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Brian Kennedy

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Joe R Delaney; Marissa Fletcher; Sean Higgins; Monika Jelic; Umema Ahmed; Elroy H An; Daniel Carr; Anthony Castanza; Annie Chou; Brian Kennedy; Shannon Klum; Brian Muller; Christopher J Murakami; Zhao J Peng; Dilreet Rai; Vanessa Ros; Jennifer Schleit; Sylvia Sim; Minnie Singh; George L Sutphin; Helen V Wende; Matt Kaeberlein
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Fresnida J Ramos; Matt Kaeberlein; Brian Kennedy
Elevated MTORC1 signaling and impaired autophagy.
Fresnida J Ramos; Katherine H Schreiber; Randy Strong; Elroy H An; Steven C Chen; Dao-Fu Dai; Michael G Garelick; Matt Kaeberlein; Warren C Ladiges; Chen-Yu Liao; Vivian L MacKay; Peter S Rabinovitch; Brian Kennedy
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

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All Publications

2013: Joe R Delaney; Marissa Fletcher; Sean Higgins; Monika Jelic; Umema Ahmed; Elroy H An; Daniel Carr; Anthony Castanza; Annie Chou; Brian Kennedy; Shannon Klum; Brian Muller; Christopher J Murakami; Zhao J Peng; Dilreet Rai; Vanessa Ros; Jennifer Schleit; Sylvia Sim; Minnie Singh; George L Sutphin; Helen V Wende; Matt Kaeberlein
Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
Aging cell 2013;12(1):156-66.
2013: Fresnida J Ramos; Matt Kaeberlein; Brian Kennedy
Elevated MTORC1 signaling and impaired autophagy.
Autophagy 2013;9(1):108-9.
2012: Fresnida J Ramos; Katherine H Schreiber; Randy Strong; Elroy H An; Steven C Chen; Dao-Fu Dai; Michael G Garelick; Matt Kaeberlein; Warren C Ladiges; Chen-Yu Liao; Vivian L MacKay; Peter S Rabinovitch; Brian Kennedy
Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.
Science translational medicine 2012;4(144):144ra103.
2012: Kristan K Steffen; Joe R Delaney; Matt Kaeberlein; Vivian L MacKay; Mark A McCormick; Christopher J Murakami; Kim M Pham; Brian Kennedy
Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae.
Genetics 2012;191(1):107-18.
2012: Daniel Lockshon; Daniel A Lorenz; Alexey J Merz; Carissa Perez Olsen; Marc R Van Gilst; Christopher L Brett; Andrei Chertov; Brian Kennedy
Rho signaling participates in membrane fluidity homeostasis.
PloS one 2012;7(10):e45049.
2012: Richard L Frock; Christina Brown; Steven C Chen; Dao-Fu Da; Ellie Frett; Warren C Ladiges; Carmen Lau; Antoine Muchir; Diana N Pak; Peter S Rabinovitch; Luis F Santana; Yuexia Wang; Howard J Worman; Brian Kennedy
Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.
PloS one 2012;7(8):e42918.
2011: Brian Kennedy
The Buck Institute: an inside look.
Cell cycle (Georgetown, Tex.) 2011;10(24):4177-8.
2011: Christopher R Burtner; Christopher J Murakami; Brady Olsen; Brian Kennedy; Matt Kaeberlein
A genomic analysis of chronological longevity factors in budding yeast.
Cell cycle (Georgetown, Tex.) 2011;10(9):1385-96.
2011: Matt Kaeberlein; Brian Kennedy
Hot topics in aging research: protein translation and TOR signaling, 2010.
Aging cell 2011;10(2):185-90.
2011: Michael G Garelick; Brian Kennedy
TOR on the brain.
Experimental gerontology 2011;46(2-3):155-63.
2011: Steven C Chen; Ellie Frett; Joseph Marx; Darko Bosnakovski; Xylena Reed; Michael Kyba; Brian Kennedy
Decreased proliferation kinetics of mouse myoblasts overexpressing FRG1.
PloS one 2011;6(5):e19780.
2011: Joe R Delaney; Christopher J Murakami; Brady Olsen; Brian Kennedy; Matt Kaeberlein
Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.
Cell cycle (Georgetown, Tex.) 2011;10(1):156-65.
2010: Mark A McCormick; Brian Kennedy
Old yeast can't handle the noise.
Molecular cell 2010;39(5):659-61.
2010: Christopher R Burtner; Brian Kennedy
Progeria syndromes and ageing: what is the connection?
