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Edwin Cuppen

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Martijn P Lolkema; Nancy Roach; Annelien L Bredenoord; Edwin Cuppen; Christa G Gadellaa-van Hooijdonk; Peter Kapitein; Nine V Knoers; Emile E Voest
Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology.
Magdalena Harakalova; Xavier Jeunemaitre; Irene Joziasse; Dick Lindhout; Jelena Medic; Isaäc J Nijman; Gerard Pals; Martin Poot; Jolien W Roos-Hesselink; Jasper J van der Smagt; Ruben van't Slot; Marjan M Weiss; Marja W Wessels; Edwin Cuppen; Carolien G F de Kovel; Jaap Deckers; Lisa Golmard; Hubert F Baars; Annette F Baas
Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.
Ross N W Kettleborough; Selina Mehroke; Isaac J Nijman; Catherine Scahill; Ian Sealy; Freek van Eeden; Neha Wali; Richard J White; Jennifer Yen; Elisabeth M Busch-Nentwich; Samantha Carruthers; Edwin Cuppen; Ewart de Bruijn; Christopher M Dooley; Fruzsina Fényes; Richard Gibbons; Amanda Hall; Steven A Harvey; Colin Herd; Derek L Stemple
A systematic genome-wide analysis of zebrafish protein-coding gene function.

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2013: Martijn P Lolkema; Nancy Roach; Annelien L Bredenoord; Edwin Cuppen; Christa G Gadellaa-van Hooijdonk; Peter Kapitein; Nine V Knoers; Emile E Voest
Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013;31(15):1842-8.
2013: Magdalena Harakalova; Xavier Jeunemaitre; Irene Joziasse; Dick Lindhout; Jelena Medic; Isaäc J Nijman; Gerard Pals; Martin Poot; Jolien W Roos-Hesselink; Jasper J van der Smagt; Ruben van't Slot; Marjan M Weiss; Marja W Wessels; Edwin Cuppen; Carolien G F de Kovel; Jaap Deckers; Lisa Golmard; Hubert F Baars; Annette F Baas
Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.
European journal of human genetics : EJHG 2013;21(5):487-93.
2013: Ross N W Kettleborough; Selina Mehroke; Isaac J Nijman; Catherine Scahill; Ian Sealy; Freek van Eeden; Neha Wali; Richard J White; Jennifer Yen; Elisabeth M Busch-Nentwich; Samantha Carruthers; Edwin Cuppen; Ewart de Bruijn; Christopher M Dooley; Fruzsina Fényes; Richard Gibbons; Amanda Hall; Steven A Harvey; Colin Herd; Derek L Stemple
A systematic genome-wide analysis of zebrafish protein-coding gene function.
Nature 2013;496(7446):494-7.
2013: Astrid Eijkelenboom; Michal Mokry; Paulien E Polderman; Almut Schulze; Lydia M Smits; Ria van Boxtel; Miranda van Triest; Edwin Cuppen; Wouter de Laat; Elzo de Wit; Boudewijn M T Burgering
Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling.
Molecular systems biology 2013;9():638.
2013: Sebastiaan van Heesch; Shiguo Zhou; Steve Goldstein; Victor Guryev; Timothy T Harkins; Wigard P Kloosterman; Nico Lansu; Clarence C Lee; Elizabeth Levandowsky; Frans-Paul Ruzius; David C Schwartz; Edwin Cuppen
Improving mammalian genome scaffolding using large insert mate-pair next-generation sequencing.
BMC genomics 2013;14():257.
2013: Joram D Mul; Eoghan O'Duibhir; Yogendra B Shrestha; Pim W Toonen; Peter Vargoviç; Eleen Zarebidaki; Edwin Cuppen; Eric Kalkhoven; Arjen Koppen; Richard Kvetnansky; Timothy J Bartness
Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive.
PloS one 2013;8(3):e60214.
2013: Stefanos Leptidis; Sjoukje I Lok; Serv Olieslagers; Gustavo J Silva; Roel de Weger; Leon J De Windt; Hamid El Azzouzi; Stephane Heymans; Natasja Kisters; Eugene Berezikov; Edwin Cuppen; Paula da Costa Martins
A deep sequencing approach to uncover the miRNOME in the human heart.
PloS one 2013;8(2):e57800.
2012: Sylvia F Boj; Pierre Chambon; Edwin Cuppen; Yuval Dor; Cristina Fillat; Andrea Haegebarth; Pantelis Hatzis; Meritxell Huch; Anabel José; Vivian S W Li; Michal Mokry; Maaike van den Born; Johan H van Es; Peter Voshol; Hans Clevers
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Cell 2012;151(7):1595-607.
2012: Karim Nadra; Mario Pende; Jean Sébastien Saulnier-Blache; George M Carman; Pierre Chambon; Edwin Cuppen; Béatrice Desvergne; Sandra Grès; Gil-Soo Han; Jean-Jacques Médard; Daniel Metzger; Joram D Mul; Roman Chrast
Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue.
Molecular and cellular biology 2012;32(23):4794-810.
2012: Joost H M Stassen; Pim W J Vergeer; Edwin Cuppen; Isaäc J Nijman; Michael F Seidl; Berend Snel; Guido Van den Ackerveken
Effector identification in the lettuce downy mildew Bremia lactucae by massively parallel transcriptome sequencing.
Molecular plant pathology 2012;13(7):719-31.
2012: Magdalena Harakalova; Raoul C M Hennekam; Wigard Kloosterman; Nine V A M Knoers; Isaäc J Nijman; Edwin Cuppen; Carolien de Kovel; Karen J Duran; Ivo Renkens; Richard J Sinke; Paulien Terhal; Marie-Jose van den Boogaard; Gijs van Haaften; Mieke M van Haelst; Stef van Lieshout; Marc C van Tuil; Hans Kristian Ploos van Amstel
X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face.
