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Hugues BEDOUELLE

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Nora Zidane; Laetitia Bremand; Philippe Dussart; Maria Elena Villani; Hugues BEDOUELLE
Thermodynamic stability of domain III from the envelope protein of flaviviruses and its improvement by molecular design.
Nicolas Hegerle; Lamya Rayat; Nora Zidane; Hugues BEDOUELLE; Grégory Dore; Nicole Guiso
In-vitro and in-vivo analysis of the production of the Bordetella type three secretion system effector A in Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Nora Zidane; Mohamed B Ould-Abeih; Isabelle Petit-Topin; Hugues BEDOUELLE
The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors.

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2013: Nora Zidane; Laetitia Bremand; Philippe Dussart; Maria Elena Villani; Hugues BEDOUELLE
Thermodynamic stability of domain III from the envelope protein of flaviviruses and its improvement by molecular design.
Protein engineering, design & selection : PEDS 2013;26(6):389-99.
2013: Nicolas Hegerle; Lamya Rayat; Nora Zidane; Hugues BEDOUELLE; Grégory Dore; Nicole Guiso
In-vitro and in-vivo analysis of the production of the Bordetella type three secretion system effector A in Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Microbes and infection / Institut Pasteur 2013;15(5):399-408.
2013: Nora Zidane; Mohamed B Ould-Abeih; Isabelle Petit-Topin; Hugues BEDOUELLE
The folded and disordered domains of human ribosomal protein SA have both idiosyncratic and shared functions as membrane receptors.
Bioscience reports 2013;33(1):113-24.
2012: Mohamed B Ould-Abeih; Isabelle Petit-Topin; Nora Zidane; Bruno Baron; Hugues BEDOUELLE
Multiple folding states and disorder of ribosomal protein SA, a membrane receptor for laminin, anticarcinogens, and pathogens.
Biochemistry 2012;51(24):4807-21.
2012: Joseph J B Cockburn; Lark L Coffey; Nickolas Fretes; Carlos M Kikuti; M Erika Navarro Sanchez; Fernando Arenzana Seisdedos; Hugues BEDOUELLE; Isabelle Staropoli; Agathe Urvoas; Felix A Rey
Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.
Structure (London, England : 1993) 2012;20(2):303-14.
2011: Frederico F Miranda; Elodie Brient-Litzler; Nora Zidane; Frédéric Pecorari; Hugues BEDOUELLE
Reagentless fluorescent biosensors from artificial families of antigen binding proteins.
Biosensors & bioelectronics 2011;26(10):4184-90.
2010: Samantha Brandler; Claude Ruffie; Valérie Najburg; Marie-Pascale Frenkiel; Hugues BEDOUELLE; Philippe Desprès; Frédéric Tangy
Pediatric measles vaccine expressing a dengue tetravalent antigen elicits neutralizing antibodies against all four dengue viruses.
Vaccine 2010;28(41):6730-9.
2010: Elodie Brient-Litzler; Andreas Plückthun; Hugues BEDOUELLE
Knowledge-based design of reagentless fluorescent biosensors from a designed ankyrin repeat protein.
Protein engineering, design & selection : PEDS 2010;23(4):229-41.
2009: Rajiv G Tawar; Stéphane Duquerroy; Clemens Vonrhein; Paloma F Varela; Laurence Damier-Piolle; Nathalie Castagné; Kirsty MacLellan; Hugues BEDOUELLE; Gérard Bricogne; David Bhella; Jean-François Eléouët; Félix A Rey
Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus.
Science (New York, N.Y.) 2009;326(5957):1279-83.
2009: Oren Hershkovitz; Benyamin Rosental; Lior Ann Rosenberg; Martha Erika Navarro-Sanchez; Sergey Jivov; Alon Zilka; Orly Gershoni-Yahalom; Elodie Brient-Litzler; Hugues BEDOUELLE; Joanna W Ho; Kerry S Campbell; Bracha Rager-Zisman; Philippe Despres; Angel Porgador
NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2610-21.
2008: Thibaut Pelat; Hugues BEDOUELLE; Anthony R Rees; Susan J Crennell; Marie-Paule Lefranc; Philippe Thullier
Germline humanization of a non-human primate antibody that neutralizes the anthrax toxin, by in vitro and in silico engineering.
Journal of molecular biology 2008;384(5):1400-7.
2008: Emmanuelle Laffly; Thibaut Pelat; Frédéric Cédrone; Stéphane Blésa; Hugues BEDOUELLE; Philippe Thullier
Improvement of an antibody neutralizing the anthrax toxin by simultaneous mutagenesis of its six hypervariable loops.
