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Douglas Freymann

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Procedures

X-Ray Crystallography

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Amino Acid Sequence

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Co-Publications
Name
9
Walter, Peter
8
Focia, Pamela
8
Stroud, Robert
5
Keenan, RJ
4
Ramirez, Ursula
3
Shepotinovskaya, Irina
3
Gawronski-Salerno, Joseph
2
Coon, John
2
Schmitz, U
2
James, Tom
1
Alam, Hena
1
Reiling, Keith K.
1
Wenck, Mary Anne
1
Wiley, Don
1
Yaseen, Nabeel

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Publications

TOP 3
Ramirez Ursula D; Focia Pamela J; Freymann Douglas M
Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh.
Gawronski-Salerno Joseph; Freymann Douglas M
Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY.
Gawronski-Salerno Joseph; Coon John S; Focia Pamela J; Freymann Douglas M
X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases.

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All Publications

2008: Ramirez Ursula D; Focia Pamela J; Freymann Douglas M
Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 10):1043-53.
2007: Gawronski-Salerno Joseph; Freymann Douglas M
Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY.
Journal of structural biology 2007;158(1):122-8.
2007: Gawronski-Salerno Joseph; Coon John S; Focia Pamela J; Freymann Douglas M
X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases.
Proteins 2007;66(4):984-95.
2006: Ramirez Ursula D; Freymann Douglas M
Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1520-34.
2006: Focia Pamela J; Gawronski-Salerno Joseph; Coon John S; Freymann Douglas M
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.
Journal of molecular biology 2006;360(3):631-43.
2004: Bibak Niloufar; Paul Rachelle M J; Freymann Douglas M; Yaseen Nabeel R
Purification of RanGDP, RanGTP, and RanGMPPNP by ion exchange chromatography.
Analytical biochemistry 2004;333(1):57-64.
2004: Focia Pamela J; Alam Hena; Lu Thanh; Ramirez Ursula D; Freymann Douglas M
Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh.
Proteins 2004;54(2):222-30.
2004: Focia Pamela J; Shepotinovskaya Irina V; Seidler James A; Freymann Douglas M
Heterodimeric GTPase core of the SRP targeting complex.
Science (New York, N.Y.) 2004;303(5656):373-7.
2003: Shepotinovskaya Irina V; Focia Pamela J; Freymann Douglas M
Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 10):1834-7.
2002: Ramirez Ursula D; Minasov George; Focia Pamela J; Stroud Robert M; Walter Peter; Kuhn Peter; Freymann Douglas M
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.
Journal of molecular biology 2002;320(4):783-99.
2002: Shepotinovskaya Irina V; Freymann Douglas M
Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY.
Biochimica et biophysica acta 2002;1597(1):107-14.
2002: Murthy S N Prasanna; Iismaa Siiri; Begg Gillian; Freymann Douglas M; Graham Robert M; Lorand Laszlo
Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2738-42.
2001: Padmanabhan S; Freymann D M
The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase.
Structure (London, England : 1993) 2001;9(9):859-67.
2001: Keenan R J; Freymann D M; Stroud R M; Walter P
The signal recognition particle.
Annual review of biochemistry 2001;70():755-75.
2000: Freymann D M; Wenck M A; Engel J C; Feng J; Focia P J; Eakin A E; Craig S P
Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi.
Chemistry & biology 2000;7(12):957-68.
2000: Peluso P; Herschlag D; Nock S; Freymann D M; Johnson A E; Walter P
Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor.
Science (New York, N.Y.) 2000;288(5471):1640-3.
2000: Anderson A C; Perry K M; Freymann D M; Stroud R M
The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design.
Journal of molecular biology 2000;297(3):645-57.
1999: Schmitz U; Behrens S; Freymann D M; Keenan R J; Lukavsky P; Walter P; James T L
Structure of the phylogenetically most conserved domain of SRP RNA.
RNA (New York, N.Y.) 1999;5(11):1419-29.
1999: Freymann D M; Keenan R J; Stroud R M; Walter P
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nature structural biology 1999;6(8):793-801.
1998: Stroud R M; Reiling K; Wiener M; Freymann D
Ion-channel-forming colicins.
Current opinion in structural biology 1998;8(4):525-33.
1998: Keenan R J; Freymann D M; Walter P; Stroud R M
Crystal structure of the signal sequence binding subunit of the signal recognition particle.
Cell 1998;94(2):181-91.
1997: Wiener M; Freymann D; Ghosh P; Stroud R M
Crystal structure of colicin Ia.
Nature 1997;385(6615):461-4.
1997: Freymann D M; Keenan R J; Stroud R M; Walter P
Structure of the conserved GTPase domain of the signal recognition particle.
Nature 1997;385(6614):361-4.
1996: Schmitz U; Freymann D M; James T L; Keenan R J; Vinayak R; Walter P
NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP).
RNA (New York, N.Y.) 1996;2(12):1213-27.
1993: Bernstein H D; Zopf D; Freymann D M; Walter P
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5229-33.
1990: Freymann D; Down J; Carrington M; Roditi I; Turner M; Wiley D
2.9 A resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei.
Journal of molecular biology 1990;216(1):141-60.
1987: Metcalf P; Blum M; Freymann D; Turner M; Wiley D C
Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 A resolution X-ray structures.
Nature 1987;325(6099):84-6.
1986: Durbin R M; Burns R; Moulai J; Metcalf P; Freymann D; Blum M; Anderson J E; Harrison S C; Wiley D C
Protein, DNA, and virus crystallography with a focused imaging proportional counter.
Science (New York, N.Y.) 1986;232(4754):1127-32.
1984: Freymann D M; Metcalf P; Turner M; Wiley D C
6 A-resolution X-ray structure of a variable surface glycoprotein from Trypanosoma brucei.
Nature 1984;311(5982):167-9.

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