Nature reviews. Molecular cell biology 2010;11(8):567-78.
2009: Linda C Enns; John F Morton; Ruby Sue Mangalindan; G Stanley McKnight; Michael W Schwartz; Matt R Kaeberlein; Brian Kennedy; Peter S Rabinovitch; Warren C Ladiges
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(12):1221-31.
2009: Brian Kennedy; Matt Kaeberlein
Hot topics in aging research: protein translation, 2009.
Aging cell 2009;8(6):617-23.
2009: Brian Kennedy; Vivian L MacKay
Translate this ... during dietary restriction.
Cell metabolism 2009;10(4):247-8.
2009: Monique N Stanfel; Lara S Shamieh; Matt Kaeberlein; Brian Kennedy
The TOR pathway comes of age.
Biochimica et biophysica acta 2009;1790(10):1067-74.
2009: Tom Schmidlin; Brian Kennedy; Valerie Daggett
Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V.
Biophysical journal 2009;97(6):1709-18.
2009: Christopher R Burtner; Christopher J Murakami; Brian Kennedy; Matt Kaeberlein
A molecular mechanism of chronological aging in yeast.
Cell cycle (Georgetown, Tex.) 2009;8(8):1256-70.
2009: Damian C Lee; K Linnea Welton; Erica D Smith; Brian Kennedy
A-type nuclear lamins act as transcriptional repressors when targeted to promoters.
Experimental cell research 2009;315(6):996-1007.
2009: Kristan K Steffen; Brian Kennedy; Matt Kaeberlein
Measuring replicative life span in the budding yeast.
Journal of visualized experiments : JoVE 2009;(28):.
2008: Brian A Kudlow; Monique N Stanfel; Christopher R Burtner; Elijah D Johnston; Brian Kennedy
Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53.
Molecular biology of the cell 2008;19(12):5238-48.
2008: Matt Kaeberlein; Brian Kennedy
Protein translation, 2008.
Aging cell 2008;7(6):777-82.
2008: Katherine A Steinkraus; Erica D Smith; Christina Davis; Daniel Carr; William R Pendergrass; George L Sutphin; Brian Kennedy; Matt Kaeberlein
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.
Aging cell 2008;7(3):394-404.
2008: Kristan K Steffen; Vivian L MacKay; Emily O Kerr; Mitsuhiro Tsuchiya; Di Hu; Lindsay A Fox; Nick Dang; Elijah D Johnston; Jonathan A Oakes; Bie N Tchao; Diana N Pak; Stanley Fields; Brian Kennedy; Matt Kaeberlein
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
Cell 2008;133(2):292-302.
2008: Erica D Smith; Mitsuhiro Tsuchiya; Lindsay A Fox; Nick Dang; Di Hu; Emily O Kerr; Elijah D Johnston; Bie N Tchao; Diana N Pak; K Linnea Welton; Daniel E L Promislow; James H Thomas; Matt Kaeberlein; Brian Kennedy
Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
Genome research 2008;18(4):564-70.
2008: Tom Schmidlin; Matt Kaeberlein; Brian A Kudlow; Vivian MacKay; Daniel Lockshon; Brian Kennedy
Single-gene deletions that restore mating competence to diploid yeast.
FEMS yeast research 2008;8(2):276-86.
2008: Christopher J Murakami; Christopher R Burtner; Brian Kennedy; Matt Kaeberlein
A method for high-throughput quantitative analysis of yeast chronological life span.
The journals of gerontology. Series A, Biological sciences and medical sciences 2008;63(2):113-21.
2008: Brian Kennedy
The genetics of ageing: insight from genome-wide approaches in invertebrate model organisms.
Journal of internal medicine 2008;263(2):142-52.
2008: Erica D Smith; Tammi L Kaeberlein; Brynn T Lydum; Jennifer Sager; K Linnea Welton; Brian Kennedy; Matt Kaeberlein
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.
BMC developmental biology 2008;8():49.
2007: Matt Kaeberlein; Brian Kennedy
Protein translation, 2007.
Aging cell 2007;6(6):731-4.
2007: Matt Kaeberlein; Brian Kennedy
Does resveratrol activate yeast Sir2 in vivo?
Aging cell 2007;6(4):415-6.
2007: Brian Kennedy; Kristan K Steffen; Matt Kaeberlein
Ruminations on dietary restriction and aging.
Cellular and molecular life sciences : CMLS 2007;64(11):1323-8.
2007: Matt Kaeberlein; Christopher R Burtner; Brian Kennedy
Recent developments in yeast aging.
