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Alan Thomas

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F H A Osier; Gareth D Weedall; Federica Verra; Linda Murungi; Kevin K A Tetteh; Peter C Bull; Bart W Faber; Ed Remarque; Alan Thomas; Kevin Marsh; David J Conway
Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya.
Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Pascale Cheront; Doriano Cingolani; Florence Xhonneux; Margarita Jurado; Michele Haumont; Soren Jepsen; Odile Leroy; Alan Thomas
Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris.
Edmond J Remarque; Bart W Faber; Clemens H M Kocken; Alan Thomas
A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits.

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All Publications

2010: F H A Osier; Gareth D Weedall; Federica Verra; Linda Murungi; Kevin K A Tetteh; Peter C Bull; Bart W Faber; Ed Remarque; Alan Thomas; Kevin Marsh; David J Conway
Allelic diversity and naturally acquired allele-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 in Kenya.
Infection and immunity 2010;78(11):4625-33.
2008: Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Pascale Cheront; Doriano Cingolani; Florence Xhonneux; Margarita Jurado; Michele Haumont; Soren Jepsen; Odile Leroy; Alan Thomas
Production, quality control, stability and pharmacotoxicity of cGMP-produced Plasmodium falciparum AMA1 FVO strain ectodomain expressed in Pichia pastoris.
Vaccine 2008;26(48):6143-50.
2008: Edmond J Remarque; Bart W Faber; Clemens H M Kocken; Alan Thomas
A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits.
Infection and immunity 2008;76(6):2660-70.
2008: F H A Osier; Greg Fegan; Spencer D Polley; Linda Murungi; Federica Verra; Kevin K A Tetteh; Brett Lowe; Tabitha Mwangi; Peter C Bull; Alan Thomas; David Cavanagh; Jana S McBride; David Lanar; Margaret J Mackinnon; David J Conway; Kevin Marsh
Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria.
Infection and immunity 2008;76(5):2240-8.
2008: Annemarie Voorberg-vd Wel; Clemens H M Kocken; Anne-Marie Zeeman; Alan Thomas
Detection of new Babesia microti-like parasites in a rhesus monkey (Macaca mulatta) with a suppressed Plasmodium cynomolgi infection.
The American journal of tropical medicine and hygiene 2008;78(4):643-5.
2008: Edmond J Remarque; Bart W Faber; Clemens H M Kocken; Alan Thomas
Apical membrane antigen 1: a malaria vaccine candidate in review.
Trends in parasitology 2008;24(2):74-84.
2008: R Alan Wilson; Jan A M Langermans; Govert van Dam; Richard Vervenne; Stephanie L Hall; William C Borges; Gary P Dillon; Alan Thomas; Patricia S Coulson
Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?
PLoS neglected tropical diseases 2008;2(9):e290.
2007: Bart W Faber; Edmond J Remarque; William D Morgan; Clemens H M Kocken; Anthony A Holder; Alan Thomas
Malaria vaccine-related benefits of a single protein comprising Plasmodium falciparum apical membrane antigen 1 domains I and II fused to a modified form of the 19-kilodalton C-terminal fragment of merozoite surface protein 1.
Infection and immunity 2007;75(12):5947-55.
2007: Allan Saul; Meike Hensmann; Jetsumon Sattabongkot; W E Collins; John W Barnwell; Jan A M Langermans; Yimin Wu; Carole A Long; Filip Dubovsky; Alan Thomas
Immunogenicity in rhesus of the Plasmodium vivax mosquito stage antigen Pvs25H with Alhydrogel and Montanide ISA 720.
Parasite immunology 2007;29(10):525-33.
2007: Sébastien Igonet; Brigitte Vulliez-Le Normand; Grazyna FAURE; Marie-Madeleine Riottot; Clemens H M Kocken; Alan Thomas; Graham A Bentley
Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation.
Journal of molecular biology 2007;366(5):1523-37.
2007: Christine R Collins; Chrislaine Withers-Martinez; Graham A Bentley; Adrian H Batchelor; Alan Thomas; Michael J Blackman
Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.
