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johannes aerts

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J P J J Hegmans; Joris D Veltman; Eric T Fung; Thorsten Verch; Curtis Glover; Fujun Zhang; W Jeffrey Allard; Davy T'Jampens; Henk C Hoogsteden; Bart N Lambrecht; johannes aerts
Protein profiling of pleural effusions to identify malignant pleural mesothelioma using SELDI-TOF MS.
Anouk C Vedder; Frank Breunig; Wilma E Donker-Koopman; Kevin Mills; Elisabeth Young; Bryan Winchester; Ineke J M ten Berge; Johanna E M Groener; johannes aerts; Christoph Wanner; Carla E M Hollak
Treatment of Fabry disease with different dosing regimens of agalsidase: effects on antibody formation and GL-3.
Timothy M Cox; johannes aerts; N Belmatoug; M D Cappellini; Stephan vom Dahl; J Goldblatt; G A Grabowski; Carla E M Hollak; P Hwu; M Maas; A M Martins; P K Mistry; Gregory M Pastores; A Tylki-Szymanska; J Yee; N Weinreb
Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring.

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2009: J P J J Hegmans; Joris D Veltman; Eric T Fung; Thorsten Verch; Curtis Glover; Fujun Zhang; W Jeffrey Allard; Davy T'Jampens; Henk C Hoogsteden; Bart N Lambrecht; johannes aerts
Protein profiling of pleural effusions to identify malignant pleural mesothelioma using SELDI-TOF MS.
Technology in cancer research & treatment 2009;8(5):323-32.
2008: Anouk C Vedder; Frank Breunig; Wilma E Donker-Koopman; Kevin Mills; Elisabeth Young; Bryan Winchester; Ineke J M ten Berge; Johanna E M Groener; johannes aerts; Christoph Wanner; Carla E M Hollak
Treatment of Fabry disease with different dosing regimens of agalsidase: effects on antibody formation and GL-3.
Molecular genetics and metabolism 2008;94(3):319-25.
2008: Timothy M Cox; johannes aerts; N Belmatoug; M D Cappellini; Stephan vom Dahl; J Goldblatt; G A Grabowski; Carla E M Hollak; P Hwu; M Maas; A M Martins; P K Mistry; Gregory M Pastores; A Tylki-Szymanska; J Yee; N Weinreb
Management of non-neuronopathic Gaucher disease with special reference to pregnancy, splenectomy, bisphosphonate therapy, use of biomarkers and bone disease monitoring.
Journal of inherited metabolic disease 2008;31(3):319-36.
2008: M Biegstraaten; Ivo van Schaik; johannes aerts; Carla E M Hollak
'Non-neuronopathic' Gaucher disease reconsidered. Prevalence of neurological manifestations in a Dutch cohort of type I Gaucher disease patients and a systematic review of the literature.
Journal of inherited metabolic disease 2008;31(3):337-49.
2008: Maaike de Fost; T A Out; F A de Wilde; E P M Tjin; S T Pals; M H J van Oers; R G Boot; johannes aerts; Mario Maas; Stephan vom Dahl; Carla E M Hollak
Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature.
Annals of hematology 2008;87(6):439-49.
2008: Mirjam Langeveld; Maaike de Fost; johannes aerts; Hans P Sauerwein; Carla E M Hollak
Overweight, insulin resistance and type II diabetes in type I Gaucher disease patients in relation to enzyme replacement therapy.
Blood cells, molecules & diseases 2008;40(3):428-32.
2008: johannes aerts; Mariëlle J Van Breemen; Anton P Bussink; Karen Ghauharali; Richard Sprenger; Rolf G Boot; Johanna E M Groener; Carla E M Hollak; Mario Maas; Suzanne Smit; Huub C Hoefsloot; Age K Smilde; Johannes Pc Vissers; Sheryas de Jong; Dave Speijer; Chris G de Koster
Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2008;97(457):7-14.
2008: johannes aerts; Michael Beck; Rick Martin; MAURIZIO SCARPA
Seventh International Symposium on Lysosomal Storage Diseases.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2008;97(457):1-2.
2008: Anton P Bussink; Jocelyne Vreede; johannes aerts; Rolf G Boot
A single histidine residue modulates enzymatic activity in acidic mammalian chitinase.
FEBS letters 2008;582(6):931-5.
2008: Karen Ghauharali-van der Vlugt; Mirjam Langeveld; Aldi Poppema; Sijmen Kuiper; Carla E M Hollak; johannes aerts; Johanna E M Groener
Prominent increase in plasma ganglioside GM3 is associated with clinical manifestations of type I Gaucher disease.
Clinica chimica acta; international journal of clinical chemistry 2008;389(1-2):109-13.
2008: Mirjam Langeveld; Karen J M Ghauharali; Hans P Sauerwein; Mariëtte T Ackermans; Johanna E M Groener; Carla E M Hollak; johannes aerts; Mireille J Serlie
Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance.
The Journal of clinical endocrinology and metabolism 2008;93(3):845-51.
2008: johannes aerts; Johanna E M Groener; Sijmen Kuiper; Wilma E Donker-Koopman; Anneke Strijland; Roelof Ottenhoff; Cindy van Roomen; Mina Mirzaian; Frits A Wijburg; Gabor E Linthorst; Anouk C Vedder; Saskia M Rombach; J Cox-Brinkman; Pentti Somerharju; Rolf G Boot; Carla E M Hollak; Roscoe O Brady; B J H M Poorthuis
Elevated globotriaosylsphingosine is a hallmark of Fabry disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(8):2812-7.
2008: Johanna E M Groener; B J H M Poorthuis; Sijmen Kuiper; Carla E M Hollak; johannes aerts
Plasma glucosylceramide and ceramide in type 1 Gaucher disease patients: correlations with disease severity and response to therapeutic intervention.
Biochimica et biophysica acta 2008;1781(1-2):72-8.
2008: Boris Bleijlevens; Mariëlle J Van Breemen; Wilma E Donker-Koopman; Chris G de Koster; johannes aerts
Detection of mutant protein in complex biological samples: glucocerebrosidase mutations in Gaucher's disease.
Analytical biochemistry 2008;372(1):52-61.
2007: Martin van Eijk; Saskia Scheij; Cindy P A A van Roomen; Dave Speijer; Rolf G Boot; johannes aerts
TLR- and NOD2-dependent regulation of human phagocyte-specific chitotriosidase.
FEBS letters 2007;581(28):5389-95.
2007: Mirjam Langeveld; E Endert; W M Wiersinga; johannes aerts; Carla E M Hollak
Hypermetabolism in Gaucher disease type I is not associated with altered thyroid hormone levels.
