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klaus podar
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87
Anderson, Kenneth
73
Hideshima, Teru
69
Chauhan, Dharminder
45
Munshi, Nikhil
38
Tai, Yu-Tzu
29
Mitsiades, Constantine
28
Richardson, Paul
27
Raje, Noopur
23
Catley, Laurence
19
Richardson, Paul
17
Ishitsuka, Kenji
15
Sattler, Martin
15
Schlossman, Robert
15
Yasui, Hiroshi
14
Mitsiades, Nicholas
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All Publications
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2009: Chauhan Dharminder; Singh Ajita V; Brahmandam Mohan; Carrasco Ruben; Bandi Madhavi; Hideshima Teru; Bianchi Giada; Podar Klaus; Tai Yu-Tzu; Mitsiades Constantine; Raje Noopur; Jaye David L; Kumar Shaji K; Richardson Paul; Munshi Nikhil; Anderson Kenneth C
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Cancer cell 2009;16(4):309-23.
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2009: Blotta Simona; Tassone Pierfrancesco; Prabhala Rao H; Tagliaferri Piersandro; Cervi David; Amin Samir; Jakubikova Jana; Tai Yu-Tzu; Podar Klaus; Mitsiades Constantine S; Zullo Alessandro; Franco Brunella; Anderson Kenneth C; Munshi Nikhil C
Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.
Blood 2009;114(15):3276-84.
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2009: Fernandes Margret S; Reddy Mamatha M; Gonneville Jeffrey R; DeRoo Scott C; Podar Klaus; Griffin James D; Weinstock David M; Sattler Martin
BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.
Blood 2009;114(9):1813-9.
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2009: Raab Marc S; Podar Klaus; Breitkreutz Iris; Richardson Paul G; Anderson Kenneth C
Multiple myeloma.
Lancet 2009;374(9686):324-39.
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2009: Hideshima Teru; Ikeda Hiroshi; Chauhan Dharminder; Okawa Yutaka; Raje Noopur; Podar Klaus; Mitsiades Constantine; Munshi Nikhil C; Richardson Paul G; Carrasco Ruben D; Anderson Kenneth C
Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Blood 2009;114(5):1046-52.
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2009: Hideshima Teru; Chauhan Dharminder; Kiziltepe Tanyel; Ikeda Hiroshi; Okawa Yutaka; Podar Klaus; Raje Noopur; Protopopov Alexei; Munshi Nikhil C; Richardson Paul G; Carrasco Ruben D; Anderson Kenneth C
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Blood 2009;113(21):5228-36.
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2009: Tai Yu-Tzu; Soydan Ender; Song Weihua; Fulciniti Mariateresa; Kim Kihyun; Hong Fangxin; Li Xian-Feng; Burger Peter; Rumizen Matthew J; Nahar Sabikun; Podar Klaus; Hideshima Teru; Munshi Nikhil C; Tonon Giovanni; Carrasco Ruben D; Afar Daniel E H; Anderson Kenneth C
CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.
Blood 2009;113(18):4309-18.
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2009: Podar Klaus; Tai Yu-Tzu; Hideshima Teru; Vallet Sonia; Richardson Paul G; Anderson Kenneth C
Emerging therapies for multiple myeloma.
Expert opinion on emerging drugs 2009;14(1):99-127.
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2009: Burger Renate; Le Gouill Steven; Tai Yu-Tzu; Shringarpure Reshma; Tassone Pierfrancesco; Neri Paola; Podar Klaus; Catley Laurence; Hideshima Teru; Chauhan Dharminder; Caulder Eian; Neilan Claire L; Vaddi Kris; Li Jun; Gramatzki Martin; Fridman Jordan S; Anderson Kenneth C
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.
Molecular cancer therapeutics 2009;8(1):26-35.
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2008: Tai Yu-Tzu; Dillon Myles; Song Weihua; Leiba Merav; Li Xian-Feng; Burger Peter; Lee Alfred I; Podar Klaus; Hideshima Teru; Rice Audie G; van Abbema Anne; Jesaitis Lynne; Caras Ingrid; Law Debbie; Weller Edie; Xie Wanling; Richardson Paul; Munshi Nikhil C; Mathiot Claire; Avet-Loiseau Hervé; Afar Daniel E H; Anderson Kenneth C
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
Blood 2008;112(4):1329-37.