The Journal of biological chemistry 2007;282(10):7431-41.
2007: Gareth D Weedall; Benjamin M J Preston; Alan Thomas; Colin J Sutherland; David J Conway
Differential evidence of natural selection on two leading sporozoite stage malaria vaccine candidate antigens.
International journal for parasitology 2007;37(1):77-85.
2006: Federica Verra; Spencer D Polley; Alan Thomas; David J Conway
Comparative analysis of molecular variation in Plasmodium falciparum and P. reichenowi maebl gene.
Parassitologia 2006;48(4):567-72.
2006: Jan A M Langermans; Meike Hensmann; Marcel van Gijlswiik; Dongmei Zhang; Weiqing Pan; Birgitte K Giersing; Emily Locke; Filip Dubovsk; Janet Wittes; Alan Thomas
Preclinical evaluation of a chimeric malaria vaccine candidate in Montanide ISA 720: immunogenicity and safety in rhesus macaques.
Human vaccines 2006;2(5):222-6.
2006: Erica M Pasini; Morten Kirkegaard; Peter Mortensen; Hans U Lutz; Alan Thomas; Matthias Mann
In-depth analysis of the membrane and cytosolic proteome of red blood cells.
Blood 2006;108(3):791-801.
2006: Clemens H M Kocken; Annemarie van der Wel; Sarah Arbe-Barnes; Reto Brun; Hugues Matile; Christian Scheurer; Sergio Wittlin; Alan Thomas
Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.
Experimental parasitology 2006;113(3):197-200.
2006: Thilan Wickramarachchi; Prasad H Premaratne; K L R Lakshman Perera; Sumith Bandara; Clemens H M Kocken; Alan Thomas; Shiroma M Handunnetti; Preethi V Udagama-Randeniya
Natural human antibody responses to Plasmodium vivax apical membrane antigen 1 under low transmission and unstable malaria conditions in Sri Lanka.
Infection and immunity 2006;74(1):798-801.
2005: Marie-Laure Chesne-seck; Juan Carlos Pizarro; Brigitte Vulliez-Le Normand; Christine R Collins; Michael J Blackman; Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Alan Thomas; Graham A Bentley
Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasites.
Molecular and biochemical parasitology 2005;144(1):55-67.
2005: Jan A M Langermans; Annette Schmidt; Richard Vervenne; Ashley Birkett; J Mauricio Calvo-Calle; Meike Hensmann; george thornton; Filip Dubovsky; Horst Weiler; Elizabeth H Nardin; Alan Thomas
Effect of adjuvant on reactogenicity and long-term immunogenicity of the malaria Vaccine ICC-1132 in macaques.
Vaccine 2005;23(41):4935-43.
2005: Spencer D Polley; Gareth D Weedall; Alan Thomas; Linnie M Golightly; David J Conway
Orthologous gene sequences of merozoite surface protein 1 (MSP1) from Plasmodium reichenowi and P. gallinaceum confirm an ancient divergence of P. falciparum alleles.
Molecular and biochemical parasitology 2005;142(1):25-31.
2005: Jan A M Langermans; T Mark Doherty; Richard Vervenne; Tridia Van der Laan; Konstantin P Lyashchenko; Rena Greenwald; Else Marie Agger; Claus Aagaard; Horst Weiler; Dick Van Soolingen; Wilfried Dalemans; Alan Thomas; Peter Andersen
Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.
Vaccine 2005;23(21):2740-50.
2005: Juan Carlos Pizarro; Brigitte Vulliez-Le Normand; Marie-Laure Chesne-seck; Christine R Collins; Chrislaine Withers-Martinez; Fiona Hackett; Michael J Blackman; Bart W Faber; Edmond J Remarque; Clemens H M Kocken; Alan Thomas; Graham A Bentley
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.
Science (New York, N.Y.) 2005;308(5720):408-11.
2005: Sheetij Dutta; J David Haynes; Arnoldo Barbosa; Lisa A Ware; Jeffrey D Snavely; J Kathleen Moch; Alan Thomas; David Lanar
Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum.
Infection and immunity 2005;73(4):2116-22.
