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John Hancock

Research Profile

Phenomena

Evolution, Molecular

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Mouse

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Chemicals & Drugs

Genes & Molecular Sequences

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Publications

TOP 3
Paul N Schofield; John Hancock
Integration of global resources for human genetic variation and disease.
Octavio Espinosa; John Hancock
A gene-phenotype network for the laboratory mouse and its implications for systematic phenotyping.
Chrysanthi Ainali; Octavio Espinosa; Shiri Freilich; Lee Hazelwood; Christos Ouzounis; Michelle Simon; Sophia Tsoka; John Hancock
Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins.

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All Publications

2012: Paul N Schofield; John Hancock
Integration of global resources for human genetic variation and disease.
Human mutation 2012;33(5):813-6.
2011: Octavio Espinosa; John Hancock
A gene-phenotype network for the laboratory mouse and its implications for systematic phenotyping.
PloS one 2011;6(5):e19693.
2011: Chrysanthi Ainali; Octavio Espinosa; Shiri Freilich; Lee Hazelwood; Christos Ouzounis; Michelle Simon; Sophia Tsoka; John Hancock
Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins.
BMC evolutionary biology 2011;11():142.
2010: Damian Smedley; Paul Schofield; Chao-Kung Chen; Vassilis Aidinis; Chrysanthi Ainali; Jonathan Bard; Rudi Balling; Ewan Birney; Andrew Blake; Erik Bongcam-rudloff; Anthony J Brookes; Gianni Cesareni; Christina Chandras; Janan Eppig; Paul Flicek; Georgios Gkoutos; Simon Greenaway; Michael Gruenberger; Jean-Karim Hériché; Andrew Lyall; Ann-Marie Mallon; Dawn Muddyman; Florian Reisinger; Martin Ringwald; Nadia Rosenthal; Klaus Schughart; Morris Swertz; Gudmundur A Thorisson; Michael Zouberakis; John Hancock
Finding and sharing: new approaches to registries of databases and services for the biomedical sciences.
Database : the journal of biological databases and curation 2010;2010():baq014.
2010: Michael Zouberakis; Christina Chandras; Morris Swertz; Damian Smedley; Michael Gruenberger; Jonathan Bard; Klaus Schughart; Nadia Rosenthal; John Hancock; Paul N Schofield; George Kollias; Vassilis Aidinis
Mouse Resource Browser--a database of mouse databases.
Database : the journal of biological databases and curation 2010;2010():baq010.
2009: Paul N Schofield; Tania Bubela; Thomas Weaver; Lili Portilla; Stephen D Brown; John Hancock; David Einhorn; Glauco Tocchini-Valentini; Martin Hrabe de Angelis; Nadia Rosenthal
Post-publication sharing of data and tools.
Nature 2009;461(7261):171-3.
2009: Steve D M Brown; Wolfgang Wurst; Ralf Kühn; John Hancock
The functional annotation of mammalian genomes: the challenge of phenotyping.
Annual review of genetics 2009;43():305-33.
2009: Michelle Simon; John Hancock
Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins.
Genome biology 2009;10(6):R59.
2008: Damian Smedley; Morris A Swertz; Katy Wolstencroft; Glenn Proctor; Michael Zouberakis; Jonathan Bard; John Hancock; Paul Schofield
Solutions for data integration in functional genomics: a critical assessment and case study.
Briefings in bioinformatics 2008;9(6):532-44.
2008: Ann-Marie Mallon; Andrew Blake; John Hancock
EuroPhenome and EMPReSS: online mouse phenotyping resource.
Nucleic acids research 2008;36(Database issue):D715-8.
2007: John Hancock; Ann-Marie Mallon
Phenobabelomics--mouse phenotype data resources.
Briefings in functional genomics & proteomics 2007;6(4):292-301.
2007: Eli Reuveni; Valeria Carola; Mumna Banchaabouchi; Nadia Rosenthal; John Hancock; Cornelius Gross
