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Alan Ashworth

Research Profile

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TOP 3
Sari Neijenhuis; Ilirjana Bajrami; Christopher J Lord; Rowan Miller; Alan Ashworth
Identification of miRNA modulators to PARP inhibitor response.
Louise J Barber; James Campbell; Lina Chen; Johann De Bono; Kerry Fenwick; Stan Kaye; Iwanka Kozarewa; christopher Lord; Joaquin Mateo; L Rhoda Molife; Victor Moreno; Daniel Nava Rodrigues; Shahneen Sandhu; Jorge S Reis Filho; Ioannis Assiotis; Alan Ashworth
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor.
Stephen J Pettitt; Farah L Rehman; Fredrik Wallberg; Ioannis Assiotis; Ilirjana Bajrami; Rachel Brough; James Campbell; Lina Chen; Kerry Fenwick; Iwanka Kozarewa; christopher Lord; Alan Ashworth
A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity.

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All Publications

2013: Sari Neijenhuis; Ilirjana Bajrami; Christopher J Lord; Rowan Miller; Alan Ashworth
Identification of miRNA modulators to PARP inhibitor response.
DNA repair 2013;12(6):394-402.
2013: Louise J Barber; James Campbell; Lina Chen; Johann De Bono; Kerry Fenwick; Stan Kaye; Iwanka Kozarewa; christopher Lord; Joaquin Mateo; L Rhoda Molife; Victor Moreno; Daniel Nava Rodrigues; Shahneen Sandhu; Jorge S Reis Filho; Ioannis Assiotis; Alan Ashworth
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor.
The Journal of pathology 2013;229(3):422-9.
2013: Stephen J Pettitt; Farah L Rehman; Fredrik Wallberg; Ioannis Assiotis; Ilirjana Bajrami; Rachel Brough; James Campbell; Lina Chen; Kerry Fenwick; Iwanka Kozarewa; christopher Lord; Alan Ashworth
A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity.
PloS one 2013;8(4):e61520.
2012: Jenna L Riffell; christopher Lord; Alan Ashworth
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family.
Nature reviews. Drug discovery 2012;11(12):923-36.
2012: Farah L Rehman; christopher Lord; Alan Ashworth
The promise of combining inhibition of PI3K and PARP as cancer therapy.
Cancer discovery 2012;2(11):982-4.
2012: Ilirjana Bajrami; Rachel Brough; Jessica Frankum; Asha Kigozi; christopher Lord; Antoinette Van Weverwijk; Alan Ashworth
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells.
EMBO molecular medicine 2012;4(10):1087-96.
2012: Simon S McDade; Constantinos Mitsopoulos; Nicholas Orr; Daksha Patel; Geraldine P Pivato; Marketa Zvelebil; Alan Ashworth; Ioannis Assiotis; Kerry Fenwick; Jarle Hakas; Alexandra E Henry; Iwanka Kozarewa; christopher Lord; Dennis J McCance
Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.
Nucleic acids research 2012;40(15):7190-206.
2012: Elizabeth Jane Iorns; Clare M Isacke; Anna Jegg; Iwanka Kozarewa; Alan Ashworth; Sonja Dean; Kerry Fenwick; Harry Hnatyszyn; Christopher J Lord; Costas Mitsopoulos; Nirupa Murugaesu; Cristina Naceur-Lombarelli; Mark D Pegram; David Sims; Dafydd Thomas; Toby M Ward; Marketa Zvelebil; Marc Lippman
Whole genome in vivo RNAi screening identifies the leukemia inhibitory factor receptor as a novel breast tumor suppressor.
Breast cancer research and treatment 2012;135(1):79-91.
2012: Simon J Furney; Jarle Hakas; Meenhard Herlyn; Iwanka Kozarewa; Maryou B K Lambros; christopher Lord; Alan Mackay; Costas Mitsopoulos; Hiroshi Murata; Jorge S Reis-Filho; Gerda Ricken; Samra Turajlic; Marketa Zvelebil; Alan Ashworth; Kerry Fenwick; Richard Marais
Genomic characterisation of acral melanoma cell lines.
Pigment cell & melanoma research 2012;25(4):488-92.
2012: Marieke Aarts; Alan Ashworth; Isaac Garcia-Murillas; Heidrun Gevensleben; Melissa S Hurd; Rachel Sharpe; Stuart D Shumway; Carlo Toniatti; Nicholas C Turner
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Cancer discovery 2012;2(6):524-39.
2012: Nichola Johnson; Michael Jones; Michael Kerin; Nick Orr; Claire Palles; Julian Peto; Gillian Ross; Elinor Sawyer; Minouk J Schoemaker; Gemma Simpson; Anthony Swerdlow; Katarzyna Tomczyk; Ian P Tomlinson; Kate Walker; Jill Williamson; Marketa Zvelebil; Alan Ashworth; Peter Broderick; Sarah Chilcott-Burns; Ben Coupland; Isabel dos Santos Silva; Mitch Dowsett; Elizabeth Folkerd; Lorna J Gibson; Ben Haynes; Stephen G Hillier; Richard S Houlston; Olivia Fletcher
CYP3A variation, premenopausal estrone levels, and breast cancer risk.
Journal of the National Cancer Institute 2012;104(9):657-69.
2012: Kevin Brennan; Robert Brown; Francoise Clavel-Chapelon; Miren Dorronsoro; Alan Ashworth; Olivia Fletcher; Montserrat Garcia-Closas; Michael Jones; Rudolf Kaaks; Kay-Tee Khaw; N Charlotte Onland-Moret; Nick Orr; Salvatore Panico; Elio Riboli; Anthony Swerdlow; Heather Thorne; Dimitrios Trichopoulos; Paolo Vineis; James M Flanagan
Intragenic ATM methylation in peripheral blood DNA as a biomarker of breast cancer risk.
Cancer research 2012;72(9):2304-13.
2012: Alan Ashworth
An interview with Pharmacogenomics for the breast cancer special focus issue.
Pharmacogenomics 2012;13(6):651-4.
2012: Ana M Mendes-Pereira; Costas Mitsopoulos; David Sims; Marketa Zvelebil; Ioannis Assiotis; Tim Dexter; Kerry Fenwick; Jarle Hakas; Iwanka Kozarewa; christopher Lord; Alan Ashworth
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2730-5.
2012: Samra Turajlic; Marketa Zvelebil; Costas Mitsopoulos; Jorge S Reis-Filho; Gordon Stamp; Meirion Thomas; Alan Ashworth; Simon J Furney; Felipe C Geyer; Jarle Hakas; Iwanka Kozarewa; Maryou B K Lambros; James Larkin; christopher Lord; Alan Mackay; Richard Marais
Whole genome sequencing of matched primary and metastatic acral melanomas.
Genome research 2012;22(2):196-207.
2012: Felipe C Geyer; Ivana Kurelac; Maryou B K Lambros; Maria A Lopez-Garcia; Alan Mackay; Rachael Natrajan; Moira Ragazzi; Jorge S Reis-Filho; Alan Ashworth; Dario de Biase; Vincenzo Eusebi; Giuseppe Gasparre; Giovanni Tallini
Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology.
Breast cancer research and treatment 2012;132(1):15-28.
2012: Yussanne P Ma; Bianca Olver; Nicola S Russell; Flora E van Leeuwen; Alan Ashworth; Peter Broderick; Annegien Broeks; Rosie Cooke; Victor Enciso-Mora; Richard S Houlston; Cecile Janus; Amy Lloyd; Anthony J Swerdlow
FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma.
Blood 2012;119(4):1029-31.
2012: christopher Lord; Alan Ashworth
The DNA damage response and cancer therapy.
Nature 2012;481(7381):287-94.
2012: Ana M Mendes-Pereira; christopher Lord; Alan Ashworth
NLK is a novel therapeutic target for PTEN deficient tumour cells.
PloS one 2012;7(10):e47249.
2012: Iwanka Kozarewa; Costas Mitsopoulos; Gareth J Morgan; Juan Manuel Rosa-Rosa; Brian A Walker; Christopher P Wardell; Marketa Zvelebil; Christopher J Lord; Alan Ashworth; Ioannis Assiotis; Kerry Fenwick; Christopher J
A modified method for whole exome resequencing from minimal amounts of starting DNA.
PloS one 2012;7(3):e32617.
2011: Anthony J Swerdlow; D Thomas; J Williamson; J Hemming; M E Jones; Minouk J Schoemaker; Alan Ashworth
The Breakthrough Generations Study: design of a long-term UK cohort study to investigate breast cancer aetiology.
British journal of cancer 2011;105(7):911-7.
2011: Nick Orr; Katarzyna Tomczyk; Alan Ashworth; Peter Broderick; Sarah Chilcott-Burns; Rosie Cooke; Frank Dudbridge; Olivia Fletcher; Richard Houlston; Michael Jones; Anthony Swerdlow
Genetic variants at chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 influence the risk of breast cancer in men.
PLoS genetics 2011;7(9):e1002290.
2011: Paul M Wilkerson; Daniel Wetterskog; Alan Ashworth; Konstantin Dedes; Jessica Frankum; Maryou B K Lambros; christopher Lord; Alan Mackay; Marthe Mansour; Rachael Natrajan; Jorge S Reis-Filho
Functional characterization of EMSY gene amplification in human cancers.
The Journal of pathology 2011;225(1):29-42.
2011: Danielle H Morris; Minouk J Schoemaker; Alan Ashworth; Michael E Jones; Anthony J Swerdlow
Familial concordance for age at natural menopause: results from the Breakthrough Generations Study.
Menopause (New York, N.Y.) 2011;18(9):956-61.
