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David Stokoe

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Prados Michael D; Chang Susan M; Butowski Nicholas; DeBoer Rebecca; Parvataneni Rupa; Carliner Hannah; Kabuubi Paul; Ayers-Ringler Jennifer; Rabbitt Jane; Page Margaretta; Fedoroff Anne; Sneed Penny K; Berger Mitchel S; McDermott Michael W; Parsa Andrew T; Vandenberg Scott; James C David; Lamborn Kathleen R; Stokoe David; Haas-Kogan Daphne A
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma.
Ermoian Ralph P; Kaprealian Tania; Lamborn Kathleen R; Yang Xiaodong; Jelluma Nannette; Arvold Nils D; Zeidman Ruth; Berger Mitchel S; Stokoe David; Haas-Kogan Daphne A
Signal transduction molecules in gliomas of all grades.
Fan Qi-Wen; Cheng Christine; Knight Zachary A; Haas-Kogan Daphne; Stokoe David; James C David; McCormick Frank; Shokat Kevan M; Weiss William A
EGFR signals to mTOR through PKC and independently of Akt in glioma.

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2009: Prados Michael D; Chang Susan M; Butowski Nicholas; DeBoer Rebecca; Parvataneni Rupa; Carliner Hannah; Kabuubi Paul; Ayers-Ringler Jennifer; Rabbitt Jane; Page Margaretta; Fedoroff Anne; Sneed Penny K; Berger Mitchel S; McDermott Michael W; Parsa Andrew T; Vandenberg Scott; James C David; Lamborn Kathleen R; Stokoe David; Haas-Kogan Daphne A
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(4):579-84.
2009: Ermoian Ralph P; Kaprealian Tania; Lamborn Kathleen R; Yang Xiaodong; Jelluma Nannette; Arvold Nils D; Zeidman Ruth; Berger Mitchel S; Stokoe David; Haas-Kogan Daphne A
Signal transduction molecules in gliomas of all grades.
Journal of neuro-oncology 2009;91(1):19-26.
2009: Fan Qi-Wen; Cheng Christine; Knight Zachary A; Haas-Kogan Daphne; Stokoe David; James C David; McCormick Frank; Shokat Kevan M; Weiss William A
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science signaling 2009;2(55):ra4.
2008: Oda Katsutoshi; Okada Jennifer; Timmerman Luika; Rodriguez-Viciana Pablo; Stokoe David; Shoji Keiko; Taketani Yuji; Kuramoto Hiroyuki; Knight Zachary A; Shokat Kevan M; McCormick Frank
PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.
Cancer research 2008;68(19):8127-36.
2008: Torbett Neil E; Luna-Moran Antonio; Knight Zachary A; Houk Andrew; Moasser Mark; Weiss William; Shokat Kevan M; Stokoe David
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
The Biochemical journal 2008;415(1):97-110.
2008: Tamgüney Tanja; Zhang Chao; Fiedler Dorothea; Shokat Kevan; Stokoe David
Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Experimental cell research 2008;314(11-12):2299-312.
2008: Gräub Remo; Lancero Hope; Pedersen Anissa; Chu Meihua; Padmanabhan Krishnan; Xu Xiao-Qin; Spitz Paul; Chalkley Robert; Burlingame Alma L; Stokoe David; Bernstein Harold S
Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.
Cell cycle (Georgetown, Tex.) 2008;7(12):1795-803.
2008: Haas-Kogan Daphne; Stokoe David
PTEN in brain tumors.
Expert review of neurotherapeutics 2008;8(4):599-610.
2008: Chen Jack S; Zhou Linda J; Entin-Meer Michal; Yang Xiaodong; Donker Mila; Knight Zachary A; Weiss William; Shokat Kevan M; Haas-Kogan Daphne; Stokoe David
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma.
Molecular cancer therapeutics 2008;7(4):841-50.
2007: Tamguney Tanja; Stokoe David
New insights into PTEN.
Journal of cell science 2007;120(Pt 23):4071-9.
2007: Bilanges B; Stokoe D
Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies.
Oncogene 2007;26(41):5973-90.
2007: Bilanges Benoit; Argonza-Barrett Rhoda; Kolesnichenko Marina; Skinner Christina; Nair Manoj; Chen Michelle; Stokoe David
Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.
Molecular and cellular biology 2007;27(16):5746-64.
2007: Wiencke John K; Zheng Shichun; Jelluma Nanette; Tihan Tarik; Vandenberg Scott; Tamgüney Tanja; Baumber Rachel; Parsons Ramon; Lamborn Kathleen R; Berger Mitchel S; Wrensch Margaret R; Haas-Kogan Daphne Adele; Stokoe David
Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma.
Neuro-oncology 2007;9(3):271-9.
