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Eugene Thonar

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Yejia Zhang; Dessislava Markova; Hee-Jeong Im; WENYANG HU; Eugene Thonar; Tong-Chuan He; Howard S An; Frank M Phillips; D Greg Anderson
Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype.
Kern Singh; Koichi Masuda; Eugene Thonar; Howard S An; Gabriella Cs-Szabo
Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc.
Yejia Zhang; Howard S An; Chadi Tannoury; Eugene Thonar; Mitchell K Freedman; D Greg Anderson
Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.

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2009: Yejia Zhang; Dessislava Markova; Hee-Jeong Im; WENYANG HU; Eugene Thonar; Tong-Chuan He; Howard S An; Frank M Phillips; D Greg Anderson
Primary bovine intervertebral disc cells transduced with adenovirus overexpressing 12 BMPs and Sox9 maintain appropriate phenotype.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2009;88(6):455-63.
2009: Kern Singh; Koichi Masuda; Eugene Thonar; Howard S An; Gabriella Cs-Szabo
Age-related changes in the extracellular matrix of nucleus pulposus and anulus fibrosus of human intervertebral disc.
Spine 2009;34(1):10-6.
2008: Yejia Zhang; Howard S An; Chadi Tannoury; Eugene Thonar; Mitchell K Freedman; D Greg Anderson
Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2008;87(9):694-702.
2008: S D Chua; S P Messier; C Legault; Mary Ellen Lenz; Eugene Thonar; Richard F Loeser
Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the knee.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(9):1047-53.
2008: Anna Asanbaeva; Koichi Masuda; Eugene Thonar; Stephen M Klisch; Robert Sah
Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network.
Biomechanics and modeling in mechanobiology 2008;7(4):263-76.
2008: Stephen M Klisch; Anna Asanbaeva; Sevan R Oungoulian; Koichi Masuda; Eugene Thonar; Andrew Davol; Robert Sah
A cartilage growth mixture model with collagen remodeling: validation protocols.
Journal of biomechanical engineering 2008;130(3):031006.
2008: Hee-Jeong Im; Xin Li; Prasuna Muddasani; Gun-Hee Kim; Francesca Davis; Jayanthi Rangan; Christopher Forsyth; Michael Ellman; Eugene Thonar
Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes.
Journal of cellular physiology 2008;215(2):452-63.
2008: Yejia Zhang; Frank M Phillips; Eugene Thonar; Theodore Oegema; Howard S An; Jorge A. Roman-Blas ; Tong-Chuan He; D Greg Anderson
Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model.
Spine 2008;33(8):831-8.
2008: Xin Li; Howard S An; Michael Ellman; Frank Phillips; Eugene Thonar; Daniel K Park; Ranjith K Udayakumar; Hee-Jeong Im
Action of fibroblast growth factor-2 on the intervertebral disc.
Arthritis research & therapy 2008;10(2):R48.
2008: Michiaki Yamada; Koji Akeda; Kunihiro Asanuma; Eugene Thonar; Howard S An; Atsumasa Uchida; Koichi Masuda
Effect of osteogenic protein-1 on the matrix metabolism of bovine tendon cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(1):42-8.
2008: A Asanbaeva; Koichi Masuda; Eugene Thonar; Stephen M Klisch; Robert Sah
Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(1):1-11.
2007: Yejia Zhang; D Greg Anderson; Frank M Phillips; Eugene Thonar; Tong-Chuan He; Daniel Pietryla; Howard S An
Comparative effects of bone morphogenetic proteins and Sox9 overexpression on matrix accumulation by bovine anulus fibrosus cells: implications for anular repair.
Spine 2007;32(23):2515-20.
2007: Kazuhiro Chiba; Koichi Masuda; Gunnar B J Andersson; Shigeki Momohara; Eugene Thonar
Matrix replenishment by intervertebral disc cells after chemonucleolysis in vitro with chondroitinase ABC and chymopapain.
The spine journal : official journal of the North American Spine Society 2007;7(6):694-700.
2007: V Yellore; Baris Sonmez; Michael C Chen; Sylvia A Rayner; Eugene Thonar; Anthony J Aldave
An unusual presentation of macular corneal dystrophy associated with uniparental isodisomy and a novel Leu173Pro mutation.
Ophthalmic genetics 2007;28(3):169-74.
2007: Yoshiyuki Imai; Kei Miyamoto; Howard S An; Eugene Thonar; Gunnar B J Andersson; Koichi Masuda
Recombinant human osteogenic protein-1 upregulates proteoglycan metabolism of human anulus fibrosus and nucleus pulposus cells.
Spine 2007;32(12):1303-9; discussion 1310.
2007: Yoshiyuki Imai; Masahiko Okuma; Howard S An; Koichi Nakagawa; Michiaki Yamada; Carol Muehleman; Eugene Thonar; Koichi Masuda
Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC.
Spine 2007;32(11):1197-205.
2007: Timothy Ficklin; Gregory Thomas; James C Barthel; Anna Asanbaeva; Eugene Thonar; Koichi Masuda; Albert C Chen; Robert Sah; Andrew Davol; Stephen M Klisch
Articular cartilage mechanical and biochemical property relations before and after in vitro growth.
Journal of biomechanics 2007;40(16):3607-14.
2007: Hasan Othman; Eugene Thonar; Jeremy J Mao
Modulation of neonatal growth plate development by ex vivo intermittent mechanical stress.
Journal of biomechanics 2007;40(12):2686-93.