2011: Rachel Sharpe; Jonathan C Welti; Alan Ashworth; Maria T Herrera-Abreu; Damian Johnson; Alan Mackay; Rachael Natrajan; Alex Pearson; Jorge S Reis-Filho; Andrew R Reynolds; Nicholas C Turner
FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(16):5275-86.
2011: Rachel Brough; Maria Antonietta Cerone; Sara Costa-Cabral; Konstantin Dedes; Jessica R Frankum; Maryou B K Lambros; Spiros Linardopoulos; christopher Lord; Alan Mackay; Ana M Mendes-Pereira; Rachael Natrajan; Rumana Rafiq; Teeara Rawjee; Jorge S Reis-Filho; Rachel Sharpe; Kai-Keen Shiu; David Sims; Nicholas C Turner; Daniel Wetterskog; Amar S Ahmad; Ilirjana Bajrami; Alan Ashworth
Functional viability profiles of breast cancer.
Cancer discovery 2011;1(3):260-73.
2011: Sheeba Irshad; Alan Ashworth; Andrew Tutt
Therapeutic potential of PARP inhibitors for metastatic breast cancer.
Expert review of anticancer therapy 2011;11(8):1243-51.
2011: Loukas Moutsianas; Amy Sherborne; Anthony J Swerdlow; Stephen Leslie; Yussanne P Ma; Gil McVean; Alan Ashworth; Peter Broderick; Rosie Cooke; Alexander Dilthey; Victor Enciso-Mora; Richard S Houlston
Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3.
Blood 2011;118(3):670-4.
2011: Danielle H Morris; Minouk J Schoemaker; Alan Ashworth; Michael E Jones; Anthony J Swerdlow
Secular trends in age at menarche in women in the UK born 1908-93: results from the Breakthrough Generations Study.
Paediatric and perinatal epidemiology 2011;25(4):394-400.
2011: Maria Antonietta Cerone; Darren J Burgess; Cristina Naceur-Lombardelli; christopher Lord; Alan Ashworth
High-throughput RNAi screening reveals novel regulators of telomerase.
Cancer research 2011;71(9):3328-40.
2011: Danielle H Morris; Michael E Jones; Minouk J Schoemaker; Alan Ashworth; Anthony J Swerdlow
Familial concordance for age at menarche: analyses from the Breakthrough Generations Study.
Paediatric and perinatal epidemiology 2011;25(3):306-11.
2011: Martin D Forster; Konstantin Dedes; Shahneen Sandhu; Sophia Frentzas; Rebecca Kristeleit; Alan Ashworth; Christopher J Poole; Britta Weigelt; Stan B Kaye; L Rhoda Molife
Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer.
Nature reviews. Clinical oncology 2011;8(5):302-6.
2011: Nicholas C Turner; Alan Ashworth
Biomarkers of PARP inhibitor sensitivity.
Breast cancer research and treatment 2011;127(1):283-6.
2011: Konstantin Dedes; Daniel Wetterskog; Alan Ashworth; Stan B Kaye; Jorge S Reis-Filho
Emerging therapeutic targets in endometrial cancer.
Nature reviews. Clinical oncology 2011;8(5):261-71.
2011: Alan Mackay; Britta Weigelt; Anita Grigoriadis; Bas Kreike; Rachael Natrajan; Roger A'Hern; David S P Tan; Mitch Dowsett; Alan Ashworth; Jorge S Reis-Filho
Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement.
Journal of the National Cancer Institute 2011;103(8):662-73.
2011: Konstantin Dedes; Paul M Wilkerson; Daniel Wetterskog; Britta Weigelt; Alan Ashworth; Jorge S Reis-Filho
Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.
Cell cycle (Georgetown, Tex.) 2011;10(8):1192-9.
2011: Alan Ashworth; Christopher J Lord; Jorge S Reis-Filho
Genetic interactions in cancer progression and treatment.
Cell 2011;145(1):30-8.
2011: Olivia Fletcher; Nichola Johnson; Nick Orr; Fay J Hosking; Lorna J Gibson; Kate Walker; Diana Zelenika; Ivo Gut; Simon Heath; Claire Palles; Ben Coupland; Peter Broderick; Minouk Schoemaker; Michael Jones; Jill Williamson; Sarah Chilcott-Burns; Katarzyna Tomczyk; Gemma Simpson; Kevin B Jacobs; STEPHEN CHANOCK; David J Hunter; Ian P Tomlinson; Anthony Swerdlow; Alan Ashworth; Gillian Ross; Isabel dos Santos Silva; Mark Lathrop; Richard S Houlston; Julian Peto
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
Journal of the National Cancer Institute 2011;103(5):425-35.
2011: Rachel Brough; Jessica R Frankum; Sara Costa-Cabral; christopher Lord; Alan Ashworth
Searching for synthetic lethality in cancer.
Current opinion in genetics & development 2011;21(1):34-41.
2011: David Sims; Marketa Zvelebil; Ana M Mendes-Pereira; Costas Mitsopoulos; Nirupa Murugaesu; Alan Ashworth; Ioannis Assiotis; Darren Burgess; Maria-Antonietta Cerone; Kerry Fenwick; Jessica Frankum; Jarle Hakas; Clare M Isacke; Iwanka Kozarewa; Cristina Lombardelli; christopher Lord
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing.
Genome biology 2011;12(10):R104.
2011: Louise J Barber; Kerry Fenwick; Jarle Hakas; Iwanka Kozarewa; christopher Lord; Costas Mitsopoulos; Juan M Rosa Rosa; David Sims; Marketa Zvelebil; Ioannis Assiotis; Alan Ashworth
Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer.
PloS one 2011;6(7):e21639.
2011: Emilie Rovillain; Alan Ashworth; Christopher J Lord; Louise Mansfield; Parmjit S Jat
An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence.
BMC genomics 2011;12():355.
2010: Monika Graeser; Afshan McCarthy; christopher Lord; Kay Savage; Margaret Hills; Janine Salter; Nicholas Orr; Marina Parton; Ian E Smith; Jorge S Reis-Filho; Mitch Dowsett; Alan Ashworth; Nicholas C Turner
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(24):6159-68.
2010: Farah L Rehman; Christopher J Lord; Alan Ashworth
Synthetic lethal approaches to breast cancer therapy.
Nature reviews. Clinical oncology 2010;7(12):718-24.
2010: D H Morris; M E Jones; Minouk J Schoemaker; Alan Ashworth; Anthony J Swerdlow
Determinants of age at menarche in the UK: analyses from the Breakthrough Generations Study.
British journal of cancer 2010;103(11):1760-4.
2010: Magali Lacroix-Triki; Paula H Suarez; Alan Mackay; Maryou B K Lambros; Rachael Natrajan; Kay Savage; Felipe C Geyer; Britta Weigelt; Alan Ashworth; Jorge S Reis-Filho
Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type.
The Journal of pathology 2010;222(3):282-98.
2010: Konstantin Dedes; Daniel Wetterskog; Ana M Mendes-Pereira; Rachael Natrajan; Maryou B K Lambros; Felipe C Geyer; Radost Vatcheva; Kay Savage; Alan Mackay; christopher Lord; Alan Ashworth; Jorge S Reis-Filho
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Science translational medicine 2010;2(53):53ra75.
2010: Maryou B K Lambros; Rachael Natrajan; Felipe C Geyer; Maria A Lopez-Garcia; Konstantin Dedes; Kay Savage; Magali Lacroix-Triki; Robin L Jones; christopher Lord; Spiros Linardopoulos; Alan Ashworth; Jorge S Reis-Filho
PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(10):1334-45.
2010: J S de Bono; Alan Ashworth
Translating cancer research into targeted therapeutics.
Nature 2010;467(7315):543-9.
2010: Gemma Molyneux; Felipe C Geyer; Fiona-Ann Magnay; Afshan McCarthy; Howard Kendrick; Rachael Natrajan; Alan Mackay; Anita Grigoriadis; Andrew Tutt; Alan Ashworth; Jorge S Reis-Filho; Matthew J Smalley
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.
Cell stem cell 2010;7(3):403-17.
2010: Susana Banerjee; Stan B Kaye; Alan Ashworth
Making the best of PARP inhibitors in ovarian cancer.
Nature reviews. Clinical oncology 2010;7(9):508-19.
2010: Dorine A Bax; Alan Mackay; Suzanne E Little; Diana Carvalho; Marta Viana-Pereira; Narinder Tamber; Anita Grigoriadis; Alan Ashworth; Rui M Reis; David W Ellison; Safa Al-Sarraj; Darren Hargrave; Chris Jones
A distinct spectrum of copy number aberrations in pediatric high-grade gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(13):3368-77.
2010: Alan Ashworth; Rene Bernards
Using functional genetics to understand breast cancer biology.
Cold Spring Harbor perspectives in biology 2010;2(7):a003327.
2010: Felipe C Geyer; Maryou B K Lambros; Rachael Natrajan; Rutika Mehta; Alan Mackay; Kay Savage; Suzanne Parry; Alan Ashworth; Sunil Badve; Jorge S Reis-Filho
Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(7):951-60.
2010: Jeffrey C Francis; Afshan McCarthy; Martin K Thomsen; Alan Ashworth; Amanda Swain
Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.
PLoS genetics 2010;6(6):e1000995.
2010: Kai-Keen Shiu; Rachael Natrajan; Felipe C Geyer; Alan Ashworth; Jorge S Reis-Filho
DNA amplifications in breast cancer: genotypic-phenotypic correlations.
Future oncology (London, England) 2010;6(6):967-84.
