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Melvin Hayden

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Javad Habibi; Adam Whaley-Connell; Melvin Hayden; Vincent G DeMarco; Rebecca Schneider; Susan D Sowers; Poorna Karuparthi; Carlos M Ferrario; James R Sowers
Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat.
Melvin Hayden; Poorna R Karuparthi; Javad Habibi; Guido Lastra; Kamlesh Patel; Chetan Wasekar; Camila Manrique; Ugur Ozerdem; Sameer Stas; James R Sowers
Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes.
Sonya Addison; Sameer Stas; Melvin Hayden; James R Sowers
Insulin resistance and blood pressure.

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2008: Javad Habibi; Adam Whaley-Connell; Melvin Hayden; Vincent G DeMarco; Rebecca Schneider; Susan D Sowers; Poorna Karuparthi; Carlos M Ferrario; James R Sowers
Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat.
Endocrinology 2008;149(11):5643-53.
2008: Melvin Hayden; Poorna R Karuparthi; Javad Habibi; Guido Lastra; Kamlesh Patel; Chetan Wasekar; Camila Manrique; Ugur Ozerdem; Sameer Stas; James R Sowers
Ultrastructure of islet microcirculation, pericytes and the islet exocrine interface in the HIP rat model of diabetes.
Experimental biology and medicine (Maywood, N.J.) 2008;233(9):1109-23.
2008: Sonya Addison; Sameer Stas; Melvin Hayden; James R Sowers
Insulin resistance and blood pressure.
Current hypertension reports 2008;10(4):319-25.
2008: Adam Whaley-Connell; Javad Habibi; Shawna A Cooper; Vincent G Demarco; Melvin Hayden; Craig S Stump; Daniel Link; Carlos M Ferrario; James R Sowers
Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E103-9.
2008: Guido Lastra; Adam Whaley-Connell; Camila Manrique; Javad Habibi; Alex A Gutweiler; Lama Appesh; Melvin Hayden; Yongzhong Wei; Carlos Ferrario; James R Sowers
Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat.
American journal of physiology. Endocrinology and metabolism 2008;295(1):E110-6.
2008: Vincent G DeMarco; Javad Habibi; Adam Whaley-Connell; Rebecca I Schneider; Randall L Heller; James P Bosanquet; Melvin Hayden; Kimberly Delcour; S A Cooper; Bradley T Andresen; James R Sowers; Kevin Dellsperger
Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2659-68.
2008: Adam Whaley-Connell; Javad Habibi; Ravi Nistala; Shawna A Cooper; Poorna R Karuparthi; Melvin Hayden; Nathan Rehmer; Vincent G DeMarco; Bradley T Andresen; Yongzhong Wei; Carlos M Ferrario; James R Sowers
Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment.
Hypertension 2008;51(2):474-80.
2008: Melvin Hayden; Kamlesh Patel; Javad Habibi; Deepa Gupta; Seema S Tekwani; Adam Whaley-Connell; James R Sowers
Attenuation of endocrine-exocrine pancreatic communication in type 2 diabetes: pancreatic extracellular matrix ultrastructural abnormalities.
Journal of the cardiometabolic syndrome 2008;3(4):234-43.
2008: Melvin Hayden; James R Sowers
Pancreatic renin-angiotensin-aldosterone system in the cardiometabolic syndrome and type 2 diabetes mellitus.
Journal of the cardiometabolic syndrome 2008;3(3):129-31.
2008: Utpal Sen; Thomas P Vacek; William M Hughes; Munish Kumar; Karni S Moshal; Neetu Tyagi; Naira Metreveli; Melvin Hayden; Suresh C Tyagi
Cardioprotective role of sodium thiosulfate on chronic heart failure by modulating endogenous H2S generation.
Pharmacology 2008;82(3):201-13.
2008: Melvin Hayden; David Goldsmith; James R Sowers; Ramesh Khanna
Calciphylaxis: calcific uremic arteriolopathy and the emerging role of sodium thiosulfate.
International urology and nephrology 2008;40(2):443-51.
2008: Melvin Hayden
Homocysteine competes for the peroxisome proliferator-activated receptor nuclear receptors.
Journal of the cardiometabolic syndrome 2008;3(1):70-1.
2008: Melvin Hayden
Calciphylaxis and the cardiometabolic syndrome: the emerging role of sodium thiosulfate as a novel treatment option.
Journal of the cardiometabolic syndrome 2008;3(1):55-9.