2005: Agam P Singh; Hastings Ozwara; Clemens H M Kocken; SUNIL KUMAR PURI; Alan Thomas; Chetan E Chitnis
Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion.
Molecular microbiology 2005;55(6):1925-34.
2005: Maria Helena C Rodrigues; Karina M Rodrigues; Tatiane R Oliveira; Andréia N Cômodo; Mauricio M Rodrigues; Clemens H M Kocken; Alan Thomas; Irene S Soares
Antibody response of naturally infected individuals to recombinant Plasmodium vivax apical membrane antigen-1.
International journal for parasitology 2005;35(2):185-92.
2004: Spencer D Polley; Tabitha W Mwangi; Clemens H M Kocken; Alan Thomas; Sheetij Dutta; David Lanar; Edmond J Remarque; Amanda Ross; Thomas N Williams; Gabrielle Mwambingu; Brett Lowe; David J Conway; Kevin Marsh
Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malaria.
Vaccine 2004;23(5):718-28.
2004: Brigitte Vulliez-Le Normand; Juan Carlos Pizarro; Marie-Laure Chesne-seck; Clemens H M Kocken; Bart W Faber; Alan Thomas; Graham A Bentley
Expression, crystallization and preliminary structural analysis of the ectoplasmic region of apical membrane antigen 1 from Plasmodium vivax, a malaria-vaccine candidate.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 11):2040-3.
2004: Casilda G Black; Lina Wang; Agnieszka E Topolska; David Finkelstein; Malcolm K Horne; Alan Thomas; Narla Mohandas; Ross Coppel
Merozoite surface proteins 4 and 5 of Plasmodium knowlesi have differing cellular localisation and association with lipid rafts.
Molecular and biochemical parasitology 2004;138(1):153-8.
2004: Johannes J P M Bogers; Shyama Chatterjee; Werner Jacobs; Padraic G Fallon; David W Dunne; Jan A M Langermans; André M Deelder; Alan Thomas; Eric A Van Marck
Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni.
Virchows Archiv : an international journal of pathology 2004;445(3):285-91.
2004: Lbachir BenMohamed; Alan Thomas; Pierre Druilhe
Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides.
Infection and immunity 2004;72(8):4376-84.
2004: Richard Vervenne; Stephen L Jones; Dick Van Soolingen; Tridia Van der Laan; Peter Andersen; Peter J Heidt; Alan Thomas; Jan A M Langermans
TB diagnosis in non-human primates: comparison of two interferon-gamma assays and the skin test for identification of Mycobacterium tuberculosis infection.
Veterinary immunology and immunopathology 2004;100(1-2):61-71.
2004: Patrick Verloo; Clemens H M Kocken; Annemarie van der Wel; Ben C Tilly; Boris M Hogema; Maarten Sinaasappel; Alan Thomas; Hugo R de Jonge
Plasmodium falciparum-activated chloride channels are defective in erythrocytes from cystic fibrosis patients.
The Journal of biological chemistry 2004;279(11):10316-22.
2004: Olivier Silvie; Jean-François Franetich; Stéphanie Charrin; Markus S Mueller; Anthony Siau; Myriam Bodescot; Eric Rubinstein; Laurent Hannoun; Yupin Charoenvit; Clemens H M Kocken; Alan Thomas; Geert-Jan van Gemert; Robert W Sauerwein; Michael J Blackman; Robin F Anders; Gerd Pluschke; Dominique Mazier
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites.
The Journal of biological chemistry 2004;279(10):9490-6.
2004: Annemarie v d Wel; Clemens H M Kocken; Tamarah C Pronk; Blandine Franke-Fayard; Alan Thomas
New selectable markers and single crossover integration for the highly versatile Plasmodium knowlesi transfection system.
Molecular and biochemical parasitology 2004;134(1):97-104.
2004: Joanne L Casey; Andrew M Coley; Robin F Anders; Vince J Murphy; Karen S Humberstone; Alan Thomas; Michael Foley
Antibodies to malaria peptide mimics inhibit Plasmodium falciparum invasion of erythrocytes.