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2008: Wernig Gerlinde; Gonneville Jeffrey R; Crowley Brian J; Rodrigues Margret S; Reddy Mamatha M; Hudon Heidi E; Walz Christoph; Reiter Andreas; Podar Klaus; Royer Yohan; Constantinescu Stefan N; Tomasson Michael H; Griffin James D; Gilliland D Gary; Sattler Martin
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Blood 2008;111(7):3751-9.
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2008: Chauhan Dharminder; Singh Ajita; Brahmandam Mohan; Podar Klaus; Hideshima Teru; Richardson Paul; Munshi Nikhil; Palladino Michael A; Anderson Kenneth C
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Blood 2008;111(3):1654-64.
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2008: Podar K; Gouill S L; Zhang J; Opferman J T; Zorn E; Tai Y-T; Hideshima T; Amiot M; Chauhan D; Harousseau J-L; Anderson K C
A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
Oncogene 2008;27(6):721-31.
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2007: Podar Klaus; Richardson Paul G; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
The malignant clone and the bone-marrow environment.
Best practice & research. Clinical haematology 2007;20(4):597-612.
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2007: Vallet Sonia; Raje Noopur; Ishitsuka Kenji; Hideshima Teru; Podar Klaus; Chhetri Shweta; Pozzi Samantha; Breitkreutz Iris; Kiziltepe Tanyel; Yasui Hiroshi; Ocio Enrique M; Shiraishi Norihiko; Jin Janice; Okawa Yutaka; Ikeda Hiroshi; Mukherjee Siddhartha; Vaghela Nileshwari; Cirstea Diana; Ladetto Marco; Boccadoro Mario; Anderson Kenneth C
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.
Blood 2007;110(10):3744-52.
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2007: Podar Klaus; Raab Marc S; Chauhan Dharminder; Anderson Kenneth C
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Expert opinion on investigational drugs 2007;16(10):1693-707.
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2007: Hideshima Teru; Catley Laurence; Raje Noopur; Chauhan Dharminder; Podar Klaus; Mitsiades Constantine; Tai Yu-Tzu; Vallet Sonia; Kiziltepe Tanyel; Ocio Enrique; Ikeda Hiroshi; Okawa Yutaka; Hideshima Hiromasa; Munshi Nikhil C; Yasui Hiroshi; Richardson Paul G; Anderson Kenneth C
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
British journal of haematology 2007;138(6):783-91.
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2007: Tai Yu-Tzu; Fulciniti Mariateresa; Hideshima Teru; Song Weihua; Leiba Merav; Li Xian-Feng; Rumizen Matthew; Burger Peter; Morrison Aileen; Podar Klaus; Chauhan Dharminder; Tassone Pierfrancesco; Richardson Paul; Munshi Nikhil C; Ghobrial Irene M; Anderson Kenneth C
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Blood 2007;110(5):1656-63.
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2007: Moreau Anne-Sophie; Jia Xiaoying; Ngo Hai T; Leleu Xavier; O'Sullivan Garrett; Alsayed Yazan; Leontovich Alexey; Podar Klaus; Kutok Jeffrey; Daley John; Lazo-Kallanian Suzan; Hatjiharissi Evdoxia; Raab Marc S; Xu Lian; Treon Steven P; Hideshima Teru; Anderson Kenneth C; Ghobrial Irene M
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
Blood 2007;109(11):4964-72.
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2007: Podar Klaus; Richardson Paul G; Chauhan Dharminder; Anderson Kenneth C
Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma.
Expert review of anticancer therapy 2007;7(4):551-66.
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2007: Chauhan D; Velankar M; Brahmandam M; Hideshima T; Podar K; Richardson P; Schlossman R; Ghobrial I; Raje N; Munshi N; Anderson K C
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Oncogene 2007;26(16):2374-80.
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2007: Podar Klaus; Anderson Kenneth C
Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies.
Cell cycle (Georgetown, Tex.) 2007;6(5):538-42.
