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Kay Brune

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Benito de Celis Alonso; Kay Brune; Marina Sergeyeva; Andreas Hess
Lateralization of responses to vibrissal stimulation: connectivity and information integration in the rat sensory-motor cortex assessed with fMRI.
Burkhard Hinz; Kay Brune
Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
Andreas Hess; Roland Axmann; Juergen Rech; Stefanie Finzel; Cornelia Heindl; Silke Kreitz; Marina Sergeeva; Marc Saake; Meritxell Garcia; george kollias; Rainer H Straub; Olaf Sporns; Arnd Doerfler; Kay Brune; Georg Schett
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system.

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All Publications

2012: Benito de Celis Alonso; Kay Brune; Marina Sergeyeva; Andreas Hess
Lateralization of responses to vibrissal stimulation: connectivity and information integration in the rat sensory-motor cortex assessed with fMRI.
NeuroImage 2012;62(3):2101-9.
2012: Burkhard Hinz; Kay Brune
Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
Annals of the rheumatic diseases 2012;71(1):20-5.
2011: Andreas Hess; Roland Axmann; Juergen Rech; Stefanie Finzel; Cornelia Heindl; Silke Kreitz; Marina Sergeeva; Marc Saake; Meritxell Garcia; george kollias; Rainer H Straub; Olaf Sporns; Arnd Doerfler; Kay Brune; Georg Schett
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(9):3731-6.
2010: Kay Brune; Bertold Renner; Burkhard Hinz
Using pharmacokinetic principles to optimize pain therapy.
Nature reviews. Rheumatology 2010;6(10):589-98.
2010: Kay Brune; Thomas Stammschulte
[Transdermal fentanyl: what if doctor and pharmacist fail?].
MMW Fortschritte der Medizin 2010;152(15):41, 43.
2010: Bertold Renner; Josef Zacher; Asokumar Buvanendran; Gerrit Walter; Jochen Strauss; Kay Brune
Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.
Naunyn-Schmiedeberg's archives of pharmacology 2010;381(2):127-36.
2010: Kathrin Mandery; Krystyna Bujok; Ingrid Schmidt; Thomas Wex; Gerhard Treiber; Peter Malfertheiner; Tilman T Rau; Kerstin U Amann; Kay Brune; Martin F Fromm; Hartmut Glaeser
Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa.
The Journal of pharmacology and experimental therapeutics 2010;332(2):345-51.
2010: Cornelia Heindl-Erdmann; Roland Axmann; Silke Kreitz; Jochen Zwerina; Josef Penninger; Georg Schett; Kay Brune; Andreas Hess
Combining functional magnetic resonance imaging with mouse genomics: new options in pain research.
Neuroreport 2010;21(1):29-33.
2009: Bertold Renner; Kay Brune
Are myocardial infarctions and death in healthy individuals associated with the use of cyclooxygenase inhibitors?
Clinical pharmacology and therapeutics 2009;86(6):599-600; author reply 602-4.
2009: Kay Brune; Bertold Renner; R Maas
[Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous].
Deutsche medizinische Wochenschrift (1946) 2009;134(36):1771-3.
2009: Kay Brune; Burkhard Hinz; Ivan Otterness
Aspirin and acetaminophen: should they be available over the counter?
Current rheumatology reports 2009;11(1):36-40.
2009: Y Zopf; C Rabe; Antje Neubert; C Janson; Kay Brune; Eckhart Hahn; Harald Dormann
Gender-based differences in drug prescription: relation to adverse drug reactions.
Pharmacology 2009;84(6):333-9.
2008: Y Zopf; Christina Rabe; Antje Neubert; Karl G Gassmann; Wolfgang Rascher; Eckhart Hahn; Kay Brune; Harald Dormann
Women encounter ADRs more often than do men.
European journal of clinical pharmacology 2008;64(10):999-1004.
2008: Burkhard Hinz; Kay Brune
Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology.
Trends in pharmacological sciences 2008;29(8):391-7.
2008: Kay Brune; Hugo A Katus; Joachim Moecks; Eberhard Spanuth; Allan S Jaffe; Evangelos Giannitsis
N-terminal pro-B-type natriuretic peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trial.
Clinical chemistry 2008;54(7):1149-57.
2008: Burkhard Hinz; Olga Cheremina; D Besz; S Zlotnick; Kay Brune
Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers.
International journal of clinical pharmacology and therapeutics 2008;46(4):180-6.
2008: Burkhard Hinz; Olga Cheremina; Kay Brune
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):383-90.
2008: Julia Knabl; Robert Witschi; Katharina Hösl; Heiko Reinold; Ulrike B Zeilhofer; Seifollah Ahmadi; Johannes Brockhaus; Marina Sergejeva; Andreas Hess; Kay Brune; Jean-Marc Fritschy; Uwe Rudolph; Hanns Möhler; Hanns Ulrich Zeilhofer
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Nature 2008;451(7176):330-4.
2008: Cornelia Heindl; Andreas Hess; Kay Brune
Refinement and reduction in animal experimentation: options for new imaging techniques.
ALTEX 2008;25(2):121-5.
2007: Cornelia Heindl; Kay Brune; Bertold Renner
Kinetics and functional characterization of the glycine receptor alpha2 and alpha3 subunit.
Neuroscience letters 2007;429(1):59-63.
2007: Kay Brune
Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability.
Current medical research and opinion 2007;23(12):2985-95.
2007: Burkhard Hinz; Olga Cheremina; Jouri Bachmakov; Bertold Renner; Oliver Zolk; Martin F Fromm; Kay Brune
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2343-51.
2007: Bertold Renner; Geoff Clarke; Tim Grattan; Angelika Beisel; Christian Mueller; Ulrike Werner; Gerd Kobal; Kay Brune
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.
Journal of clinical pharmacology 2007;47(6):715-26.
2007: Ruzica Puljic; Ewald Benediktus; Christine Plater-Zyberk; Patrick A Baeuerle; Stefan Szelenyi; Kay Brune; Andreas Pahl
Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF.
European journal of pharmacology 2007;557(2-3):230-5.
