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klaus podar

Research Profile

Disorders

Multiple Myeloma

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klaus podar; Martin Sattler; Yu-Tzu Tai; Giovanni Tonon; Sonia Vallet; Alexander Zimmerhackl; Dharminder Chauhan; Mariateresa Fulciniti; Ursula Hainz; Niels Halama; Dirk Jäger; Dian L Olson; Kenneth C Anderson
The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications.
Margret S Fernandes; Mamatha M Reddy; Nicole J Croteau; Christoph Walz; Henry Weisbach; klaus podar; Hamid Band; Martin Carroll; Andreas Reiter; Richard A Larson; Ravi Salgia; James D Griffin; Martin Sattler
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
klaus podar; Kenneth C Anderson
A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways.

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All Publications

2011: klaus podar; Martin Sattler; Yu-Tzu Tai; Giovanni Tonon; Sonia Vallet; Alexander Zimmerhackl; Dharminder Chauhan; Mariateresa Fulciniti; Ursula Hainz; Niels Halama; Dirk Jäger; Dian L Olson; Kenneth C Anderson
The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications.
British journal of haematology 2011;155(4):438-48.
2010: Margret S Fernandes; Mamatha M Reddy; Nicole J Croteau; Christoph Walz; Henry Weisbach; klaus podar; Hamid Band; Martin Carroll; Andreas Reiter; Richard A Larson; Ravi Salgia; James D Griffin; Martin Sattler
Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
The Journal of biological chemistry 2010;285(42):32596-605.
2010: klaus podar; Kenneth C Anderson
A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways.
Cell cycle (Georgetown, Tex.) 2010;9(9):1722-8.
2010: Kihyun Kim; Sun-Young Kong; Mariateresa Fulciniti; Xianfeng Li; Weihua Song; Sabikun Nahar; Peter C Burger; Mathew J Rumizen; klaus podar; Dharminder Chauhan; Teru Hideshima; Nikhil C Munshi; Paul Richardson; Ann Clark; Janet Ogden; Andreas Goutopoulos; Luca Rastelli; Kenneth C Anderson; Yu-Tzu Tai
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
British journal of haematology 2010;149(4):537-49.
2009: Simona Blotta; Pierfrancesco Tassone; Rao H Prabhala; Pierosandro Tagliaferri; David Cervi; Samir Amin; Jana Jakubikova; Yu-Tzu Tai; klaus podar; Constantine S Mitsiades; Alessandro Zullo; Brunella Franco; Kenneth C Anderson; Nikhil C Munshi
Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.
Blood 2009;114(15):3276-84.
2009: Dharminder Chauhan; Ajita V Singh; Mohan Brahmandam; Ruben Carrasco; Madhavi Bandi; Teru Hideshima; Giada Bianchi; klaus podar; Yu-Tzu Tai; Constantine Mitsiades; Noopur Raje; David L Jaye; Shaji K Kumar; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Cancer cell 2009;16(4):309-23.
2009: Margret S Fernandes; Mamatha M Reddy; Jeffrey R Gonneville; Scott C DeRoo; klaus podar; James D Griffin; David M Weinstock; Martin Sattler
BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.
Blood 2009;114(9):1813-9.
2009: Teru Hideshima; Hiroshi Ikeda; Dharminder Chauhan; Yutaka Okawa; Noopur Raje; klaus podar; Constantine S Mitsiades; Nikhil C Munshi; Paul G Richardson; Ruben D Carrasco; Kenneth C Anderson
Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells.
Blood 2009;114(5):1046-52.
2009: Marc S Raab; klaus podar; Iris Breitkreutz; Paul G Richardson; Kenneth C Anderson
Multiple myeloma.
Lancet 2009;374(9686):324-39.
2009: Teru Hideshima; Dharminder Chauhan; Tanyel Kiziltepe; Hiroshi Ikeda; Yutaka Okawa; klaus podar; Noopur Raje; Alexei Protopopov; Nikhil C Munshi; Paul G Richardson; Ruben D Carrasco; Kenneth C Anderson
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Blood 2009;113(21):5228-36.