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2007: Yasui H; Hideshima T; Ikeda H; Ocio E M; Kiziltepe T; Vallet S; Okawa Y; Neri P; Sukhdeo K; Podar K; Chauhan D; Richardson P G; Raje N; Carrasco D R; Anderson K C
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of beta-catenin/TCF pathway.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(3):535-40.
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2007: Podar Klaus; Raab Marc S; Tonon Giovanni; Sattler Martin; Barilà Daniela; Zhang Jing; Tai Yu-Tzu; Yasui Hiroshi; Raje Noopur; DePinho Ronald A; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
Cancer research 2007;67(4):1680-8.
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2007: Yasui Hiroshi; Hideshima Teru; Ikeda Hiroshi; Jin Janice; Ocio Enrique M; Kiziltepe Tanyel; Okawa Yutaka; Vallet Sonia; Podar Klaus; Ishitsuka Kenji; Richardson Paul G; Pargellis Chris; Moss Neil; Raje Noopur; Anderson Kenneth C
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth.
British journal of haematology 2007;136(3):414-23.
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2007: Chauhan Dharminder; Neri Paola; Velankar Mugdha; Podar Klaus; Hideshima Teru; Fulciniti Mariateresa; Tassone Pierfrancesco; Raje Noopur; Mitsiades Constantine; Mitsiades Nicholas; Richardson Paul; Zawel Leigh; Tran Mary; Munshi Nikhil; Anderson Kenneth C
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
Blood 2007;109(3):1220-7.
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2007: Podar Klaus; Raab Marc S; Zhang Jing; McMillin Douglas; Breitkreutz Iris; Tai Yu-Tzu; Lin Boris K; Munshi Nikhil; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Blood 2007;109(4):1669-77.
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2007: Podar Klaus; Raje Noopur; Anderson Kenneth C
Inhibition of the TGF-beta signaling pathway in tumor cells.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;172():77-97.
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2006: Podar Klaus; Tonon Giovanni; Sattler Martin; Tai Yu-Tzu; Legouill Steven; Yasui Hiroshi; Ishitsuka Kenji; Kumar Shaji; Kumar Rakesh; Pandite Lini N; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19478-83.
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2006: Weisberg Ellen; Wright Renee D; Jiang Jingrui; Ray Arghya; Moreno Daisy; Manley Paul W; Fabbro Doriano; Hall-Meyers Elizabeth; Catley Laurie; Podar Klaus; Kung Andrew L; Griffin James D
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
Gastroenterology 2006;131(6):1734-42.
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2006: Hideshima Teru; Neri Paola; Tassone Pierfranchesco; Yasui Hiroshi; Ishitsuka Kenji; Raje Noopur; Chauhan Dharminder; Podar Klaus; Mitsiades Constantine; Dang Lenny; Munshi Nikhil; Richardson Paul; Schenkein David; Anderson Kenneth C
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5887-94.
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2006: Shringarpure Reshma; Catley Laurence; Bhole Deepak; Burger Renate; Podar Klaus; Tai Yu-Tzu; Kessler Benedikt; Galardy Paul; Ploegh Hidde; Tassone Pierfrancesco; Hideshima Teru; Mitsiades Constantine; Munshi Nikhil C; Chauhan Dharminder; Anderson Kenneth C
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
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2006: Tai Yu-Tzu; Li Xian-Feng; Breitkreutz Iris; Song Weihua; Neri Paola; Catley Laurence; Podar Klaus; Hideshima Teru; Chauhan Dharminder; Raje Noopur; Schlossman Robert; Richardson Paul; Munshi Nikhil C; Anderson Kenneth C
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2006;66(13):6675-82.
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2006: Walz Christoph; Crowley Brian J; Hudon Heidi E; Gramlich Jessica L; Neuberg Donna S; Podar Klaus; Griffin James D; Sattler Martin
Activated Jak2 with the V617F point mutation promotes G1/S phase transition.
The Journal of biological chemistry 2006;281(26):18177-83.
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2006: Hideshima Teru; Catley Laurence; Yasui Hiroshi; Ishitsuka Kenji; Raje Noopur; Mitsiades Constantine; Podar Klaus; Munshi Nikhil C; Chauhan Dharminder; Richardson Paul G; Anderson Kenneth C
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Blood 2006;107(10):4053-62.