Journal of medical genetics 2012;49(8):539-43.
2012: Sabine A Fuchs; Magdalena Harakalova; Gijs van Haaften; Peter M van Hasselt; Edwin Cuppen; Roderick H J Houwen
Application of exome sequencing in the search for genetic causes of rare disorders of copper metabolism.
Metallomics : integrated biometal science 2012;4(7):606-13.
2012: Joram D Mul; Darleen A Sandoval; Mieke M van Haelst; Stephen C Woods; Gijs van Haaften; Suzanne I M Alsters; Denovan P Begg; Alexandra I F Blakemore; Edwin Cuppen; David A D'Alessio; Karen J Duran; Carel W le Roux; Randy J Seeley
Effect of vertical sleeve gastrectomy in melanocortin receptor 4-deficient rats.
American journal of physiology. Endocrinology and metabolism 2012;303(1):E103-10.
2012: Ron Hochstenbach; Wigard P Kloosterman; Isaäc J Nijman; Hans Kristian Ploos van Amstel; Martin Poot; Ivo Renkens; Paulien Terhal; Ellen van Binsbergen; Bert van der Zwaag; Ruben van't Slot; Maartje J Vogel; Karen J Duran; Edwin Cuppen
Discovery of variants unmasked by hemizygous deletions.
European journal of human genetics : EJHG 2012;20(7):748-53.
2012: Wigard P Kloosterman; Lidia Larizza; Björn Menten; Eberhard Passarge; Martin Poot; Ivo Renkens; Claudia Ruivenkamp; Masoumeh Tavakoli-Yaraki; Ellen van Binsbergen; Arie van Haeringen; Markus J van Roosmalen; Sarah Vergult; Karen J Duran; Daniela Giardino; Victor Guryev; Thomas Haaf; Kerstin Hansson; Ron Hochstenbach; Elly F Ippel; Myrthe Jager; Lucia Ballarati; Edwin Cuppen
Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms.
Cell reports 2012;1(6):648-55.
2012: Hylke M Blauw; Edwin Cuppen; Thomas Gasser; Max Koppers; Robin Lemmens; Albert C Ludolph; Thomas Meyer; R Jeroen Pasterkamp; Wim Robberecht; Claudia Schulte; Philip Van Damme; Wouter van Rheenen; Paul van Vught; Jan Veldink; Stefan Waibel; Leonard H Van den Berg
NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis.
Human molecular genetics 2012;21(11):2497-502.
2012: Andy Itsara; Robert B Jenkins; David A Koolen; Choli Lee; Kevin J Meyer; Karyn Meltz Steinberg; Joris Veltman; Lisenka E L M Vissers; Richard K Wilson; Michael C Zody; Carl Baker; Edwin Cuppen; Joep de Ligt; Tina A Graves; Evan E Eichler
Resolving the breakpoints of the 17q21.31 microdeletion syndrome with next-generation sequencing.
American journal of human genetics 2012;90(4):599-613.
2012: Bart Westendorp; Edwin Cuppen; Marian J A Groot Koerkamp; Frank C P Holstege; Michal Mokry; Alain de Bruin
E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.
Nucleic acids research 2012;40(8):3511-23.
2012: Joram D Mul; Pim W Toonen; Ruben van Boxtel; Keith M Garner; Roger A H Adan; Dylan J M Bergen; Jan H Brakkee; Maike A D Brans; Edwin Cuppen
Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.
Obesity (Silver Spring, Md.) 2012;20(3):612-21.
2012: Joost S Vermaat; Edwin Cuppen; Ewart de Bruijn; Frank L Gerritse; Marco J Koudijs; Nico Lansu; Michal Mokry; Isaäc J Nijman; Wijnand M Roessingh; Stefan J Scherer; Paulus van Diest; Richard van Hillegersberg; Emile E Voest
Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(3):688-99.
2012: Elia Aguado-Fraile; Ignacio Blanco-Sánchez; Bernhard Brüne; Elisa Conde; Edwin Cuppen; Luis del Peso; Edurne Ramos; David Sáenz-Morales; Konstantinos Stamatakis; María Laura García Bermejo
miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target.
PloS one 2012;7(9):e44305.
2012: Jos B Poell; Gregoire P Prevost; Roel Q J Schaapveld; Iman J Schultz; Rick J van Haastert; Paula I van Noort; Mark Verheul; Francesco Cerisoli; Thijs de Gunst; Willemijn M Gommans; Edwin Cuppen
A functional screen identifies specific microRNAs capable of inhibiting human melanoma cell viability.
PloS one 2012;7(8):e43569.
2012: Emily Northrup; Dirk Wedekind; Nils-Holger Zschemisch; Edwin Cuppen; Martina Dorsch; Regina Eisenblätter; Silke Glage; Hans-Jürgen Hedrich
The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.
PloS one 2012;7(5):e38001.
2012: Marieke Simonis; Sebastiaan van Heesch; Tim J Aitman; Santosh S Atanur; Ewart de Bruijn; Laurence Game; Victor Guryev; Steven J M Jones; Nico Lansu; Sam Linsen; Michal Pravenec; Frans-Paul Ruzius; Edwin Cuppen
Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel.
Genome biology 2012;13(4):r31.
2012: Sam E V Linsen; Edwin Cuppen
Methods for small RNA preparation for digital gene expression profiling by next-generation sequencing.
Methods in molecular biology (Clifton, N.J.) 2012;822():205-17.
