FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Kirsty McLean

Research Profile

Chemicals & Drugs

Living Beings

Mycobacterium tuberculosis

Concepts & Ideas

Phenomena

Procedures

Spectrophotometry

Physiology

Electron Transport

Co-author Network

Publications

TOP 3
Andrew W Munro; Adrian J Dunford; Hazel M Girvan; Amy E Mason; Kirsty J McLean
What makes a P450 tick?
Hannah F Collins; Jorge C Escalante-Semerena; Michael Gray; Helen K Leech; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Rebekka Biedendieck; Andrew D Lawrence
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.
Kirsty J McLean; Marcus Hans; Andrew W Munro
Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Kirsty McLean (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Andrew W Munro; Adrian J Dunford; Hazel M Girvan; Amy E Mason; Kirsty J McLean
What makes a P450 tick?
Trends in biochemical sciences 2013;38(3):140-50.
2013: Hannah F Collins; Jorge C Escalante-Semerena; Michael Gray; Helen K Leech; Kirsty J McLean; Andrew W Munro; Stephen E J Rigby; Martin J Warren; Rebekka Biedendieck; Andrew D Lawrence
Bacillus megaterium has both a functional BluB protein required for DMB synthesis and a related flavoprotein that forms a stable radical species.
PloS one 2013;8(2):e55708.
2012: Kirsty J McLean; Marcus Hans; Andrew W Munro
Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.
Biochemical Society transactions 2012;40(3):587-93.
2012: Soi H Bui; Myles R Cheesman; Colin W Levy; David Leys; Kirsty J McLean; Justin M Bradley; Stephen E J Rigby; Andrew W Munro
Unusual spectroscopic and ligand binding properties of the cytochrome P450-flavodoxin fusion enzyme XplA.
The Journal of biological chemistry 2012;287(23):19699-714.
2012: Ashley J Warman; Martin J Warren; Andrew W Munro; Stephen E J Rigby; Jacob W Robinson; Myles R Cheesman; Andrew D Lawrence; Dominika Luciakova; Ker R Marshall; Kirsty J McLean
Characterization of Cupriavidus metallidurans CYP116B1--a thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein.
The FEBS journal 2012;279(9):1675-93.
2011: Caroline G Bowsher; L M Eyres; J O Gummadova; Parvinder Hothi; Kirsty J McLean; Andrew W Munro; Nigel S Scrutton; G T Hanke; Y Sakakibara; T Hase
Identification of N-terminal regions of wheat leaf ferredoxin NADP+ oxidoreductase important for interactions with ferredoxin.
Biochemistry 2011;50(11):1778-87.
2011: Max D Driscoll; Kirsty J McLean; Myles R Cheesman; Thomas A Jowitt; Marjorie Howard; Paul Carroll; Tanya Parish; Andrew W Munro
Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.
Biochimica et biophysica acta 2011;1814(1):76-87.
2010: Max D Driscoll; Kirsty J McLean; Colin Levy; Natalia Mast; Irina A Pikuleva; Pierre Lafite; Stephen E J Rigby; David Leys; Andrew W Munro
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
The Journal of biological chemistry 2010;285(49):38270-82.
2010: Kirsty J McLean; James Belcher; Max D Driscoll; Christine C Fernandez; Duyet Le Van; Soi Bui; Marina Golovanova; Andrew W Munro
The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
Future medicinal chemistry 2010;2(8):1339-53.
2009: Kirsty J McLean; Pierre Lafite; Colin Levy; Myles R Cheesman; Natalia Mast; Irina A Pikuleva; David Leys; Andrew W Munro
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
The Journal of biological chemistry 2009;284(51):35524-33.
2009: Muna Sabri; Adrian J Dunford; Kirsty J McLean; Rajasekhar Neeli; Nigel S Scrutton; David Leys; Andrew W Munro