Journal of inherited metabolic disease 2007;30(6):985.
2007: J Cox-Brinkman; R G M Timmermans; Frits A Wijburg; W E Donker; A T van de Ploeg; johannes aerts; Carla E M Hollak
Home treatment with enzyme replacement therapy for mucopolysaccharidosis type I is feasible and safe.
Journal of inherited metabolic disease 2007;30(6):984.
2007: Anouk C Vedder; V E A Gerdes; B J H M Poorthuis; Mariette T J Helmond; M D Trip; johannes aerts; Carla E M Hollak
Failure to detect Fabry patients in a cohort of prematurely atherosclerotic males.
Journal of inherited metabolic disease 2007;30(6):988.
2007: Margriet M W B Hendriks; Suzanne Smit; Wies L M W Akkermans; Theo H Reijmers; Paul H C Eilers; Huub C J Hoefsloot; Carina M Rubingh; Chris G de Koster; johannes aerts; Age K Smilde
How to distinguish healthy from diseased? Classification strategy for mass spectrometry-based clinical proteomics.
Proteomics 2007;7(20):3672-80.
2007: Anton P Bussink; Dave Speijer; johannes aerts; Rolf G Boot
Evolution of mammalian chitinase(-like) members of family 18 glycosyl hydrolases.
Genetics 2007;177(2):959-70.
2007: Deborah Elstein; Altoon Dweck; Drorit Attias; Irith Hadas-Halpern; Shoshana Zevin; Gheona Altarescu; johannes aerts; Sonja van Weely; Ari Zimran
Oral maintenance clinical trial with miglustat for type I Gaucher disease: switch from or combination with intravenous enzyme replacement.
Blood 2007;110(7):2296-301.
2007: Maarten R Soeters; Hans P Sauerwein; Johanna E M Groener; johannes aerts; Mariëtte T Ackermans; Jan F C Glatz; Eric Fliers; Mireille J Serlie
Gender-related differences in the metabolic response to fasting.
The Journal of clinical endocrinology and metabolism 2007;92(9):3646-52.
2007: Kerry Anne McEachern; John Fung; Svetlana Komarnitsky; Craig S Siegel; Wei-Lien Chuang; Elizabeth Hutto; James A Shayman; Gregory A Grabowski; johannes aerts; Seng Cheng; Diane P Copeland; John Marshall
A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher disease.
Molecular genetics and metabolism 2007;91(3):259-67.
2007: Mariëlle J Van Breemen; Maaike de Fost; Jane S A Voerman; Jon D Laman; Rolf G Boot; Mario Maas; Carla E M Hollak; johannes aerts; Farhad Rezaee
Increased plasma macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels in type 1 Gaucher disease.
Biochimica et biophysica acta 2007;1772(7):788-96.
2007: Suzanne Smit; Mariëlle J Van Breemen; Huub C J Hoefsloot; Age K Smilde; johannes aerts; Chris G de Koster
Assessing the statistical validity of proteomics based biomarkers.
Analytica chimica acta 2007;592(2):210-7.
2007: Carla E M Hollak; Anouk C Vedder; Gabor E Linthorst; johannes aerts
Novel therapeutic targets for the treatment of Fabry disease.
Expert opinion on therapeutic targets 2007;11(6):821-33.
2007: Aricha Schoonhoven; Bernard Rudensky; Debbie Elstein; Ari Zimran; Carla E M Hollak; Johanna E M Groener; johannes aerts
Monitoring of Gaucher patients with a novel chitotriosidase assay.
Clinica chimica acta; international journal of clinical chemistry 2007;381(2):136-9.
2007: Anton P Bussink; Paul F van Swieten; Karen Ghauharali; Saskia Scheij; Martin van Eijk; Tom Wennekes; Gijsbert A van der Marel; Rolf G Boot; johannes aerts; Herman S Overkleeft
N-azidoacetylmannosamine-mediated chemical tagging of gangliosides.
Journal of lipid research 2007;48(6):1417-21.
2007: Johannes P C Vissers; James I Langridge; johannes aerts
Analysis and quantification of diagnostic serum markers and protein signatures for Gaucher disease.
Molecular & cellular proteomics : MCP 2007;6(5):755-66.
2007: johannes aerts; Roelof Ottenhoff; Andrew S Powlson; Aldo Grefhorst; Martin van Eijk; Peter F Dubbelhuis; Jan Aten; Folkert Kuipers; Mireille J Serlie; Tom Wennekes; Jaswinder Sethi; Stephen O'Rahilly; Herman S Overkleeft
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.
Diabetes 2007;56(5):1341-9.
2007: Johanna E M Groener; B J H M Poorthuis; Sijmen Kuiper; Mariette T J Helmond; Carla E M Hollak; johannes aerts
HPLC for simultaneous quantification of total ceramide, glucosylceramide, and ceramide trihexoside concentrations in plasma.
Clinical chemistry 2007;53(4):742-7.
2007: Mireille J Serlie; Alfred J Meijer; Johanna E M Groener; M Duran; Erik Endert; Eric Fliers; johannes aerts; Hans P Sauerwein
Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects.
The Journal of clinical endocrinology and metabolism 2007;92(4):1524-9.
2007: Mirjam Langeveld; Saskia Scheij; Peter F Dubbelhuis; Carla E M Hollak; Hans P Sauerwein; Peter Simons; johannes aerts
Very low serum adiponectin levels in patients with type 1 Gaucher disease without overt hyperglycemia.
Metabolism: clinical and experimental 2007;56(3):314-9.
2007: Tom Wennekes; Richard J B H N van den Berg; Wilma Donker; Gijsbert A van der Marel; Anneke Strijland; johannes aerts; Herman S Overkleeft
Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.
The Journal of organic chemistry 2007;72(4):1088-97.
2007: Maaike de Fost; johannes aerts; Johanna E M Groener; Mario Maas; Erik M Akkerman; Maaike G Wiersma; Carla E M Hollak
Low frequency maintenance therapy with imiglucerase in adult type I Gaucher disease: a prospective randomized controlled trial.
Haematologica 2007;92(2):215-21.
2007: Peter J Simons; Petra S van den Pangaart; johannes aerts; Louis Boon
Pro-inflammatory delipidizing cytokines reduce adiponectin secretion from human adipocytes without affecting adiponectin oligomerization.
The Journal of endocrinology 2007;192(2):289-99.
2007: Anouk C Vedder; Gabor E Linthorst; Mariëlle J Van Breemen; Johanna E M Groener; F J Bemelman; Anneke Strijland; marcel mannens; johannes aerts; Carla E M Hollak
The Dutch Fabry cohort: diversity of clinical manifestations and Gb3 levels.
