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Kay Brune

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Procedures

High Pressure Liquid Chromatography

Concepts & Ideas

Drug Dose-Response Relationship

Disorders

Pain

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Co-Publications
Name
74
Geisslinger, Gerd
36
Hinz, Burkhard
29
Pahl, Andreas
15
Tegeder, Irmgard
15
Dormann, Harald
14
Werner, Ulrike
13
Schneider, Thomas
13
Lötsch, Jörn
11
Hahn, Eckhart
11
Kobal, Gerd
11
Neubert, Antje
10
Ramer, Robert
10
Zeilhofer, Hanns Ulrich
10
Criegee-Rieck, Manfred
9
Bang, H

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Publications

TOP 3
Renner B; Brune K
Are myocardial infarctions and death in healthy individuals associated with the use of cyclooxygenase inhibitors?
Brune K; Renner B; Maas R
[Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous]
Brune Kay; Hinz Burkhard; Otterness Ivan
Aspirin and acetaminophen: should they be available over the counter?

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All Publications

2009: Renner B; Brune K
Are myocardial infarctions and death in healthy individuals associated with the use of cyclooxygenase inhibitors?
Clinical pharmacology and therapeutics 2009;86(6):599-600; author reply 602-4.
2009: Brune K; Renner B; Maas R
[Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous]
Deutsche medizinische Wochenschrift (1946) 2009;134(36):1771-3.
2009: Brune Kay; Hinz Burkhard; Otterness Ivan
Aspirin and acetaminophen: should they be available over the counter?
Current rheumatology reports 2009;11(1):36-40.
2008: Zopf Y; Rabe C; Neubert A; Gassmann K G; Rascher W; Hahn E G; Brune K; Dormann H
Women encounter ADRs more often than do men.
European journal of clinical pharmacology 2008;64(10):999-1004.
2008: Hinz Burkhard; Brune Kay
Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology.
Trends in pharmacological sciences 2008;29(8):391-7.
2008: Brune Kay; Katus Hugo A; Moecks Joachim; Spanuth Eberhard; Jaffe Allan S; Giannitsis Evangelos
N-terminal pro-B-type natriuretic peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trial.
Clinical chemistry 2008;54(7):1149-57.
2008: Hinz B; Cheremina O; Besz D; Zlotnick S; Brune K
Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers.
International journal of clinical pharmacology and therapeutics 2008;46(4):180-6.
2008: Hinz Burkhard; Cheremina Olga; Brune Kay
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(2):383-90.
2008: Knabl Julia; Witschi Robert; Hösl Katharina; Reinold Heiko; Zeilhofer Ulrike B; Ahmadi Seifollah; Brockhaus Johannes; Sergejeva Marina; Hess Andreas; Brune Kay; Fritschy Jean-Marc; Rudolph Uwe; Möhler Hanns; Zeilhofer Hanns Ulrich
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Nature 2008;451(7176):330-4.
2008: Heindl Cornelia; Hess Andreas; Brune Kay
Refinement and reduction in animal experimentation: options for new imaging techniques.
ALTEX : Alternativen zu Tierexperimenten 2008;25(2):121-5.
2007: Heindl Cornelia; Brune Kay; Renner Bertold
Kinetics and functional characterization of the glycine receptor alpha2 and alpha3 subunit.
Neuroscience letters 2007;429(1):59-63.
2007: Brune Kay
Persistence of NSAIDs at effect sites and rapid disappearance from side-effect compartments contributes to tolerability.
Current medical research and opinion 2007;23(12):2985-95.
2007: Hinz Burkhard; Cheremina Olga; Bachmakov Jouri; Renner Bertold; Zolk Oliver; Fromm Martin F; Brune Kay
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(10):2343-51.
2007: Renner Bertold; Clarke Geoff; Grattan Tim; Beisel Angelika; Mueller Christian; Werner Ulrike; Kobal Gerd; Brune Kay
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen.
Journal of clinical pharmacology 2007;47(6):715-26.
2007: Puljic Ruzica; Benediktus Ewald; Plater-Zyberk Christine; Baeuerle Patrick A; Szelenyi Stefan; Brune Kay; Pahl Andreas
Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF.
European journal of pharmacology 2007;557(2-3):230-5.
2007: Hess Andreas; Sergejeva Marina; Budinsky Lubos; Zeilhofer Hanns Ulrich; Brune Kay
Imaging of hyperalgesia in rats by functional MRI.
European journal of pain (London, England) 2007;11(1):109-19.
2007: Eberl Sonja; Renner Bertold; Neubert Antje; Reisig Mareike; Bachmakov Iouri; König Jörg; Dörje Frank; Mürdter Thomas E; Ackermann Andreas; Dormann Harald; Gassmann Karl G; Hahn Eckhart G; Zierhut Stefanie; Brune Kay; Fromm Martin F
Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.
Clinical pharmacokinetics 2007;46(12):1039-49.
2006: Pahl Andreas; Bauhofer Artur; Petzold Ursula; Cnota Peter J; Maus Joachim; Brune Kay; Szelenyi Stefan
Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugs.
Biochemical pharmacology 2006;72(12):1690-6.
2006: Neubert Antje; Dormann Harald; Weiss Jutta; Criegee-Rieck Manfred; Ackermann Andreas; Levy Micha; Brune Kay; Rascher Wolfgang
Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients?
European journal of clinical pharmacology 2006;62(11):959-65.
2006: Cheremina Olga; Brune Kay; Hinz Burkhard
A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasma.
Biomedical chromatography : BMC 2006;20(10):1033-7.
2006: Werner U; Lamprecht C; Werner D; Schaefer S; Wuttke H; Hinz B; Fromm M F; Brune K
Valdecoxib does not interfere with the CYP2D6 substrate metoprolol.
