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Rasmus Clausen

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Joseph M Lipson; Bradley S Moore; Marie Thomsen; Rasmus P Clausen; James J La Clair; Michael D Burkart
A Tandem Chemoenzymatic Methylation by S-Adenosyl-L-methionine.
Stine B Vogensen; Petrine Wellendorph; H Steve White; Nrupa Borkar; Lars Jørgensen; Povl Krogsgaard-Larsen; Karsten K Madsen; Arne Schousboe; Jonas Skovgaard-Petersen; Rasmus P Clausen
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
Christina Mølck; Søren M Nielsen; Lars Ø Pedersen; Rasmus P Clausen; David E Gloriam; Kasper Harpsøe; Hermogenes N Jimenez; Ulf Madsen; Jesper M Mathiesen; Hans Bräuner-Osborne
Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.

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All Publications

2013: Joseph M Lipson; Bradley S Moore; Marie Thomsen; Rasmus P Clausen; James J La Clair; Michael D Burkart
A Tandem Chemoenzymatic Methylation by S-Adenosyl-L-methionine.
Chembiochem : a European journal of chemical biology 2013;14(8):950-3.
2013: Stine B Vogensen; Petrine Wellendorph; H Steve White; Nrupa Borkar; Lars Jørgensen; Povl Krogsgaard-Larsen; Karsten K Madsen; Arne Schousboe; Jonas Skovgaard-Petersen; Rasmus P Clausen
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
Journal of medicinal chemistry 2013;56(5):2160-4.
2012: Christina Mølck; Søren M Nielsen; Lars Ø Pedersen; Rasmus P Clausen; David E Gloriam; Kasper Harpsøe; Hermogenes N Jimenez; Ulf Madsen; Jesper M Mathiesen; Hans Bräuner-Osborne
Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators.
Molecular pharmacology 2012;82(5):929-37.
2012: Ulrike Leurs; Rasmus P Clausen; Jesper L Kristensen; Brian Lohse
Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).
Bioorganic & medicinal chemistry letters 2012;22(18):5811-3.
2012: Nathan Absalom; Tina Bay; Hans Bräuner-Osborne; Mary Chebib; Rasmus P Clausen; Laura F Eghorn; Bente Frølund; Nasiara Karim; Gitte M Knudsen; Jesper V Olsen; Inge S Villumsen; Petrine Wellendorph
α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).
Proceedings of the National Academy of Sciences of the United States of America 2012;109(33):13404-9.
2012: Birgitte H Kaae; Trine Kvist; Hans Bräuner-Osborne; Rasmus P Clausen; David Gloriam; Kasper Harpsøe; Hermogenes N Jimenez; Jesper M Mathiesen; Christina Mølck; Birgitte Nielsen; Søren M Nielsen; Per Sauerberg; Michelle A Uberti; Ulf Madsen
Structure-activity relationships for negative allosteric mGluR5 modulators.
ChemMedChem 2012;7(3):440-51.
2011: Brian Lohse; Anders L Nielsen; Lars Olsen; Rasmus P Clausen; Paul A C Cloos; Michael Gajhede; Charlotte Helgstrand; Jan B L Kristensen; Jesper L Kristensen
Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.
Angewandte Chemie (International ed. in English) 2011;50(39):9100-3.
2011: Karsten K Madsen; Arne Schousboe; Rasmus P Clausen; Bjarke Ebert; Povl Krogsgaard-Larsen; H Steve White
Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.
The Journal of pharmacology and experimental therapeutics 2011;338(1):214-9.
2011: Jan B L Kristensen; Jesper L Kristensen; Line H Kristensen; Anders L Nielsen; Lars Olsen; Charlotte Helgstrand; Lars Jørgensen; Lina Juknaite; Jette S Kastrup; Rasmus P Clausen; Michael Gajhede
Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: towards understanding selectivity of inhibitors targeting oncogenic histone demethylases.
FEBS letters 2011;585(12):1951-6.
2011: Brian Lohse; Karl Agger; Michael Gajhede; Kristian Helin; Jesper L Kristensen; Line H Kristensen; Rasmus P Clausen
Inhibitors of histone demethylases.
Bioorganic & medicinal chemistry 2011;19(12):3625-36.
2011: Stine Byskov Vogensen; Jeremy R Greenwood; Lennart Bunch; Rasmus P Clausen
Glutamate receptor agonists: stereochemical aspects.
Current topics in medicinal chemistry 2011;11(7):887-906.
2010: Jan Bornholdt; Jakob Felding; Rasmus P Clausen; Jesper L Kristensen
Ring opening of pymisyl-protected aziridines with organocuprates.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(41):12474-80.