Journal of inherited metabolic disease 2007;30(1):68-78.
2007: Rolf G Boot; Marri Verhoek; Wilma Donker-Koopman; Anneke Strijland; Jan van Marle; Herman S Overkleeft; Tom Wennekes; johannes aerts
Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.
The Journal of biological chemistry 2007;282(2):1305-12.
2007: Johannes Levels; Boris Bleijlevens; Farhad Rezaee; johannes aerts; Joost Cm Meijers
SELDI-TOF mass spectrometry of High-Density Lipoprotein.
Proteome science 2007;5():15.
2007: Anouk C Vedder; Gabor E Linthorst; Gunnar Houge; Johanna E M Groener; Els E Ormel; Berto J Bouma; johannes aerts; Asle Hirth; Carla E M Hollak
Treatment of Fabry disease: outcome of a comparative trial with agalsidase alfa or beta at a dose of 0.2 mg/kg.
PloS one 2007;2(7):e598.
2007: Carla E M Hollak; Maaike de Fost; johannes aerts; Stephan vom Dahl
Low-dose versus high-dose therapy for Gaucher disease: Goals and markers.
Blood 2007;109(1):387; author reply 387-8.
2007: Mireille J Serlie; Gideon Allick; Johanna E M Groener; Mariëtte T Ackermans; Rik Heijligenberg; Barbara C Voermans; johannes aerts; Alfred J Meijer; Hans P Sauerwein
Chronic treatment with pioglitazone does not protect obese patients with diabetes mellitus type II from free fatty acid-induced insulin resistance.
The Journal of clinical endocrinology and metabolism 2007;92(1):166-71.
2006: Mario Maas; Carla E M Hollak; Erik M Akkerman; johannes aerts
Radiology of Gaucher disease (type 1) and bone manifestations: the Dutch experience.
JBR-BTR : organe de la Société royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) 2006;89(6):318-21.
2006: Anouk C Vedder; J Cox-Brinkman; Carla E M Hollak; Gabor E Linthorst; Johanna E M Groener; Mariette T J Helmond; Saskia Scheij; johannes aerts
Plasma chitotriosidase in male Fabry patients: a marker for monitoring lipid-laden macrophages and their correction by enzyme replacement therapy.
Molecular genetics and metabolism 2006;89(3):239-44.
2006: Mariëlle J Van Breemen; Boris Bleijlevens; Chris G de Koster; johannes aerts
Limitations in quantitation of the biomarker CCL18 in Gaucher disease blood samples by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.
Biochimica et biophysica acta 2006;1764(10):1626-32.
2006: Rolf G Boot; Marri Verhoek; Mirjam Langeveld; G Herma Renkema; Carla E M Hollak; Jan J Weening; Wilma E Donker-Koopman; Johanna E M Groener; johannes aerts
CCL18: a urinary marker of Gaucher cell burden in Gaucher patients.
Journal of inherited metabolic disease 2006;29(4):564-71.
2006: Maaike de Fost; Carla E M Hollak; Johanna E M Groener; johannes aerts; Mario Maas; Ludger W Poll; Maaike G Wiersma; Dieter Häussinger; Sarah Brett; Nicole Brill; Stephan vom Dahl
Superior effects of high-dose enzyme replacement therapy in type 1 Gaucher disease on bone marrow involvement and chitotriosidase levels: a 2-center retrospective analysis.
Blood 2006;108(3):830-5.
2006: johannes aerts; Carla E M Hollak; Rolf G Boot; Johanna E M Groener; Mario Maas
Substrate reduction therapy of glycosphingolipid storage disorders.
Journal of inherited metabolic disease 2006;29(2-3):449-56.
2006: Anouk C Vedder; Anneke Strijland; M A vd Bergh Weerman; S Florquin; johannes aerts; Carla E M Hollak
Manifestations of Fabry disease in placental tissue.
Journal of inherited metabolic disease 2006;29(1):106-11.
2006: Leonie A Boven; Marjan van Meurs; Marloes Van Zwam; Annet F Wierenga-Wolf; Rogier Q Hintzen; Rolf G Boot; johannes aerts; Sandra Amor; Edward E S Nieuwenhuis; Jon D Laman
Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis.
Brain : a journal of neurology 2006;129(Pt 2):517-26.
2006: Gabor E Linthorst; Anouk C Vedder; Els E Ormel; johannes aerts; Carla E M Hollak
Home treatment for Fabry disease: practice guidelines based on 3 years experience in The Netherlands.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006;21(2):355-60.
2006: Anton P Bussink; Martin van Eijk; G Herma Renkema; johannes aerts; Rolf G Boot
The biology of the Gaucher cell: the cradle of human chitinases.
International review of cytology 2006;252():71-128.
2005: Martin van Eijk; Cindy P A A van Roomen; G Herma Renkema; Anton P Bussink; Laura Andrews; Edward F C Blommaart; Alan Sugar; Arthur J Verhoeven; Rolf G Boot; johannes aerts
Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity.
International immunology 2005;17(11):1505-12.
2005: Evagelia Dimitriou; Marri Verhoek; S Altun; Fotis Karabatsos; Marina Moraitou; J Youssef; Rolf G Boot; Jasmin Sarafidou; Markisia Karagiorga; johannes aerts; Helen Michelakakis
Elevated plasma chemokine CCL18/PARC in beta-thalassemia.
Blood cells, molecules & diseases 2005;35(3):328-31.
2005: Martina Schmitz; Marwan Alfalah; johannes aerts; Hassan Y Naim; Klaus-Peter Zimmer
Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease.
The international journal of biochemistry & cell biology 2005;37(11):2310-20.
2005: Peter J Simons; Petra S van den Pangaart; Cindy P A A van Roomen; johannes aerts; Louis Boon
Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-alpha- and interleukin-1beta-treated human preadipocytes are potent leptin producers.
Cytokine 2005;32(2):94-103.
2005: Rolf G Boot; Anton P Bussink; Marri Verhoek; Piet A J de Boer; Antoon F M Moorman; johannes aerts
Marked differences in tissue-specific expression of chitinases in mouse and man.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(10):1283-92.
2005: Carla E M Hollak; Rolf G Boot; B J H M Poorthuis; johannes aerts
[From gene to disease; Gaucher disease].
Nederlands tijdschrift voor geneeskunde 2005;149(39):2163-6.