2007: Sonja Eberl; Bertold Renner; Antje Neubert; Mareike Reisig; Iouri Bachmakov; Jörg König; Frank Dörje; Thomas E Mürdter; Andreas Ackermann; Harald Dormann; Karl G Gassmann; Eckhart Hahn; Stefanie Zierhut; Kay Brune; Martin F Fromm
Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.
Clinical pharmacokinetics 2007;46(12):1039-49.
2007: Andreas Hess; Marina Sergejeva; Lubos Budinsky; Hanns Ulrich Zeilhofer; Kay Brune
Imaging of hyperalgesia in rats by functional MRI.
European journal of pain (London, England) 2007;11(1):109-19.
2006: Andreas Pahl; Artur Bauhofer; Ursula Petzold; Peter J Cnota; Joachim Maus; Kay Brune; Stefan Szelenyi
Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugs.
Biochemical pharmacology 2006;72(12):1690-6.
2006: Antje Neubert; Harald Dormann; Jutta Weiss; Manfred Criegee-Rieck; Andreas Ackermann; Micha Levy; Kay Brune; Wolfgang Rascher
Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients?
European journal of clinical pharmacology 2006;62(11):959-65.
2006: Olga Cheremina; Kay Brune; Burkhard Hinz
A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasma.
Biomedical chromatography : BMC 2006;20(10):1033-7.
2006: Ulrike Werner; C Lamprecht; Dierk Werner; Simon Schaefer; Henrike Wuttke; Burkhard Hinz; Martin F Fromm; Kay Brune
Valdecoxib does not interfere with the CYP2D6 substrate metoprolol.
International journal of clinical pharmacology and therapeutics 2006;44(9):397-400.
2006: Dirk Baumjohann; Andreas Hess; Lubos Budinsky; Kay Brune; Gerold Schuler; Manfred B Lutz
In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice.
European journal of immunology 2006;36(9):2544-55.
2006: Wolfram-Hubertus Zimmermann; Ivan Melnychenko; Gerald H Wasmeier; Michael Didié; Hiroshi Naito; Uwe Nixdorff; Andreas Hess; Lubos Budinsky; Kay Brune; Bjela Michaelis; Stefan Dhein; Alexander Peter Schwoerer; Heimo Ehmke; Thomas Eschenhagen
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.
Nature medicine 2006;12(4):452-8.
2006: Andreas Schmidt; Kay Brune; Burkhard Hinz
Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2006;20(4):336-42.
2006: Susanne Rösch; Robert Ramer; Kay Brune; Burkhard Hinz
R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1219-28.
2006: Andreas Pahl; Stefan Szelenyi; Kay Brune
Hypoxia induced chemokine expression in nasal epithelial cells: development of an in vitro model for chronic rhinosinusitis.
ALTEX 2006;23(2):59-63.
2006: Burkhard Hinz; Harald Dormann; Kay Brune
More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib.
Arthritis and rheumatism 2006;54(1):282-91.
2006: Karin Eichele; Ulrike Weinzierl; Robert Ramer; Kay Brune; Burkhard Hinz
R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells.
Pharmaceutical research 2006;23(1):90-4.
2005: Susanne Rösch; Robert Ramer; Kay Brune; Burkhard Hinz
Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.
Biochemical and biophysical research communications 2005;338(2):1171-8.
2005: Olga Cheremina; Iouri Bachmakov; Antje Neubert; Kay Brune; Martin F Fromm; Burkhard Hinz
Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2005;19(10):777-82.
2005: Burkhard Hinz; Susanne Rösch; Robert Ramer; Ernst R Tamm; Kay Brune
Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(13):1929-31.
2005: Christoph Lamprecht; Ulrike Werner; Dierk Werner; Simon Schaefer; Bertold Renner; Martin F Fromm; Kay Brune
Effect of selective cyclooxygenase-2 inhibitors on heart rate in healthy young men.
The American journal of cardiology 2005;95(12):1531-2.
2005: Heiko Reinold; Seifollah Ahmadi; Ulrike B Depner; Beate Layh; Cornelia Heindl; May Hamza; Andreas Pahl; Kay Brune; Shuh Narumiya; Ulrike Müller; Hanns Ulrich Zeilhofer
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
The Journal of clinical investigation 2005;115(3):673-9.
2005: Ulrike Werner; Dierk Werner; Burkhard Hinz; Christoph Lambrecht; Kay Brune
A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma.
Biomedical chromatography : BMC 2005;19(2):113-8.
2005: Ligia Chialda; Meixia Zhang; Kay Brune; Andreas Pahl
Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia.
Respiratory research 2005;6():36.
2005: Tobias Egger; Harald Dormann; Gabi Ahne; Andreas Pahl; Ulrich Runge; Tanya Azaz-Livshits; Antje Neubert; Manfred Criegee-Rieck; Karl G Gassmann; Kay Brune
Cytochrome p450 polymorphisms in geriatric patients: impact on adverse drug reactions--a pilot study.
Drugs & aging 2005;22(3):265-72.
2005: Kay Brune
[Treatment of musculoskeletal pain].
Medizinische Monatsschrift für Pharmazeuten 2005;28(1):19-23.
2005: Burkhard Hinz; Julia Chevts; Bertold Renner; Henrike Wuttke; Thomas Rau; Andreas Schmidt; Istvan Szelenyi; Kay Brune; Ulrike Werner
Bioavailability of diclofenac potassium at low doses.
British journal of clinical pharmacology 2005;59(1):80-4.
2004: Burkhard Hinz; Robert Ramer; Karin Eichele; Ulrike Weinzierl; Kay Brune
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells.
Molecular pharmacology 2004;66(6):1643-51.
2004: Dierk Werner; Henrike Wuttke; Martin F Fromm; Simon Schaefer; Thomas Eschenhagen; Kay Brune; Werner G Daniel; Ulrike Werner
Effect of amiodarone on the plasma levels of metoprolol.
The American journal of cardiology 2004;94(10):1319-21.
2004: Burkhard Hinz; Robert Ramer; Karin Eichele; Ulrike Weinzierl; Kay Brune
R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts.
Biochemical and biophysical research communications 2004;324(2):621-6.