2009: Yu-Tzu Tai; Ender Soydan; Weihua Song; Mariateresa Fulciniti; Kihyun Kim; Fangxin Hong; Xian-Feng Li; Peter C Burger; Matthew J Rumizen; Sabikun Nahar; klaus podar; Teru Hideshima; Nikhil C Munshi; Giovanni Tonon; Ruben D Carrasco; Daniel E H Afar; Kenneth C Anderson
CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.
Blood 2009;113(18):4309-18.
2009: klaus podar; Yu-Tzu Tai; Teru Hideshima; Sonia Vallet; Paul G Richardson; Kenneth C Anderson
Emerging therapies for multiple myeloma.
Expert opinion on emerging drugs 2009;14(1):99-127.
2009: Renate Burger; Steven Le Gouill; Yu-Tzu Tai; Reshma Shringarpure; Pierfrancesco Tassone; Paola Neri; klaus podar; Laurence Catley; Teru Hideshima; Dharminder Chauhan; Eian Caulder; Claire L Neilan; Kris Vaddi; Jun Li; Martin Gramatzki; Jordan S Fridman; Kenneth C Anderson
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.
Molecular cancer therapeutics 2009;8(1):26-35.
2008: Yu-Tzu Tai; Myles Dillon; Weihua Song; Merav Leiba; Xian-Feng Li; Peter C Burger; Alfred I Lee; klaus podar; Teru Hideshima; Audie G Rice; A van Abbema; Lynne Jesaitis; Ingrid Caras; Debbie Law; Edie Weller; Wanling Xie; Paul G Richardson; Nikhil C Munshi; Claire Mathiot; Hervé Avet-Loiseau; Daniel E H Afar; Kenneth C Anderson
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
Blood 2008;112(4):1329-37.
2008: Gerlinde Wernig; Jeffrey R Gonneville; Brian J Crowley; Margret S Rodrigues; Mamatha M Reddy; Heidi E Hudon; Christoph Walz; Andreas Reiter; klaus podar; Yohan Royer; Stefan N Constantinescu; Michael H Tomasson; James D Griffin; D Gary Gilliland; Martin Sattler
The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
Blood 2008;111(7):3751-9.
2008: Dharminder Chauhan; Ajita Singh; Mohan Brahmandam; klaus podar; Teru Hideshima; Paul Richardson; Nikhil C Munshi; Michael A Palladino; Kenneth C Anderson
Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.
Blood 2008;111(3):1654-64.
2008: klaus podar; S L Gouill; J Zhang; J T Opferman; E Zorn; Yu-Tzu Tai; Teru Hideshima; M Amiot; Dharminder Chauhan; Jean-Luc Harousseau; Kenneth C Anderson
A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
Oncogene 2008;27(6):721-31.
2007: klaus podar; Paul G Richardson; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
The malignant clone and the bone-marrow environment.
Best practice & research. Clinical haematology 2007;20(4):597-612.
2007: Sonia Vallet; Noopur Raje; Kenji Ishitsuka; Teru Hideshima; klaus podar; Shweta Chhetri; Samantha Pozzi; Iris Breitkreutz; Tanyel Kiziltepe; Hiroshi Yasui; Enrique M Ocio; Norihiko Shiraishi; Janice Jin; Yutaka Okawa; Hiroshi Ikeda; Siddhartha Mukherjee; Nileshwari Vaghela; Diana Cirstea; marco ladetto; Mario Boccadoro; Kenneth C Anderson
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.
Blood 2007;110(10):3744-52.
2007: klaus podar; Marc S Raab; Dharminder Chauhan; Kenneth C Anderson
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies.
Expert opinion on investigational drugs 2007;16(10):1693-707.
2007: Teru Hideshima; Laurence Catley; Noopur Raje; Dharminder Chauhan; klaus podar; Constantine S Mitsiades; Yu-Tzu Tai; Sonia Vallet; Tanyel Kiziltepe; Enrique M Ocio; Hiroshi Ikeda; Yutaka Okawa; Hiromasa Hideshima; Nikhil C Munshi; Hiroshi Yasui; Paul G Richardson; Kenneth C Anderson
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
British journal of haematology 2007;138(6):783-91.
2007: Yu-Tzu Tai; Mariateresa Fulciniti; Teru Hideshima; Weihua Song; Merav Leiba; Xian-Feng Li; Matthew Rumizen; Peter C Burger; Aileen Morrison; klaus podar; Dharminder Chauhan; Pierfrancesco Tassone; Paul Richardson; Nikhil C Munshi; Irene M Ghobrial; Kenneth C Anderson
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Blood 2007;110(5):1656-63.
