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Alan Ashworth

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Mackay Alan; Tamber Narinder; Fenwick Kerry; Iravani Marjan; Grigoriadis Anita; Dexter Tim; Lord Christopher J; Reis-Filho Jorge S; Ashworth Alan
A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines.
McCarthy Afshan; Lord Christopher J; Savage Kay; Grigoriadis Anita; Smith Darrin P; Weigelt Britta; Reis-Filho Jorge S; Ashworth Alan
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.
Iorns Elizabeth; Martens-de Kemp Sanne R; Lord Christopher J; Ashworth Alan
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.

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All Publications

2009: Mackay Alan; Tamber Narinder; Fenwick Kerry; Iravani Marjan; Grigoriadis Anita; Dexter Tim; Lord Christopher J; Reis-Filho Jorge S; Ashworth Alan
A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines.
Breast cancer research and treatment 2009;118(3):481-98.
2009: McCarthy Afshan; Lord Christopher J; Savage Kay; Grigoriadis Anita; Smith Darrin P; Weigelt Britta; Reis-Filho Jorge S; Ashworth Alan
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.
The Journal of pathology 2009;219(3):306-16.
2009: Iorns Elizabeth; Martens-de Kemp Sanne R; Lord Christopher J; Ashworth Alan
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
Carcinogenesis 2009;30(10):1696-701.
2009: Marchiò Caterina; Lambros Maryou B; Gugliotta Patrizia; Di Cantogno Ludovica Verdun; Botta Cristina; Pasini Barbara; Tan David S P; Mackay Alan; Fenwick Kerry; Tamber Narinder; Bussolati Gianni; Ashworth Alan; Reis-Filho Jorge S; Sapino Anna
Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis.
The Journal of pathology 2009;219(1):16-24.
2009: Oliver Antony W; Swift Sally; Lord Christopher J; Ashworth Alan; Pearl Laurence H
Structural basis for recruitment of BRCA2 by PALB2.
EMBO reports 2009;10(9):990-6.
2009: Westbury Charlotte B; Reis-Filho Jorge S; Dexter Tim; Mahler-Araujo Betania; Fenwick Kerry; Iravani Marjan; Grigoriadis Anita; Parry Suzanne; Robertson David; Mackay Alan; Ashworth Alan; Yarnold John R; Isacke Clare M
Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation.
The Journal of pathology 2009;219(1):131-40.
2009: Lambros M B K; Tan D S P; Jones R L; Vatcheva R; Savage K; Tamber N; Fenwick K; Mackay A; Ashworth A; Reis-Filho J S
Genomic profile of a secretory breast cancer with an ETV6-NTRK3 duplication.
Journal of clinical pathology 2009;62(7):604-12.
2009: Fong Peter C; Boss David S; Yap Timothy A; Tutt Andrew; Wu Peijun; Mergui-Roelvink Marja; Mortimer Peter; Swaisland Helen; Lau Alan; O'Connor Mark J; Ashworth Alan; Carmichael James; Kaye Stan B; Schellens Jan H M; de Bono Johann S
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.
The New England journal of medicine 2009;361(2):123-34.
2009: Marchiò Caterina; Iravani Marjan; Natrajan Rachael; Lambros Maryou B K; Geyer Felipe C; Savage Kay; Parry Suzanne; Tamber Narinder; Fenwick Kerry; Mackay Alan; Schmitt Fernando C; Bussolati Gianni; Ellis Ian; Ashworth Alan; Sapino Anna; Reis-Filho Jorge S
Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components.
The Journal of pathology 2009;218(3):301-15.
2009: Lord Christopher J; Ashworth Alan
Bringing DNA repair in tumors into focus.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3241-3.
2009: Natrajan Rachael; Lambros Maryou B; Rodríguez-Pinilla Socorro María; Moreno-Bueno Gema; Tan David S P; Marchió Caterina; Vatcheva Radost; Rayter Sydonia; Mahler-Araujo Betania; Fulford Laura G; Hungermann Daniela; Mackay Alan; Grigoriadis Anita; Fenwick Kerry; Tamber Narinder; Hardisson David; Tutt Andrew; Palacios Jose; Lord Christopher J; Buerger Horst; Ashworth Alan; Reis-Filho Jorge S
Tiling path genomic profiling of grade 3 invasive ductal breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2711-22.
2009: Tan David S P; Lambros Maryou B K; Rayter Sydonia; Natrajan Rachael; Vatcheva Radost; Gao Qiong; Marchiò Caterina; Geyer Felipe C; Savage Kay; Parry Suzanne; Fenwick Kerry; Tamber Narinder; Mackay Alan; Dexter Tim; Jameson Charles; McCluggage W Glenn; Williams Alistair; Graham Ashley; Faratian Dana; El-Bahrawy Mona; Paige Adam J; Gabra Hani; Gore Martin E; Zvelebil Marketa; Lord Christopher J; Kaye Stanley B; Ashworth Alan; Reis-Filho Jorge S
PPM1D is a potential therapeutic target in ovarian clear cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2269-80.
2009: Natrajan Rachael; Lambros Maryou B K; Geyer Felipe C; Marchio Caterina; Tan David S P; Vatcheva Radost; Shiu Kai-Keen; Hungermann Daniela; Rodriguez-Pinilla Socorro Maria; Palacios Jose; Ashworth Alan; Buerger Horst; Reis-Filho Jorge S
Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?
Genes, chromosomes & cancer 2009;48(4):351-65.
2009: McCabe N; Cerone M A; Ohishi T; Seimiya H; Lord C J; Ashworth A
Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.
Oncogene 2009;28(11):1465-70.
2009: Lord C J; Martin S A; Ashworth A
RNA interference screening demystified.
Journal of clinical pathology 2009;62(3):195-200.
2009: Fletcher Olivia; Johnson Nichola; Dos Santos Silva Isabel; Kilpivaara Outi; Aittomäki Kristiina; Blomqvist Carl; Nevanlinna Heli; Wasielewski Marijke; Meijers-Heijerboer Hanne; Broeks Annegien; Schmidt Marjanka K; Van't Veer Laura J; Bremer Michael; Dörk Thilo; Chekmariova Elena V; Sokolenko Anna P; Imyanitov Evgeny N; Hamann Ute; Rashid Muhammad U; Brauch Hiltrud; Justenhoven Christina; Ashworth Alan; Peto Julian
Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(1):230-4.
2009: Iorns Elizabeth; Lord Christopher J; Ashworth Alan
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization.
The Biochemical journal 2009;417(1):361-70.
2009: Britt Kara L; Kendrick Howard; Regan Joseph L; Molyneux Gemma; Magnay Fiona-Ann; Ashworth Alan; Smalley Matthew J
Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells.
Breast cancer research : BCR 2009;11(2):R20.