2010: Rachael Natrajan; Britta Weigelt; Alan Mackay; Felipe C Geyer; Anita Grigoriadis; David S P Tan; Chris Jones; Christopher J Lord; Radost Vatcheva; Socorro M Rodriguez-Pinilla; José Palacios; Alan Ashworth; Jorge S Reis-Filho
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers.
Breast cancer research and treatment 2010;121(3):575-89.
2010: Peter Fong; Timothy A Yap; David Boss; Craig P Carden; Marja Mergui-Roelvink; Charlie Gourley; Jacques De Greve; Jan Lubinski; Susan Shanley; Christina Messiou; Roger A'Hern; Andrew Tutt; Alan Ashworth; John Stone; James Carmichael; Jan H M Schellens; Johann S de Bono; Stan B Kaye
Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(15):2512-9.
2010: N Turner; Maryou B K Lambros; H M Horlings; A Pearson; R Sharpe; Rachael Natrajan; F C Geyer; M van Kouwenhove; Bas Kreike; Alan Mackay; Alan Ashworth; Marc J van de Vijver; Jorge S Reis-Filho
Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets.
Oncogene 2010;29(14):2013-23.
2010: Tony Sourisseau; Despina Maniotis; Afshan McCarthy; Chan Tang; christopher Lord; Alan Ashworth; Spiros Linardopoulos
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
EMBO molecular medicine 2010;2(4):130-42.
2010: Britta Weigelt; Alan Mackay; Roger A'hern; Rachael Natrajan; David S P Tan; Mitch Dowsett; Alan Ashworth; Jorge S Reis-Filho
Breast cancer molecular profiling with single sample predictors: a retrospective analysis.
The lancet oncology 2010;11(4):339-49.
2010: Madeleine Hewish; Christopher J Lord; Sarah A Martin; David Cunningham; Alan Ashworth
Mismatch repair deficient colorectal cancer in the era of personalized treatment.
Nature reviews. Clinical oncology 2010;7(4):197-208.
2010: Felipe C Geyer; Britta Weigelt; Rachael Natrajan; Maryou B K Lambros; Dario de Biase; Radost Vatcheva; Kay Savage; Alan Mackay; Alan Ashworth; Jorge S Reis-Filho
Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas.
The Journal of pathology 2010;220(5):562-73.
2010: Sarah A Martin; Nuala McCabe; Michelle Mullarkey; Robert Cummins; Darren J Burgess; Yusaku Nakabeppu; Sugako Oka; Elaine Kay; christopher Lord; Alan Ashworth
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.
Cancer cell 2010;17(3):235-48.
2010: Peter Broderick; David Cunningham; Jayaram Vijayakrishnan; Rosie Cooke; Alan Ashworth; Anthony Swerdlow; richard Houlston
IRF4 polymorphism rs872071 and risk of Hodgkin lymphoma.
British journal of haematology 2010;148(3):413-5.
2010: Christopher J Lord; Alan Ashworth
Biology-driven cancer drug development: back to the future.
BMC biology 2010;8():38.
2010: Sarah A Martin; Madeleine Hewish; christopher Lord; Alan Ashworth
Genomic instability and the selection of treatments for cancer.
The Journal of pathology 2010;220(2):281-9.
2010: Peter Tamás; Andrew Macintyre; David Finlay; Rosemary Clarke; Carmen Feijoo-Carnero; Alan Ashworth; Doreen Cantrell
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells.
European journal of immunology 2010;40(1):242-53.
2009: Alan Ashworth
Familial breast cancer: the first linkage.
The lancet oncology 2009;10(12):1212.
2009: Felipe C Geyer; Yael B Kushner; Maryou B K Lambros; Rachael Natrajan; Alan Mackay; Narinder Tamber; Kerry Fenwick; Dave Purnell; Alan Ashworth; Rosemary A Walker; Jorge S Reis-Filho
Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma.
Histopathology 2009;55(6):732-43.
2009: Alan Mackay; Narinder Tamber; Kerry Fenwick; Marjan Iravani; Anita Grigoriadis; Tim Dexter; Christopher J Lord; Jorge S Reis-Filho; Alan Ashworth
A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines.
Breast cancer research and treatment 2009;118(3):481-98.
2009: Afshan McCarthy; christopher Lord; Kay Savage; Anita Grigoriadis; Darrin P Smith; Britta Weigelt; Jorge S Reis-Filho; Alan Ashworth
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.
The Journal of pathology 2009;219(3):306-16.
2009: Elizabeth Jane Iorns; Sanne Martens-de Kemp; Christopher J Lord; Alan Ashworth
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
Carcinogenesis 2009;30(10):1696-701.
2009: Sarah A Martin; Afshan McCarthy; Louise J Barber; Darren J Burgess; Suzanne Parry; christopher Lord; Alan Ashworth
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.
EMBO molecular medicine 2009;1(6-7):323-37.
2009: Ana M Mendes-Pereira; Sarah A Martin; Rachel Brough; Afshan McCarthy; Jessica R Taylor; Jung-Sik Kim; Todd Waldman; christopher Lord; Alan Ashworth
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
EMBO molecular medicine 2009;1(6-7):315-22.
2009: Caterina Marchiò; Maryou B K Lambros; Patrizia Gugliotta; Ludovica Verdun Di Cantogno; Cristina Botta; Barbara Pasini; David S P Tan; Alan Mackay; Kerry Fenwick; Narinder Tamber; Gianni Bussolati; Alan Ashworth; Jorge S Reis-Filho; Anna Sapino
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis.
The Journal of pathology 2009;219(1):16-24.
2009: Antony Oliver; Sally Swift; christopher Lord; Alan Ashworth; Laurence H Pearl
Structural basis for recruitment of BRCA2 by PALB2.
EMBO reports 2009;10(9):990-6.
2009: C Westbury; Jorge S Reis-Filho; Tim Dexter; Betania Mahler-Araujo; Kerry Fenwick; Marjan Iravani; Anita Grigoriadis; Suzanne Parry; David Robertson; Alan Mackay; Alan Ashworth; John R Yarnold; Clare M Isacke
Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation.
The Journal of pathology 2009;219(1):131-40.
2009: Peter Fong; David Boss; Timothy A Yap; Andrew Tutt; Peijun Wu; Marja Mergui-Roelvink; Peter Mortimer; Helen Swaisland; Alan Lau; Mark J O'Connor; Alan Ashworth; James Carmichael; Stan B Kaye; Jan H M Schellens; Johann S de Bono
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
The New England journal of medicine 2009;361(2):123-34.
2009: Maryou B K Lambros; David S P Tan; Robin L Jones; Radost Vatcheva; Kay Savage; N Tamber; Kerry Fenwick; Alan Mackay; Alan Ashworth; Jorge S Reis-Filho
Genomic profile of a secretory breast cancer with an ETV6-NTRK3 duplication.
Journal of clinical pathology 2009;62(7):604-12.
2009: Caterina Marchiò; Marjan Iravani; Rachael Natrajan; Maryou B K Lambros; Felipe C Geyer; Kay Savage; Suzanne Parry; Narinder Tamber; Kerry Fenwick; Alan Mackay; Fernando C Schmitt; Gianni Bussolati; Ian O Ellis; Alan Ashworth; Anna Sapino; Jorge S Reis-Filho
Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components.
The Journal of pathology 2009;218(3):301-15.
2009: christopher Lord; Alan Ashworth
Bringing DNA repair in tumors into focus.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3241-3.
2009: Rachael Natrajan; Maryou B K Lambros; Socorro María Rodríguez-Pinilla; Gema Moreno-Bueno; David S P Tan; Caterina Marchió; Radost Vatcheva; Sydonia Rayter; Betania Mahler-Araujo; Laura G Fulford; Daniela Hungermann; Alan Mackay; Anita Grigoriadis; Kerry Fenwick; Narinder Tamber; David Hardisson; Andrew Tutt; José Palacios; christopher Lord; Horst Buerger; Alan Ashworth; Jorge S Reis-Filho
Tiling path genomic profiling of grade 3 invasive ductal breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2711-22.
2009: David S P Tan; Maryou B K Lambros; Sydonia Rayter; Rachael Natrajan; Radost Vatcheva; Qiong Gao; Caterina Marchiò; Felipe C Geyer; Kay Savage; Suzanne Parry; Kerry Fenwick; Narinder Tamber; Alan Mackay; Tim Dexter; Charles Jameson; W Glenn McCluggage; Alistair R W Williams; Ashley Graham; Dana Faratian; Mona El-Bahrawy; Adam J Paige; Hani Gabra; Martin E Gore; Marketa Zvelebil; Christopher J Lord; Stanley B Kaye; Alan Ashworth; Jorge S Reis-Filho
PPM1D is a potential therapeutic target in ovarian clear cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2269-80.
2009: Rachael Natrajan; Maryou B K Lambros; Felipe C Geyer; Caterina Marchio; David S P Tan; Radost Vatcheva; Kai-Keen Shiu; Daniela Hungermann; Socorro Maria Rodriguez-Pinilla; José Palacios; Alan Ashworth; Horst Buerger; Jorge S Reis-Filho
Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?
Genes, chromosomes & cancer 2009;48(4):351-65.
2009: Nuala McCabe; M A Cerone; T Ohishi; H Seimiya; christopher Lord; Alan Ashworth
Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.
Oncogene 2009;28(11):1465-70.
2009: christopher Lord; Sarah Martin; Alan Ashworth
RNA interference screening demystified.
Journal of clinical pathology 2009;62(3):195-200.
2009: Kara L Britt; Howard Kendrick; Joseph Regan; Gemma Molyneux; Fiona-Ann Magnay; Alan Ashworth; Matthew J Smalley
Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells.
Breast cancer research : BCR 2009;11(2):R20.