Infection and immunity 2004;72(2):1126-34.
2004: Graham H Mitchell; Alan Thomas; Gabriele Margos; Anton R Dluzewski; Lawrence H Bannister
Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells.
Infection and immunity 2004;72(1):154-8.
2003: Alexandra Van Remoortere; HJ Vermeer; Anne-Marie M van Roon; Jan A M Langermans; Alan Thomas; R Alan Wilson; Irma Van Die; DH van den Eijnden; Károly Agoston; J Kérèkgyarto; Johannes Vliegenthart; Johannis P Kamerling; Govert van Dam; Cornelis H Hokke; André M Deelder
Dominant antibody responses to Fucalpha1-3GalNAc and Fucalpha1-2Fucalpha1-3GlcNAc containing carbohydrate epitopes in Pan troglodytes vaccinated and infected with Schistosoma mansoni.
Experimental parasitology 2003;105(3-4):219-25.
2003: Lawrence H Bannister; John M Hopkins; Anton R Dluzewski; Gabriele Margos; Ian T Williams; Michael J Blackman; Clemens H M Kocken; Alan Thomas; Graham H Mitchell
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite development.
Journal of cell science 2003;116(Pt 18):3825-34.
2003: Hastings Ozwara; Annemarie van der Wel; Clemens H M Kocken; Alan Thomas
Heterologous promoter activity in stable and transient Plasmodium knowlesi transgenes.
Molecular and biochemical parasitology 2003;130(1):61-4.
2003: Hastings Ozwara; Jan A M Langermans; Jenneby Maamun; Idle O Farah; Dorcas S Yole; Jason M Mwenda; Horst Weiler; Alan Thomas
Experimental infection of the olive baboon (Paplio anubis) with Plasmodium knowlesi: severe disease accompanied by cerebral involvement.
The American journal of tropical medicine and hygiene 2003;69(2):188-94.
2003: Hastings Ozwara; Jan A M Langermans; Clemens H M Kocken; Annemarie van der Wel; Peter H van der Meide; Richard Vervenne; Jason M Mwenda; Alan Thomas
Transfected Plasmodium knowlesi produces bioactive host gamma interferon: a new perspective for modulating immune responses to malaria parasites.
Infection and immunity 2003;71(8):4375-81.
2003: Jake Baum; Alan Thomas; David J Conway
Evidence for diversifying selection on erythrocyte-binding antigens of Plasmodium falciparum and P. vivax.
Genetics 2003;163(4):1327-36.
2003: Padraic G Fallon; Jason Gibbons; Richard Vervenne; Emma J Richardson; Anthony J C Fulford; Simon Kiarie; Robert F Sturrock; Patricia S Coulson; André M Deelder; Jan A M Langermans; Alan Thomas; David W Dunne
Juvenile rhesus monkeys have lower type 2 cytokine responses than adults after primary infection with Schistosoma mansoni.
The Journal of infectious diseases 2003;187(6):939-45.
2002: Thierry Joët; Lennart Holterman; T Stedman; Clemens H M Kocken; Annemarie van der Wel; Alan Thomas; Sanjeev Krishna
Comparative characterization of hexose transporters of Plasmodium knowlesi, Plasmodium yoelii and Toxoplasma gondii highlights functional differences within the apicomplexan family.
The Biochemical journal 2002;368(Pt 3):923-9.
2002: Clemens H M Kocken; Chrislaine Withers-Martinez; Martin A Dubbeld; Annemarie van der Wel; Fiona Hackett; Augusto Valderrama; Michael J Blackman; Alan Thomas
High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.
Infection and immunity 2002;70(8):4471-6.
2002: Matthias Eberl; Maged M Al-Sherbiny; Paul Hagan; Srdjan Ljubojevic; Alan Thomas; R Alan Wilson
A novel and sensitive method to monitor helminth infections by faecal sampling.
Acta tropica 2002;83(2):183-7.
2002: Kai Wengelnik; Valerie Vidal; Marie Laure Ancelin; Anne-Marie Cathiard; Jean Louis Morgat; Clemens H M Kocken; Michèle Calas; Socrates Herrera; Alan Thomas; Henri VIAL
A class of potent antimalarials and their specific accumulation in infected erythrocytes.