2007: Anne-Sophie Moreau; Xiaoying Jia; Hai T Ngo; Xavier Leleu; Garrett O'Sullivan; Yazan Alsayed; Alexey A Leontovich; klaus podar; Jeffery L Kutok; John Daley; Suzan Lazo-Kallanian; Evdoxia Hatjiharissi; Marc S Raab; Lian Xu; Steve P Treon; Teru Hideshima; Kenneth C Anderson; Irene M Ghobrial
Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.
Blood 2007;109(11):4964-72.
2007: Dharminder Chauhan; Mugdha Velankar; M Brahmandam; Teru Hideshima; klaus podar; Paul Richardson; Robert Schlossman; Irene M Ghobrial; Noopur Raje; Nikhil C Munshi; Kenneth C Anderson
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
Oncogene 2007;26(16):2374-80.
2007: klaus podar; Paul G Richardson; Dharminder Chauhan; Kenneth C Anderson
Targeting the vascular endothelial growth factor pathway in the treatment of multiple myeloma.
Expert review of anticancer therapy 2007;7(4):551-66.
2007: klaus podar; Kenneth C Anderson
Inhibition of VEGF signaling pathways in multiple myeloma and other malignancies.
Cell cycle (Georgetown, Tex.) 2007;6(5):538-42.
2007: Hiroshi Yasui; Teru Hideshima; H Ikeda; Enrique M Ocio; Tanyel Kiziltepe; Sonia Vallet; Y Okawa; Paola Neri; Kumar Sukhdeo; klaus podar; Dharminder Chauhan; Paul G Richardson; Noopur Raje; Daniel R Carrasco; Kenneth C Anderson
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of beta-catenin/TCF pathway.
Leukemia 2007;21(3):535-40.
2007: klaus podar; Marc S Raab; Giovanni Tonon; Martin Sattler; Daniela Barilà; Jing Zhang; Yu-Tzu Tai; Hiroshi Yasui; Noopur Raje; Ronald A DePinho; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
Cancer research 2007;67(4):1680-8.
2007: klaus podar; Marc S Raab; Jing Zhang; Douglas W McMillin; Iris Breitkreutz; Yu-Tzu Tai; Boris K Lin; Nikhil C Munshi; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Blood 2007;109(4):1669-77.
2007: Hiroshi Yasui; Teru Hideshima; Hiroshi Ikeda; Janice Jin; Enrique M Ocio; Tanyel Kiziltepe; Yutaka Okawa; Sonia Vallet; klaus podar; Kenji Ishitsuka; Paul G Richardson; Christopher A Pargellis; Neil Moss; Noopur Raje; Kenneth C Anderson
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth.
British journal of haematology 2007;136(3):414-23.
2007: Dharminder Chauhan; Paola Neri; Mugdha Velankar; klaus podar; Teru Hideshima; Mariateresa Fulciniti; Pierfrancesco Tassone; Noopur Raje; Constantine S Mitsiades; Nicholas Mitsiades; Paul Richardson; Leigh Zawel; Mary Tran; Nikhil C Munshi; Kenneth C Anderson
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM).
Blood 2007;109(3):1220-7.
2007: klaus podar; Noopur Raje; Kenneth C Anderson
Inhibition of the TGF-beta signaling pathway in tumor cells.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;172():77-97.
2006: klaus podar; Giovanni Tonon; Martin Sattler; Yu-Tzu Tai; Steven Legouill; Hiroshi Yasui; Kenji Ishitsuka; Shaji Kumar; Rakesh Kumar; Lini Pandite; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19478-83.
2006: Ellen Weisberg; Renee D Wright; Jingrui Jiang; Arghya Ray; Daisy Moreno; Paul W Manley; Doriano Fabbro; Elizabeth Hall-Meyers; Laurence Catley; klaus podar; Andrew L Kung; James D Griffin
Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.
Gastroenterology 2006;131(6):1734-42.