2009: Iorns Elizabeth; Lord Christopher J; Grigoriadis Anita; McDonald Sarah; Fenwick Kerry; Mackay Alan; Mein Charles A; Natrajan Rachael; Savage Kay; Tamber Narinder; Reis-Filho Jorge S; Turner Nicholas C; Ashworth Alan
Integrated functional, gene expression and genomic analysis for the identification of cancer targets.
PloS one 2009;4(4):e5120.
2008: Vuononvirta Raisa; Sebire Neil J; Dallosso Anthony R; Reis-Filho Jorge S; Williams Richard D; Mackay Alan; Fenwick Kerry; Grigoriadis Anita; Ashworth Alan; Pritchard-Jones Kathy; Brown Keith W; Vujanic Gordan M; Jones Chris
Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7635-44.
2008: Tutt Andrew; Ashworth Alan
Can genetic testing guide treatment in breast cancer?
European journal of cancer (Oxford, England : 1990) 2008;44(18):2774-80.
2008: Lord Christopher J; McDonald Sarah; Swift Sally; Turner Nicholas C; Ashworth Alan
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity.
DNA repair 2008;7(12):2010-9.
2008: Marchiò C; Natrajan R; Shiu K K; Lambros M B K; Rodriguez-Pinilla S M; Tan D S P; Lord C J; Hungermann D; Fenwick K; Tamber N; Mackay A; Palacios J; Sapino A; Buerger H; Ashworth A; Reis-Filho J S
The genomic profile of HER2-amplified breast cancers: the influence of ER status.
The Journal of pathology 2008;216(4):399-407.
2008: Towler Mhairi C; Fogarty Sarah; Hawley Simon A; Pan David A; Martin David M A; Morrice Nicolas A; McCarthy Afshan; Galardo María N; Meroni Silvina B; Cigorraga Selva B; Ashworth Alan; Sakamoto Kei; Hardie D Grahame
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis.
The Biochemical journal 2008;416(1):1-14.
2008: Lord Christopher J; Ashworth Alan
Targeted therapy for cancer using PARP inhibitors.
Current opinion in pharmacology 2008;8(4):363-9.
2008: Ashworth Alan
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(22):3785-90.
2008: Marchiò C; Iravani M; Natrajan R; Lambros M B; Savage K; Tamber N; Fenwick K; Mackay A; Senetta R; Di Palma S; Schmitt F C; Bussolati G; Ellis L O; Ashworth A; Sapino A; Reis-Filho J S
Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast.
The Journal of pathology 2008;215(4):398-410.
2008: Lord Christopher J; Iorns Elizabeth; Ashworth Alan
Dissecting resistance to endocrine therapy in breast cancer.
Cell cycle (Georgetown, Tex.) 2008;7(13):1895-8.
2008: Simpson P T; Reis-Filho J S; Lambros M B K; Jones C; Steele D; Mackay A; Iravani M; Fenwick K; Dexter T; Jones A; Reid L; Da Silva L; Shin S J; Hardisson D; Ashworth A; Schmitt F C; Palacios J; Lakhani S R
Molecular profiling pleomorphic lobular carcinomas of the breast: evidence for a common molecular genetic pathway with classic lobular carcinomas.
The Journal of pathology 2008;215(3):231-44.
2008: Turner Nicholas C; Lord Christopher J; Iorns Elizabeth; Brough Rachel; Swift Sally; Elliott Richard; Rayter Sydonia; Tutt Andrew N; Ashworth Alan
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
The EMBO journal 2008;27(9):1368-77.
2008: Arriola Edurne; Marchio Caterina; Tan David S P; Drury Suzanne C; Lambros Maryou B; Natrajan Rachael; Rodriguez-Pinilla Socorro Maria; Mackay Alan; Tamber Narinder; Fenwick Kerry; Jones Chris; Dowsett Mitch; Ashworth Alan; Reis-Filho Jorge S
Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.
Laboratory investigation; a journal of technical methods and pathology 2008;88(5):491-503.
2008: Palles Claire; Johnson Nichola; Coupland Ben; Taylor Claire; Carvajal Jaime; Holly Jeff; Fentiman Ian S; Silva Isabel dos Santos; Ashworth Alan; Peto Julian; Fletcher Olivia
Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy.
Human molecular genetics 2008;17(10):1457-64.
2008: Smalley Matthew J; Reis-Filho Jorge S; Ashworth Alan
BRCA1 and stem cells: tumour typecasting.
Nature cell biology 2008;10(4):377-9.
2008: Wansbury Olivia; Panchal Heena; James Michelle; Parry Suzanne; Ashworth Alan; Howard Beatrice
Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.
The Journal of investigative dermatology 2008;128(4):1009-21.
2008: Fletcher Olivia; Johnson Nichola; Gibson Lorna; Coupland Ben; Fraser Agnes; Leonard Angela; dos Santos Silva Isabel; Ashworth Alan; Houlston Richard; Peto Julian
Association of genetic variants at 8q24 with breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008;17(3):702-5.
2008: Ashworth Alan; Balkwill Frances; Bast Robert C; Berek Jonathan S; Kaye Allyson; Boyd Jeffrey A; Mills Gordon; Weinstein John N; Woolley Katie; Workman Paul
Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007.
Gynecologic oncology 2008;108(3):652-7.
2008: Martin Sarah A; Lord Christopher J; Ashworth Alan
DNA repair deficiency as a therapeutic target in cancer.
Current opinion in genetics & development 2008;18(1):80-6.
2008: Edwards Stacey L; Brough Rachel; Lord Christopher J; Natrajan Rachael; Vatcheva Radost; Levine Douglas A; Boyd Jeff; Reis-Filho Jorge S; Ashworth Alan
Resistance to therapy caused by intragenic deletion in BRCA2.
Nature 2008;451(7182):1111-5.
2008: Iorns Elizabeth; Turner Nicholas C; Elliott Richard; Syed Nelofer; Garrone Ornella; Gasco Milena; Tutt Andrew N J; Crook Tim; Lord Christopher J; Ashworth Alan
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
Cancer cell 2008;13(2):91-104.
2008: Rayter S; Elliott R; Travers J; Rowlands M G; Richardson T B; Boxall K; Jones K; Linardopoulos S; Workman P; Aherne W; Lord C J; Ashworth A
A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
Oncogene 2008;27(8):1036-44.
2008: Brough Rachel; Wei Debbie; Leulier Sophie; Lord Christopher J; Rong Yikang S; Ashworth Alan
Functional analysis of Drosophila melanogaster BRCA2 in DNA repair.
DNA repair 2008;7(1):10-9.
2007: Britt Kara; Ashworth Alan; Smalley Matthew
Pregnancy and the risk of breast cancer.
Endocrine-related cancer 2007;14(4):907-33.