Science (New York, N.Y.) 2002;295(5558):1311-4.
2002: Clemens H M Kocken; Hastings Ozwara; Annemarie van der Wel; Annette L Beetsma; Jason M Mwenda; Alan Thomas
Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studies.
Infection and immunity 2002;70(2):655-60.
2001: Jan A M Langermans; Peter Andersen; Dick Van Soolingen; Richard Vervenne; patrice frost; Tridia Van der Laan; L A van Pinxteren; J van den Hombergh; S Kroon; I Peekel; S Florquin; Alan Thomas
Divergent effect of bacillus Calmette-Guérin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: implications for primate models in tuberculosis vaccine research.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11497-502.
2001: Jörg Schneider; J A Langermans; Sarah Gilbert; Tom J Blanchard; S Twigg; S Naitza; Carolyn M Hannan; M Aidoo; Andrea Crisanti; Kathryn J H Robson; Geoffrey L Smith; Adrian V S Hill; Alan Thomas
A prime-boost immunisation regimen using DNA followed by recombinant modified vaccinia virus Ankara induces strong cellular immune responses against the Plasmodium falciparum TRAP antigen in chimpanzees.
Vaccine 2001;19(32):4595-602.
2001: Matthias Eberl; Jan A M Langermans; patrice frost; Richard Vervenne; Govert van Dam; André M Deelder; Alan Thomas; Patricia S Coulson; R Alan Wilson
Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees.
Infection and immunity 2001;69(9):5352-62.
2001: Steven A Howell; Chrislaine Withers-Martinez; Clemens H M Kocken; Alan Thomas; Michael J Blackman
Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.
The Journal of biological chemistry 2001;276(33):31311-20.
2001: Hastings Ozwara; Clemens H M Kocken; David J Conway; Jason M Mwenda; Alan Thomas
Comparative analysis of Plasmodium reichenowi and P. falciparum erythrocyte-binding proteins reveals selection to maintain polymorphism in the erythrocyte-binding region of EBA-175.
Molecular and biochemical parasitology 2001;116(1):81-4.
2001: Michael Theisen; Alan Thomas; S Jepsen
Cloning, nucleotide sequencing and analysis of the gene encoding the glutamate-rich protein (GLURP) from Plasmodium reichenowi.
Molecular and biochemical parasitology 2001;115(2):269-73.
2001: Matthias Eberl; Jan A M Langermans; Richard Vervenne; A Kwame Nyame; Richard D Cummings; Alan Thomas; Patricia S Coulson; R Alan Wilson
Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?
The Journal of infectious diseases 2001;183(8):1238-47.
2000: Jan A M Langermans; Richard Vervenne; J Hersbach; Alan Thomas
Reactivity of human T-lymphocyte-specific antibodies with peripheral blood mononuclear cells and spleen of Aotus azarae ssp. boliviensis (owl monkey).
Journal of medical primatology 2000;29(6):397-401.
2000: David J Conway; Caterina Fanello; Jennifer M Lloyd; B M Al-Joubori; A H Baloch; S D Somanath; Cally Roper; Ayoade Oduola; B Mulder; Marinete M Povoa; B Singh; Alan Thomas
Origin of Plasmodium falciparum malaria is traced by mitochondrial DNA.
Molecular and biochemical parasitology 2000;111(1):163-71.
2000: P Daubersies; Alan Thomas; P Millet; Karima Brahimi; J A Langermans; Benjamin Ollomo; Lbachir BenMohamed; B Slierendregt; Wijnand Eling; Alex Van Belkum; G Dubreuil; Jacques Meis; Claudine Guérin-Marchand; S Cayphas; J Cohen; Hélène Gras-Masse; Pierre Druilhe; L B Mohamed
Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3.
Nature medicine 2000;6(11):1258-63.
2000: Louise A Duits; Jan A M Langermans; S Paltansing; Tahar van der Straaten; Richard Vervenne; patrice frost; Pieter S Hiemstra; Alan Thomas; Peter H Nibbering
Expression of beta-defensin-1 in chimpanzee (Pan troglodytes) airways.
