; Bishop Michelle E; McGarrity Lynda J; Macgregor James T; Sistare Frank D; Chen James J; Morris Suzanne M
Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells.
Environmental and molecular mutagenesis 2005;45(2-3):188-205.
2004: Akerman G S; Rosenzweig B A; Domon O E; McGarrity L J; Blankenship L R; Tsai C A; Culp S J; MacGregor J T; Sistare F D; Chen J J; Morris S M
Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells.
Mutation research 2004;549(1-2):43-64.
2004: MacGregor James T
Biomarkers of cancer risk and therapeutic benefit: new technologies, new opportunities, and some challenges.
Toxicologic pathology 2004;32 Suppl 1():99-105.
2004: Wallace Kendall B; Hausner Elizabeth; Herman Eugene; Holt Gordon D; MacGregor James T; Metz Alan L; Murphy Elizabeth; Rosenblum I Y; Sistare Frank D; York Malcolm J
Serum troponins as biomarkers of drug-induced cardiac toxicity.
Toxicologic pathology 2004;32(1):106-21.
2004: Dertinger Stephen D; Camphausen Kevin; Macgregor James T; Bishop Michelle E; Torous Dorothea K; Avlasevich Svetlana; Cairns Siân; Tometsko Carol R; Menard Cynthia; Muanza Thierry; Chen Yuhchyau; Miller Richard K; Cederbrant Karin; Sandelin Kerstin; Pontén Ingrid; Bolcsfoldi George
Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.
Environmental and molecular mutagenesis 2004;44(5):427-35.
2003: Müller Lutz; Blakey David; Dearfield Kerry L; Galloway Sheila; Guzzie Peggy; Hayashi Makoto; Kasper Peter; Kirkland David; MacGregor James T; Parry James M; Schechtman Leonard; Smith Andrew; Tanaka Noriho; Tweats David; Yamasaki Hiroshi;
Strategy for genotoxicity testing and stratification of genotoxicity test results--report on initial activities of the IWGT Expert Group.
Mutation research 2003;540(2):177-81.
2003: Kirkland D J; Hayashi M; MacGregor J T; Müller L; Schechtman L M; Sofuni T
Summary of major conclusions.
Mutation research 2003;540(2):123-5.
2003: MacGregor James T
The future of regulatory toxicology: impact of the biotechnology revolution.
Toxicological sciences : an official journal of the Society of Toxicology 2003;75(2):236-48.
2003: MacGregor James T
SNPs and chips: genomic data in safety evaluation and risk assessment.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):207-8.
2002: Freund Yvonne R; Dabbs Jack; Creek Moire R; Phillips Sandra J; Tyson Charles A; MacGregor James T
Synergistic bone marrow toxicity of pyrimethamine and zidovudine in murine in vivo and in vitro models: mechanism of toxicity.
Toxicology and applied pharmacology 2002;181(1):16-26.
2002: Aardema Marilyn J; MacGregor James T
Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies.
Mutation research 2002;499(1):13-25.
2001: Freund Y R; Dousman L; Riccio E S; Sato B; MacGregor J T; Mohagheghpour N
Immunohematotoxicity studies with combinations of dapsone and zidovudine.
International immunopharmacology 2001;1(12):2131-41.
2001: MacGregor J T; Collins J M; Sugiyama Y; Tyson C A; Dean J; Smith L; Andersen M; Curren R D; Houston J B; Kadlubar F F; Kedderis G L; Krishnan K; Li A P; Parchment R E; Thummel K; Tomaszewski J E; Ulrich R; Vickers A E; Wrighton S A
In vitro human tissue models in risk assessment: report of a consensus-building workshop.
Toxicological sciences : an official journal of the Society of Toxicology 2001;59(1):17-36.
2000: MacGregor J T; Casciano D; Müller L
Strategies and testing methods for identifying mutagenic risks.
Mutation research 2000;455(1-2):3-20.
2000: Freund Y R; Dousman L; MacGregor J T; Mohagheghpour N
Oral treatment with trimethoprim-sulfamethoxazole and zidovudine suppresses murine accessory cell-dependent immune responses.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(2):335-42.
