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WENZHEN DUAN

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Jing Jin; Mark P Mattson; Qi Peng; William Wood; Yongqing Zhang; Kevin G Becker; Yong Cheng; Emmette Hutchison; WENZHEN DUAN
Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin.
Zhihong Guo; Russell L Margolis; Brent A Orr; Olga Pletnikova; Adam Rosenblatt; Christopher A Ross; Gay Rudow; Kari-Elise Codispoti; Barbara J Crain; WENZHEN DUAN; Juan C Troncoso
Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease.
Jinrong Fu; Serena A Hageman; Katelyn Hotaling; Mali Jiang; Jing Jin; Qi Peng; Christopher A Ross; Lan Xiang; nicolas arbez; Robert H Cichewicz; Trevor K Ellis; WENZHEN DUAN
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.

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2012: Jing Jin; Mark P Mattson; Qi Peng; William Wood; Yongqing Zhang; Kevin G Becker; Yong Cheng; Emmette Hutchison; WENZHEN DUAN
Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin.
Journal of neurochemistry 2012;123(4):477-90.
2012: Zhihong Guo; Russell L Margolis; Brent A Orr; Olga Pletnikova; Adam Rosenblatt; Christopher A Ross; Gay Rudow; Kari-Elise Codispoti; Barbara J Crain; WENZHEN DUAN; Juan C Troncoso
Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 2012;27(11):1379-86.
2012: Jinrong Fu; Serena A Hageman; Katelyn Hotaling; Mali Jiang; Jing Jin; Qi Peng; Christopher A Ross; Lan Xiang; nicolas arbez; Robert H Cichewicz; Trevor K Ellis; WENZHEN DUAN
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
The Journal of biological chemistry 2012;287(29):24460-72.
2012: Manisha Aggarwal; WENZHEN DUAN; Zhipeng Hou; Michael I Miller; Susumu Mori; Qi Peng; Neal Rakesh; Christopher A Ross; Jiangyang Zhang
Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging.
NeuroImage 2012;60(4):2086-95.
2012: Elaine Waldron-Roby; XiaoFang Wang; Erin Watkin; Deborah Swing; Lino Tessarollo; nicolas arbez; WENZHEN DUAN; Graham Kyrenia Rona; Michael R Hayden; Zhipeng Hou; Mali Jiang; Susumu Mori; Mikhail V Pletnikov; TAMARA RATOVITSKI; Christopher A Ross
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(1):183-93.
2012: Mali Jiang; Huan Cai; Ruth Luthi-Carter; Kellie L K Tamashiro; Jiangyang Zhang; Lin Du; Bronwen Martin; Susan Aja; Susumu Mori; Christopher A Ross; Timothy H Moran; Stuart Maudsley; Lan Xiang; David M Holtzman; Mark P Mattson; Jiawei Wang; Qi Peng; Tamara Seredenina; Katherine Sommers; Hyunkyung Jeong; Zhipeng Hou; X William Yang; nicolas arbez; Jennifer Qian; Tim West; Dimitri Krainc; Jinrong Fu; Robert H Cichewicz; Shanshan Zhu; WENZHEN DUAN
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Nature medicine 2012;18(1):153-8.
2011: Zhongmin Xiang; Jiangyang Zhang; Elisa Brilli; Elena Cattaneo; Libin Cui; WENZHEN DUAN; Hyun-Kyung Jeong; Valerio Leoni; Qi Peng; Steven A Reeves; Marta Valenza; Dimitri Krainc
Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(26):9544-53.
2011: Yong Cheng; Qi Peng; Zhipeng Hou; Manisha Aggarwal; Jiangyang Zhang; Susumu Mori; Christopher A Ross; WENZHEN DUAN
Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model.
NeuroImage 2011;56(3):1027-34.
2010: WENZHEN DUAN; Christopher A Ross
Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction.
Current drug targets 2010;11(10):1281-92.
2010: Mali Jiang; Yair Porat-Shliom; Zhong Pei; Yong Cheng; Lan Xiang; Katherine Sommers; Qing Li; Frank Gillardon; Bastian Hengerer; CYNTHIA BERLINICKE; Wanli Smith; Donald J Zack; Michelle A Poirier; Christopher A Ross; WENZHEN DUAN
Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.
Journal of neurochemistry 2010;114(2):419-29.
2010: Jiangyang Zhang; Qi Peng; Q Li; Neda Jahanshad; Zhipeng Hou; Mali Jiang; Naoki Masuda; Douglas R Langbehn; Michael I Miller; Susumu Mori; Christopher A Ross; WENZHEN DUAN
Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images.
NeuroImage 2010;49(3):2340-51.
