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Devin Leake

Research Profile

Chemicals & Drugs

Disorders

Pachyonychia Congenita

Phenomena

RNA Interference

Anatomy

Living Beings

Mouse

Genes & Molecular Sequences

Genes, Reporter

Physiology

Concepts & Ideas

Molecular Sequence Data

Co-author Network

Publications

TOP 3
Victoria A Meliopoulos; Musa Mhlanga; Kaylene J Simpson; Queta Smith; John Stambas; Cameron R Stewart; Stephen M Tompkins; Lauren E Andersen; Samantha Barichievy; Andrew G D Bean; Katherine F Birrer; Amy Buck; Iain Fraser; Ghil Jona; Jon Karpilow; Devin Leake; John W Lowenthal; Victor W van Beusechem; Ralph A Tripp
Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.
Robyn P Hickerson; Manuel A Flores; Devin Leake; Maria F Lara; Christopher H Contag; Sancy A Leachman; Roger L Kaspar
Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model.
Hyejun Ra; Wibool Piyawattanametha; Emilio Gonzalez-Gonzalez; Michael J Mandella; Gordon S Kino; Olav Solgaard; Devin Leake; Roger L Kaspar; Anthony E Oro; Christopher H Contag
In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope.

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All Publications

2012: Victoria A Meliopoulos; Musa Mhlanga; Kaylene J Simpson; Queta Smith; John Stambas; Cameron R Stewart; Stephen M Tompkins; Lauren E Andersen; Samantha Barichievy; Andrew G D Bean; Katherine F Birrer; Amy Buck; Iain Fraser; Ghil Jona; Jon Karpilow; Devin Leake; John W Lowenthal; Victor W van Beusechem; Ralph A Tripp
Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(4):1372-86.
2011: Robyn P Hickerson; Manuel A Flores; Devin Leake; Maria F Lara; Christopher H Contag; Sancy A Leachman; Roger L Kaspar
Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model.
The Journal of investigative dermatology 2011;131(5):1037-44.
2011: Hyejun Ra; Wibool Piyawattanametha; Emilio Gonzalez-Gonzalez; Michael J Mandella; Gordon S Kino; Olav Solgaard; Devin Leake; Roger L Kaspar; Anthony E Oro; Christopher H Contag
In vivo imaging of human and mouse skin with a handheld dual-axis confocal fluorescence microscope.
The Journal of investigative dermatology 2011;131(5):1061-6.
2011: Robyn P Hickerson; Sancy A Leachman; Lana N Pho; Emilio Gonzalez-Gonzalez; Frances J D Smith; W H Irwin McLean; Christopher H Contag; Devin Leake; Leonard M Milstone; Roger L Kaspar
Development of quantitative molecular clinical end points for siRNA clinical trials.
The Journal of investigative dermatology 2011;131(5):1029-36.
2010: Gunilla B Jacobson; Emilio Gonzalez-Gonzalez; Ryan Spitler; Rajesh Shinde; Devin Leake; Roger L Kaspar; Christopher H Contag; Richard N Zare
Biodegradable nanoparticles with sustained release of functional siRNA in skin.
Journal of pharmaceutical sciences 2010;99(10):4261-6.
2010: Emilio Gonzalez-Gonzalez; Tycho J Speaker; Robyn P Hickerson; Ryan Spitler; Manuel A Flores; Devin Leake; Christopher H Contag; Roger L Kaspar
Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD).
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(9):1667-74.
2010: Barbara Robertson; Andrew B Dalby; Jon Karpilow; Anastasia Khvorova; Devin Leake; Annaleen Vermeulen
Specificity and functionality of microRNA inhibitors.
Silence 2010;1(1):10.
2009: Robyn P Hickerson; Devin Leake; Lana N Pho; Sancy A Leachman; Roger L Kaspar
Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients.
Journal of dermatological science 2009;56(2):82-8.
2009: E Gonzalez-Gonzalez; H Ra; Robyn P Hickerson; Qian Wang; Wibool Piyawattanametha; Michael J Mandella; Gordon S Kino; Devin Leake; A A Avilion; Olav Solgaard; T C Doyle; Christopher H Contag; R L Kaspar
siRNA silencing of keratinocyte-specific GFP expression in a transgenic mouse skin model.
Gene therapy 2009;16(8):963-72.
2008: Emily M Anderson; Amanda Birmingham; Scott Baskerville; Angela Reynolds; Elena Maksimova; Devin Leake; Yuriy Fedorov; Jon Karpilow; Anastasia Khvorova
Experimental validation of the importance of seed complement frequency to siRNA specificity.
RNA (New York, N.Y.) 2008;14(5):853-61.
2008: Robyn P Hickerson; Frances J D Smith; Robert E Reeves; Christopher H Contag; Devin Leake; Sancy A Leachman; Leonard M Milstone; W H Irwin McLean; Roger L Kaspar
Single-nucleotide-specific siRNA targeting in a dominant-negative skin model.
The Journal of investigative dermatology 2008;128(3):594-605.