2000: Witt K L; Knapton A; Wehr C M; Hook G J; Mirsalis J; Shelby M D; MacGregor J T
Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program.
Environmental and molecular mutagenesis 2000;36(3):163-94.
2000: Hayashi M; MacGregor J T; Gatehouse D G; Adler I D; Blakey D H; Dertinger S D; Krishna G; Morita T; Russo A; Sutou S
In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring.
Environmental and molecular mutagenesis 2000;35(3):234-52.
2000: Kirkland D J; Hayashi M; MacGregor J T; Müller L; Schechtman L; Sofuni T
Summary of major conclusions from the International Workshop on Genotoxicity Test Procedures.
Environmental and molecular mutagenesis 2000;35(3):162-6.
1998: Freund Y R; Riccio E S; Phillips S J; Dousman L; MacGregor J T
Pyrimethamine impairs host resistance to infection with Listeria monocytogenes in BALB/c mice.
Toxicological sciences : an official journal of the Society of Toxicology 1998;42(2):91-8.
1998: MacGregor J T
Transgenic animal models for mutagenesis studies: role in mutagenesis research and regulatory testing.
Environmental and molecular mutagenesis 1998;32(2):106-9.
1997: MacGregor J T; Wehr C M; Hiatt R A; Peters B; Tucker J D; Langlois R G; Jacob R A; Jensen R H; Yager J W; Shigenaga M K; Frei B; Eynon B P; Ames B N
'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status.
Mutation research 1997;377(1):125-35.
1997: Blount B C; Mack M M; Wehr C M; MacGregor J T; Hiatt R A; Wang G; Wickramasinghe S N; Everson R B; Ames B N
Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3290-5.
1996: Winegar R A; Monforte J A; Suing K D; O'Loughlin K G; Rudd C J; Macgregor J T
Determination of tissue distribution of an intramuscular plasmid vaccine using PCR and in situ DNA hybridization.
Human gene therapy 1996;7(17):2185-94.
1995: MacGregor J T; Farr S; Tucker J D; Heddle J A; Tice R R; Turteltaub K W
New molecular endpoints and methods for routine toxicity testing.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1995;26(2):156-73.
1995: MacGregor J T; Tucker J D; Eastmond D A; Wyrobek A J
Integration of cytogenetic assays with toxicology studies.
Environmental and molecular mutagenesis 1995;25(4):328-37.
1994: Tice R R; Hayashi M; MacGregor J T; Anderson D; Blakey D H; Holden H E; Kirsch-Volders M; Oleson F B; Pacchierotti F; Preston R J
Report from the working group on the in vivo mammalian bone marrow chromosomal aberration test.
Mutation research 1994;312(3):305-12.
1994: Hayashi M; Tice R R; MacGregor J T; Anderson D; Blakey D H; Kirsh-Volders M; Oleson F B; Pacchierotti F; Romagna F; Shimada H
In vivo rodent erythrocyte micronucleus assay.
Mutation research 1994;312(3):293-304.
1994: MacGregor J T
Environmental mutagenesis: past and future directions.
Environmental and molecular mutagenesis 1994;23 Suppl 24():73-7.
1993: Mirsalis J C; Provost G S; Matthews C D; Hamner R T; Schindler J E; O'Loughlin K G; MacGregor J T; Short J M
Induction of hepatic mutations in lacI transgenic mice.
Mutagenesis 1993;8(3):265-71.
1991: MacGregor J T
Micronucleus assay protocols.
Mutation research 1991;259(1):123-5.
1991: Heddle J A; Cimino M C; Hayashi M; Romagna F; Shelby M D; Tucker J D; Vanparys P; MacGregor J T
Micronuclei as an index of cytogenetic damage: past, present, and future.
Environmental and molecular mutagenesis 1991;18(4):277-91.
1990: MacGregor J T; Schlegel R; Wehr C M; Alperin P; Ames B N
Cytogenetic damage induced by folate deficiency in mice is enhanced by caffeine.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9962-5.
1990: Bishop J B; Witt K L; Gulati D K; MacGregor J T
Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP).
Mutagenesis 1990;5(6):549-54.
