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Robert Gould

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Joseph J Lynch; You-Tang Shen; Tamara J Pittman; Kenneth D Anderson; Kenneth S Koblan; Robert Gould; Christopher P Regan; Stefanie A Kane
Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs.
J Fred Hess; Richard W Ransom; Zhizhen Zeng; Raymond S L Chang; Patricia J Hey; Lee Warren; Charles M Harrell; Kathy L Murphy; Tsing-Bau Chen; Patricia J Miller; Edward V Lis; Duane R Reiss; Raymond E Gibson; M Kristine Markowitz; Robert M DiPardo; Dai-Shi Su; Mark G Bock; Robert Gould; Douglas J Pettibone
Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model.
You-Tang Shen; John J Mallee; Larry Handt; David B Gilberto; Joseph J Lynch; Richard Hargreaves; Kenneth S Koblan; Robert Gould; Stefanie A Kane
Effects of inhibition of alpha-CGRP receptors on cardiac and peripheral vascular dynamics in conscious dogs with chronic heart failure.

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All Publications

2009: Joseph J Lynch; You-Tang Shen; Tamara J Pittman; Kenneth D Anderson; Kenneth S Koblan; Robert Gould; Christopher P Regan; Stefanie A Kane
Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs.
European journal of pharmacology 2009;623(1-3):96-102.
2004: J Fred Hess; Richard W Ransom; Zhizhen Zeng; Raymond S L Chang; Patricia J Hey; Lee Warren; Charles M Harrell; Kathy L Murphy; Tsing-Bau Chen; Patricia J Miller; Edward V Lis; Duane R Reiss; Raymond E Gibson; M Kristine Markowitz; Robert M DiPardo; Dai-Shi Su; Mark G Bock; Robert Gould; Douglas J Pettibone
Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model.
The Journal of pharmacology and experimental therapeutics 2004;310(2):488-97.
2003: You-Tang Shen; John J Mallee; Larry Handt; David B Gilberto; Joseph J Lynch; Richard Hargreaves; Kenneth S Koblan; Robert Gould; Stefanie A Kane
Effects of inhibition of alpha-CGRP receptors on cardiac and peripheral vascular dynamics in conscious dogs with chronic heart failure.
Journal of cardiovascular pharmacology 2003;42(5):656-61.
2003: You-Tang Shen; Joseph J Lynch; Richard Hargreaves; Robert Gould
A growth hormone secretagogue prevents ischemic-induced mortality independently of the growth hormone pathway in dogs with chronic dilated cardiomyopathy.
The Journal of pharmacology and experimental therapeutics 2003;306(2):815-20.
2002: Philippe G Nantermet; James C Barrow; George F Lundell; Janetta M Pellicore; Kenneth E Rittle; MaryBeth Young; Roger M Freidinger; Thomas M Connolly; Cindra L Condra; Jerzy Karczewski; Rodney A Bednar; Stanley L Gaul; Robert Gould; Kris Prendergast; Harold G Selnick
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).
Bioorganic & medicinal chemistry letters 2002;12(3):319-23.
2001: You-Tang Shen; T J Pittman; P S Buie; D L Bolduc; Stefanie A Kane; Kenneth S Koblan; Robert Gould; Joseph J Lynch
Functional role of alpha-calcitonin gene-related peptide in the regulation of the cardiovascular system.
The Journal of pharmacology and experimental therapeutics 2001;298(2):551-8.
2001: Kang Zhang; MF Kniazeva; Min Han; W Li; Z Yu; Zhenglin Yang; Yingying Li; Michael Metzker; Rando Allikmets; Donald J Zack; Laura E Kakuk; Pamela S Lagali; Paul W Wong; Ian M MacDonald; Paul Sieving; David Figueroa; Christopher P Austin; Robert Gould; Radha Ayyagari; Konstantin Petrukhin
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.
Nature genetics 2001;27(1):89-93.