Characterization of coenzyme binding and selectivity determinants in Mycobacterium tuberculosis flavoprotein reductase A: analysis of Arg(199) and Arg(200) mutants at the NADP(H) 2'-phosphate binding site.
The Biochemical journal 2009;417(1):103-12.
2008: Philip R Balding; Cristina S Porro; Kirsty J McLean; Michael J Sutcliffe; Jean-Didier Marechal; Andrew W Munro; Sam P de Visser
How do azoles inhibit cytochrome P450 enzymes? A density functional study.
The journal of physical chemistry. A 2008;112(50):12911-8.
2008: Kirsty J McLean; Paul Carroll; D Geraint Lewis; Adrian J Dunford; Harriet E Seward; Rajasekhar Neeli; Myles R Cheesman; Laurent Marsollier; Philip Douglas; W Ewen Smith; Ida Rosenkrands; Stewart T Cole; David Leys; Tanya Parish; Andrew W Munro
Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
The Journal of biological chemistry 2008;283(48):33406-16.
2008: Rajasekhar Neeli; Muna Sabri; Kirsty J McLean; Adrian J Dunford; Nigel S Scrutton; David Leys; Andrew W Munro
Trp(359) regulates flavin thermodynamics and coenzyme selectivity in Mycobacterium tuberculosis FprA.
The Biochemical journal 2008;411(3):563-70.
2008: Kirsty J McLean; Andrew W Munro
Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis.
Drug metabolism reviews 2008;40(3):427-46.
2007: Kirsty J McLean; Hazel M Girvan; Andrew W Munro
Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects.
Expert opinion on drug metabolism & toxicology 2007;3(6):847-63.
2007: Adrian J Dunford; Kirsty J McLean; Muna Sabri; Harriet E Seward; Derren J Heyes; Nigel S Scrutton; Andrew W Munro
Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
The Journal of biological chemistry 2007;282(34):24816-24.
2007: Kirsty J McLean; Adrian J Dunford; Rajasekhar Neeli; Max D Driscoll; Andrew W Munro
Structure, function and drug targeting in Mycobacterium tuberculosis cytochrome P450 systems.
Archives of biochemistry and biophysics 2007;464(2):228-40.
2007: Igor Efimov; Nektaria D Papadopoulou; Kirsty J McLean; Sandip K Badyal; Isabel K Macdonald; Andrew W Munro; Peter C E Moody; Emma Lloyd Raven
The redox properties of ascorbate peroxidase.
Biochemistry 2007;46(27):8017-23.
2007: Andrew W Munro; Hazel M Girvan; Kirsty J McLean
Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily.
Natural product reports 2007;24(3):585-609.
2007: Andrew W Munro; Hazel M Girvan; Kirsty J McLean
Cytochrome P450--redox partner fusion enzymes.
Biochimica et biophysica acta 2007;1770(3):345-59.
2006: Harriet E Seward; Anna Roujeinikova; Kirsty J McLean; Andrew W Munro; David Leys
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.
The Journal of biological chemistry 2006;281(51):39437-43.
2006: Kirsty J McLean; Adrian J Dunford; Muna Sabri; Rajasekhar Neeli; Hazel M Girvan; Philip R Balding; David Leys; Harriet E Seward; Ker R Marshall; Andrew W Munro
CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.
Biochemical Society transactions 2006;34(Pt 6):1178-82.
2006: Hazel M Girvan; T N Waltham; Rajasekhar Neeli; H F Collins; Kirsty J McLean; Nigel S Scrutton; David Leys; Andrew W Munro
Flavocytochrome P450 BM3 and the origin of CYP102 fusion species.
Biochemical Society transactions 2006;34(Pt 6):1173-7.
2006: Kirsty J McLean; Ashley J Warman; Harriet E Seward; Ker R Marshall; Hazel M Girvan; Myles R Cheesman; Michael R Waterman; Andrew W Munro
Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
Biochemistry 2006;45(27):8427-43.
2006: Kirsty J McLean; Daniel Clift; D Geraint Lewis; Muna Sabri; Philip R Balding; Michael J Sutcliffe; David Leys; Andrew W Munro