2005: Patrick B Deegan; Mary Teresa Moran; Ian McFarlane; J Paul Schofield; Rolf G Boot; johannes aerts; Timothy M Cox
Clinical evaluation of chemokine and enzymatic biomarkers of Gaucher disease.
Blood cells, molecules & diseases 2005;35(2):259-67.
2005: Rolf G Boot; Anton P Bussink; johannes aerts
Human acidic mammalian chitinase erroneously known as eosinophil chemotactic cytokine is not the ortholog of mouse YM1.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2041-2.
2005: Russell R Lonser; Stuart Walbridge; Gary J Murray; Michele R Aizenberg; Alexander O Vortmeyer; johannes aerts; Roscoe O Brady; Edward H Oldfield
Convection perfusion of glucocerebrosidase for neuronopathic Gaucher's disease.
Annals of neurology 2005;57(4):542-8.
2005: johannes aerts; Carla E M Hollak; Mariëlle J Van Breemen; Mario Maas; Johanna E M Groener; Rolf G Boot
Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases.
Acta paediatrica (Oslo, Norway : 1992). Supplement 2005;94(447):43-6; discussion 37-8.
2005: Gabor E Linthorst; Anouk C Vedder; johannes aerts; Carla E M Hollak
Screening for Fabry disease using whole blood spots fails to identify one-third of female carriers.
Clinica chimica acta; international journal of clinical chemistry 2005;353(1-2):201-3.
2005: J Brinkman; Frits A Wijburg; Carla E M Hollak; Johanna E M Groener; Marri Verhoek; Saskia Scheij; J Aten; Rolf G Boot; johannes aerts
Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.
Journal of inherited metabolic disease 2005;28(1):13-20.
2005: Francesco V Rao; Douglas R Houston; Rolf G Boot; johannes aerts; Michael Hodkinson; David J Adams; Kazuro Shiomi; Satoshi Omura; Daan M F van Aalten
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.
Chemistry & biology 2005;12(1):65-76.
2004: Gregory M Pastores; Neal J Weinreb; johannes aerts; Generoso Andria; Timothy M Cox; Manuel Giralt; Gregory A Grabowski; Pramod Mistry; Anna Tylki-Szymańska
Therapeutic goals in the treatment of Gaucher disease.
Seminars in hematology 2004;41(4 Suppl 5):4-14.
2004: Gabor E Linthorst; Carla E M Hollak; Wilma E Donker-Koopman; Anneke Strijland; johannes aerts
Enzyme therapy for Fabry disease: neutralizing antibodies toward agalsidase alpha and beta.
Kidney international 2004;66(4):1589-95.
2004: Leonie A Boven; Marjan van Meurs; Rolf G Boot; Atul Mehta; Louis Boon; johannes aerts; Jon D Laman
Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages.
American journal of clinical pathology 2004;122(3):359-69.
2004: Chong Shen; dominique ma bullens; Ahmad Kasran; Philippe Maerten; Louis Boon; johannes aerts; Gert van Assche; Karel Geboes; Paul Rutgeerts; Jan L Ceuppens
Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis.
International immunopharmacology 2004;4(7):939-51.
2004: Gabor E Linthorst; M A De Rie; K H Tjiam; johannes aerts; KP Dingemans; Carla E M Hollak
Misdiagnosis of Fabry disease: importance of biochemical confirmation of clinical or pathological suspicion.
The British journal of dermatology 2004;150(3):575-7.
2004: Richard J B H N van den Berg; Wilma Donker-Koopman; Jacques H van Boom; johannes aerts; Daan Noort
Design and synthesis of 2-acetamidomethyl derivatives of isofagomine as potential inhibitors of human lysosomal beta-hexosaminidases.
Bioorganic & medicinal chemistry 2004;12(5):891-902.
2004: Holger Jon Møller; Maaike de Fost; johannes aerts; Carla E M Hollak; Søren K Moestrup
Plasma level of the macrophage-derived soluble CD163 is increased and positively correlates with severity in Gaucher's disease.
European journal of haematology 2004;72(2):135-9.
2004: Deborah Elstein; Carla E M Hollak; johannes aerts; Sonja van Weely; M Maas; Timothy M Cox; Robin H Lachmann; Martin Hrebicek; Frances M Platt; Terry D Butters; Raymond A Dwek; Ari Zimran
Sustained therapeutic effects of oral miglustat (Zavesca, N-butyldeoxynojirimycin, OGT 918) in type I Gaucher disease.
Journal of inherited metabolic disease 2004;27(6):757-66.
2004: Rolf G Boot; Marri Verhoek; Maaike de Fost; Carla E M Hollak; Mario Maas; Boris Bleijlevens; Mariëlle J Van Breemen; Marjan van Meurs; Leonie A Boven; Jon D Laman; Mary Teresa Moran; Timothy M Cox; johannes aerts
Marked elevation of the chemokine CCL18/PARC in Gaucher disease: a novel surrogate marker for assessing therapeutic intervention.
Blood 2004;103(1):33-9.
2003: Gabor E Linthorst; Claudia C Folman; johannes aerts; Carla E M Hollak
Blood group does not correlate with disease severity in patients with Fabry disease (alpha-galactosidase A deficiency).
Blood cells, molecules & diseases 2003;31(3):324-6.
2003: Mario Maas; Cornelis van Kuijk; Jaap Stoker; Carla E M Hollak; Erik M Akkerman; johannes aerts; Gerard J den Heeten
Quantification of bone involvement in Gaucher disease: MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging--initial experience.
Radiology 2003;229(2):554-61.
2003: Begoña Aguilera; Karen Ghauharali-van der Vlugt; Mariette T J Helmond; Jos M M Out; Wilma E Donker-Koopman; Johanna E M Groener; Rolf G Boot; G Herma Renkema; Gijsbert A van der Marel; Jacques H van Boom; Herman S Overkleeft; johannes aerts
Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase.
The Journal of biological chemistry 2003;278(42):40911-6.
2003: Gabor E Linthorst; Carla E M Hollak; Johanna C Korevaar; Jeannette G van Manen; johannes aerts; Elisabeth Boeschoten
alpha-Galactosidase A deficiency in Dutch patients on dialysis: a critical appraisal of screening for Fabry disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2003;18(8):1581-4.
2003: Francesco V Rao; Douglas R Houston; Rolf G Boot; johannes aerts; Shohei Sakuda; Daan M F van Aalten
Crystal structures of allosamidin derivatives in complex with human macrophage chitinase.
The Journal of biological chemistry 2003;278(22):20110-6.
2003: johannes aerts; Carla E M Hollak; Rolf G Boot; Ans Groener
Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1433):905-14.