1990: Smith D F; MacGregor J T; Hiatt R A; Hooper N K; Wehr C M; Peters B; Goldman L R; Yuan L A; Smith P A; Becker C E
Micronucleated erythrocytes as an index of cytogenetic damage in humans: demographic and dietary factors associated with micronucleated erythrocytes in splenectomized subjects.
Cancer research 1990;50(16):5049-54.
1990: Sabourin P J; Sun J D; MacGregor J T; Wehr C M; Birnbaum L S; Lucier G; Henderson R F
Effect of repeated benzene inhalation exposures on benzene metabolism, binding to hemoglobin, and induction of micronuclei.
Toxicology and applied pharmacology 1990;103(3):452-62.
1990: MacGregor J T; Wehr C M; Henika P R; Shelby M D
The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1990;14(3):513-22.
1990: MacGregor J T
Dietary factors affecting spontaneous chromosomal damage in man.
Progress in clinical and biological research 1990;347():139-53.
1989: MacGregor J T; Tucker J D; Ziderman I I; Wehr C M; Wilson R E; Friedman M
Non-clastogenicity in mouse bone marrow of fructose/lysine and other sugar/amino acid browning products with in vitro genotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1989;27(11):715-21.
1989: MacGregor J T; Henika P R; Whitehand L; Wehr C M
The fetal blood erythrocyte micronucleus assay: classification of RNA-positive erythrocytes into two age populations by RNA aggregation state.
Mutagenesis 1989;4(3):190-9.
1989: McFee A F; Jauhar P P; Lowe K W; MacGregor J T; Wehr C M
Assays of three carcinogen/non-carcinogen chemical pairs for in vivo induction of chromosome aberrations, sister chromatid exchanges and micronuclei.
Environmental and molecular mutagenesis 1989;14(4):207-20.
1988: Jauhar P P; Henika P R; MacGregor J T; Wehr C M; Shelby M D; Murphy S A; Margolin B H
1,3-Butadiene: induction of micronucleated erythrocytes in the peripheral blood of B6C3F1 mice exposed by inhalation for 13 weeks.
Mutation research 1988;209(3-4):171-6.
1988: Everson R B; Wehr C M; Erexson G L; MacGregor J T
Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes.
Journal of the National Cancer Institute 1988;80(7):525-9.
1988: MacGregor J T; Wilson R E
Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency.
Environmental and molecular mutagenesis 1988;11(3):315-22.
1987: MacGregor J T; Heddle J A; Hite M; Margolin B H; Ramel C; Salamone M F; Tice R R; Wild D
Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes.
Mutation research 1987;189(2):103-12.
1987: Paulson G D; Feil V J; MacGregor J T
Formation of a diazonium cation intermediate in the metabolism of sulphamethazine to desaminosulphamethazine in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(6):697-707.
1986: Schlegel R; MacGregor J T; Everson R B
Assessment of cytogenetic damage by quantitation of micronuclei in human peripheral blood erythrocytes.
Cancer research 1986;46(7):3717-21.
1986: MacGregor J T
Mutagenic and carcinogenic effects of flavonoids.
Progress in clinical and biological research 1986;213():411-24.
1986: Hatch F T; MacGregor J T; Zeiger E
Review: Putative mutagens and carcinogens in food. VII. Genetic toxicology of the diet. A summary of a satellite symposium of the Fourth International Conference on Environmental Mutagens. Copenhagen, June 19-22, 1985. Abstracts.
Environmental mutagenesis 1986;8(3):467-84.
1986: MacGregor J T
Genetic toxicology of dietary flavonoids.
Progress in clinical and biological research 1986;206():33-43.
1985: MacGregor J T; Wilson R E; Neff W E; Frankel E N
Mutagenicity tests of lipid oxidation products in Salmonella typhimurium: monohydroperoxides and secondary oxidation products of methyl linoleate and methyl linolenate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1985;23(12):1041-7.
1985: Choy W N; MacGregor J T; Shelby M D; Maronpot R R
Induction of micronuclei by benzene in B6C3F1 mice: retrospective analysis of peripheral blood smears from the NTP carcinogenesis bioassay.
Mutation research 1985;143(1-2):55-9.