2000: You-Tang Shen; RT Wiedmann; Joseph J Lynch; Robert Gould
Platelet glycoprotein IIb/IIIa receptor inhibitor preserves coronary flow reserve during progressive coronary arteriostenosis in swine.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(10):2309-15.
2000: Melissa S Egbertson; Bohumil Bednar; Ben C Askew; Rodney A Bednar; Karen M Brashear; Michael J Breslin; Mark E Duggan; Thorsten E Fisher; Wasyl Halczenko; John H Hutchinson; Nathan C Ihle; J D Prugh; John S Wai; Robert Gould; George D Hartman
Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors.
Bioorganic & medicinal chemistry letters 2000;10(17):1943-8.
1999: Joseph J Lynch; Gary L Stump; Audrey A Wallace; C A Painter; J M Thomas; S E Kusma; Robert Gould; W Grossman
EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction.
Journal of the American College of Cardiology 1999;34(3):876-84.
1999: Bohumil Bednar; Jacquelynn J Cook; Marie A Holahan; Michael E Cunningham; P A Jumes; Rodney A Bednar; George D Hartman; Robert Gould
Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa.
Blood 1999;94(2):587-99.
1999: Melissa S Egbertson; Jacquelynn J Cook; Bohumil Bednar; J D Prugh; Rodney A Bednar; Stanley L Gaul; Robert Gould; George D Hartman; Carl F Homnick; Marie A Holahan; L A Libby; Joseph J Lynch; RJ Lynch; Gary R Sitko; Maria T Stranieri; L M Vassallo
Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation.
Journal of medicinal chemistry 1999;42(13):2409-21.
1999: George D Hartman; Mark E Duggan; William F Hoffman; R J Meissner; James J Perkins; Amy E Zartman; Adel M Naylor-Olsen; Jacquelynn J Cook; JD Glass; RJ Lynch; G Zhang; Robert Gould
Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(6):863-8.
1998: Rodney A Bednar; Stanley L Gaul; Terence G Hamill; Melissa S Egbertson; Jules A Shafer; George D Hartman; Robert Gould; Bohumil Bednar
Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1317-26.
1998: Nigel J Liverton; D J Armstrong; David A Claremon; D C Remy; JJ Baldwin; RJ Lynch; G Zhang; Robert Gould
Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
Bioorganic & medicinal chemistry letters 1998;8(5):483-6.
1997: Jacquelynn J Cook; JD Glass; Gary R Sitko; Marie A Holahan; R F Stupienski; Audrey A Wallace; Gary L Stump; Elizabeth Hand; Ben C Askew; George D Hartman; Robert Gould; Joseph J Lynch
Nonpeptide glycoprotein IIb/IIIa inhibitors: 14: oral antithrombotic efficacy of L-738,167 in a conscious canine model of coronary artery electrolytic injury.
Circulation 1997;96(3):949-58.
1997: D G Abraham; E M Nutt; Rodney A Bednar; Bohumil Bednar; Robert Gould; LT Duong
Arginine-glycine-aspartic acid mimics can identify a transitional activation state of recombinant alphaIIb beta3 in human embryonic kidney 293 cells.
Molecular pharmacology 1997;52(2):227-36.
1997: Ben C Askew; Rodney A Bednar; Bohumil Bednar; David A Claremon; Jacquelynn J Cook; Charles J McIntyre; Cecilia A Hunt; Robert Gould; RJ Lynch; Joseph J Lynch; Stanley L Gaul; Maria T Stranieri; Gary R Sitko; Marie A Holahan; JD Glass; Terence G Hamill; LM Gorham; Thomayant Prueksaritanont; JJ Baldwin; George D Hartman
Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.
Journal of medicinal chemistry 1997;40(12):1779-88.