2003: Timothy M Cox; johannes aerts; Generoso Andria; Michael Beck; N Belmatoug; Bruno Bembi; R Chertkoff; Stephan vom Dahl; Deborah Elstein; Anders Erikson; M Giralt; Rene Heitner; Carla E M Hollak; Martin Hrebicek; S Lewis; Atul Mehta; Gregory M Pastores; Arndt Rolfs; M. Clara Sá-Miranda; Ari Zimran
The role of the iminosugar N-butyldeoxynojirimycin (miglustat) in the management of type I (non-neuronopathic) Gaucher disease: a position statement.
Journal of inherited metabolic disease 2003;26(6):513-26.
2003: Maaike de Fost; johannes aerts; Carla E M Hollak
Gaucher disease: from fundamental research to effective therapeutic interventions.
The Netherlands journal of medicine 2003;61(1):3-8.
2003: Daniël Blom; Dave Speijer; Gabor E Linthorst; Wilma Donker-Koopman; Anneke Strijland; johannes aerts
Recombinant enzyme therapy for Fabry disease: absence of editing of human alpha-galactosidase A mRNA.
American journal of human genetics 2003;72(1):23-31.
2002: Mario Maas; Carla E M Hollak; Erik M Akkerman; johannes aerts; Jaap Stoker; Gerard J den Heeten
Quantification of skeletal involvement in adults with type I Gaucher's disease: fat fraction measured by Dixon quantitative chemical shift imaging as a valid parameter.
AJR. American journal of roentgenology 2002;179(4):961-5.
2002: Fabrizia Fusetti; Holger von Moeller; Douglas Houston; Henriëtte J Rozeboom; Bauke W Dijkstra; Rolf G Boot; johannes aerts; Daan M F van Aalten
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins.
The Journal of biological chemistry 2002;277(28):25537-44.
2002: Ludger W Poll; Jens-Albrecht Koch; Reinhart Willers; johannes aerts; Axel Scherer; Dieter Häussinger; Ulrich Mödder; Stephan vom Dahl
Correlation of bone marrow response with hematological, biochemical, and visceral responses to enzyme replacement therapy of nonneuronopathic (type 1) Gaucher disease in 30 adult patients.
Blood cells, molecules & diseases 2002;28(2):209-20.
2002: Rene Heitner; Deborah Elstein; johannes aerts; Sonja van Weely; Ari Zimran
Low-dose N-butyldeoxynojirimycin (OGT 918) for type I Gaucher disease.
Blood cells, molecules & diseases 2002;28(2):127-33.
2002: Holger Jon Møller; johannes aerts; H Grønbaek; Niels Anker Peterslund; P Hyltoft Petersen; Nete Hornung; L Rejnmark; E Jabbarpour; Søren K Moestrup
Soluble CD163: a marker molecule for monocyte/macrophage activity in disease.
Scandinavian journal of clinical and laboratory investigation. Supplementum 2002;237():29-33.
2001: Carla E M Hollak; M Maas; E Akkerman; A den Heeten; johannes aerts
Dixon quantitative chemical shift imaging is a sensitive tool for the evaluation of bone marrow responses to individualized doses of enzyme supplementation therapy in type 1 Gaucher disease.
Blood cells, molecules & diseases 2001;27(6):1005-12.
2001: Marina Moraitou; Sonja van Weely; Marri Verhoek; johannes aerts; Evagelia Dimitriou; Helen Michelakakis
The facile detection of 1505G-->A in Gaucher patients with different phenotypes.
Biochimica et biophysica acta 2001;1536(2-3):97-102.
2001: Frances M Platt; Mylvaganam Jeyakumar; Ulrika Andersson; David A Priestman; Raymond A Dwek; Terry D Butters; Timothy M Cox; Robin H Lachmann; Carla E M Hollak; johannes aerts; Sonja van Weely; M Hrebícek; C Moyses; I Gow; Deborah Elstein; Ari Zimran
Inhibition of substrate synthesis as a strategy for glycolipid lysosomal storage disease therapy.
Journal of inherited metabolic disease 2001;24(2):275-90.
2001: Rolf G Boot; Edward F C Blommaart; E Swart; K Ghauharali-van der Vlugt; N Bijl; C Moe; Allen R Place; johannes aerts
Identification of a novel acidic mammalian chitinase distinct from chitotriosidase.
The Journal of biological chemistry 2001;276(9):6770-8.
2001: Carla E M Hollak; M Maas; johannes aerts
Clinically relevant therapeutic endpoints in type I Gaucher disease.
Journal of inherited metabolic disease 2001;24 Suppl 2():97-105; discussion 87-8.
2001: Nicole Baumann; Mireille Lefèvre; J C Turpin; B Fontaine; H Hosseini; johannes aerts; S Van Weekly
Atypical course of neuropathic Gaucher's disease: follow up from early infancy until adulthood.
Journal of neurology, neurosurgery, and psychiatry 2001;70(1):133-4.
2000: Gabor E Linthorst; Carla E M Hollak; D K Bosman; Hugo S A Heymans; johannes aerts
[Fabry's disease; towards a treatment].
Nederlands tijdschrift voor geneeskunde 2000;144(50):2391-5.
2000: T Cox; Robin H Lachmann; Carla E M Hollak; johannes aerts; Sonja van Weely; M Hrebícek; Frances M Platt; Terry D Butters; Raymond A Dwek; C Moyses; I Gow; Deborah Elstein; Ari Zimran
Novel oral treatment of Gaucher's disease with N-butyldeoxynojirimycin (OGT 918) to decrease substrate biosynthesis.
Lancet 2000;355(9214):1481-5.
2000: P Maaswinkel-Mooij; Carla E M Hollak; M van Eysden-Plaisier; M Prins; johannes aerts; Ruud G Pöll
The natural course of Gaucher disease in The Netherlands: implications for monitoring of disease manifestations.
Journal of inherited metabolic disease 2000;23(1):77-82.
1999: Daphne A Van Sluijters; George M Van Woerkom; johannes aerts; Alfred J Meijer
Sphingomyelinase treatment of rat hepatocytes inhibits cell-swelling-stimulated glycogen synthesis by causing cell shrinkage.
European journal of biochemistry / FEBS 1999;266(2):653-9.
1999: Stephan vom Dahl; Klaus Harzer; Arndt Rolfs; B Albrecht; Claus Niederau; Christoph Vogt; Sonja van Weely; johannes aerts; G Müller; Dieter Häussinger
Hepatosplenomegalic lipidosis: what unless Gaucher? Adult cholesteryl ester storage disease (CESD) with anemia, mesenteric lipodystrophy, increased plasma chitotriosidase activity and a homozygous lysosomal acid lipase -1 exon 8 splice junction mutation.