2008: Adam Whaley-Connell; Vincent G DeMarco; Guido Lastra; Camila Manrique; Ravi Nistala; Shawna A Cooper; Blair Westerly; Melvin Hayden; Charles E Wiedmeyer; Yongzhong Wei; James R Sowers
Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury.
American journal of nephrology 2008;28(1):67-75.
2007: Sameer Stas; Adam Whaley-Connell; Javad Habibi; Lama Appesh; Melvin Hayden; Poorna R Karuparthi; Mahnaz Qazi; E Matthew Morris; Shawna A Cooper; C Daniel Link; Craig S Stump; Meredith Hay; Carlos M Ferrario; James R Sowers
Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling.
Endocrinology 2007;148(8):3773-80.
2007: Melvin Hayden; James R Sowers
Isletopathy in Type 2 diabetes mellitus: implications of islet RAS, islet fibrosis, islet amyloid, remodeling, and oxidative stress.
Antioxidants & redox signaling 2007;9(7):891-910.
2007: Melvin Hayden; James R Sowers
Redox imbalance in diabetes.
Antioxidants & redox signaling 2007;9(7):865-7.
2007: Adam Whaley-Connell; Gurushankar Govindarajan; Javad Habibi; Melvin Hayden; Shawna A Cooper; Yongzhong Wei; Lixin Ma; Mahnaz Qazi; Daniel Link; Poorna R Karuparthi; Craig S Stump; Carlos M Ferrario; James R Sowers
Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat.
American journal of physiology. Endocrinology and metabolism 2007;293(1):E355-63.
2007: Melvin Hayden; Poorna R Karuparthi; Camila Manrique; Guido Lastra; Javad Habibi; James R Sowers
Longitudinal ultrastructure study of islet amyloid in the HIP rat model of type 2 diabetes mellitus.
Experimental biology and medicine (Maywood, N.J.) 2007;232(6):772-9.
2007: Javad Habibi; Adam Whaley-Connell; Mahnaz Qazi; Melvin Hayden; Shawna A Cooper; Anthony Tramontano; John Thyfault; Craig S Stump; Carlos M Ferrario; Ranganath Muniyappa; James R Sowers
Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats.
Endocrinology 2007;148(5):2181-8.
2007: Preethi Yerram; Georges Saab; Poorna R Karuparthi; Melvin Hayden; Ramesh Khanna
Nephrogenic systemic fibrosis: a mysterious disease in patients with renal failure--role of gadolinium-based contrast media in causation and the beneficial effect of intravenous sodium thiosulfate.
Clinical journal of the American Society of Nephrology : CJASN 2007;2(2):258-63.
2007: Melvin Hayden; Nazif A Chowdhury; Shawna A Cooper; Adam Whaley-Connell; Javad Habibi; Lauren Witte; Charles E Wiedmeyer; Camila Manrique; Guido Lastra; Carlos M Ferrario; Craig S Stump; James R Sowers
Proximal tubule microvilli remodeling and albuminuria in the Ren2 transgenic rat.
American journal of physiology. Renal physiology 2007;292(2):F861-7.
2007: Kimberly S Delcour; Lokesh Tejwani; Melvin Hayden; Gurushankar Govindarajan
Intraventricular mechanical asynchrony in asymptomatic morbidly obese individuals.
Journal of the cardiometabolic syndrome 2007;2(4):305-8.
2007: Melvin Hayden; Poorna R Karuparthi; Javad Habibi; Chetan Wasekar; Guido Lastra; Camila Manrique; Sameer Stas; James R Sowers
Ultrastructural islet study of early fibrosis in the Ren2 rat model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell.
JOP : Journal of the pancreas 2007;8(6):725-38.
2007: Poorna R Karuparthi; Preethi Yerram; Diptesh Gupta; Melvin Hayden
High-cortisol states can masquerade as the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2007;2(3):223-6.
2007: Kurt M Sowers; Javad Habibi; Melvin Hayden
Diabetic nephropathy and tubulointerstitial fibrosis in cardiometabolic syndrome and type 2 diabetes mellitus.
Journal of the cardiometabolic syndrome 2007;2(2):143-8.
2007: Melvin Hayden
Islet amyloid and fibrosis in the cardiometabolic syndrome and type 2 diabetes mellitus.
Journal of the cardiometabolic syndrome 2007;2(1):70-5.
2007: Adam Whaley-Connell; E Matthew Morris; Nathan Rehmer; J Cipporah Yaghoubian; Yongzhong Wei; Melvin Hayden; Javad Habibi; Craig S Stump; James R Sowers
Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells.