2007: Anna Asanbaeva; Koichi Masuda; Eugene Thonar; Stephen M Klisch; Robert Sah
Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC.
Arthritis and rheumatism 2007;56(1):188-98.
2006: Koji Akeda; Howard S An; Masahiko Okuma; Mohamed Attawia; Kei Miyamoto; Eugene Thonar; Mary Ellen Lenz; Robert Sah; Koichi Masuda
Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(12):1272-80.
2006: Yoichi Aota; Howard S An; Yoshiyuki Imai; Eugene Thonar; Carol Muehleman; Koichi Masuda
Comparison of cellular response in bovine intervertebral disc cells and articular chondrocytes: effects .of lipopolysaccharide on proteoglycan metabolism.
Cell and tissue research 2006;326(3):787-93.
2006: Daniel-Henri Manicourt; Moïse Azria; Linda Mindeholm; Eugene Thonar; Jean-Pierre Devogelaer
Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritis.
Arthritis and rheumatism 2006;54(10):3205-11.
2006: Yejia Zhang; Howard S An; Eugene Thonar; Susan Chubinskaya; Tong-Chuan He; Frank M Phillips
Comparative effects of bone morphogenetic proteins and sox9 overexpression on extracellular matrix metabolism of bovine nucleus pulposus cells.
Spine 2006;31(19):2173-9.
2006: Kanika Chawla; Travis J Klein; Barbara L Schumacher; Tannin A Schmidt; Michael S Voegtline; Eugene Thonar; Koichi Masuda; Robert Sah
Tracking chondrocytes and assessing their proliferation with PKH26: effects on secretion of proteoglycan 4 (PRG4).
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2006;24(7):1499-508.
2006: Travis J Klein; Barbara L Schumacher; Megan E Blewis; Tannin A Schmidt; Michael S Voegtline; Eugene Thonar; Koichi Masuda; Robert Sah
Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage.
Tissue engineering 2006;12(6):1429-39.
2006: Koji Akeda; Howard S An; Rajeswari Pichika; Mohamed Attawia; Eugene Thonar; Mary Ellen Lenz; Atsumasa Uchida; Koichi Masuda
Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads.
Spine 2006;31(9):959-66.
2006: Koichi Masuda; Yoshiyuki Imai; Masahiko Okuma; Carol Muehleman; Koichi Nakagawa; Koji Akeda; Eugene Thonar; Gunnar Andersson; Howard S An
Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model.
Spine 2006;31(7):742-54.
2006: Koichi Masuda; B E Pfister; Robert Sah; Eugene Thonar
Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(4):384-91.
2006: Steven C Budsberg; Mary Ellen Lenz; Eugene Thonar
Serum and synovial fluid concentrations of keratan sulfate and hyaluronan in dogs with induced stifle joint osteoarthritis following cranial cruciate ligament transection.
American journal of veterinary research 2006;67(3):429-32.
2006: Susan Chubinskaya; Benjamin S Frank; Margaret Michalska; Bhavna Kumar; Charis Merrihew; Eugene Thonar; Mary Ellen Lenz; Lori Otten; David C Rueger; Joel A Block
Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate.
Arthritis research & therapy 2006;8(3):R73.
2005: Yejia Zhang; Zhen Li; Eugene Thonar; Howard S An; Tong-Chuan He; Daniel Pietryla; Frank M Phillips
Transduced bovine articular chondrocytes affect the metabolism of cocultured nucleus pulposus cells in vitro: implications for chondrocyte transplantation into the intervertebral disc.
Spine 2005;30(23):2601-7.
2005: Kei Miyamoto; Howard S An; Robert Sah; Koji Akeda; Masahiko Okuma; Lori Otten; Eugene Thonar; Koichi Masuda
Exposure to pulsed low intensity ultrasound stimulates extracellular matrix metabolism of bovine intervertebral disc cells cultured in alginate beads.
Spine 2005;30(21):2398-405.
2005: Keith P Minihane; Thomas M Turner; Robert M Urban; James M Williams; Eugene Thonar; Dale R Sumner
Effect of hip hemiarthroplasty on articular cartilage and bone in a canine model.
Clinical orthopaedics and related research 2005;(437):157-63.
2005: Kenji Takegami; Howard S An; Fumio Kumano; Kazuhiro Chiba; Eugene Thonar; Kern Singh; Koichi Masuda
Osteogenic protein-1 is most effective in stimulating nucleus pulposus and annulus fibrosus cells to repair their matrix after chondroitinase ABC-induced in vitro chemonucleolysis.
The spine journal : official journal of the North American Spine Society 2005;5(3):231-8.
2005: Stanley H Chia; Mark R Homicz; Barbara L Schumacher; Eugene Thonar; Koichi Masuda; Robert Sah; Deborah Watson
Characterization of human nasal septal chondrocytes cultured in alginate.
Journal of the American College of Surgeons 2005;200(5):691-704.
2005: Yejia Zhang; Howard S An; Marc Toofanfard; Zhen Li; Gunnar B J Andersson; Eugene Thonar
Low-dose interleukin-1 partially counteracts osteogenic protein-1-induced proteoglycan synthesis by adult bovine intervertebral disk cells.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2005;84(5):322-9.
2005: Yoichi Aota; Howard S An; Gene A Homandberg; Eugene Thonar; Gunnar B J Andersson; Rajeswari Pichika; Koichi Masuda
Differential effects of fibronectin fragment on proteoglycan metabolism by intervertebral disc cells: a comparison with articular chondrocytes.