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2006: Kumar Shaji; Raje Noopur; Hideshima Teru; Ishitsuka Kenji; Podar Klaus; Le Gouille Steven; Chauhan Dharminder; Richardson Paul; Munshi Nikhil C; Anderson Kenneth
FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma.
British journal of haematology 2006;132(6):698-704.
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2006: Podar Klaus; Anderson Kenneth C
Caveolin-1 as a potential new therapeutic target in multiple myeloma.
Cancer letters 2006;233(1):10-5.
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2005: Tai Yu-Tzu; Li Xian-Feng; Catley Laurence; Coffey Rory; Breitkreutz Iris; Bae Jooeun; Song Weihua; Podar Klaus; Hideshima Teru; Chauhan Dharminder; Schlossman Robert; Richardson Paul; Treon Steven P; Grewal Iqbal S; Munshi Nikhil C; Anderson Kenneth C
Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Cancer research 2005;65(24):11712-20.
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2005: Chauhan Dharminder; Catley Laurence; Li Guilan; Podar Klaus; Hideshima Teru; Velankar Mugdha; Mitsiades Constantine; Mitsiades Nicolas; Yasui Hiroshi; Letai Anthony; Ovaa Huib; Berkers Celia; Nicholson Benjamin; Chao Ta-Hsiang; Neuteboom Saskia T C; Richardson Paul; Palladino Michael A; Anderson Kenneth C
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Cancer cell 2005;8(5):407-19.
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2005: Chauhan Dharminder; Li Guilan; Podar Klaus; Hideshima Teru; Neri Paola; He Deli; Mitsiades Nicholas; Richardson Paul; Chang Yan; Schindler Joanne; Carver Bradley; Anderson Kenneth C
A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells.
Cancer research 2005;65(18):8350-8.
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2005: Ishitsuka Kenji; Hideshima Teru; Hamasaki Makoto; Raje Noopur; Kumar Shaji; Podar Klaus; Le Gouill Steven; Shiraishi Norihiko; Yasui Hiroshi; Roccaro Aldo M; Tai Yu-Zu; Chauhan Dharminder; Fram Robert; Tamura Kazuo; Jain Jugnu; Anderson Kenneth C
Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway.
Oncogene 2005;24(38):5888-96.
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2005: Ishitsuka Kenji; Hideshima Teru; Hamasaki Makoto; Raje Noopur; Kumar Shaji; Hideshima Hiromasa; Shiraishi Norihiko; Yasui Hiroshi; Roccaro Aldo M; Richardson Paul; Podar Klaus; Le Gouill Steven; Chauhan Dharminder; Tamura Kazuo; Arbiser Jack; Anderson Kenneth C
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
Blood 2005;106(5):1794-800.
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2005: Yasui Hiroshi; Hideshima Teru; Raje Noopur; Roccaro Aldo M; Shiraishi Norihiko; Kumar Shaji; Hamasaki Makoto; Ishitsuka Kenji; Tai Yu-Tzu; Podar Klaus; Catley Laurence; Mitsiades Constantine S; Richardson Paul G; Albert Rainer; Brinkmann Volker; Chauhan Dharminder; Anderson Kenneth C
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Cancer research 2005;65(16):7478-84.
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2005: Tai Yu-Tzu; Li Xianfeng; Tong Xia; Santos Daniel; Otsuki Takemi; Catley Laurence; Tournilhac Olivier; Podar Klaus; Hideshima Teru; Schlossman Robert; Richardson Paul; Munshi Nikhil C; Luqman Mohammad; Anderson Kenneth C
Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma.
Cancer research 2005;65(13):5898-906.
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2005: Yasui Hiroshi; Hideshima Teru; Hamasaki Makoto; Roccaro Aldo M; Shiraishi Norihiko; Kumar Shaji; Tassone Pierfrancesco; Ishitsuka Kenji; Raje Noopur; Tai Yu-Tzu; Podar Klaus; Chauhan Dharminder; Leoni Lorenzo M; Kanekal Sarath; Elliott Gary; Munshi Nikhil C; Anderson Kenneth C
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Blood 2005;106(2):706-12.