Journal of molecular biology 2008;378(5):1094-103.
2007: Olesia Lisova; Florence Hardy; Vincent Petit; Hugues BEDOUELLE
Mapping to completeness and transplantation of a group-specific, discontinuous, neutralizing epitope in the envelope protein of dengue virus.
The Journal of general virology 2007;88(Pt 9):2387-97.
2007: Samantha Brandler; Marianne Lucas-Hourani; Arnaud Moris; Marie-Pascale Frenkiel; Chantal Combredet; Michèle Février; Hugues BEDOUELLE; Olivier Schwartz; Philippe Desprès; Frédéric Tangy
Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virus.
PLoS neglected tropical diseases 2007;1(3):e96.
2006: Elodie Monsellier; Hugues BEDOUELLE
Improving the stability of an antibody variable fragment by a combination of knowledge-based approaches: validation and mechanisms.
Journal of molecular biology 2006;362(3):580-93.
2006: Hugues BEDOUELLE; Laurent Belkadi; Patrick England; J Iñaki Guijarro; Olesia Lisova; Agathe Urvoas; Muriel DELEPIERRE; Philippe Thullier
Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus.
The FEBS journal 2006;273(1):34-46.
2005: Elodie Monsellier; Hugues BEDOUELLE
Quantitative measurement of protein stability from unfolding equilibria monitored with the fluorescence maximum wavelength.
Protein engineering, design & selection : PEDS 2005;18(9):445-56.
2004: Martial Renard; Hugues BEDOUELLE
Improving the sensitivity and dynamic range of reagentless fluorescent immunosensors by knowledge-based design.
Biochemistry 2004;43(49):15453-62.
2003: Martial Renard; Laurent Belkadi; Hugues BEDOUELLE
Deriving topological constraints from functional data for the design of reagentless fluorescent immunosensors.
Journal of molecular biology 2003;326(1):167-75.
2002: Hugues BEDOUELLE; Martial Renard; Laurent Belkadi; Patrick England
Harnessing malE for the study of antigen/antibody recognitions.
Research in microbiology 2002;153(7):395-8.
2002: Martial Renard; Laurent Belkadi; Nicolas Hugo; Patrick England; Danièle Altschuh; Hugues BEDOUELLE
Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies.
Journal of molecular biology 2002;318(2):429-42.
2002: J Iñaki Guijarro; Alessandro Pintar; Ada Prochnicka-Chalufour; Valérie Guez; Bernard Gilquin; Hugues BEDOUELLE; Muriel DELEPIERRE
Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase.
Structure (London, England : 1993) 2002;10(3):311-7.
2001: Philippe Thullier; Caroline Demangel; Hugues BEDOUELLE; Françoise Mégret; A Jouan; Vincent Deubel; JC Mazié; Pierre Lafaye
Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism.
The Journal of general virology 2001;82(Pt 8):1885-92.
2001: C Gaillard; Hugues BEDOUELLE
An essential residue in the flexible peptide linking the two idiosynchratic domains of bacterial tyrosyl-tRNA synthetases.
Biochemistry 2001;40(24):7192-9.
2000: P Rondard; Hugues BEDOUELLE
Mutational scanning of a hairpin loop in the tryptophan synthase beta-subunit implicated in allostery and substrate channeling.
Biological chemistry 2000;381(12):1185-93.
2000: Valérie Guez; S Nair; Alain Chaffotte; Hugues BEDOUELLE
The anticodon-binding domain of tyrosyl-tRNA synthetase: state of folding and origin of the crystallographic disorder.
Biochemistry 2000;39(7):1739-47.
1999: Alessandro Pintar; Valérie Guez; C Castagné; Hugues BEDOUELLE; Muriel DELEPIERRE
Secondary structure of the C-terminal domain of the tyrosyl-transfer RNA synthetase from Bacillus stearothermophilus: a novel type of anticodon binding domain?
FEBS letters 1999;446(1):81-5.
1999: Lutz Jermutus; Valérie Guez; Hugues BEDOUELLE
Disordered C-terminal domain of tyrosyl-tRNA synthetase: secondary structure prediction.
Biochimie 1999;81(3):235-44.
1999: Y C Park; Valérie Guez; Hugues BEDOUELLE
Experimental evolution of a dense cluster of residues in tyrosyl-tRNA synthetase: quantitative effects on activity, stability and dimerization.
Journal of molecular biology 1999;286(2):563-77.
