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Richard Patten

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Serban P Georgescu; Juan L Iovanna; John M Kyriakis; Richard D Patten; Mark Aronovitz; Sandro Goruppi
Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.
Derek K Kong; Serban P Georgescu; Carla Cano; Mark J Aronovitz; Juan Lucio Iovanna; Richard D Patten; John M Kyriakis; Sandro Goruppi
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.
Richard D Patten; Monica R Hall-Porter
Small animal models of heart failure: development of novel therapies, past and present.

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All Publications

2011: Serban P Georgescu; Juan L Iovanna; John M Kyriakis; Richard D Patten; Mark Aronovitz; Sandro Goruppi
Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.
American journal of physiology. Cell physiology 2011;301(5):C1046-56.
2010: Derek K Kong; Serban P Georgescu; Carla Cano; Mark J Aronovitz; Juan Lucio Iovanna; Richard D Patten; John M Kyriakis; Sandro Goruppi
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.
Molecular biology of the cell 2010;21(8):1335-49.
2009: Richard D Patten; Monica R Hall-Porter
Small animal models of heart failure: development of novel therapies, past and present.
Circulation. Heart failure 2009;2(2):138-44.
2009: Cam Donaldson; Sarah Eder; Corey Baker; Mark Aronovitz; Alexandra Dabreo Weiss; Monica Hall-Porter; Feng Wang; Adam Ackerman; Richard H Karas; Jeffery D Molkentin; Richard D Patten
Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.
Circulation research 2009;104(2):265-75, 11p following 275.
2008: Rosanne Rouf; Sarah Greytak; Eric Wooten; Jing Wu; Jay Boltax; Michael Picard; Eric C Svensson; Wolfgang H Dillmann; Richard D Patten; Gordon S Huggins
Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription.
Circulation research 2008;103(5):493-501.
2008: Richard D Patten; Isaac Pourati; Mark Aronovitz; Alawi A Alsheikh-Ali; Sarah Eder; Thomas Force; Michael Mendelsohn; Richard H Karas
17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload.
Journal of cardiac failure 2008;14(3):245-53.
2008: Ho-Jin Park; Serban P Georgescu; Chuang Du; Christopher Madias; Mark Aronovitz; C Michael Welzig; Bo Wang; Ulrike Begley; Yali Zhang; Robert O Blaustein; Richard D Patten; Richard H Karas; Herbert H Van Tol; Timothy F Osborne; Hitoshi Shimano; Ronglih Liao; Mark S Link; Jonas B Galper
Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.
The Journal of clinical investigation 2008;118(1):259-71.
2007: Gordon S Huggins; John J Lepore; Sarah Greytak; Richard D Patten; Rachel McNamee; Mark Aronovitz; Paul J Wang; Guy L Reed
The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(3):H1877-82.
2007: Inga Peter; Gordon S Huggins; Amanda M Shearman; Arthur Pollak; Christopher Schmid; L Adrienne Cupples; Serkalem Demissie; Richard D Patten; Richard H Karas; David E Housman; Michael Mendelsohn; Ramachandran S Vasan; Emelia Benjamin
Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene.
Hypertension 2007;49(5):1000-6.
2007: Sandro Goruppi; Richard D Patten; Thomas Force; John M Kyriakis
Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction.
Molecular and cellular biology 2007;27(3):993-1006.
2006: Risto Kerkelä; luanda grazette; Rinat Yacobi; Cezar Iliescu; Richard D Patten; Cara Beahm; Brian Walters; Sergei Shevtsov; Stéphanie Pesant; Fred J Clubb; Anthony Rosenzweig; Robert N Salomon; Richard A Van Etten; Joseph Alroy; Jean-Bernard Durand; Thomas Force
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.
Nature medicine 2006;12(8):908-16.
2006: Dazhong Xu; Richard D Patten; Thomas Force; John M Kyriakis
Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.
Molecular and cellular biology 2006;26(13):5043-54.
2006: Xin Chen; Sergei P Shevtsov; Eileen Hsich; Lei Cui; Syed Haq; Mark Aronovitz; Risto Kerkelä; Jeffery D Molkentin; Ronglih Liao; Robert N Salomon; Richard D Patten; Thomas Force
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy.
Molecular and cellular biology 2006;26(12):4462-73.
2006: Richard D Patten; Richard H Karas
Estrogen replacement and cardiomyocyte protection.
Trends in cardiovascular medicine 2006;16(3):69-75.
2005: Paul Bridgman; Mark Aronovitz; Rahul Kakkar; Michael I Oliverio; Thomas M Coffman; William M Rand; Marvin A Konstam; Michael Mendelsohn; Richard D Patten
Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H586-92.