International journal of clinical pharmacology and therapeutics 2006;44(9):397-400.
2006: Baumjohann Dirk; Hess Andreas; Budinsky Lubos; Brune Kay; Schuler Gerold; Lutz Manfred B
In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice.
European journal of immunology 2006;36(9):2544-55.
2006: Zimmermann Wolfram-Hubertus; Melnychenko Ivan; Wasmeier Gerald; Didié Michael; Naito Hiroshi; Nixdorff Uwe; Hess Andreas; Budinsky Lubos; Brune Kay; Michaelis Bjela; Dhein Stefan; Schwoerer Alexander; Ehmke Heimo; Eschenhagen Thomas
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts.
Nature medicine 2006;12(4):452-8.
2006: Schmidt Andreas; Brune Kay; Hinz Burkhard
Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2006;20(4):336-42.
2006: Rösch Susanne; Ramer Robert; Brune Kay; Hinz Burkhard
R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1219-28.
2006: Hinz Burkhard; Dormann Harald; Brune Kay
More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib.
Arthritis and rheumatism 2006;54(1):282-91.
2006: Eichele Karin; Weinzierl Ulrike; Ramer Robert; Brune Kay; Hinz Burkhard
R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells.
Pharmaceutical research 2006;23(1):90-4.
2006: Pahl Andreas; Szelenyi Stefan; Brune Kay
Hypoxia induced chemokine expression in nasal epithelial cells: development of an in vitro model for chronic rhinosinusitis.
ALTEX : Alternativen zu Tierexperimenten 2006;23(2):59-63.
2005: Rösch Susanne; Ramer Robert; Brune Kay; Hinz Burkhard
Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.
Biochemical and biophysical research communications 2005;338(2):1171-8.
2005: Cheremina Olga; Bachmakov Iouri; Neubert Antje; Brune Kay; Fromm Martin F; Hinz Burkhard
Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2005;19(10):777-82.
2005: Hinz Burkhard; Rösch Susanne; Ramer Robert; Tamm Ernst R; Brune Kay
Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(13):1929-31.
2005: Lamprecht Christoph; Werner Ulrike; Werner Dierk; Schaefer Simon; Renner Bertold; Fromm Martin; Brune Kay
Effect of selective cyclooxygenase-2 inhibitors on heart rate in healthy young men.
The American journal of cardiology 2005;95(12):1531-2.
2005: Reinold Heiko; Ahmadi Seifollah; Depner Ulrike B; Layh Beate; Heindl Cornelia; Hamza May; Pahl Andreas; Brune Kay; Narumiya Shuh; Müller Ulrike; Zeilhofer Hanns Ulrich
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype.
The Journal of clinical investigation 2005;115(3):673-9.
2005: Werner Ulrike; Werner Dierk; Hinz Burkhard; Lambrecht Christoph; Brune Kay
A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma.
Biomedical chromatography : BMC 2005;19(2):113-8.
2005: Brune Kay
[Treatment of musculoskeletal pain]
Medizinische Monatsschrift für Pharmazeuten 2005;28(1):19-23.
2005: Hinz Burkhard; Chevts Julia; Renner Bertold; Wuttke Henrike; Rau Thomas; Schmidt Andreas; Szelenyi Istvan; Brune Kay; Werner Ulrike
Bioavailability of diclofenac potassium at low doses.
British journal of clinical pharmacology 2005;59(1):80-4.
2005: Chialda Ligia; Zhang Meixia; Brune Kay; Pahl Andreas
Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia.
Respiratory research 2005;6():36.
2005: Egger Tobias; Dormann Harald; Ahne Gabi; Pahl Andreas; Runge Ulrich; Azaz-Livshits Tanya; Neubert Antje; Criegee-Rieck Manfred; Gassmann Karl G; Brune Kay
Cytochrome p450 polymorphisms in geriatric patients: impact on adverse drug reactions--a pilot study.
Drugs & aging 2005;22(3):265-72.
2004: Hinz Burkhard; Ramer Robert; Eichele Karin; Weinzierl Ulrike; Brune Kay
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells.
Molecular pharmacology 2004;66(6):1643-51.
2004: Werner Dierk; Wuttke Henrike; Fromm Martin F; Schaefer Simon; Eschenhagen Thomas; Brune Kay; Daniel Werner G; Werner Ulrike
Effect of amiodarone on the plasma levels of metoprolol.
The American journal of cardiology 2004;94(10):1319-21.
2004: Hinz Burkhard; Ramer Robert; Eichele Karin; Weinzierl Ulrike; Brune Kay
R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts.
Biochemical and biophysical research communications 2004;324(2):621-6.
2004: Hinz Burkhard; Brune Kay
Pain and osteoarthritis: new drugs and mechanisms.
Current opinion in rheumatology 2004;16(5):628-33.
2004: Brune Kay; Hinz Burkhard
The discovery and development of antiinflammatory drugs.
Arthritis and rheumatism 2004;50(8):2391-9.
2004: Dormann H; Neubert A; Criegee-Rieck M; Egger T; Radespiel-Tröger M; Azaz-Livshits T; Levy M; Brune K; Hahn E G
Readmissions and adverse drug reactions in internal medicine: the economic impact.
Journal of internal medicine 2004;255(6):653-63.
2004: Brune Kay
[New evaluation by the EU approval committee. Benefits of cox-2 inhibitors outweigh possible risks (interview by Dr. Thomas Meissner)]
MMW Fortschritte der Medizin 2004;146(9):47.
2004: Dormann H; Criegee-Rieck M; Neubert A; Egger T; Levy M; Hahn E G; Brune K
Implementation of a computer-assisted monitoring system for the detection of adverse drug reactions in gastroenterology.