2006: Teru Hideshima; Paola Neri; Pierfrancesco Tassone; Hiroshi Yasui; Kenji Ishitsuka; Noopur Raje; Dharminder Chauhan; klaus podar; Constantine S Mitsiades; Lenny Dang; Nikhil C Munshi; Paul Richardson; David P Schenkein; Kenneth C Anderson
MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5887-94.
2006: Reshma Shringarpure; Laurence Catley; Deepak Bhole; Renate Burger; klaus podar; Yu-Tzu Tai; Benedikt Kessler; Paul J Galardy; Hidde L Ploegh; Pierfrancesco Tassone; Teru Hideshima; Constantine S Mitsiades; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
2006: Yu-Tzu Tai; Xian-Feng Li; Iris Breitkreutz; Weihua Song; Paola Neri; Laurence Catley; klaus podar; Teru Hideshima; Dharminder Chauhan; Noopur Raje; Robert Schlossman; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2006;66(13):6675-82.
2006: Christoph Walz; Brian J Crowley; Heidi E Hudon; Jessica L Gramlich; Donna Neuberg; klaus podar; James D Griffin; Martin Sattler
Activated Jak2 with the V617F point mutation promotes G1/S phase transition.
The Journal of biological chemistry 2006;281(26):18177-83.
2006: Teru Hideshima; Laurence Catley; Hiroshi Yasui; Kenji Ishitsuka; Noopur Raje; Constantine S Mitsiades; klaus podar; Nikhil C Munshi; Dharminder Chauhan; Paul G Richardson; Kenneth C Anderson
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells.
Blood 2006;107(10):4053-62.
2006: Shaji Kumar; Noopur Raje; Teru Hideshima; Kenji Ishitsuka; klaus podar; Steven Le Gouille; Dharminder Chauhan; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
FQPD, a novel immunomodulatory drug, has significant in vitro activity in multiple myeloma.
British journal of haematology 2006;132(6):698-704.
2006: klaus podar; Kenneth C Anderson
Caveolin-1 as a potential new therapeutic target in multiple myeloma.
Cancer letters 2006;233(1):10-5.
2005: Yu-Tzu Tai; Xian-Feng Li; Laurence Catley; Rory Coffey; Iris Breitkreutz; Jooeun Bae; Weihua Song; klaus podar; Teru Hideshima; Dharminder Chauhan; Robert Schlossman; Paul Richardson; Steve P Treon; Iqbal Grewal; Nikhil C Munshi; Kenneth C Anderson
Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Cancer research 2005;65(24):11712-20.
2005: Dharminder Chauhan; Laurence Catley; Guilan Li; klaus podar; Teru Hideshima; Mugdha Velankar; Constantine S Mitsiades; Nicholas Mitsiades; Hiroshi Yasui; Anthony Letai; Huib Ovaa; Celia R Berkers; Benjamin Nicholson; Ta-Hsiang Chao; Saskia T C Neuteboom; Paul Richardson; Michael A Palladino; Kenneth C Anderson
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib.
Cancer cell 2005;8(5):407-19.
2005: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Paola Neri; Deli He; Nicholas Mitsiades; Paul Richardson; Yan Chang; Joanne Schindler; Bradley Carver; Kenneth C Anderson
A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells.
Cancer research 2005;65(18):8350-8.
2005: Kenji Ishitsuka; Teru Hideshima; Makoto Hamasaki; Noopur Raje; Shaji Kumar; klaus podar; Steven Le Gouill; Norihiko Shiraishi; Hiroshi Yasui; Aldo Roccaro; Yu-Zu Tai; Dharminder Chauhan; Robert Fram; Kazuo Tamura; Jugnu Jain; Kenneth C Anderson
Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway.
Oncogene 2005;24(38):5888-96.
2005: Kenji Ishitsuka; Teru Hideshima; Makoto Hamasaki; Noopur Raje; Shaji Kumar; Hiromasa Hideshima; Norihiko Shiraishi; Hiroshi Yasui; Aldo Roccaro; Paul Richardson; klaus podar; Steven Le Gouill; Dharminder Chauhan; Kazuo Tamura; Jack Arbiser; Kenneth C Anderson
Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.
Blood 2005;106(5):1794-800.
