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Erik Lubberts

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Ferry Cornelissen; Odilia Corneth; Kristine Kikly; Patrick S Asmawidjaja; Adriana M C Mus; Erik Lubberts
IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritis.
Jan Piet Van Hamburg; Johannes P T M van Leeuwen; Adriana M C Mus; Patrick S Asmawidjaja; Pieter A G M Bakx; Edgar M Colin; Ferry Cornelissen; Nadine Davelaar; R J E M Dolhain; J M W Hazes; Erik Lubberts
TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation.
Maarten J C Leijs; Erik Lubberts; Gerben M van Buul; Pieter K Bos; Martin J Hoogduijn; Jan A N Verhaar; Gerjo J V M van Osch
Effect of Arthritic Synovial Fluids on the Expression of Immunomodulatory Factors by Mesenchymal Stem Cells: An Explorative in vitro Study.

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2013: Ferry Cornelissen; Odilia Corneth; Kristine Kikly; Patrick S Asmawidjaja; Adriana M C Mus; Erik Lubberts
IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritis.
PloS one 2013;8(2):e57553.
2012: Jan Piet Van Hamburg; Johannes P T M van Leeuwen; Adriana M C Mus; Patrick S Asmawidjaja; Pieter A G M Bakx; Edgar M Colin; Ferry Cornelissen; Nadine Davelaar; R J E M Dolhain; J M W Hazes; Erik Lubberts
TNF blockade requires 1,25(OH)2D3 to control human Th17-mediated synovial inflammation.
Annals of the rheumatic diseases 2012;71(4):606-12.
2012: Maarten J C Leijs; Erik Lubberts; Gerben M van Buul; Pieter K Bos; Martin J Hoogduijn; Jan A N Verhaar; Gerjo J V M van Osch
Effect of Arthritic Synovial Fluids on the Expression of Immunomodulatory Factors by Mesenchymal Stem Cells: An Explorative in vitro Study.
Frontiers in immunology 2012;3():231.
2011: Peter I Boross; Marina Botto; Cor Breukel; Marcel Camps; Francesco Carlucci; Jill W C Claassens; H Terence Cook; Mohamed R Daha; Roelof Flierman; Shozo Izui; Erik Lubberts; Javier Martin-Ramirez; Ferry Ossendorp; Maria Pia Rastaldi; Daniela Salvatori; Marie-Laure Santiago-Raber; Jos van der Kaa; Victoria L Arandhara; Sjef Verbeek
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1304-13.
2011: Tom M Piscaer; Roger Schibli; Jan A N Verhaar; Marjon De Jong; Eric P Krenning; Erik Lubberts; Thomas L Mindt; Cristina Müller; Harrie Weinans
Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography.
Arthritis and rheumatism 2011;63(7):1898-907.
2011: Jan Piet Van Hamburg; P S Asmawidjaja; N Davelaar; A M C Mus; Edgar M Colin; J M W Hazes; R J E M Dolhain; Erik Lubberts
Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.
Arthritis and rheumatism 2011;63(1):73-83.
2010: Adriana M C Mus; Ferry Cornelissen; Patrick S Asmawidjaja; Jan Piet Van Hamburg; Louis Boon; Rudolf W Hendriks; Erik Lubberts
Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis.
Arthritis and rheumatism 2010;62(4):1043-50.
2010: Erik Lubberts
Th17 cytokines and arthritis.
Seminars in immunopathology 2010;32(1):43-53.
2010: Jolanda J Luime; Edgar M Colin; J M W Hazes; Erik Lubberts
Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review.
Annals of the rheumatic diseases 2010;69(2):337-44.
2010: Myew-Ling Toh; Gaelle Gonzales; Marije I Koenders; Anne Tournadre; David Boyle; Erik Lubberts; Yuan Zhou; Gary S Firestein; Wim B van den Berg; Pierre Miossec
Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression.
PloS one 2010;5(10):e13416.
2010: Edgar M Colin; P S Asmawidjaja; Jan Piet Van Hamburg; A M C Mus; M van Driel; J M W Hazes; Johannes P T M van Leeuwen; Erik Lubberts
1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis.
Arthritis and rheumatism 2010;62(1):132-42.
2009: Mark Wenink; Kim C M Santegoets; Jacobus C A Broen; Lenny van Bon; Shahla Abdollahi-Roodsaz; Calin Popa; Richard Huijbens; Thijs Remijn; Erik Lubberts; Piet L C M van Riel; Wim B van den Berg; Timothy R D J Radstake
TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):6960-70.