2007: Gudmundsdottir K; Lord C J; Ashworth A
The proteasome is involved in determining differential utilization of double-strand break repair pathways.
Oncogene 2007;26(54):7601-6.
2007: Banerjee Susana; Dowsett Mitch; Ashworth Alan; Martin Lesley-Ann
Mechanisms of disease: angiogenesis and the management of breast cancer.
Nature clinical practice. Oncology 2007;4(9):536-50.
2007: Iorns Elizabeth; Lord Christopher J; Turner Nicholas; Ashworth Alan
Utilizing RNA interference to enhance cancer drug discovery.
Nature reviews. Drug discovery 2007;6(7):556-68.
2007: Lord Christopher J; Ashworth Alan
RAD51, BRCA2 and DNA repair: a partial resolution.
Nature structural & molecular biology 2007;14(6):461-2.
2007: Jones Michael E; Folkerd Elizabeth J; Doody Deborah A; Iqbal Jhangir; Dowsett Mitch; Ashworth Alan; Swerdlow Anthony J
Effect of delays in processing blood samples on measured endogenous plasma sex hormone levels in women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(6):1136-9.
2007: Natrajan Rachael; Williams Richard D; Grigoriadis Anita; Mackay Alan; Fenwick Kerry; Ashworth Alan; Dome Jeffrey S; Grundy Paul E; Pritchard-Jones Kathy; Jones Chris
Delineation of a 1Mb breakpoint region at 1p13 in Wilms tumors by fine-tiling oligonucleotide array CGH.
Genes, chromosomes & cancer 2007;46(6):607-15.
2007: Johnson Nichola; Fletcher Olivia; Palles Claire; Rudd Matthew; Webb Emily; Sellick Gabrielle; dos Santos Silva Isabel; McCormack Valerie; Gibson Lorna; Fraser Agnes; Leonard Angela; Gilham Clare; Tavtigian Sean V; Ashworth Alan; Houlston Richard; Peto Julian
Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility.
Human molecular genetics 2007;16(9):1051-7.
2007: Di Palma Silvana; Lambros Maryou B K; Savage Kay; Jones Chris; Mackay Alan; Dexter Tim; Iravani Marjan; Fenwick Kerry; Ashworth Alan; Reis-Filho Jorge S
Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells.
Journal of clinical pathology 2007;60(5):492-9.
2007: Tischkowitz Marc; Xia Bing; Sabbaghian Nelly; Reis-Filho Jorge S; Hamel Nancy; Li Guilan; van Beers Erik H; Li Lili; Khalil Tayma; Quenneville Louise A; Omeroglu Atilla; Poll Aletta; Lepage Pierre; Wong Nora; Nederlof Petra M; Ashworth Alan; Tonin Patricia N; Narod Steven A; Livingston David M; Foulkes William D
Analysis of PALB2/FANCN-associated breast cancer families.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(16):6788-93.
2007: Takeda Shintaro; Iwai Atsushi; Nakashima Mitsuko; Fujikura Daisuke; Chiba Satoko; Li Hong Mei; Uehara Jun; Kawaguchi Satoshi; Kaya Mitsunori; Nagoya Satoshi; Wada Takuro; Yuan Junying; Rayter Sydonia; Ashworth Alan; Reed John C; Yamashita Toshihiko; Uede Toshimitsu; Miyazaki Tadaaki
LKB1 is crucial for TRAIL-mediated apoptosis induction in osteosarcoma.
Anticancer research 2007;27(2):761-8.
2007: McCarthy A; Savage K; Gabriel A; Naceur C; Reis-Filho J S; Ashworth A
A mouse model of basal-like breast carcinoma with metaplastic elements.
The Journal of pathology 2007;211(4):389-98.
2007: Turner N C; Reis-Filho J S; Russell A M; Springall R J; Ryder K; Steele D; Savage K; Gillett C E; Schmitt F C; Ashworth A; Tutt A N
BRCA1 dysfunction in sporadic basal-like breast cancer.
Oncogene 2007;26(14):2126-32.
2007: Savage Kay; Lambros Maryou B K; Robertson David; Jones Robin L; Jones Chris; Mackay Alan; James Michelle; Hornick Jason L; Pereira Emilio M; Milanezi Fernanda; Fletcher Christopher D M; Schmitt Fernando C; Ashworth Alan; Reis-Filho Jorge S
Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):90-101.
2007: Sleeman Katherine E; Kendrick Howard; Robertson David; Isacke Clare M; Ashworth Alan; Smalley Matthew J
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.
The Journal of cell biology 2007;176(1):19-26.
2007: Arriola Edurne; Lambros Maryou B K; Jones Chris; Dexter Tim; Mackay Alan; Tan David S P; Tamber Narinder; Fenwick Kerry; Ashworth Alan; Dowsett Mitch; Reis-Filho Jorge S
Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):75-83.
2007: Pierga J-Y; Reis-Filho J S; Cleator S J; Dexter T; Mackay A; Simpson P; Fenwick K; Iravani M; Salter J; Hills M; Jones C; Ashworth A; Smith I E; Powles T; Dowsett M
Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
British journal of cancer 2007;96(2):341-51.
2007: Natrajan R; Little S E; Sodha N; Reis-Filho J S; Mackay A; Fenwick K; Ashworth A; Perlman E J; Dome J S; Grundy P E; Pritchard-Jones K; Jones C
Analysis by array CGH of genomic changes associated with the progression or relapse of Wilms' tumour.
The Journal of pathology 2007;211(1):52-9.
2007: Smalley Matthew J; Iravani Marjan; Leao Maria; Grigoriadis Anita; Kendrick Howard; Dexter Tim; Fenwick Kerry; Regan Joseph L; Britt Kara; McDonald Sarah; Lord Christopher J; Mackay Alan; Ashworth Alan
Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.
Breast cancer research : BCR 2007;9(6):R85.
2007: Panchal Heena; Wansbury Olivia; Parry Suzanne; Ashworth Alan; Howard Beatrice
Neuregulin3 alters cell fate in the epidermis and mammary gland.
BMC developmental biology 2007;7():105.
2007: Mackay Alan; Urruticoechea Ander; Dixon J Michael; Dexter Tim; Fenwick Kerry; Ashworth Alan; Drury Suzanne; Larionov Alexey; Young Oliver; White Sharon; Miller William R; Evans Dean B; Dowsett Mitch
Molecular response to aromatase inhibitor treatment in primary breast cancer.
Breast cancer research : BCR 2007;9(3):R37.
2006: Reis-Filho Jorge Sergio; Simpson Pete T; Turner Nicholas C; Lambros Maryou Ballo; Jones Chris; Mackay Alan; Grigoriadis Anita; Sarrio David; Savage Kay; Dexter Tim; Iravani Marjan; Fenwick Kerry; Weber Barbara; Hardisson David; Schmitt Fernando Carlos; Palacios Jose; Lakhani Sunil R; Ashworth Alan
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6652-62.