Journal of hepatology 1999;31(4):741-6.
1999: Klaus-Peter Zimmer; P le Coutre; johannes aerts; Klaus Harzer; M Fukuda; John S O'Brien; Hassan Y Naim
Intracellular transport of acid beta-glucosidase and lysosome-associated membrane proteins is affected in Gaucher's disease (G202R mutation).
The Journal of pathology 1999;188(4):407-14.
1999: Fanny N Lauw; Anje A Te Velde; Pascale E P Dekkers; Peter Speelman; johannes aerts; C Erik Hack; Sander J H van Deventer; Tom van der Poll
Activation of mononuclear cells by interleukin-12: an in vivo study in chimpanzees.
Journal of clinical immunology 1999;19(4):231-8.
1999: Rolf G Boot; Tanja A E Van Achterberg; Benien E van Aken; G Herma Renkema; Michael J Jacobs; johannes aerts; Carlie J M de Vries
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):687-94.
1998: Annet van Royen-Kerkhof; Bwee Tien Poll-The; W J Kleijer; O P van Diggelen; johannes aerts; J J Hopwood; F A Beemer
Coexistence of Gaucher disease type 1 and Joubert syndrome.
Journal of medical genetics 1998;35(11):965-6.
1998: Herman S Overkleeft; G Herma Renkema; Jolanda M Neele; P Vianello; I O Hung; Anneke Strijland; Alida M van der Burg; Gerrit-Jan Koomen; U K Pandit; johannes aerts
Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase.
The Journal of biological chemistry 1998;273(41):26522-7.
1998: Rolf G Boot; G Herma Renkema; Marri Verhoek; Anneke Strijland; Jet Bliek; T M de Meulemeester; marcel mannens; johannes aerts
The human chitotriosidase gene. Nature of inherited enzyme deficiency.
The Journal of biological chemistry 1998;273(40):25680-5.
1998: J Labadaridis; Evagelia Dimitriou; Christos Costalos; johannes aerts; Sonja van Weely; W E Donker-Koopman; Helen Michelakakis
Serial chitotriosidase activity estimations in neonatal systemic candidiasis.
Acta paediatrica (Oslo, Norway : 1992) 1998;87(5):605.
1998: Jan G N de Jong; johannes aerts; Sonja van Weely; Carla E M Hollak; J van Pelt; L M van Woerkom; Maria L F Liebrand-van Sambeek; Ron A Wevers
Oligosaccharide excretion in adult Gaucher disease.
Journal of inherited metabolic disease 1998;21(1):49-59.
1998: G Herma Renkema; Rolf G Boot; F L Au; Wilma E Donker-Koopman; Anneke Strijland; Anton O Muijsers; Martin Hrebicek; johannes aerts
Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.
European journal of biochemistry / FEBS 1998;251(1-2):504-9.
1998: Carla E M Hollak; johannes aerts; Marinus H J van Oers
Alglucerase: practical guidance on appropriate dosage and administration in patients with Gaucher disease.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 1998;9(1):11-23.
1997: johannes aerts; Carla E M Hollak
Plasma and metabolic abnormalities in Gaucher's disease.
Baillière's clinical haematology 1997;10(4):691-709.
1997: Raphael Schiffmann; M P Heyes; johannes aerts; James Dambrosia; M C Patterson; Thomas J DeGraba; CC Parker; GC Zirzow; KL Oliver; Gioacchino Tedeschi; Roscoe O Brady; Norman W Barton
Prospective study of neurological responses to treatment with macrophage-targeted glucocerebrosidase in patients with type 3 Gaucher's disease.
Annals of neurology 1997;42(4):613-21.
1997: Carla E M Hollak; E P Corssmit; johannes aerts; Erik Endert; Hans P Sauerwein; Johannes A Romijn; Marinus H J van Oers
Differential effects of enzyme supplementation therapy on manifestations of type 1 Gaucher disease.
The American journal of medicine 1997;103(3):185-91.
1997: Katerina Hodanová; Martin Hrebícek; M Cervenková; johannes aerts; Jirí Zeman
Incorrect assignment of N370S mutation status by mismatched PCR/RFLP method in two Gaucher patients.
Journal of inherited metabolic disease 1997;20(4):611-2.
1997: Carla E M Hollak; Ludo M Evers; johannes aerts; Marinus H J van Oers
Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease.
Blood cells, molecules & diseases 1997;23(2):201-12.
1997: Metsada Pasmanik-Chor; Liora Madar-Shapiro; E O Stein; johannes aerts; Shimon Gatt; Mia Horowitz
Expression of mutated glucocerebrosidase alleles in human cells.
Human molecular genetics 1997;6(6):887-95.
1997: G Herma Renkema; Rolf G Boot; Anneke Strijland; Wilma E Donker-Koopman; M van den Berg; Anton O Muijsers; johannes aerts
Synthesis, sorting, and processing into distinct isoforms of human macrophage chitotriosidase.
European journal of biochemistry / FEBS 1997;244(2):279-85.
1997: Carla E M Hollak; M Levi; F Berends; johannes aerts; Marinus H J van Oers
Coagulation abnormalities in type 1 Gaucher disease are due to low-grade activation and can be partly restored by enzyme supplementation therapy.
British journal of haematology 1997;96(3):470-6.
1997: Rolf G Boot; Carla E M Hollak; Marri Verhoek; P Sloof; B J H M Poorthuis; Wim J Kleijer; Ron A Wevers; Marinus H J van Oers; marcel mannens; johannes aerts; Sonja van Weely
Glucocerebrosidase genotype of Gaucher patients in The Netherlands: limitations in prognostic value.
Human mutation 1997;10(5):348-58.
1996: Helen Michelakakis; C Spanou; A Kondyli; Evagelia Dimitriou; Sonja van Weely; Carla E M Hollak; Marinus H J van Oers; johannes aerts
Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease.
Biochimica et biophysica acta 1996;1317(3):219-22.
1996: Martin Hrebícek; Jirí Zeman; J Musilová; Katerina Hodanová; G Herma Renkema; L Vepreková; Jana Ledvinová; D Hrebícek; Jitka Sokolová; johannes aerts; Milan Elleder
A case of type I Gaucher disease with cardiopulmonary amyloidosis and chitotriosidase deficiency.
Virchows Archiv : an international journal of pathology 1996;429(4-5):305-9.
1996: M Mikhaylova; G Wiederschain; V Mikhaylov; johannes aerts
The enzymatic hydrolysis of 6-acylamino-4-methylumbelliferyl-beta-D-glucosides: identification of a novel human acid beta-glucosidase.
