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Yosef Shaul

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TOP 3
Oren Moscovitz; Yosef Shaul; Peter Tsvetkov; Gili Ben-Nissan; Nimrod Hazan; Hodaya Keisar; Izhak M. Michaelevski; Michal Sharon
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
Peter Tsvetkov; Yosef Shaul
Determination of IUP based on susceptibility for degradation by default.
Peter Tsvetkov; Oren Moscovitz; Nadav Myers; Jaime Prilusky; Michal Sharon; Yosef Shaul
Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates.

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2012: Oren Moscovitz; Yosef Shaul; Peter Tsvetkov; Gili Ben-Nissan; Nimrod Hazan; Hodaya Keisar; Izhak M. Michaelevski; Michal Sharon
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
Molecular cell 2012;47(1):76-86.
2012: Peter Tsvetkov; Yosef Shaul
Determination of IUP based on susceptibility for degradation by default.
Methods in molecular biology (Clifton, N.J.) 2012;895():3-18.
2012: Peter Tsvetkov; Oren Moscovitz; Nadav Myers; Jaime Prilusky; Michal Sharon; Yosef Shaul
Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates.
Molecular bioSystems 2012;8(1):368-73.
2011: Marcin J Suskiewicz; Joel L Sussman; Israel Silman; Yosef Shaul
Context-dependent resistance to proteolysis of intrinsically disordered proteins.
Protein science : a publication of the Protein Society 2011;20(8):1285-97.
2011: Iddo Bar-Yishay; Yosef Shaul; Amir Shlomai
Hepatocyte metabolic signalling pathways and regulation of hepatitis B virus expression.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(3):282-90.
2010: Yosef Shaul; Nina Reuven
The role of p53 in nutrients levels.
Cell cycle (Georgetown, Tex.) 2010;9(18):3646-7.
2010: Julia Adler; Nina Reuven; Chaim Kahana; Yosef Shaul
c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.
Molecular and cellular biology 2010;30(15):3767-78.
2010: Dorit Cohen; Yaarit Adamovich; Nina Reuven; Yosef Shaul
Hepatitis B virus activates deoxynucleotide synthesis in nondividing hepatocytes by targeting the R2 gene.
Hepatology (Baltimore, Md.) 2010;51(5):1538-46.
2010: V Meltser; Merav Ben-Yehoyada; Nina Reuven; Yosef Shaul
c-Abl downregulates the slow phase of double-strand break repair.
Cell death & disease 2010;1():e20.
2010: P Tsvetkov; Nina Reuven; Yosef Shaul
Ubiquitin-independent p53 proteasomal degradation.
Cell death and differentiation 2010;17(1):103-8.
2009: Amir Shlomai; Yoav Lubelsky; Ofir Har-Noy; Yosef Shaul
The "Trojan horse" model-delivery of anti-HBV small interfering RNAs by a recombinant HBV vector.
Biochemical and biophysical research communications 2009;390(3):619-23.
2009: Peter Tsvetkov; Nina Reuven; Yosef Shaul
The nanny model for IDPs.
Nature chemical biology 2009;5(11):778-81.
2009: Peter Tsvetkov; Nina Reuven; Carol Prives; Yosef Shaul
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.
The Journal of biological chemistry 2009;284(39):26234-42.
2009: Amir Shlomai; Yosef Shaul
The metabolic activator FOXO1 binds hepatitis B virus DNA and activates its transcription.
Biochemical and biophysical research communications 2009;381(4):544-8.
2008: Dan Levy; Nina Reuven; Yosef Shaul
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
The Journal of biological chemistry 2008;283(41):27462-8.
2008: Peter Tsvetkov; Gad Asher; Aviv Paz; Nina Reuven; Joel Sussman; Israel Silman; Yosef Shaul
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
Proteins 2008;70(4):1357-66.
2008: Dan Levy; Yaarit Adamovich; Nina Reuven; Yosef Shaul
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.
Molecular cell 2008;29(3):350-61.
2008: Amir Shlomai; Yosef Shaul
The "metabolovirus" model of hepatitis B virus suggests nutritional therapy as an effective anti-viral weapon.
Medical hypotheses 2008;71(1):53-7.
2007: Yosef Shaul; Rony Seger
The MEK/ERK cascade: from signaling specificity to diverse functions.
Biochimica et biophysica acta 2007;1773(8):1213-26.
2007: D Levy; Y Adamovich; Nina Reuven; Yosef Shaul
The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.
Cell death and differentiation 2007;14(4):743-51.
2006: Amir Shlomai; Nir Paran; Yosef Shaul
PGC-1alpha controls hepatitis B virus through nutritional signals.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(43):16003-8.