2004: Burkhard Hinz; Kay Brune
Pain and osteoarthritis: new drugs and mechanisms.
Current opinion in rheumatology 2004;16(5):628-33.
2004: Kay Brune; Burkhard Hinz
The discovery and development of antiinflammatory drugs.
Arthritis and rheumatism 2004;50(8):2391-9.
2004: Harald Dormann; Antje Neubert; Manfred Criegee-Rieck; Tobias Egger; Martin Radespiel-Tröger; Tanya Azaz-Livshits; Micha Levy; Kay Brune; Eckhart Hahn
Readmissions and adverse drug reactions in internal medicine: the economic impact.
Journal of internal medicine 2004;255(6):653-63.
2004: Kay Brune
[New evaluation by the EU approval committee. Benefits of cox-2 inhibitors outweigh possible risks (interview by Dr. Thomas Meissner)].
MMW Fortschritte der Medizin 2004;146(9):47.
2004: Harald Dormann; Manfred Criegee-Rieck; Antje Neubert; Tobias Egger; Micha Levy; Eckhart Hahn; Kay Brune
Implementation of a computer-assisted monitoring system for the detection of adverse drug reactions in gastroenterology.
Alimentary pharmacology & therapeutics 2004;19(3):303-9.
2004: Kay Brune
Safety of anti-inflammatory treatment--new ways of thinking.
Rheumatology (Oxford, England) 2004;43 Suppl 1():i16-20.
2004: Antje Neubert; Harald Dormann; Jutta Weiss; Tobias Egger; Manfred Criegee-Rieck; Wolfgang Rascher; Kay Brune; Burkhard Hinz
The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients.
Drug safety : an international journal of medical toxicology and drug experience 2004;27(13):1059-67.
2004: Kay Brune
Replacement and refinement of animal experimentation in drug research has been and will be a permanent and necessary process.
ALTEX 2004;21(1):38-41.
2003: Robert Ramer; Ulrike Weinzierl; Bianca Schwind; Kay Brune; Burkhard Hinz
Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells.
Molecular pharmacology 2003;64(5):1189-98.
2003: Burkhard Hinz; Thomas Rau; Daniel Auge; Ulrike Werner; Robert Ramer; Stephan Rietbrock; Kay Brune
Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac.
Clinical pharmacology and therapeutics 2003;74(3):222-35.
2003: Ulrike Werner; Dierk Werner; Thomas Rau; Martin F Fromm; Burkhard Hinz; Kay Brune
Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans.
Clinical pharmacology and therapeutics 2003;74(2):130-7.
2003: Andreas Schmidt; Bianca Schwind; Martin Gillich; Kay Brune; Burkhard Hinz
Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2003;17(4):276-81.
2003: Burkhard Hinz; Daniel Auge; Thomas Rau; Stephan Rietbrock; Kay Brune; Ulrike Werner
Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2003;17(4):268-75.
2003: Ulrike B Depner; Rainer K Reinscheid; Hiroshi Takeshima; Kay Brune; Hanns Ulrich Zeilhofer
Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor.
The European journal of neuroscience 2003;17(11):2381-7.
2003: Burkhard Hinz; Kay Brune; Andreas Pahl
15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.
Biochemical and biophysical research communications 2003;302(2):415-20.
2003: Tobias Egger; Harald Dormann; Gabi Ahne; Ulrich Runge; Antje Neubert; Manfred Criegee-Rieck; Karl G Gassmann; Kay Brune
Identification of adverse drug reactions in geriatric inpatients using a computerised drug database.
Drugs & aging 2003;20(10):769-76.
2003: Burkhard Hinz; Robert Ramer; Kay Brune
Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide.
Advances in experimental medicine and biology 2003;525():145-52.
2003: Kay Brune
[Self experimentation and in vitro research will not suffice: a plea for more refinement].
ALTEX 2003;20(1):48-50.
2003: Harald Dormann; Manfred Criegee-Rieck; Antje Neubert; Tobias Egger; Arnim Geise; Sabine Krebs; Thomas Schneider; Micha Levy; Eckhart Hahn; Kay Brune
Lack of awareness of community-acquired adverse drug reactions upon hospital admission : dimensions and consequences of a dilemma.
Drug safety : an international journal of medical toxicology and drug experience 2003;26(5):353-62.
2002: Andreas Pahl; Kay Brune
Stabilization of gene expression profiles in blood after phlebotomy.
Clinical chemistry 2002;48(12):2251-3.
2002: Hans Gühring; May Hamza; Marina Sergejeva; Mehmet Ates; Carolin E Kotalla; Catherine Ledent; Kay Brune
A role for endocannabinoids in indomethacin-induced spinal antinociception.
European journal of pharmacology 2002;454(2-3):153-63.
2002: Christopher Schmitt; Andreas Humeny; Cord-Michael Becker; Kay Brune; Andreas Pahl
Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles.
Clinical chemistry 2002;48(10):1661-7.
2002: Jutta Weiss; Sabine Krebs; Claudia Hoffmann; Ulrike Werner; Antje Neubert; Kay Brune; Wolfgang Rascher
Survey of adverse drug reactions on a pediatric ward: a strategy for early and detailed detection.
Pediatrics 2002;110(2 Pt 1):254-7.
2002: Johannes Schuster; Mehmet Ates; Kay Brune; Hans Gühring
The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.
Neuroscience letters 2002;326(3):196-200.
2002: Andreas Pahl; Meixia Zhang; Katalin Török; Hildegard Kuss; Ute Friedrich; Zoltán Magyar; Jozsef Szekely; Katalin Horvath; Kay Brune; Istvan Szelenyi
Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787.
The Journal of pharmacology and experimental therapeutics 2002;301(2):738-46.
2002: Istvan Szelenyi; Kay Brune
Herbal remedies for asthma treatment: between myth and reality.
Drugs of today (Barcelona, Spain : 1998) 2002;38(4):265-303.
2002: Andreas Pahl; Meixia Zhang; Hildegard Kuss; Istvan Szelenyi; Kay Brune
Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy.
British journal of pharmacology 2002;135(8):1915-26.