Phenostat: visualization and statistical tool for analysis of phenotyping data.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(9):677-81.
2007: Nan Jiang; Roger D Cox; John Hancock
A kinetic core model of the glucose-stimulated insulin secretion network of pancreatic beta cells.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(6-7):508-20.
2007: John Hancock; Niels Adams; Vassilis Aidinis; Andrew Blake; Molly Bogue; Steve D M Brown; Elissa J Chesler; Duncan Davidson; Christopher Duran; Janan T Eppig; Valérie Gailus-Durner; Hilary Gates; Georgios V Gkoutos; Simon Greenaway; Martin Hrabé de Angelis; Werner Muller; Sophie Leblanc; Kirsty Lee; Christoph Lengger; Holger Maier; Ann-Marie Mallon; Hiroshi Masuya; David G Melvin; Werner Müller; Helen Parkinson; Glenn Proctor; Eli Reuveni; Paul Schofield; Aadya Shukla; Cynthia Smith; Tetsuro Toyoda; Laurent Vasseur; Shigeharu Wakana; Alison Walling; Jacqui White; Joe Wood; Michalis Zouberakis
Mouse Phenotype Database Integration Consortium: integration [corrected] of mouse phenome data resources.
Mammalian genome : official journal of the International Mammalian Genome Society 2007;18(3):157-63.
2006: Steve D M Brown; John Hancock; Hilary Gates
Understanding mammalian genetic systems: the challenge of phenotyping in the mouse.
PLoS genetics 2006;2(8):e118.
2005: John Hancock
Gene factories, microfunctionalization and the evolution of gene families.
Trends in genetics : TIG 2005;21(11):591-5.
2005: Eain C J Green; Georgios V Gkoutos; Heena V Lad; Andrew Blake; Joseph Weekes; John Hancock
EMPReSS: European mouse phenotyping resource for standardized screens.
Bioinformatics (Oxford, England) 2005;21(12):2930-1.
2005: Georgios V Gkoutos; Eain C J Green; Simon Greenaway; Andrew Blake; Ann-Marie Mallon; John Hancock
CRAVE: a database, middleware and visualization system for phenotype ontologies.
Bioinformatics (Oxford, England) 2005;21(7):1257-62.
2005: John Hancock; Michelle Simon
Simple sequence repeats in proteins and their significance for network evolution.
Gene 2005;345(1):113-8.
2005: Georgios V Gkoutos; Eain C J Green; Ann-Marie Mallon; John Hancock; Duncan Davidson
Using ontologies to describe mouse phenotypes.
Genome biology 2005;6(1):R8.
2004: John Hancock
A bigger mouse? The rat genome unveiled.
BioEssays : news and reviews in molecular, cellular and developmental biology 2004;26(10):1039-42.
2004: Ann-Marie Mallon; Laurens G Wilming; Joseph Weekes; James G R Gilbert; Jennifer L Ashurst; Sandrine Peyrefitte; Lucy Matthews; Matthew Cadman; Richard McKeone; Chris A Sellick; Ruth Arkell; Marc R M Botcherby; Mark A Strivens; R Duncan Campbell; Simon Gregory; Paul Denny; John Hancock; Jane Rogers; Steve D M Brown
Organization and evolution of a gene-rich region of the mouse genome: a 12.7-Mb region deleted in the Del(13)Svea36H mouse.
Genome research 2004;14(10A):1888-901.
2004: Georgios V Gkoutos; E C J Green; Ann-Marie Mallon; John Hancock; D Davidson
Building mouse phenotype ontologies.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2004;():178-89.
2003: Mauro F Santibáñez-Koref; R Gangeswaran; I P Santibáñez Koref; N Shanahan; John Hancock
A phylogenetic approach to assessing the significance of missense mutations in disease genes.
Human mutation 2003;22(1):51-8.
2003: Ilham Shahmuradov; Alex J Gammerman; John Hancock; Peter M Bramley; Victor V Solovyev
PlantProm: a database of plant promoter sequences.
Nucleic acids research 2003;31(1):114-7.
2002: John Hancock
Genome size and the accumulation of simple sequence repeats: implications of new data from genome sequencing projects.
Genetica 2002;115(1):93-103.
2002: M Mar Albà; Roman A Laskowski; John Hancock
Detecting cryptically simple protein sequences using the SIMPLE algorithm.