Alimentary pharmacology & therapeutics 2004;19(3):303-9.
2004: Brune K
Safety of anti-inflammatory treatment--new ways of thinking.
Rheumatology (Oxford, England) 2004;43 Suppl 1():i16-20.
2004: Neubert Antje; Dormann Harald; Weiss Jutta; Egger Tobias; Criegee-Rieck Manfred; Rascher Wolfgang; Brune Kay; Hinz Burkhard
The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients.
Drug safety : an international journal of medical toxicology and drug experience 2004;27(13):1059-67.
2004: Brune Kay
Replacement and refinement of animal experimentation in drug research has been and will be a permanent and necessary process.
ALTEX : Alternativen zu Tierexperimenten 2004;21(1):38-41.
2003: Ramer Robert; Weinzierl Ulrike; Schwind Bianca; Brune Kay; Hinz Burkhard
Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells.
Molecular pharmacology 2003;64(5):1189-98.
2003: Hinz Burkhard; Rau Thomas; Auge Daniel; Werner Ulrike; Ramer Robert; Rietbrock Stephan; Brune Kay
Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac.
Clinical pharmacology and therapeutics 2003;74(3):222-35.
2003: Werner Ulrike; Werner Dierk; Rau Thomas; Fromm Martin F; Hinz Burkhard; Brune Kay
Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans.
Clinical pharmacology and therapeutics 2003;74(2):130-7.
2003: Schmidt Andreas; Schwind Bianca; Gillich Martin; Brune Kay; Hinz Burkhard
Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2003;17(4):276-81.
2003: Hinz Burkhard; Auge Daniel; Rau Thomas; Rietbrock Stephan; Brune Kay; Werner Ulrike
Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography.
Biomedical chromatography : BMC 2003;17(4):268-75.
2003: Depner Ulrike B; Reinscheid Rainer K; Takeshima Hiroshi; Brune Kay; Zeilhofer Hanns Ulrich
Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor.
The European journal of neuroscience 2003;17(11):2381-7.
2003: Hinz Burkhard; Brune Kay; Pahl Andreas
15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism.
Biochemical and biophysical research communications 2003;302(2):415-20.
2003: Egger Tobias; Dormann Harald; Ahne Gabi; Runge Ulrich; Neubert Antje; Criegee-Rieck Manfred; Gassmann Karl G; Brune Kay
Identification of adverse drug reactions in geriatric inpatients using a computerised drug database.
Drugs & aging 2003;20(10):769-76.
2003: Hinz Burkhard; Ramer Robert; Brune Kay
Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide.
Advances in experimental medicine and biology 2003;525():145-52.
2003: Brune Kay
[Self experimentation and in vitro research will not suffice: a plea for more refinement]
ALTEX : Alternativen zu Tierexperimenten 2003;20(1):48-50.
2003: Dormann Harald; Criegee-Rieck Manfred; Neubert Antje; Egger Tobias; Geise Arnim; Krebs Sabine; Schneider Thomas; Levy Micha; Hahn Eckhart; Brune Kay
Lack of awareness of community-acquired adverse drug reactions upon hospital admission : dimensions and consequences of a dilemma.
Drug safety : an international journal of medical toxicology and drug experience 2003;26(5):353-62.
2002: Pahl Andreas; Brune Kay
Stabilization of gene expression profiles in blood after phlebotomy.
Clinical chemistry 2002;48(12):2251-3.
2002: Gühring Hans; Hamza May; Sergejeva Marina; Ates Mehmet; Kotalla Carolin E; Ledent Catherine; Brune Kay
A role for endocannabinoids in indomethacin-induced spinal antinociception.
European journal of pharmacology 2002;454(2-3):153-63.
2002: Schmitt Christopher; Humeny Andreas; Becker Cord-Michael; Brune Kay; Pahl Andreas
Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles.
Clinical chemistry 2002;48(10):1661-7.
2002: Weiss Jutta; Krebs Sabine; Hoffmann Claudia; Werner Ulrike; Neubert Antje; Brune Kay; Rascher Wolfgang
Survey of adverse drug reactions on a pediatric ward: a strategy for early and detailed detection.
Pediatrics 2002;110(2 Pt 1):254-7.
2002: Schuster Johannes; Ates Mehmet; Brune Kay; Gühring Hans
The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU-210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.
Neuroscience letters 2002;326(3):196-200.
2002: Pahl Andreas; Zhang Meixia; Török Katalin; Kuss Hildegard; Friedrich Ute; Magyar Zoltan; Szekely Jozsef; Horvath Katalin; Brune Kay; Szelenyi Istvan
Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787.
The Journal of pharmacology and experimental therapeutics 2002;301(2):738-46.
2002: Szelenyi Istvan; Brune Kay
Herbal remedies for asthma treatment: between myth and reality.
Drugs of today (Barcelona, Spain : 1998) 2002;38(4):265-303.
2002: Pahl Andreas; Zhang Meixia; Kuss Hildegard; Szelenyi Istvan; Brune Kay
Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy.
British journal of pharmacology 2002;135(8):1915-26.
2002: Werner Ulrike; Werner Dierk; Pahl Andreas; Mundkowski Ralf; Gillich Martin; Brune Kay
Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry.
Biomedical chromatography : BMC 2002;16(1):56-60.
2002: Hinz Burkhard; Brune Kay
Cyclooxygenase-2--10 years later.
The Journal of pharmacology and experimental therapeutics 2002;300(2):367-75.
2002: Brune Kay
Animal experimentation in sciences: sadistic nonsense or indispensable necessity?
ALTEX : Alternativen zu Tierexperimenten 2002;19(3):130-6.
2002: Brune Kay; Egger Tobias
[World-wide sales power of a drug group! The evolution of antipyretic analgesics]
Pharmazie in unserer Zeit 2002;31(2):133-9.