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2005: Tassone Pierfrancesco; Neri Paola; Burger Renate; Savino Rocco; Shammas Masood; Catley Laurence; Podar Klaus; Chauhan Dharminder; Masciari Serena; Gozzini Antonella; Tagliaferri Pierosandro; Venuta Salvatore; Munshi Nikhil C; Anderson Kenneth C
Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4251-8.
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2005: Podar Klaus; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Targeting signalling pathways for the treatment of multiple myeloma.
Expert opinion on therapeutic targets 2005;9(2):359-81.
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2005: Hideshima Teru; Chauhan Dharminder; Ishitsuka Kenji; Yasui Hiroshi; Raje Noopur; Kumar Shaji; Podar Klaus; Mitsiades Constantine; Hideshima Hiromasa; Bonham Lynn; Munshi Nikhil C; Richardson Paul G; Singer Jack W; Anderson Kenneth C
Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Oncogene 2005;24(19):3121-9.
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2005: Kim Jeong H; Chu Stephanie C; Gramlich Jessica L; Pride Yuri B; Babendreier Emily; Chauhan Dharminder; Salgia Ravi; Podar Klaus; Griffin James D; Sattler Martin
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Blood 2005;105(4):1717-23.
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2005: Podar Klaus; Anderson Kenneth C
The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications.
Blood 2005;105(4):1383-95.
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2005: Hayashi Toshiaki; Hideshima Teru; Akiyama Masaharu; Podar Klaus; Yasui Hiroshi; Raje Noopur; Kumar Shaji; Chauhan Dharminder; Treon Steven P; Richardson Paul; Anderson Kenneth C
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application.
British journal of haematology 2005;128(2):192-203.
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2005: Lin Boris; Catley Laurence; LeBlanc Richard; Mitsiades Constantine; Burger Renate; Tai Yu-Tzu; Podar Klaus; Wartmann Markus; Chauhan Dharminder; Griffin James D; Anderson Kenneth C
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
Blood 2005;105(1):350-7.
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2005: Hideshima Teru; Podar Klaus; Chauhan Dharminder; Anderson Kenneth C
Cytokines and signal transduction.
Best practice & research. Clinical haematology 2005;18(4):509-24.
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2004: Catley Laurence; Tai Yu-Tzu; Shringarpure Reshma; Burger Renate; Son Moni Thi; Podar Klaus; Tassone Pierfrancesco; Chauhan Dharminder; Hideshima Teru; Denis Louis; Richardson Paul; Munshi Nikhil C; Anderson Kenneth C
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Cancer research 2004;64(23):8746-53.
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2004: Raje Noopur; Kumar Shaji; Hideshima Teru; Ishitsuka Kenji; Chauhan Dharminder; Mitsiades Constantine; Podar Klaus; Le Gouill Steven; Richardson Paul; Munshi Nikhil C; Stirling David I; Antin Joseph H; Anderson Kenneth C
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Blood 2004;104(13):4188-93.
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2004: Hayashi Toshiaki; Hideshima Teru; Nguyen Aaron N; Munoz Olivier; Podar Klaus; Hamasaki Makoto; Ishitsuka Kenji; Yasui Hiroshi; Richardson Paul; Chakravarty Sarvajit; Murphy Alison; Chauhan Dharminder; Higgins Linda S; Anderson Kenneth C
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7540-6.
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2004: Hideshima Teru; Podar Klaus; Chauhan Dharminder; Ishitsuka Kenji; Mitsiades Constantine; Tai Yu-Tzu; Hamasaki Makoto; Raje Noopur; Hideshima Hiromasa; Schreiner George; Nguyen Aaron N; Navas Tony; Munshi Nikhil C; Richardson Paul G; Higgins Linda S; Anderson Kenneth C
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Oncogene 2004;23(54):8766-76.
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2004: Le Gouill Steven; Podar Klaus; Amiot Martine; Hideshima Teru; Chauhan Dharminder; Ishitsuka Kenji; Kumar Shaji; Raje Noopur; Richardson Paul G; Harousseau Jean-Luc; Anderson Kenneth C
VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis.