2008: WENZHEN DUAN; Qi Peng; Naoki Masuda; ERIC FORD; ERIK TRYGGESTAD; Bruce Ladenheim; Ming Zhao; Jean Lud Cadet; John Wong; Christopher A Ross
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease.
Neurobiology of disease 2008;30(3):312-22.
2008: Naoki Masuda; Qi Peng; Qing Li; Mali Jiang; Yideng Liang; Xiaofang Wang; Ming Zhao; Wenfei Wang; Christopher A Ross; WENZHEN DUAN
Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.
Neurobiology of disease 2008;30(3):293-302.
2008: Marcus Kostka; Tobias Högen; Karin M Danzer; Johannes Levin; Matthias Habeck; Andreas Wirth; Richard Wagner; Charles G Glabe; Sabine Finger; Udo Heinzelmann; Patrick Garidel; WENZHEN DUAN; Christopher A Ross; Hans A Kretzschmar; Armin Giese
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
The Journal of biological chemistry 2008;283(16):10992-1003.
2008: Qi Peng; Naoki Masuda; Mali Jiang; Qing Li; Ming Zhao; Christopher A Ross; WENZHEN DUAN
The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.
Experimental neurology 2008;210(1):154-63.
2008: Zhihong Guo; Haiyang Jiang; Xiangru Xu; WENZHEN DUAN; Mark P Mattson
Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.
The Journal of biological chemistry 2008;283(3):1754-63.
2007: Russell B Williams; Will R Gutekunst; P Matthew Joyner; WENZHEN DUAN; Qing Li; Christopher A Ross; Todd D Williams; Robert H Cichewicz
Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity.
Journal of agricultural and food chemistry 2007;55(23):9450-6.
2007: Benjamin Sredni; Revital Geffen-Aricha; WENZHEN DUAN; Michael Albeck; Frances Shalit; Harry M Lander; Noa Kinor; Ortal Sagi; Amnon Albeck; Sigal Yosef; Miri Brodsky; Dvora Sredni-Kenigsbuch; Tali Sonino; Dan Longo; Mark P Mattson; Gal Yadid
Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(8):1870-83.
2007: Xiangru Xu; Ming Zhan; WENZHEN DUAN; Vinayakumar Prabhu; Randall Brenneman; William Wood; Jeff Firman; Huai Li; Peisu Zhang; Carol Ibe; Alan B Zonderman; Dan Longo; Suresh Poosala; Kevin G Becker; Mark P Mattson
Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender.
Genome biology 2007;8(11):R234.
2005: Wenfei Wang; WENZHEN DUAN; Shuichi Igarashi; Hokuto Morita; Masayuki Nakamura; Christopher A Ross
Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model.
Neurobiology of disease 2005;20(2):500-8.
2004: WENZHEN DUAN; Zhihong Guo; Haiyang Jiang; Bruce Ladenheim; Xiangru Xu; Jean Lud Cadet; Mark P Mattson
Paroxetine retards disease onset and progression in Huntingtin mutant mice.
Annals of neurology 2004;55(4):590-4.
2004: Mark P Mattson; WENZHEN DUAN; Ruiqian Wan; Zhihong Guo
Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2004;1(1):111-6.
2003: WENZHEN DUAN; Zhihong Guo; Haiyang Jiang; Melvin Ware; Mark P Mattson
Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor.
Endocrinology 2003;144(6):2446-53.
2003: WENZHEN DUAN; Zhihong Guo; Haiyang Jiang; Melvin Ware; Xiao-Jiang Li; Mark P Mattson
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2911-6.
2003: Mark P Mattson; WENZHEN DUAN; Zhihong Guo
Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms.
Journal of neurochemistry 2003;84(3):417-31.
2002: WENZHEN DUAN; Xiaoxiang Zhu; Bruce Ladenheim; Qian-Sheng Yu; Zhihong Guo; Jonathan M Oyler; Roy G Cutler; Jean Lud Cadet; Nigel H Greig; Mark P Mattson
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.
Annals of neurology 2002;52(5):597-606.
2002: Mark P Mattson; WENZHEN DUAN; Sic L Chan; Aiwu Cheng; Norman Haughey; Devin S Gary; Zhihong Guo; Jaewon Lee; Katsutoshi Furukawa
Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior.
Neurobiology of aging 2002;23(5):695-705.
2002: Jaewon Lee; WENZHEN DUAN; Mark P Mattson
Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice.
Journal of neurochemistry 2002;82(6):1367-75.
2002: Mark P Mattson; Sic L Chan; WENZHEN DUAN
Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior.
Physiological reviews 2002;82(3):637-72.
2002: Mark P Mattson; WENZHEN DUAN; Navin Maswood
How does the brain control lifespan?
Ageing research reviews 2002;1(2):155-65.