2006: Gudmundsdottir K; Ashworth A
The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.
Oncogene 2006;25(43):5864-74.
2006: Natrajan R; Williams R D; Hing S N; Mackay A; Reis-Filho J S; Fenwick K; Iravani M; Valgeirsson H; Grigoriadis A; Langford C F; Dovey O; Gregory S G; Weber B L; Ashworth A; Grundy P E; Pritchard-Jones K; Jones C
Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse.
The Journal of pathology 2006;210(1):49-58.
2006: Howard Beatrice; Ashworth Alan
Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.
PLoS genetics 2006;2(8):e112.
2006: McCabe Nuala; Turner Nicholas C; Lord Christopher J; Kluzek Katarzyna; Bialkowska Aneta; Swift Sally; Giavara Sabrina; O'Connor Mark J; Tutt Andrew N; Zdzienicka Malgorzata Z; Smith Graeme C M; Ashworth Alan
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
Cancer research 2006;66(16):8109-15.
2006: Lord Christopher J; Garrett Michelle D; Ashworth Alan
Targeting the double-strand DNA break repair pathway as a therapeutic strategy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4463-8.
2006: Reis-Filho J S; Pinheiro C; Lambros M B K; Milanezi F; Carvalho S; Savage K; Simpson P T; Jones C; Swift S; Mackay A; Reis R M; Hornick J L; Pereira E M; Baltazar F; Fletcher C D M; Ashworth A; Lakhani S R; Schmitt F C
EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.
The Journal of pathology 2006;209(4):445-53.
2006: Fletcher Olivia; Johnson Nichola; Palles Claire; dos Santos Silva Isabel; McCormack Valerie; Whittaker John; Ashworth Alan; Peto Julian
Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk.
Journal of the National Cancer Institute 2006;98(14):1014-8.
2006: Banerjee S; Reis-Filho J S; Ashley S; Steele D; Ashworth A; Lakhani S R; Smith I E
Basal-like breast carcinomas: clinical outcome and response to chemotherapy.
Journal of clinical pathology 2006;59(7):729-35.
2006: Horsley Sharon W; Mackay Alan; Iravani Marjan; Fenwick Kerry; Valgeirsson Haukur; Dexter Tim; Ashworth Alan; Kearney Lyndal
Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
Genes, chromosomes & cancer 2006;45(6):554-64.
2006: Sakamoto Kei; Zarrinpashneh Elham; Budas Grant R; Pouleur Anne-Catherine; Dutta Anindya; Prescott Alan R; Vanoverschelde Jean-Louis; Ashworth Alan; Jovanovic Aleksandar; Alessi Dario R; Bertrand Luc
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E780-8.
2006: Lambros Maryou B K; Simpson Pete T; Jones Chris; Natrajan Rachael; Westbury Charlotte; Steele Dawn; Savage Kay; Mackay Alan; Schmitt Fernando C; Ashworth Alan; Reis-Filho Jorge S
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Laboratory investigation; a journal of technical methods and pathology 2006;86(4):398-408.
2006: Balkwill Frances R; Ashworth Alan; Bast Robert C; Berek Jonathon S; Boyd Jeff; Disis Mary L; Gabra Hani; Gore Martin E; Hamilton Thomas C; Jacobs Ian J; Kaye Stan B; Kohn Elise C; Mills Gordon B; Urban Nicole D
10th Biennial Helene Harris Memorial Trust meeting.
Cancer research 2006;66(6):2904-6.
2006: Friedmann Benjamin J; Caplin Martyn; Savic Boris; Shah Tahir; Lord Christopher J; Ashworth Alan; Hartley John A; Hochhauser Daniel
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Molecular cancer therapeutics 2006;5(2):209-18.
2006: Reis-Filho Jorge S; Steele Dawn; Di Palma Silvana; Jones Robin L; Savage Kay; James Michelle; Milanezi Fernanda; Schmitt Fernando C; Ashworth Alan
Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(2):307-19.
2006: Cleator Susan; Tsimelzon Anna; Ashworth Alan; Dowsett Mitch; Dexter Timothy; Powles Trevor; Hilsenbeck Susan; Wong Helen; Osborne C Kent; O'Connell Peter; Chang Jenny C
Gene expression patterns for doxorubicin (Adriamycin) and cyclophosphamide (cytoxan) (AC) response and resistance.
Breast cancer research and treatment 2006;95(3):229-33.
2006: Arias-Lopez Carmen; Lazaro-Trueba Iciar; Kerr Peter; Lord Christopher J; Dexter Tim; Iravani Marjan; Ashworth Alan; Silva Augusto
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
EMBO reports 2006;7(2):219-24.
2006: Little Suzanne E; Vuononvirta Raisa; Reis-Filho Jorge S; Natrajan Rachael; Iravani Marjan; Fenwick Kerry; Mackay Alan; Ashworth Alan; Pritchard-Jones Kathy; Jones Chris
Array CGH using whole genome amplification of fresh-frozen and formalin-fixed, paraffin-embedded tumor DNA.
Genomics 2006;87(2):298-306.
2006: Grigoriadis Anita; Mackay Alan; Reis-Filho Jorge S; Steele Dawn; Iseli Christian; Stevenson Brian J; Jongeneel C Victor; Valgeirsson Haukur; Fenwick Kerry; Iravani Marjan; Leao Maria; Simpson Andrew J G; Strausberg Robert L; Jat Parmjit S; Ashworth Alan; Neville A Munro; O'Hare Michael J
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.
Breast cancer research : BCR 2006;8(5):R56.
2006: Cleator Susan J; Powles Trevor J; Dexter Tim; Fulford Laura; Mackay Alan; Smith Ian E; Valgeirsson Haukur; Ashworth Alan; Dowsett Mitch
The effect of the stromal component of breast tumours on prediction of clinical outcome using gene expression microarray analysis.
Breast cancer research : BCR 2006;8(3):R32.
2006: Sleeman Katherine E; Kendrick Howard; Ashworth Alan; Isacke Clare M; Smalley Matthew J
CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells.
Breast cancer research : BCR 2006;8(1):R7.
2005: Johnson Nichola; Fletcher Olivia; Naceur-Lombardelli Cristina; dos Santos Silva Isabel; Ashworth Alan; Peto Julian
Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study.
Lancet 2005;366(9496):1554-7.
2005: Sowter Heidi M; Ashworth Alan
BRCA1 and BRCA2 as ovarian cancer susceptibility genes.
Carcinogenesis 2005;26(10):1651-6.
2005: McCabe Nuala; Lord Christopher J; Tutt Andrew N J; Martin Niall M B; Smith Graeme C M; Ashworth Alan
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
Cancer biology & therapy 2005;4(9):934-6.