The preponderance of P450s in the Mycobacterium tuberculosis genome.
Trends in microbiology 2006;14(5):220-8.
2005: Nektaria D Papadopoulou; Martin Mewies; Kirsty J McLean; Harriet E Seward; Dimitri A Svistunenko; Andrew W Munro; Emma Lloyd Raven
Redox and spectroscopic properties of human indoleamine 2,3-dioxygenase and a His303Ala variant: implications for catalysis.
Biochemistry 2005;44(43):14318-28.
2005: Kirsty J McLean; Muna Sabri; Ker R Marshall; Rachel J Lawson; D G Lewis; D Clift; Philip R Balding; Adrian J Dunford; Ashley J Warman; J P McVey; A-M Quinn; Michael J Sutcliffe; Nigel S Scrutton; Andrew W Munro
Biodiversity of cytochrome P450 redox systems.
Biochemical Society transactions 2005;33(Pt 4):796-801.
2005: Ashley J Warman; Olivier Roitel; Rajasekhar Neeli; Hazel M Girvan; Harriet E Seward; S A Murray; Kirsty J McLean; M Gordon Joyce; Helen S Toogood; R A Holt; David Leys; Nigel S Scrutton; Andrew W Munro
Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme.
Biochemical Society transactions 2005;33(Pt 4):747-53.
2004: Luca Quaroni; Harriet E Seward; Kirsty J McLean; Hazel M Girvan; Tobias W B Ost; Michael A Noble; Sharon M Kelly; Nicholas C Price; Myles R Cheesman; W Ewen Smith; Andrew W Munro
Interaction of nitric oxide with cytochrome P450 BM3.
Biochemistry 2004;43(51):16416-31.
2003: Andrew W Munro; Kirsty J McLean; Ker R Marshall; Ashley J Warman; G Lewis; Olivier Roitel; Michael J Sutcliffe; Carol A Kemp; S Modi; Nigel S Scrutton; David Leys
Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis.
Biochemical Society transactions 2003;31(Pt 3):625-30.
2003: Kirsty J McLean; Nigel S Scrutton; Andrew W Munro
Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA.
The Biochemical journal 2003;372(Pt 2):317-27.
2003: David Leys; Christopher G Mowat; Kirsty J McLean; Alison Richmond; Stephen K Chapman; Malcolm D Walkinshaw; Andrew W Munro
Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.
The Journal of biological chemistry 2003;278(7):5141-7.
2002: Kirsty J McLean; Ker R Marshall; Alison Richmond; Iain S Hunter; Kay Fowler; Tobias Kieser; Sudagar S Gurcha; Gurdyal S Besra; Andrew W Munro
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
Microbiology (Reading, England) 2002;148(Pt 10):2937-49.
2002: Kirsty J McLean; Myles R Cheesman; Stuart L Rivers; Alison Richmond; David Leys; Stephen K Chapman; Graeme A Reid; Nicholas C Price; Sharon M Kelly; John Clarkson; W Ewen Smith; Andrew W Munro
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.
Journal of inorganic biochemistry 2002;91(4):527-41.
2002: Andrew W Munro; David G Leys; Kirsty J McLean; Ker R Marshall; Tobias W B Ost; Simon Daff; Caroline S Miles; Stephen K Chapman; Dominikus Lysek; Christopher C Moser; Christopher C Page; P Leslie Dutton
P450 BM3: the very model of a modern flavocytochrome.
Trends in biochemical sciences 2002;27(5):250-7.
2002: Christopher G Mowat; David Leys; Kirsty J McLean; Stuart L Rivers; Alison Richmond; Andrew W Munro; Miguel Ortiz Lombardia; Pedro Alzari; Graeme A Reid; Stephen K Chapman; Malcolm D Walkinshaw
Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 4):704-5.
2000: Andrew W Munro; Michael A Noble; Tobias W B Ost; A J Green; Kirsty J McLean; L Robledo; Caroline S Miles; J Murdoch; Stephen K Chapman
Flavocytochrome P450 BM3 substrate selectivity and electron transfer in a model cytochrome P450.
Sub-cellular biochemistry 2000;35():297-315.