1997: Jacquelynn J Cook; Gary R Sitko; Marie A Holahan; Maria T Stranieri; JD Glass; Ben C Askew; Charles J McIntyre; David A Claremon; JJ Baldwin; George D Hartman; Robert Gould; Joseph J Lynch
Nonpeptide glycoprotein IIb/IIIa inhibitors. 15. Antithrombotic efficacy of L-738,167, a long-acting GPIIb/IIIa antagonist, correlates with inhibition of adenosine diphosphate-induced platelet aggregation but not with bleeding time prolongation.
The Journal of pharmacology and experimental therapeutics 1997;281(2):677-89.
1997: Bohumil Bednar; Michael E Cunningham; P A McQueney; Melissa S Egbertson; Ben C Askew; Rodney A Bednar; George D Hartman; Robert Gould
Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets.
Cytometry 1997;28(1):58-65.
1997: Y Hiramatsu; Nicolas Gikakis; HL Anderson; Joseph H Gorman; Cezary Marcinkiewicz; Robert Gould; Stefan Niewiarowski; L Henry Edmunds
Tirofiban provides "platelet anesthesia" during cardiopulmonary bypass in baboons.
The Journal of thoracic and cardiovascular surgery 1997;113(1):182-93.
1996: John H Hutchinson; Jacquelynn J Cook; K M Brashear; Michael J Breslin; JD Glass; Robert Gould; W Halczenko; Marie A Holahan; RJ Lynch; Gary R Sitko; Maria T Stranieri; George D Hartman
Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.
Journal of medicinal chemistry 1996;39(23):4583-91.
1996: Jacquelynn J Cook; Marie A Holahan; Elizabeth A Lyle; D R Ramjit; Gary R Sitko; Maria T Stranieri; R F Stupienski; Audrey A Wallace; Elizabeth Hand; J R Gehret; T Kothstein; M D Drag; G Y McCormick; J J Perkins; N C Ihle; M E Duggan; George D Hartman; Robert Gould; Joseph J Lynch
Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217.
The Journal of pharmacology and experimental therapeutics 1996;278(1):62-73.
1995: M E Duggan; Adel M Naylor-Olsen; J J Perkins; P S Anderson; C T Chang; Jacquelynn J Cook; Robert Gould; N C Ihle; George D Hartman; Joseph J Lynch
Non-peptide fibrinogen receptor antagonists. 7. Design and synthesis of a potent, orally active fibrinogen receptor antagonist.
Journal of medicinal chemistry 1995;38(17):3332-41.
1995: Jacquelynn J Cook; Gary R Sitko; Bohumil Bednar; C Condra; M J Mellott; D M Feng; R F Nutt; Jules A Shafer; Robert Gould; T M Connolly
An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey.
Circulation 1995;91(12):2961-71.
1995: Bohumil Bednar; C Condra; Robert Gould; T M Connolly
Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists.
Thrombosis research 1995;77(5):453-63.
1994: J S Barrett; G Murphy; Kathelijne Peerlinck; Inge De Lepeleire; Robert Gould; D Panebianco; Elizabeth Hand; Hans Deckmyn; Jos Vermylen; Jef Arnout
Pharmacokinetics and pharmacodynamics of MK-383, a selective non-peptide platelet glycoprotein-IIb/IIIa receptor antagonist, in healthy men.
Clinical pharmacology and therapeutics 1994;56(4):377-88.
1994: T M Connolly; C Condra; D M Feng; Jacquelynn J Cook; Maria T Stranieri; C F Reilly; R F Nutt; Robert Gould
Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides.
Thrombosis and haemostasis 1994;72(4):627-33.
1994: M Sato; Victor M Garsky; Robert J Majeska; T A Einhorn; J Murray; A H Tashjian; Robert Gould
Structure-activity studies of the s-echistatin inhibition of bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(9):1441-9.
1994: Melissa S Egbertson; C T Chang; M E Duggan; Robert Gould; W Halczenko; George D Hartman; W L Laswell; Joseph J Lynch; RJ Lynch; P D Manno
Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp.