2001: Gühring H; Schuster J; Hamza M; Ates M; Kotalla C E; Brune K
HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test.
European journal of pharmacology 2001;429(1-3):127-34.
2001: Lötsch J; Muth-Selbach U; Tegeder I; Brune K; Geisslinger G
Simultaneous fitting of R- and S-ibuprofen plasma concentrations after oral administration of the racemate.
British journal of clinical pharmacology 2001;52(4):387-98.
2001: Maihöfner C; Schlötzer-Schrehardt U; Gühring H; Zeilhofer H U; Naumann G O; Pahl A; Mardin C; Tamm E R; Brune K
Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes.
Investigative ophthalmology & visual science 2001;42(11):2616-24.
2001: Ramer R; Brune K; Pahl A; Hinz B
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Biochemical and biophysical research communications 2001;286(5):1144-52.
2001: Werner U; Werner D; Mundkowski R; Gillich M; Brune K
Selective and rapid liquid chromatography-mass spectrometry method for the quantification of rofecoxib in pharmacokinetic studies with humans.
Journal of chromatography. B, Biomedical sciences and applications 2001;760(1):83-90.
2001: Damm J; Rau T; Maihöfner C; Pahl A; Brune K
Constitutive expression and localization of COX-1 and COX-2 in rabbit iris and ciliary body.
Experimental eye research 2001;72(6):611-21.
2001: Tegeder I; Niederberger E; Israr E; Gühring H; Brune K; Euchenhofer C; Grösch S; Geisslinger G
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(3):595-7.
2001: Bruggera R; Reichel C; Garcia Alia B; Brune K; Yamamoto T; Tegeder I; Geisslinger G;
Expression of rat liver long-chain acyl-CoA synthetase and characterization of its role in the metabolism of R-ibuprofen and other fatty acid-like xenobiotics.
Biochemical pharmacology 2001;61(6):651-6.
2001: Hinz B; Brune K; Rau T; Pahl A
Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages.
Pharmaceutical research 2001;18(2):151-6.
2001: Gühring H; Tegeder I; Lötsch J; Pahl A; Werner U; Reeh P W; Rehse K; Brune K; Geisslinger G
Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2001;50(2):83-8.
2001: Dormann H; Krebs S; Muth-Selbach U; Criegee-Rieck M; Radespiel-Tröger M; Levy M; Hahn E G; Brune K; Schneider H T
Adverse drug reactions in patients with gastroenterological diseases: does age increase the risk?
Alimentary pharmacology & therapeutics 2001;15(2):171-80.
2001: Krebs S; Dormann H; Muth-Selbach U; Hahn E G; Brune K; Schneider H T
Risperidone-induced cholestatic hepatitis.
European journal of gastroenterology & hepatology 2001;13(1):67-9.
2001: Tegeder I; Niederberger E; Israr E; Gühring H; Brune K; Euchenhofer C; Grösch S; Geisslinger G
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):2-4.
2001: Sommerauer M; Ates M; Gühring H; Brune K; Amann R; Peskar B A
Ketoprofen-induced cyclooxygenase inhibition in renal medulla and platelets of rats treated with caffeine.
Pharmacology 2001;63(4):234-9.
2000: Werner U; Brune K; Layh B; Guehring H
Determination of L-iminoethyl-L-lysine in serum by liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;749(1):35-40.
2000: Hinz B; Brune K; Pahl A
Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugs.
Biochemical and biophysical research communications 2000;278(3):790-6.
2000: Grosser K; Oelkers R; Hummel T; Geisslinger G; Brune K; Kobal G; Lötsch J
Olfactory and trigeminal event-related potentials in migraine.
Cephalalgia : an international journal of headache 2000;20(7):621-31.
2000: Gühring H; Görig M; Ates M; Coste O; Zeilhofer H U; Pahl A; Rehse K; Brune K
Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(17):6714-20.
2000: Krebs S; Dormann H; Hahn E G; Schneider H T; Brune K
[Adverse drug effects. Prevention, detection and early intervention by a computer-assisted early warning system]
Deutsche medizinische Wochenschrift (1946) 2000;125(33):984-7.
2000: Hartner A; Pahl A; Brune K; Goppelt-Struebe M
Upregulation of cyclooxygenase-1 and the PGE2 receptor EP2 in rat and human mesangioproliferative glomerulonephritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2000;49(7):345-54.
2000: Hinz B; Kraus V; Pahl A; Brune K
Salicylate metabolites inhibit cyclooxygenase-2-dependent prostaglandin E(2) synthesis in murine macrophages.
Biochemical and biophysical research communications 2000;274(1):197-202.
2000: Hinz B; Brune K; Pahl A
Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Biochemical and biophysical research communications 2000;272(3):744-8.
2000: Bang H; Pecht A; Raddatz G; Scior T; Solbach W; Brune K; Pahl A
Prolyl isomerases in a minimal cell. Catalysis of protein folding by trigger factor from Mycoplasma genitalium.
European journal of biochemistry / FEBS 2000;267(11):3270-80.
2000: Geisslinger G; Muth-Selbach U; Coste O; Vetter G; Schrödter A; Schaible H G; Brune K; Tegeder I
Inhibition of noxious stimulus-induced spinal prostaglandin E2 release by flurbiprofen enantiomers: a microdialysis study.
Journal of neurochemistry 2000;74(5):2094-100.
2000: Hinz B; Brune K; Pahl A
Nitric oxide inhibits inducible nitric oxide synthase mRNA expression in RAW 264.7 macrophages.
Biochemical and biophysical research communications 2000;271(2):353-7.
2000: Hinz B; Brune K
[Gastric protective pain therapy. What is the advantage of new COX-2 inhibitors?]