Bioinformatics (Oxford, England) 2002;18(5):672-8.
2001: Alistair P McGregor; Philip J Shaw; John Hancock; Daniel Bopp; Monika Hediger; Naomi S Wratten; Gabriel A Dover
Rapid restructuring of bicoid-dependent hunchback promoters within and between Dipteran species: implications for molecular coevolution.
Evolution & development 2001;3(6):397-407.
2001: Mauro F Santibáñez-Koref; R Gangeswaran; John Hancock
A relationship between lengths of microsatellites and nearby substitution rates in mammalian genomes.
Molecular biology and evolution 2001;18(11):2119-23.
2001: John Hancock; E A Worthey; Mauro F Santibáñez-Koref
A role for selection in regulating the evolutionary emergence of disease-causing and other coding CAG repeats in humans and mice.
Molecular biology and evolution 2001;18(6):1014-23.
2001: JH von der Schulenburg; John Hancock; A Pagnamenta; J J Sloggett; Michael E N Majerus; Gregory D D Hurst
Extreme length and length variation in the first ribosomal internal transcribed spacer of ladybird beetles (Coleoptera: Coccinellidae).
Molecular biology and evolution 2001;18(4):648-60.
2001: M Mar Albà; Mauro F Santibáñez-Koref; John Hancock
The comparative genomics of polyglutamine repeats: extreme differences in the codon organization of repeat-encoding regions between mammals and Drosophila.
Journal of molecular evolution 2001;52(3):249-59.
2000: John Hancock; Alfried P Vogler
How slippage-derived sequences are incorporated into rRNA variable-region secondary structure: implications for phylogeny reconstruction.
Molecular phylogenetics and evolution 2000;14(3):366-74.
1999: CP Choe; John Hancock; UW Hwang; W Kim
Analysis of the primary sequence and secondary structure of the unusually long SSU rRNA of the soil bug, Armadillidium vulgare.
Journal of molecular evolution 1999;49(6):798-805.
1999: M Mar Albà; Mauro F Santibáñez-Koref; John Hancock
Amino acid reiterations in yeast are overrepresented in particular classes of proteins and show evidence of a slippage-like mutational process.
Journal of molecular evolution 1999;49(6):789-97.
1999: M Mar Albà; Mauro F Santibáñez-Koref; John Hancock
Conservation of polyglutamine tract size between mice and humans depends on codon interruption.
Molecular biology and evolution 1999;16(11):1641-4.
1999: John Hancock; Philip J Shaw; F Bonneton; Gabriel A Dover
High sequence turnover in the regulatory regions of the developmental gene hunchback in insects.
Molecular biology and evolution 1999;16(2):253-65.
1999: P Bradbury; Christopher J Mann; S Köchl; Timothy A Anderson; S A Chester; John Hancock; PJ Ritchie; Joanna Amey; G B Harrison; David G Levitt; Leonard J Banaszak; James Scott; Carol C Shoulders
A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase.
The Journal of biological chemistry 1999;274(5):3159-64.
1999: Christopher J Mann; Timothy A Anderson; J Read; S A Chester; G B Harrison; S Köchl; PJ Ritchie; P Bradbury; F S Hussain; Joanna Amey; Berlinda Vanloo; Maryvonne Rosseneu; R Infante; John Hancock; David G Levitt; Leonard J Banaszak; James Scott; Carol C Shoulders
The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins.
Journal of molecular biology 1999;285(1):391-408.
1998: John Hancock; Mauro F Santibáñez-Koref
Trinucleotide expansion diseases in the context of micro- and minisatellite evolution, Hammersmith Hospital, April 1-3, 1998.
The EMBO journal 1998;17(19):5521-4.
1998: John Hancock; Alfried P Vogler
Modelling the secondary structures of slippage-prone hypervariable RNA regions: the example of the tiger beetle 18S rRNA variable region V4.
Nucleic acids research 1998;26(7):1689-99.
1997: Alfried P Vogler; A Welsh; John Hancock