Blood 2004;104(9):2886-92.
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2004: Podar Klaus; Shringarpure Reshma; Tai Yu-Tzu; Simoncini Melissa; Sattler Martin; Ishitsuka Kenji; Richardson Paul G; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
Cancer research 2004;64(20):7500-6.
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2004: Le Gouill Steven; Podar Klaus; Harousseau Jean-Luc; Anderson Kenneth C
Mcl-1 regulation and its role in multiple myeloma.
Cell cycle (Georgetown, Tex.) 2004;3(10):1259-62.
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2004: Chauhan Dharminder; Li Guilan; Podar Klaus; Hideshima Teru; Mitsiades Constantine; Schlossman Robert; Munshi Nikhil; Richardson Paul; Cotter Finbarr E; Anderson Kenneth C
Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Blood 2004;104(8):2458-66.
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2004: Podar Klaus; Mostoslavsky Gustavo; Sattler Martin; Tai Yu-Tzu; Hayashi Toshiaki; Catley Laurence P; Hideshima Teru; Mulligan Richard C; Chauhan Dharminder; Anderson Kenneth C
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
The Journal of biological chemistry 2004;279(20):21658-65.
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2004: Podar Klaus; Catley Laurence P; Tai Yu-Tzu; Shringarpure Reshma; Carvalho Pedro; Hayashi Toshiaki; Burger Renate; Schlossman Robert L; Richardson Paul G; Pandite Lini N; Kumar Rakesh; Hideshima Teru; Chauhan Dharminder; Anderson Kenneth C
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Blood 2004;103(9):3474-9.
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2004: Chauhan Dharminder; Li Guilan; Hideshima Teru; Podar Klaus; Shringarpure Reshma; Mitsiades Constantine; Munshi Nikhil; Yew P Renee; Anderson Kenneth C
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Oncogene 2004;23(20):3597-602.
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2004: Tai Yu-Tzu; Catley Laurence P; Mitsiades Constantine S; Burger Renate; Podar Klaus; Shringpaure Reshma; Hideshima Teru; Chauhan Dharminder; Hamasaki Makoto; Ishitsuka Kenji; Richardson Paul; Treon Steven P; Munshi Nikhil C; Anderson Kenneth C
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Cancer research 2004;64(8):2846-52.
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2004: Chauhan Dharminder; Li Guilan; Podar Klaus; Hideshima Teru; Shringarpure Reshma; Catley Laurence; Mitsiades Constantine; Munshi Nikhil; Tai Yu Tzu; Suh Nanjoo; Gribble Gordon W; Honda Tadashi; Schlossman Robert; Richardson Paul; Sporn Michael B; Anderson Kenneth C
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Blood 2004;103(8):3158-66.
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2004: Chauhan D; Li G; Auclair D; Hideshima T; Podar K; Mitsiades N; Mitsiades C; Chen L B; Munshi N; Saxena S; Anderson K C
2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Apoptosis : an international journal on programmed cell death 2004;9(2):149-55.
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2003: Hideshima Teru; Chauhan Dharminder; Hayashi Toshiaki; Podar Klaus; Akiyama Masaharu; Mitsiades Constantine; MItsiades Nicholas; Gong Baoqing; Bonham Lynn; de Vries Peter; Munshi Nikhil; Richardson Paul G; Singer Jack W; Anderson Kenneth C
Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Cancer research 2003;63(23):8428-36.
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2003: Hideshima Teru; Chauhan Dharminder; Hayashi Toshiaki; Akiyama Masaharu; Mitsiades Nicholas; Mitsiades Constantine; Podar Klaus; Munshi Nikhil C; Richardson Paul G; Anderson Kenneth C
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma.
Oncogene 2003;22(52):8386-93.
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2003: Chauhan Dharminder; Li Guilan; Hideshima Teru; Podar Klaus; Mitsiades Constantine; Mitsiades Nicholas; Catley Laurence; Tai Yu Tzu; Hayashi Toshiaki; Shringarpure Reshma; Burger Renate; Munshi Nikhil; Ohtake Yasuyuki; Saxena Satya; Anderson Kenneth C
Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Blood 2003;102(9):3379-86.