Journal of medicinal chemistry 1994;37(16):2537-51.
1994: J S Barrett; Robert Gould; Joan D Ellis; M M Holahan; Maria T Stranieri; Joseph J Lynch; George D Hartman; N Ihle; M Duggan; O A Moreno
Pharmacokinetics and pharmacodynamics of L-703,014, a potent fibrinogen receptor antagonist, after intravenous and oral administration in the dog.
Pharmaceutical research 1994;11(3):426-31.
1993: L W Schaffer; J T Davidson; Peter K S Siegl; Robert Gould; R F Nutt; Stephen F Brady; T M Connolly
Recombinant leech antiplatelet protein prevents collagen-mediated platelet aggregation but not collagen graft thrombosis in baboons.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(11):1593-601.
1993: John E Fisher; M P Caulfield; M Sato; H A Quartuccio; Robert Gould; Victor M Garsky; Gideon A Rodan; M Rosenblatt
Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing protein.
Endocrinology 1993;132(3):1411-3.
1992: J D Frank; Robert Gould; L W Schaffer; J T Davidson; R E Gibson; D H Patrick; S L Vonderfecht; M E Cartwright
Immunocytochemical localization of platelets in baboon hepatic sinusoids using monoclonal mouse anti-human platelet glycoprotein IIIa following induction of thrombocytopenia.
Histochemistry 1992;97(4):355-60.
1990: Robert Gould; M A Polokoff; P A Friedman; T F Huang; J C Holt; Jacquelynn J Cook; S Niewiarowski
Disintegrins: a family of integrin inhibitory proteins from viper venoms.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1990;195(2):168-71.
1990: M Sato; Mohinder K Sardana; W A Grasser; Victor M Garsky; J M Murray; Robert Gould
Echistatin is a potent inhibitor of bone resorption in culture.
The Journal of cell biology 1990;111(4):1713-23.
1990: Robert Gould; C Fioravanti; P G Cook; H F Solomon
A model of gastric emptying in cats shows solid emptying is promoted by MK-329: a CCK antagonist.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(9):1494-9.
1990: Claudia Derian; Robert Gould; P A Friedman
Proaggregatory effect of epinephrine on rabbit platelets inhibited by ticlopidine.
Thrombosis research 1990;57(3):393-403.
1989: M A Jacobson; F M Forma; R F Buenaga; K J Hofmann; Loren D Schultz; Robert Gould; P A Friedman
Expression and secretion of biologically active echistatin in Saccharomyces cerevisiae.
Gene 1989;85(2):511-6.
1989: Robert Gould; K M Murphy; Solomon H Snyder; J W Strandhoy; C E Dunlap
Differential interaction of guanabenz with receptor binding sites in rat brain and kidney.
Research communications in chemical pathology and pharmacology 1989;66(1):3-19.
1989: Z R Gan; Jon H Condra; Robert Gould; R A Zivin; C D Bennett; J W Jacobs; P A Friedman; M A Polokoff
High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28]echistatin.
Gene 1989;79(1):159-66.
1989: Victor M Garsky; P K Lumma; Roger M Freidinger; Steven M Pitzenberger; W C Randall; D F Veber; Robert Gould; P A Friedman
Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4022-6.
1989: Rebecca Taub; Robert Gould; Victor M Garsky; T M Ciccarone; J Hoxie; P A Friedman; Sanford J Shattil
A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen.
The Journal of biological chemistry 1989;264(1):259-65.
1989: A W Mangel; K M Sanders; D Jevsevar; Robert Gould; S V Pineo; S Wiese; Richard A Gillis
Exaggeration of the cholecystokinin-induced motor response in the cat gastrointestinal tract.
Digestion 1989;43(4):196-203.
1988: Z R Gan; Robert Gould; J W Jacobs; P A Friedman; M A Polokoff
Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus.