2010: Petrine Wellendorph; Signe Høg; Paola Sabbatini; Martin H F Pedersen; Lars Martiny; Gitte M Knudsen; Bente Frølund; Rasmus P Clausen; Hans Bräuner-Osborne
Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites.
The Journal of pharmacology and experimental therapeutics 2010;335(2):458-64.
2010: Paola Sabbatini; Petrine Wellendorph; Signe Høg; Martin H F Pedersen; Hans Bräuner-Osborne; Lars Martiny; Bente Frølund; Rasmus P Clausen
Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites.
Journal of medicinal chemistry 2010;53(17):6506-10.
2009: Rasmus P Clausen; Peter Naur; Anders Skov Kristensen; Jeremy R Greenwood; Mette Strange; Hans Bräuner-Osborne; Anders A Jensen; Anne Sophie T Nielsen; Ulla Geneser; Lone M Ringgaard; Birgitte Nielsen; Darryl S Pickering; Lotte Brehm; Michael Gajhede; Povl Krogsgaard-Larsen; Jette S Kastrup
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.
Journal of medicinal chemistry 2009;52(15):4911-22.
2009: Karsten K Madsen; Rasmus P Clausen; Orla M Larsson; Povl Krogsgaard-Larsen; Arne Schousboe; H White
Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.
Journal of neurochemistry 2009;109 Suppl 1():139-44.
2009: Mangaleswaran Sivaprakasam; Kasper B Hansen; Olivier David; Birgitte Nielsen; Stephen F Traynelis; Rasmus P Clausen; François Couty; Lennart Bunch
Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors.
ChemMedChem 2009;4(1):110-7.
2008: Signe Høg; Petrine Wellendorph; Birgitte Nielsen; Karla Frydenvang; Ivar F Dahl; Hans Bräuner-Osborne; Lotte Brehm; Bente Frølund; Rasmus P Clausen
Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.
Journal of medicinal chemistry 2008;51(24):8088-95.
2008: Anders Bach; Celestine N Chi; Thomas B Olsen; Søren W Pedersen; Martin U Røder; Gar F Pang; Rasmus P Clausen; Per Jemth; Kristian Strømgaard
Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction.
Journal of medicinal chemistry 2008;51(20):6450-9.
2008: Rasmus P Clausen; Caspar Christensen; Kasper B Hansen; Jeremy R Greenwood; Lars Jørgensen; Nicola Micale; Jens Christian Madsen; Birgitte Nielsen; Jan Egebjerg; Hans Bräuner-Osborne; Stephen F Traynelis; Jesper L Kristensen
N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.
Journal of medicinal chemistry 2008;51(14):4179-87.
2008: Misty Smith; Gerald W Saunders; Rasmus P Clausen; Bente Frølund; Povl Krogsgaard-Larsen; Orla M Larsson; Arne Schousboe; Karen S Wilcox; H White
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC).
Epilepsy research 2008;79(1):6-13.
2007: Birgitte H Kaae; Kasper Harpsøe; Jette S Kastrup; Alberto Contreras Sanz; Darryl S Pickering; Bjørn Metzler; Rasmus P Clausen; Michael Gajhede; Per Sauerberg; Tommy Liljefors; Ulf Madsen
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.
Chemistry & biology 2007;14(11):1294-303.
2007: Kevin Erreger; Matthew T Geballe; Anders Skov Kristensen; Philip E Chen; Kasper B Hansen; C Justin Lee; Hongjie Yuan; Phuong Le; Polina Lyuboslavsky; Nicola Micale; Lars Jørgensen; Rasmus P Clausen; David J A Wyllie; James P Snyder; Stephen F Traynelis
Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors.
Molecular pharmacology 2007;72(4):907-20.
2007: Anders A Jensen; Thomas Christesen; Ulrik Bølcho; Jeremy R Greenwood; Giovanna Postorino; Stine B Vogensen; Tommy N Johansen; Jan Egebjerg; Hans Bräuner-Osborne; Rasmus P Clausen
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
Journal of medicinal chemistry 2007;50(17):4177-85.
2007: Stine B Vogensen; Karla Frydenvang; Jeremy R Greenwood; Giovanna Postorino; Birgitte Nielsen; Darryl S Pickering; Bjarke Ebert; Ulrik Bølcho; Jan Egebjerg; Michael Gajhede; Jette S Kastrup; Tommy N Johansen; Rasmus P Clausen; Povl Krogsgaard-Larsen
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
Journal of medicinal chemistry 2007;50(10):2408-14.
