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Kjell Sakariassen

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Kjell S Sakariassen; Alexandra S Sorensen; Pēteris Alberts; Arnaldo R Armesto; Marco Cattaneo; Federico Manuel Daray; Andrea Emilse Errasti; Eti A Femia; Jean-Philippe Meyer; Wanda Nowak; Gian M Podda; Mariateresa Pugliano; Cristina Razzari; Rodolfo Pedro Rothlin
EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin.
Antonio Tello-Montoliu; Bhaloo Desai; Giuseppe Pasqualino; Ronakkumar Patel; Fabiana Rollini; Kjell S Sakariassen; Alexandra Santana Sorensen; Dominick J Angiolillo
Pharmacodynamic effects of EV-077: results of an in vitro pilot investigation in healthy volunteers.
Nicholas Pugh; Kjell S Sakariassen; Bill Davis; Gavin E Jarvis; Annelize Koch; Richard W Farndale
The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface.

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2012: Kjell S Sakariassen; Alexandra S Sorensen; Pēteris Alberts; Arnaldo R Armesto; Marco Cattaneo; Federico Manuel Daray; Andrea Emilse Errasti; Eti A Femia; Jean-Philippe Meyer; Wanda Nowak; Gian M Podda; Mariateresa Pugliano; Cristina Razzari; Rodolfo Pedro Rothlin
EV-077 in vitro inhibits platelet aggregation in type-2 diabetics on aspirin.
Thrombosis research 2012;130(5):746-52.
2012: Antonio Tello-Montoliu; Bhaloo Desai; Giuseppe Pasqualino; Ronakkumar Patel; Fabiana Rollini; Kjell S Sakariassen; Alexandra Santana Sorensen; Dominick J Angiolillo
Pharmacodynamic effects of EV-077: results of an in vitro pilot investigation in healthy volunteers.
Journal of thrombosis and thrombolysis 2012;34(3):297-9.
2012: Nicholas Pugh; Kjell S Sakariassen; Bill Davis; Gavin E Jarvis; Annelize Koch; Richard W Farndale
The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface.
Journal of thrombosis and thrombolysis 2012;33(1):6-15.
2009: Kjell S Sakariassen; Peteris Alberts; Pierre Fontana; Jessica Mann; Henri Bounameaux; Alexandra Santana Sorensen
Effect of pharmaceutical interventions targeting thromboxane receptors and thromboxane synthase in cardiovascular and renal diseases.
Future cardiology 2009;5(5):479-93.
2007: Kjell S Sakariassen; Lars Orning
Validation of the human tissue factor/FVIIa complex as an antithrombotic target and the discovery of a synthetic peptide.
Future cardiology 2007;3(3):249-62.
2007: Kjell S Sakariassen
Thrombus formation on apex of arterial stenoses: the need for a fluid high shear stenosis diagnostic device.
Future cardiology 2007;3(2):193-201.
2007: Kjell S Sakariassen
Blood flow devices in medical research and clinical testing in humans: are we approaching personalized medicine?
Future cardiology 2007;3(1):71-90.
2005: Kjell S Sakariassen
Biopharma in Piedmont, Italy.
Nature reviews. Drug discovery 2005;4(6):519.
2005: Yves Cadroy; Claire Thalamas; Kjell S Sakariassen; Bernard Boneu
Superior efficacy of clopidogrel plus acetylsalicylic acid compared with extended-release dipyridamole plus acetylsalicylic acid in preventing arterial thrombogenesis in healthy volunteers.
Thrombosis research 2005;116(4):293-300.
2002: Yves Cadroy; Fabien Pillard; Kjell S Sakariassen; Claire Thalamas; Bernard Boneu; Daniel Riviere
Strenuous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(3):829-33.
2002: Hilde Kanli Galtung; Vibeke Sørlundsengen; Kjell S Sakariassen; Haakon B Benestad
Effect of radiologic contrast media on cell volume regulatory mechanisms in human red blood cells.
Academic radiology 2002;9(8):878-85.