Biochimica et biophysica acta 1996;1317(1):71-9.
1996: Metsada Pasmanik-Chor; Orna Elroy-Stein; johannes aerts; V Agmon; Shimon Gatt; Mia Horowitz
Overexpression of human glucocerebrosidase containing different-sized leaders.
The Biochemical journal 1996;317 ( Pt 1)():81-8.
1996: Carla E M Hollak; Marinus H J van Oers; P Maaswinkel; johannes aerts; R Goudsmit
[The treatment of Gaucher's disease in The Netherlands using enzyme substitution therapy].
Nederlands tijdschrift voor geneeskunde 1996;140(19):1011-3.
1996: Mar Fernandez-Borja; Desiree Verwoerd; F Sanderson; johannes aerts; J Trowsdale; A Tulp; Jacques Neefjes
HLA-DM and MHC class II molecules co-distribute with peptidase-containing lysosomal subcompartments.
International immunology 1996;8(5):625-40.
1996: Martin K Bijsterbosch; W Donker; H van de Bilt; Sonja van Weely; Theo Van berkel; johannes aerts
Quantitative analysis of the targeting of mannose-terminal glucocerebrosidase. Predominant uptake by liver endothelial cells.
European journal of biochemistry / FEBS 1996;237(2):344-9.
1996: J J Luiken; johannes aerts; Alfred J Meijer
The role of the intralysosomal pH in the control of autophagic proteolytic flux in rat hepatocytes.
European journal of biochemistry / FEBS 1996;235(3):564-73.
1996: D K Bosman; Carla E M Hollak; johannes aerts; H D Bakker
The effect of enzyme therapy in a patient with Gaucher disease type III.
Journal of inherited metabolic disease 1996;19(5):703-4.
1995: Rolf G Boot; G Herma Renkema; Anneke Strijland; Anton-Jan van Zonneveld; johannes aerts
Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages.
The Journal of biological chemistry 1995;270(44):26252-6.
1995: Carla E M Hollak; johannes aerts; R Goudsmit; Saffire S K S Phoa; M Ek; Sonja van Weely; Albert E G Kr von dem Borne; Marinus H J van Oers
Individualised low-dose alglucerase therapy for type 1 Gaucher's disease.
Lancet 1995;345(8963):1474-8.
1995: G Herma Renkema; Rolf G Boot; Anton O Muijsers; Wilma E Donker-Koopman; johannes aerts
Purification and characterization of human chitotriosidase, a novel member of the chitinase family of proteins.
The Journal of biological chemistry 1995;270(5):2198-202.
1995: Y Guo; W He; A M Boer; Ron A Wevers; A M de Bruijn; Johanna E M Groener; Carla E M Hollak; johannes aerts; H Galjaard; Otto P van Diggelen
Elevated plasma chitotriosidase activity in various lysosomal storage disorders.
Journal of inherited metabolic disease 1995;18(6):717-22.
1995: Helen Michelakakis; Evagelia Dimitriou; Sonja van Weely; Rolf G Boot; I Mavridou; Marri Verhoek; johannes aerts
Characterization of glucocerebrosidase in Greek Gaucher disease patients: mutation analysis and biochemical studies.
Journal of inherited metabolic disease 1995;18(5):609-15.
1994: H H van Es; H Renkema; johannes aerts; Erwin Schurr
Enhanced lysosomal acidification leads to increased chloroquine accumulation in CHO cells expressing the pfmdr1 gene.
Molecular and biochemical parasitology 1994;68(2):209-19.
1994: Luiz D Lacerda; Olga Amaral; Rui Aguiar Pinto; P Oliveira; johannes aerts; M. Clara Sá-Miranda
Gaucher disease: N370S glucocerebrosidase gene frequency in the Portuguese population.
Clinical genetics 1994;45(6):298-300.
1994: Carla E M Hollak; Sonja van Weely; Marinus H J van Oers; johannes aerts
Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease.
The Journal of clinical investigation 1994;93(3):1288-92.
1994: Luiz D Lacerda; Olga Amaral; Rui Aguiar Pinto; johannes aerts; M. Clara Sá-Miranda
The N370S mutation in the glucocerebrosidase gene of Portuguese type 1 Gaucher patients: linkage to the PvuII polymorphism.
Journal of inherited metabolic disease 1994;17(1):85-8.
1994: J M Tager; johannes aerts; C van den Bogert; R J Wanders
Signals on proteins, intracellular targeting and inborn errors of organellar metabolism.
Journal of inherited metabolic disease 1994;17(4):459-69.
1993: Luiz D Lacerda; Olga Amaral; Rui Aguiar Pinto; johannes aerts; M. Clara Sá-Miranda
Identification of Gaucher disease carriers: glucocerebrosidase antigen and DNA analysis.
Biochemical medicine and metabolic biology 1993;50(2):190-6.
1993: Carla E M Hollak; johannes aerts; Marinus H J van Oers
Treatment of Gaucher's disease.
The New England journal of medicine 1993;328(21):1565-6; author reply 1567.
1993: Sonja van Weely; M Brandsma; Anneke Strijland; J M Tager; johannes aerts
Demonstration of the existence of a second, non-lysosomal glucocerebrosidase that is not deficient in Gaucher disease.
Biochimica et biophysica acta 1993;1181(1):55-62.
1993: Nico P M Smit; Carlo W T van Roermund; johannes aerts; J C Heikoop; Marlene van den Berg; Stan Pavel; R J Wanders
Subcellular fractionation of cultured normal human melanocytes: new insights into the relationship of melanosomes with lysosomes and peroxisomes.
Biochimica et biophysica acta 1993;1181(1):1-6.
1993: Sonja van Weely; Marlene van den Berg; J A Barranger; M C Sa Miranda; J M Tager; johannes aerts
Role of pH in determining the cell-type-specific residual activity of glucocerebrosidase in type 1 Gaucher disease.
The Journal of clinical investigation 1993;91(3):1167-75.
1993: Olga Amaral; Luiz D Lacerda; R Santos; Rui Aguiar Pinto; johannes aerts; M C Sa Miranda
Type 1 Gaucher disease: molecular, biochemical, and clinical characterization of patients from northern Portugal.
Biochemical medicine and metabolic biology 1993;49(1):97-107.
1993: johannes aerts; Sonja van Weely; Rolf G Boot; Carla E M Hollak; J M Tager
Pathogenesis of lysosomal storage disorders as illustrated by Gaucher disease.
Journal of inherited metabolic disease 1993;16(2):288-91.