Spine 2005;30(7):722-8.
2005: Howard S An; Kenji Takegami; Hiroshi Kamada; Cahn M Nguyen; Eugene Thonar; Kern Singh; Gunnar B J Andersson; Koichi Masuda
Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits.
Spine 2005;30(1):25-31; discussion 31-2.
2005: Koichi Masuda; Yoichi Aota; Carol Muehleman; Yoshiyuki Imai; Masahiko Okuma; Eugene Thonar; Gunnar B J Andersson; Howard S An
A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration.
Spine 2005;30(1):5-14.
2004: Hafida El Hajjaji; James M Williams; Jean-Pierre Devogelaer; Mary Ellen Lenz; Eugene Thonar; Daniel-Henri Manicourt
Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2004;12(11):904-11.
2004: Yejia Zhang; Howard S An; Shiwen Song; Marc Toofanfard; Koichi Masuda; Gunnar B J Andersson; Eugene Thonar
Growth factor osteogenic protein-1: differing effects on cells from three distinct zones in the bovine intervertebral disc.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2004;83(7):515-21.
2004: Anthony J Aldave; V Yellore; Eugene Thonar; Nitin Udar; John F Warren; Michael K Yoon; Elisabeth J Cohen; Christopher J Rapuano; Peter R Laibson; Todd P Margolis; Kent W Small
Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophy.
American journal of ophthalmology 2004;137(3):465-73.
2004: Stanley H Chia; Barbara L Schumacher; Travis J Klein; Eugene Thonar; Koichi Masuda; Robert Sah; Deborah Watson
Tissue-engineered human nasal septal cartilage using the alginate-recovered-chondrocyte method.
The Laryngoscope 2004;114(1):38-45.
2003: John F Warren; Anthony J Aldave; Muthaiah Srinivasan; Eugene Thonar; Abha B Kumar; Vicky Cevallos; John P Whitcher; Todd P Margolis
Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India.
Archives of ophthalmology 2003;121(11):1608-12.
2003: Koichi Masuda; Kenji Takegami; H An; F Kumano; K Chiba; Gunnar B J Andersson; Thomas M Schmid; Eugene Thonar
Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(5):922-30.
2003: Amanda K Williamson; Albert C Chen; Koichi Masuda; Eugene Thonar; Robert Sah
Tensile mechanical properties of bovine articular cartilage: variations with growth and relationships to collagen network components.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(5):872-80.
2003: Amanda K Williamson; Koichi Masuda; Eugene Thonar; Robert Sah
Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties.
Tissue engineering 2003;9(4):625-34.
2003: Howard S An; Eugene Thonar; Koichi Masuda
Biological repair of intervertebral disc.
Spine 2003;28(15 Suppl):S86-92.
2003: Travis J Klein; Barbara L Schumacher; Tannin A Schmidt; Kelvin W Li; Michael S Voegtline; Koichi Masuda; Eugene Thonar; Robert Sah
Tissue engineering of stratified articular cartilage from chondrocyte subpopulations.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(8):595-602.
2003: James M Williams; Vineeta Rayan; Dale R Sumner; Eugene Thonar
The use of intra-articular Na-hyaluronate as a potential chondroprotective device in experimentally induced acute articular cartilage injury and repair in rabbits.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(2):305-11.
2003: Mark R Homicz; Stanley H Chia; Barbara L Schumacher; Koichi Masuda; Eugene Thonar; Robert Sah; Deborah Watson
Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture.
The Laryngoscope 2003;113(1):25-32.
2003: Koichi Masuda; Robert Sah; Michael J Hejna; Eugene Thonar
A novel two-step method for the formation of tissue-engineered cartilage by mature bovine chondrocytes: the alginate-recovered-chondrocyte (ARC) method.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(1):139-48.
2002: Hiroshi Kamada; Koichi Masuda; Aloma L D'Souza; Mary Ellen Lenz; Daniel Pietryla; Lori Otten; Eugene Thonar
Age-related differences in the accumulation and size of hyaluronan in alginate culture.
Archives of biochemistry and biophysics 2002;408(2):192-9.
2002: Eugene Thonar; H An; Koichi Masuda
Compartmentalization of the matrix formed by nucleus pulposus and annulus fibrosus cells in alginate gel.
Biochemical Society transactions 2002;30(Pt 6):874-8.
2002: Gabriella Cs-Szabo; Deborah Ragasa-San Juan; Vani Turumella; Koichi Masuda; Eugene Thonar; Howard S An
Changes in mRNA and protein levels of proteoglycans of the anulus fibrosus and nucleus pulposus during intervertebral disc degeneration.
Spine 2002;27(20):2212-9.
2002: Kenji Takegami; Eugene Thonar; Howard S An; Hiroshi Kamada; Koichi Masuda
Osteogenic protein-1 enhances matrix replenishment by intervertebral disc cells previously exposed to interleukin-1.
Spine 2002;27(12):1318-25.
2002: Abid A Qureshi; Amarjit S Virdi; Michael L Didonna; Joshua J Jacobs; Koichi Masuda; Wayne P Paprosky; Eugene Thonar; Dale R Sumner
Implant design affects markers of bone resorption and formation in total hip replacement.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(5):800-7.
2002: Carol Muehleman; J Green; James M Williams; Klaus E Kuettner; Eugene Thonar; Dale R Sumner
The effect of bone remodeling inhibition by zoledronic acid in an animal model of cartilage matrix damage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):226-33.