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2003: Chauhan Dharminder; Li Guilan; Shringarpure Reshma; Podar Klaus; Ohtake Yasuyuki; Hideshima Teru; Anderson Kenneth C
Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.
Cancer research 2003;63(19):6174-7.
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2003: Tai Yu-Tzu; Podar Klaus; Catley Laurence; Tseng Yu-Hua; Akiyama Masaharu; Shringarpure Reshma; Burger Renate; Hideshima Teru; Chauhan Dharminder; Mitsiades Nicholas; Richardson Paul; Munshi Nikhil C; Kahn C Ronald; Mitsiades Constantine; Anderson Kenneth C
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
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2003: Sattler Martin; Pride Yuri B; Ma Patrick; Gramlich Jessica L; Chu Stephanie C; Quinnan Laura A; Shirazian Sheri; Liang Congxin; Podar Klaus; Christensen James G; Salgia Ravi
A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
Cancer research 2003;63(17):5462-9.
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2003: Chauhan Dharminder; Li Guilan; Sattler Martin; Podar Klaus; Mitsiades Constantine; Mitsiades Nicholas; Munshi Nikhil; Hideshima Teru; Anderson Kenneth C
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Oncogene 2003;22(40):6296-300.
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2003: Chauhan Dharminder; Li Guilan; Hideshima Teru; Podar Klaus; Mitsiades Constantine; Mitsiades Nicholas; Munshi Nikhil; Kharbanda Surender; Anderson Kenneth C
JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
The Journal of biological chemistry 2003;278(20):17593-6.
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2003: Chauhan Dharminder; Li Guilan; Auclair Daniel; Hideshima Teru; Richardson Paul; Podar Klaus; Mitsiades Nicholas; Mitsiades Constantine; Li Cheng; Kim Ryung Suk; Munshi Nikhil; Chen Lan Bo; Wong Wing; Anderson Kenneth C
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Blood 2003;101(9):3606-14.
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2003: Tai Yu-Tzu; Podar Klaus; Mitsiades Nicholas; Lin Boris; Mitsiades Constantine; Gupta Deepak; Akiyama Masaharu; Catley Laurence; Hideshima Teru; Munshi Nikhil C; Treon Steven P; Anderson Kenneth C
CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Blood 2003;101(7):2762-9.
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2003: Podar Klaus; Tai Yu-Tzu; Cole Craig E; Hideshima Teru; Sattler Martin; Hamblin Angela; Mitsiades Nicholas; Schlossman Robert L; Davies Faith E; Morgan Gareth J; Munshi Nikhil C; Chauhan Dharminder; Anderson Kenneth C
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
The Journal of biological chemistry 2003;278(8):5794-801.
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2003: Hideshima Teru; Mitsiades Constantine; Akiyama Masaharu; Hayashi Toshiaki; Chauhan Dharminder; Richardson Paul; Schlossman Robert; Podar Klaus; Munshi Nikhil C; Mitsiades Nicholas; Anderson Kenneth C
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Blood 2003;101(4):1530-4.
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2003: Lentzsch S; LeBlanc R; Podar K; Davies F; Lin B; Hideshima T; Catley L; Stirling D I; Anderson K C
Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(1):41-4.
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2002: Lin Boris; Podar Klaus; Gupta Deepak; Tai Yu-Tzu; Li Sigui; Weller Edie; Hideshima Teru; Lentzsch Suzanne; Davies Faith; Li Cheng; Weisberg Ellen; Schlossman Robert L; Richardson Paul G; Griffin James D; Wood Jeanette; Munshi Nikhil C; Anderson Kenneth C
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2002;62(17):5019-26.
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2002: Chauhan Dharminder; Catley Laurence; Hideshima Teru; Li Guilan; Leblanc Richard; Gupta Deepak; Sattler Martin; Richardson Paul; Schlossman Robert L; Podar Klaus; Weller Edie; Munshi Nikhil; Anderson Kenneth C
2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Blood 2002;100(6):2187-94.