2007: Parsa Andrew T; Waldron James S; Panner Amith; Crane Courtney A; Parney Ian F; Barry Jeffrey J; Cachola Kristine E; Murray Joseph C; Tihan Tarik; Jensen Michael C; Mischel Paul S; Stokoe David; Pieper Russell O
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma.
Nature medicine 2007;13(1):84-8.
2007: Fujii Naoaki; Haresco Jose J; Novak Kathleen A P; Gage Robert M; Pedemonte Nicoletta; Stokoe David; Kuntz Irwin D; Guy R Kiplin
Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.
Bioorganic & medicinal chemistry letters 2007;17(2):549-52.
2006: Panner Amith; Nakamura Jean L; Parsa Andrew T; Rodriguez-Viciana Pablo; Berger Mitchel S; Stokoe David; Pieper Russell O
mTOR-independent translational control of the extrinsic cell death pathway by RalA.
Molecular and cellular biology 2006;26(20):7345-57.
2006: Fan Qi-Wen; Knight Zachary A; Goldenberg David D; Yu Wei; Mostov Keith E; Stokoe David; Shokat Kevan M; Weiss William A
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer cell 2006;9(5):341-9.
2006: Jelluma Nannette; Yang Xiaodong; Stokoe David; Evan Gerard I; Dansen Tobias B; Haas-Kogan Daphne A
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes.
Molecular cancer research : MCR 2006;4(5):319-30.
2006: Knight Zachary A; Gonzalez Beatriz; Feldman Morri E; Zunder Eli R; Goldenberg David D; Williams Olusegun; Loewith Robbie; Stokoe David; Balla Andras; Toth Balazs; Balla Tamas; Weiss William A; Williams Roger L; Shokat Kevan M
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell 2006;125(4):733-47.
2005: Oda Katsutoshi; Stokoe David; Taketani Yuji; McCormick Frank
High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma.
Cancer research 2005;65(23):10669-73.
2005: Mellinghoff Ingo K; Wang Maria Y; Vivanco Igor; Haas-Kogan Daphne A; Zhu Shaojun; Dia Ederlyn Q; Lu Kan V; Yoshimoto Koji; Huang Julie H Y; Chute Dennis J; Riggs Bridget L; Horvath Steve; Liau Linda M; Cavenee Webster K; Rao P Nagesh; Beroukhim Rameen; Peck Timothy C; Lee Jeffrey C; Sellers William R; Stokoe David; Prados Michael; Cloughesy Timothy F; Sawyers Charles L; Mischel Paul S
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
The New England journal of medicine 2005;353(19):2012-24.
2005: Gottschalk Alexander R; Doan Albert; Nakamura Jean L; Stokoe David; Haas-Kogan Daphne A
Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism.
International journal of radiation oncology, biology, physics 2005;63(4):1221-7.
2005: Huang Guiqing; Krig Sheryl; Kowbel David; Xu Hongmei; Hyun Bill; Volik Stas; Feuerstein Burt; Mills Gordon B; Stokoe David; Yaswen Paul; Collins Colin
ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.
Human molecular genetics 2005;14(21):3219-25.
2005: Haas-Kogan Daphne A; Prados Michael D; Lamborn Kathleen R; Tihan Tarik; Berger Mitchel S; Stokoe David
Biomarkers to predict response to epidermal growth factor receptor inhibitors.
Cell cycle (Georgetown, Tex.) 2005;4(10):1369-72.
2005: Tominaga Yuichi; Tamgüney Tanja; Kolesnichenko Marina; Bilanges Benoit; Stokoe David
Translational deregulation in PDK-1-/- embryonic stem cells.
Molecular and cellular biology 2005;25(19):8465-75.
2005: O'Shea Clodagh C; Choi Serah; McCormick Frank; Stokoe David
Adenovirus overrides cellular checkpoints for protein translation.
Cell cycle (Georgetown, Tex.) 2005;4(7):883-8.
2005: Haas-Kogan Daphne A; Prados Michael D; Tihan Tarik; Eberhard David A; Jelluma Nannette; Arvold Nils D; Baumber Rachel; Lamborn Kathleen R; Kapadia Ami; Malec Mary; Berger Mitchel S; Stokoe David
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib.
Journal of the National Cancer Institute 2005;97(12):880-7.
2005: Stokoe David
The phosphoinositide 3-kinase pathway and cancer.
Expert reviews in molecular medicine 2005;7(10):1-22.
2005: Bilanges Benoit; Stokoe David
Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.
The Biochemical journal 2005;388(Pt 2):573-83.
2005: O'Shea Clodagh; Klupsch Kristina; Choi Serah; Bagus Bridget; Soria Conrado; Shen Jerry; McCormick Frank; Stokoe David
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.
The EMBO journal 2005;24(6):1211-21.