2002: Ulrike Werner; Dierk Werner; Andreas Pahl; Ralf G Mundkowski; Martin Gillich; Kay Brune
Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry.
Biomedical chromatography : BMC 2002;16(1):56-60.
2002: Burkhard Hinz; Kay Brune
Cyclooxygenase-2--10 years later.
The Journal of pharmacology and experimental therapeutics 2002;300(2):367-75.
2002: Kay Brune
Animal experimentation in sciences: sadistic nonsense or indispensable necessity?
ALTEX 2002;19(3):130-6.
2002: Kay Brune; Tobias Egger
[World-wide sales power of a drug group! The evolution of antipyretic analgesics].
Pharmazie in unserer Zeit 2002;31(2):133-9.
2001: Hans Gühring; J Schuster; May Hamza; Mehmet Ates; Carolin E Kotalla; Kay Brune
HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test.
European journal of pharmacology 2001;429(1-3):127-34.
2001: Jörn Lötsch; Uta Muth-Selbach; Irmgard Tegeder; Kay Brune; Gerd Geisslinger
Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate.
British journal of clinical pharmacology 2001;52(4):387-98.
2001: Christian Maihöfner; Ursula Schlötzer-Schrehardt; Hans Gühring; Hanns Ulrich Zeilhofer; Gottfried Naumann; Andreas Pahl; Christian Y Mardin; Ernst R Tamm; Kay Brune
Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes.
Investigative ophthalmology & visual science 2001;42(11):2616-24.
2001: Robert Ramer; Kay Brune; Andreas Pahl; Burkhard Hinz
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Biochemical and biophysical research communications 2001;286(5):1144-52.
2001: Ulrike Werner; Dierk Werner; Ralf G Mundkowski; Martin Gillich; Kay Brune
Selective and rapid liquid chromatography-mass spectrometry method for the quantification of rofecoxib in pharmacokinetic studies with humans.
Journal of chromatography. B, Biomedical sciences and applications 2001;760(1):83-90.
2001: J Damm; Thomas Rau; Christian Maihöfner; Andreas Pahl; Kay Brune
Constitutive expression and localization of COX-1 and COX-2 in rabbit iris and ciliary body.
Experimental eye research 2001;72(6):611-21.
2001: R Bruggera; C Reichel; B Garcia Alia; Kay Brune; T Yamamoto; Irmgard Tegeder; Gerd Geisslinger; G Geissinger
Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics.
Biochemical pharmacology 2001;61(6):651-6.
2001: Irmgard Tegeder; Ellen Niederberger; E Israr; Hans Gühring; Kay Brune; C Euchenhofer; Sabine Grösch; Gerd Geisslinger
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):595-7.
2001: Burkhard Hinz; Kay Brune; Thomas Rau; Andreas Pahl
Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages.
Pharmaceutical research 2001;18(2):151-6.
2001: Hans Gühring; Irmgard Tegeder; Jörn Lötsch; Andreas Pahl; Ulrike Werner; Peter W Reeh; K Rehse; Kay Brune; Gerd Geisslinger
Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(2):83-8.
2001: Harald Dormann; Sabine Krebs; Uta Muth-Selbach; Manfred Criegee-Rieck; Martin Radespiel-Tröger; Micha Levy; Eckhart Hahn; Kay Brune; H Thomas Schneider
Adverse drug reactions in patients with gastroenterological diseases: does age increase the risk?
Alimentary pharmacology & therapeutics 2001;15(2):171-80.
2001: M Sommerauer; M Ates; Hans Gühring; Kay Brune; Rainer Amann; Bernhard A Peskar
Ketoprofen-induced cyclooxygenase inhibition in renal medulla and platelets of rats treated with caffeine.
Pharmacology 2001;63(4):234-9.
2001: Sabine Krebs; Harald Dormann; Uta Muth-Selbach; Eckhart Hahn; Kay Brune; H Thomas Schneider
Risperidone-induced cholestatic hepatitis.
European journal of gastroenterology & hepatology 2001;13(1):67-9.
2001: Irmgard Tegeder; Ellen Niederberger; E Israr; Hans Gühring; Kay Brune; C Euchenhofer; Sabine Grösch; Gerd Geisslinger
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):2-4.
2000: Burkhard Hinz; Kay Brune; Andreas Pahl
Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugs.
Biochemical and biophysical research communications 2000;278(3):790-6.
2000: Ulrike Werner; Kay Brune; Beate Layh; H Guehring
Determination of L-iminoethyl-L-lysine in serum by liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;749(1):35-40.
2000: K Grosser; R Oelkers; Thomas Hummel; Gerd Geisslinger; Kay Brune; Gerd Kobal; Jörn Lötsch
Olfactory and trigeminal event-related potentials in migraine.
Cephalalgia : an international journal of headache 2000;20(7):621-31.
2000: Hans Gühring; M Görig; Mehmet Ates; O Coste; Hanns Ulrich Zeilhofer; Andreas Pahl; K Rehse; Kay Brune
Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6714-20.
2000: Sabine Krebs; Harald Dormann; Eckhart Hahn; H Thomas Schneider; Kay Brune
[Adverse drug effects. Prevention, detection and early intervention by a computer-assisted early warning system].
Deutsche medizinische Wochenschrift (1946) 2000;125(33):984-7.
2000: Burkhard Hinz; V Kraus; Andreas Pahl; Kay Brune
Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.
Biochemical and biophysical research communications 2000;274(1):197-202.
2000: Andrea Hartner; Andreas Pahl; Kay Brune; Margarete Goppelt-Struebe
Upregulation of cyclooxygenase-1 and the PGE2 receptor EP2 in rat and human mesangioproliferative glomerulonephritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2000;49(7):345-54.
2000: Burkhard Hinz; Kay Brune; Andreas Pahl
Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Biochemical and biophysical research communications 2000;272(3):744-8.
2000: H Bang; Anja Pecht; G Raddatz; T Scior; Werner Solbach; Kay Brune; Andreas Pahl
Prolyl isomerases in a minimal cell. Catalysis of protein folding by trigger factor from Mycoplasma genitalium.
European journal of biochemistry / FEBS 2000;267(11):3270-80.