2011: Magdalena Harakalova; Barbara Hrdlickova; Wigard P Kloosterman; Nico Lansu; Michal Mokry; Isaäc J Nijman; Ivo Renkens; Henk van Roekel; Mark van Roosmalen; Ewart de Bruijn; Karen Duran; Edwin Cuppen
Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing.
Nature protocols 2011;6(12):1870-86.
2011: Marco J Koudijs; Pramudita R Prasetyanti; Eva Schut; Daoud Sie; Jelle ten Hoeve; Louise van der Weyden; Lodewyk Wessels; Theodore Whipp; David J Adams; Edwin Cuppen; Sjors Kas; Christiaan Klijn; Jaap Kool; Jos Jonkers
High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors.
Genome research 2011;21(12):2181-9.
2011: Ruben van Boxtel; Sebastiaan van Heesch; Alain de Bruin; Roel Hermsen; Raoul V Kuiper; Pim W Toonen; Edwin Cuppen
Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.
The American journal of pathology 2011;179(4):1616-22.
2011: R van Boxtel; H van Roekel; Mark Verheul; G Vriend; B Vroling; C Baakman; Victor Guryev; Isaäc J Nijman; P Toonen; Edwin Cuppen
Systematic generation of in vivo G protein-coupled receptor mutants in the rat.
The pharmacogenomics journal 2011;11(5):326-36.
2011: Joram D Mul; Karim Nadra; Isaäc J Nijman; Jean Sébastien Saulnier-Blache; Pim W Toonen; Jos F Brouwers; George M Carman; Roman Chrast; Alain de Bruin; Sandra Grès; Gil-Soo Han; Noorjahan Jagalur Basheer; Jean-Jacques Médard; Dies Meijer; Edwin Cuppen
A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat.
The Journal of biological chemistry 2011;286(30):26781-93.
2011: Magdalena Harakalova; Isaäc J Nijman; Jelena Medic; Michal Mokry; Ivo Renkens; Jan D Blankensteijn; Wigard Kloosterman; Annette F Baas; Edwin Cuppen
Genomic DNA pooling strategy for next-generation sequencing-based rare variant discovery in abdominal aortic aneurysm regions of interest-challenges and limitations.
Journal of cardiovascular translational research 2011;4(3):271-80.
2011: Wigard P Kloosterman; Victor Guryev; Mark van Roosmalen; Karen J Duran; Ewart de Bruijn; Saskia C M Bakker; Tom Letteboer; Bernadette van Nesselrooij; Ron Hochstenbach; Martin Poot; Edwin Cuppen
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline.
Human molecular genetics 2011;20(10):1916-24.
2011: Irene C Joziasse; Kelly A Smith; Sonja Chocron; Maarten van Dinther; Victor Guryev; Jasper J van de Smagt; Edwin Cuppen; Peter ten Dijke; Barbara Jm Mulder; Cheryl L Maslen; Benjamin Reshey; Pieter A Doevendans; Jeroen Bakkers
ALK2 mutation in a patient with Down's syndrome and a congenital heart defect.
European journal of human genetics : EJHG 2011;19(4):389-93.
2011: Annelien L Bredenoord; Hester Y Kroes; Edwin Cuppen; Michael Parker; Johannes J M van Delden
Disclosure of individual genetic data to research participants: the debate reconsidered.
Trends in genetics : TIG 2011;27(2):41-7.
2011: James N Sleigh; Steven D Buckingham; Behrooz Esmaeili; Mohan Viswanathan; Edwin Cuppen; Bethany M Westlund; David B Sattelle
A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds.
Human molecular genetics 2011;20(2):245-60.
2011: Jos B Poell; Roel Q J Schaapveld; Lisette M Timmer; Rick J van Haastert; Andre A F L van Puijenbroek; Eugene Berezikov; Anne S Bolijn; Francesco Cerisoli; Begoña Diosdado-Calvo; Gerrit A Meijer; Edwin Cuppen
Functional microRNA screening using a comprehensive lentiviral human microRNA expression library.
BMC genomics 2011;12():546.
2011: Wigard P Kloosterman; Marco J Koudijs; Isaäc J Nijman; Oscar Paling; Ivo Renkens; Wijnand Roessingh; Masoumeh Tavakoli-Yaraki; Jose van de Belt; Stef van Lieshout; Markus J van Roosmalen; Ruben van 't Slot; Joost S Vermaat; Emile Voest; Victor Guryev; Marlous Hoogstraat; Edwin Cuppen
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.
Genome biology 2011;12(10):R103.
2011: Matthew D Clark; Edwin Cuppen; Panos Deloukas; Victor Guryev; Isaac J Nijman; John H Postlethwait; Masazumi Tada; Catherine Wilson; Ewart de Bruijn; Derek L Stemple
Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish.
Methods in cell biology 2011;104():219-35.
2011: Ross N W Kettleborough; Ewart de Bruijn; Edwin Cuppen; Freek van Eeden; Derek L Stemple
High-throughput target-selected gene inactivation in zebrafish.
Methods in cell biology 2011;104():121-7.
2011: Michal Mokry; Isaäc J Nijman; Ben Scheres; Anja van Dijken; Rene Benjamins; Renze Heidstra; Edwin Cuppen
Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach.
BMC genomics 2011;12():256.
2011: Joram D Mul; Susanne E La Fleur; Pim W Toonen; Anthonieke Afrasiab-Middelman; Rob Binnekade; Dustin Schetters; Michel M M Verheij; Robert M Sears; Judith R Homberg; Anton N M Schoffelmeer; Roger A H Adan; Ralph J DiLeone; Taco J De Vries; Edwin Cuppen
Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat.
PloS one 2011;6(5):e19600.