2005: Howard Beatrice; Panchal Heena; McCarthy Afshan; Ashworth Alan
Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
Genes & development 2005;19(17):2078-90.
2005: Reis-Filho Jorge S; Simpson Pete T; Jones Chris; Steele Dawn; Mackay Alan; Iravani Marjan; Fenwick Kerry; Valgeirsson Haukur; Lambros Maryou; Ashworth Alan; Palacios Jose; Schmitt Fernando; Lakhani Sunil R
Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity.
The Journal of pathology 2005;207(1):1-13.
2005: Ashworth Alan
Oh what a tangled web it weaves: BRCA1 and DNA decatenation.
Cancer cell 2005;8(2):95-7.
2005: Turner Nicholas; Tutt Andrew; Ashworth Alan
Targeting the DNA repair defect of BRCA tumours.
Current opinion in pharmacology 2005;5(4):388-93.
2005: Sakamoto Kei; McCarthy Afshan; Smith Darrin; Green Kevin A; Grahame Hardie D; Ashworth Alan; Alessi Dario R
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.
The EMBO journal 2005;24(10):1810-20.
2005: Farmer Hannah; McCabe Nuala; Lord Christopher J; Tutt Andrew N J; Johnson Damian A; Richardson Tobias B; Santarosa Manuela; Dillon Krystyna J; Hickson Ian; Knights Charlotte; Martin Niall M B; Jackson Stephen P; Smith Graeme C M; Ashworth Alan
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Nature 2005;434(7035):917-21.
2005: Fletcher Olivia; Gibson Lorna; Johnson Nichola; Altmann Dan R; Holly Jeffrey M P; Ashworth Alan; Peto Julian; Silva Isabel Dos Santos
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):2-19.
2005: Kenny Paraic A; Enver Tariq; Ashworth Alan
Receptor and secreted targets of Wnt-1/beta-catenin signalling in mouse mammary epithelial cells.
BMC cancer 2005;5():3.
2005: Tutt A N J; Lord C J; McCabe N; Farmer H; Turner N; Martin N M; Jackson S P; Smith G C M; Ashworth A
Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer.
Cold Spring Harbor symposia on quantitative biology 2005;70():139-48.
2005: Smalley M J; Titley I; Ashworth A
An improved definition of mouse mammary epithelial side population cells.
Cytotherapy 2005;7(6):497-508.
2005: Brookman-Amissah N; Duchesnes C; Williamson M P; Wang Q; Ahmed A; Feneley M R; Mackay A; Freeman A; Fenwick K; Iravani M; Weber B; Ashworth A; Masters J R
Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH.
Prostate cancer and prostatic diseases 2005;8(4):335-43.
2004: Rahman Nazneen; Ashworth Alan
A new gene on the X involved in Fanconi anemia.
Nature genetics 2004;36(11):1142-3.
2004: Turner Nicholas; Tutt Andrew; Ashworth Alan
Hallmarks of 'BRCAness' in sporadic cancers.
Nature reviews. Cancer 2004;4(10):814-9.
2004: Ashworth Alan
Refocusing on BRCA1.
Nature cell biology 2004;6(10):916-7.
2004: Gudmundsdottir Katrin; Lord Christopher J; Witt Emily; Tutt Andrew N J; Ashworth Alan
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.
EMBO reports 2004;5(10):989-93.
2004: Gudmundsdottir Katrin; Ashworth Alan
BRCA2 in meiosis: turning over a new leaf.
Trends in cell biology 2004;14(8):401-4.
2004: Santarosa Manuela; Ashworth Alan
Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way.
Biochimica et biophysica acta 2004;1654(2):105-22.
2004: Hussain Shobbir; Wilson James B; Medhurst Annette L; Hejna James; Witt Emily; Ananth Sahana; Davies Adelina; Masson Jean-Yves; Moses Robb; West Stephen C; de Winter Johan P; Ashworth Alan; Jones Nigel J; Mathew Christopher G
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
Human molecular genetics 2004;13(12):1241-8.
2004: Spicer James; Ashworth Alan
LKB1 kinase: master and commander of metabolism and polarity.
Current biology : CB 2004;14(10):R383-5.
2004: Cleator S; Ashworth A
Molecular profiling of breast cancer: clinical implications.
British journal of cancer 2004;90(6):1120-4.
2003: Smalley Matthew; Ashworth Alan
Stem cells and breast cancer: A field in transit.
Nature reviews. Cancer 2003;3(11):832-44.
2003: Tutt Andrew; Ashworth Alan
Close relatives or distant cousins?
The lancet oncology 2003;4(10):593-4.
2003: Warren Madhuri; Lord Christopher J; Masabanda Julio; Griffin Darren; Ashworth Alan
Phenotypic effects of heterozygosity for a BRCA2 mutation.
Human molecular genetics 2003;12(20):2645-56.
2003: Hussain Shobbir; Witt Emily; Huber Pia A J; Medhurst Annette L; Ashworth Alan; Mathew Christopher G
Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1.
Human molecular genetics 2003;12(19):2503-10.
2003: Trompouki Eirini; Hatzivassiliou Eudoxia; Tsichritzis Theodore; Farmer Hannah; Ashworth Alan; Mosialos George
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
Nature 2003;424(6950):793-6.
2003: Dowsett Mitch; Ashworth Alan
New biology of the oestrogen receptor.
Lancet 2003;362(9380):260-2.
2003: Spicer James; Rayter Sydonia; Young Neville; Elliott Richard; Ashworth Alan; Smith Darrin
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1.
Oncogene 2003;22(30):4752-6.
2003: East Lucy; McCarthy Afshan; Wienke Dirk; Sturge Justin; Ashworth Alan; Isacke Clare M
A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.
EMBO reports 2003;4(7):710-6.
2003: Foray Nicolas; Marot Didier; Gabriel Anastasia; Randrianarison Voahangy; Carr Antony M; Perricaudet Michel; Ashworth Alan; Jeggo Penny
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
The EMBO journal 2003;22(11):2860-71.
2003: Tutt Andrew; Connor Frances; Bertwistle David; Kerr Peter; Peacock John; Ross Gill; Ashworth Alan
Cell cycle and genetic background dependence of the effect of loss of BRCA2 on ionizing radiation sensitivity.
Oncogene 2003;22(19):2926-31.
2003: Stone Caroline; McCabe Nuala; Ashworth Alan
X-chromosome inactivation: X marks the spot for BRCA1.
Current biology : CB 2003;13(2):R63-4.
2003: Alvi Azra J; Clayton Helen; Joshi Chirag; Enver Tariq; Ashworth Alan; Vivanco Maria d M; Dale Trevor C; Smalley Matthew J
Functional and molecular characterisation of mammary side population cells.
Breast cancer research : BCR 2003;5(1):R1-8.