1999: Patrick England; R Nageotte; Martial Renard; Anne-Laure Page; Hugues BEDOUELLE
Functional characterization of the somatic hypermutation process leading to antibody D1.3, a high affinity antibody directed against lysozyme.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2129-36.
1998: P Rondard; Hugues BEDOUELLE
A mutational approach shows similar mechanisms of recognition for the isolated and integrated versions of a protein epitope.
The Journal of biological chemistry 1998;273(52):34753-9.
1998: Pierre Guermonprez; Patrick England; Hugues BEDOUELLE; CLAUDE LECLERC
The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4542-8.
1998: Y C Park; Hugues BEDOUELLE
Dimeric tyrosyl-tRNA synthetase from Bacillus stearothermophilus unfolds through a monomeric intermediate. A quantitative analysis under equilibrium conditions.
The Journal of biological chemistry 1998;273(29):18052-9.
1997: P Rondard; Michel E Goldberg; Hugues BEDOUELLE
Mutational analysis of an antigenic peptide shows recognition in a loop conformation.
Biochemistry 1997;36(29):8962-8.
1997: P Rondard; F Brégégère; Anne Lecroisey; Muriel DELEPIERRE; Hugues BEDOUELLE
Conformational and functional properties of an undecapeptide epitope fused with the C-terminal end of the maltose binding protein.
Biochemistry 1997;36(29):8954-61.
1997: F Brégégère; Patrick England; Lisa Djavadi-Ohaniance; Hugues BEDOUELLE
Recognition of E. coli tryptophan synthase by single-chain Fv fragments: comparison of PCR-cloning variants with the parental antibodies.
Journal of molecular recognition : JMR 1997;10(4):169-81.
1997: Patrick England; F Brégégère; Hugues BEDOUELLE
Energetic and kinetic contributions of contact residues of antibody D1.3 in the interaction with lysozyme.
Biochemistry 1997;36(1):164-72.
1996: A Blondel; R Nageotte; Hugues BEDOUELLE
Destabilizing interactions between the partners of a bifunctional fusion protein.
Protein engineering 1996;9(2):231-8.
1996: V Guez-Ivanier; Hugues BEDOUELLE
Disordered C-terminal domain of tyrosyl transfer-RNA synthetase: evidence for a folded state.
Journal of molecular biology 1996;255(1):110-20.
1995: Hugues BEDOUELLE; R Nageotte
Macromolecular recognition through electrostatic repulsion.
The EMBO journal 1995;14(12):2945-50.
1994: F Brégégère; J Schwartz; Hugues BEDOUELLE
Bifunctional hybrids between the variable domains of an immunoglobulin and the maltose-binding protein of Escherichia coli: production, purification and antigen binding.
Protein engineering 1994;7(2):271-80.
1993: V Guez-Ivanier; M Hermann; D Baldwin; Hugues BEDOUELLE
Mapping the stability determinants of bacterial tyrosyl transfer RNA synthetases by an experimental evolutionary approach.
Journal of molecular biology 1993;234(1):209-21.
1993: Hugues BEDOUELLE
Symmetrical interactions between the translational operator of the thrS gene and dimeric threonyl transfer RNA synthetase.
Journal of molecular biology 1993;230(3):704-8.
1993: Hugues BEDOUELLE; V Guez-Ivanier; R Nageotte
Discrimination between transfer-RNAs by tyrosyl-tRNA synthetase.
Biochimie 1993;75(12):1099-108.
1992: A Vidal-Cros; Hugues BEDOUELLE
Role of residue Glu152 in the discrimination between transfer RNAs by tyrosyl-tRNA synthetase from Bacillus stearothermophilus.
Journal of molecular biology 1992;223(3):801-10.
1992: F Brégégère; Hugues BEDOUELLE
[Expression, isolation and purification of antibody fragments fused to maltose-binding protein in Escherichia coli].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1992;314(12):527-32.
1991: A Blondel; Hugues BEDOUELLE
Engineering the quaternary structure of an exported protein with a leucine zipper.
Protein engineering 1991;4(4):457-61.
1990: A Blondel; Hugues BEDOUELLE
Export and purification of a cytoplasmic dimeric protein by fusion to the maltose-binding protein of Escherichia coli.
European journal of biochemistry / FEBS 1990;193(2):325-30.
1990: Hugues BEDOUELLE
Recognition of tRNA(Tyr) by tyrosyl-tRNA synthetase.
Biochimie 1990;72(8):589-98.
1990: Hugues BEDOUELLE; Valérie Guez; A Vidal-Cros; M Hermann
Overproduction of tyrosyl-tRNA synthetase is toxic to Escherichia coli: a genetic analysis.