2011: Carolien Wansleeben; Léon van Gurp; Harma Feitsma; Carla Kroon; Ester Rieter; Marlies Verberne; Victor Guryev; Edwin Cuppen; Frits Meijlink
An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.
PloS one 2011;6(4):e19357.
2011: Nadine Held; Bart M G Smits; Roland Gockeln; Stephanie Schubert; Heike Nave; Emily Northrup; Edwin Cuppen; Hans J Hedrich; Dirk Wedekind
A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats.
PloS one 2011;6(3):e15669.
2011: Ruben van Boxtel; Edwin Cuppen
Generation of genetically modified rodents using random ENU mutagenesis.
Methods in molecular biology (Clifton, N.J.) 2011;693():295-308.
2011: Johnny S W Chan; Eelke M S Snoeren; Edwin Cuppen; Marcel D Waldinger; Berend Olivier; Ronald S Oosting
The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats.
The journal of sexual medicine 2011;8(1):97-108.
2010: Rebecca Lyddon; Edwin Cuppen; Vahram Haroutunian; Larry J Siever; Stella Dracheva
No link of serotonin 2C receptor editing to serotonin transporter genotype.
Neuroreport 2010;21(17):1080-4.
2010: Isaäc J Nijman; Michal Mokry; Ruben van Boxtel; Pim Toonen; Ewart de Bruijn; Edwin Cuppen
Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.
Nature methods 2010;7(11):913-5.
2010: Eelke Snoeren; Johnny Chan; Astrid Bovens; Edwin Cuppen; Marcel D Waldinger; Berend Olivier; Ronald S Oosting
Serotonin transporter null mutation and sexual behavior in female rats: 5-HT1A receptor desensitization.
The journal of sexual medicine 2010;7(7):2424-34.
2010: Santosh S Atanur; Inanç Birol; Victor Guryev; Martin Hirst; Oliver Hummel; Catherine Morrissey; Jacques Behmoaras; Xose M. Fernandez; Michelle D Johnson; William M McLaren; Giannino Patone; Enrico Petretto; Charles Plessy; Kathleen S Rockland; Charles Rockland; Kathrin Saar; Yongjun Zhao; piero carninci; Paul Flicek; Ted Kurtz; Edwin Cuppen; Michal Pravenec; Norbert Hubner; Steven J M Jones; Ewan Birney; Timothy J Aitman
The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
Genome research 2010;20(6):791-803.
2010: Michal Mokry; Harma Feitsma; Isaac J Nijman; Ewart de Bruijn; Pieter J van der Zaag; Victor Guryev; Edwin Cuppen
Accurate SNP and mutation detection by targeted custom microarray-based genomic enrichment of short-fragment sequencing libraries.
Nucleic acids research 2010;38(10):e116.
2010: Edwin Cuppen
DNA isolation from rat tail or ear.
Cold Spring Harbor protocols 2010;2010(5):pdb.prot5434.
2010: Frank Johannes; René Wardenaar; Maria Colomé-Tatché; Florence Mousson; Petra de Graaf; Michal Mokry; Victor Guryev; H Th Marc Timmers; Edwin Cuppen; Ritsert C Jansen
Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq.
Bioinformatics (Oxford, England) 2010;26(8):1000-6.
2010: Carolien Wansleeben; Harma Feitsma; Mireille Montcouquiol; Carla Kroon; Edwin Cuppen; Frits Meijlink
Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.
Development (Cambridge, England) 2010;137(7):1067-73.
2010: Joram D Mul; Chun-Xia Yi; Sjoerd van den Berg; Marieke Ruiter; Pim W Toonen; Martine C J van der Elst; Peter J Voshol; Bart A Ellenbroek; Andries Kalsbeek; Susanne E La Fleur; Edwin Cuppen
Pmch expression during early development is critical for normal energy homeostasis.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E477-88.
2010: Ewout J N Groen; Michael A van Es; Paul van Vught; Wim G M Spliet; Jooyeon van Engelen-Lee; Marianne De Visser; J H J Wokke; H Jurgen Schelhaas; Roel A Ophoff; Katsumi Fumoto; R Jeroen Pasterkamp; Dennis Dooijes; Edwin Cuppen; Jan Veldink; Leonard H Van den Berg
FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands.
Archives of neurology 2010;67(2):224-30.
2010: Carolien Wansleeben; Harma Feitsma; Leon Tertoolen; Carla Kroon; Victor Guryev; Edwin Cuppen; Frits Meijlink
A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.
The International journal of developmental biology 2010;54(10):1465-71.
2010: Michal Mokry; Pantelis Hatzis; Ewart de Bruijn; Jan Koster; Rogier Versteeg; Jurian Schuijers; Marc van de Wetering; Victor Guryev; Hans Clevers; Edwin Cuppen
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles.
PloS one 2010;5(11):e15092.
2010: Ruben van Boxtel; Edwin Cuppen
Rat traps: filling the toolbox for manipulating the rat genome.
Genome biology 2010;11(9):217.
2010: Judith Homberg; Isaäc J Nijman; Sylvia Kuijpers; Edwin Cuppen
Identification of genetic modifiers of behavioral phenotypes in serotonin transporter knockout rats.
BMC genetics 2010;11():37.
2010: Sam E V Linsen; Elzo de Wit; Ewart de Bruijn; Edwin Cuppen
Small RNA expression and strain specificity in the rat.
BMC genomics 2010;11():249.
2010: Ruben van Boxtel; Michael N Gould; Edwin Cuppen; Bart M G Smits
ENU mutagenesis to generate genetically modified rat models.
Methods in molecular biology (Clifton, N.J.) 2010;597():151-67.