2009: Elizabeth Jane Iorns; Christopher J Lord; Anita Grigoriadis; Sarah McDonald; Kerry Fenwick; Alan Mackay; Charles A Mein; Rachael Natrajan; Kay Savage; Narinder Tamber; Jorge S Reis-Filho; Nicholas C Turner; Alan Ashworth
Integrated functional, gene expression and genomic analysis for the identification of cancer targets.
PloS one 2009;4(4):e5120.
2009: Olivia Fletcher; Nichola Johnson; Isabel dos Santos Silva; Outi Kilpivaara; Kristiina Aittomäki; Carl Blomqvist; Heli Nevanlinna; Marijke Wasielewski; Hanne Meijers-Heijerboer; Annegien Broeks; Marjanka K Schmidt; Laura J Van't Veer; Michael Bremer; Thilo Dörk; Elena V Chekmariova; Anna P Sokolenko; Evgeny N Imyanitov; Ute Hamann; M Rashid; Hiltrud Brauch; Christina Justenhoven; Alan Ashworth; Julian Peto
Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(1):230-4.
2009: Elizabeth Jane Iorns; christopher Lord; Alan Ashworth
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization.
The Biochemical journal 2009;417(1):361-70.
2008: Raisa Vuononvirta; Neil J Sebire; Anthony R Dallosso; Jorge S Reis-Filho; Richard D Williams; Alan Mackay; Kerry Fenwick; Anita Grigoriadis; Alan Ashworth; Kathy Pritchard-Jones; Keith W Brown; Gordan M Vujanic; Chris Jones
Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7635-44.
2008: Andrew Tutt; Alan Ashworth
Can genetic testing guide treatment in breast cancer?
European journal of cancer (Oxford, England : 1990) 2008;44(18):2774-80.
2008: christopher Lord; Sarah McDonald; S Swift; Nicholas C Turner; Alan Ashworth
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.
DNA repair 2008;7(12):2010-9.
2008: C Marchiò; Rachael Natrajan; K K Shiu; Maryou B K Lambros; S M Rodriguez-Pinilla; D S P Tan; christopher Lord; D Hungermann; Kerry Fenwick; N Tamber; Alan Mackay; José Palacios; A Sapino; H Buerger; Alan Ashworth; Jorge S Reis-Filho
The genomic profile of HER2-amplified breast cancers: the influence of ER status.
The Journal of pathology 2008;216(4):399-407.
2008: Mhairi C Towler; Sarah Fogarty; Simon A Hawley; David A Pan; David M A Martin; Nick A Morrice; Afshan McCarthy; María N Galardo; Silvina B Meroni; Selva B Cigorraga; Alan Ashworth; Kei Sakamoto; D Grahame Hardie
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
The Biochemical journal 2008;416(1):1-14.
2008: christopher Lord; Alan Ashworth
Targeted therapy for cancer using PARP inhibitors.
Current opinion in pharmacology 2008;8(4):363-9.
2008: Alan Ashworth
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(22):3785-90.
2008: C Marchiò; Marjan Iravani; Rachael Natrajan; M B Lambros; Kay Savage; N Tamber; Kerry Fenwick; Alan Mackay; R Senetta; S Di Palma; F C Schmitt; G Bussolati; L O Ellis; Alan Ashworth; A Sapino; Jorge S Reis-Filho
Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast.
The Journal of pathology 2008;215(4):398-410.
2008: christopher Lord; Elizabeth Jane Iorns; Alan Ashworth
Dissecting resistance to endocrine therapy in breast cancer.
Cell cycle (Georgetown, Tex.) 2008;7(13):1895-8.
2008: Peter T Simpson; Jorge S Reis-Filho; M B K Lambros; C Jones; D Steele; Alan Mackay; M Iravani; K Fenwick; Tim Dexter; A Jones; L Reid; L Da Silva; S J Shin; D Hardisson; Alan Ashworth; Fernando C Schmitt; José Palacios; Sunil R Lakhani
Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas.
The Journal of pathology 2008;215(3):231-44.
2008: Claire Palles; Nichola Johnson; Ben Coupland; Claire Taylor; Jaime Carvajal; Jeff Holly; Ian S Fentiman; Isabel dos Santos Silva; Alan Ashworth; Julian Peto; Olivia Fletcher
Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy.
Human molecular genetics 2008;17(10):1457-64.
2008: Nicholas C Turner; christopher Lord; Elizabeth Jane Iorns; Rachel Brough; S Swift; Richard Elliott; Sydonia Rayter; Andrew Tutt; Alan Ashworth
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
The EMBO journal 2008;27(9):1368-77.
2008: Edurne Arriola; Caterina Marchio; David S P Tan; Suzanne C Drury; Maryou B K Lambros; Rachael Natrajan; Socorro Maria Rodriguez-Pinilla; Alan Mackay; Narinder Tamber; Kerry Fenwick; Chris Jones; Mitch Dowsett; Alan Ashworth; Jorge S Reis-Filho
Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.
Laboratory investigation; a journal of technical methods and pathology 2008;88(5):491-503.
2008: Matthew J Smalley; Jorge S Reis-Filho; Alan Ashworth
BRCA1 and stem cells: tumour typecasting.
Nature cell biology 2008;10(4):377-9.
2008: Olivia Wansbury; Heena Panchal; Michelle James; Suzanne Parry; Alan Ashworth; Beatrice Howard
Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.
The Journal of investigative dermatology 2008;128(4):1009-21.
2008: Olivia Fletcher; Nichola Johnson; Lorna Gibson; Ben Coupland; Agnes Fraser; Angela Leonard; Isabel dos Santos Silva; Alan Ashworth; Richard Houlston; Julian Peto
Association of genetic variants at 8q24 with breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(3):702-5.
2008: Alan Ashworth; Frances Balkwill; Robert C Bast; Jonathan S Berek; Allyson Kaye; Jeffrey A Boyd; Gordon Mills; John N Weinstein; Katie Woolley; Paul Workman
Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007.
Gynecologic oncology 2008;108(3):652-7.
2008: Stacey L Edwards; Rachel Brough; christopher Lord; Rachael Natrajan; Radost Vatcheva; Douglas A Levine; Jeff Boyd; Jorge S Reis-Filho; Alan Ashworth
Resistance to therapy caused by intragenic deletion in BRCA2.
Nature 2008;451(7182):1111-5.
2008: S Rayter; R Elliott; J Travers; Martin G Rowlands; T B Richardson; Kathy Boxall; K Jones; Spiros Linardopoulos; Paul Workman; Wynne Aherne; christopher Lord; Alan Ashworth
A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
Oncogene 2008;27(8):1036-44.
2008: Sarah Martin; christopher Lord; Alan Ashworth
DNA repair deficiency as a therapeutic target in cancer.
Current opinion in genetics & development 2008;18(1):80-6.
2008: Sanne Martens-de Kemp; Nicholas C Turner; Richard Elliott; Nelofer Syed; Ornella Garrone; Milena Gasco; Andrew Tutt; Tim Crook; christopher Lord; Alan Ashworth
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
Cancer cell 2008;13(2):91-104.
2008: Rachel Brough; Debbie Wei; Sophie Leulier; christopher Lord; Yikang S Rong; Alan Ashworth
Functional analysis of Drosophila melanogaster BRCA2 in DNA repair.
DNA repair 2008;7(1):10-9.
2007: Kara Britt; Alan Ashworth; Matthew Smalley
Pregnancy and the risk of breast cancer.
Endocrine-related cancer 2007;14(4):907-33.
2007: Katrin Gudmundsdottir; christopher Lord; Alan Ashworth
The proteasome is involved in determining differential utilization of double-strand break repair pathways.
Oncogene 2007;26(54):7601-6.
2007: Susana Banerjee; Mitch Dowsett; Alan Ashworth; Lesley-Ann Martin
Mechanisms of disease: angiogenesis and the management of breast cancer.
Nature clinical practice. Oncology 2007;4(9):536-50.
2007: Elizabeth Jane Iorns; christopher Lord; Nicholas Turner; Alan Ashworth
Utilizing RNA interference to enhance cancer drug discovery.
Nature reviews. Drug discovery 2007;6(7):556-68.
2007: christopher Lord; Alan Ashworth
RAD51, BRCA2 and DNA repair: a partial resolution.
Nature structural & molecular biology 2007;14(6):461-2.
2007: Michael E Jones; Elizabeth Folkerd; Deborah A Doody; Jhangir Iqbal; Mitch Dowsett; Alan Ashworth; Anthony J Swerdlow
Effect of delays in processing blood samples on measured endogenous plasma sex hormone levels in women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1136-9.
2007: Rachael Natrajan; Richard D Williams; Anita Grigoriadis; Alan Mackay; Kerry Fenwick; Alan Ashworth; Jeffrey S Dome; Paul E Grundy; Kathy Pritchard-Jones; Chris Jones
Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.
Genes, chromosomes & cancer 2007;46(6):607-15.
2007: Nichola Johnson; Olivia Fletcher; Claire Palles; Matthew Rudd; Emily Webb; Gabrielle Sellick; Isabel dos Santos Silva; Valerie McCormack; Lorna Gibson; Agnes Fraser; Angela Leonard; Clare Gilham; Sean V Tavtigian; Alan Ashworth; richard Houlston; Julian Peto
Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Human molecular genetics 2007;16(9):1051-7.
2007: Silvana Di Palma; Maryou B K Lambros; Kay Savage; Chris Jones; Alan Mackay; Tim Dexter; Marjan Iravani; Kerry Fenwick; Alan Ashworth; Jorge S Reis-Filho
Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells.
Journal of clinical pathology 2007;60(5):492-9.