Journal of medical primatology 2000;29(5):318-23.
2000: Daniel M N Okenu; Alan Thomas; David J Conway
Allelic lineages of the merozoite surface protein 3 gene in Plasmodium reichenowi and Plasmodium falciparum.
Molecular and biochemical parasitology 2000;109(2):185-8.
2000: Clemens H M Kocken; D L Narum1; A Massougbodji; B Ayivi; Martin A Dubbeld; Annemarie van der Wel; David J Conway; A Sanni; Alan Thomas
Molecular characterisation of Plasmodium reichenowi apical membrane antigen-1 (AMA-1), comparison with P. falciparum AMA-1, and antibody-mediated inhibition of red cell invasion.
Molecular and biochemical parasitology 2000;109(2):147-56.
2000: Lbachir BenMohamed; Alan Thomas; Marc Bossus; Karima Brahimi; J Wubben; Hélène Gras-Masse; Pierre Druilhe
High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules.
Vaccine 2000;18(25):2843-55.
2000: David Narum; Solabomi A Ogun; Alan Thomas; Anthony A Holder
Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection.
Infection and immunity 2000;68(5):2899-906.
1999: Clemens H M Kocken; Annemarie van der Wel; Alan Thomas
Plasmodium cynomolgi: transfection of blood-stage parasites using heterologous DNA constructs.
Experimental parasitology 1999;93(1):58-60.
1999: Manlio Di Cristina; F Ghouze; C H Kocken; S Naitza; P Cellini; Dominique Soldati; Alan Thomas; Andrea Crisanti
Transformed Toxoplasma gondii tachyzoites expressing the circumsporozoite protein of Plasmodium knowlesi elicit a specific immune response in rhesus monkeys.
Infection and immunity 1999;67(4):1677-82.
1999: Clemens H M Kocken; Martin A Dubbeld; Annemarie van der Wel; Jack Pronk; Andrew P Waters; Jan A M Langermans; Alan Thomas
High-level expression of Plasmodium vivax apical membrane antigen 1 (AMA-1) in Pichia pastoris: strong immunogenicity in Macaca mulatta immunized with P. vivax AMA-1 and adjuvant SBAS2.
Infection and immunity 1999;67(1):43-9.
1998: AM Tomas; Annemarie van der Wel; Alan Thomas; C J Janse; A P Waters
Transfection systems for animal models of malaria.
Parasitology today (Personal ed.) 1998;14(6):245-9.
1998: Tania F de Koning-Ward; Alan Thomas; Andrew P Waters; Chris J Janse
Stable expression of green fluorescent protein in blood and mosquito stages of Plasmodium berghei.
Molecular and biochemical parasitology 1998;97(1-2):247-52.
1998: R Vinkenoog; Márcia A Sperança; Jai Ramesar; Alan Thomas; Hernando A del Portillo; Chris J Janse; Andrew P Waters
Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei.
Molecular and biochemical parasitology 1998;95(2):229-40.
1998: AM Tomas; Annemarie van der Wel; Alan Thomas; C J Janse; A P Waters
Erratum.
Parasitology today (Personal ed.) 1998;14(8):336.
1998: R Vinkenoog; Márcia A Sperança; O van Breemen; Jai Ramesar; Donald H Williamson; P B Ross-MacDonald; Alan Thomas; Chris J Janse; Hernando A del Portillo; Andrew P Waters
Malaria parasites contain two identical copies of an elongation factor 1 alpha gene.
Molecular and biochemical parasitology 1998;94(1):1-12.
1998: Clemens H M Kocken; Annemarie van der Wel; Martin A Dubbeld; David Narum; F M van de Rijke; Geert-Jan van Gemert; X van der Linde; Lawrence H Bannister; Chris J Janse; Andrew P Waters; Alan Thomas
Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization.
The Journal of biological chemistry 1998;273(24):15119-24.