MMW Fortschritte der Medizin 2000;142(11):39-40.
2000: Dormann H; Muth-Selbach U; Krebs S; Criegee-Rieck M; Tegeder I; Schneider H T; Hahn E G; Levy M; Brune K; Geisslinger G
Incidence and costs of adverse drug reactions during hospitalisation: computerised monitoring versus stimulated spontaneous reporting.
Drug safety : an international journal of medical toxicology and drug experience 2000;22(2):161-8.
2000: Lötsch J; Kettenmann B; Renner B; Drover D; Brune K; Geisslinger G; Kobal G
Population pharmacokinetics of fast release oral diclofenac in healthy volunteers: relation to pharmacodynamics in an experimental pain model.
Pharmaceutical research 2000;17(1):77-84.
2000: Maihöfner C; Tegeder I; Euchenhofer C; deWitt D; Brune K; Bang R; Neuhuber W; Geisslinger G
Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord.
Neuroscience 2000;101(4):1093-108.
1999: Muth-Selbach U S; Tegeder I; Brune K; Geisslinger G
Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation.
Anesthesiology 1999;91(1):231-9.
1999: Oelkers R; Grosser K; Lang E; Geisslinger G; Kobal G; Brune K; Lötsch J
Visual evoked potentials in migraine patients: alterations depend on pattern spatial frequency.
Brain : a journal of neurology 1999;122 ( Pt 6)():1147-55.
1999: Tegeder I; Lötsch J; Krebs S; Muth-Selbach U; Brune K; Geisslinger G
Comparison of inhibitory effects of meloxicam and diclofenac on human thromboxane biosynthesis after single doses and at steady state.
Clinical pharmacology and therapeutics 1999;65(5):533-44.
1999: Tegeder I; Levy M; Muth-Selbach U; Oelkers R; Neumann F; Dormann H; Azaz-Livshits T; Criegee-Rieck M; Schneider H T; Hahn E; Brune K; Geisslinger G
Retrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals.
British journal of clinical pharmacology 1999;47(5):557-64.
1999: Tegeder I; Muth-Selbach U; Lötsch J; Rüsing G; Oelkers R; Brune K; Meller S; Kelm G R; Sörgel F; Geisslinger G
Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration.
Clinical pharmacology and therapeutics 1999;65(4):357-68.
1999: Hinz B; Brune K
[Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances]
Wiener klinische Wochenschrift 1999;111(3):103-12.
1999: Hinz B; Brune K
[COX-1 and COX-2: functions and pharmacological effects]
Pharmazie in unserer Zeit 1999;28(1):21-9.
1999: Tegeder I; Neumann F; Bremer F; Brune K; Lötsch J; Geisslinger G
Pharmacokinetics of meropenem in critically ill patients with acute renal failure undergoing continuous venovenous hemofiltration.
Clinical pharmacology and therapeutics 1999;65(1):50-7.
1998: Brune K; Hinz B
[2-Arylpropionic acids. Role in pain therapy]
Schmerz (Berlin, Germany) 1998;12(6):383-8.
1998: Beiche F; Brune K; Geisslinger G; Goppelt-Struebe M
Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1998;47(12):482-7.
1998: Rascher C; Pahl A; Pecht A; Brune K; Solbach W; Bang H
Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin.
The Biochemical journal 1998;334 ( Pt 3)():659-67.
1998: Euchenhofer C; Maihófner C; Brune K; Tegeder I; Geisslinger G
Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.
Neuroscience letters 1998;248(1):25-8.
1998: Scheuerer S; Williams K M; Brugger R; McLachlan A J; Brune K; Day R O; Geisslinger G
Effect of clofibrate on the chiral disposition of ibuprofen in rats.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1132-8.
1998: Scheuren N; Bang H; Münster T; Brune K; Pahl A
Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen.
British journal of pharmacology 1998;123(4):645-52.
1997: Tegeder I; Bremer F; Oelkers R; Schobel H; Schüttler J; Brune K; Geisslinger G
Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration.
Antimicrobial agents and chemotherapy 1997;41(12):2640-5.
1997: Lötsch J; Kobal G; Stockmann A; Brune K; Geisslinger G
Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers.
Anesthesiology 1997;87(6):1348-58.
1997: Neupert W; Brugger R; Euchenhofer C; Brune K; Geisslinger G
Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases.
British journal of pharmacology 1997;122(3):487-92.
1997: Tegeder I; Schumacher A; John S; Geiger H; Geisslinger G; Bang H; Brune K
Elevated serum cyclophilin levels in patients with severe sepsis.
Journal of clinical immunology 1997;17(5):380-6.
1997: Pahl A; Brune K; Bang H
Fit for life? Evolution of chaperones and folding catalysts parallels the development of complex organisms.
Cell stress & chaperones 1997;2(2):78-86.
1997: Erb K; Liebel J T; Tegeder I; Zeilhofer H U; Brune K; Geisslinger G
Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test.
Neuroreport 1997;8(8):1967-70.
1997: Hoerauf A; Rascher C; Bang R; Pahl A; Solbach W; Brune K; Röllinghoff M; Bang H
Host-cell cyclophilin is important for the intracellular replication of Leishmania major.
Molecular microbiology 1997;24(2):421-9.
1997: Geisslinger G; Brune K; Kobal G; Lötsch J
Intravenous morphine-6-glucuronide (M6G) is devoid of analgesic activity in man.
Pain 1997;70(2-3):289-90.
1997: Reichel C; Brugger R; Bang H; Geisslinger G; Brune K
Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: a key enzyme in the inversion metabolism of ibuprofen.
Molecular pharmacology 1997;51(4):576-82.
1997: Oelkers R; Neupert W; Williams K M; Brune K; Geisslinger G
Disposition and effects of flurbiprofen enantiomers in human serum and blister fluid.