2000: Burkhard Hinz; Kay Brune; Andreas Pahl
Nitric oxide inhibits inducible nitric oxide synthase mRNA expression in RAW 264.7 macrophages.
Biochemical and biophysical research communications 2000;271(2):353-7.
2000: Gerd Geisslinger; Uta Muth-Selbach; Ovidiu Coste; Gregor Vetter; A Schrödter; H G Schaible; Kay Brune; Irmgard Tegeder
Inhibition of noxious stimulus-induced spinal prostaglandin E2 release by flurbiprofen enantiomers: a microdialysis study.
Journal of neurochemistry 2000;74(5):2094-100.
2000: B Hinz; Kay Brune
[Gastric protective pain therapy. What is the advantage of new COX-2 inhibitors?].
MMW Fortschritte der Medizin 2000;142(11):39-40.
2000: Harald Dormann; Uta Muth-Selbach; Sabine Krebs; Manfred Criegee-Rieck; Irmgard Tegeder; H Thomas Schneider; Eckhart Hahn; Micha Levy; Kay Brune; Gerd Geisslinger
Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting.
Drug safety : an international journal of medical toxicology and drug experience 2000;22(2):161-8.
2000: Christian Maihöfner; Irmgard Tegeder; C Euchenhofer; D deWitt; Kay Brune; R Bang; Winfried Neuhuber; Gerd Geisslinger
Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord.
Neuroscience 2000;101(4):1093-108.
2000: J Lötsch; Birgit Kettenmann; Bertold Renner; David R Drover; Kay Brune; G Geisslinger; Gerd Kobal
Population pharmacokinetics of fast release oral diclofenac in healthy volunteers: relation to pharmacodynamics in an experimental pain model.
Pharmaceutical research 2000;17(1):77-84.
1999: Uta Muth-Selbach; I Tegeder; Kay Brune; Gerd Geisslinger
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.
Anesthesiology 1999;91(1):231-9.
1999: R Oelkers; K Grosser; Eberhard Lang; Gerd Geisslinger; Gerd Kobal; Kay Brune; Jörn Lötsch
Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency.
Brain : a journal of neurology 1999;122 ( Pt 6)():1147-55.
1999: Irmgard Tegeder; Jörn Lötsch; Sabine Krebs; Uta Muth-Selbach; Kay Brune; Gerd Geisslinger
Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state.
Clinical pharmacology and therapeutics 1999;65(5):533-44.
1999: Irmgard Tegeder; Micha Levy; Uta Muth-Selbach; R Oelkers; F Neumann; Harald Dormann; Tanya Azaz-Livshits; Manfred Criegee-Rieck; H Thomas Schneider; Eckhart Hahn; Kay Brune; Gerd Geisslinger
Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals.
British journal of clinical pharmacology 1999;47(5):557-64.
1999: Irmgard Tegeder; Uta Muth-Selbach; Jörn Lötsch; G Rüsing; R Oelkers; Kay Brune; S Meller; Gary R Kelm; Fritz Sörgel; Gerd Geisslinger
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration.
Clinical pharmacology and therapeutics 1999;65(4):357-68.
1999: B Hinz; Kay Brune
[Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances].
Wiener klinische Wochenschrift 1999;111(3):103-12.
1999: Burkhard Hinz; Kay Brune
[COX-1 and COX-2: functions and pharmacological effects].
Pharmazie in unserer Zeit 1999;28(1):21-9.
1999: Irmgard Tegeder; F Neumann; Frank Bremer; Kay Brune; Jörn Lötsch; Gerd Geisslinger
Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration.
Clinical pharmacology and therapeutics 1999;65(1):50-7.
1998: Kay Brune; B Hinz
[2-Arylpropionic acids. Role in pain therapy].
Schmerz (Berlin, Germany) 1998;12(6):383-8.
1998: F Beiche; Kay Brune; Gerd Geisslinger; Margarete Goppelt-Struebe
Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1998;47(12):482-7.
1998: C Rascher; Andreas Pahl; Anja Pecht; Kay Brune; Werner Solbach; H Bang
Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin.
The Biochemical journal 1998;334 ( Pt 3)():659-67.
1998: C Euchenhofer; C Maihófner; Kay Brune; Irmgard Tegeder; Gerd Geisslinger
Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.
Neuroscience letters 1998;248(1):25-8.
1998: S Scheuerer; K M Williams; R Brugger; A J McLachlan; Kay Brune; R O Day; Gerd Geisslinger
Effect of clofibrate on the chiral disposition of ibuprofen in rats.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1132-8.
1998: N Scheuren; H Bang; Tino Münster; Kay Brune; Andreas Pahl
Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen.
British journal of pharmacology 1998;123(4):645-52.
1997: Irmgard Tegeder; Frank Bremer; R Oelkers; Hans P Schobel; Jürgen Schüttler; Kay Brune; Gerd Geisslinger
Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration.
Antimicrobial agents and chemotherapy 1997;41(12):2640-5.
1997: Jörn Lötsch; Gerd Kobal; A Stockmann; Kay Brune; Gerd Geisslinger
Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers.
Anesthesiology 1997;87(6):1348-58.
1997: W Neupert; R Brugger; C Euchenhofer; Kay Brune; Gerd Geisslinger
Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases.
British journal of pharmacology 1997;122(3):487-92.
1997: I Tegeder; A Schumacher; S John; H Geiger; G Geisslinger; H Bang; Kay Brune
Elevated serum cyclophilin levels in patients with severe sepsis.
Journal of clinical immunology 1997;17(5):380-6.
1997: Andreas Pahl; Kay Brune; H Bang
Fit for life? Evolution of chaperones and folding catalysts parallels the development of complex organisms.
Cell stress & chaperones 1997;2(2):78-86.
1997: K Erb; JT Liebel; Irmgard Tegeder; Hanns Ulrich Zeilhofer; Kay Brune; Gerd Geisslinger
Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test.
Neuroreport 1997;8(8):1967-70.
1997: A Hoerauf; C Rascher; R Bang; Andreas Pahl; Werner Solbach; Kay Brune; Martin Röllinghoff; H Bang
Host-cell cyclophilin is important for the intracellular replication of Leishmania major.
