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Javier Dotor

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Simona Serratì; Laura Bazzichi; Stefano Bombardieri; Paola Chiarugi; Anastasia Chillà; Javier Dotor; Esperanza Feijoo; Gabriella Fibbi; Elisa Giannoni; Bashar Kahaleh; Anna Laurenzana; Lucia Magnelli; Francesca Margheri; Mario Del Rosso
Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.
Itziar Otano; Jesús Prieto; Jose Ignacio Riezu; Lester Suarez; Africa Vales; Alberto Benito; Francisco Borras; Julien Crettaz; Javier Dotor; Manuela Gonzalez-Aparicio; Ruben Hernandez-Alcoceba; Esther Larrea; Stephan Menne; Cristina Olagüe; Gloria González-Aseguinolaza
Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B.
Francesca Margheri; Laura Papucci; Nicola Schiavone; Simona Serratì; Eugenio Torre; Francesca Bianchini; Lido Calorini; Anastasia Chillà; Javier Dotor; Esperanza Feijoo; Gabriella Fibbi; Anna Laurenzana; Lucia Magnelli; Mario Del Rosso
GDF5 regulates TGFß-dependent angiogenesis in breast carcinoma MCF-7 cells: in vitro and in vivo control by anti-TGFß peptides.

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All Publications

2013: Simona Serratì; Laura Bazzichi; Stefano Bombardieri; Paola Chiarugi; Anastasia Chillà; Javier Dotor; Esperanza Feijoo; Gabriella Fibbi; Elisa Giannoni; Bashar Kahaleh; Anna Laurenzana; Lucia Magnelli; Francesca Margheri; Mario Del Rosso
Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.
Arthritis and rheumatism 2013;65(1):258-69.
2012: Itziar Otano; Jesús Prieto; Jose Ignacio Riezu; Lester Suarez; Africa Vales; Alberto Benito; Francisco Borras; Julien Crettaz; Javier Dotor; Manuela Gonzalez-Aparicio; Ruben Hernandez-Alcoceba; Esther Larrea; Stephan Menne; Cristina Olagüe; Gloria González-Aseguinolaza
Modulation of regulatory T-cell activity in combination with interleukin-12 increases hepatic tolerogenicity in woodchucks with chronic hepatitis B.
Hepatology (Baltimore, Md.) 2012;56(2):474-83.
2012: Francesca Margheri; Laura Papucci; Nicola Schiavone; Simona Serratì; Eugenio Torre; Francesca Bianchini; Lido Calorini; Anastasia Chillà; Javier Dotor; Esperanza Feijoo; Gabriella Fibbi; Anna Laurenzana; Lucia Magnelli; Mario Del Rosso
GDF5 regulates TGFß-dependent angiogenesis in breast carcinoma MCF-7 cells: in vitro and in vivo control by anti-TGFß peptides.
PloS one 2012;7(11):e50342.
2012: José Luis Miguel-Carrasco; María U Moreno; Ana Baltanás; Francisco Borrás-Cuesta; Carolina Cebrián; Javier Díez; Javier Dotor; Ana Fortuño; Arantxa González; Nerea Hermida; Begoña López; Guillermo Zalba
Blockade of TGF-β 1 signalling inhibits cardiac NADPH oxidase overactivity in hypertensive rats.
Oxidative medicine and cellular longevity 2012;2012():726940.
2011: Jesús Loureiro; Pedro Majano; María Luisa Pérez-Lozano; Fernando Rodríguez-Pascual; Vicente Ruiz-Carpio; Pilar Sandoval; Rafael Selgas; Abelardo Aguilera; Patricia Albar-Vizcaíno; Francisco Borras-Cuesta; Javier Dotor; Santiago Lamas; Manuel López-Cabrera
Blocking TGF-β1 protects the peritoneal membrane from dialysate-induced damage.
Journal of the American Society of Nephrology : JASN 2011;22(9):1682-95.
2011: Laura Arribillaga; Javier Dotor; María Basagoiti; José I Riezu-Boj; Francisco Borrás-Cuesta; Juan José Lasarte; Pablo Sarobe; María Eugenia Cornet; Esperanza Feijoó
Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis.
Cytokine 2011;53(3):327-33.
2011: Nancy Díaz-Valdés; María Basagoiti; Javier Dotor; Fernando Aranda; Iñaki Monreal; José I Riezu-Boj; Francisco Borrás-Cuesta; Pablo Sarobe; Esperanza Feijoó
Induction of monocyte chemoattractant protein-1 and interleukin-10 by TGFbeta1 in melanoma enhances tumor infiltration and immunosuppression.
Cancer research 2011;71(3):812-21.
2011: Sergio Recalde; Angel Salinas-Alamán; Javier Zarranz-Ventura; Francisco Borrás-Cuesta; Javier Dotor; Patricia Fernández-Robredo; Pío J García-Gómez; Alfredo García-Layana
Transforming growth factor-β inhibition decreases diode laser-induced choroidal neovascularization development in rats: P17 and P144 peptides.
Investigative ophthalmology & visual science 2011;52(10):7090-7.
2010: Andrea San-Martín; Javier Dotor; Fernando Martinez; Bernardo Hontanilla
Effect of the inhibitor peptide of the transforming growth factor beta (p144) in a new silicone pericapsular fibrotic model in pigs.
Aesthetic plastic surgery 2010;34(4):430-7.
2010: Javier Guerrero; Nicolás Tobar; Mónica Cáceres; Lorena Espinoza; Paula Escobar; Javier Dotor; Patricio C Smith; Jorge Martínez
Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-beta1 and TNF-alpha.
Breast cancer research and treatment 2010;119(2):497-508.