1998: Martin A Dubbeld; Clemens H M Kocken; Alan Thomas
Merozoite surface protein 2 of Plasmodium reichenowi is a unique mosaic of Plasmodium falciparum allelic forms and species-specific elements.
Molecular and biochemical parasitology 1998;92(1):187-92.
1998: Clemens H M Kocken; Erika Hundt; Bettina Knapp; D Brazel; B Enders; David Narum; J A Wubben; Alan Thomas
Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection.
Infection and immunity 1998;66(1):373-5.
1998: Michael Theisen; Soe Soe; Claude Oeuvray; Alan Thomas; Jens Vuust; S Danielsen; S Jepsen; Pierre Druilhe
The glutamate-rich protein (GLURP) of Plasmodium falciparum is a target for antibody-dependent monocyte-mediated inhibition of parasite growth in vitro.
Infection and immunity 1998;66(1):11-7.
1997: Jeffrey A Lyon; J M Carter; Alan Thomas; J D Chulay
Merozoite surface protein-1 epitopes recognized by antibodies that inhibit Plasmodium falciparum merozoite dispersal.
Molecular and biochemical parasitology 1997;90(1):223-34.
1997: Andrew P Waters; Alan Thomas; Melissa R van Dijk; Chris J Janse
Transfection of malaria parasites.
Methods (San Diego, Calif.) 1997;13(2):134-47.
1997: Hastings Ozwara; H Niphuis; L Buijs; M Jonker; Jonathan Luke Heeney; C S Bambra; Alan Thomas; Jan A M Langermans
Flow cytometric analysis on reactivity of human T lymphocyte-specific and cytokine-receptor-specific antibodies with peripheral blood mononuclear cells of chimpanzee (Pan troglodytes), rhesus macaque (Macaca mulatta), and squirrel monkey (Saimiri sciureus)
Journal of medical primatology 1997;26(3):164-71.
1997: Lbachir BenMohamed; Hélène Gras-Masse; Andre Tartar; P Daubersies; Karima Brahimi; Marc Bossus; Alan Thomas; Pierre Druilhe
Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees.
European journal of immunology 1997;27(5):1242-53.
1997: Annemarie van der Wel; A M Tomás; Clemens H M Kocken; P Malhotra; Chris J Janse; Andrew P Waters; Alan Thomas
Transfection of the primate malaria parasite Plasmodium knowlesi using entirely heterologous constructs.
The Journal of experimental medicine 1997;185(8):1499-503.
1996: Clemens H M Kocken; Annemarie van der Wel; B Rosenwirth; Alan Thomas
Plasmodium vivax: in vitro antiparasitic effect of cyclosporins.
Experimental parasitology 1996;84(3):439-43.
1996: Clemens H M Kocken; Alan Thomas
Rapid screening and mapping of conformational epitopes expressed in the secretion expression system Pichia pastoris.
Analytical biochemistry 1996;239(1):111-2.
1996: Michael J Blackman; E D Dennis; E M Hirst; Clemens H M Kocken; T J Scott-Finnigan; Alan Thomas
Plasmodium knowlesi: secondary processing of the malaria merozoite surface protein-1.
Experimental parasitology 1996;83(2):229-39.
1995: Alan Thomas; S Hererra
Animal research.
Nature 1995;373(6512):279.
1994: Alan Thomas; J F Trape; C Rogier; A Goncalves; V E Rosario; David Narum
High prevalence of natural antibodies against Plasmodium falciparum 83-kilodalton apical membrane antigen (PF83/AMA-1) as detected by capture-enzyme-linked immunosorbent assay using full-length baculovirus recombinant PF83/AMA-1.
The American journal of tropical medicine and hygiene 1994;51(6):730-40.
1994: Fidock David; S Sallenave-Sales; J A Sherwood; G S Gachihi; M F Ferreira-da-Cruz; Alan Thomas; Pierre Druilhe
Conservation of the Plasmodium falciparum sporozoite surface protein gene, STARP, in field isolates and distinct species of Plasmodium.
Molecular and biochemical parasitology 1994;67(2):255-67.
1994: David Narum; Alan Thomas
Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites.