PLoS genetics 2007;3(5):e84.
2007: Brian A Kudlow; Brian Kennedy; Raymond J Monnat
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.
Nature reviews. Molecular cell biology 2007;8(5):394-404.
2007: Ryan T Nitta; Catherine L Smith; Brian Kennedy
Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2.
PloS one 2007;2(9):e963.
2007: Daniel Lockshon; Lauren E Surface; Emily O Kerr; Matt Kaeberlein; Brian Kennedy
The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function.
Genetics 2007;175(1):77-91.
2007: Erica D Smith; Brian Kennedy; Matt Kaeberlein
Genome-wide identification of conserved longevity genes in yeast and worms.
Mechanisms of ageing and development 2007;128(1):106-11.
2006: Mitsuhiro Tsuchiya; Nick Dang; Emily O Kerr; Di Hu; Kristan K Steffen; Jonathan A Oakes; Brian Kennedy; Matt Kaeberlein
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.
Aging cell 2006;5(6):505-14.
2006: Tammi L Kaeberlein; Erica D Smith; Mitsuhiro Tsuchiya; K Linnea Welton; James H Thomas; Stanley Fields; Brian Kennedy; Matt Kaeberlein
Lifespan extension in Caenorhabditis elegans by complete removal of food.
Aging cell 2006;5(6):487-94.
2006: Brian A Kudlow; Brian Kennedy
Aging: progeria and the lamin connection.
Current biology : CB 2006;16(16):R652-4.
2006: Valter D Longo; Brian Kennedy
Sirtuins in aging and age-related disease.
Cell 2006;126(2):257-68.
2006: Ryan T Nitta; Samantha A Jameson; Brian A Kudlow; Lindus A Conlan; Brian Kennedy
Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.
Molecular and cellular biology 2006;26(14):5360-72.
2006: Yanfei Xu; Cindy G Leung; D C Lee; Brian Kennedy; John D Crispino
MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation.
Leukemia 2006;20(7):1261-9.
2006: Matt Kaeberlein; Kristan K Steffen; Di Hu; Nick Dang; Emily O Kerr; Mitsuhiro Tsuchiya; Stanley Fields; Brian Kennedy
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".
Science (New York, N.Y.) 2006;312(5778):1312; author reply 1312.
2006: Richard L Frock; Brian A Kudlow; Angela M Evans; Samantha A Jameson; Stephen D Hauschka; Brian Kennedy
Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation.
Genes & development 2006;20(4):486-500.
2006: R Wilson Powers; Matt Kaeberlein; Seth D Caldwell; Brian Kennedy; Stanley Fields
Extension of chronological life span in yeast by decreased TOR pathway signaling.
Genes & development 2006;20(2):174-84.
2005: Matt Kaeberlein; R Wilson Powers; Kristan K Steffen; Eric A Westman; Di Hu; Nick Dang; Emily O Kerr; Kathryn T Kirkland; Stanley Fields; Brian Kennedy
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Science (New York, N.Y.) 2005;310(5751):1193-6.
2005: Brian Kennedy; Erica D Smith; Matt Kaeberlein
The enigmatic role of Sir2 in aging.
Cell 2005;123(4):548-50.
2005: Matt Kaeberlein; Di Hu; Emily O Kerr; Mitsuhiro Tsuchiya; Eric A Westman; Nick Dang; Stanley Fields; Brian Kennedy
Increased life span due to calorie restriction in respiratory-deficient yeast.
PLoS genetics 2005;1(5):e69.
2005: Brian A Kudlow; Samantha A Jameson; Brian Kennedy
HIV protease inhibitors block adipocyte differentiation independently of lamin A/C.
AIDS (London, England) 2005;19(15):1565-73.
2005: David A Barbie; Lindus A Conlan; Brian Kennedy
Nuclear tumor suppressors in space and time.
Trends in cell biology 2005;15(7):378-85.
2005: Matt Kaeberlein; Thomas McDonagh; Birgit Heltweg; Jeffrey Hixon; Eric A Westman; Seth D Caldwell; Andrew D Napper; Rory Curtis; Peter S DiStefano; Stanley Fields; Antonio Bedalov; Brian Kennedy
Substrate-specific activation of sirtuins by resveratrol.
The Journal of biological chemistry 2005;280(17):17038-45.
2005: Matt Kaeberlein; Kathryn T Kirkland; Stanley Fields; Brian Kennedy
Genes determining yeast replicative life span in a long-lived genetic background.
Mechanisms of ageing and development 2005;126(4):491-504.