2007: Marc Tischkowitz; Bing Xia; Nelly Sabbaghian; Jorge S Reis-Filho; Nancy Hamel; Guilan Li; erik van beers; Lili Li; Tayma Khalil; Louise A Quenneville; Atilla Omeroglu; Aletta Poll; Pierre Lepage; Nora Wong; petra nederlof; Alan Ashworth; Patricia N Tonin; Steven A Narod; David M Livingston; William D Foulkes
Analysis of PALB2/FANCN-associated breast cancer families.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6788-93.
2007: Nicholas C Turner; Jorge S Reis-Filho; A M Russell; Robert J Springall; Kenneth Ryder; Dawn Steele; Kay Savage; Cheryl E Gillett; Fernando C Schmitt; Alan Ashworth; Andrew Tutt
BRCA1 dysfunction in sporadic basal-like breast cancer.
Oncogene 2007;26(14):2126-32.
2007: Shintaro Takeda; Atsushi Iwai; Mitsuko Nakashima; Daisuke Fujikura; Satoko Chiba; Hong Mei Li; Jun Uehara; Satoshi Kawaguchi; Mitsunori Kaya; Satoshi Nagoya; Takuro Wada; Junying Yuan; Sydonia Rayter; Alan Ashworth; John C Reed; Toshihiko Yamashita; Toshimitsu Uede; Tadaaki Miyazaki
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma.
Anticancer research 2007;27(2):761-8.
2007: A McCarthy; Kay Savage; A Gabriel; C Naceur; Jorge S Reis-Filho; Alan Ashworth
A mouse model of basal-like breast carcinoma with metaplastic elements.
The Journal of pathology 2007;211(4):389-98.
2007: J-Y Pierga; Jorge S Reis-Filho; Susan J Cleator; Tim Dexter; Alan Mackay; P Simpson; Kerry Fenwick; Marjan Iravani; Janine Salter; Margaret Hills; Chris Jones; Alan Ashworth; Ian E Smith; T Powles; Mitch Dowsett
Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
British journal of cancer 2007;96(2):341-51.
2007: Matthew J Smalley; Marjan Iravani; Maria Leao; Anita Grigoriadis; Howard Kendrick; Tim Dexter; Kerry Fenwick; Joseph Regan; Kara Britt; Sarah McDonald; christopher Lord; Alan Mackay; Alan Ashworth
Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.
Breast cancer research : BCR 2007;9(6):R85.
2007: Heena Panchal; Olivia Wansbury; Suzanne Parry; Alan Ashworth; Beatrice Howard
Neuregulin3 alters cell fate in the epidermis and mammary gland.
BMC developmental biology 2007;7():105.
2007: Alan Mackay; Ander Urruticoechea; J Michael Dixon; Tim Dexter; Kerry Fenwick; Alan Ashworth; Suzanne Drury; Alexey Larionov; Oliver Young; Sharon White; William R Miller; Dean B Evans; Mitch Dowsett
Molecular response to aromatase inhibitor treatment in primary breast cancer.
Breast cancer research : BCR 2007;9(3):R37.
2007: Kay Savage; Maryou B K Lambros; David Robertson; Robin L Jones; Chris Jones; Alan Mackay; Michelle James; Jason L Hornick; Emílio M Pereira; Fernanda Milanezi; Christopher D M Fletcher; Fernando C Schmitt; Alan Ashworth; Jorge S Reis-Filho
Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):90-101.
2007: Katherine E Sleeman; Howard Kendrick; David Robertson; Clare M Isacke; Alan Ashworth; Matthew J Smalley
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
The Journal of cell biology 2007;176(1):19-26.
2007: Edurne Arriola; Maryou B K Lambros; Chris Jones; Tim Dexter; Alan Mackay; David S P Tan; Narinder Tamber; Kerry Fenwick; Alan Ashworth; Mitch Dowsett; Jorge S Reis-Filho
Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):75-83.
2007: Rachael Natrajan; Suzanne E Little; N Sodha; Jorge S Reis-Filho; Alan Mackay; Kerry Fenwick; Alan Ashworth; Elizabeth J. Perlman; Jeffrey S Dome; Paul E Grundy; Kathy Pritchard-Jones; Chris Jones
Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour.
The Journal of pathology 2007;211(1):52-9.
2006: Jorge S Reis-Filho; Peter T Simpson; Nicholas C Turner; Maryou B K Lambros; Chris Jones; Alan Mackay; Anita Grigoriadis; David Sarrio; Kay Savage; Tim Dexter; Marjan Iravani; Kerry Fenwick; Barbara Weber; David Hardisson; Fernando C Schmitt; José Palacios; Sunil R Lakhani; Alan Ashworth
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6652-62.
2006: Katrin Gudmundsdottir; Alan Ashworth
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.
Oncogene 2006;25(43):5864-74.
2006: Rachael Natrajan; Richard D Williams; Sandra Hing; Alan Mackay; Jorge S Reis-Filho; Kerry Fenwick; Marjan Iravani; Haukur Valgeirsson; Anita Grigoriadis; Cordelia F Langford; Oliver M Dovey; Simon G Gregory; B L Weber; Alan Ashworth; Paul E Grundy; Kathy Pritchard-Jones; Chris Jones
Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse.
The Journal of pathology 2006;210(1):49-58.
2006: Beatrice Howard; Alan Ashworth
Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.
PLoS genetics 2006;2(8):e112.
2006: Nuala McCabe; Nicholas C Turner; christopher Lord; Katarzyna Kluzek; Aneta Bialkowska; Sally Swift; Sabrina Giavara; Mark J O'Connor; Andrew Tutt; Malgorzata Z Zdzienicka; Graeme C M Smith; Alan Ashworth
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
Cancer research 2006;66(16):8109-15.
2006: christopher Lord; Michelle D Garrett; Alan Ashworth
Targeting the double-strand DNA break repair pathway as a therapeutic strategy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4463-8.
2006: Jorge S Reis-Filho; Céline Pinheiro; Maryou B K Lambros; Fernanda Milanezi; Silvia Carvalho; Kay Savage; Peter T Simpson; Chris Jones; S Swift; Alan Mackay; Rui M Reis; J L Hornick; Emílio M Pereira; Fátima Baltazar; Christopher D M Fletcher; Alan Ashworth; Sunil R Lakhani; Fernando C Schmitt
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.
The Journal of pathology 2006;209(4):445-53.
2006: Olivia Fletcher; Nichola Johnson; Claire Palles; Isabel dos Santos Silva; Valerie McCormack; John Whittaker; Alan Ashworth; Julian Peto
Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk.
Journal of the National Cancer Institute 2006;98(14):1014-8.
2006: S Banerjee; Jorge S Reis-Filho; S Ashley; D Steele; Alan Ashworth; S R Lakhani; I E Smith
Basal-like breast carcinomas: clinical outcome and response to chemotherapy.
Journal of clinical pathology 2006;59(7):729-35.
2006: Sharon W Horsley; Alan Mackay; Marjan Iravani; Kerry Fenwick; Haukur Valgeirsson; Tim Dexter; Alan Ashworth; Lyndal Kearney
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes, chromosomes & cancer 2006;45(6):554-64.
2006: Kei Sakamoto; Elham Zarrinpashneh; Grant R Budas; Anne-Catherine Pouleur; Anindya Dutta; Alan R Prescott; Jean-Louis J Vanoverschelde; Alan Ashworth; Aleksandar Jovanović; Dario R Alessi; Luc Bertrand
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E780-8.
2006: Maryou B K Lambros; Peter T Simpson; Chris Jones; Rachael Natrajan; Charlotte Westbury; Dawn Steele; Kay Savage; Alan Mackay; Fernando C Schmitt; Alan Ashworth; Jorge S Reis-Filho
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Laboratory investigation; a journal of technical methods and pathology 2006;86(4):398-408.
2006: Frances R Balkwill; Alan Ashworth; Robert C Bast; Jonathon S Berek; Jeff Boyd; Mary L Disis; Hani Gabra; Martin E Gore; Thomas C Hamilton; Ian J Jacobs; Stan B Kaye; Elise C Kohn; Gordon B Mills; Nicole D Urban
10th Biennial Helene Harris Memorial Trust meeting.
Cancer research 2006;66(6):2904-6.
2006: Benjamin J Friedmann; Martyn E Caplin; Boris Savic; Tahir Shah; christopher Lord; Alan Ashworth; John A Hartley; Daniel Hochhauser
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Molecular cancer therapeutics 2006;5(2):209-18.
2006: Jorge S Reis-Filho; Dawn Steele; Silvana Di Palma; Robin L Jones; Kay Savage; Michelle James; Fernanda Milanezi; Fernando C Schmitt; Alan Ashworth
Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(2):307-19.
2006: Susan J Cleator; Anna Tsimelzon; Alan Ashworth; Mitch Dowsett; Timothy Dexter; Trevor Powles; Susan G Hilsenbeck; Helen Wong; C Kent Osborne; Peter O'Connell; Jenny C Chang
Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (cytoxan) (AC) response and resistance.
Breast cancer research and treatment 2006;95(3):229-33.
2006: Carmen Arias-Lopez; Iciar Lazaro-Trueba; Peter Kerr; christopher Lord; Tim Dexter; Marjan Iravani; Alan Ashworth; Augusto Silva
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
EMBO reports 2006;7(2):219-24.
2006: Suzanne E Little; Raisa Vuononvirta; Jorge S Reis-Filho; Rachael Natrajan; Marjan Iravani; Kerry Fenwick; Alan Mackay; Alan Ashworth; Kathy Pritchard-Jones; Chris Jones
Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA.
Genomics 2006;87(2):298-306.