2006: Gad Asher; Nina Reuven; Yosef Shaul
20S proteasomes and protein degradation "by default".
BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(8):844-9.
2006: Arik Cooper; Yosef Shaul
Clathrin-mediated endocytosis and lysosomal cleavage of hepatitis B virus capsid-like core particles.
The Journal of biological chemistry 2006;281(24):16563-9.
2006: Gad Asher; Orly Dym; Peter Tsvetkov; Julia Adler; Yosef Shaul
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.
Biochemistry 2006;45(20):6372-8.
2006: Gad Asher; Yosef Shaul
Ubiquitin-independent degradation: lessons from the p53 model.
The Israel Medical Association journal : IMAJ 2006;8(4):229-32.
2006: Yosef Shaul; Rony Seger
ERK1c regulates Golgi fragmentation during mitosis.
The Journal of cell biology 2006;172(6):885-97.
2006: Gideon Schreiber; Yosef Shaul; Kay-Eberhard Gottschalk
Electrostatic design of protein-protein association rates.
Methods in molecular biology (Clifton, N.J.) 2006;340():235-49.
2005: Yoav Lubelsky; Nina Reuven; Yosef Shaul
Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest.
Molecular and cellular biology 2005;25(23):10665-73.
2005: Chaim Kahana; Gad Asher; Yosef Shaul
Mechanisms of protein degradation: an odyssey with ODC.
Cell cycle (Georgetown, Tex.) 2005;4(11):1461-4.
2005: Arik Cooper; Guy Tal; Ofer Lider; Yosef Shaul
Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3165-76.
2005: Yosef Shaul; Gideon Schreiber
Exploring the charge space of protein-protein association: a proteomic study.
Proteins 2005;60(3):341-52.
2005: Gad Asher; Yosef Shaul
p53 proteasomal degradation: poly-ubiquitination is not the whole story.
Cell cycle (Georgetown, Tex.) 2005;4(8):1015-8.
2005: Peter Tsvetkov; Gad Asher; Veronica Reiss; Yosef Shaul; Leo Sachs; Joseph Lotem
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(15):5535-40.
2005: Gad Asher; Zippi Bercovich; Peter Tsvetkov; Yosef Shaul; Chaim Kahana
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1.
Molecular cell 2005;17(5):645-55.
2005: Arik Cooper; Yosef Shaul
Recombinant viral capsids as an efficient vehicle of oligonucleotide delivery into cells.
Biochemical and biophysical research communications 2005;327(4):1094-9.
2005: Gad Asher; Peter Tsvetkov; Chaim Kahana; Yosef Shaul
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73.
Genes & development 2005;19(3):316-21.
2005: Yosef Shaul; Merav Ben-Yehoyada
Role of c-Abl in the DNA damage stress response.
Cell research 2005;15(1):33-5.
2004: Amir Shlomai; Yosef Shaul
RNA interference--small RNAs effectively fight viral hepatitis.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(6):526-31.
2004: Daniel M Aebersold; Yosef Shaul; Yuval Yung; Nirit Yarom; Zhong Yao; Tamar Hanoch; Rony Seger
Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function.
Molecular and cellular biology 2004;24(22):10000-15.
2004: Gilad Doitsh; Yosef Shaul
Enhancer I predominance in hepatitis B virus gene expression.
Molecular and cellular biology 2004;24(4):1799-808.
2004: Gad Asher; Joseph Lotem; Leo Sachs; Yosef Shaul
p53-dependent apoptosis and NAD(P)H:quinone oxidoreductase 1.
Methods in enzymology 2004;382():278-93.
2004: Yosef Shaul; Rony Seger
Use of inhibitors in the study of MAPK signaling.
Methods in molecular biology (Clifton, N.J.) 2004;250():113-26.
2003: Gad Asher; Joseph Lotem; Peter Tsvetkov; Veronica Reiss; Leo Sachs; Yosef Shaul
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15065-70.
2003: Merav Ben-Yehoyada; Israel Ben-Dor; Yosef Shaul
c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association.
The Journal of biological chemistry 2003;278(36):34475-82.
2003: Arik Cooper; Nir Paran; Yosef Shaul
The earliest steps in hepatitis B virus infection.
Biochimica et biophysica acta 2003;1614(1):89-96.
2003: Gilad Doitsh; Yosef Shaul
A long HBV transcript encoding pX is inefficiently exported from the nucleus.
Virology 2003;309(2):339-49.
2003: Nir Paran; Arik Cooper; Yosef Shaul
Interaction of hepatitis B virus with cells.
Reviews in medical virology 2003;13(3):137-43.
2003: Amir Shlomai; Yosef Shaul
Inhibition of hepatitis B virus expression and replication by RNA interference.