2005: Erica D Smith; Brian A Kudlow; Richard L Frock; Brian Kennedy
A-type nuclear lamins, progerias and other degenerative disorders.
Mechanisms of ageing and development 2005;126(4):447-60.
2005: Shurong Huang; Brian Kennedy; Oshima Junko
LMNA mutations in progeroid syndromes.
Novartis Foundation symposium 2005;264():197-202; discussion 202-7, 227-30.
2005: Matt Kaeberlein; Brian Kennedy
Large-scale identification in yeast of conserved ageing genes.
Mechanisms of ageing and development 2005;126(1):17-21.
2004: Matt Kaeberlein; Kathryn T Kirkland; Stanley Fields; Brian Kennedy
Sir2-independent life span extension by calorie restriction in yeast.
PLoS biology 2004;2(9):E296.
2004: Brett Johnson; Ryan T Nitta; Richard L Frock; Leslie Mounkes; David A Barbie; Colin L Stewart; Ed Harlow; Brian Kennedy
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9677-82.
2004: David A Barbie; Brian A Kudlow; Richard L Frock; Jiyong Zhao; Brett Johnson; Nicholas J Dyson; Ed Harlow; Brian Kennedy
Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit.
Molecular and cellular biology 2004;24(2):595-607.
2003: Lishan Chen; Lin Lee; Brian A Kudlow; Heloisa G Dos Santos; Olav Sletvold; Yousef Shafeghati; Eleanor G Botha; Abhimanyu Garg; Nancy B Hanson; George M Martin; I Saira Mian; Brian Kennedy; Oshima Junko
LMNA mutations in atypical Werner's syndrome.
Lancet 2003;362(9382):440-5.
2002: Brian Kennedy
Mammalian transcription factors in yeast: strangers in a familiar land.
Nature reviews. Molecular cell biology 2002;3(1):41-9.
2001: Brian Kennedy; O W Liu; Frederick A Dick; Nicholas J Dyson; Ed Harlow; Marc Vidal
Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8720-5.
2001: A Lai; Brian Kennedy; David A Barbie; Nicholas Bertos; Xiang-Jiao Yang; M C Theberge; S C Tsai; Edward Seto; Yi Zhang; Andrei Kuzmichev; William Stratton Lane; Danny Reinberg; Ed Harlow; Philip E Branton
RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest.
Molecular and cellular biology 2001;21(8):2918-32.
2001: L F Stevenson; Brian Kennedy; Ed Harlow
A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3946-51.
2000: Brian Kennedy; David A Barbie; Marie Classon; Nicholas J Dyson; Ed Harlow
Nuclear organization of DNA replication in primary mammalian cells.
Genes & development 2000;14(22):2855-68.
2000: Marie Classon; Brian Kennedy; Roseann Mulloy; Ed Harlow
Opposing roles of pRB and p107 in adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10826-31.
2000: Jiyong Zhao; Brian Kennedy; B D Lawrence; David A Barbie; A G Matera; J A Fletcher; Ed Harlow
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
Genes & development 2000;14(18):2283-97.
2000: Katherine M Hannan; Brian Kennedy; Alice H Cavanaugh; Ross D Hannan; Iwona Hirschler-Laszkiewicz; Leonard S Jefferson; Lawrence Rothblum
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest.
Oncogene 2000;19(31):3487-97.
1997: Monica Gotta; S Strahl-Bolsinger; H Renauld; Thierry Laroche; Brian Kennedy; Michael Grunstein; Susan Gasser
Localization of Sir2p: the nucleolus as a compartment for silent information regulators.
The EMBO journal 1997;16(11):3243-55.
1997: Brian Kennedy; Monica Gotta; DA Sinclair; K Mills; DS McNabb; M Murthy; S M Pak; Thierry Laroche; Susan Gasser; Leonard Guarente
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
Cell 1997;89(3):381-91.
1996: Brian Kennedy; L Guarente
Genetic analysis of aging in Saccharomyces cerevisiae.
Trends in genetics : TIG 1996;12(9):355-9.
1995: Brian Kennedy; N R Austriaco; J Zhang; Leonard Guarente
Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
Cell 1995;80(3):485-96.
1994: Brian Kennedy; N R Austriaco; Leonard Guarente
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span.
The Journal of cell biology 1994;127(6 Pt 2):1985-93.
1989: Richard F Gaber; D M Copple; Brian Kennedy; Marc Vidal; M Bard
The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol.
Molecular and cellular biology 1989;9(8):3447-56.