2002: Tutt Andrew; Ashworth Alan
The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.
Trends in molecular medicine 2002;8(12):571-6.
2002: Vidarsson H; Mikaelsdottir E K; Rafnar T; Bertwistle D; Ashworth A; Eyfjord J E; Valgeirsdottir S
BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity.
FEBS letters 2002;532(1-2):247-52.
2002: Kenny Paraic A; Enver Tariq; Ashworth Alan
Retroviral vectors for establishing tetracycline-regulated gene expression in an otherwise recalcitrant cell line.
BMC molecular biology 2002;3():13.
2002: Witt Emily; Ashworth Alan
Biomedicine. D-Day for BRCA2.
Science (New York, N.Y.) 2002;297(5581):534.
2002: Theodosiou Aspasia; Ashworth Alan
MAP kinase phosphatases.
Genome biology 2002;3(7):REVIEWS3009.
2002: Theodosiou Aspasia; Ashworth Alan
Differential effects of stress stimuli on a JNK-inactivating phosphatase.
Oncogene 2002;21(15):2387-97.
2002: Warren Madhuri; Smith Amanda; Partridge Natalie; Masabanda Julio; Griffin Darren; Ashworth Alan
Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations.
Human molecular genetics 2002;11(7):841-51.
2002: Tutt Andrew N J; van Oostrom Conny Th M; Ross Gillian M; van Steeg Harry; Ashworth Alan
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation.
EMBO reports 2002;3(3):255-60.
2001: Smith D P; Rayter S I; Niederlander C; Spicer J; Jones C M; Ashworth A
LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.
Human molecular genetics 2001;10(25):2869-77.
2001: Lakhani S R; Ashworth A
Microarray and histopathological analysis of tumours: the future and the past?
Nature reviews. Cancer 2001;1(2):151-7.
2001: Perry J; Palmer S; Gabriel A; Ashworth A
A short pseudoautosomal region in laboratory mice.
Genome research 2001;11(11):1826-32.
2001: Tutt A; Bertwistle D; Valentine J; Gabriel A; Swift S; Ross G; Griffin C; Thacker J; Ashworth A
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.
The EMBO journal 2001;20(17):4704-16.
2001: Kerr P; Ashworth A
New complexities for BRCA1 and BRCA2.
Current biology : CB 2001;11(16):R668-76.
2001: Lakhani S R; O'Hare M J; Ashworth A
Profiling familial breast cancer.
Nature medicine 2001;7(4):408-10.
2000: Bertwistle D; Ashworth A
BRCA1 and BRCA2.
Current biology : CB 2000;10(16):R582.
2000: Romer J T; Ashworth A
The upstream region of the mouse xist gene contains two ribosomal protein pseudogenes.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(6):461-3.
2000: de Martino S; Yan Y L; Jowett T; Postlethwait J H; Varga Z M; Ashworth A; Austin C A
Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;217(3):279-92.
2000: Sheikh H; Yarwood H; Ashworth A; Isacke C M
Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor.
Journal of cell science 2000;113 ( Pt 6)():1021-32.
1999: Perry J; Short K M; Romer J T; Swift S; Cox T C; Ashworth A
FXY2/MID2, a gene related to the X-linked Opitz syndrome gene FXY/MID1, maps to Xq22 and encodes a FNIII domain-containing protein that associates with microtubules.
Genomics 1999;62(3):385-94.
1999: Theodosiou A; Smith A; Gillieron C; Arkinstall S; Ashworth A
MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.
Oncogene 1999;18(50):6981-8.
1999: Smith A; Smith A; Alrubaie S; Coehlo C; Leevers S J; Ashworth A
Alternative splicing of the Drosophila PTEN gene.
Biochimica et biophysica acta 1999;1447(2-3):313-7.
1999: Tutt A; Gabriel A; Bertwistle D; Connor F; Paterson H; Peacock J; Ross G; Ashworth A
Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification.
Current biology : CB 1999;9(19):1107-10.
1999: Perry J; Ashworth A
Evolutionary rate of a gene affected by chromosomal position.
Current biology : CB 1999;9(17):987-9.
1999: Smith D P; Spicer J; Smith A; Swift S; Ashworth A
The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase.
Human molecular genetics 1999;8(8):1479-85.
1999: Marston N J; Richards W J; Hughes D; Bertwistle D; Marshall C J; Ashworth A
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
Molecular and cellular biology 1999;19(7):4633-42.
1999: Low W; Smith A; Ashworth A; Collins M
JNK activation is not required for Fas-mediated apoptosis.
Oncogene 1999;18(25):3737-41.
1999: De Martino S P; Errington F; Ashworth A; Jowett T; Austin C A
sox30: a novel zebrafish sox gene expressed in a restricted manner at the midbrain-hindbrain boundary during neurogenesis.
Development genes and evolution 1999;209(6):357-62.
1999: Bertwistle D; Ashworth A
The pathology of familial breast cancer: How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?
Breast cancer research : BCR 1999;1(1):41-7.
1998: Korobova O; Lane P W; Perry J; Palmer S; Ashworth A; Davisson M T; Arnheim N
Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region.
Genomics 1998;54(3):556-9.
1998: Swift S; Blackburn C; Morahan G; Ashworth A
Structure and chromosomal mapping of the TNF-alpha inducible endothelial protein 1 (Edp1) gene in the mouse.
Biochimica et biophysica acta 1998;1442(2-3):394-8.
1998: Roth S; Kristo P; Auranen A; Shayehgi M; Seal S; Collins N; Barfoot R; Rahman N; Klemi P J; Grénman S; Sarantaus L; Nevanlinna H; Butzow R; Ashworth A; Stratton M R; Aaltonen L A
A missense mutation in the BRCA2 gene in three siblings with ovarian cancer.
British journal of cancer 1998;77(8):1199-202.
1998: Muda M; Theodosiou A; Gillieron C; Smith A; Chabert C; Camps M; Boschert U; Rodrigues N; Davies K; Ashworth A; Arkinstall S
The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity.
The Journal of biological chemistry 1998;273(15):9323-9.
1998: Smith A; Ashworth A
Cancer predisposition: where's the phosphate?
Current biology : CB 1998;8(7):R241-3.
1998: Bertwistle D; Ashworth A
Functions of the BRCA1 and BRCA2 genes.
Current opinion in genetics & development 1998;8(1):14-20.
1998: Perry J; Feather S; Smith A; Palmer S; Ashworth A
The human FXY gene is located within Xp22.3: implications for evolution of the mammalian X chromosome.
Human molecular genetics 1998;7(2):299-305.
1998: Burgoyne P S; Mahadevaiah S K; Perry J; Palmer S J; Ashworth A
The Y* rearrangement in mice: new insights into a perplexing PAR.
Cytogenetics and cell genetics 1998;80(1-4):37-40.