2000: PM Ragan; V I Chin; Han-Hwa Hung; K Masuda; Eugene Thonar; Elizabeth C Arner; Alan J Grodzinsky; John D Sandy
Chondrocyte extracellular matrix synthesis and turnover are influenced by static compression in a new alginate disk culture system.
Archives of biochemistry and biophysics 2000;383(2):256-64.
2000: Tomoya O Akama; Kohji Nishida; Jun Nakayama; H Watanabe; K Ozaki; T Nakamura; A Dota; S Kawasaki; Y Inoue; N Maeda; S Yamamoto; T Fujiwara; Eugene Thonar; Y Shimomura; S Kinoshita; Akira Tanigami; Michiko N Fukuda
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.
Nature genetics 2000;26(2):237-41.
2000: Yoshihiro Nishida; Aloma L D'Souza; Eugene Thonar; Warren Knudson
Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage.
Arthritis and rheumatism 2000;43(6):1315-26.
2000: Daniel-Henri Manicourt; P Poilvache; A Van Egeren; Jean-Pierre Devogelaer; Mary Ellen Lenz; Eugene Thonar
Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis.
Arthritis and rheumatism 2000;43(2):281-8.
2000: Aloma L D'Souza; Koichi Masuda; Lori Otten; Yoshihiro Nishida; Warren Knudson; Eugene Thonar
Differential effects of interleukin-1 on hyaluronan and proteoglycan metabolism in two compartments of the matrix formed by articular chondrocytes maintained in alginate.
Archives of biochemistry and biophysics 2000;374(1):59-65.
1999: Daniel-Henri Manicourt; P Poilvache; Adrien Nzeusseu; A van Egeren; Jean-Pierre Devogelaer; Mary Ellen Lenz; Eugene Thonar
Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest.
Arthritis and rheumatism 1999;42(9):1861-9.
1999: Daniel-Henri Manicourt; R D Altman; James M Williams; Jean-Pierre Devogelaer; A Druetz-Van Egeren; Mary Ellen Lenz; Daniel Pietryla; Eugene Thonar
Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions.
Arthritis and rheumatism 1999;42(6):1159-67.
1999: Eugene Thonar
Molecular markers of metabolic changes in osteoarthritis.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1999;7(3):338-9.
1998: L Stefan Lohmander; L Dahlberg; David R Eyre; Michael W Lark; Eugene Thonar; Leif Ryd
Longitudinal and cross-sectional variability in markers of joint metabolism in patients with knee pain and articular cartilage abnormalities.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(5):351-61.
1998: K Chiba; Gunnar B J Andersson; Koichi Masuda; Shigeki Momohara; J M Williams; Eugene Thonar
A new culture system to study the metabolism of the intervertebral disc in vitro.
Spine 1998;23(17):1821-7; discussion 1828.
1998: Leena Sharma; D E Hurwitz; Eugene Thonar; JA Sum; M E Lenz; Dorothy D Dunlop; Thomas J Schnitzer; G Kirwan-Mellis; Thomas P Andriacchi
Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis.
Arthritis and rheumatism 1998;41(7):1233-40.
1998: Daniel Uebelhart; Eugene Thonar; P D Delmas; Alex Chantraine; Eric Vignon
Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6 Suppl A():39-46.
1998: Daniel Uebelhart; Eugene Thonar; J Zhang; J M Williams
Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6 Suppl A():6-13.
1998: V Rayan; Eugene Thonar; L M Chen; M E Lenz; James M Williams
Regional differences in the rise in blood levels of antigenic keratan sulfate and hyaluronan after chymopapain induced knee joint injury.
The Journal of rheumatology 1998;25(3):521-6.
1998: Peter Clausen; Eugene Thonar; Juergen Mollenhauer; J Flechtenmacher
Culture of chondrocytes in alginate gel: variations in conditions of gelation influence the structure of the alginate gel, and the arrangement and morphology of proliferating chondrocytes.
In vitro cellular & developmental biology. Animal 1998;34(2):123-30.
1997: K Chiba; Gunnar B J Andersson; K Masuda; Eugene Thonar
Metabolism of the extracellular matrix formed by intervertebral disc cells cultured in alginate.
Spine 1997;22(24):2885-93.
1997: Klaus Huch; berry wilbrink; J Flechtenmacher; Holger E Koepp; MB Aydelotte; T K Sampath; Klaus E Kuettner; Juergen Mollenhauer; Eugene Thonar
Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1beta.
Arthritis and rheumatism 1997;40(12):2157-61.
1997: Andrew J Quantock; G K Klintworth; David J Schanzlin; M E Lenz; Eugene Thonar
Proteoglycans contain a 4.6-A repeat in corneas with macular dystrophy: II. Histochemical evidence.
Cornea 1997;16(3):322-6.
1997: Vkadimir Vilim; M E Lenz; R Vytasek; K Masuda; K Pavelka; K E Kuettner; Eugene Thonar
Characterization of monoclonal antibodies recognizing different fragments of cartilage oligomeric matrix protein in human body fluids.
Archives of biochemistry and biophysics 1997;341(1):8-16.
1997: Andrew J Quantock; Nigel J Fullwood; Eugene Thonar; S R Waltman; M S Capel; M Ito; SM Verity; David J Schanzlin
Macular corneal dystrophy type II: multiple studies on a cornea with low levels of sulphated keratan sulphate.
Eye (London, England) 1997;11 ( Pt 1)():57-67.