1991: johannes aerts; M C Sa Miranda; L Wanzeller de Lacerda; Sonja van Weely; Wilma E Donker-Koopman; B Brouwer-Kelder; D C Jansen; M van Leeuwen; M. Clara Sá-Miranda; A Tsiapara
The identification of type 1 Gaucher disease patients, asymptomatic cases and carriers in The Netherlands using urine samples: an evaluation.
Clinica chimica acta; international journal of clinical chemistry 1991;203(2-3):349-61.
1991: S Rijnboutt; A J Kal; Hans J Geuze; johannes aerts; Ger J Strous
Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.
The Journal of biological chemistry 1991;266(35):23586-92.
1991: Carla E M Hollak; johannes aerts; R Goudsmit
[Gaucher's disease; current developments in the treatment of lysosomal metabolic disease].
Nederlands tijdschrift voor geneeskunde 1991;135(46):2162-4.
1991: S Rijnboutt; johannes aerts; Hans J Geuze; J M Tager; Ger J Strous
Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells.
The Journal of biological chemistry 1991;266(8):4862-8.
1991: T Ohashi; C M Hong; S Weiler; J M Tomich; johannes aerts; J M Tager; J A Barranger
Characterization of human glucocerebrosidase from different mutant alleles.
The Journal of biological chemistry 1991;266(6):3661-7.
1990: johannes aerts; M C Sa Miranda; E M Brouwer-Kelder; M. Clara Sá-Miranda; J A Barranger; J M Tager
Conditions affecting the activity of glucocerebrosidase purified from spleens of control subjects and patients with type 1 Gaucher disease.
Biochimica et biophysica acta 1990;1041(1):55-63.
1990: M C Sa Miranda; johannes aerts; Rui Aguiar Pinto; A Fontes; L W de Lacerda; M. Clara Sá-Miranda; J Barranger; J M Tager
Activity of glucocerebrosidase in extracts of different cell types from type 1 Gaucher disease patients.
Clinical genetics 1990;38(3):218-27.
1990: Sonja van Weely; johannes aerts; M B Van Leeuwen; J C Heikoop; Wilma E Donker-Koopman; J A Barranger; J M Tager; A W Schram
Function of oligosaccharide modification in glucocerebrosidase, a membrane-associated lysosomal hydrolase.
European journal of biochemistry / FEBS 1990;191(3):669-77.
1990: johannes aerts; Wilma E Donker-Koopman; S Brul; Sonja van Weely; M C Sa Miranda; J A Barranger; J M Tager; M. Clara Sá-Miranda
Comparative study on glucocerebrosidase in spleens from patients with Gaucher disease.
The Biochemical journal 1990;269(1):93-100.
1988: Rob Willemsen; J M van Dongen; johannes aerts; A W Schram; J M Tager; R Goudsmit; Arnold J J Reuser
An immunoelectron microscopic study of glucocerebrosidase in type 1 Gaucher's disease spleen.
Ultrastructural pathology 1988;12(5):471-8.
1988: johannes aerts; J Heikoop; Sonja van Weely; Wilma E Donker-Koopman; J A Barranger; J M Tager; A W Schram
Characterization of glucocerebrosidase in peripheral blood cells and cultured blastoid cells.
Experimental cell research 1988;177(2):391-8.
1988: M C Sa Miranda; johannes aerts; Rui Aguiar Pinto; J A Magalhaes; J A Barranger; J M Tager; M. Clara Sá-Miranda
Heterogeneity in human acid beta-glucosidase revealed by cellulose-acetate electrophoresis.
Biochimica et biophysica acta 1988;965(2-3):163-8.
1988: johannes aerts; A W Schram; Anneke Strijland; Sonja van Weely; L M Jonsson; J M Tager; S H Sorrell; E I Ginns; J A Barranger; G J Murray
Glucocerebrosidase, a lysosomal enzyme that does not undergo oligosaccharide phosphorylation.
Biochimica et biophysica acta 1988;964(3):303-8.
1987: L M Jonsson; G J Murray; S H Sorrell; Anneke Strijland; johannes aerts; E I Ginns; J A Barranger; J M Tager; A W Schram
Biosynthesis and maturation of glucocerebrosidase in Gaucher fibroblasts.
European journal of biochemistry / FEBS 1987;164(1):171-9.
1987: johannes aerts; Wilma E Donker-Koopman; C van Laar; S Brul; G J Murray; D A Wenger; J A Barranger; J M Tager; A W Schram
Relationship between the two immunologically distinguishable forms of glucocerebrosidase in tissue extracts.
European journal of biochemistry / FEBS 1987;163(3):583-9.
1986: johannes aerts; S Brul; Wilma E Donker-Koopman; Sonja van Weely; G J Murray; J A Barranger; J M Tager; A W Schram
Efficient routing of glucocerebrosidase to lysosomes requires complex oligosaccharide chain formation.
Biochemical and biophysical research communications 1986;141(2):452-8.
1986: johannes aerts; Wilma E Donker-Koopman; M Koot; G J Murray; J A Barranger; J M Tager; A W Schram
Comparison of the properties of a soluble form of glucocerebrosidase from human urine with those of the membrane-associated tissue enzyme.
Biochimica et biophysica acta 1986;863(1):63-70.
1986: johannes aerts; Wilma E Donker-Koopman; M Koot; J A Barranger; J M Tager; A W Schram
Deficient activity of glucocerebrosidase in urine from patients with type 1 Gaucher disease.
Clinica chimica acta; international journal of clinical chemistry 1986;158(2):155-63.
1986: johannes aerts; Wilma E Donker-Koopman; G J Murray; J A Barranger; J M Tager; A W Schram
A procedure for the rapid purification in high yield of human glucocerebrosidase using immunoaffinity chromatography with monoclonal antibodies.
Analytical biochemistry 1986;154(2):655-63.
1985: johannes aerts; Wilma E Donker-Koopman; M K van der Vliet; L M Jonsson; E I Ginns; G J Murray; J A Barranger; J M Tager; A W Schram
The occurrence of two immunologically distinguishable beta-glucocerebrosidases in human spleen.
European journal of biochemistry / FEBS 1985;150(3):565-74.
1985: johannes aerts; A M Lauwers; W Heinen
Temperature-dependent lipid content and fatty acid composition of three thermophilic bacteria.
Antonie van Leeuwenhoek 1985;51(2):155-65.
1984: J M Tager; L V Jonsson; johannes aerts; R P Elferink; A W Schram; Ann H Erickson; J A Barranger
Metabolic consequences of genetic defects in lysosomes.
Biochemical Society transactions 1984;12(6):902-5.