2005: Hiroshi Yasui; Teru Hideshima; Noopur Raje; Aldo Roccaro; Norihiko Shiraishi; Shaji Kumar; Makoto Hamasaki; Kenji Ishitsuka; Yu-Tzu Tai; klaus podar; Laurence Catley; Constantine S Mitsiades; Paul G Richardson; Rainer Albert; Volker Brinkmann; Dharminder Chauhan; Kenneth C Anderson
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Cancer research 2005;65(16):7478-84.
2005: Hiroshi Yasui; Teru Hideshima; Makoto Hamasaki; Aldo Roccaro; Norihiko Shiraishi; Shaji Kumar; Pierfrancesco Tassone; Kenji Ishitsuka; Noopur Raje; Yu-Tzu Tai; klaus podar; Dharminder Chauhan; Lorenzo Leoni; Sarath Kanekal; Gary Elliott; Nikhil C Munshi; Kenneth C Anderson
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Blood 2005;106(2):706-12.
2005: Yu-Tzu Tai; Xianfeng Li; Xia Tong; Daniel Santos; Takemi Otsuki; Laurence Catley; Olivier Tournilhac; klaus podar; Teru Hideshima; Robert Schlossman; Paul Richardson; Nikhil C Munshi; Mohammad Luqman; Kenneth C Anderson
Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma.
Cancer research 2005;65(13):5898-906.
2005: Pierfrancesco Tassone; Paola Neri; Renate Burger; Rocco Savino; Masood Ahmad Shammas; Laurence Catley; klaus podar; Dharminder Chauhan; Serena Masciari; Antonella Gozzini; Pierosandro Tagliaferri; Salvatore Venuta; Nikhil C Munshi; Kenneth C Anderson
Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4251-8.
2005: Teru Hideshima; Dharminder Chauhan; Kenji Ishitsuka; Hiroshi Yasui; Noopur Raje; Shaji Kumar; klaus podar; Constantine S Mitsiades; Hiromasa Hideshima; Lynn Bonham; Nikhil C Munshi; Paul G Richardson; Jack W Singer; Kenneth C Anderson
Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors.
Oncogene 2005;24(19):3121-9.
2005: klaus podar; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Targeting signalling pathways for the treatment of multiple myeloma.
Expert opinion on therapeutic targets 2005;9(2):359-81.
2005: Jeong H Kim; Stephanie C Chu; Jessica L Gramlich; Yuri B Pride; Emily Babendreier; Dharminder Chauhan; Ravi Salgia; klaus podar; James D Griffin; Martin Sattler
Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species.
Blood 2005;105(4):1717-23.
2005: klaus podar; Kenneth C Anderson
The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications.
Blood 2005;105(4):1383-95.
2005: Teru Hideshima; klaus podar; Dharminder Chauhan; Kenneth C Anderson
Cytokines and signal transduction.
Best practice & research. Clinical haematology 2005;18(4):509-24.
2005: Toshiaki Hayashi; Teru Hideshima; Masaharu Akiyama; klaus podar; Hiroshi Yasui; Noopur Raje; Shaji Kumar; Dharminder Chauhan; Steve P Treon; Paul G Richardson; Kenneth C Anderson
Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application.
British journal of haematology 2005;128(2):192-203.
2005: Boris Lin; Laurence Catley; Richard LeBlanc; Constantine S Mitsiades; Renate Burger; Yu-Tzu Tai; klaus podar; Markus Wartmann; Dharminder Chauhan; James D Griffin; Kenneth C Anderson
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
Blood 2005;105(1):350-7.
2004: Noopur Raje; Shaji Kumar; Teru Hideshima; Kenji Ishitsuka; Dharminder Chauhan; Constantine S Mitsiades; klaus podar; Steven Le Gouill; Paul Richardson; Nikhil C Munshi; David I Stirling; Joseph H Antin; Kenneth C Anderson
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma.
Blood 2004;104(13):4188-93.
2004: Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Renate Burger; Moni Thi Son; klaus podar; Pierfrancesco Tassone; Dharminder Chauhan; Teru Hideshima; Louis Denis; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Cancer research 2004;64(23):8746-53.
2004: Teru Hideshima; klaus podar; Dharminder Chauhan; Kenji Ishitsuka; Constantine S Mitsiades; Yu-Tzu Tai; Makoto Hamasaki; Noopur Raje; Hiromasa Hideshima; George F Schreiner; Aaron N Nguyen; Tony A Navas; Nikhil C Munshi; Paul G Richardson; Linda S Higgins; Kenneth C Anderson
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Oncogene 2004;23(54):8766-76.