2006: Anita Grigoriadis; Alan Mackay; Jorge S Reis-Filho; Dawn Steele; Christian Iseli; Brian J Stevenson; Victor Jongeneel; Haukur Valgeirsson; Kerry Fenwick; Marjan Iravani; Maria Leao; Andrew J G Simpson; Robert L Strausberg; Parmjit S Jat; Alan Ashworth; A Munro Neville; Michael J O'Hare
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.
Breast cancer research : BCR 2006;8(5):R56.
2006: Susan J Cleator; Trevor J Powles; Tim Dexter; Laura G Fulford; Alan Mackay; Ian E Smith; Haukur Valgeirsson; Alan Ashworth; Mitch Dowsett
The effect of the stromal component of breast tumours on prediction of clinical outcome using gene expression microarray analysis.
Breast cancer research : BCR 2006;8(3):R32.
2006: Katherine E Sleeman; Howard Kendrick; Alan Ashworth; Clare M Isacke; Matthew J Smalley
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells.
Breast cancer research : BCR 2006;8(1):R7.
2005: Nichola Johnson; Olivia Fletcher; Cristina Naceur-Lombardelli; Isabel dos Santos Silva; Alan Ashworth; Julian Peto
Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study.
Lancet 2005;366(9496):1554-7.
2005: Heidi M Sowter; Alan Ashworth
BRCA1 and BRCA2 as ovarian cancer susceptibility genes.
Carcinogenesis 2005;26(10):1651-6.
2005: Nuala McCabe; christopher Lord; Andrew Tutt; Niall M B Martin; Graeme C M Smith; Alan Ashworth
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
Cancer biology & therapy 2005;4(9):934-6.
2005: Beatrice Howard; Heena Panchal; Afshan McCarthy; Alan Ashworth
Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
Genes & development 2005;19(17):2078-90.
2005: Jorge S Reis-Filho; Peter T Simpson; Chris Jones; Dawn Steele; Alan Mackay; Marjan Iravani; Kerry Fenwick; Haukur Valgeirsson; Maryou B K Lambros; Alan Ashworth; José Palacios; Fernando Schmitt; Sunil R Lakhani
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity.
The Journal of pathology 2005;207(1):1-13.
2005: Alan Ashworth
Oh what a tangled web it weaves: BRCA1 and DNA decatenation.
Cancer cell 2005;8(2):95-7.
2005: Nicholas Turner; Andrew Tutt; Alan Ashworth
Targeting the DNA repair defect of BRCA tumours.
Current opinion in pharmacology 2005;5(4):388-93.
2005: Kei Sakamoto; Afshan McCarthy; Darrin Smith; Kevin A Green; D Grahame Hardie; Alan Ashworth; Dario R Alessi
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.
The EMBO journal 2005;24(10):1810-20.
2005: Hannah Farmer; Nuala McCabe; christopher Lord; Andrew Tutt; Damian A Johnson; Tobias B Richardson; Manuela Santarosa; Krystyna J Dillon; Ian Hickson; Charlotte Knights; Niall M B Martin; Stephen P Jackson; Graeme C M Smith; Alan Ashworth
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Nature 2005;434(7035):917-21.
2005: Paraic Kenny; Tariq Enver; Alan Ashworth
Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells.
BMC cancer 2005;5():3.
2005: Andrew Tutt; christopher Lord; Nuala McCabe; H Farmer; Nicholas Turner; Niall M B Martin; Stephen P Jackson; G C M Smith; Alan Ashworth
Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer.
Cold Spring Harbor symposia on quantitative biology 2005;70():139-48.
2005: Matthew J Smalley; I Titley; Alan Ashworth
An improved definition of mouse mammary epithelial side population cells.
Cytotherapy 2005;7(6):497-508.
2005: Nicola Brookman-Amissah; C Duchesnes; M P Williamson; Q Wang; A Ahmed; Mark R Feneley; Alan Mackay; Alex Freeman; Kerry Fenwick; Marjan Iravani; B Weber; Alan Ashworth; John R Masters
Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH.
Prostate cancer and prostatic diseases 2005;8(4):335-43.
2005: Olivia Fletcher; Lorna Gibson; Nichola Johnson; Dan R Altmann; Jeff M P Holly; Alan Ashworth; Julian Peto; Isabel Dos Santos Silva
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):2-19.
2004: Nazneen Rahman; Alan Ashworth
A new gene on the X involved in Fanconi anemia.
Nature genetics 2004;36(11):1142-3.
2004: Nicholas Turner; Andrew Tutt; Alan Ashworth
Hallmarks of 'BRCAness' in sporadic cancers.
Nature reviews. Cancer 2004;4(10):814-9.
2004: Alan Ashworth
Refocusing on BRCA1.
Nature cell biology 2004;6(10):916-7.
2004: Katrin Gudmundsdottir; christopher Lord; Emily Witt; Andrew Tutt; Alan Ashworth
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.
EMBO reports 2004;5(10):989-93.
2004: Katrin Gudmundsdottir; Alan Ashworth
BRCA2 in meiosis: turning over a new leaf.
Trends in cell biology 2004;14(8):401-4.
2004: Shobbir Hussain; James B Wilson; Annette L Medhurst; James Hejna; Emily Witt; Sahana Ananth; Adelina Davies; Jean-Yves Masson; Robb Moses; Stephen C West; Johan P de Winter; Alan Ashworth; Nigel Jones; Christopher G Mathew
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
Human molecular genetics 2004;13(12):1241-8.
2004: Manuela Santarosa; Alan Ashworth
Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.
Biochimica et biophysica acta 2004;1654(2):105-22.
2004: James Spicer; Alan Ashworth
LKB1 kinase: master and commander of metabolism and polarity.
Current biology : CB 2004;14(10):R383-5.
2004: S Cleator; Alan Ashworth
Molecular profiling of breast cancer: clinical implications.
British journal of cancer 2004;90(6):1120-4.
2003: Matthew J Smalley; Alan Ashworth
Stem cells and breast cancer: A field in transit.
Nature reviews. Cancer 2003;3(11):832-44.
2003: Madhuri Warren; christopher Lord; Julio Masabanda; Darren Griffin; Alan Ashworth
Phenotypic effects of heterozygosity for a BRCA2 mutation.
Human molecular genetics 2003;12(20):2645-56.
2003: Andrew Tutt; Alan Ashworth
Close relatives or distant cousins?
The lancet oncology 2003;4(10):593-4.
2003: Shobbir Hussain; Emily Witt; Pia A J Huber; Annette L Medhurst; Alan Ashworth; Christopher G Mathew
Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1.
Human molecular genetics 2003;12(19):2503-10.
2003: Eirini Trompouki; Eudoxia G Hatzivassiliou; Theodore Tsichritzis; Hannah Farmer; Alan Ashworth; George Mosialos
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
Nature 2003;424(6950):793-6.
2003: Mitch Dowsett; Alan Ashworth
New biology of the oestrogen receptor.
Lancet 2003;362(9380):260-2.
2003: James Spicer; Sydonia Rayter; Neville Young; Richard Elliott; Alan Ashworth; Darrin Smith
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
Oncogene 2003;22(30):4752-6.
2003: Lucy East; Afshan McCarthy; Dirk Wienke; Justin Sturge; Alan Ashworth; Clare M Isacke
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.
EMBO reports 2003;4(7):710-6.
2003: Nicolas Foray; Didier Marot; Anastasia Gabriel; Voahangy Randrianarison; Antony M Carr; Michel Perricaudet; Alan Ashworth; Penny A Jeggo
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
The EMBO journal 2003;22(11):2860-71.
2003: Andrew Tutt; Frances Connor; David Bertwistle; Peter Kerr; John Peacock; Gill Ross; Alan Ashworth
Cell cycle and genetic background dependence of the effect of loss of BRCA2 on ionizing radiation sensitivity.
Oncogene 2003;22(19):2926-31.
2003: Caroline Stone; Nuala McCabe; Alan Ashworth
X-chromosome inactivation: X marks the spot for BRCA1.
Current biology : CB 2003;13(2):R63-4.
2003: Azra J Alvi; Helen Clayton; Chirag Joshi; Tariq Enver; Alan Ashworth; Maria d M Vivanco; Trevor C Dale; Matthew J Smalley
Functional and molecular characterisation of mammary side population cells.
Breast cancer research : BCR 2003;5(1):R1-8.
2002: Hilmar Vidarsson; Evgenia K Mikaelsdottir; Thorunn Rafnar; D Bertwistle; Alan Ashworth; Jorunn E Eyfjord; S Valgeirsdottir
BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity.
FEBS letters 2002;532(1-2):247-52.
2002: Andrew Tutt; Alan Ashworth
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.
Trends in molecular medicine 2002;8(12):571-6.
2002: Paraic Kenny; Tariq Enver; Alan Ashworth
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line.
BMC molecular biology 2002;3():13.
2002: Emily Witt; Alan Ashworth
Biomedicine. D-Day for BRCA2.
Science (New York, N.Y.) 2002;297(5581):534.
2002: Aspasia Theodosiou; Alan Ashworth
MAP kinase phosphatases.
Genome biology 2002;3(7):REVIEWS3009.
2002: Aspasia Theodosiou; Alan Ashworth
Differential effects of stress stimuli on a JNK-inactivating phosphatase.
Oncogene 2002;21(15):2387-97.
2002: Madhuri Warren; Amanda Smith; Natalie Partridge; Julio Masabanda; Darren Griffin; Alan Ashworth
Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations.
Human molecular genetics 2002;11(7):841-51.
2002: Andrew Tutt; Conny Th M van Oostrom; Gillian M Ross; Harry van Steeg; Alan Ashworth
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.