American journal of nephrology 2007;27(1):15-23.
2006: Adam Whaley-Connell; Nazif A Chowdhury; Melvin Hayden; Craig S Stump; Javad Habibi; Charles E Wiedmeyer; Patricia E Gallagher; E Ann Tallant; Shawna A Cooper; C Daniel Link; Carlos M Ferrario; James R Sowers
Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat.
American journal of physiology. Renal physiology 2006;291(6):F1308-14.
2006: Melvin Hayden; Lisa Kolb; Nazif Chowdbury; Poorna R Karuparthi; Ramesh Khanna; James R Sowers
Detecting microalbuminuria and taking action in the cardiometabolic syndrome and type 2 diabetes mellitus.
Missouri medicine 2006;103(5):533-8.
2006: Melvin Hayden; Nazif A Chowdhury; Lauren Witte; James R Sowers
Microalbuminuria and proximal tubule remodeling in the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(2):107-14.
2006: Melvin Hayden
Atherogenic dyslipidemia.
Journal of the cardiometabolic syndrome 2006;1(3):166-7.
2006: Gurushankar Govindarajan; Melvin Hayden; Shawna A Cooper; Said Daibes Figueroa; Lixin Ma; Timothy Hoffman; Craig S Stump; James R Sowers
Metabolic derangements in the insulin-resistant heart.
Journal of the cardiometabolic syndrome 2006;1(2):102-6.
2006: Melvin Hayden; Poorna R Karuparthi; Nazif A Chowdhury; Gurushankar Govindarajan; Javad Habibi; Robert A Ortmann
Autoimmune vasculitis and plaque erosion in the cardiometabolic syndrome and type 2 diabetes mellitus.
Journal of the cardiometabolic syndrome 2006;1(3):228-32.
2006: Poorna R Karuparthi; Preethi Yerram; Melvin Hayden
Diastolic dysfunction in the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(5):369-72.
2006: Melvin Hayden; Nazif A Chowdhury; Gurushankar Govindarajan; Poorna R Karuparthi; Javad Habibi; James R Sowers
Myocardial myocyte remodeling and fibrosis in the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(5):326-33.
2006: Melvin Hayden; Craig S Stump; James R Sowers
Introduction: organ involvement in the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(1):16-24.
2006: Mohammad Bosem Abdeen; Nazif A Chowdhury; Melvin Hayden; Jamal A Ibdah
Nonalcoholic steatohepatitis and the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(1):36-40.
2006: Guido Lastra; Camila Manrique; Melvin Hayden
The role of beta-cell dysfunction in the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(1):41-6.
2006: Melvin Hayden; Lisa Kolb; Ramesh Khanna
Calciphylaxis and the cardiometabolic syndrome.
Journal of the cardiometabolic syndrome 2006;1(1):76-9.
2006: suresh shastry; Neetu Tyagi; Karni S Moshal; David Lominadze; Melvin Hayden; Suresh C Tyagi
GABA receptors ameliorate Hcy-mediated integrin shedding and constrictive collagen remodeling in microvascular endothelial cells.
Cell biochemistry and biophysics 2006;45(2):157-65.
2005: Alexander V Ovechkin; Neetu Tyagi; Walter E Rodriguez; Melvin Hayden; Karni S Moshal; Suresh C Tyagi
Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;99(6):2398-405.
2005: Melvin Hayden; Adam Whaley-Connell; James R Sowers
Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic nephropathy: paying homage to the podocyte.
American journal of nephrology 2005;25(6):553-69.
2005: Melvin Hayden; Suresh C Tyagi; Michelle M Kerklo; Mark R Nicolls
Type 2 diabetes mellitus as a conformational disease.
JOP : Journal of the pancreas 2005;6(4):287-302.
2005: Melvin Hayden; James R Sowers; Suresh C Tyagi
The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded.
Cardiovascular diabetology 2005;4(1):9.
2005: Melvin Hayden; Suresh C Tyagi; Lisa Kolb; James R Sowers; Ramesh Khanna
Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.
Cardiovascular diabetology 2005;4(1):4.
2005: Melvin Hayden; Suresh C Tyagi
Isolated low high density lipoprotein-cholesterol (HDL-C): implications of global risk reduction. Case report and systematic scientific review.
Cardiovascular diabetology 2005;4(1):1.
2004: suresh shastry; Neetu Tyagi; Melvin Hayden; Suresh C Tyagi
Proteomic analysis of homocysteine inhibition of microvascular endothelial cell angiogenesis.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(8):931-7.