2002: Mark P Mattson; Inna I Kruman; WENZHEN DUAN
Folic acid and homocysteine in age-related disease.
Ageing research reviews 2002;1(1):95-111.
2002: WENZHEN DUAN; Bruce Ladenheim; Roy G Cutler; Inna I Kruman; Jean Lud Cadet; Mark P Mattson
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease.
Journal of neurochemistry 2002;80(1):101-10.
2001: Mark P Mattson; WENZHEN DUAN; J Lee; Z Guo
Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms.
Mechanisms of ageing and development 2001;122(7):757-78.
2001: WENZHEN DUAN; Jaewon Lee; Zhihong Guo; Mark P Mattson
Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury.
Journal of molecular neuroscience : MN 2001;16(1):1-12.
2001: Mark P Mattson; WENZHEN DUAN; Ward Anthony Pedersen; Carsten Culmsee
Neurodegenerative disorders and ischemic brain diseases.
Apoptosis : an international journal on programmed cell death 2001;6(1-2):69-81.
2001: Mark P Mattson; Devin S Gary; Sic L Chan; WENZHEN DUAN
Perturbed endoplasmic reticulum function, synaptic apoptosis and the pathogenesis of Alzheimer's disease.
Biochemical Society symposium 2001;(67):151-62.
2001: WENZHEN DUAN; Zhihong Guo; Mark P Mattson
Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice.
Journal of neurochemistry 2001;76(2):619-26.
2000: Jaewon Lee; WENZHEN DUAN; Jeffrey M Long; Donald Ingram; Mark P Mattson
Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats.
Journal of molecular neuroscience : MN 2000;15(2):99-108.
2000: WENZHEN DUAN; Z Guo; Mark P Mattson
Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid.
Experimental neurology 2000;165(1):1-11.
1999: WENZHEN DUAN; Zhiming Zhang; Don M Gash; Mark P Mattson
Participation of prostate apoptosis response-4 in degeneration of dopaminergic neurons in models of Parkinson's disease.
Annals of neurology 1999;46(4):587-97.
1999: Mark P Mattson; WENZHEN DUAN
"Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders.
Journal of neuroscience research 1999;58(1):152-66.
1999: Mark P Mattson; WENZHEN DUAN; Sic L Chan; Simonetta Camandola
Par-4: an emerging pivotal player in neuronal apoptosis and neurodegenerative disorders.
Journal of molecular neuroscience : MN 1999;13(1-2):17-30.
1999: WENZHEN DUAN; Mark P Mattson
Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease.
Journal of neuroscience research 1999;57(2):195-206.
1999: WENZHEN DUAN; Vivek M Rangnekar; Mark P Mattson
Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration.
Journal of neurochemistry 1999;72(6):2312-22.
1999: Jim G Begley; WENZHEN DUAN; S Chan; karen duff; Mark P Mattson
Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.
Journal of neurochemistry 1999;72(3):1030-9.
1999: Mark P Mattson; Ward Anthony Pedersen; WENZHEN DUAN; Carsten Culmsee; Simonetta Camandola
Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.
Annals of the New York Academy of Sciences 1999;893():154-75.
1998: WENZHEN DUAN; J Zhang
Effects of clausenamide on anisodine-induced acetylcholine decrease and memory deficits in the mouse brain.
Chinese medical journal 1998;111(11):1035-8.
1998: WENZHEN DUAN; JT Zhang
Stimulation of central cholinergic neurons by (-)clausenamide in vitro.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1998;19(4):332-6.
1998: WENZHEN DUAN; J Zhang
[Effects of (-), (+)clausenamide on anisodine-induced acetylcholine decrease and associated memory deficits in the mouse brain].
Yao xue xue bao = Acta pharmaceutica Sinica 1998;33(4):259-63.
1998: J T Zhang; WENZHEN DUAN; J F Wu
[Gene regulation of apoptosis and study of anti-neuronal apoptotic agents].
Yao xue xue bao = Acta pharmaceutica Sinica 1998;33(1):75-9.
1997: WENZHEN DUAN; Zhi-wei Qu; Jun-Tian Zhang
[Determination of acetylcholine by high performance liquid chromatography, enzyme-loaded postcolumn, and electrochemical detector].
Yao xue xue bao = Acta pharmaceutica Sinica 1997;32(12):920-3.
1997: WENZHEN DUAN; Jun-Tian Zhang
[Effects of (-), (+) clausenamide on central N-methyl-D-asparate receptors in rodents].
Yao xue xue bao = Acta pharmaceutica Sinica 1997;32(4):259-63.
1996: WENZHEN DUAN; Y Z Tang
Effects of methylflavonolamine on free intracellular calcium in isolated embryonic rat brain cells.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1996;17(4):305-8.