EMBO reports 2002;3(3):255-60.
2001: D P Smith; Sydonia Rayter; C Niederlander; J Spicer; C M Jones; Alan Ashworth
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
Human molecular genetics 2001;10(25):2869-77.
2001: S R Lakhani; Alan Ashworth
Microarray and histopathological analysis of tumours: the future and the past?
Nature reviews. Cancer 2001;1(2):151-7.
2001: J Perry; S Palmer; A Gabriel; Alan Ashworth
A short pseudoautosomal region in laboratory mice.
Genome research 2001;11(11):1826-32.
2001: Andrew Tutt; David Bertwistle; J Valentine; A Gabriel; S Swift; Gill Ross; C Griffin; J Thacker; Alan Ashworth
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.
The EMBO journal 2001;20(17):4704-16.
2001: P Kerr; Alan Ashworth
New complexities for BRCA1 and BRCA2.
Current biology : CB 2001;11(16):R668-76.
2001: S R Lakhani; M J O'Hare; Alan Ashworth
Profiling familial breast cancer.
Nature medicine 2001;7(4):408-10.
2000: David Bertwistle; Alan Ashworth
BRCA1 and BRCA2.
Current biology : CB 2000;10(16):R582.
2000: J T Romer; Alan Ashworth
The upstream region of the mouse xist gene contains two ribosomal protein pseudogenes.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(6):461-3.
2000: S de Martino; Yi-Lin Yan; T Jowett; John H Postlethwait; Z M Varga; Alan Ashworth; Caroline A Austin
Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;217(3):279-92.
2000: H Sheikh; Helen Yarwood; Alan Ashworth; Clare M Isacke
Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor.
Journal of cell science 2000;113 ( Pt 6)():1021-32.
1999: J Perry; Short Kieran; J T Romer; S Swift; Timothy C Cox; Alan Ashworth
FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules.
Genomics 1999;62(3):385-94.
1999: A Theodosiou; A Smith; Corine Gillieron; Steve Arkinstall; Alan Ashworth
MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.
Oncogene 1999;18(50):6981-8.
1999: A Smith; A Smith; Saif Alrubaie; C Coehlo; Sally J Leevers; Alan Ashworth
Alternative splicing of the Drosophila PTEN gene.
Biochimica et biophysica acta 1999;1447(2-3):313-7.
1999: Andrew Tutt; A Gabriel; David Bertwistle; Frances Connor; H Paterson; J Peacock; Gill Ross; Alan Ashworth
Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.
Current biology : CB 1999;9(19):1107-10.
1999: J Perry; Alan Ashworth
Evolutionary rate of a gene affected by chromosomal position.
Current biology : CB 1999;9(17):987-9.
1999: D P Smith; J Spicer; A Smith; S Swift; Alan Ashworth
The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase.
Human molecular genetics 1999;8(8):1479-85.
1999: N J Marston; W J Richards; D Hughes; David Bertwistle; Christopher J Marshall; Alan Ashworth
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
Molecular and cellular biology 1999;19(7):4633-42.
1999: Walter Low; A Smith; Alan Ashworth; Mary Collins
JNK activation is not required for Fas-mediated apoptosis.
Oncogene 1999;18(25):3737-41.
1999: S P De Martino; Fiona Errington; Alan Ashworth; T Jowett; Caroline A Austin
sox30: a novel zebrafish sox gene expressed in a restricted manner at the midbrain-hindbrain boundary during neurogenesis.
Development genes and evolution 1999;209(6):357-62.
1999: D Bertwistle; Alan Ashworth
The pathology of familial breast cancer: How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?
Breast cancer research : BCR 1999;1(1):41-7.
1998: O Korobova; Priscilla W Lane; J Perry; S Palmer; Alan Ashworth; Muriel T Davisson; Norman Arnheim
Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.
Genomics 1998;54(3):556-9.
1998: S Swift; C Blackburn; Grant Morahan; Alan Ashworth
Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse.
Biochimica et biophysica acta 1998;1442(2-3):394-8.
1998: M Muda; A Theodosiou; Corine Gillieron; A Smith; Christian Chabert; Montserrat Camps; U Boschert; N Rodrigues; K Davies; Alan Ashworth; Steve Arkinstall
The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity.
The Journal of biological chemistry 1998;273(15):9323-9.
1998: S Roth; Paula Kristo; Annika Auranen; M Shayehgi; Sheila Seal; N Collins; Rita Barfoot; Nazneen Rahman; Pekka Klemi; Seija Grénman; Laura Sarantaus; Heli Nevanlinna; Ralf Butzow; Alan Ashworth; Michael R Stratton; Lauri A Aaltonen
A missense mutation in the BRCA2 gene in three siblings with ovarian cancer.
British journal of cancer 1998;77(8):1199-202.
1998: A Smith; Alan Ashworth
Cancer predisposition: where's the phosphate?
Current biology : CB 1998;8(7):R241-3.
1998: David Bertwistle; Alan Ashworth
Functions of the BRCA1 and BRCA2 genes.
Current opinion in genetics & development 1998;8(1):14-20.
1998: J Perry; S Feather; A Smith; S Palmer; Alan Ashworth
The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome.
Human molecular genetics 1998;7(2):299-305.
1998: Paul S Burgoyne; Shantha K Mahadevaiah; J Perry; S J Palmer; Alan Ashworth
The Y* rearrangement in mice: new insights into a perplexing PAR.
Cytogenetics and cell genetics 1998;80(1-4):37-40.
1997: David Bertwistle; S Swift; N J Marston; L E Jackson; S Crossland; MR Crompton; Christopher J Marshall; Alan Ashworth
Nuclear location and cell cycle regulation of the BRCA2 protein.
Cancer research 1997;57(24):5485-8.
1997: Frances Connor; David Bertwistle; PJ Mee; G M Ross; S Swift; E Grigorieva; Victor L J Tybulewicz; Alan Ashworth
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation.
Nature genetics 1997;17(4):423-30.
1997: A Smith; Francisco Ramos-Morales; Alan Ashworth; M Collins
A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells.
Current biology : CB 1997;7(11):893-6.
1997: S Palmer; J Perry; D Kipling; Alan Ashworth
A gene spans the pseudoautosomal boundary in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12030-5.
1997: Dario R Alessi; Maria Deak; Antonio Casamayor; F B Caudwell; Nick Morrice; David G Norman; P Gaffney; CB Reese; CN MacDougall; D Harbison; Alan Ashworth; Mary Bownes
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Current biology : CB 1997;7(10):776-89.
1997: A Smith; C Price; M Cullen; M Muda; A King; B Ozanne; Steve Arkinstall; Alan Ashworth
Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).
Genomics 1997;42(3):524-7.
1997: L B Herzing; J T Romer; J M Horn; Alan Ashworth
Xist has properties of the X-chromosome inactivation centre.
Nature 1997;386(6622):272-5.
1997: M Muda; U Boschert; A Smith; Bruno Antonsson; Corine Gillieron; Christian Chabert; Montserrat Camps; Isabelle Martinou; Alan Ashworth; Steve Arkinstall
Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4.
The Journal of biological chemistry 1997;272(8):5141-51.
1997: Frances Connor; A Smith; R Wooster; M Stratton; A Dixon; E Campbell; T M Tait; T Freeman; Alan Ashworth
Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.
Human molecular genetics 1997;6(2):291-300.
1997: Graham R Bignell; G Micklem; Michael R Stratton; Alan Ashworth; Richard Wooster
The BRC repeats are conserved in mammalian BRCA2 proteins.
Human molecular genetics 1997;6(1):53-8.
1996: M Muda; A Theodosiou; N Rodrigues; U Boschert; Montserrat Camps; Corine Gillieron; K Davies; Alan Ashworth; Steve Arkinstall
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases.
The Journal of biological chemistry 1996;271(44):27205-8.
1996: V M Wunderle; Ricky Critcher; Alan Ashworth; PN Goodfellow
Cloning and characterization of SOX5, a new member of the human SOX gene family.
Genomics 1996;36(2):354-8.
1996: Jose Antonio Garcia-Marco; Carlos Caldas; C M Price; LM Wiedemann; Alan Ashworth; Daniel Catovsky
Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia.
Blood 1996;88(5):1568-75.
1996: M A Bogoyevitch; J Gillespie-Brown; A J Ketterman; Stephen J Fuller; R Ben-Levy; Alan Ashworth; C J Marshall; Peter H Sugden
Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion.
Circulation research 1996;79(2):162-73.
1996: Pei-Wen Chiang; Patricia Baldacci; Charles Babinet; Sally A Camper; DE Watkins-Chow; D D Baker; C H Tsai; S Ramamoorthy; E King; A C Slack; E Fogel; Grant Morahan; Alan Ashworth; C C Blackburn; David M Kurnit
Linkage mapping of murine homolog of the yeast SPT6 gene to MMU11B1.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(6):459-60.
1996: Johnathan M Lancaster; Richard Wooster; J Mangion; CM Phelan; C Cochran; Curtis Gumbs; Sheila Seal; Rita Barfoot; N Collins; Graham R Bignell; S Patel; Rifat A Hamoudi; Catharina Larsson; Roger W Wiseman; Andrew Berchuck; J Dirk Iglehart; Jeffrey R Marks; Alan Ashworth; Michael R Stratton; P Andrew Futreal
BRCA2 mutations in primary breast and ovarian cancers.
Nature genetics 1996;13(2):238-40.
1996: A M Theodosiou; NR Rodrigues; M A Nesbit; H J Ambrose; H Paterson; E McLellan-Arnold; Y Boyd; M A Leversha; N Owen; Derek J Blake; Alan Ashworth; Kay E Davies
A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region.