2002: Lars Orning; Peter M Fischer; Chih-Kao Hu; Erik Agner; May Engebretsen; Mette Husbyn; Lizette B Petersen; Una Orvim; Miguel Llinas; Kjell S Sakariassen
A cyclic pentapeptide derived from the second EGF-like domain of Factor VII is an inhibitor of tissue factor dependent coagulation and thrombus formation.
Thrombosis and haemostasis 2002;87(1):13-21.
2001: Yves Cadroy; Kjell S Sakariassen; J P Charlet; Claire Thalamas; Bernard Boneu; P Sie
Role of 4 platelet membrane glycoprotein polymorphisms on experimental arterial thrombus formation in men.
Blood 2001;98(10):3159-61.
2001: Kjell S Sakariassen; Stephen R Hanson; Yves Cadroy
Methods and models to evaluate shear-dependent and surface reactivity-dependent antithrombotic efficacy.
Thrombosis research 2001;104(3):149-74.
2001: Chih-Kao Hu; Miguel Llinás; K E Agner; Lars Orning; Kjell S Sakariassen; Peter M Fischer
Synthesis, biological activity, and solution structures of a cyclic dodecapeptide from the EGF-2 domain of blood coagulation factor VII.
The journal of peptide research : official journal of the American Peptide Society 2001;57(6):462-72.
2001: Yves Cadroy; Kjell S Sakariassen; Hélène Grandjean; Claire Thalamas; Bernard Boneu; Pierre Sié
The effect of platelet PlA polymorphism on experimental thrombus formation in man depends on blood flow and thrombogenic substrate.
Thrombosis and haemostasis 2001;85(6):1097-103.
2001: Hilde Kanli Galtung; M Løken; Kjell S Sakariassen
Effect of radiologic contrast media on cell volume regulation in rabbit proximal renal tubules.
Academic radiology 2001;8(5):398-404.
2000: Hilde Kanli Galtung; M Løken; Kjell S Sakariassen
Effect of radiologic contrast material on cell volume regulation in proximal renal tubules from trout (Salmo trutta).
Academic radiology 2000;7(11):911-9.
2000: Yves Cadroy; Jean-Pierre Bossavy; Claire Thalamas; L Sagnard; Kjell S Sakariassen; Bernard Boneu
Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans.
Circulation 2000;101(24):2823-8.
2000: RM Barstad; Ross W Stephens; MJ Hamers; Kjell S Sakariassen
Protamine sulphate inhibits platelet membrane glycoprotein Ib-von Willebrand factor activity.
Thrombosis and haemostasis 2000;83(2):334-7.
1999: Jean-Pierre Bossavy; Kjell S Sakariassen; Claire Thalamas; Bernard Boneu; Yves Cadroy
Antithrombotic efficacy of the vitamin K antagonist fluindione in a human Ex vivo model of arterial thrombosis : effect of anticoagulation level and combination therapy with aspirin.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2269-75.
1999: Jean-Pierre Bossavy; Yves Cadroy; Kjell S Sakariassen; Bernard Boneu; André Barret
Nonfractionated heparin fails to inhibit arterial thrombosis in a human ex vivo thrombosis model.
Annals of vascular surgery 1999;13(4):393-401.
1999: Jean-Pierre Bossavy; Kjell S Sakariassen; Klaus Ruebsamen; Claire Thalamas; Bernard Boneu; Yves Cadroy
Comparison of the antithrombotic effect of PEG-hirudin and heparin in a human ex vivo model of arterial thrombosis.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1348-53.
1998: Kjell S Sakariassen; Pål Andre Holme; Una Orvim; RM Barstad; Nils Olav Solum; Frank Brosstad
Shear-induced platelet activation and platelet microparticle formation in native human blood.
Thrombosis research 1998;92(6 Suppl 2):S33-41.
1998: Lars Orning; B E Arbo; Peter M Fischer; Kjell S Sakariassen
A peptide sequence from mouse tissue factor inhibits human tissue factor dependent factor X activation.