1997: Bertwistle D; Swift S; Marston N J; Jackson L E; Crossland S; Crompton M R; Marshall C J; Ashworth A
Nuclear location and cell cycle regulation of the BRCA2 protein.
Cancer research 1997;57(24):5485-8.
1997: Connor F; Bertwistle D; Mee P J; Ross G M; Swift S; Grigorieva E; Tybulewicz V L; Ashworth A
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation.
Nature genetics 1997;17(4):423-30.
1997: Smith A; Ramos-Morales F; Ashworth A; Collins M
A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells.
Current biology : CB 1997;7(11):893-6.
1997: Alessi D R; Deak M; Casamayor A; Caudwell F B; Morrice N; Norman D G; Gaffney P; Reese C B; MacDougall C N; Harbison D; Ashworth A; Bownes M
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Current biology : CB 1997;7(10):776-89.
1997: Palmer S; Perry J; Kipling D; Ashworth A
A gene spans the pseudoautosomal boundary in mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):12030-5.
1997: Smith A; Price C; Cullen M; Muda M; King A; Ozanne B; Arkinstall S; Ashworth A
Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7).
Genomics 1997;42(3):524-7.
1997: Herzing L B; Romer J T; Horn J M; Ashworth A
Xist has properties of the X-chromosome inactivation centre.
Nature 1997;386(6622):272-5.
1997: Connor F; Smith A; Wooster R; Stratton M; Dixon A; Campbell E; Tait T M; Freeman T; Ashworth A
Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene.
Human molecular genetics 1997;6(2):291-300.
1997: Muda M; Boschert U; Smith A; Antonsson B; Gillieron C; Chabert C; Camps M; Martinou I; Ashworth A; Arkinstall S
Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4.
The Journal of biological chemistry 1997;272(8):5141-51.
1997: Bignell G; Micklem G; Stratton M R; Ashworth A; Wooster R
The BRC repeats are conserved in mammalian BRCA2 proteins.
Human molecular genetics 1997;6(1):53-8.
1996: Muda M; Theodosiou A; Rodrigues N; Boschert U; Camps M; Gillieron C; Davies K; Ashworth A; Arkinstall S
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases.
The Journal of biological chemistry 1996;271(44):27205-8.
1996: Wunderle V M; Critcher R; Ashworth A; Goodfellow P N
Cloning and characterization of SOX5, a new member of the human SOX gene family.
Genomics 1996;36(2):354-8.
1996: Garcia-Marco J A; Caldas C; Price C M; Wiedemann L M; Ashworth A; Catovsky D
Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia.
Blood 1996;88(5):1568-75.
1996: Bogoyevitch M A; Gillespie-Brown J; Ketterman A J; Fuller S J; Ben-Levy R; Ashworth A; Marshall C J; Sugden P H
Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion.
Circulation research 1996;79(2):162-73.
1996: Chiang P W; Baldacci P A; Babinet C; Camper S A; Watkins-Chow D; Baker D D; Tsai C H; Ramamoorthy S; King E; Slack A C; Fogel E; Morahan G; Ashworth A; Blackburn C C; Kurnit D M
Linkage mapping of murine homolog of the yeast SPT6 gene to MMU11B1.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(6):459-60.
1996: Lancaster J M; Wooster R; Mangion J; Phelan C M; Cochran C; Gumbs C; Seal S; Barfoot R; Collins N; Bignell G; Patel S; Hamoudi R; Larsson C; Wiseman R W; Berchuck A; Iglehart J D; Marks J R; Ashworth A; Stratton M R; Futreal P A
BRCA2 mutations in primary breast and ovarian cancers.
Nature genetics 1996;13(2):238-40.
1996: Theodosiou A M; Rodrigues N R; Nesbit M A; Ambrose H J; Paterson H; McLellan-Arnold E; Boyd Y; Leversha M A; Owen N; Blake D J; Ashworth A; Davies K E
A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region.
Human molecular genetics 1996;5(5):675-84.
1996: Heard E; Kress C; Mongelard F; Courtier B; Rougeulle C; Ashworth A; Vourc'h C; Babinet C; Avner P
Transgenic mice carrying an Xist-containing YAC.
Human molecular genetics 1996;5(4):441-50.
1996: Kipling D; Wilson H E; Thomson E J; Lee M; Perry J; Palmer S; Ashworth A; Cooke H J
Structural variation of the pseudoautosomal region between and within inbred mouse strains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):171-5.
1995: King A G; Ozanne B W; Smythe C; Ashworth A
Isolation and characterisation of a uniquely regulated threonine, tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk.
Oncogene 1995;11(12):2553-63.
1995: Herzing L B; Ashworth A
Construction of specific cosmids from YACs by homologous recombination in yeast.
Nucleic acids research 1995;23(19):4005-6.
1995: Denny P; Ashworth A
Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7.
Mammalian genome : official journal of the International Mammalian Genome Society 1995;6(9):683.
1995: Olson M F; Ashworth A; Hall A
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1.
Science (New York, N.Y.) 1995;269(5228):1270-2.
1995: Connor F; Wright E; Denny P; Koopman P; Ashworth A
The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse.
Nucleic acids research 1995;23(17):3365-72.
1995: Macaulay V M; Bates P J; McLean M J; Rowlands M G; Jenkins T C; Ashworth A; Neidle S
Inhibition of aromatase expression by a psoralen-linked triplex-forming oligonucleotide targeted to a coding sequence.
FEBS letters 1995;372(2-3):222-8.
1995: Palmer S; Perry J; Ashworth A
A contravention of Ohno's law in mice.
Nature genetics 1995;10(4):472-6.
1995: Swift S; Ashworth A
The mouse Ftzf1 gene required for gonadal and adrenal development maps to mouse chromosome 2.
Genomics 1995;28(3):609-10.
1995: Lee K; Macaulay V M; Nicholls J E; Detre S; Ashworth A; Dowsett M
An in vivo model of intratumoural aromatase using aromatase-transfected MCF7 human breast cancer cells.
International journal of cancer. Journal international du cancer 1995;62(3):297-302.
1995: Horn J M; Ashworth A
A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes.
Human molecular genetics 1995;4(6):1041-7.
1995: Taylor-Harris P; Swift S; Ashworth A
Zfyl encodes a nuclear sequence-specific DNA binding protein.
FEBS letters 1995;360(3):315-9.
1995: Alessi D R; Cohen P; Ashworth A; Cowley S; Leevers S J; Marshall C J
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Methods in enzymology 1995;255():279-90.
1994: Denny P; Ashworth A
Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(10):643-5.
1994: Connor F; Cary P D; Read C M; Preston N S; Driscoll P C; Denny P; Crane-Robinson C; Ashworth A
DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5.
Nucleic acids research 1994;22(16):3339-46.