1984: Schlegel R; MacGregor J T
The persistence of micronucleated erythrocytes in the peripheral circulation of normal and splenectomized Fischer 344 rats: implications for cytogenetic screening.
Mutation research 1984;127(2):169-74.
1984: Choy W N; MacGregor J T
Density-gradient enrichment of newly-formed mouse erythrocytes. Application to the micronucleus test.
Mutation research 1984;130(3):159-64.
1984: Elliger C A; Henika P R; MacGregor J T
Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships.
Mutation research 1984;135(2):77-86.
1984: MacGregor J T
Genetic and carcinogenic effects of plant flavonoids: an overview.
Advances in experimental medicine and biology 1984;177():497-526.
1983: MacGregor J T; Wehr C M; Manners G D; Jurd L; Minkler J L; Carrano A V
In vivo exposure to plant flavonols. Influence on frequencies of micronuclei in mouse erythrocytes and sister-chromatid exchange in rabbit lymphocytes.
Mutation research 1983;124(3-4):255-70.
1983: Schlegel R; MacGregor J T
A rapid screen for cumulative chromosomal damage in mice. Accumulation of circulating micronucleated erythrocytes.
Mutation research 1983;113(6):481-7.
1983: Heddle J A; Hite M; Kirkhart B; Mavournin K; MacGregor J T; Newell G W; Salamone M F
The induction of micronuclei as a measure of genotoxicity. A report of the U.S. Environmental Protection Agency Gene-Tox Program.
Mutation research 1983;123(1):61-118.
1983: MacGregor J T; Wehr C M; Langlois R G
A simple fluorescent staining procedure for micronuclei and RNA in erythrocytes using Hoechst 33258 and pyronin Y.
Mutation research 1983;120(4):269-75.
1983: Gardner H W; Crawford C G; MacGregor J T
Negative Ames tests of epoxide fatty methyl esters derived from hemolysis of linoleic acid hydroperoxides.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1983;21(2):175-80.
1983: Carver J H; Carrano A V; MacGregor J T
Genetic effects of the flavonols quercetin, kaempferol, and galangin on Chinese hamster ovary cells in vitro.
Mutation research 1983;113(1):45-60.
1983: MacGregor J T; Schlegel R; Choy W N; Wehr C M
Micronuclei in circulating erythrocytes: a rapid screen for chromosomal damage during routine toxicity testing in mice.
Developments in toxicology and environmental science 1983;11():555-8.
1982: Friedman M; Wehr C M; Schade J E; MacGregor J T
Inactivation of aflatoxin B1 mutagenicity by thiols.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1982;20(6):887-92.
1982: Sacks L E; MacGregor J T
The B. subtilis multigene sporulation test for mutagens: detection of mutagens inactive in the Salmonella his reversion test.
Mutation research 1982;95(2-3):191-202.
1982: Schlegel R; MacGregor J T
The persistence of micronuclei in peripheral blood erythrocytes: detection of chronic chromosome breakage in mice.
Mutation research 1982;104(6):367-9.
1981: Meltz M L; MacGregor J T
Activity of the plant flavanol quercetin in the mouse lymphoma L5178Y TK+/- mutation, DNA single-strand break, and Balb/c 3T3 chemical transformation assays.
Mutation research 1981;88(3):317-24.
1980: Ivie G W; Macgregor J T; Hammock B D
Mutagenicity of psoralen epoxides.
Mutation research 1980;79(1):73-7.
1980: Karayiannis N I; MacGregor J T; Bjeldanes L F
Biological effects of alkali-treated soya protein and lactalbumin in the rat and mouse.
Food and cosmetics toxicology 1980;18(3):333-46.
1980: MacGregor J T; Diamond M J; Mazzeno L W; Friedman M
Mutagenicity tests of fabric-finishing agents in Salmonella typhimurium: fiber-reactive wool dyes and cotton flame retardants.
Environmental mutagenesis 1980;2(3):405-18.
1980: MacGregor J T; Wehr C M; Gould D H
Clastogen-induced micronuclei in peripheral blood erythrocytes: the basis of an improved micronucleus test.
Environmental mutagenesis 1980;2(4):509-14.

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