Thrombosis research 1998;92(3):135-40.
1998: Jean-Pierre Bossavy; Claire Thalamas; L Sagnard; André Barret; Kjell S Sakariassen; Bernard Boneu; Yves Cadroy
A double-blind randomized comparison of combined aspirin and ticlopidine therapy versus aspirin or ticlopidine alone on experimental arterial thrombogenesis in humans.
Blood 1998;92(5):1518-25.
1998: Kjell S Sakariassen; M Buchmann; MJ Hamers; Helge Stormorken
Iohexol, platelet activation and thrombosis. II. Iohexol-induced platelet secretion does not affect collagen-induced or tissue-factor-induced thrombus formation in blood that is anticoagulated with heparin and aspirin.
Acta radiologica (Stockholm, Sweden : 1987) 1998;39(4):355-61.
1998: Kjell S Sakariassen; RM Barstad; MJ Hamers; Helge Stormorken
Iohexol, platelet activation and thrombosis. I. Iohexol-induced platelet secretion does not affect thrombus formation in native blood.
Acta radiologica (Stockholm, Sweden : 1987) 1998;39(4):349-54.
1998: Stephen R Hanson; Kjell S Sakariassen
Blood flow and antithrombotic drug effects.
American heart journal 1998;135(5 Pt 2 Su):S132-45.
1998: RM Barstad; MJ Hamers; A S Møller; Kjell S Sakariassen
Monocyte procoagulant activity induced by adherence to an artificial surface is reduced by end-point immobilized heparin-coating of the surface.
Thrombosis and haemostasis 1998;79(2):302-5.
1998: Jean-Pierre Bossavy; Kjell S Sakariassen; André Barret; Bernard Boneu; Yves Cadroy
A new method for quantifying platelet deposition in flowing native blood in an ex vivo model of human thrombogenesis.
Thrombosis and haemostasis 1998;79(1):162-8.
1997: Mette Husbyn; Lars Orning; Kjell S Sakariassen; Peter M Fischer
Peptides corresponding to the second epidermal growth factor-like domain of human blood coagulation factor VII: synthesis, folding and biological activity.
The journal of peptide research : official journal of the American Peptide Society 1997;50(6):475-82.
1997: Una Orvim; RM Barstad; Lars Orning; Lizette B Petersen; Mirella Ezban; Ulla Hedner; Kjell S Sakariassen
Antithrombotic efficacy of inactivated active site recombinant factor VIIa is shear dependent in human blood.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):3049-56.
1997: Helge Stormorken; Kjell S Sakariassen
Hemostatic risk factors in arterial thrombosis and atherosclerosis: the thrombin-fibrin and platelet-vWF axis.
Thrombosis research 1997;88(1):1-25.
1997: Lars Orning; Ross W Stephens; Lizette B Petersen; MJ Hamers; Helge Stormorken; Kjell S Sakariassen
A peptide sequence from the EGF-2 like domain of FVII inhibits TF-dependent FX activation.
Thrombosis research 1997;86(1):57-67.
1997: Pål Andre Holme; Una Orvim; MJ Hamers; Nils Olav Solum; Frank Brosstad; RM Barstad; Kjell S Sakariassen
Shear-induced platelet activation and platelet microparticle formation at blood flow conditions as in arteries with a severe stenosis.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(4):646-53.
1997: Yves Cadroy; Armelle Diquélou; Dominique Dupouy; Jean-Pierre Bossavy; Kjell S Sakariassen; Pierre Sié; Bernard Boneu
The thrombomodulin/protein C/protein S anticoagulant pathway modulates the thrombogenic properties of the normal resting and stimulated endothelium.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):520-7.
1997: Kjell S Sakariassen; Lars Orning; Helge Stormorken
Role of ADP and thromboxanes in human thrombus formation in ex vivo models.
Platelets 1997;8(6):385-90.
1996: Ross W Stephens; Lars Orning; Helge Stormorken; MJ Hamers; L B Petersen; Kjell S Sakariassen
Characterisation of cell-surface procoagulant activities using a microcarrier model.