1994: Ashworth A; Malik A N; Walkley N A; Kubota H; Willison K R
The Tcp-1-related gene, Cctg, maps to mouse chromosome 3.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(8):509-10.
1994: Alessi D R; Saito Y; Campbell D G; Cohen P; Sithanandam G; Rapp U; Ashworth A; Marshall C J; Cowley S
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
The EMBO journal 1994;13(7):1610-9.
1994: Saito Y; Gomez N; Campbell D G; Ashworth A; Marshall C J; Cohen P
The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells.
FEBS letters 1994;341(1):119-24.
1994: Kubota H; Hynes G; Carne A; Ashworth A; Willison K
Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin.
Current biology : CB 1994;4(2):89-99.
1994: Macaulay V M; Nicholls J E; Gledhill J; Rowlands M G; Dowsett M; Ashworth A
Biological effects of stable overexpression of aromatase in human hormone-dependent breast cancer cells.
British journal of cancer 1994;69(1):77-83.
1993: Ashworth A
Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes.
Genomics 1993;18(2):195-8.
1993: Hughes D A; Ashworth A; Marshall C J
Complementation of byr1 in fission yeast by mammalian MAP kinase kinase requires coexpression of Raf kinase.
Nature 1993;364(6435):349-52.
1993: Dowsett M; Macaulay V; Gledhill J; Ryde C; Nicholls J; Ashworth A; McKinna J A; Smith I E
Control of aromatase in breast cancer cells and its importance for tumor growth.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):605-9.
1993: Bedford F K; Ashworth A; Enver T; Wiedemann L M
HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human.
Nucleic acids research 1993;21(5):1245-9.
1993: Goldsborough A S; Healy L E; Copeland N G; Gilbert D J; Jenkins N A; Willison K R; Ashworth A
Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11.
Nucleic acids research 1993;21(1):127-34.
1993: Kay G F; Penny G D; Patel D; Ashworth A; Brockdorff N; Rastan S
Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation.
Cell 1993;72(2):171-82.
1992: Ashworth A; Nakielny S; Cohen P; Marshall C
The amino acid sequence of a mammalian MAP kinase kinase.
Oncogene 1992;7(12):2555-6.
1992: Connor F; Ashworth A
Sequence of cDNA for Xenopus XZFY-1.
Nucleic acids research 1992;20(21):5845.
1992: Brockdorff N; Ashworth A; Kay G F; McCabe V M; Norris D P; Cooper P J; Swift S; Rastan S
The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.
Cell 1992;71(3):515-26.
1992: Denny P; Swift S; Connor F; Ashworth A
An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein.
The EMBO journal 1992;11(10):3705-12.
1992: Kubota H; Willison K; Ashworth A; Nozaki M; Miyamoto H; Yamamoto H; Matsushiro A; Morita T
Structure and expression of the gene encoding mouse t-complex polypeptide (Tcp-1).
Gene 1992;120(2):207-15.
1992: Denny P; Swift S; Brand N; Dabhade N; Barton P; Ashworth A
A conserved family of genes related to the testis determining gene, SRY.
Nucleic acids research 1992;20(11):2887.
1991: Kay G F; Ashworth A; Penny G D; Dunlop M; Swift S; Brockdorff N; Rastan S
A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1.
Nature 1991;354(6353):486-9.
1991: Denny P; Ashworth A
A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis.
Gene 1991;106(2):221-7.
1991: Ashworth A; Rastan S; Lovell-Badge R; Kay G
X-chromosome inactivation may explain the difference in viability of XO humans and mice.
Nature 1991;351(6325):406-8.
1991: Brockdorff N; Ashworth A; Kay G F; Cooper P; Smith S; McCabe V M; Norris D P; Penny G D; Patel D; Rastan S
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.
Nature 1991;351(6324):329-31.
1991: Koopman P; Ashworth A; Lovell-Badge R
The ZFY gene family in humans and mice.
Trends in genetics : TIG 1991;7(4):132-6.
1991: Ashworth A; Denny P
Zinc finger protein genes in the mouse genome.
Mammalian genome : official journal of the International Mammalian Genome Society 1991;1(3):196-200.
1990: Ashworth A; Kraft A
Cloning of a potentially soluble receptor for human GM-CSF.
Nucleic acids research 1990;18(23):7178.
1990: Ashworth A; Skene B; Swift S; Lovell-Badge R
Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.
The EMBO journal 1990;9(5):1529-34.
1990: Goldsborough A; Ashworth A; Willison K
Cloning and sequencing of POU-boxes expressed in mouse testis.
Nucleic acids research 1990;18(6):1634.
1989: Shephard E A; Phillips I R; Santisteban I; West L F; Palmer C N; Ashworth A; Povey S
Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2.
Annals of human genetics 1989;53(Pt 4):291-301.
1989: Ashworth A; Williams B P; Buchberg A M; Goodfellow P N; Solomon E; Potter J; Willison K R
Chromosomal localization of zinc finger protein genes in man and mouse.
Genomics 1989;4(3):323-7.
1989: Ashworth A; Swift S; Affara N
Sequence of cDNA for murine Zfy-1, a candidate for Tdy.
Nucleic acids research 1989;17(7):2864.
1987: Shephard E A; Phillips I R; Ashworth A; Ferrie J S; Forrest L A; Bell D R; Thompson S; Austin C A
Structure and expression of genes coding for components of the cytochrome P-450-mediated mono-oxygenase.
Biochemical Society transactions 1987;15(4):573-5.
1986: Ashworth A; Shephard E A; Phillips I R
Disease-gene relationship seen.
Nature 1986;322(6080):599.
1985: Phillips I R; Shephard E A; Ashworth A; Rabin B R
Isolation and sequence of a human cytochrome P-450 cDNA clone.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(4):983-7.
1984: Phillips I R; Shephard E A; Ashworth A
Cloning of cDNA coding for a rat liver protein whose expression is subject to gender-specific regulation by xenobiotics.
Biochemical Society transactions 1984;12(1):103-4.
1983: Phillips I R; Shephard E A; Ashworth A; Rabin B R
Cloning and sequence analysis of a rat liver cDNA coding for a phenobarbital-inducible microheterogenous cytochrome P-450 variant: regulation of its messenger level by xenobiotics.
Gene 1983;26(1):41-52.
1983: Phillips I R; Shephard E A; Rabin B R; Bayney R M; Pike S F; Ashworth A; Estall M R
Factors controlling the expression of genes coding for drug-metabolizing enzymes.
Biochemical Society transactions 1983;11(4):460-3.
1982: Shephard E A; Phillips I R; Pike S F; Ashworth A; Rabin B R
Differential effect of phenobarbital and beta-naphthoflavone on the mRNAs coding for cytochrome P450 and NADPH cytochrome P450 reductase.
FEBS letters 1982;150(2):375-80.

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