1996: J Flechtenmacher; Klaus Huch; Eugene Thonar; Juergen Mollenhauer; S R Davies; Thomas M Schmid; W Puhl; T K Sampath; MB Aydelotte; Klaus E Kuettner
Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes.
Arthritis and rheumatism 1996;39(11):1896-904.
1996: Hans Jörg Häuselmann; K Masuda; E B Hunziker; Michel Neidhart; S S Mok; Beat A Michel; Eugene Thonar
Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage.
The American journal of physiology 1996;271(3 Pt 1):C742-52.
1996: J C Meyer; Andrew J Quantock; Eugene Thonar; M C Kincaid; Gregory S Hageman; KK Assil
Characterization of a central corneal cloudiness sharing features of posterior crocodile shagreen and central cloud dystrophy of François.
Cornea 1996;15(4):347-54.
1996: Fridbert Jonasson; E Oshima; Eugene Thonar; C F Smith; J H Johannsson; Gordon K Klintworth
Macular corneal dystrophy in Iceland. A clinical, genealogic, and immunohistochemical study of 28 patients.
Ophthalmology 1996;103(7):1111-7.
1996: B Petit; K Masuda; A L D'Souza; L Otten; D Pietryla; D J Hartmann; N P Morris; D Uebelhart; Thomas M Schmid; Eugene Thonar
Characterization of crosslinked collagens synthesized by mature articular chondrocytes cultured in alginate beads: comparison of two distinct matrix compartments.
Experimental cell research 1996;225(1):151-61.
1996: Andrew J Quantock; G K Klintworth; David J Schanzlin; M S Capel; M E Lenz; Eugene Thonar
Proteoglycans contain a 4.6 A repeat in muscular dystrophy corneas: x-ray diffraction evidence.
Biophysical journal 1996;70(4):1966-72.
1996: H J Hauselmann; J Flechtenmacher; L Michal; Eugene Thonar; M Shinmei; Klaus E Kuettner; MB Aydelotte
The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers.
Arthritis and rheumatism 1996;39(3):478-88.
1996: Y Koyano; M Hejna; J Flechtenmacher; Thomas M Schmid; Eugene Thonar; Juergen Mollenhauer
Collagen and proteoglycan production by bovine fetal and adult chondrocytes under low levels of calcium and zinc ions.
Connective tissue research 1996;34(3):213-25.
1996: James M Williams; D Uebelhart; Eugene Thonar; K Kocsis; L Módis
Alteration and recovery of the spatial orientation of the collagen network of articular cartilage in adolescent rabbits following intra-articular chymopapain injection.
Connective tissue research 1996;34(2):105-17.
1995: Eugene Thonar; K Masuda; Hans Jörg Häuselmann; D Uebelhart; Mary Ellen Lenz; Daniel-Henri Manicourt
Keratan sulfate in body fluids in joint disease.
Acta orthopaedica Scandinavica. Supplementum 1995;266():103-6.
1995: D H Manicourt; N Fujimoto; K Obata; Eugene Thonar
Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum levels of antigenic keratan sulfate and systemic parameters of inflammation.
Arthritis and rheumatism 1995;38(8):1031-9.
1995: Mohammed Sharif; E George; L Shepstone; W Knudson; Eugene Thonar; J Cushnaghan; Paul Dieppe
Serum hyaluronic acid level as a predictor of disease progression in osteoarthritis of the knee.
Arthritis and rheumatism 1995;38(6):760-7.
1995: HP Roos; L Dahlberg; L A Hoerrner; Michael W Lark; Eugene Thonar; M Shinmei; U Lindqvist; L Stefan Lohmander
Markers of cartilage matrix metabolism in human joint fluid and serum: the effect of exercise.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1995;3(1):7-14.
1995: Eugene Thonar; K Masuda; Mary Ellen Lenz; H J Hauselmann; Klaus E Kuettner; Daniel-Henri Manicourt
Serum markers of systemic disease processes in osteoarthritis.
The Journal of rheumatology. Supplement 1995;43():68-70.
1995: Daniel-Henri Manicourt; O Cornu; Mary Ellen Lenz; A Druetz-van Egeren; Eugene Thonar
Rapid and sustained rise in the serum level of hyaluronan after anterior cruciate ligament transection in the dog knee joint.
The Journal of rheumatology 1995;22(2):262-9.
1995: M M París; IR Friedland; S Ehrett; S M Hickey; K D Olsen; E Hansen; Eugene Thonar; George H McCracken
Effect of interleukin-1 receptor antagonist and soluble tumor necrosis factor receptor in animal models of infection.
The Journal of infectious diseases 1995;171(1):161-9.
1994: S S Mok; K Masuda; Hans Jörg Häuselmann; MB Aydelotte; Eugene Thonar
Aggrecan synthesized by mature bovine chondrocytes suspended in alginate. Identification of two distinct metabolic matrix pools.
The Journal of biological chemistry 1994;269(52):33021-7.
1994: N Ishiguro; Eugene Thonar; D Uebelhart; James M Williams
Immunolocalization of atypical chondroitin sulfate chains in rabbit articular cartilage after chymopapain-induced injury.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1994;2(4):285-8.
1994: D H Manicourt; N Fujimoto; K Obata; Eugene Thonar
Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis.
Arthritis and rheumatism 1994;37(12):1774-83.
1994: Eugene Thonar; Daniel-Henri Manicourt
[Biological markers of osteoarthritis].