Human molecular genetics 1996;5(5):675-84.
1996: Edith Heard; C Kress; F Mongelard; B Courtier; Claire Rougeulle; Alan Ashworth; Claire VOURC'H; Charles Babinet; Philip Avner
Transgenic mice carrying an Xist-containing YAC.
Human molecular genetics 1996;5(4):441-50.
1996: D Kipling; H E Wilson; E J Thomson; M Lee; J Perry; S Palmer; Alan Ashworth; Howard J Cooke
Structural variation of the pseudoautosomal region between and within inbred mouse strains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):171-5.
1995: A G King; B W Ozanne; C Smythe; Alan Ashworth
Isolation and characterisation of a uniquely regulated threonine, tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk.
Oncogene 1995;11(12):2553-63.
1995: L B Herzing; Alan Ashworth
Construction of specific cosmids from YACs by homologous recombination in yeast.
Nucleic acids research 1995;23(19):4005-6.
1995: V M Macaulay; P J Bates; M J McLean; Martin G Rowlands; TC Jenkins; Alan Ashworth; Stephen Neidle
Inhibition of aromatase expression by a psoralen-linked triplex-forming oligonucleotide targeted to a coding sequence.
FEBS letters 1995;372(2-3):222-8.
1995: Frances Connor; E Wright; Paul Denny; P Koopman; Alan Ashworth
The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse.
Nucleic acids research 1995;23(17):3365-72.
1995: Paul Denny; Alan Ashworth
Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(9):683.
1995: Michael F Olson; Alan Ashworth; Alan Hall
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1.
Science (New York, N.Y.) 1995;269(5228):1270-2.
1995: S Swift; Alan Ashworth
The mouse Ftzf1 gene required for gonadal and adrenal development maps to mouse chromosome 2.
Genomics 1995;28(3):609-10.
1995: S Palmer; J Perry; Alan Ashworth
A contravention of Ohno's law in mice.
Nature genetics 1995;10(4):472-6.
1995: K Lee; V M Macaulay; J E Nicholls; Simone Detre; Alan Ashworth; Mitch Dowsett
An in vivo model of intratumoural aromatase using aromatase-transfected MCF7 human breast cancer cells.
International journal of cancer. Journal international du cancer 1995;62(3):297-302.
1995: J M Horn; Alan Ashworth
A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes.
Human molecular genetics 1995;4(6):1041-7.
1995: P Taylor-Harris; S Swift; Alan Ashworth
Zfyl encodes a nuclear sequence-specific DNA binding protein.
FEBS letters 1995;360(3):315-9.
1995: Dario R Alessi; Philip Cohen; Alan Ashworth; S Cowley; S J Leevers; C J Marshall
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Methods in enzymology 1995;255():279-90.
1994: Paul Denny; Alan Ashworth
Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(10):643-5.
1994: Frances Connor; P D Cary; Christopher M Read; N S Preston; Paul C Driscoll; Paul Denny; Colyn Crane-Robinson; Alan Ashworth
DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5.
Nucleic acids research 1994;22(16):3339-46.
1994: Alan Ashworth; A N Malik; N A Walkley; H Kubota; K R Willison
The Tcp-1-related gene, Cctg, maps to mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(8):509-10.
1994: Dario R Alessi; Y Saito; D G Campbell; Philip Cohen; G Sithanandam; U Rapp; Alan Ashworth; C J Marshall; S Cowley
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
The EMBO journal 1994;13(7):1610-9.
1994: Y Saito; N Gomez; D G Campbell; Alan Ashworth; C J Marshall; Philip Cohen
The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells.
FEBS letters 1994;341(1):119-24.
1994: H Kubota; G Hynes; A Carne; Alan Ashworth; Keith R Willison
Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin.
Current biology : CB 1994;4(2):89-99.
1994: V M Macaulay; J E Nicholls; J Gledhill; Martin G Rowlands; Mitch Dowsett; Alan Ashworth
Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.
British journal of cancer 1994;69(1):77-83.
1993: Alan Ashworth
Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes.
Genomics 1993;18(2):195-8.
1993: D A Hughes; Alan Ashworth; C J Marshall
Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.
Nature 1993;364(6435):349-52.
1993: F K Bedford; Alan Ashworth; Tariq Enver; LM Wiedemann
HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.
Nucleic acids research 1993;21(5):1245-9.
1993: Mitch Dowsett; V Macaulay; J Gledhill; C Ryde; J Nicholls; Alan Ashworth; J A McKinna; Ian E Smith
Control of aromatase in breast cancer cells and its importance for tumor growth.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):605-9.
1993: G F Kay; G D Penny; D Patel; Alan Ashworth; Neil Brockdorff; S Rastan
Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation.
Cell 1993;72(2):171-82.
1993: A S Goldsborough; L E Healy; N G Copeland; D J Gilbert; N A Jenkins; Keith R Willison; Alan Ashworth
Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11.
Nucleic acids research 1993;21(1):127-34.
1992: Alan Ashworth; S Nakielny; Philip Cohen; C Marshall
The amino acid sequence of a mammalian MAP kinase kinase.
Oncogene 1992;7(12):2555-6.
1992: Frances Connor; Alan Ashworth
Sequence of cDNA for Xenopus XZFY-1.
Nucleic acids research 1992;20(21):5845.
1992: Neil Brockdorff; Alan Ashworth; G F Kay; V M McCabe; D P Norris; P J Cooper; S Swift; S Rastan
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.
Cell 1992;71(3):515-26.
1992: H Kubota; K Willison; Alan Ashworth; Masami Nozaki; H Miyamoto; H Yamamoto; A Matsushiro; T Morita
Structure and expression of the gene encoding mouse t-complex polypeptide (Tcp-1).
Gene 1992;120(2):207-15.
1992: Paul Denny; S Swift; Frances Connor; Alan Ashworth
An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.
The EMBO journal 1992;11(10):3705-12.
1992: Paul Denny; S Swift; Nigel J Brand; N Dabhade; P Barton; Alan Ashworth
A conserved family of genes related to the testis determining gene, SRY.
Nucleic acids research 1992;20(11):2887.
1991: G F Kay; Alan Ashworth; G D Penny; M Dunlop; S Swift; Neil Brockdorff; S Rastan
A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1.
Nature 1991;354(6353):486-9.
1991: Paul Denny; Alan Ashworth
A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis.
Gene 1991;106(2):221-7.
1991: Alan Ashworth; S Rastan; Robin Lovell-Badge; G Kay
X-chromosome inactivation may explain the difference in viability of XO humans and mice.
Nature 1991;351(6325):406-8.
1991: Neil Brockdorff; Alan Ashworth; G F Kay; P Cooper; S Smith; V M McCabe; D P Norris; G D Penny; D Patel; S Rastan
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.
Nature 1991;351(6324):329-31.
1991: P Koopman; Alan Ashworth; Robin Lovell-Badge
The ZFY gene family in humans and mice.
Trends in genetics : TIG 1991;7(4):132-6.
1991: Alan Ashworth; Paul Denny
Zinc finger protein genes in the mouse genome.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(3):196-200.
1990: Alan Ashworth; A Kraft
Cloning of a potentially soluble receptor for human GM-CSF.
Nucleic acids research 1990;18(23):7178.
1990: Alan Ashworth; B Skene; S Swift; Robin Lovell-Badge
Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.
The EMBO journal 1990;9(5):1529-34.
1990: A Goldsborough; Alan Ashworth; Keith R Willison
Cloning and sequencing of POU-boxes expressed in mouse testis.
Nucleic acids research 1990;18(6):1634.
1989: Elizabeth A Shephard; Ian R Phillips; I Santisteban; L F West; C N Palmer; Alan Ashworth; Sue Povey
Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2.
Annals of human genetics 1989;53(Pt 4):291-301.
1989: Alan Ashworth; S Swift; N Affara
Sequence of cDNA for murine Zfy-1, a candidate for Tdy.
Nucleic acids research 1989;17(7):2864.
1989: Alan Ashworth; B P Williams; Arthur Buchberg; P N Goodfellow; E Solomon; J Potter; K R Willison
Chromosomal localization of zinc finger protein genes in man and mouse.
Genomics 1989;4(3):323-7.
1987: Elizabeth A Shephard; Ian R Phillips; Alan Ashworth; Jane E Ferrie; L A Forrest; D R Bell; S Thompson; C A Austin
Structure and expression of genes coding for components of the cytochrome P-450-mediated mono-oxygenase.
Biochemical Society transactions 1987;15(4):573-5.
1986: Alan Ashworth; E A Shephard; I R Phillips
Disease-gene relationship seen.
Nature 1986;322(6080):599.
1985: I R Phillips; E A Shephard; Alan Ashworth; B R Rabin
Isolation and sequence of a human cytochrome P-450 cDNA clone.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(4):983-7.
1984: I R Phillips; E A Shephard; Alan Ashworth
Cloning of cDNA coding for a rat liver protein whose expression is subject to gender-specific regulation by xenobiotics.
Biochemical Society transactions 1984;12(1):103-4.
1983: Ian R Phillips; Elizabeth A Shephard; Alan Ashworth; B R Rabin
Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics.
Gene 1983;26(1):41-52.
1983: Ian R Phillips; Elizabeth A Shephard; B R Rabin; R M Bayney; S F Pike; Alan Ashworth; M R Estall
Factors controlling the expression of genes coding for drug-metabolizing enzymes.
Biochemical Society transactions 1983;11(4):460-3.
1982: Elizabeth A Shephard; Ian R Phillips; S F Pike; Alan Ashworth; B R Rabin
Differential effect of phenobarbital and beta-naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase.
FEBS letters 1982;150(2):375-80.