2004: Toshiaki Hayashi; Teru Hideshima; Aaron N Nguyen; Olivier Munoz; klaus podar; Makoto Hamasaki; Kenji Ishitsuka; Hiroshi Yasui; Paul Richardson; Sarvajit Chakravarty; Alison Murphy; Dharminder Chauhan; Linda S Higgins; Kenneth C Anderson
Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7540-6.
2004: Steven Le Gouill; klaus podar; Martine Amiot; Teru Hideshima; Dharminder Chauhan; Kenji Ishitsuka; Shaji Kumar; Noopur Raje; Paul G Richardson; Jean-Luc Harousseau; Kenneth C Anderson
VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis.
Blood 2004;104(9):2886-92.
2004: klaus podar; Reshma Shringarpure; Yu-Tzu Tai; Melissa Simoncini; Martin Sattler; Kenji Ishitsuka; Paul G Richardson; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
Cancer research 2004;64(20):7500-6.
2004: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Constantine S Mitsiades; Robert Schlossman; Nikhil C Munshi; Paul Richardson; Finbarr E Cotter; Kenneth C Anderson
Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells.
Blood 2004;104(8):2458-66.
2004: Steven Le Gouill; klaus podar; Jean-Luc Harousseau; Kenneth C Anderson
Mcl-1 regulation and its role in multiple myeloma.
Cell cycle (Georgetown, Tex.) 2004;3(10):1259-62.
2004: klaus podar; Gustavo Mostoslavsky; Martin Sattler; Yu-Tzu Tai; Toshiaki Hayashi; Laurence Catley; Teru Hideshima; Richard C Mulligan; Dharminder Chauhan; Kenneth C Anderson
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
The Journal of biological chemistry 2004;279(20):21658-65.
2004: klaus podar; Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Pedro Carvalho; Toshiaki Hayashi; Renate Burger; Robert Schlossman; Paul G Richardson; Lini Pandite; Rakesh Kumar; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Blood 2004;103(9):3474-9.
2004: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Reshma Shringarpure; Constantine S Mitsiades; Nikhil C Munshi; Patricia Yew; Kenneth C Anderson
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Oncogene 2004;23(20):3597-602.
2004: Yu-Tzu Tai; Laurence Catley; Constantine S Mitsiades; Renate Burger; klaus podar; Reshma Shringpaure; Teru Hideshima; Dharminder Chauhan; Makoto Hamasaki; Kenji Ishitsuka; Paul Richardson; Steve P Treon; Nikhil C Munshi; Kenneth C Anderson
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Cancer research 2004;64(8):2846-52.
2004: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Reshma Shringarpure; Laurence Catley; Constantine S Mitsiades; Nikhil C Munshi; Yu-Tzu Tai; Nanjoo Suh; Gordon W Gribble; Tadashi Honda; Robert Schlossman; Paul Richardson; Michael B. Sporn; Kenneth C Anderson
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Blood 2004;103(8):3158-66.
2004: Dharminder Chauhan; Guilan Li; Daniel Auclair; Teru Hideshima; klaus podar; Nicholas Mitsiades; Constantine S Mitsiades; Lan Bo Chen; Nikhil C Munshi; S Saxena; Kenneth C Anderson
2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Apoptosis : an international journal on programmed cell death 2004;9(2):149-55.
2003: Teru Hideshima; Dharminder Chauhan; Toshiaki Hayashi; klaus podar; Masaharu Akiyama; Constantine S Mitsiades; Nicholas Mitsiades; Baoqing Gong; Lynn Bonham; Peter de Vries; Nikhil C Munshi; Paul G Richardson; Jack W Singer; Kenneth C Anderson
Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.
Cancer research 2003;63(23):8428-36.
2003: Teru Hideshima; Dharminder Chauhan; Toshiaki Hayashi; Masaharu Akiyama; Nicholas Mitsiades; Constantine S Mitsiades; klaus podar; Nikhil C Munshi; Paul G Richardson; Kenneth C Anderson
Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma.
Oncogene 2003;22(52):8386-93.