2008: Frances J D Smith; Robyn P Hickerson; Jane M Sayers; Robert E Reeves; Christopher H Contag; Devin Leake; Roger L Kaspar; W H Irwin McLean
Development of therapeutic siRNAs for pachyonychia congenita.
The Journal of investigative dermatology 2008;128(1):50-8.
2007: Qian Wang; Heini Ilves; Pauline Chu; Christopher H Contag; Devin Leake; Brian H Johnston; Roger L Kaspar
Delivery and inhibition of reporter genes by small interfering RNAs in a mouse skin model.
The Journal of investigative dermatology 2007;127(11):2577-84.
2007: Annaleen Vermeulen; Barbara Robertson; Andrew B Dalby; William S Marshall; Jon Karpilow; Devin Leake; Anastasia Khvorova; Scott Baskerville
Double-stranded regions are essential design components of potent inhibitors of RISC function.
RNA (New York, N.Y.) 2007;13(5):723-30.
2007: Amanda Birmingham; Emily Anderson; Kevin Sullivan; Angela Reynolds; Queta Boese; Devin Leake; Jon Karpilow; Anastasia Khvorova
A protocol for designing siRNAs with high functionality and specificity.
Nature protocols 2007;2(9):2068-78.
2007: Alexander V Vlassov; Brent E Korba; Kristine Farrar; Sampa Mukerjee; Attila A Seyhan; Heini Ilves; Roger L Kaspar; Devin Leake; Sergei A Kazakov; Brian H Johnston
shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA.
Oligonucleotides 2007;17(2):223-36.
2006: Heini Ilves; Roger L Kaspar; Qian Wang; Attila A Seyhan; Alexander V Vlassov; Christopher H Contag; Devin Leake; Brian H Johnston
Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.
Annals of the New York Academy of Sciences 2006;1082():52-5.
2006: Aimee L Jackson; Julja Burchard; Devin Leake; Angela Reynolds; Janell Schelter; Jie Guo; Jason Johnson; Lee Lim; Jon Karpilow; Kim Nichols; William Marshall; Anastasia Khvorova; Peter Linsley
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing.
RNA (New York, N.Y.) 2006;12(7):1197-205.
2006: Yuriy Fedorov; Emily M Anderson; Amanda Birmingham; Angela Reynolds; Jon Karpilow; Kathryn Robinson; Devin Leake; William S Marshall; Anastasia Khvorova
Off-target effects by siRNA can induce toxic phenotype.
RNA (New York, N.Y.) 2006;12(7):1188-96.
2006: Angela Reynolds; Emily M Anderson; Annaleen Vermeulen; Yuriy Fedorov; Kathryn Robinson; Devin Leake; Jon Karpilow; William S Marshall; Anastasia Khvorova
Induction of the interferon response by siRNA is cell type- and duplex length-dependent.
RNA (New York, N.Y.) 2006;12(6):988-93.
2006: Amanda Birmingham; Emily M Anderson; Angela Reynolds; Diane Ilsley-Tyree; Devin Leake; Yuriy Fedorov; Scott Baskerville; Elena Maksimova; Kathryn Robinson; Jon Karpilow; William S Marshall; Anastasia Khvorova
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets.
Nature methods 2006;3(3):199-204.
2005: Derek Radisky; Dinah D Levy; Laurie E Littlepage; Hong Liu; Celeste M Nelson; Jimmie E Fata; Devin Leake; Elizabeth L Godden; Donna G Albertson; Angela Nieto; Zena Werb; Mina J Bissell
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.
Nature 2005;436(7047):123-7.
2005: Queta Boese; Devin Leake; Angela Reynolds; Steven Read; Stephen A Scaringe; William S Marshall; Anastasia Khvorova
Mechanistic insights aid computational short interfering RNA design.
Methods in enzymology 2005;392():73-96.
2004: Angela Reynolds; Devin Leake; Queta Boese; Stephen A Scaringe; William S Marshall; Anastasia Khvorova
Rational siRNA design for RNA interference.
Nature biotechnology 2004;22(3):326-30.
2001: Donald Evans; I Perez; Margaret MacMorris; Devin Leake; C J Wilusz; Thomas Blumenthal
A complex containing CstF-64 and the SL2 snRNP connects mRNA 3' end formation and trans-splicing in C. elegans operons.
Genes & development 2001;15(19):2562-71.
1999: Devin Leake; WS Asch; AK Canger; N Schechter
Gefiltin in zebrafish embryos: sequential gene expression of two neurofilament proteins in retinal ganglion cells.
Differentiation; research in biological diversity 1999;65(4):181-9.
1998: AK Canger; MA Passini; WS Asch; Devin Leake; B T Zafonte; E Glasgow; N Schechter
Restricted expression of the neuronal intermediate filament protein plasticin during zebrafish development.
The Journal of comparative neurology 1998;399(4):561-72.
1998: WS Asch; Devin Leake; AK Canger; MA Passini; F Argenton; N Schechter
Cloning of zebrafish neurofilament cDNAs for plasticin and gefiltin: increased mRNA expression in ganglion cells after optic nerve injury.
Journal of neurochemistry 1998;71(1):20-32.