British journal of clinical pharmacology 1997;43(2):145-53.
1997: Scheuren N; Bang H; Münster T; Brune K; Pahl A
Weak inhibitors of cyclooxygenases may exert their antinociceptive effect by modulation of transcription factors.
Advances in experimental medicine and biology 1997;433():51-4.
1997: Scheuren N; Neupert W; Ionac M; Neuhuber W; Brune K; Geisslinger G
Peripheral noxious stimulation releases spinal PGE2 during the first phase in the formalin assay of the rat.
Life sciences 1997;60(21):PL 295-300.
1996: Neupert W; Oelkers R; Brune K; Geisslinger G
A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate.
Prostaglandins 1996;52(5):385-401.
1996: Geisslinger G; Peskar B A; Pallapies D; Sittl R; Levy M; Brune K
The effects on platelet aggregation and prostanoid biosynthesis of two parenteral analgesics: ketorolac tromethamine and dipyrone.
Thrombosis and haemostasis 1996;76(4):592-7.
1996: Oelkers R; Ionac M; Erb K; Brune K; Geisslinger G
Transfer of different nonsteroidal antiinflammatory drugs via the lymphatic system in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(10):1107-10.
1996: Brugger R; García Alía B; Reichel C; Waibel R; Menzel S; Brune K; Geisslinger G
Isolation and characterization of rat liver microsomal R-ibuprofenoyl-CoA synthetase.
Biochemical pharmacology 1996;52(7):1007-13.
1996: Lötsch J; Stockmann A; Kobal G; Brune K; Waibel R; Schmidt N; Geisslinger G
Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers.
Clinical pharmacology and therapeutics 1996;60(3):316-25.
1996: Ionac M; Oelkers R; Brune K; Geisslinger G; Bordos D
Lymph distribution of different non-steroidal anti-inflammatory drugs assessed by microsurgical cannulation of the thoracic duct in rat.
Romanian journal of internal medicine = Revue roumaine de médecine interne 1996;34(3-4):239-51.
1996: Beiche F; Scheuerer S; Brune K; Geisslinger G; Goppelt-Struebe M
Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation.
FEBS letters 1996;390(2):165-9.
1996: Ionac M; Parnham M J; Plauchithiu M; Brune K
Oxaceprol, an atypical inhibitor of inflammation and joint damage.
Pharmacological research : the official journal of the Italian Pharmacological Society 1996;33(6):367-73.
1996: Ionac M; Bordos D; Geisslinger G; Brune K
[An experimental model of the microsurgical cannulation of the thoracic duct in the rat]
Chirurgia (Bucharest, Romania : 1990) 1996;45(3):147-9.
1996: Ionac M; Geisslinger G; Brune K; Bordos D
[A microsurgical approach to drainage of the thoracic duct in the rat]
Revista medico-chirurgicala? a Societa?t?ii de Medici s¸i Naturalis¸ti din Ias¸i 1996;100(1-2):112-7.
1996: Geisslinger G; Menzel S; Brune K
Stereospecific determination of tiaprofenic acid in plasma: problems with drug degradation.
Journal of chromatography. B, Biomedical applications 1996;675(1):77-81.
1995: Lötsch J; Mohammadian P; Hummel T; Florin S; Brune K; Geisslinger G; Kobal G
Effects of azapropazone on pain-related brain activity in human subjects.
British journal of clinical pharmacology 1995;40(6):545-52.
1995: Reichel C; Bang H; Brune K; Geisslinger G; Menzel S
2-Arylpropionyl-CoA epimerase: partial peptide sequences and tissue localization.
Biochemical pharmacology 1995;50(11):1803-6.
1995: Lötsch J; Geisslinger G; Mohammadian P; Brune K; Kobal G
Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects.
British journal of clinical pharmacology 1995;40(4):339-46.
1995: Ernst H; Grunert S; Schneider H T; Beck W S; Brune K; Hahn E G
Distribution of extracellular matrix proteins in indomethacin-induced lesions in the rat stomach.
Scandinavian journal of gastroenterology 1995;30(9):847-53.
1995: Kilo S; Forster C; Geisslinger G; Brune K; Handwerker H O
Inflammatory models of cutaneous hyperalgesia are sensitive to effects of ibuprofen in man.
Pain 1995;62(2):187-93.
1995: Krummrei U; Bang R; Schmidtchen R; Brune K; Bang H
Cyclophilin-A is a zinc-dependent DNA binding protein in macrophages.
FEBS letters 1995;371(1):47-51.
1995: Geisslinger G; Menzel S; Wissel K; Brune K
Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate.
British journal of clinical pharmacology 1995;40(1):73-5.
1995: Hering W; Schlecht R; Geisslinger G; Biburger G; Dinkel M; Brune K; Rügheimer E
EEG analysis and pharmacodynamic modelling after intravenous bolus injection of eltanolone (pregnanolone).
European journal of anaesthesiology 1995;12(4):407-15.
1994: Pallapies D; Peskar B A; Brune K; Zeilhofer H U
Modulation of nitric oxide effects by flurbiprofen enantiomers and nefopam and its relation to antinociception.
European journal of pharmacology 1994;271(2-3):335-40.
1994: Hering W; Geisslinger G; Kamp H D; Dinkel M; Tschaikowsky K; Rügheimer E; Brune K
Changes in the EEG power spectrum after midazolam anaesthesia combined with racemic or S- (+) ketamine.
Acta anaesthesiologica Scandinavica 1994;38(7):719-23.
1994: Menzel S; Waibel R; Brune K; Geisslinger G
Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion?
Biochemical pharmacology 1994;48(5):1056-8.