Revue du rhumatisme (Ed. française : 1993) 1994;61(9 Pt 2):99S-102S.
1994: James M Williams; M Moran; Eugene Thonar; R B Salter
Continuous passive motion stimulates repair of rabbit knee articular cartilage after matrix proteoglycan loss.
Clinical orthopaedics and related research 1994;(304):252-62.
1994: B Haraoui; Eugene Thonar; Johanne Martel-Pelletier; J R Goulet; Jean-Pierre Raynauld; M Ouellet; Jean-Pierre Pelletier
Serum keratan sulfate levels in rheumatoid arthritis: inverse correlation with radiographic staging.
The Journal of rheumatology 1994;21(5):813-7.
1994: A Kahn; Lawrence Pottenger; J G Albertini; A D Taitz; Eugene Thonar
Chemical stabilization of cartilage matrix.
The Journal of surgical research 1994;56(4):302-8.
1994: D P Kiester; J M Williams; Gunnar B J Andersson; Eugene Thonar; T W McNeill
The dose-related effect of intradiscal chymopapain on rabbit intervertebral discs.
Spine 1994;19(7):747-51.
1994: K Masuda; H Shirota; Eugene Thonar
Quantification of 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates.
Analytical biochemistry 1994;217(2):167-75.
1994: Hans Jörg Häuselmann; R J Fernandes; S S Mok; Thomas M Schmid; J A Block; MB Aydelotte; Klaus E Kuettner; Eugene Thonar
Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads.
Journal of cell science 1994;107 ( Pt 1)():17-27.
1993: James M Williams; D R Ongchi; Eugene Thonar
Repair of articular cartilage injury following intra-articular chymopapain-induced matrix proteoglycan loss.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1993;11(5):705-16.
1993: Eugene Thonar; M Shinmei; L S Lohmander
Body fluid markers of cartilage changes in osteoarthritis.
Rheumatic diseases clinics of North America 1993;19(3):635-57.
1993: D Uebelhart; Eugene Thonar; D W Pietryla; James M Williams
Elevation in urinary levels of pyridinium cross-links of collagen following chymopapain-induced degradation of articular cartilage in the rabbit knee provides evidence of metabolic changes in bone.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1993;1(3):185-92.
1993: D H Manicourt; R Triki; K Fukuda; J P Devogelaer; C Nagant de Deuxchaisnes; Eugene Thonar
Levels of circulating tumor necrosis factor alpha and interleukin-6 in patients with rheumatoid arthritis. Relationship to serum levels of hyaluronan and antigenic keratan sulfate.
Arthritis and rheumatism 1993;36(4):490-9.
1993: Andrew J Quantock; Keith M Meek; Eugene Thonar; KK Assil
Synchrotron X-ray diffraction in atypical macular dystrophy.
Eye (London, England) 1993;7 ( Pt 6)():779-84.
1992: Eugene Thonar; Tibor T Glant
Serum keratan sulfate--a marker of predisposition to polyarticular osteoarthritis.
Clinical biochemistry 1992;25(3):175-80.
1992: Andrew J Quantock; Keith M Meek; Eugene Thonar
Analysis of high-angle synchrotron x-ray diffraction patterns obtained from macular dystrophy corneas.
Cornea 1992;11(3):185-90.
1992: M B Sweet; I Jakim; A Coelho; P J Becker; Eugene Thonar
Serum keratan sulfate levels in marathon runners.
International journal of sports medicine 1992;13(4):348-50.
1992: Hans Jörg Häuselmann; MB Aydelotte; B L Schumacher; Klaus E Kuettner; S H Gitelis; Eugene Thonar
Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads.
Matrix (Stuttgart, Germany) 1992;12(2):116-29.
1992: Tibor T Glant; Katalin Mikecz; RR Bartlett; F Deák; Eugene Thonar; J M Williams; T Mattar; Klaus E Kuettner; R Schleyerbach
Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide.
Immunopharmacology 1992;23(2):105-16.
1991: Daniel-Henri Manicourt; Mary Ellen Lenz; Eugene Thonar
Levels of serum keratan sulfate rise rapidly and remain elevated following anterior cruciate ligament transection in the dog.
The Journal of rheumatology 1991;18(12):1872-6.
1991: G V Campion; F McCrae; Thomas J Schnitzer; Mary Ellen Lenz; Paul Dieppe; Eugene Thonar
Levels of keratan sulfate in the serum and synovial fluid of patients with osteoarthritis of the knee.
Arthritis and rheumatism 1991;34(10):1254-9.
1991: R L Goldberg; J P Huff; Mary Ellen Lenz; P Glickman; R Katz; Eugene Thonar
Elevated plasma levels of hyaluronate in patients with osteoarthritis and rheumatoid arthritis.
Arthritis and rheumatism 1991;34(7):799-807.
1991: Klaus E Kuettner; MB Aydelotte; Eugene Thonar
Articular cartilage matrix and structure: a minireview.
The Journal of rheumatology. Supplement 1991;27():46-8.
1991: Eugene Thonar; D M Manicourt; J Williams; Mary Ellen Lenz; M B Sweet; Thomas J Schnitzer; L Otten; Tibor T Glant; Klaus E Kuettner
Circulating keratan sulfate: a marker of cartilage proteoglycan catabolism in osteoarthritis.
The Journal of rheumatology. Supplement 1991;27():24-6.