Molecular and biochemical parasitology 1994;67(1):59-68.
1994: Alan Thomas; D Narum; Andrew P Waters; J F Trape; C Rogier; A Gonçalves; V Rosario; P Druilhe; Graham H Mitchell; D Dennis
Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias.
Memórias do Instituto Oswaldo Cruz 1994;89 Suppl 2():67-70.
1994: Alan Thomas; B Slierendregt; B Mons; P Druilhe
Chimpanzees and supporting models in the study of malaria pre-erythrocytic stages.
Memórias do Instituto Oswaldo Cruz 1994;89 Suppl 2():111-4.
1993: David Narum; G W Welling; Alan Thomas
Ion-exchange-immunoaffinity purification of a recombinant baculovirus Plasmodium falciparum apical membrane antigen, PF83/AMA-1.
Journal of chromatography. A 1993;657(2):357-63.
1992: J R Davis; Joseph F Cortese; D A Herrington; J R Murphy; D F Clyde; Alan Thomas; S Baqar; M A Cochran; J Thanassi; Myron M Levine
Plasmodium falciparum: in vitro characterization and human infectivity of a cloned line.
Experimental parasitology 1992;74(2):159-68.
1991: A E Brown; H Kyle Webster; Jeffrey A Lyon; Alan Thomas; Barnyen Permpanich; M Gross
Characterization of naturally acquired antibody responses to a recombinant fragment from the N-terminus of Plasmodium falciparum glycoprotein 195.
The American journal of tropical medicine and hygiene 1991;45(5):567-73.
1991: Andrew P Waters; Alan Thomas; Graham H Mitchell; Thomas F McCutchan
Intra-generic conservation and limited inter-strain variation in a protective minor surface antigen of Plasmodium knowlesi merozoites.
Molecular and biochemical parasitology 1991;44(1):141-4.
1990: Alan Thomas; D A Carr; J M Carter; Jeffrey A Lyon
Sequence comparison of allelic forms of the Plasmodium falciparum merozoite surface antigen MSA2.
Molecular and biochemical parasitology 1990;43(2):211-20.
1990: Andrew P Waters; Alan Thomas; J A Deans; Graham H Mitchell; D E Hudson; Louis H Miller; Thomas F McCutchan; S Cohen
A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium.
The Journal of biological chemistry 1990;265(29):17974-9.
1990: Alan Thomas; Andrew P Waters; D Carr
Analysis of variation in PF83, an erythrocytic merozoite vaccine candidate antigen of Plasmodium falciparum.
Molecular and biochemical parasitology 1990;42(2):285-7.
1990: Alan Thomas; L H Bannister; Andrew P Waters
Sixty-six kilodalton-related antigens of Plasmodium knowlesi are merozoite surface antigens associated with the apical prominence.
Parasite immunology 1990;12(2):105-13.
1989: Jeffrey A Lyon; Alan Thomas; T Hall; J D Chulay
Specificities of antibodies that inhibit merozoite dispersal from malaria-infected erythrocytes.
Molecular and biochemical parasitology 1989;36(1):77-85.
1984: Alan Thomas; J A Deans; Graham H Mitchell; T Alderson; S Cohen
The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes.
Molecular and biochemical parasitology 1984;13(2):187-99.
1984: J A Deans; Alan Thomas; T Alderson; S Cohen
Biosynthesis of a putative protective Plasmodium knowlesi merozoite antigen.
Molecular and biochemical parasitology 1984;11():189-204.
1983: J A Deans; Alan Thomas; S Cohen
Stage-specific protein synthesis by asexual blood stage parasites of Plasmodium knowlesi.
Molecular and biochemical parasitology 1983;8(1):31-44.
1983: J A Deans; Alan Thomas; P M Inge; S Cohen
Stage-specific protein synthesis by asexual blood stage parasites of Plasmodium falciparum.
Molecular and biochemical parasitology 1983;8(1):45-51.
1982: J A Deans; T Alderson; Alan Thomas; Graham H Mitchell; E S Lennox; S Cohen
Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi.
Clinical and experimental immunology 1982;49(2):297-309.