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Dorothea Torous

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Souk Phonethepswath; Dorothea K Torous; Svetlana L Avlasevich; Jeffrey Bemis; James T Macgregor; Jared Mereness; Stephen D Dertinger
Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice.
Matthew J LeBaron; Melissa R Schisler; Dorothea K Torous; Stephen D Dertinger; B Bhaskar Gollapudi
Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test.
Stephen D Dertinger; Svetlana L Avlasevich; Sara Bell; Jeffrey Bemis; Steven M Bryce; Jared Mereness; Souk Phonethepswath; Dorothea K Torous; Pamela Weller; James T Macgregor
Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.

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2013: Souk Phonethepswath; Dorothea K Torous; Svetlana L Avlasevich; Jeffrey Bemis; James T Macgregor; Jared Mereness; Stephen D Dertinger
Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice.
Environmental and molecular mutagenesis 2013;54(4):294-8.
2013: Matthew J LeBaron; Melissa R Schisler; Dorothea K Torous; Stephen D Dertinger; B Bhaskar Gollapudi
Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test.
Environmental and molecular mutagenesis 2013;54(3):222-8.
2012: Stephen D Dertinger; Svetlana L Avlasevich; Sara Bell; Jeffrey Bemis; Steven M Bryce; Jared Mereness; Souk Phonethepswath; Dorothea K Torous; Pamela Weller; James T Macgregor
Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.
Toxicological sciences : an official journal of the Society of Toxicology 2012;130(2):328-48.
2012: Jeffrey Bemis; Stephen D Dertinger; Dorothea K Torous
Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.
Research report (Health Effects Institute) 2012;(166):125-57.
2012: Dorothea K Torous; Pamela Weller; Svetlana L Avlasevich; Sara Bell; Jeffrey Bemis; Steven M Bryce; Laura L Custer; Carol Gleason; James T MacGregor; Jared Mereness; Souk Phonethepswath; Stephen D Dertinger
In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.
Environmental and molecular mutagenesis 2012;53(6):420-8.
2011: Stephen D Dertinger; Svetlana L Avlasevich; Michael Aylott; Sara Bell; Jeffrey Bemis; Steven M Bryce; Jared A Mereness; Souk Phonethepswath; Susan Portugal; Dorothea K Torous; Pamela Weller; James T MacGregor
Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.
Environmental and molecular mutagenesis 2011;52(9):748-55.
2011: Christine L Lemieux; David H Phillips; Souk Phonethepswath; Dorothea K Torous; Volker M Arlt; Stephen D Dertinger; George R Douglas; John Gingerich; Paul A White
Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse.
Environmental and molecular mutagenesis 2011;52(9):756-65.
2011: Stephen D Dertinger; Dorothea K Torous; Makoto Hayashi; James T MacGregor
Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage.
Mutagenesis 2011;26(1):139-45.
2010: Stephen D Dertinger; Souk Phonethepswath; Dean Franklin; Pamela Weller; Dorothea K Torous; Steven M Bryce; Svetlana Avlasevich; Jeffrey Bemis; Ollivier Hyrien; James Palis; James T MacGregor
Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(2):401-11.
2010: Souk Phonethepswath; Dean Franklin; Dorothea K Torous; Steven M Bryce; Jeffrey Bemis; Sarojini Raja; Svetlana Avlasevich; Pamela Weller; Ollivier Hyrien; James Palis; James T Macgregor; Stephen D Dertinger
Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(1):59-70.
2009: Julie P Goff; Donna S Shields; Mineaki Seki; Serah Choi; Michael W Epperly; Tracy Dixon; Hong Wang; Christopher J Bakkenist; Stephen D Dertinger; Dorothea K Torous; John Wittschieben; Richard D Wood; Joel S Greenberger
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
Radiation research 2009;172(2):165-74.
2008: Jeffrey C Bemis; Dorothea K Torous; Carol R Tometsko; Stephen D Dertinger
Cross-species genetic toxicity assessment accomplished by flow cytometric analysis of blood.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2008;Chapter 2():Unit2.14.
2008: Kristine L Witt; Elizabeth Livanos; Grace E Kissling; Dorothea K Torous; William Caspary; Raymond R Tice; Leslie Recio
Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals.
Mutation research 2008;649(1-2):101-13.
2007: Stephen D Dertinger; Ying Tsai; Irena Nowak; Ollivier Hyrien; Hongliang Sun; Jeffrey Bemis; Dorothea K Torous; Peter Keng; James Palis; Yuhchyau Chen
Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry.
Mutation research 2007;634(1-2):119-25.
2007: Stephen D Dertinger; Richard Miller; Kelly Brewer; Therese Smudzin; Dorothea K Torous; Daniel J Roberts; Svetlana L Avlasevich; Steven M Bryce; Siva Sugunan; Yuhchyau Chen
Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage.
Mutation research 2007;626(1-2):111-9.
2006: Stephen D Dertinger; Michelle E Bishop; James P McNamee; Makoto Hayashi; Takayoshi Suzuki; Norihide Asano; Madoka Nakajima; Junichiro Saito; Martha Moore; Dorothea K Torous; James T MacGregor
Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(1):83-91.
2006: Norihide Asano; Dorothea K Torous; Carol R Tometsko; Stephen D Dertinger; Takeshi Morita; Makoto Hayashi
Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine.
Mutagenesis 2006;21(1):15-20.
2006: Dorothea K Torous; Norihide Asano; Carol Tometsko; Siva Sugunan; Stephen D Dertinger; Takeshi Morita; Makoto Hayashi
Performance of flow cytometric analysis for the micronucleus assay--a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood.