Molecular microbiology 1997;24(2):421-9.
1997: Gerd Geisslinger; Kay Brune; Gerd Kobal; Jörn Lötsch
Intravenous morphine-6-glucuronide (M6G) is devoid of analgesic activity in man.
Pain 1997;70(2-3):289-90.
1997: C Reichel; R Brugger; H Bang; Gerd Geisslinger; Kay Brune
Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: a key enzyme in the inversion metabolism of ibuprofen.
Molecular pharmacology 1997;51(4):576-82.
1997: R Oelkers; W Neupert; K M Williams; Kay Brune; Gerd Geisslinger
Disposition and effects of flurbiprofen enantiomers in human serum and blister fluid.
British journal of clinical pharmacology 1997;43(2):145-53.
1997: N Scheuren; H Bang; Tino Münster; Kay Brune; Andreas Pahl
Weak inhibitors of cyclooxygenases may exert their antinociceptive effect by modulation of transcription factors.
Advances in experimental medicine and biology 1997;433():51-4.
1997: N Scheuren; W Neupert; M Ionac; Winfried Neuhuber; Kay Brune; Gerd Geisslinger
Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat.
Life sciences 1997;60(21):PL 295-300.
1996: W Neupert; R Oelkers; Kay Brune; Gerd Geisslinger
A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate.
Prostaglandins 1996;52(5):385-401.
1996: R Brugger; B García Alía; C Reichel; R Waibel; S Menzel; Kay Brune; Gerd Geisslinger
Isolation and characterization of rat liver microsomal R-ibuprofenoyl-CoA synthetase.
Biochemical pharmacology 1996;52(7):1007-13.
1996: Gerd Geisslinger; Bernhard A Peskar; D Pallapies; R Sittl; Micha Levy; Kay Brune
The effects on platelet aggregation and prostanoid biosynthesis of two parenteral analgesics: ketorolac tromethamine and dipyrone.
Thrombosis and haemostasis 1996;76(4):592-7.
1996: R Oelkers; M Ionac; K Erb; Kay Brune; Gerd Geisslinger
Transfer of different nonsteroidal antiinflammatory drugs via the lymphatic system in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(10):1107-10.
1996: Jörn Lötsch; A Stockmann; Gerd Kobal; Kay Brune; R Waibel; N Schmidt; Gerd Geisslinger
Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers.
Clinical pharmacology and therapeutics 1996;60(3):316-25.
1996: F Beiche; S Scheuerer; Kay Brune; Gerd Geisslinger; Margarete Goppelt-Struebe
Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation.
FEBS letters 1996;390(2):165-9.
1996: M Ionac; R Oelkers; Kay Brune; Gerd Geisslinger; D Bordos
Lymph distribution of different non-steroidal anti-inflammatory drugs assessed by microsurgical cannulation of the thoracic duct in rat.
Romanian journal of internal medicine = Revue roumaine de médecine interne 1996;34(3-4):239-51.
1996: M Ionac; Michael John Parnham; M Plauchithiu; Kay Brune
Oxaceprol, an atypical inhibitor of inflammation and joint damage.
Pharmacological research : the official journal of the Italian Pharmacological Society 1996;33(6):367-73.
1996: M Ionac; D Bordos; Gerd Geisslinger; Kay Brune
[An experimental model of the microsurgical cannulation of the thoracic duct in the rat].
Chirurgia (Bucharest, Romania : 1990) 1996;45(3):147-9.
1996: Gerd Geisslinger; S Menzel; Kay Brune
Stereospecific determination of tiaprofenic acid in plasma: problems with drug degradation.
Journal of chromatography. B, Biomedical applications 1996;675(1):77-81.
1996: M Ionac; Gerd Geisslinger; Kay Brune; D Bordos
[A microsurgical approach to drainage of the thoracic duct in the rat].
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i 1996;100(1-2):112-7.
1995: Jörn Lötsch; Parvaneh Mohammadian; Thomas Hummel; S Florin; Kay Brune; Gerd Geisslinger; Gerd Kobal
Effects of azapropazone on pain-related brain activity in human subjects.
British journal of clinical pharmacology 1995;40(6):545-52.
1995: C Reichel; H Bang; Kay Brune; Gerd Geisslinger; S Menzel
2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization.
Biochemical pharmacology 1995;50(11):1803-6.
1995: Jörn Lötsch; Gerd Geisslinger; Parvaneh Mohammadian; Kay Brune; Gerd Kobal
Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects.
British journal of clinical pharmacology 1995;40(4):339-46.
1995: H Ernst; S Grunert; H Thomas Schneider; W S Beck; Kay Brune; Eckhart Hahn
Distribution of extracellular matrix proteins in indomethacin-induced lesions in the rat stomach.
Scandinavian journal of gastroenterology 1995;30(9):847-53.
1995: U Krummrei; Renate Bang; R Schmidtchen; Kay Brune; H Bang
Cyclophilin-A is a zinc-dependent DNA binding protein in macrophages.
FEBS letters 1995;371(1):47-51.
1995: S Kilo; Clemens Forster; Gerd Geisslinger; Kay Brune; Hermann O Handwerker
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
Pain 1995;62(2):187-93.
1995: Kay Brune
[Non-steroidal anti-inflammatory drugs (NSAIDs): Antirheumatic, anti-pyretic or analgesic drugs?].
Schmerz (Berlin, Germany) 1995;9(4):166-72.
1995: Gerd Geisslinger; S Menzel; K Wissel; Kay Brune
Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate.
British journal of clinical pharmacology 1995;40(1):73-5.
1995: Werner Hering; R Schlecht; Gerd Geisslinger; G Biburger; M Dinkel; Kay Brune; E Rügheimer
EEG analysis and pharmacodynamic modelling after intravenous bolus injection of eltanolone (pregnanolone).
European journal of anaesthesiology 1995;12(4):407-15.
1994: D Pallapies; Bernhard A Peskar; Kay Brune; H U Zeilhofer
Modulation of nitric oxide effects by flurbiprofen enantiomers and nefopam and its relation to antinociception.