2010: Judith R Homberg; Susanne E La Fleur; Edwin Cuppen
Serotonin transporter deficiency increases abdominal fat in female, but not male rats.
Obesity (Silver Spring, Md.) 2010;18(1):137-45.
2009: Filipe Pereira; Sara Queirós; Leonor Gusmão; Isäac J Nijman; Edwin Cuppen; Johannes A Lenstra; Simon J M Davis; Fouad Nejmeddine; António Amorim
Tracing the history of goat pastoralism: new clues from mitochondrial and Y chromosome DNA in North Africa.
Molecular biology and evolution 2009;26(12):2765-73.
2009: Elzo de Wit; Sam E V Linsen; Edwin Cuppen; Eugene Berezikov
Repertoire and evolution of miRNA genes in four divergent nematode species.
Genome research 2009;19(11):2064-74.
2009: J R Homberg; J D Mul; Elzo de Wit; Edwin Cuppen
Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in mu, delta and kappa opioid receptors.
Neuroscience 2009;163(1):308-15.
2009: Sam E V Linsen; Elzo de Wit; Georges Janssens; Sheila Heater; Laura Chapman; Rachael K Parkin; Brian Fritz; Stacia K Wyman; Ewart de Bruijn; Emile E Voest; Scott Kuersten; Muneesh Tewari; Edwin Cuppen
Limitations and possibilities of small RNA digital gene expression profiling.
Nature methods 2009;6(7):474-6.
2009: Kelly A Smith; Irene C Joziasse; Sonja Chocron; Maarten van Dinther; Victor Guryev; Manon C Verhoeven; Holger Rehmann; Jasper J van der Smagt; Pieter A Doevendans; Edwin Cuppen; Barbara J Mulder; Peter ten Dijke; Jeroen Bakkers
Dominant-negative ALK2 allele associates with congenital heart defects.
Circulation 2009;119(24):3062-9.
2009: Tatjana Adamovic; Donna McAllister; Victor Guryev; Xujing Wang; Jaime Wendt Andrae; Edwin Cuppen; Howard J Jacob; Sonia L Sugg
Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array-based comparative genomic hybridization.
Cancer research 2009;69(12):5159-67.
2009: Victor Guryev; Edwin Cuppen
Next-generation sequencing approaches in genetic rodent model systems to study functional effects of human genetic variation.
FEBS letters 2009;583(11):1668-73.
2009: Ramadhan Byerengo Matondo; Carine Punt; Judith Homberg; Mathilda J M Toussaint; Ronald Kisjes; Suzanne J A Korporaal; Jan-Willem N Akkerman; Edwin Cuppen; Alain de Bruin
Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(4):G963-8.
2009: Ruud van den Bos; Judith Homberg; Ellen Gijsbers; Esther den Heijer; Edwin Cuppen
The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females.
Neuropharmacology 2009;56(2):493-8.
2009: Sebastiaan A Brittijn; Suzanne J Duivesteijn; Mounia Belmamoune; Laura F M Bertens; Wilbert Bitter; Joost D de Bruijn; D Champagne; Edwin Cuppen; Gert Flik; Christina M.J.E, Vandenbroucke-Grauls; Richard A J Janssen; Ilse M L de Jong; Ron de Kloet; Alexander Kros; Annemarie H Meijer; Juriaan R Metz; Astrid van der Sar; Marcel J M Schaaf; Stefan Schulte-Merker; Herman P Spaink; Paul P Tak; Fons J Verbeek; Margriet J Vervoordeldonk; Freek J Vonk; Frans Witte; Huipin Yuan; Michael K Richardson
Zebrafish development and regeneration: new tools for biomedical research.
The International journal of developmental biology 2009;53(5-6):835-50.
2009: Ewart de Bruijn; Edwin Cuppen; Harma Feitsma
Highly Efficient ENU Mutagenesis in Zebrafish.
Methods in molecular biology (Clifton, N.J.) 2009;546():3-12.
2008: Sam Ev Linsen; Bastiaan B J Tops; Edwin Cuppen
miRNAs: small changes, widespread effects.
Cell research 2008;18(12):1157-9.
2008: Judith R Homberg; Sietse F De Boer; Halfdan S Raasø; Jocelien D A Olivier; Mark Verheul; Eric Ronken; Alexander R Cools; Bart Ellenbroek; Anton N M Schoffelmeer; Louk J M J Vanderschuren; Taco J De Vries; Edwin Cuppen
Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats.
Psychopharmacology 2008;200(3):367-80.
2008: Jocelien D A Olivier; Alexander R Cools; Berend Olivier; Judith R Homberg; Edwin Cuppen; Bart Ellenbroek
Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT(1A) receptor populations: a study in SERT knockout rats.
European journal of pharmacology 2008;590(1-3):190-7.
2008: Harma Feitsma; Raoul V Kuiper; Jeroen Korving; Isaac J Nijman; Edwin Cuppen
Zebrafish with mutations in mismatch repair genes develop neurofibromas and other tumors.
Cancer research 2008;68(13):5059-66.
2008: Judith R Homberg; Ruud van den Bos; Esther den Heijer; Remco Suer; Edwin Cuppen
Serotonin transporter dosage modulates long-term decision-making in rat and human.
Neuropharmacology 2008;55(1):80-4.
2008: Harma Feitsma; Alper Akay; Edwin Cuppen
Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.
Nucleic acids research 2008;36(12):4047-56.
2008: Harma Feitsma; Ewart de Bruijn; Jose van de Belt; Isaac J Nijman; Edwin Cuppen
Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line.
Mutagenesis 2008;23(4):325-9.