2003: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Laurence Catley; Yu-Tzu Tai; Toshiaki Hayashi; Reshma Shringarpure; Renate Burger; Nikhil C Munshi; Yasuyuki Ohtake; Satya Saxena; Kenneth C Anderson
Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Blood 2003;102(9):3379-86.
2003: Dharminder Chauhan; Guilan Li; Reshma Shringarpure; klaus podar; Yasuyuki Ohtake; Teru Hideshima; Kenneth C Anderson
Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells.
Cancer research 2003;63(19):6174-7.
2003: Dharminder Chauhan; Guilan Li; Martin Sattler; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Nikhil C Munshi; Teru Hideshima; Kenneth C Anderson
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Oncogene 2003;22(40):6296-300.
2003: Yu-Tzu Tai; klaus podar; Laurence Catley; Yu-Hua Tseng; Masaharu Akiyama; Reshma Shringarpure; Renate Burger; Teru Hideshima; Dharminder Chauhan; Nicholas Mitsiades; Paul Richardson; Nikhil C Munshi; C Ronald Kahn; Constantine S Mitsiades; Kenneth C Anderson
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
2003: Martin Sattler; Yuri B Pride; Patrick Ma; Jessica L Gramlich; Stephanie C Chu; Laura A Quinnan; Sheri Shirazian; Congxin Liang; klaus podar; James G Christensen; Ravi Salgia
A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
Cancer research 2003;63(17):5462-9.
2003: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Nikhil C Munshi; Surender Kharbanda; Kenneth C Anderson
JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells.
The Journal of biological chemistry 2003;278(20):17593-6.
2003: Dharminder Chauhan; Guilan Li; Daniel Auclair; Teru Hideshima; Paul Richardson; klaus podar; Nicholas Mitsiades; Constantine S Mitsiades; Cheng Li; Ryung S. Kim; Nikhil C Munshi; Lan Bo Chen; Wing Wong; Kenneth C Anderson
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Blood 2003;101(9):3606-14.
2003: Yu-Tzu Tai; klaus podar; Nicholas Mitsiades; Boris Lin; Constantine S Mitsiades; Deepak Gupta; Masaharu Akiyama; Laurence Catley; Teru Hideshima; Nikhil C Munshi; Steve P Treon; Kenneth C Anderson
CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Blood 2003;101(7):2762-9.
2003: klaus podar; Yu-Tzu Tai; Craig E Cole; Teru Hideshima; Martin Sattler; Angela Hamblin; Nicholas Mitsiades; Robert Schlossman; Faith E Davies; Gareth J Morgan; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
The Journal of biological chemistry 2003;278(8):5794-801.
2003: Teru Hideshima; Constantine S Mitsiades; Masaharu Akiyama; Toshiaki Hayashi; Dharminder Chauhan; Paul Richardson; Robert Schlossman; klaus podar; Nikhil C Munshi; Nicholas Mitsiades; Kenneth C Anderson
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.
Blood 2003;101(4):1530-4.
2003: Suzanne Lentzsch; Richard LeBlanc; klaus podar; Faith Davies; Boris Lin; Teru Hideshima; Laurence Catley; David I Stirling; Kenneth C Anderson
Immunomodulatory analogs of thalidomide inhibit growth of Hs Sultan cells and angiogenesis in vivo.
Leukemia 2003;17(1):41-4.
2002: Dharminder Chauhan; Laurence Catley; Teru Hideshima; Guilan Li; Richard LeBlanc; Deepak Gupta; Martin Sattler; Paul Richardson; Robert Schlossman; klaus podar; Edie Weller; Nikhil C Munshi; Kenneth C Anderson
2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Blood 2002;100(6):2187-94.
2002: Boris Lin; klaus podar; Deepak Gupta; Yu-Tzu Tai; Sigui Li; Edie Weller; Teru Hideshima; Suzanne Lentzsch; Faith Davies; Cheng Li; Ellen Weisberg; Robert Schlossman; Paul G Richardson; James D Griffin; Jeanette Wood; Nikhil C Munshi; Kenneth C Anderson
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2002;62(17):5019-26.
2002: Deepak Gupta; klaus podar; Yu-Tzu Tai; Boris Lin; Teru Hideshima; Masaharu Akiyama; Richard LeBlanc; Laurence Catley; Nicholas Mitsiades; Constantine S Mitsiades; Dharminder Chauhan; Nikhil C Munshi; Kenneth C Anderson
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Experimental hematology 2002;30(7):711-20.