2005: Gottschalk Alexander R; Doan Albert; Nakamura Jean L; Haas-Kogan Daphne A; Stokoe David
Inhibition of phosphatidylinositol-3-kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent mechanism.
International journal of radiation oncology, biology, physics 2005;61(4):1183-8.
2005: Nakamura Jean L; Karlsson Amelia; Arvold Nils D; Gottschalk Alexander R; Pieper Russell O; Stokoe David; Haas-Kogan Daphne A
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
Journal of neuro-oncology 2005;71(3):215-22.
2005: Stokoe David; Costello Joseph F
Phosphatase and tensin homologue growth suppression without phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2677-8.
2005: Brandts Christian H; Bilanges Benoit; Hare Gregor; McCormick Frank; Stokoe David
Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells.
The Journal of biological chemistry 2005;280(3):2012-9.
2004: Tiffin Nicki; Adi Saleh; Stokoe David; Wu Nan-Yan; Rosenthal Stephen M
Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation.
Endocrinology 2004;145(11):4991-6.
2004: Pore Nabendu; Liu Shuang; Shu Hui-Kuo; Li Bin; Haas-Kogan Daphne; Stokoe David; Milanini-Mongiat Julie; Pages Gilles; O'Rourke Donald M; Bernhard Eric; Maity Amit
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.
Molecular biology of the cell 2004;15(11):4841-53.
2004: Vijapurkar Ulka; Fischbach Neal; Shen Weifang; Brandts Christian; Stokoe David; Lawrence H Jeffrey; Largman Corey
Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation.
Molecular and cellular biology 2004;24(9):3827-37.
2004: Loh Mignon L; Vattikuti Shashaank; Schubbert Suzanne; Reynolds Melissa G; Carlson Elaine; Lieuw Kenneth H; Cheng Jennifer W; Lee Connie M; Stokoe David; Bonifas Jeannette M; Curtiss Nicole P; Gotlib Jason; Meshinchi Soheil; Le Beau Michelle M; Emanuel Peter D; Shannon Kevin M
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis.
Blood 2004;103(6):2325-31.
2003: Hirose Yuichi; Katayama Makoto; Stokoe David; Haas-Kogan Daphne A; Berger Mitchel S; Pieper Russell O
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents.
Molecular and cellular biology 2003;23(22):8306-15.
2003: Fujii Naoaki; Haresco Jose J; Novak Kathleen A P; Stokoe David; Kuntz Irwin D; Guy R Kiplin
A selective irreversible inhibitor targeting a PDZ protein interaction domain.
Journal of the American Chemical Society 2003;125(40):12074-5.
2003: Woodrow Melissa A; Woods Douglas; Cherwinski Holly M; Stokoe David; McMahon Martin
Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway.
Experimental cell research 2003;287(2):325-38.
2003: Stokoe David
Protein phosphorylation drug discovery summit--SRI conference. Targeting kinases and phosphatases for novel therapeutics. 3-5 March 2003, San Diego, CA, USA.
IDrugs : the investigational drugs journal 2003;6(5):432-6.
2003: Gump Jay; Stokoe David; McCormick Frank
Phosphorylation of p16INK4A correlates with Cdk4 association.
The Journal of biological chemistry 2003;278(9):6619-22.
2002: Donovan Shane; See Wendy; Bonifas Jeannette; Stokoe David; Shannon Kevin M
Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells.
Cancer cell 2002;2(6):507-14.
2002: Xu Zheng; Stokoe David; Kane Lawrence P; Weiss Arthur
The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(7):285-96.
2002: Massion Pierre P; Kuo Wen-Lin; Stokoe David; Olshen Adam B; Treseler Patrick A; Chin Koei; Chen Chira; Polikoff Daniel; Jain Ajay N; Pinkel Daniel; Albertson Donna G; Jablons David M; Gray Joe W
Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway.
Cancer research 2002;62(13):3636-40.
2002: Shtivelman Emma; Sussman Joshua; Stokoe David
A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle.
Current biology : CB 2002;12(11):919-24.
2002: Ermoian Ralph P; Furniss Constance S; Lamborn Kathleen R; Basila Daniel; Berger Mitchel S; Gottschalk Alexander R; Nicholas M Kelly; Stokoe David; Haas-Kogan Daphne A
Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1100-6.
2001: Mills G B; Lu Y; Fang X; Wang H; Eder A; Mao M; Swaby R; Cheng K W; Stokoe D; Siminovitch K; Jaffe R; Gray J
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Seminars in oncology 2001;28(5 Suppl 16):125-41.
2001: Sussman J; Stokoe D; Ossina N; Shtivelman E
Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.
The Journal of cell biology 2001;154(5):1019-30.
2001: Stokoe D
PTEN.
Current biology : CB 2001;11(13):R502.