Hepatology (Baltimore, Md.) 2003;37(4):764-70.
2002: Gad Asher; Joseph Lotem; Leo Sachs; Chaim Kahana; Yosef Shaul
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13125-30.
2002: Vladimir Litvak; Yosef Shaul; Mark Shulewitz; Roy Amarilio; Shari Carmon; Sima Lev
Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain.
Current biology : CB 2002;12(17):1513-8.
2002: Romy Zemel; Claud Koren; Larisa Bachmatove; Smadar Avigad; Ella Kaganovsky; Elimelech Okon; Ziv Ben-Ari; Franklin Grief; Merav Ben-Yehoyada; Yosef Shaul; Ran Tur-Kaspa
p73 overexpression and nuclear accumulation in hepatitis C virus-associated hepatocellular carcinoma.
Digestive diseases and sciences 2002;47(4):716-22.
2002: MEIR SHAMAY; Orr Barak; Yosef Shaul
HBXAP, a novel PHD-finger protein, possesses transcription repression activity.
Genomics 2002;79(4):523-9.
2002: MEIR SHAMAY; Orr Barak; Gilad Doitsh; Israel Ben-Dor; Yosef Shaul
Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription.
The Journal of biological chemistry 2002;277(12):9982-8.
2002: Gad Asher; Joseph Lotem; Rachel Kama; Leo Sachs; Yosef Shaul
NQO1 stabilizes p53 through a distinct pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3099-104.
2001: MEIR SHAMAY; R Agami; Yosef Shaul
HBV integrants of hepatocellular carcinoma cell lines contain an active enhancer.
Oncogene 2001;20(47):6811-9.
2001: Nir Paran; Benjamin Geiger; Yosef Shaul
HBV infection of cell culture: evidence for multivalent and cooperative attachment.
The EMBO journal 2001;20(16):4443-53.
2001: Y Katan-Khaykovich; Yosef Shaul
Nuclear import and DNA-binding activity of RFX1. Evidence for an autoinhibitory mechanism.
European journal of biochemistry / FEBS 2001;268(10):3108-16.
2001: Orr Barak; Ami Aronheim; Yosef Shaul
HBV X protein targets HIV Tat-binding protein 1.
Virology 2001;283(1):110-20.
2001: Gad Asher; Joseph Lotem; B Cohen; Leo Sachs; Yosef Shaul
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1188-93.
2000: Vladimir Litvak; Donghua Tian; Yosef Shaul; Sima Lev
Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades.
The Journal of biological chemistry 2000;275(42):32736-46.
2000: Nir Paran; A Ori; Izhak Haviv; Yosef Shaul
A composite polyadenylation signal with TATA box function.
Molecular and cellular biology 2000;20(3):834-41.
2000: Yosef Shaul
c-Abl: activation and nuclear targets.
Cell death and differentiation 2000;7(1):10-6.
1999: Gilad Doitsh; Yosef Shaul
HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX.
Oncogene 1999;18(52):7506-13.
1999: Y Katan-Khaykovich; Ivo Spiegel; Yosef Shaul
The dimerization/repression domain of RFX1 is related to a conserved region of its yeast homologues Crt1 and Sak1: a new function for an ancient motif.
Journal of molecular biology 1999;294(1):121-37.
1999: R Agami; Giovanni Blandino; Moshe Oren; Yosef Shaul
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.
Nature 1999;399(6738):809-13.
1998: Y Katan-Khaykovich; Yosef Shaul
RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes.
The Journal of biological chemistry 1998;273(38):24504-12.
1998: I Berger; Yosef Shaul
c-Fos antagonizes the junD gene positive autoregulatory loop; a novel c-Fos role in promoter switching.
Gene 1998;211(2):375-82.
1998: Izhak Haviv; Y Matza; Yosef Shaul
pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants.
Genes & development 1998;12(8):1217-26.
1998: R Agami; Yosef Shaul
The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes.
Oncogene 1998;16(14):1779-88.
1998: Izhak Haviv; MEIR SHAMAY; Gilad Doitsh; Yosef Shaul
Hepatitis B virus pX targets TFIIB in transcription coactivation.
Molecular and cellular biology 1998;18(3):1562-9.
1998: A Ori; Ayelet Zauberman; Gilad Doitsh; Nir Paran; Moshe Oren; Yosef Shaul
p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53.
The EMBO journal 1998;17(2):544-53.
1997: Y Katan; R Agami; Yosef Shaul
The transcriptional activation and repression domains of RFX1, a context-dependent regulator, can mutually neutralize their activities.
Nucleic acids research 1997;25(18):3621-8.
1996: Izhak Haviv; D Vaizel; Yosef Shaul
pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner.
The EMBO journal 1996;15(13):3413-20.