Thrombosis research 1996;84(6):453-61.
1996: RM Barstad; M S Buchmann; MJ Hamers; Lars Orning; Una Orvim; Helge Stormorken; Kjell S Sakariassen
Effects of ionic and nonionic contrast media on endothelium and on arterial thrombus formation.
Acta radiologica (Stockholm, Sweden : 1987) 1996;37(6):954-61.
1996: Una Orvim; RM Barstad; Helge Stormorken; Frank Brosstad; Kjell S Sakariassen
Immunologic quantification of fibrin deposition in thrombi formed in flowing native human blood.
British journal of haematology 1996;95(2):389-98.
1996: H F Rønning; U C Risøen; Lars Orning; Knut Sletten; Kjell S Sakariassen
Synthetic peptide analogs of tissue factor and factor VII which inhibit factor Xa formation by the tissue factor/factor VIIa complex.
Thrombosis research 1996;84(2):73-81.
1996: RM Barstad; Eivind Ovrum; M A Ringdal; Rolf Oystese; MJ Hamers; O P Veiby; T Rolfsen; Ross W Stephens; Kjell S Sakariassen
Induction of monocyte tissue factor procoagulant activity during coronary artery bypass surgery is reduced with heparin-coated extracorporeal circuit.
British journal of haematology 1996;94(3):517-25.
1996: RM Barstad; Una Orvim; MJ Hamers; Geir Tjønnfjord; Frank Brosstad; Kjell S Sakariassen
Reduced effect of aspirin on thrombus formation at high shear and disturbed laminar blood flow.
Thrombosis and haemostasis 1996;75(5):827-32.
1996: RM Barstad; P Kierulf; Kjell S Sakariassen
Collagen induced thrombus formation at the apex of eccentric stenoses--a time course study with non-anticoagulated human blood.
Thrombosis and haemostasis 1996;75(4):685-92.
1995: Una Orvim; RM Barstad; G P Vlasuk; Kjell S Sakariassen
Effect of selective factor Xa inhibition on arterial thrombus formation triggered by tissue factor/factor VIIa or collagen in an ex vivo model of shear-dependent human thrombogenesis.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(12):2188-94.
1995: Armelle Diquélou; Dominique Dupouy; R Cariou; Kjell S Sakariassen; Bernard Boneu; Yves Cadroy
A comparative study of the anticoagulant and anti-thrombotic effects of unfractionated heparin and a low molecular weight heparin (Fraxiparine) in an experimental model of human venous thrombosis.
Thrombosis and haemostasis 1995;74(5):1286-92.
1995: Armelle Diquélou; Dominique Dupouy; D Gaspin; J Constans; Pierre Sié; Bernard Boneu; Kjell S Sakariassen; Yves Cadroy
Relationship between endothelial tissue factor and thrombogenesis under blood flow conditions.
Thrombosis and haemostasis 1995;74(2):778-83.
1995: RM Barstad; H E Roald; L B Petersen; K T Stokke; P Kierulf; Kjell S Sakariassen
Dietary supplement of omega-3 fatty acids has no effect on acute collagen-induced thrombus formation in flowing native blood.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1995;6(5):374-81.
1995: RM Barstad; MJ Hamers; Ross W Stephens; Kjell S Sakariassen
Retinoic acid reduces induction of monocyte tissue factor and tissue factor/factor VIIa-dependent arterial thrombus formation.
Blood 1995;86(1):212-8.
1995: H E Roald; Torstein Lyberg; H Dedichen; MJ Hamers; P Kierulf; A B Westvik; Kjell S Sakariassen
Collagen-induced thrombus formation in flowing nonanticoagulated human blood from habitual smokers and nonsmoking patients with severe peripheral atherosclerotic disease.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(1):128-32.
1995: RM Barstad; MJ Hamers; P Kierulf; A B Westvik; Kjell S Sakariassen
Procoagulant human monocytes mediate tissue factor/factor VIIa-dependent platelet-thrombus formation when exposed to flowing nonanticoagulated human blood.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(1):11-6.