The Journal of biological chemistry 1988;263(36):19827-32.
1987: R G Pendleton; R J Bendesky; L Schaffer; T E Nolan; Robert Gould; B V Clineschmidt
Roles of endogenous cholecystokinin in biliary, pancreatic and gastric function: studies with L-364,718, a specific cholecystokinin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 1987;241(1):110-6.
1987: V J Lotti; R G Pendleton; Robert Gould; H M Hanson; R S Chang; B V Clineschmidt
In vivo pharmacology of L-364,718, a new potent nonpeptide peripheral cholecystokinin antagonist.
The Journal of pharmacology and experimental therapeutics 1987;241(1):103-9.
1985: Robert Gould; K M Murphy; Solomon H Snyder
Autoradiographic localization of calcium channel antagonist receptors in rat brain with [3H]nitrendipine.
Brain research 1985;330(2):217-23.
1985: Jay M Baraban; Robert Gould; S J Peroutka; Solomon H Snyder
Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(2):604-7.
1984: I J Reynolds; Robert Gould; Solomon H Snyder
Loperamide: blockade of calcium channels as a mechanism for antidiarrheal effects.
The Journal of pharmacology and experimental therapeutics 1984;231(3):628-32.
1984: Robert Gould; K M Murphy; Solomon H Snyder
Tissue heterogeneity of calcium channel antagonist binding sites labeled by [3H]nitrendipine.
Molecular pharmacology 1984;25(2):235-41.
1984: Robert Gould; K M Murphy; I J Reynolds; Solomon H Snyder
Calcium channel blockade: possible explanation for thioridazine's peripheral side effects.
The American journal of psychiatry 1984;141(3):352-7.
1984: Robert Gould; K M Murphy; Jefferson Katims; Solomon H Snyder
Caffeine actions and adenosine.
Psychopharmacology bulletin 1984;20(3):436-40.
1983: Robert Gould; K M Murphy; Solomon H Snyder
A simple sensitive radioreceptor assay for calcium antagonist drugs.
Life sciences 1983;33(26):2665-72.
1983: K M Murphy; Robert Gould; M L Oster-Granite; John D Gearhart; Solomon H Snyder
Phorbol ester receptors: autoradiographic identification in the developing rat.
Science (New York, N.Y.) 1983;222(4627):1036-8.
1983: I J Reynolds; Robert Gould; Solomon H Snyder
[3H]Verapamil binding sites in brain and skeletal muscle: regulation by calcium.
European journal of pharmacology 1983;95(3-4):319-21.
1983: Robert Gould; K M Murphy; I J Reynolds; Solomon H Snyder
Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(16):5122-5.
1983: K M Murphy; Robert Gould; B L Largent; Solomon H Snyder
A unitary mechanism of calcium antagonist drug action.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(3):860-4.
1983: Robert Gould; K M Murphy; Solomon H Snyder
Studies on voltage-operated calcium channels using radioligands.
Cold Spring Harbor symposia on quantitative biology 1983;48 Pt 1():355-62.
1982: K M Murphy; Robert Gould; Solomon H Snyder
Autoradiographic visualization of [3H]nitrendipine binding sites in rat brain: localization to synaptic zones.
European journal of pharmacology 1982;81(3):517-9.
1982: Robert Gould; K M Murphy; Solomon H Snyder
[3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(11):3656-60.
1982: Robert Gould; barry gisnberg; A A Spector
Lipid effects on the binding properties of a reconstituted insulin receptor.
The Journal of biological chemistry 1982;257(1):477-84.
1981: Robert Gould; barry gisnberg; A A Spector
Effects of octyl beta-glucoside on insulin binding to solubilized membrane receptors.
Biochemistry 1981;20(24):6776-81.
1979: Robert Gould; barry gisnberg; A A Spector
Reconstitution of the solubilized insulin receptor in phospholipid vesicles.
Endocrine research communications 1979;6(4):279-90.