1994: Schmidt N; Brune K; Geisslinger G
Opioid receptor agonist potencies of morphine and morphine-6-glucuronide in the guinea-pig ileum.
European journal of pharmacology 1994;255(1-3):245-7.
1994: Geisslinger G; Lötsch J; Menzel S; Kobal G; Brune K
Stereoselective disposition of flurbiprofen in healthy subjects following administration of the single enantiomers.
British journal of clinical pharmacology 1994;37(4):392-4.
1994: Pallapies D; Peskar B A; Brune K; Geisslinger G
Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses.
British journal of clinical pharmacology 1994;37(4):335-9.
1994: Menzel S; Sauernheimer C; Brune K; Geisslinger G
Is the inversion from R- to S-ketoprofen concentration dependent? Investigations in rats in vivo and in vitro.
Biochemical pharmacology 1994;47(7):1267-70.
1994: Geisslinger G; Ferreira S H; Menzel S; Schlott D; Brune K
Antinociceptive actions of R(-)-flurbiprofen--a non-cyclooxygenase inhibiting 2-arylpropionic acid--in rats.
Life sciences 1994;54(10):PL173-7.
1994: Feige U; Schulmeister A; Mollenhauer J; Brune K; Bang H
A constitutive 65 kDa chondrocyte protein as a target antigen in adjuvant arthritis in Lewis rats.
Autoimmunity 1994;17(3):233-9.
1994: Schmidt N; Brune K; Williams K M; Geisslinger G
Stereoselective pharmacokinetics of methadone in beagle dogs.
Chirality 1994;6(6):492-5.
1994: Brune K
Spinal cord effects of antipyretic analgesics.
Drugs 1994;47 Suppl 5():21-7; discussion 46-7.
1993: Bang H; Brune K; Nager C; Feige U
Interleukin-8 is a cyclosporin A binding protein.
Experientia 1993;49(6-7):533-8.
1993: Geisslinger G; Stock K P; Loew D; Bach G L; Brune K
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.
British journal of clinical pharmacology 1993;35(6):603-7.
1993: Geisslinger G; Hering W; Thomann P; Knoll R; Kamp H D; Brune K
Pharmacokinetics and pharmacodynamics of ketamine enantiomers in surgical patients using a stereoselective analytical method.
British journal of anaesthesia 1993;70(6):666-71.
1993: van Hilten J A; Brune K; Bickel D; Mollenhauer J
Characterization of macrophage proteins bearing the functional leukotriene D4-binding site of an anti-cysteinylleukotriene monoclonal antibody.
European journal of biochemistry / FEBS 1993;214(1):83-90.
1993: Schmidt N; Sittl R; Brune K; Geisslinger G
Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring.
Pharmaceutical research 1993;10(3):441-4.
1993: Mann J F; Goerig M; Brune K; Luft F C
Ibuprofen as an over-the-counter drug: is there a risk for renal injury?
Clinical nephrology 1993;39(1):1-6.
1993: Menzel S; Beck W S; Brune K; Geisslinger G
Stereoselectivity of biliary excretion of 2-arylpropionates in rats.
Chirality 1993;5(6):422-7.
1993: Menzel-Soglowek S; Geisslinger G; Brune K
Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines.
Agents and actions. Supplements 1993;44():23-9.
1993: Brune K; Nuernberg B; Schneider H T
Biliary elimination of aspirin after oral and intravenous administration in patients.
Agents and actions. Supplements 1993;44():51-7.
1993: Geisslinger G; Menzel-Soglowek S; Beck W S; Brune K
R-flurbiprofen: isomeric ballast or active entity of the racemic compound?
Agents and actions. Supplements 1993;44():31-6.
1992: Schmidt N; Brune K; Geisslinger G
Stereoselective determination of the enantiomers of methadone in plasma using high-performance liquid chromatography.
Journal of chromatography 1992;583(2):195-200.
1992: Brune K; Geisslinger G; Menzel-Soglowek S
Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology.
Journal of clinical pharmacology 1992;32(10):944-52.
1992: Menzel-Soglowek S; Geisslinger G; Beck W S; Brune K
Variability of inversion of (R)-flurbiprofen in different species.
Journal of pharmaceutical sciences 1992;81(9):888-91.
1992: Menzel-Soglowek S; Geisslinger G; Mollenhauer J; Brune K
Metabolic chiral inversion of 2-arylpropionates in rat H4IIE and human Hep G2 hepatoma cells. Relationship to in vivo metabolism.
Biochemical pharmacology 1992;43(7):1487-92.
1992: Zeilhofer H U; Swandulla D; Geisslinger G; Brune K
Differential effects of ketamine enantiomers on NMDA receptor currents in cultured neurons.
European journal of pharmacology 1992;213(1):155-8.
1992: Mettal D; Brune K; Mollenhauer J
Cytotoxic effects of rheumatoid arthritis sera on chondrocytes.
Biochimica et biophysica acta 1992;1138(2):85-92.
1992: Geisslinger G; Menzel-Soglowek S; Schuster O; Brune K
Stereoselective high-performance liquid chromatographic determination of flurbiprofen in human plasma.
Journal of chromatography 1992;573(1):163-7.
1992: Brune K; Menzel-Soglowek S; Zeilhofer H U
Differential analgesic effects of aspirin-like drugs.
Drugs 1992;44 Suppl 5():52-8; discussion 58-9.
1991: Peskar B M; Kluge S; Peskar B A; Soglowek S M; Brune K
Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo.
Prostaglandins 1991;42(6):515-31.
1991: Geisslinger G; Menzel-Soglowek S; Kamp H D; Brune K
Stereoselective high-performance liquid chromatographic determination of the enantiomers of ketamine and norketamine in plasma.
Journal of chromatography 1991;568(1):165-76.