1995: H E Roald; Kjell S Sakariassen
Axial dependence of collagen-induced thrombus formation in flowing non-anticoagulated human blood. Anti-platelet drugs impair thrombus growth and increase platelet-collagen adhesion.
Thrombosis and haemostasis 1995;73(1):126-31.
1994: RM Barstad; H E Roald; Y Cui; V T Turitto; Kjell S Sakariassen
A perfusion chamber developed to investigate thrombus formation and shear profiles in flowing native human blood at the apex of well-defined stenoses.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(12):1984-91.
1994: Una Orvim; H E Roald; Ross W Stephens; N Roos; Kjell S Sakariassen
Tissue factor-induced coagulation triggers platelet thrombus formation as efficiently as fibrillar collagen at arterial blood flow conditions.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(12):1976-83.
1994: RM Barstad; Helge Stormorken; Lars Orning; Ross W Stephens; L B Petersen; P Kierulf; Kjell S Sakariassen
Reduced thrombus formation in native blood of homozygous factor VII-deficient patients at high arterial wall shear rate.
Blood 1994;84(10):3371-7.
1994: P V Syversen; U Saeter; L Cunha-Ribeiro; Una Orvim; Knut Sletten; Gunnar Husby; Kjell S Sakariassen
The effect of serum amyloid protein A fragment-SAA25-76 on blood platelet aggregation.
Thrombosis research 1994;76(3):299-305.
1994: Armelle Diquélou; S Lemozy; Dominique Dupouy; Bernard Boneu; Kjell S Sakariassen; Yves Cadroy
Effect of blood flow on thrombin generation is dependent on the nature of the thrombogenic surface.
Blood 1994;84(7):2206-13.
1994: J A Salatti; J Fenton; P Anton; Kjell S Sakariassen
alpha-thrombin bound to extracellular endothelial matrix induces pronounced fibrin deposition and platelet thrombus growth in flowing non-anticoagulated human blood.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(4):561-6.
1994: H E Roald; RM Barstad; Inger Johanne Bakken; B Roald; Torstein Lyberg; Kjell S Sakariassen
Initial interactions of platelets and plasma proteins in flowing non-anticoagulated human blood with the artificial surfaces Dacron and PTFE.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1994;5(3):355-63.
1994: H E Roald; RM Barstad; P Kierulf; F Skjørten; JP Dickinson; G Kieffer; Kjell S Sakariassen
Clopidogrel--a platelet inhibitor which inhibits thrombogenesis in non-anticoagulated human blood independently of the blood flow conditions.
Thrombosis and haemostasis 1994;71(5):655-62.
1994: H E Roald; Una Orvim; Inger Johanne Bakken; RM Barstad; P Kierulf; Kjell S Sakariassen
Modulation of thrombotic responses in moderately stenosed arteries by cigarette smoking and aspirin ingestion.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(4):617-21.
1994: H E Roald; RM Barstad; A Engen; P Kierulf; F Skjørten; Kjell S Sakariassen
HN-11500--a novel thromboxane A2 receptor antagonist with antithrombotic activity in humans at arterial blood flow conditions.
Thrombosis and haemostasis 1994;71(1):103-9.
1993: J A Salatti; P Anton; Y Nemerson; Kjell S Sakariassen
Modulation of procoagulant activity of extracellular endothelial matrix by anti-tissue factor antibody and the synthetic peptide Arg-Gly-Asp-Val. Experiments with flowing non-anticoagulated human blood.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(6):881-90.
1993: Yves Cadroy; S Lemozy; Armelle Diquélou; J Ferrières; P Douste-Blazy; Bernard Boneu; Kjell S Sakariassen
Human type II hyperlipoproteinemia enhances platelet-collagen adhesion in flowing nonanticoagulated blood.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(11):1650-3.
1993: Kjell S Sakariassen; RM Barstad
Mechanisms of thromboembolism at arterial plaques.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(4):615-25.