2002: Martin Sattler; M Golam Mohi; Yuri B Pride; Laura R Quinnan; Nicole A Malouf; klaus podar; Franck Gesbert; Hiromi Iwasaki; Shaoguang Li; Richard A Van Etten; Haihua Gu; James D Griffin; Benjamin G Neel
Critical role for Gab2 in transformation by BCR/ABL.
Cancer cell 2002;1(5):479-92.
2002: Teru Hideshima; Dharminder Chauhan; Toshiaki Hayashi; klaus podar; Masaharu Akiyama; Deepak Gupta; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
The biological sequelae of stromal cell-derived factor-1alpha in multiple myeloma.
Molecular cancer therapeutics 2002;1(7):539-44.
2002: Markus Kubicek; Margit Pacher; Dietmar Abraham; klaus podar; Manfred Eulitz; Manuela Baccarini
Dephosphorylation of Ser-259 regulates Raf-1 membrane association.
The Journal of biological chemistry 2002;277(10):7913-9.
2002: klaus podar; Yu-Tzu Tai; Boris K Lin; Radha P Narsimhan; Martin Sattler; Takashi Kijima; Ravi Salgia; Deepak Gupta; Dharminder Chauhan; Kenneth C Anderson
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
The Journal of biological chemistry 2002;277(10):7875-81.
2002: Yu-Tzu Tai; klaus podar; Stine-Kathrein Kraeft; Fengfei Wang; Gloria Young; Boris Lin; Deepak Gupta; Lan Bo Chen; Kenneth C Anderson
Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications.
Experimental hematology 2002;30(3):212-20.
2002: Dharminder Chauhan; Daniel Auclair; Elisabeth K Robinson; Teru Hideshima; Guilan Li; klaus podar; Deepak Gupta; Paul Richardson; Robert Schlossman; Nancy L Krett; Lan Bo Chen; Nikhil C Munshi; Kenneth C Anderson
Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays.
Oncogene 2002;21(9):1346-58.
2002: Yu-Tzu Tai; klaus podar; Deepak Gupta; Boris Lin; Gloria Young; Masaharu Akiyama; Kenneth C Anderson
CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells.
Blood 2002;99(4):1419-27.
2001: Deepak Gupta; Steve P Treon; Y Shima; Teru Hideshima; klaus podar; Yu-Tzu Tai; Boris Lin; Suzanne Lentzsch; Faith E Davies; Dharminder Chauhan; Robert Schlossman; Paul Richardson; P Ralph; Lei Wu; Faribourz Payvandi; G Muller; David I Stirling; Kenneth C Anderson
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Leukemia 2001;15(12):1950-61.
2001: Teru Hideshima; Dharminder Chauhan; klaus podar; Robert Schlossman; Paul Richardson; Kenneth C Anderson
Novel therapies targeting the myeloma cell and its bone marrow microenvironment.
Seminars in oncology 2001;28(6):607-12.
2001: klaus podar; Yu-Tzu Tai; Faith E Davies; Suzanne Lentzsch; Martin Sattler; Teru Hideshima; Boris K Lin; Deepak Gupta; Y Shima; Dharminder Chauhan; Constantine S Mitsiades; Noopur Raje; Paul Richardson; Kenneth C Anderson
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Blood 2001;98(2):428-35.
2001: Faith E Davies; Noopur Raje; Teru Hideshima; Suzanne Lentzsch; Gloria Young; Yu-Tzu Tai; Boris Lin; klaus podar; Deepak Gupta; Dharminder Chauhan; Steve P Treon; Paul G Richardson; Robert Schlossman; G J Morgan; George W Muller; David I Stirling; Kenneth C Anderson
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Blood 2001;98(1):210-6.
2000: Yu-Tzu Tai; G Teoh; Boris Lin; FE Davies; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; Y Shima; klaus podar; Kenneth C Anderson
Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6347-55.
2000: D Abraham; klaus podar; M Pacher; Markus Kubicek; N Welzel; B A Hemmings; S M Dilworth; Mischak Harald; Walter Kolch; Manuela Baccarini
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.
The Journal of biological chemistry 2000;275(29):22300-4.