2005: Richard D Patten; David DeNofrio; Mohamad El-Zaru; Rahul Kakkar; Jessica Saunders; Flore Celestin; Kenneth Warner; Hassan Rastegar; Kamal R Khabbaz; James E Udelson; Marvin A Konstam; Richard H Karas
Ventricular assist device therapy normalizes inducible nitric oxide synthase expression and reduces cardiomyocyte apoptosis in the failing human heart.
Journal of the American College of Cardiology 2005;45(9):1419-24.
2004: Richard D Patten; Isaac Pourati; Mark Aronovitz; Jason Baur; Flore Celestin; Xin Chen; Ashour Michael; Syed Haq; Simone Nuedling; Christian Grohe; Thomas Force; Michael Mendelsohn; Richard H Karas
17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling.
Circulation research 2004;95(7):692-9.
2004: Teruo Noguchi; Mark Hünlich; Phillip C Camp; Kelly J Begin; Mohamed El-Zaru; Richard D Patten; Bruce J Leavitt; Frank P Ittleman; Norman R Alpert; Martin M LeWinter; Peter VanBuren
Thin-filament-based modulation of contractile performance in human heart failure.
Circulation 2004;110(8):982-7.
2004: Ashour Michael; Syed Haq; Xin Chen; Eileen Hsich; Lei Cui; Brian Walters; Zhili Shao; Kausik Bhattacharya; Heiko Kilter; Gordon S Huggins; Michele Andreucci; Muthu Periasamy; Robert N Solomon; Ronglih Liao; Richard D Patten; Jeffery D Molkentin; Thomas Force
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
The Journal of biological chemistry 2004;279(20):21383-93.
2003: Syed Haq; Heiko Kilter; Ashour Michael; Jingzang Tao; Eileen O'Leary; Xio Ming Sun; Brian Walters; Kausik Bhattacharya; Xin Chen; Lei Cui; Michele Andreucci; Anthony Rosenzweig; J Luis Guerrero; Richard D Patten; Ronglih Liao; Jeffery D Molkentin; Michael Picard; Joseph V Bonventre; Thomas Force
Deletion of cytosolic phospholipase A2 promotes striated muscle growth.
Nature medicine 2003;9(7):944-51.
2003: Martin van Eickels; Richard D Patten; Mark Aronovitz; Alawi A Alsheikh-Ali; Kim Gostyla; Flore Celestin; Christian Grohe; Michael Mendelsohn; Richard H Karas
17-beta-estradiol increases cardiac remodeling and mortality in mice with myocardial infarction.
Journal of the American College of Cardiology 2003;41(11):2084-92.
2003: Richard D Patten; Mark Aronovitz; Michael Einstein; Matthew Lambert; Natesa G Pandian; Michael Mendelsohn; Marvin A Konstam
Effects of angiotensin II receptor blockade versus angiotensin-converting-enzyme inhibition on ventricular remodelling following myocardial infarction in the mouse.
Clinical science (London, England : 1979) 2003;104(2):109-18.
2003: James E Udelson; Richard D Patten; Marvin A Konstam
New concepts in post-infarction ventricular remodeling.
Reviews in cardiovascular medicine 2003;4 Suppl 3():S3-12.
2002: Richard D Patten; Mark Aronovitz; Paul Bridgman; Natesa G Pandian
Use of pulse wave and color flow Doppler echocardiography in mouse models of human disease.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2002;15(7):708-14.
2000: Marvin A Konstam; Richard D Patten; I Thomas; T Ramahi; K La Bresh; S Goldman; W Lewis; A Gradman; K S Self; V Bittner; William M Rand; Debra Kinan; JJ Smith; T Ford; R Segal; James E Udelson
Effects of losartan and captopril on left ventricular volumes in elderly patients with heart failure: results of the ELITE ventricular function substudy.
American heart journal 2000;139(6):1081-7.
1998: Richard D Patten; James E Udelson; Marvin A Konstam
Ventricular remodeling and its prevention in the treatment of heart failure.
Current opinion in cardiology 1998;13(3):162-7.
1998: Richard D Patten; Mark Aronovitz; L Deras-Mejia; Natesa G Pandian; G G Hanak; J J Smith; Michael Mendelsohn; Marvin A Konstam
Ventricular remodeling in a mouse model of myocardial infarction.
The American journal of physiology 1998;274(5 Pt 2):H1812-20.
1998: K Taylor; Richard D Patten; JJ Smith; Mark Aronovitz; J Wight; Robert N Salomon; Marvin A Konstam
Divergent effects of angiotensin-converting enzyme inhibition and angiotensin II-receptor antagonism on myocardial cellular proliferation and collagen deposition after myocardial infarction in rats.
Journal of cardiovascular pharmacology 1998;31(5):654-60.
1997: Richard D Patten; M W Kronenberg; C R Benedict; James E Udelson; Debra Kinan; D Stewart; S Yusuf; JJ Smith; L Kilcoyne; N Dolan; Tonya R Edens; J Metherall; Marvin A Konstam
Acute and long-term effects of the angiotensin-converting enzyme inhibitor, enalapril, on adrenergic activity and sensitivity during exercise in patients with left ventricular systolic dysfunction.
American heart journal 1997;134(1):37-43.