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2002: Gupta Deepak; Podar Klaus; Tai Yu Tzu; Lin Boris; Hideshima Teru; Akiyama Masaharu; LeBlanc Richard; Catley Laurence; Mitsiades Nicholas; Mitsiades Constantine; Chauhan Dharminder; Munshi Nikhil C; Anderson Kenneth C
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Experimental hematology 2002;30(7):711-20.
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2002: Sattler Martin; Mohi M Golam; Pride Yuri B; Quinnan Laura R; Malouf Nicole A; Podar Klaus; Gesbert Franck; Iwasaki Hiromi; Li Shaoguang; Van Etten Richard A; Gu Haihua; Griffin James D; Neel Benjamin G
Critical role for Gab2 in transformation by BCR/ABL.
Cancer cell 2002;1(5):479-92.
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2002: Hideshima Teru; Chauhan Dharminder; Hayashi Toshiaki; Podar Klaus; Akiyama Masaharu; Gupta Deepak; Richardson Paul; Munshi Nikhil; Anderson Kenneth C
The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
Molecular cancer therapeutics 2002;1(7):539-44.
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2002: Tai Yu-Tzu; Podar Klaus; Kraeft Stine-Kathrein; Wang Fengfei; Young Gloria; Lin Boris; Gupta Deepak; Chen Lan Bo; Anderson Kenneth C
Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications.
Experimental hematology 2002;30(3):212-20.
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2002: Kubicek Markus; Pacher Margit; Abraham Dietmar; Podar Klaus; Eulitz Manfred; Baccarini Manuela
Dephosphorylation of Ser-259 regulates Raf-1 membrane association.
The Journal of biological chemistry 2002;277(10):7913-9.
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2002: Podar Klaus; Tai Yu-Tzu; Lin Boris K; Narsimhan Radha P; Sattler Martin; Kijima Takashi; Salgia Ravi; Gupta Deepak; Chauhan Dharminder; Anderson Kenneth C
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
The Journal of biological chemistry 2002;277(10):7875-81.
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2002: Chauhan Dharminder; Auclair Daniel; Robinson Elisabeth K; Hideshima Teru; Li Guilan; Podar Klaus; Gupta Deepak; Richardson Paul; Schlossman Robert L; Krett Nancy; Chen Lan Bo; Munshi Nikhil C; Anderson Kenneth C
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
Oncogene 2002;21(9):1346-58.
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2002: Tai Yu-Tzu; Podar Klaus; Gupta Deepak; Lin Boris; Young Gloria; Akiyama Masaharu; Anderson Kenneth C
CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells.
Blood 2002;99(4):1419-27.
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2001: Gupta D; Treon S P; Shima Y; Hideshima T; Podar K; Tai Y T; Lin B; Lentzsch S; Davies F E; Chauhan D; Schlossman R L; Richardson P; Ralph P; Wu L; Payvandi F; Muller G; Stirling D I; Anderson K C
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(12):1950-61.
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2001: Hideshima T; Chauhan D; Podar K; Schlossman R L; Richardson P; Anderson K C
Novel therapies targeting the myeloma cell and its bone marrow microenvironment.
Seminars in oncology 2001;28(6):607-12.
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2001: Podar K; Tai Y T; Davies F E; Lentzsch S; Sattler M; Hideshima T; Lin B K; Gupta D; Shima Y; Chauhan D; Mitsiades C; Raje N; Richardson P; Anderson K C
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Blood 2001;98(2):428-35.
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2001: Davies F E; Raje N; Hideshima T; Lentzsch S; Young G; Tai Y T; Lin B; Podar K; Gupta D; Chauhan D; Treon S P; Richardson P G; Schlossman R L; Morgan G J; Muller G W; Stirling D I; Anderson K C
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Blood 2001;98(1):210-6.
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2000: Tai Y T; Teoh G; Lin B; Davies F E; Chauhan D; Treon S P; Raje N; Hideshima T; Shima Y; Podar K; Anderson K C
Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6347-55.
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2000: Abraham D; Podar K; Pacher M; Kubicek M; Welzel N; Hemmings B A; Dilworth S M; Mischak H; Kolch W; Baccarini M
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.
The Journal of biological chemistry 2000;275(29):22300-4.
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