2008: Evelien Kruisselbrink; Victor Guryev; Karin Brouwer; Daphne B Pontier; Edwin Cuppen; Marcel Tijsterman
Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.
Current biology : CB 2008;18(12):900-5.
2008: Ruben van Boxtel; Pim W Toonen; Henk S van Roekel; Mark Verheul; Bart M G Smits; Jeroen Korving; Alain de Bruin; Edwin Cuppen
Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.
Carcinogenesis 2008;29(6):1290-7.
2008: Harma Feitsma; Edwin Cuppen
Zebrafish as a cancer model.
Molecular cancer research : MCR 2008;6(5):685-94.
2008: Kathrin Saar; Alfred Beck; Marie-Thérèse Bihoreau; Ewan Birney; Denise Brocklebank; Yuan Chen; Edwin Cuppen; Stephanie Demonchy; Joaquin Dopazo; Paul Flicek; Mario Foglio; Asao Fujiyama; Ivo Gut; Dominique Gauguier; Roderic Guigo; Victor Guryev; Matthias Heinig; Oliver Hummel; Niels Jahn; Sven Klages; Vladimir Kren; Michael Kube; Heiner Kuhl; Takashi Kuramoto; Yoko Kuroki; Doris Lechner; Young-Ae Lee; Nuria Lopez-Bigas; G Mark Lathrop; Tomoji Mashimo; Ignacio Medina; Richard Mott; Giannino Patone; Jeanne-Antide Perrier-Cornet; Matthias Platzer; Michal Pravenec; Richard Reinhardt; Yoshiyuki Sakaki; Markus Schilhabel; Herbert Schulz; Tadao Serikawa; Medya Shikhagaie; Shouji Tatsumoto; Stefan Taudien; Atsushi Toyoda; Birger Voigt; Diana Zelenika; Heike Zimdahl; Norbert Hubner
SNP and haplotype mapping for genetic analysis in the rat.
Nature genetics 2008;40(5):560-6.
2008: Victor Guryev; Kathrin Saar; Tatjana Adamovic; Mark Verheul; Sebastiaan A A C van Heesch; Stuart Cook; Michal Pravenec; Timothy Aitman; Howard Jacob; James D Shull; Norbert Hubner; Edwin Cuppen
Distribution and functional impact of DNA copy number variation in the rat.
Nature genetics 2008;40(5):538-45.
2008: Timothy J Aitman; John K Critser; Edwin Cuppen; Anna Dominiczak; Xose M. Fernandez; Jonathan Flint; Dominique Gauguier; Aron M Geurts; Michael Gould; Peter C Harris; Rikard Holmdahl; Norbert Hubner; Zsuzsanna Izsvák; Howard J Jacob; Takashi Kuramoto; Anne E Kwitek; Anna Marrone; Tomoji Mashimo; Carol Moreno Quinn; John Mullins; Linda Mullins; Tomas Olsson; Michal Pravenec; Lela Riley; Kathrin Saar; Tadao Serikawa; James D Shull; Claude Szpirer; Simon N Twigger; Birger Voigt; Kim Worley
Progress and prospects in rat genetics: a community view.
Nature genetics 2008;40(5):516-22.
2008: Heike Weiss; Tanja Arndt; Anne Jörns; Sigurd Lenzen; Edwin Cuppen; Hans J Hedrich; Markus Tiedge; Dirk Wedekind
The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(4):292-7.
2008: Michal Mokry; Edwin Cuppen
The Atp1a1 gene from inbred Dahl salt sensitive rats does not contain the A1079T missense transversion.
Hypertension 2008;51(4):922-7.
2008: Pantelis Hatzis; Laurens G van der Flier; Marc A van Driel; Victor Guryev; Fiona Nielsen; Sergei Denissov; Isaäc J Nijman; Jan Koster; Evan E Santo; Willem Welboren; Rogier Versteeg; Edwin Cuppen; Marc van de Wetering; Hans Clevers; Hendrik G Stunnenberg
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells.
Molecular and cellular biology 2008;28(8):2732-44.
2008: Marcelo C Leal; Harma Feitsma; Edwin Cuppen; Luiz R França; Rüdiger W Schulz
Completion of meiosis in male zebrafish (Danio rerio) despite lack of DNA mismatch repair gene mlh1.
Cell and tissue research 2008;332(1):133-9.
2008: J D A Olivier; M G C Van Der Hart; R P L Van Swelm; Pieter J W C Dederen; J R Homberg; T Cremers; P M T Deen; Edwin Cuppen; Alexander R Cools; Bart Ellenbroek
A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders.
Neuroscience 2008;152(3):573-84.
2008: Ruben van Boxtel; Pim W Toonen; Mark Verheul; Henk S van Roekel; Isaac J Nijman; Victor Guryev; Edwin Cuppen
Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.
BMC genomics 2008;9():460.
2008: Isaäc J Nijman; Sylvia Kuipers; Mark Verheul; Victor Guryev; Edwin Cuppen
A genome-wide SNP panel for mapping and association studies in the rat.
BMC genomics 2008;9():95.
2007: Ester W Frische; Wendy Pellis-van Berkel; Gijs van Haaften; Edwin Cuppen; Ronald H Plasterk; Marcel Tijsterman; Johannes L Bos; Fried J T Zwartkruis
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
The EMBO journal 2007;26(24):5083-92.
2007: Judith R Homberg; Olga J G Schiepers; Anton N M Schoffelmeer; Edwin Cuppen; Louk J M J Vanderschuren
Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats.
Psychopharmacology 2007;195(2):175-82.
2007: Eugene Berezikov; Wei-Jen Chung; Jason Willis; Edwin Cuppen; Eric C Lai
Mammalian mirtron genes.