European journal of pharmacology 1994;271(2-3):335-40.
1994: Werner Hering; Gerd Geisslinger; H D Kamp; M Dinkel; Klaus Tschaikowsky; E Rügheimer; Kay Brune
Changes in the EEG power spectrum after midazolam anaesthesia combined with racemic or S- (+) ketamine.
Acta anaesthesiologica Scandinavica 1994;38(7):719-23.
1994: S Menzel; R Waibel; Kay Brune; Gerd Geisslinger
Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion?
Biochemical pharmacology 1994;48(5):1056-8.
1994: N Schmidt; Kay Brune; Gerd Geisslinger
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum.
European journal of pharmacology 1994;255(1-3):245-7.
1994: Gerd Geisslinger; Jörn Lötsch; S Menzel; Gerd Kobal; Kay Brune
Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers.
British journal of clinical pharmacology 1994;37(4):392-4.
1994: D Pallapies; Bernhard A Peskar; Kay Brune; Gerd Geisslinger
Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses.
British journal of clinical pharmacology 1994;37(4):335-9.
1994: S Menzel; C Sauernheimer; Kay Brune; Gerd Geisslinger
Is the inversion from R- to S-ketoprofen concentration dependent? Investigations in rats in vivo and in vitro.
Biochemical pharmacology 1994;47(7):1267-70.
1994: Gerd Geisslinger; S H Ferreira; S Menzel; D Schlott; Kay Brune
Antinociceptive actions of R(-)-flurbiprofen--a non-cyclooxygenase inhibiting 2-arylpropionic acid--in rats.
Life sciences 1994;54(10):PL173-7.
1994: Ulrich Feige; A Schulmeister; Juergen Mollenhauer; Kay Brune; H Bang
A constitutive 65 kDa chondrocyte protein as a target antigen in adjuvant arthritis in Lewis rats.
Autoimmunity 1994;17(3):233-9.
1994: N Schmidt; Kay Brune; K M Williams; Gerd Geisslinger
Stereoselective pharmacokinetics of methadone in beagle dogs.
Chirality 1994;6(6):492-5.
1994: Kay Brune
Spinal cord effects of antipyretic analgesics.
Drugs 1994;47 Suppl 5():21-7; discussion 46-7.
1993: H Bang; Kay Brune; C Nager; Ulrich Feige
Interleukin-8 is a cyclosporin A binding protein.
Experientia 1993;49(6-7):533-8.
1993: Gerd Geisslinger; K P Stock; D Loew; G L Bach; Kay Brune
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.
British journal of clinical pharmacology 1993;35(6):603-7.
1993: Gerd Geisslinger; Werner Hering; P Thomann; R Knoll; H D Kamp; Kay Brune
Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.
British journal of anaesthesia 1993;70(6):666-71.
1993: J A van Hilten; Kay Brune; D Bickel; Juergen Mollenhauer
Characterization of macrophage proteins bearing the functional leukotriene D4-binding site of an anti-cysteinylleukotriene monoclonal antibody.
European journal of biochemistry / FEBS 1993;214(1):83-90.
1993: N Schmidt; R Sittl; Kay Brune; Gerd Geisslinger
Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring.
Pharmaceutical research 1993;10(3):441-4.
1993: Johannes F E Mann; M Goerig; Kay Brune; Friedrich C Luft
Ibuprofen as an over-the-counter drug: is there a risk for renal injury?
Clinical nephrology 1993;39(1):1-6.
1993: S Menzel; W S Beck; Kay Brune; Gerd Geisslinger
Stereoselectivity of biliary excretion of 2-arylpropionates in rats.
Chirality 1993;5(6):422-7.
1993: S Menzel-Soglowek; Gerd Geisslinger; Kay Brune
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines.
Agents and actions. Supplements 1993;44():23-9.
1993: Kay Brune; B Nuernberg; H Thomas Schneider
Biliary elimination of aspirin after oral and intravenous administration in patients.
Agents and actions. Supplements 1993;44():51-7.
1993: Gerd Geisslinger; S Menzel-Soglowek; W S Beck; Kay Brune
R-flurbiprofen: isomeric ballast or active entity of the racemic compound?
Agents and actions. Supplements 1993;44():31-6.
1992: N Schmidt; Kay Brune; Gerd Geisslinger
Stereoselective determination of the enantiomers of methadone in plasma using high-performance liquid chromatography.
Journal of chromatography 1992;583(2):195-200.
1992: Kay Brune; Gerd Geisslinger; S Menzel-Soglowek
Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology.
Journal of clinical pharmacology 1992;32(10):944-52.
1992: S Menzel-Soglowek; Gerd Geisslinger; W S Beck; Kay Brune
Variability of inversion of (R)-flurbiprofen in different species.
Journal of pharmaceutical sciences 1992;81(9):888-91.
1992: S Menzel-Soglowek; Gerd Geisslinger; Juergen Mollenhauer; Kay Brune
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.
Biochemical pharmacology 1992;43(7):1487-92.
1992: Hanns Ulrich Zeilhofer; Dieter Swandulla; Gerd Geisslinger; Kay Brune
Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons.
European journal of pharmacology 1992;213(1):155-8.
1992: D Mettal; Kay Brune; Juergen Mollenhauer
Cytotoxic effects of rheumatoid arthritis sera on chondrocytes.
Biochimica et biophysica acta 1992;1138(2):85-92.
1992: Gerd Geisslinger; S Menzel-Soglowek; O Schuster; Kay Brune
Stereoselective high-performance liquid chromatographic determination of flurbiprofen in human plasma.
Journal of chromatography 1992;573(1):163-7.
1992: Kay Brune; S Menzel-Soglowek; Hanns Ulrich Zeilhofer
Differential analgesic effects of aspirin-like drugs.
Drugs 1992;44 Suppl 5():52-8; discussion 58-9.
1991: Brigitta M Peskar; S Kluge; Bernhard A Peskar; S M Soglowek; Kay Brune
Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo.
Prostaglandins 1991;42(6):515-31.
1991: Gerd Geisslinger; S Menzel-Soglowek; H D Kamp; Kay Brune
Stereoselective high-performance liquid chromatographic determination of the enantiomers of ketamine and norketamine in plasma.