Journal of bacteriology 1990;172(7):3940-5.
1990: M Hermann; Hugues BEDOUELLE
A method for monitoring double restriction cuts within a polylinker.
Research in microbiology 1990;141(2):187-9.
1989: E Labouze; Hugues BEDOUELLE
Structural and kinetic bases for the recognition of tRNATyr by tyrosyl-tRNA synthetase.
Journal of molecular biology 1989;205(4):729-35.
1988: Alan Fersht; J W Knill-Jones; Hugues BEDOUELLE; G Winter
Reconstruction by site-directed mutagenesis of the transition state for the activation of tyrosine by the tyrosyl-tRNA synthetase: a mobile loop envelopes the transition state in an induced-fit mechanism.
Biochemistry 1988;27(5):1581-7.
1988: Hugues BEDOUELLE; P Duplay
Production in Escherichia coli and one-step purification of bifunctional hybrid proteins which bind maltose. Export of the Klenow polymerase into the periplasmic space.
European journal of biochemistry / FEBS 1988;171(3):541-9.
1987: P Duplay; S Szmelcman; Hugues BEDOUELLE; Maurice Hofnung
Silent and functional changes in the periplasmic maltose-binding protein of Escherichia coli K12. I. Transport of maltose.
Journal of molecular biology 1987;194(4):663-73.
1987: Hugues BEDOUELLE; P Duplay; Maurice Hofnung
[Expression, export and one-step purification of proteins by fusion to the MalE protein of E. coli].
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1987;305(17):623-6.
1986: Hugues BEDOUELLE; G Winter
A model of synthetase/transfer RNA interaction as deduced by protein engineering.
Nature 1986;320(6060):371-3.
1986: P Carter; Hugues BEDOUELLE; G Winter
Construction of heterodimer tyrosyl-tRNA synthetase shows tRNATyr interacts with both subunits.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(5):1189-92.
1985: Hugues BEDOUELLE; P Carter; Mary Waye; G Winter; D M Lowe; A J Wilkinson; Alan Fersht
Engineering of tyrosyl tRNA synthetase.
Biochimie 1985;67(7-8):737-43.
1985: P Duplay; Hugues BEDOUELLE; S Szmelcman; Maurice Hofnung
Linker mutagenesis in the gene encoding the periplasmic maltose-binding protein of E. coli.
Biochimie 1985;67(7-8):849-51.
1985: P Carter; Hugues BEDOUELLE; G Winter
Improved oligonucleotide site-directed mutagenesis using M13 vectors.
Nucleic acids research 1985;13(12):4431-43.
1984: P Duplay; Hugues BEDOUELLE; A Fowler; I Zabin; William Saurin; Maurice Hofnung
Sequences of the malE gene and of its product, the maltose-binding protein of Escherichia coli K12.
The Journal of biological chemistry 1984;259(16):10606-13.
1983: Hugues BEDOUELLE
Mutations in the promoter regions of the malEFG and malK-lamB operons of Escherichia coli K12.
Journal of molecular biology 1983;170(4):861-82.
1982: Hugues BEDOUELLE; U Schmeissner; M Hofnung; M Rosenberg
Promoters of the malEFG and malK-lamB operons in Escherichia coli K12.
Journal of molecular biology 1982;161(4):519-31.
1982: Hugues BEDOUELLE
Structure of the malB regulatory interval.
Annales de microbiologie 1982;133A(1):65-70.
1982: Hugues BEDOUELLE; M Hofnung
A DNA sequence containing the control regions of the malEFG and malK-lamB operons in Escherichia coli K12.
Molecular & general genetics : MGG 1982;185(1):82-7.
1981: Hugues BEDOUELLE; M Hofnung
Functional implications of secondary structure analysis of wild type and mutant bacterial signal peptides.
Progress in clinical and biological research 1981;63():399-403.
1980: Hugues BEDOUELLE; P J Bassford; A V Fowler; I Zabin; Jonathan R. Beckwith; Maurice Hofnung
Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli.
Nature 1980;285(5760):78-81.
1980: M Hermann; O Chaudé; N Weill; Hugues BEDOUELLE; M Hofnung
Adaptation of the salmonella/mammalian microsome test to the determination of the mutagenic properties of mineral oils.
Mutation research 1980;77(4):327-39.
1978: Hugues BEDOUELLE; M Hofnung
[Short term tests of carcinogenesis. Evaluation, predictive values, and diverse strategies].
Comptes rendus hebdomadaires des séances de l'Académie des sciences. Série D: Sciences naturelles 1978;287(9):891-4.