Molecular cell 2007;28(2):328-36.
2007: Judith R Homberg; Tommy Pattij; Mieke C W Janssen; Eric Ronken; Sietse F De Boer; Anton N M Schoffelmeer; Edwin Cuppen
Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility.
The European journal of neuroscience 2007;26(7):2066-73.
2007: Judith R Homberg; J D A Olivier; Bart M G Smits; J D Mul; Josine Mudde; Mark Verheul; O F M Nieuwenhuizen; Alexander R Cools; Eric Ronken; T Cremers; Anton N M Schoffelmeer; Bart Ellenbroek; Edwin Cuppen
Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system.
Neuroscience 2007;146(4):1662-76.
2007: Edwin Cuppen; Eelke Gort; Esther Hazendonk; Josine Mudde; Jose van de Belt; Isaäc J Nijman; Victor Guryev; Ronald H Plasterk
Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene.
Genome research 2007;17(5):649-58.
2007: Harma Feitsma; Marcelo C Leal; Peter B Moens; Edwin Cuppen; Rüdiger W Schulz
Mlh1 deficiency in zebrafish results in male sterility and aneuploid as well as triploid progeny in females.
Genetics 2007;175(4):1561-9.
2007: Edwin Cuppen
Genotyping by dideoxy resequencing.
CSH protocols 2007;2007():pdb.prot4842.
2007: Edwin Cuppen
Genotyping by Allele-Specific Amplification (KASPar).
CSH protocols 2007;2007():pdb.prot4841.
2007: Eugene Berezikov; Victor Guryev; Edwin Cuppen
Exploring conservation of transcription factor binding sites with CONREAL.
Methods in molecular biology (Clifton, N.J.) 2007;395():437-48.
2006: Eugene Berezikov; Fritz Thuemmler; Linda W van Laake; Ivanela Kondova; Ronald E Bontrop; Edwin Cuppen; Ronald H Plasterk
Diversity of microRNAs in human and chimpanzee brain.
Nature genetics 2006;38(12):1375-7.
2006: Judith R Homberg; Josine Mudde; Branko Braam; Bart Ellenbroek; Edwin Cuppen; Jaap A Joles
Blood pressure in mutant rats lacking the 5-hydroxytryptamine transporter.
Hypertension 2006;48(6):e115-6; author reply e117.
2006: Eugene Berezikov; Geert van Tetering; Mark Verheul; Jose van de Belt; Linda W van Laake; Joost Vos; Robert E Verloop; Marc van de Wetering; Victor Guryev; Shuji Takada; Anton-Jan van Zonneveld; Hiroyuki Mano; Ronald H Plasterk; Edwin Cuppen
Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis.
Genome research 2006;16(10):1289-98.
2006: Victor Guryev; Bart M G Smits; Jose van de Belt; Mark Verheul; Norbert Hubner; Edwin Cuppen
Haplotype block structure is conserved across mammals.
PLoS genetics 2006;2(7):e121.
2006: Eugene Berezikov; Edwin Cuppen; Ronald H Plasterk
Approaches to microRNA discovery.
Nature genetics 2006;38 Suppl():S2-7.
2006: Victor Guryev; Marco J Koudijs; Eugene Berezikov; Stephen L Johnson; Ronald H Plasterk; Fredericus J M van Eeden; Edwin Cuppen
Genetic variation in the zebrafish.
Genome research 2006;16(4):491-7.
2006: Bart M G Smits; Edwin Cuppen
Rat genetics: the next episode.
Trends in genetics : TIG 2006;22(4):232-40.
2006: Bart M G Smits; Josine Mudde; Jose van de Belt; Mark Verheul; Jocelien Olivier; Judith R Homberg; Victor Guryev; Alexander R Cools; Bart Ellenbroek; Ronald H Plasterk; Edwin Cuppen
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis.
Pharmacogenetics and genomics 2006;16(3):159-69.
2006: Yoshihito Taniguchi; Shunichi Takeda; Makoto Furutani-Seiki; Yasuhiro Kamei; Takeshi Todo; Takao Sasado; Tomonori Deguchi; Hisato Kondoh; Josine Mudde; Mitsuyoshi Yamazoe; Masayuki Hidaka; Hiroshi Mitani; Atsushi Toyoda; Yoshiyuki Sakaki; Ronald H Plasterk; Edwin Cuppen
Generation of medaka gene knockout models by target-selected mutagenesis.
Genome biology 2006;7(12):R116.
2006: Shuji Takada; Eugene Berezikov; Yoshihiro Yamashita; Mariana Lagos-Quintana; Wigard P Kloosterman; Munehiro Enomoto; Hisashi Hatanaka; Shin-ichiro Fujiwara; Hideki Watanabe; Manabu Soda; Young Lim Choi; Ronald H Plasterk; Edwin Cuppen; Hiroyuki Mano
Mouse microRNA profiles determined with a new and sensitive cloning method.
Nucleic acids research 2006;34(17):e115.
2006: Wigard P Kloosterman; Florian A Steiner; Eugene Berezikov; Ewart de Bruijn; Jose van de Belt; Mark Verheul; Edwin Cuppen; Ronald H Plasterk
Cloning and expression of new microRNAs from zebrafish.
Nucleic acids research 2006;34(9):2558-69.
2006: Bart M G Smits; Edwin Cuppen
Rats go genomic.
Genome biology 2006;7(2):306.
2005: Bart M G Smits; Theo A Peters; Joram D Mul; Huib Croes; Jack Fransen; Andy J Beynon; Victor Guryev; Ronald H Plasterk; Edwin Cuppen
Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics.
Genetics 2005;170(4):1887-96.