Mutagenesis 2006;21(1):11-3.
2005: Dorothea K Torous; Nikki E Hall; Anne H Illi-Love; Marilyn S Diehl; Karin Cederbrant; Kerstin Sandelin; Ingrid Pontén; George Bolcsfoldi; Lynnette Ferguson; Amira Pearson; Jenness B Majeska; James P Tarca; Geoffrey M Hynes; Anthony Lynch; James P McNamee; Pascale V Bellier; Monique Parenteau; David Blakey; Janet Bayley; Bas-Jan M van der Leede; Philippe Vanparys; Philip R Harbach; Shuou Zhao; Anthony L Filipunas; Carol W Johnson; Carol R Tometsko; Stephen D Dertinger
Interlaboratory validation of a CD71-based flow cytometric method (Microflow) for the scoring of micronucleated reticulocytes in mouse peripheral blood.
Environmental and molecular mutagenesis 2005;45(1):44-55.
2004: Stephen D Dertinger; Kevin A Camphausen; James T MacGregor; Michelle E Bishop; Dorothea K Torous; Svetlana L Avlasevich; Siân Cairns; Carol R Tometsko; Cynthia Menard; Thierry Muanza; Yuhchyau Chen; Richard Miller; Karin Cederbrant; Kerstin Sandelin; Ingrid Pontén; George Bolcsfoldi
Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.
Environmental and molecular mutagenesis 2004;44(5):427-35.
2003: Stephen D Dertinger; Yuhchyau Chen; Richard Miller; Kelly J Brewer; Therese Smudzin; Dorothea K Torous; Nikki E Hall; Kristine A Olvany; Francis G Murante; Carol R Tometsko
Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans.
Mutation research 2003;542(1-2):77-87.
2003: Dorothea K Torous; Nikki E Hall; Francis G Murante; Sarah E Gleason; Carol R Tometsko; Stephen D Dertinger
Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):309-14.
2002: Stephen D Dertinger; Dorothea K Torous; Nikki E Hall; Francis G Murante; Sarah E Gleason; Richard Miller; Carol R Tometsko
Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer.
Mutation research 2002;515(1-2):3-14.
2002: G M Hynes; Dorothea K Torous; Carol R Tometsko; B Burlinson; D G Gatehouse
The single laser flow cytometric micronucleus test: a time course study using colchicine and urethane in rat and mouse peripheral blood and acetaldehyde in rat peripheral blood.
Mutagenesis 2002;17(1):15-23.
2001: LN Healy; Linda Pluta; R Arden James; Derek B Janszen; Dorothea K Torous; John E French; Leslie Recio
Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53+/- mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation.
Mutagenesis 2001;16(2):163-8.
2000: Dorothea K Torous; Stephen D Dertinger; Nikki E Hall; Carol R Tometsko
Enumeration of micronucleated reticulocytes in rat peripheral blood: a flow cytometric study.
Mutation research 2000;465(1-2):91-9.
2000: Stephen D Dertinger; Dorothea K Torous; Nikki E Hall; Carol R Tometsko; Thomas A Gasiewicz
Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry.
Mutation research 2000;464(2):195-200.
1998: Dorothea K Torous; Stephen D Dertinger; Nikki E Hall; Carol R Tometsko
An automated method for discriminating aneugen- vs. clastogen-induced micronuclei.
Environmental and molecular mutagenesis 1998;31(4):340-4.
1997: Stephen D Dertinger; Dorothea K Torous; K R Tometsko
Flow cytometric analysis of micronucleated reticulocytes in mouse bone marrow.
Mutation research 1997;390(3):257-62.
1996: Stephen D Dertinger; Dorothea K Torous; K R Tometsko
Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer.
Mutation research 1996;371(3-4):283-92.
1996: Stephen D Dertinger; Dorothea K Torous; K R Tometsko
Induction of micronuclei by low doses of azidothymidine (AZT).
Mutation research 1996;368(3-4):301-7.
1995: Stephen D Dertinger; Dorothea K Torous; A M Tometsko
Modulation of phorbol ester-induced HL-60 differentiation by prostaglandin E2.
Mutation research 1995;328(1):55-62.
1995: A M Tometsko; Stephen D Dertinger; Dorothea K Torous
Analysis of micronucleated cells by flow cytometry. 4. Kinetic analysis of cytogenetic damage in blood.
Mutation research 1995;334(1):9-18.
1995: Stephen D Dertinger; Dorothea K Torous; A M Tometsko
Development of a sensitive in vitro method for identifying tumor promoters.
Mutation research 1995;334(1):49-57.
1993: A M Tometsko; Dorothea K Torous; Stephen D Dertinger
Analysis of micronucleated cells by flow cytometry. 3. Advanced technology for detecting clastogenic activity.
Mutation research 1993;292(2):145-53.
1993: A M Tometsko; Stephen D Dertinger; Dorothea K Torous
Analysis of micronucleated cells by flow cytometry. 2. Evaluating the accuracy of high-speed scoring.
Mutation research 1993;292(2):137-43.
1993: A M Tometsko; Dorothea K Torous; Stephen D Dertinger
Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model.
Mutation research 1993;292(2):129-35.
1993: Stephen D Dertinger; Dorothea K Torous; A M Tometsko
In vitro system for detecting non-genotoxic carcinogens.
Environmental and molecular mutagenesis 1993;21(4):332-8.