2001: Paz P E; Wang S; Clarke H; Lu X; Stokoe D; Abo A
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
The Biochemical journal 2001;356(Pt 2):461-71.
2001: Gottschalk A R; Basila D; Wong M; Dean N M; Brandts C H; Stokoe D; Haas-Kogan D A
p27Kip1 is required for PTEN-induced G1 growth arrest.
Cancer research 2001;61(5):2105-11.
2000: Flynn P; Wongdagger M; Zavar M; Dean N M; Stokoe D
Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival.
Current biology : CB 2000;10(22):1439-42.
2000: Fang X; Yu S; LaPushin R; Lu Y; Furui T; Penn L Z; Stokoe D; Erickson J R; Bast R C; Mills G B
Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase.
The Biochemical journal 2000;352 Pt 1():135-43.
2000: Taylor V; Wong M; Brandts C; Reilly L; Dean N M; Cowsert L M; Moodie S; Stokoe D
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
Molecular and cellular biology 2000;20(18):6860-71.
2000: Crompton A M; Foley L H; Wood A; Roscoe W; Stokoe D; McCormick F; Symons M; Bollag G
Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands.
The Journal of biological chemistry 2000;275(33):25751-9.
2000: Zundel W; Schindler C; Haas-Kogan D; Koong A; Kaper F; Chen E; Gottschalk A R; Ryan H E; Johnson R S; Jefferson A B; Stokoe D; Giaccia A J
Loss of PTEN facilitates HIF-1-mediated gene expression.
Genes & development 2000;14(4):391-6.
1999: Kane L P; Shapiro V S; Stokoe D; Weiss A
Induction of NF-kappaB by the Akt/PKB kinase.
Current biology : CB 1999;9(11):601-4.
1998: Davies M A; Lu Y; Sano T; Fang X; Tang P; LaPushin R; Koul D; Bookstein R; Stokoe D; Yung W K; Mills G B; Steck P A
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Cancer research 1998;58(23):5285-90.
1998: Haas-Kogan D; Shalev N; Wong M; Mills G; Yount G; Stokoe D
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Current biology : CB 1998;8(21):1195-8.
1998: Bellacosa A; Chan T O; Ahmed N N; Datta K; Malstrom S; Stokoe D; McCormick F; Feng J; Tsichlis P
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
Oncogene 1998;17(3):313-25.
1998: Stephens L; Anderson K; Stokoe D; Erdjument-Bromage H; Painter G F; Holmes A B; Gaffney P R; Reese C B; McCormick F; Tempst P; Coadwell J; Hawkins P T
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.
Science (New York, N.Y.) 1998;279(5351):710-4.
1997: Hawkins P T; Welch H; McGregor A; Eguinoa A; Gobert S; Krugmann S; Anderson K; Stokoe D; Stephens L
Signalling via phosphoinositide 3OH kinases.
Biochemical Society transactions 1997;25(4):1147-51.
1997: Stokoe D; Stephens L R; Copeland T; Gaffney P R; Reese C B; Painter G F; Holmes A B; McCormick F; Hawkins P T
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.
Science (New York, N.Y.) 1997;277(5325):567-70.
1997: Stokoe D; McCormick F
Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro.
The EMBO journal 1997;16(9):2384-96.
1995: Hawkins P T; Eguinoa A; Qiu R G; Stokoe D; Cooke F T; Walters R; Wennström S; Claesson-Welsh L; Evans T; Symons M
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.
Current biology : CB 1995;5(4):393-403.
1994: Stokoe D; Macdonald S G; Cadwallader K; Symons M; Hancock J F
Activation of Raf as a result of recruitment to the plasma membrane.
Science (New York, N.Y.) 1994;264(5164):1463-7.
1993: Stokoe D; Caudwell B; Cohen P T; Cohen P
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.
The Biochemical journal 1993;296 ( Pt 3)():843-9.
1993: Merrall N W; Plevin R J; Stokoe D; Cohen P; Nebreda A R; Gould G W
Mitogen-activated protein kinase (MAP kinase), MAP kinase kinase and c-Mos stimulate glucose transport in Xenopus oocytes.
The Biochemical journal 1993;295 ( Pt 2)():351-5.
1992: Stokoe D; Engel K; Campbell D G; Cohen P; Gaestel M
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
FEBS letters 1992;313(3):307-13.
1992: Stokoe D; Campbell D G; Nakielny S; Hidaka H; Leevers S J; Marshall C; Cohen P
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.
The EMBO journal 1992;11(11):3985-94.
1992: Cohen P; Campbell D G; Dent P; Gomez N; Lavoinne A; Nakielny S; Stokoe D; Sutherland C; Traverse S
Dissection of the protein kinase cascades involved in insulin and nerve growth factor action.
Biochemical Society transactions 1992;20(3):671-4.

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