2005: Eugene Berezikov; Victor Guryev; Edwin Cuppen
CONREAL web server: identification and visualization of conserved transcription factor binding sites.
Nucleic acids research 2005;33(Web Server issue):W447-50.
2005: Edwin Cuppen
Haplotype-based genetics in mice and rats.
Trends in genetics : TIG 2005;21(6):318-22.
2005: Eugene Berezikov; Victor Guryev; Jose van de Belt; Erno Wienholds; Ronald H Plasterk; Edwin Cuppen
Phylogenetic shadowing and computational identification of human microRNA genes.
Cell 2005;120(1):21-4.
2005: Bart M G Smits; Victor Guryev; Dimphy Zeegers; Dirk Wedekind; Hans J Hedrich; Edwin Cuppen
Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates.
BMC genomics 2005;6():170.
2005: Victor Guryev; Eugene Berezikov; Edwin Cuppen
CASCAD: a database of annotated candidate single nucleotide polymorphisms associated with expressed sequences.
BMC genomics 2005;6():10.
2005: Wendy Pellis-van Berkel; M H G Verheijen; Edwin Cuppen; M Asahina; Johan de Rooij; G Jansen; Ronald H Plasterk; Johannes L Bos; Fried J T Zwartkruis
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Molecular biology of the cell 2005;16(1):106-16.
2004: Victor Guryev; Eugene Berezikov; Rainer Malik; Ronald H Plasterk; Edwin Cuppen
Single nucleotide polymorphisms associated with rat expressed sequences.
Genome research 2004;14(7):1438-43.
2004: Bart M G Smits; Bert F M van Zutphen; Ronald H Plasterk; Edwin Cuppen
Genetic variation in coding regions between and within commonly used inbred rat strains.
Genome research 2004;14(7):1285-90.
2004: Bart M G Smits; Ursula M D'Souza; Eugene Berezikov; Edwin Cuppen; Frans Sluyter
Identifying polymorphisms in the Rattus norvegicus D3 dopamine receptor gene and regulatory region.
Genes, brain, and behavior 2004;3(3):138-48.
2004: Bart M G Smits; Josine Mudde; Ronald H Plasterk; Edwin Cuppen
Target-selected mutagenesis of the rat.
Genomics 2004;83(2):332-4.
2004: Eugene Berezikov; Victor Guryev; Ronald H Plasterk; Edwin Cuppen
CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting.
Genome research 2004;14(1):170-8.
2003: Erno Wienholds; Fredericus J M van Eeden; Marit Kosters; Josine Mudde; Ronald H Plasterk; Edwin Cuppen
Efficient target-selected mutagenesis in zebrafish.
Genome research 2003;13(12):2700-7.
2003: Erno Wienholds; Marco J Koudijs; Fredericus J M van Eeden; Edwin Cuppen; Ronald H Plasterk
The microRNA-producing enzyme Dicer1 is essential for zebrafish development.
Nature genetics 2003;35(3):217-8.
2003: Adam F L Hurlstone; Anna-Pavlina G Haramis; Erno Wienholds; Harry Begthel; Jeroen Korving; Fredericus J M van Eeden; Edwin Cuppen; Danica Zivkovic; Ronald H Plasterk; Hans Clevers
The Wnt/beta-catenin pathway regulates cardiac valve formation.
Nature 2003;425(6958):633-7.
2003: Alexander M van der Linden; Celine Moorman; Edwin Cuppen; Hendrik C Korswagen; Ronald H Plasterk
Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C.
Current biology : CB 2003;13(6):516-21.
2003: Edwin Cuppen; Alexander M van der Linden; Gert Jansen; Ronald H Plasterk
Proteins interacting with Caenorhabditis elegans Galpha subunits.
Comparative and functional genomics 2003;4(5):479-91.
2002: Eugene Berezikov; Ronald H Plasterk; Edwin Cuppen
GENOTRACE: cDNA-based local GENOme assembly from TRACE archives.
Bioinformatics (Oxford, England) 2002;18(10):1396-7.
2001: Matilda F Chan; R van Amerongen; T Nijjar; Edwin Cuppen; Peter A Jones; Peter W Laird
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
Molecular and cellular biology 2001;21(22):7587-600.
2001: Alexander M van der Linden; Femke Simmer; Edwin Cuppen; Ronald H Plasterk
The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16.
Genetics 2001;158(1):221-35.
2000: Edwin Cuppen; Marco van Ham; Derick G Wansink; A de Leeuw; Bé Wieringa; Wiljan Hendriks
The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.
European journal of cell biology 2000;79(4):283-93.
1999: Edwin Cuppen; Marco van Ham; Barry A Pepers; Bé Wieringa; Wiljan Hendriks
Identification and molecular characterization of BP75, a novel bromodomain-containing protein.
FEBS letters 1999;459(3):291-8.
1999: Edwin Cuppen; Mietske Wijers; Jan Schepens; Jack Fransen; Bé Wieringa; Wiljan Hendriks
A FERM domain governs apical confinement of PTP-BL in epithelial cells.
Journal of cell science 1999;112 ( Pt 19)():3299-308.
1998: Edwin Cuppen; H Gerrits; Barry A Pepers; Bé Wieringa; Wiljan Hendriks
PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL.
Molecular biology of the cell 1998;9(3):671-83.
1997: Edwin Cuppen; S Nagata; Bé Wieringa; Wiljan Hendriks
No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis.
The Journal of biological chemistry 1997;272(48):30215-20.
1997: Jan Schepens; Edwin Cuppen; Bé Wieringa; Wiljan Hendriks
The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV* carboxyterminal sequences.
FEBS letters 1997;409(1):53-6.