Journal of chromatography 1991;568(1):165-76.
1991: Kay Brune; W S Beck; Gerd Geisslinger; S Menzel-Soglowek; B M Peskar; B A Peskar
Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition.
Experientia 1991;47(3):257-61.
1991: M Reinke; U Hoppe; T Röder; HJ Bestmann; Juergen Mollenhauer; Kay Brune
A monoclonal antibody against the sulfidopeptide leukotrienes LTC4, LTD4 and LTE4.
Biochimica et biophysica acta 1991;1081(3):274-8.
1991: Kay Brune; W S Beck
Towards safer nonsteroidal anti-inflammatory drugs.
Agents and actions. Supplements 1991;32():13-25.
1991: B Nuernberg; G Koehler; Kay Brune
Pharmacokinetics of diflunisal in patients.
Clinical pharmacokinetics 1991;20(1):81-9.
1991: W S Beck; Gerd Geisslinger; H Engler; Kay Brune
Pharmacokinetics of ibuprofen enantiomers in dogs.
Chirality 1991;3(3):165-9.
1991: K P Stock; Gerd Geisslinger; D Loew; W S Beck; G L Bach; Kay Brune
S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritis.
Rheumatology international 1991;11(4-5):199-202.
1990: S Menzel-Soglowek; Gerd Geisslinger; Kay Brune
Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein column.
Journal of chromatography 1990;532(2):295-303.
1990: W S Beck; K Dietzel; Gerd Geisslinger; H Engler; H Vergin; Kay Brune
Effects of sodium salicylate on elimination kinetics of indomethacin and bile production in dogs.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):962-7.
1990: B Nuernberg; I Szelenyi; H Thomas Schneider; Kay Brune
Diflunisal disposition. Role of gastric absorption in the development of mucosal damage and anti-inflammatory potency in rodents.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):937-42.
1990: N Moeller; K Dietzel; B Nuernberg; Gerd Geisslinger; Kay Brune
High-performance liquid chromatographic determination of pentazocine in plasma.
Journal of chromatography 1990;530(1):200-5.
1990: I Jurna; Kay Brune
Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus.
Pain 1990;41(1):71-80.
1990: Gerd Kobal; Cornelia Hummel; B Nuernberg; Kay Brune
Effects of pentazocine and acetylsalicylic acid on pain-rating, pain-related evoked potentials and vigilance in relationship to pharmacokinetic parameters.
Agents and actions 1990;29(3-4):342-59.
1990: Gerd Geisslinger; O Schuster; K P Stock; D Loew; G L Bach; Kay Brune
Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis.
European journal of clinical pharmacology 1990;38(5):493-7.
1990: H Enzmann; Juergen Mollenhauer; Kay Brune
Humoral autoimmunity to cartilage in rheumatoid arthritis?
Agents and actions 1990;29(1-2):114-6.
1990: K Dietzel; W S Beck; H Thomas Schneider; Gerd Geisslinger; Kay Brune
The biliary elimination and enterohepatic circulation of ibuprofen in rats.
Pharmaceutical research 1990;7(1):87-90.
1990: H Thomas Schneider; B Nuernberg; K Dietzel; Kay Brune
Biliary elimination of non-steroidal anti-inflammatory drugs in patients.
British journal of clinical pharmacology 1990;29(1):127-31.
1990: Kay Brune
Is there a rational basis for the different spectra of adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs)?
Drugs 1990;40 Suppl 5():12-5.
1990: W S Beck; H Thomas Schneider; K Dietzel; B Nuernberg; Kay Brune
Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved.
Archives of toxicology 1990;64(3):210-7.
1989: Gerd Geisslinger; K Dietzel; H Bezler; B Nuernberg; Kay Brune
Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid.
International journal of clinical pharmacology, therapy, and toxicology 1989;27(7):324-8.
1989: Gerd Geisslinger; K Dietzel; D Loew; O Schuster; G Rau; G Lachmann; Kay Brune
High-performance liquid chromatographic determination of ibuprofen, its metabolites and enantiomers in biological fluids.
Journal of chromatography 1989;491(1):139-49.
1989: Gerd Geisslinger; K P Stock; G L Bach; D Loew; Kay Brune
Pharmacological differences between R(-)- and S(+)-ibuprofen.
Agents and actions 1989;27(3-4):455-7.
1989: M Reinke; M Piller; Kay Brune
Development of an enzyme-linked immunosorbent assay of thromboxane B2 using a monoclonal antibody.
Prostaglandins 1989;37(5):577-86.
1989: Kay Brune
Ten years research on inflammation revisited.
Agents and actions 1989;26(1-2):4-8.
1989: Hanns Ulrich Zeilhofer; Juergen Mollenhauer; Kay Brune
Selective growth inhibition of ductal pancreatic adenocarcinoma cells by the lysosomotropic agent chloroquine.
Cancer letters 1989;44(1):61-6.
1988: M Reinke; Kay Brune
A monoclonal anti-thromboxane B2 antibody.
FEBS letters 1988;232(1):46-50.
1988: Juergen Mollenhauer; Kay Brune
Detection of autoimmunoreactive antibodies against cartilage cell surface proteins in the blood of rheumatic patients.
Agents and actions 1988;23(1-2):48-9.
1988: Kay Brune
The pharmacological profile of non-opioid (OTC) analgesics: aspirin, paracetamol (acetaminophen), ibuprofen, and phenazones.
Agents and actions. Supplements 1988;25():9-19.
1987: Kay Brune
[Non-orthodox methods in pain therapy: Harmless and successful?].
Schmerz (Berlin, Germany) 1987;1(1):24-8.
1987: Kay Brune; K Dietzel; B Nürnberg; H Thomas Schneider
Recent insight into the mechanism of gastrointestinal tract ulceration.
European journal of rheumatology and inflammation 1987;9(2):8-14.
1987: Kay Brune; K Dietzel; B Nürnberg; H Thomas Schneider
Recent insight into the mechanism of gastrointestinal tract ulceration.
Scandinavian journal of rheumatology. Supplement 1987;65():135-40.