2007: Charlotte G Jørgensen; Hans Bräuner-Osborne; Birgitte Nielsen; Jan Kehler; Rasmus P Clausen; Povl Krogsgaard-Larsen; Ulf Madsen
Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.
Bioorganic & medicinal chemistry 2007;15(10):3524-38.
2007: Charlotte G Jørgensen; Rasmus P Clausen; Kasper B Hansen; Hans Bräuner-Osborne; Birgitte Nielsen; Bjørn Metzler; Birgitte Bjørn Metzler; Jan Kehler; Povl Krogsgaard-Larsen; Ulf Madsen
Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.
Organic & biomolecular chemistry 2007;5(3):463-71.
2006: Christian A Olsen; Caspar Christensen; Birgitte Nielsen; Mohamed M Farah; Farah M Mohamed; Matthias Witt; Rasmus P Clausen; Jesper L Kristensen; Henrik Franzyk; Jerzy W Jaroszewski
Aminolysis of resin-bound N-nosylaziridine-2-carboxylic acids.
Organic letters 2006;8(15):3371-4.
2006: Rasmus P Clausen
Organic chemistry at the interface to biology.
Chembiochem : a European journal of chemical biology 2006;7(5):845-9.
2006: Rasmus P Clausen; Bente Frølund; Orla M Larsson; Arne Schousboe; Povl Krogsgaard-Larsen; H White
A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.
Neurochemistry international 2006;48(6-7):637-42.
2006: Rasmus P Clausen; Karsten Madsen; Orla M Larsson; Bente Frølund; Povl Krogsgaard-Larsen; Arne Schousboe
Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.
Advances in pharmacology (San Diego, Calif.) 2006;54():265-84.
2006: Signe Høg; Jeremy R Greenwood; Karsten B Madsen; Orla M Larsson; Bente Frølund; Arne Schousboe; Povl Krogsgaard-Larsen; Rasmus P Clausen
Structure-activity relationships of selective GABA uptake inhibitors.
Current topics in medicinal chemistry 2006;6(17):1861-82.
2005: Kasper B Hansen; Rasmus P Clausen; Esben J Bjerrum; Christian Bechmann; Jeremy R Greenwood; Caspar Christensen; Jesper L Kristensen; Jan Egebjerg; Hans Bräuner-Osborne
Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis.
Molecular pharmacology 2005;68(6):1510-23.
2005: Petrine Wellendorph; Signe Høg; Jeremy R Greenwood; Anne de Lichtenberg; Birgitte Nielsen; Bente Frølund; Lotte Brehm; Rasmus P Clausen; Hans Bräuner-Osborne
Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.
The Journal of pharmacology and experimental therapeutics 2005;315(1):346-51.
2005: Stine B Vogensen; Rasmus P Clausen; Jeremy R Greenwood; Tommy N Johansen; Darryl S Pickering; Birgitte Nielsen; Bjarke Ebert; Povl Krogsgaard-Larsen
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.
Journal of medicinal chemistry 2005;48(9):3438-42.
2005: Rasmus P Clausen; Ejner K Moltzen; Jens Perregaard; Sibylle M Lenz; Connie Sanchez; Erik Falch; Bente Frølund; Tina Bolvig; Alan Sarup; Orla M Larsson; Arne Schousboe; Povl Krogsgaard-Larsen
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.
Bioorganic & medicinal chemistry 2005;13(3):895-908.
2005: H White; William P Watson; Suzanne L Hansen; Scott Slough; Jens Perregaard; Alan Sarup; Tina Bolvig; Gitte Petersen; Orla M Larsson; Rasmus P Clausen; Bente Frølund; Erik Falch; Povl Krogsgaard-Larsen; Arne Schousboe
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
The Journal of pharmacology and experimental therapeutics 2005;312(2):866-74.
2004: Rasmus P Clausen; Kasper B Hansen; Patrizia Calí; Birgitte Nielsen; Jeremy R Greenwood; Mikael Begtrup; Jan Egebjerg; Hans Bräuner-Osborne
The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.
European journal of pharmacology 2004;499(1-2):35-44.
2004: Stine B Vogensen; Jeremy R Greenwood; Annemarie R Varming; Lotte Brehm; Darryl S Pickering; Birgitte Nielsen; Tommy Liljefors; Rasmus P Clausen; Tommy N Johansen; Povl Krogsgaard-Larsen
A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.
Organic & biomolecular chemistry 2004;2(2):206-13.
2002: Rasmus P Clausen; Hans Bräuner-Osborne; Jeremy R Greenwood; Mette Brunsgaard Hermit; Tine B Stensbøl; Birgitte Nielsen; Povl Krogsgaard-Larsen
Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.
Journal of medicinal chemistry 2002;45(19):4240-5.