2004: Melvin Hayden; Suresh C Tyagi
Neural redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and diabetic neuropathy.
Medical science monitor : international medical journal of experimental and clinical research 2004;10(12):RA291-307.
2004: Melvin Hayden
A primary care clinician's observations of the problem-based learning curriculum.
Missouri medicine 2004;101(6):541-3.
2004: Hanumanth K Reddy; Imam E Tjahja; Scott E Campbell; Joseph S Janicki; Melvin Hayden; Suresh C Tyagi
Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: a marker of cardiac dilatation.
Molecular and cellular biochemistry 2004;264(1-2):183-91.
2004: Teresa M Camp; Suresh C Tyagi; Giorgio M Aru; Melvin Hayden; Jawahar Mehta; Suresh C Tyagi
Doxycycline ameliorates ischemic and border-zone remodeling and endothelial dysfunction after myocardial infarction in rats.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(6):729-36.
2004: Melvin Hayden; Suresh C Tyagi
Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation.
Nutrition journal 2004;3():4.
2004: Melvin Hayden; Suresh C Tyagi
Vasa vasorum in plaque angiogenesis, metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: a malignant transformation.
Cardiovascular diabetology 2004;3():1.
2003: Teresa M Camp; Suresh C Tyagi; R M Senior; Melvin Hayden; S C Tyagi
Gelatinase B(MMP-9) an apoptotic factor in diabetic transgenic mice.
Diabetologia 2003;46(10):1438-45.
2003: Teresa M Camp; Lane M Smiley; Melvin Hayden; Suresh C Tyagi
Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats.
Journal of hypertension 2003;21(9):1719-27.
2003: Melvin Hayden; Suresh C Tyagi
Myocardial redox stress and remodeling in metabolic syndrome, type 2 diabetes mellitus, and congestive heart failure.
Medical science monitor : international medical journal of experimental and clinical research 2003;9(7):SR35-52.
2003: suresh shastry; Melvin Hayden; Pamela A Lucchesi; Suresh C Tyagi
Matrix metalloproteinase in left ventricular remodeling and heart failure.
Current cardiology reports 2003;5(3):200-4.
2003: Melvin Hayden; Suresh C Tyagi
Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress.
Cardiovascular diabetology 2003;2():2.
2003: Melvin Hayden
New use for folic acid.
Missouri medicine 2003;100(1):14-5.
2003: Suresh C Tyagi; Melvin Hayden
Role of nitric oxide in matrix remodeling in diabetes and heart failure.
Heart failure reviews 2003;8(1):23-8.
2002: Melvin Hayden
JNMA article helps doctors treat diabetic patients.
Journal of the National Medical Association 2002;94(12):1093.
2002: Melvin Hayden; Suresh C Tyagi
Intimal redox stress: accelerated atherosclerosis in metabolic syndrome and type 2 diabetes mellitus. Atheroscleropathy.
Cardiovascular diabetology 2002;1():3.
2002: Melvin Hayden
Pancreatic islet amyloid in type 2 diabetes mellitus: a clinical and historical review.
Missouri medicine 2002;99(9):495-8.
2002: Melvin Hayden
Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus.
JOP : Journal of the pancreas 2002;3(5):126-38.
2002: Matthew J Hunt; Giorgio M Aru; Melvin Hayden; Charles K Moore; Brian D Hoit; Suresh C Tyagi
Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L239-45.
2002: Melvin Hayden; Suresh C Tyagi
Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus.
JOP : Journal of the pancreas 2002;3(4):86-108.
2001: Melvin Hayden; S C Tyagi
"A" is for amylin and amyloid in type 2 diabetes mellitus.
JOP : Journal of the pancreas 2001;2(4):124-39.
2000: Vibhas S Mujumdar; Melvin Hayden; Suresh C Tyagi
Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells.
Journal of cellular physiology 2000;183(1):28-36.
2000: Melvin Hayden; S C Tyagi
Remodeling of the endocrine pancreas: the central role of amylin and insulin resistance.
Southern medical journal 2000;93(1):24-8.
1998: Melvin Hayden; S C Tyagi
Arterial vascular remodeling: the endothelial cell's central role.
Missouri medicine 1998;95(5):213-7.
1996: Suresh C Tyagi; S G Kumar; S J Haas; H K Reddy; D J Voelker; Melvin Hayden; Todd L Demmy; Richard A Schmaltz; J J Curtis
Post-transcriptional regulation of extracellular matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy.
Journal of molecular and cellular cardiology 1996;28(7):1415-28.