1991: Brune K; Beck W S; Geisslinger G; Menzel-Soglowek S; Peskar B M; Peskar B A
Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition.
Experientia 1991;47(3):257-61.
1991: Reinke M; Hoppe U; Röder T; Bestmann H J; Mollenhauer J; Brune K
A monoclonal antibody against the sulfidopeptide leukotrienes LTC4, LTD4 and LTE4.
Biochimica et biophysica acta 1991;1081(3):274-8.
1991: Nuernberg B; Koehler G; Brune K
Pharmacokinetics of diflunisal in patients.
Clinical pharmacokinetics 1991;20(1):81-9.
1991: Brune K; Beck W S
Towards safer nonsteroidal anti-inflammatory drugs.
Agents and actions. Supplements 1991;32():13-25.
1991: Beck W S; Geisslinger G; Engler H; Brune K
Pharmacokinetics of ibuprofen enantiomers in dogs.
Chirality 1991;3(3):165-9.
1991: Stock K P; Geisslinger G; Loew D; Beck W S; Bach G L; Brune K
S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritis.
Rheumatology international 1991;11(4-5):199-202.
1990: Menzel-Soglowek S; Geisslinger G; Brune K
Stereoselective high-performance liquid chromatographic determination of ketoprofen, ibuprofen and fenoprofen in plasma using a chiral alpha 1-acid glycoprotein column.
Journal of chromatography 1990;532(2):295-303.
1990: Beck W S; Dietzel K; Geisslinger G; Engler H; Vergin H; Brune K
Effects of sodium salicylate on elimination kinetics of indomethacin and bile production in dogs.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):962-7.
1990: Nuernberg B; Szelenyi I; Schneider H T; Brune K
Diflunisal disposition. Role of gastric absorption in the development of mucosal damage and anti-inflammatory potency in rodents.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(6):937-42.
1990: Moeller N; Dietzel K; Nuernberg B; Geisslinger G; Brune K
High-performance liquid chromatographic determination of pentazocine in plasma.
Journal of chromatography 1990;530(1):200-5.
1990: Jurna I; Brune K
Central effect of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen, and diclofenac, determined in C fibre-evoked activity in single neurones of the rat thalamus.
Pain 1990;41(1):71-80.
1990: Kobal G; Hummel C; Nuernberg B; Brune K
Effects of pentazocine and acetylsalicylic acid on pain-rating, pain-related evoked potentials and vigilance in relationship to pharmacokinetic parameters.
Agents and actions 1990;29(3-4):342-59.
1990: Enzmann H; Mollenhauer J; Brune K
Humoral autoimmunity to cartilage in rheumatoid arthritis?
Agents and actions 1990;29(1-2):114-6.
1990: Dietzel K; Beck W S; Schneider H T; Geisslinger G; Brune K
The biliary elimination and enterohepatic circulation of ibuprofen in rats.
Pharmaceutical research 1990;7(1):87-90.
1990: Schneider H T; Nuernberg B; Dietzel K; Brune K
Biliary elimination of non-steroidal anti-inflammatory drugs in patients.
British journal of clinical pharmacology 1990;29(1):127-31.
1990: Geisslinger G; Schuster O; Stock K P; Loew D; Bach G L; Brune K
Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis.
European journal of clinical pharmacology 1990;38(5):493-7.
1990: Brune K
Is there a rational basis for the different spectra of adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs)?
Drugs 1990;40 Suppl 5():12-5.
1990: Beck W S; Schneider H T; Dietzel K; Nuernberg B; Brune K
Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved.
Archives of toxicology 1990;64(3):210-7.
1989: Geisslinger G; Dietzel K; Bezler H; Nuernberg B; Brune K
Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid.
International journal of clinical pharmacology, therapy, and toxicology 1989;27(7):324-8.
1989: Geisslinger G; Stock K P; Bach G L; Loew D; Brune K
Pharmacological differences between R(-)- and S(+)-ibuprofen.
Agents and actions 1989;27(3-4):455-7.
1989: Geisslinger G; Dietzel K; Loew D; Schuster O; Rau G; Lachmann G; Brune K
High-performance liquid chromatographic determination of ibuprofen, its metabolites and enantiomers in biological fluids.
Journal of chromatography 1989;491(1):139-49.
1989: Reinke M; Piller M; Brune K
Development of an enzyme-linked immunosorbent assay of thromboxane B2 using a monoclonal antibody.
Prostaglandins 1989;37(5):577-86.
1989: Brune K
Ten years research on inflammation revisited.
Agents and actions 1989;26(1-2):4-8.
1989: Zeilhofer H U; Mollenhauer J; Brune K
Selective growth inhibition of ductal pancreatic adenocarcinoma cells by the lysosomotropic agent chloroquine.
Cancer letters 1989;44(1):61-6.
1988: Reinke M; Brune K
A monoclonal anti-thromboxane B2 antibody.
FEBS letters 1988;232(1):46-50.
1988: Mollenhauer J; Brune K
Detection of autoimmunoreactive antibodies against cartilage cell surface proteins in the blood of rheumatic patients.
Agents and actions 1988;23(1-2):48-9.
1988: Brune K
The pharmacological profile of non-opioid (OTC) analgesics: aspirin, paracetamol (acetaminophen), ibuprofen, and phenazones.
Agents and actions. Supplements 1988;25():9-19.
1987: Brune K; Dietzel K; Nürnberg B; Schneider H T
Recent insight into the mechanism of gastrointestinal tract ulceration.
European journal of rheumatology and inflammation 1987;9(2):8-14.
1987: Brune K; Dietzel K; Nürnberg B; Schneider H T
Recent insight into the mechanism of gastrointestinal tract ulceration.
Scandinavian journal of rheumatology. Supplement 1987;65():135-40.

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