Phylogenetic analysis of slippage-like sequence variation in the V4 rRNA expansion segment in tiger beetles (Cicindelidae).
Molecular biology and evolution 1997;14(1):6-19.
1996: John Hancock
Simple sequences in a "minimal' genome.
Nature genetics 1996;14(1):14-5.
1996: John Hancock
Simple sequences and the expanding genome.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(5):421-5.
1996: J Rohozinski; John Hancock
Do light-induced pH changes within the chloroplast drive turnip yellow mosaic virus assembly?
The Journal of general virology 1996;77 ( Pt 2 )():163-5.
1996: Philippe Djian; John Hancock; Harjinder Chana
Codon repeats in genes associated with human diseases: fewer repeats in the genes of nonhuman primates and nucleotide substitutions concentrated at the sites of reiteration.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):417-21.
1995: John Hancock; W Chaleeprom; W Chaleeprom; J Dale; A Gibbs
Replication slippage in the evolution of potyviruses.
The Journal of general virology 1995;76 ( Pt 12)():3229-32.
1995: John Hancock
The contribution of slippage-like processes to genome evolution.
Journal of molecular evolution 1995;41(6):1038-47.
1995: John Hancock
The contribution of DNA slippage to eukaryotic nuclear 18S rRNA evolution.
Journal of molecular evolution 1995;40(6):629-39.
1994: J Rohozinski; John Hancock; Max A Keniry
Polycytosine regions contained in DNA hairpin loops interact via a four-stranded, parallel structure similar to the i-motif.
Nucleic acids research 1994;22(22):4653-9.
1994: John Hancock; J S Armstrong
SIMPLE34: an improved and enhanced implementation for VAX and Sun computers of the SIMPLE algorithm for analysis of clustered repetitive motifs in nucleotide sequences.
Computer applications in the biosciences : CABIOS 1994;10(1):67-70.
1993: A R Hoelzel; John Hancock; Gabriel A Dover
Generation of VNTRs and heteroplasmy by sequence turnover in the mitochondrial control region of two elephant seal species.
Journal of molecular evolution 1993;37(2):190-7.
1993: John Hancock
Evolution of sequence repetition and gene duplications in the TATA-binding protein TBP (TFIID).
Nucleic acids research 1993;21(12):2823-30.
1993: Gabriel A Dover; A R Linares; T Bowen; John Hancock
Detection and quantification of concerted evolution and molecular drive.
Methods in enzymology 1993;224():525-41.
1991: A R Hoelzel; John Hancock; Gabriel A Dover
Evolution of the cetacean mitochondrial D-loop region.
Molecular biology and evolution 1991;8(4):475-93.
1991: A Ruiz Linares; John Hancock; Gabriel A Dover
Secondary structure constraints on the evolution of Drosophila 28 S ribosomal RNA expansion segments.
Journal of molecular biology 1991;219(3):381-90.
1990: John Hancock; Gabriel A Dover
'Compensatory slippage' in the evolution of ribosomal RNA genes.
Nucleic acids research 1990;18(20):5949-54.
1988: John Hancock; Gabriel A Dover
Molecular coevolution among cryptically simple expansion segments of eukaryotic 26S/28S rRNAs.
Molecular biology and evolution 1988;5(4):377-91.
1988: John Hancock; D Tautz; Gabriel A Dover
Evolution of the secondary structures and compensatory mutations of the ribosomal RNAs of Drosophila melanogaster.
Molecular biology and evolution 1988;5(4):393-414.
1988: D Tautz; John Hancock; D A Webb; C Tautz; Gabriel A Dover
Complete sequences of the rRNA genes of Drosophila melanogaster.
Molecular biology and evolution 1988;5(4):366-76.
1987: John Hancock; R G Burns
Specificity and biological significance of microtubule-associated protein-DNA interactions in chick.
Biochimica et biophysica acta 1987;927(2):163-9.
1982: John Hancock; A T Sumner
The role of proteins in the production of different types of chromosome bands.
Cytobios 1982;35(137):37-46.