1991: J Barone-Varelas; Thomas J Schnitzer; Q Meng; L Otten; Eugene Thonar
Age-related differences in the metabolism of proteoglycans in bovine articular cartilage explants maintained in the presence of insulin-like growth factor I.
Connective tissue research 1991;26(1-2):101-20.
1991: D H Manicourt; J C Pita; Eugene Thonar; David S Howell
Proteoglycans nondissociatively extracted from different zones of canine normal articular cartilage: variations in the sedimentation profile of aggregates with degree of physiological stress.
Connective tissue research 1991;26(4):231-46.
1991: Andrew J Quantock; Keith M Meek; P Brittain; AE Ridgway; Eugene Thonar
Alteration of the stromal architecture and depletion of keratan sulphate proteoglycans in oedematous human corneas: histological, immunochemical and X-ray diffraction evidence.
Tissue & cell 1991;23(5):593-606.
1990: M B Sweet; I Jakim; A Coelho; P J Becker; Eugene Thonar
Serum keratan sulphate levels during prolonged rest.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1990;78(11):629-30.
1990: Eugene Thonar
Serum keratan sulfate concentration as a measure of the catabolism of cartilage proteoglycans.
Ryūmachi. [Rheumatism] 1990;30(6):461-8.
1990: R J Midura; Vincent C Hascall; D K MacCallum; R F Meyer; Eugene Thonar; J R Hassell; C F Smith; G K Klintworth
Proteoglycan biosynthesis by human corneas from patients with types 1 and 2 macular corneal dystrophy.
The Journal of biological chemistry 1990;265(26):15947-55.
1990: Deepak P Edward; Eugene Thonar; M Srinivasan; Beatrice Y J T Yue; Mark O M Tso
Macular dystrophy of the cornea. A systemic disorder of keratan sulfate metabolism.
Ophthalmology 1990;97(9):1194-200.
1990: Andrew J Quantock; Keith M Meek; AE Ridgway; A J Bron; Eugene Thonar
Macular corneal dystrophy: reduction in both corneal thickness and collagen interfibrillar spacing.
Current eye research 1990;9(4):393-8.
1990: Lauren M Pachman; O C Green; Mary Ellen Lenz; JR Hayford; Eugene Thonar
Increase in serum concentration of keratan sulfate after treatment of growth hormone deficiency with growth hormone.
The Journal of pediatrics 1990;116(3):400-3.
1990: Juergen Mollenhauer; N Müller; Eugene Thonar
[New approaches in laboratory diagnosis of osteoarthritis].
Der Orthopäde 1990;19(1):28-35.
1989: Keith M Meek; Andrew J Quantock; G F Elliott; AE Ridgway; A B Tullo; A J Bron; Eugene Thonar
Macular corneal dystrophy: the macromolecular structure of the stroma observed using electron microscopy and synchrotron X-ray diffraction.
Experimental eye research 1989;49(6):941-58.
1989: Klaus E Kuettner; Eugene Thonar; MB Aydelotte
Metabolism of articular cartilage chondrocytes.
Nihon Seikeigeka Gakkai zasshi 1989;63(5):621-9.
1989: K D Brandt; Eugene Thonar
Lack of association between serum keratan sulfate concentrations and cartilage changes of osteoarthritis after transection of the anterior cruciate ligament in the dog.
Arthritis and rheumatism 1989;32(5):647-51.
1989: Michiko N Fukuda; K A Masri; A Dell; Eugene Thonar; G Klier; Raymond Lowenthal
Defective glycosylation of erythrocyte membrane glycoconjugates in a variant of congenital dyserythropoietic anemia type II: association of low level of membrane-bound form of galactosyltransferase.
Blood 1989;73(5):1331-9.
1989: J A Williams; Eugene Thonar
Early osteophyte formation after chemically induced articular cartilage injury.
The American journal of sports medicine 1989;17(1):7-15.
1989: X Q Li; Eugene Thonar; Warren Knudson
Accumulation of hyaluronate in human lung carcinoma as measured by a new hyaluronate ELISA.
Connective tissue research 1989;19(2-4):243-53.
1989: K E Kuettner; Eugene Thonar; MB Aydelotte
Modern aspects of articular cartilage biochemistry.
Verhandlungen der Deutschen Gesellschaft für Innere Medizin 1989;95():436-47.
1989: D H Manicourt; Eugene Thonar; J C Pita; David S Howell
Changes in the sedimentation profile of proteoglycan aggregates in early experimental canine osteoarthritis.
Connective tissue research 1989;23(1):33-50.
1989: J A Block; Thomas J Schnitzer; Gunnar B J Andersson; Mary Ellen Lenz; R Jeffery; T W McNeill; Eugene Thonar
The effect of chemonucleolysis on serum keratan sulfate levels in humans.
Arthritis and rheumatism 1989;32(1):100-4.
1988: Deepak P Edward; Beatrice Y J T Yue; Joel Sugar; Eugene Thonar; N SunderRaj; E L Stock; Mark O M Tso
Heterogeneity in macular corneal dystrophy.
Archives of ophthalmology 1988;106(11):1579-83.
1988: C J Yang; N SundarRaj; Eugene Thonar; Gordon K Klintworth
Immunohistochemical evidence of heterogeneity in macular corneal dystrophy.
American journal of ophthalmology 1988;106(1):65-71.
1988: Theodore R Oegema; S M Swedenburg; David S Bradford; Eugene Thonar
Levels of keratan sulfate-bearing fragments rise predictably following chemonucleolysis of dog intervertebral discs with chymopapain.