1996: R Dikstein; R Agami; D Heffetz; Yosef Shaul
p140/c-Abl that binds DNA is preferentially phosphorylated at tyrosine residues.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2387-91.
1995: S Noiman; Yosef Shaul
Detection of histidine-phospho-proteins in animal tissues.
FEBS letters 1995;364(1):63-6.
1995: A Ori; Yosef Shaul
Hepatitis B virus enhancer binds and is activated by the Hepatocyte nuclear factor 3.
Virology 1995;207(1):98-106.
1995: E Shaulian; Izhak Haviv; Yosef Shaul; Moshe Oren
Transcriptional repression by the C-terminal domain of p53.
Oncogene 1995;10(4):671-80.
1995: Izhak Haviv; D Vaizel; Yosef Shaul
The X protein of hepatitis B virus coactivates potent activation domains.
Molecular and cellular biology 1995;15(2):1079-85.
1994: A Ori; D Atzmony; Izhak Haviv; Yosef Shaul
An NF1 motif plays a central role in hepatitis B virus enhancer.
Virology 1994;204(2):600-8.
1994: T De-Medina; Yosef Shaul
Functional and structural similarity between the X protein of hepatitis B virus and nucleoside diphosphate kinases.
FEBS letters 1994;351(3):423-6.
1994: T de-Medina; Izhak Haviv; S Noiman; Yosef Shaul
The X protein of hepatitis B virus has a ribo/deoxy ATPase activity.
Virology 1994;202(1):401-7.
1994: I Berger; Yosef Shaul
The human junD gene is positively and selectively autoregulated.
DNA and cell biology 1994;13(3):249-55.
1992: R Dikstein; D Heffetz; Y Ben-Neriah; Yosef Shaul
c-abl has a sequence-specific enhancer binding activity.
Cell 1992;69(5):751-7.
1991: I Berger; Yosef Shaul
Structure and function of human jun-D.
Oncogene 1991;6(4):561-6.
1990: R Dikstein; O Faktor; Yosef Shaul
Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.
Molecular and cellular biology 1990;10(8):4427-30.
1990: R Dikstein; O Faktor; R Ben-Levy; Yosef Shaul
Functional organization of the hepatitis B virus enhancer.
Molecular and cellular biology 1990;10(7):3683-9.
1990: O Faktor; Yosef Shaul
The identification of hepatitis B virus X gene responsive elements reveals functional similarity of X and HTLV-I tax.
Oncogene 1990;5(6):867-72.
1990: Tamar Unger; Yosef Shaul
The X protein of the hepatitis B virus acts as a transcription factor when targeted to its responsive element.
The EMBO journal 1990;9(6):1889-95.
1990: O Faktor; S Budlovsky; R Ben-Levy; Yosef Shaul
A single element within the hepatitis B virus enhancer binds multiple proteins and responds to multiple stimuli.
Journal of virology 1990;64(4):1861-3.
1989: R Ben-Levy; O Faktor; I Berger; Yosef Shaul
Cellular factors that interact with the hepatitis B virus enhancer.
Molecular and cellular biology 1989;9(4):1804-9.
1989: J Honigwachs; O Faktor; R Dikstein; Yosef Shaul; O Laub
Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer.
Journal of virology 1989;63(2):919-24.
1988: T De-Medina; O Faktor; Yosef Shaul
The S promoter of hepatitis B virus is regulated by positive and negative elements.
Molecular and cellular biology 1988;8(6):2449-55.
1988: O Faktor; T De-Medina; Yosef Shaul
Regulation of hepatitis B virus S gene promoter in transfected cell lines.
Virology 1988;162(2):362-8.
1987: Yosef Shaul; R Ben-Levy
Multiple nuclear proteins in liver cells are bound to hepatitis B virus enhancer element and its upstream sequences.
The EMBO journal 1987;6(7):1913-20.
1987: I Berger; Yosef Shaul
Integration of hepatitis B virus: analysis of unoccupied sites.
Journal of virology 1987;61(4):1180-6.
1986: Yosef Shaul; R Ben-Levy; T De-Medina
High affinity binding site for nuclear factor I next to the hepatitis B virus S gene promoter.
The EMBO journal 1986;5(8):1967-71.
1985: Yosef Shaul; O Laub; M D Walker; W J Rutter
Homologous recombination between a defective virus and a chromosomal sequence in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(11):3781-4.
1985: Yosef Shaul; W J Rutter; O Laub
A human hepatitis B viral enhancer element.
The EMBO journal 1985;4(2):427-30.
1983: O Laub; L B Rall; M Truett; Yosef Shaul; D N Standring; P Valenzuela; W J Rutter
Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region.
Journal of virology 1983;48(1):271-80.