2009: Diana Llopiz; Javier Dotor; Noelia Casares; Jaione Bezunartea; Nancy Díaz-Valdés; Marta Ruiz; Fernando Aranda; Pedro Berraondo; Jesús Prieto; Juan José Lasarte; Francisco Borrás-Cuesta; Pablo Sarobe
Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.
International journal of cancer. Journal international du cancer 2009;125(11):2614-23.
2009: Simona Serratì; Francesca Margheri; Marco Pucci; Anna Rita Cantelmo; Rosaria Cammarota; Javier Dotor; Francisco Borràs-Cuesta; Gabriella Fibbi; Adriana Albini; Mario Del Rosso
TGFbeta1 antagonistic peptides inhibit TGFbeta1-dependent angiogenesis.
Biochemical pharmacology 2009;77(5):813-25.
2009: Nerea Hermida; Begoña López; Arantxa González; Javier Dotor; Juan José Lasarte; Pablo Sarobe; Francisco Borrás-Cuesta; Javier Díez
A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.
Cardiovascular research 2009;81(3):601-9.
2008: Lucía Gil-Guerrero; Javier Dotor; Inge Louise Huibregtse; Noelia Casares; Ana Belén López-Vázquez; Francesc Rudilla; José Ignacio Riezu-Boj; Jacinto López-Sagaseta; José Hermida; Sander Van Deventer; Jaione Bezunartea; Diana Llopiz; Pablo Sarobe; Jesús Prieto; Francisco Borrás-Cuesta; Juan José Lasarte
In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):126-35.
2008: Silvestre Vicent; Diego Luis-Ravelo; Iker Antón; Ignacio García-Tuñón; Francisco Borrás-Cuesta; Javier Dotor; Javier De Las Rivas; Fernando Lecanda
A novel lung cancer signature mediates metastatic bone colonization by a dual mechanism.
Cancer research 2008;68(7):2275-85.
2008: María Iñiguez; Javier Dotor; Esperanza Feijoo; Saioa Goñi; Jesus Prieto; Carmen Berasain; Matías A Avila
Novel pharmacologic strategies to protect the liver from ischemia-reperfusion injury.
Recent patents on cardiovascular drug discovery 2008;3(1):9-18.
2008: Diana Llopiz; Javier Dotor; Aintzane Zabaleta; Juan José Lasarte; Jesús Prieto; Francisco Borrás-Cuesta; Pablo Sarobe
Combined immunization with adjuvant molecules poly(I:C) and anti-CD40 plus a tumor antigen has potent prophylactic and therapeutic antitumor effects.
Cancer immunology, immunotherapy : CII 2008;57(1):19-29.
2007: Eduardo Pérez-Gómez; María Villa-Morales; Javier Santos; José Fernández-Piqueras; Carlos Gamallo; Javier Dotor; Carmelo Bernabéu; Miguel Quintanilla
A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis.
Cancer research 2007;67(21):10268-77.
2007: Javier Dotor; Ana B López-Vázquez; Juan José Lasarte; Pablo Sarobe; Marta García-Granero; José I Riezu-Boj; Alfonso Martínez; Esperanza Feijoó; Jacinto López-Sagaseta; José Hermida; Jesús Prieto; Francisco Borrás-Cuesta
Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library.
Cytokine 2007;39(2):106-15.
2007: Carlos Ocaña-Morgner; Kurt A Wong; Flavia Lega; Javier Dotor; Francisco Borras-Cuesta; Ana Rodriguez
Role of TGF-beta and PGE2 in T cell responses during Plasmodium yoelii infection.
European journal of immunology 2007;37(6):1562-74.
2007: Aintzane Zabaleta; Laura Arribillaga; Diana Llopiz; Javier Dotor; Juan José Lasarte; Jesús Prieto; Francisco Borrás-Cuesta; Juan Ignacio Esteban; Josep Quer; Francesc Vayreda; Pablo Sarobe
Induction of potent and long-lasting CD4 and CD8 T-cell responses against hepatitis C virus by immunization with viral antigens plus poly(I:C) and anti-CD40.
Antiviral research 2007;74(1):25-35.
2006: María L Martínez-Chantar; Mercedes vázquez-chantada; Marta Garnacho; M Ujue Latasa; Marta Varela-Rey; Javier Dotor; Monica Santamaria; Luis A Martínez-Cruz; Luis A Parada; Shelly C Lu; José M Mato
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Gastroenterology 2006;131(1):223-32.
2005: Begoña Santiago; Irene Gutierrez-Cañas; Javier Dotor; Guillermo Palao; Juan José Lasarte; Juan Ruiz; Jesús Prieto; Francisco Borrás-Cuesta; José L Pablos
Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis.
The Journal of investigative dermatology 2005;125(3):450-5.
2003: Noelia Casares; Laura Arribillaga; Pablo Sarobe; Javier Dotor; Ascensión Lopez-Diaz de Cerio; Ignacio Melero; Jesús Prieto; Francisco Borrás-Cuesta; Juan José Lasarte
CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5931-9.
2003: Ignacio-José Ezquerro; Juan José Lasarte; Javier Dotor; Inma Castilla-Cortázar; Matilde Bustos; Iván Peñuelas; Gemma Blanco; Carlos Rodríguez; Maria del Carmen G Lechuga; Patricia Greenwel; Marcos Rojkind; Jesús Prieto; Francisco Borrás-Cuesta
A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury.
Cytokine 2003;22(1-2):12-20.
2002: Eduardo Huarte; Pablo Sarobe; Jun Lu; Noelia Casares; Juan José Lasarte; Javier Dotor; Marta Ruiz; Jesús Prieto; Esteban Celis; Francisco Borrás-Cuesta
Enhancing immunogenicity of a CTL epitope from carcinoembryonic antigen by selective amino acid replacements.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2336-44.