Spine 1988;13(6):707-11.
1988: M B Sweet; A Coelho; CM Schnitzler; Thomas J Schnitzer; Mary Ellen Lenz; I Jakim; Klaus E Kuettner; Eugene Thonar
Serum keratan sulfate levels in osteoarthritis patients.
Arthritis and rheumatism 1988;31(5):648-52.
1988: James M Williams; C Downey; Eugene Thonar
Increase in levels of serum keratan sulfate following cartilage proteoglycan degradation in the rabbit knee joint.
Arthritis and rheumatism 1988;31(4):557-60.
1988: James M Williams; R J Katz; D Childs; M E Lenz; Eugene Thonar
Keratan sulfate content in the superficial and deep layers of osteophytic and nonfibrillated human articular cartilage in osteoarthritis.
Calcified tissue international 1988;42(3):162-6.
1988: Eugene Thonar; Lauren M Pachman; Mary Ellen Lenz; JR Hayford; P Lynch; Klaus E Kuettner
Age related changes in the concentration of serum keratan sulphate in children.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1988;26(2):57-63.
1988: Eugene Thonar; S B Feist; K Fassbender; Mary Ellen Lenz; B L Matijevitch; Klaus E Kuettner
Quantification of hen egg white lysozyme in cartilage by an enzyme-linked immunosorbent assay.
Connective tissue research 1988;17(3):181-97.
1988: KG Vogel; Eugene Thonar
Keratan sulfate is a component of proteoglycans in the compressed region of adult bovine flexor tendon.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(3):434-42.
1987: D J Kliner; J P Gorski; Eugene Thonar
Keratan sulfate levels in sera of patients bearing cartilage tumors.
Cancer 1987;59(11):1931-5.
1987: Eugene Thonar; T J Schnitzer; K E Kuettner
Quantification of keratan sulfate in blood as a marker of cartilage catabolism.
The Journal of rheumatology 1987;14 Spec No():23-4.
1987: J H Kimura; T Shinomura; Eugene Thonar
Biosynthesis of cartilage proteoglycan and link protein.
Methods in enzymology 1987;144():372-93.
1986: G K Klintworth; R Meyer; R Dennis; A T Hewitt; E L Stock; Mary Ellen Lenz; J R Hassell; Walter J Stark; Klaus E Kuettner; Eugene Thonar
Macular corneal dystrophy. Lack of keratan sulfate in serum and cornea.
Ophthalmic paediatrics and genetics 1986;7(3):139-43.
1986: Eugene Thonar; R F Meyer; R F Dennis; Mary Ellen Lenz; B Maldonado; J R Hassell; A T Hewitt; Walter J Stark; E L Stock; Klaus E Kuettner
Absence of normal keratan sulfate in the blood of patients with macular corneal dystrophy.
American journal of ophthalmology 1986;102(5):561-9.
1986: C E Dinsmore; R J Goss; M E Lenz; Eugene Thonar
Correlations between phases of deer antler regeneration and levels of serum keratan sulfate.
Calcified tissue international 1986;39(4):244-7.
1986: Eugene Thonar; J A Buckwalter; K E Kuettner
Maturation-related differences in the structure and composition of proteoglycans synthesized by chondrocytes from bovine articular cartilage.
The Journal of biological chemistry 1986;261(5):2467-74.
1986: C Arsenis; Eugene Thonar; Klaus E Kuettner
Degradation of cartilage matrix by purified elastase and its control by an endogenous purified specific cartilage elastase inhibitor.
Agents and actions. Supplements 1986;18():63-8.
1985: Eugene Thonar; Mary Ellen Lenz; G K Klintworth; B Caterson; Lauren M Pachman; P Glickman; R Katz; J Huff; Klaus E Kuettner
Quantification of keratan sulfate in blood as a marker of cartilage catabolism.
Arthritis and rheumatism 1985;28(12):1367-76.
1985: J A Buckwalter; K E Kuettner; Eugene Thonar
Age-related changes in articular cartilage proteoglycans: electron microscopic studies.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1985;3(3):251-7.
1983: Eugene Thonar; L S Lohmander; J H Kimura; S A Fellini; M Yanagishita; V C Hascall
Biosynthesis of O-linked oligosaccharides on proteoglycans by chondrocytes from the swarm rat chondrosarcoma.
The Journal of biological chemistry 1983;258(19):11564-70.
1983: B U Pauli; D E Schwartz; Eugene Thonar; K E Kuettner
Tumor invasion and host extracellular matrix.
Cancer metastasis reviews 1983;2(2):129-52.
1982: Eugene Thonar; J H Kimura; V C Hascall; A R Poole
Enzyme-linked immunosorbent assay analyses of the hyaluronate-binding region and the link protein of proteoglycan aggregate.
The Journal of biological chemistry 1982;257(23):14173-80.
1982: K E Kuettner; V A Memoli; B U Pauli; N C Wrobel; Eugene Thonar; Jon Daniel
Synthesis of cartilage matrix by mammalian chondrocytes in vitro. II. Maintenance of collagen and proteoglycan phenotype.
The Journal of cell biology 1982;93(3):751-7.
1982: K Kimata; J H Kimura; Eugene Thonar; H J Barrach; S I Rennard; V C Hascall
Swarm rat chondrosarcoma proteoglycans. Purification of aggregates by zonal centrifugation of preformed cesium sulfate gradients.
The Journal of biological chemistry 1982;257(7):3819-26.