2009: Ferry Cornelissen; Jan P van Hamburg; Erik Lubberts
The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis.
Current opinion in investigational drugs (London, England : 2000) 2009;10(5):452-62.
2009: Leslie van der Fits; Sabine Mourits; Jane S A Voerman; Marius Kant; Louis Boon; Jon D Laman; Ferry Cornelissen; Anne-Marie Mus; Edwin Florencia; Errol P Prens; Erik Lubberts
Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5836-45.
2009: Jan Piet Van Hamburg; Anne-Marie Mus; Marjolein J W de Bruijn; Lisette de Vogel; Louis Boon; Ferry Cornelissen; Patrick Asmawidjaja; Rudolf W Hendriks; Erik Lubberts
GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis.
Arthritis and rheumatism 2009;60(3):750-9.
2009: Ferry Cornelissen; Adriana Mc Mus; Patrick S Asmawidjaja; Jan Piet Van Hamburg; Joel Tocker; Erik Lubberts
Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cells.
Arthritis research & therapy 2009;11(6):R194.
2009: Timothy R D J Radstake; Lenny van Bon; Jasper Broen; Anila Hussiani; Roger Hesselstrand; Dirk M Wuttge; Yanhui Deng; Robbert Simms; Erik Lubberts; Robert Lafyatis
The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.
PloS one 2009;4(6):e5903.
2008: Nozomi Takahashi; Ineke Vanlaere; Riet De Rycke; Anje Cauwels; Leo A B Joosten; Erik Lubberts; Wim B van den Berg; Claude Libert
IL-17 produced by Paneth cells drives TNF-induced shock.
The Journal of experimental medicine 2008;205(8):1755-61.
2008: Erik Lubberts
IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?
Cytokine 2008;41(2):84-91.
2006: P L E M van Lent; Lilyanne Grevers; Erik Lubberts; Teun J de Vries; K C A M Nabbe; Sjef Verbeek; Birgit Oppers; Annet Sloetjes; Arjen B Blom; Wim B van den Berg
Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation.
Arthritis and rheumatism 2006;54(12):3868-77.
2006: Marije I Koenders; Erik Lubberts; Fons A J van de Loo; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Jay K Kolls; Franco E Di Padova; Leo A B Joosten; Wim B van den Berg
Interleukin-17 acts independently of TNF-alpha under arthritic conditions.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6262-9.
2005: Marije I Koenders; Jay K Kolls; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Leo A B Joosten; Jill R Schurr; Paul Schwarzenberger; Wim B van den Berg; Erik Lubberts
Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.
Arthritis and rheumatism 2005;52(10):3239-47.
2005: Erik Lubberts; Paul Schwarzenberger; Weitao Huang; Jill R Schurr; Jacques J Peschon; Wim B van den Berg; Jay K Kolls
Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3360-8.
2005: Marije I Koenders; Erik Lubberts; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Franco E Di Padova; Mieke Boots; Hermann Gram; Leo A B Joosten; Wim B van den Berg
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.
The American journal of pathology 2005;167(1):141-9.
2005: Marije I Koenders; Erik Lubberts; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Monique M A Helsen; Jay K Kolls; Leo A B Joosten; Wim B van den Berg
Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1.
Arthritis and rheumatism 2005;52(3):975-83.
2005: Erik Lubberts; Marije I Koenders; Wim B van den Berg
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models.
Arthritis research & therapy 2005;7(1):29-37.
2004: Leo A B Joosten; Ruben L Smeets; Marije I Koenders; Liduine Van Den Bersselaar; Monique M A Helsen; Birgitte Oppers-Walgreen; Erik Lubberts; Yoichiro Iwakura; Fons A J van de Loo; Wim B van den Berg
Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction.
The American journal of pathology 2004;165(3):959-67.
2004: Erik Lubberts; Marije I Koenders; Birgitte Oppers-Walgreen; Liduine Van Den Bersselaar; Christina J J Coenen-de Roo; Leo A B Joosten; Wim B van den Berg
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion.
Arthritis and rheumatism 2004;50(2):650-9.
2003: Maaike Everts; Sigridur A Asgeirsdóttir; Robbert J Kok; J Twisk; B de Vries; Erik Lubberts; Erwin J Bos; N Werner; D K F Mejer; Grietje Molema
Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(12):512-8.
2003: Leo A B Joosten; Marije I Koenders; Ruben L Smeets; Marleen Heuvelmans-Jacobs; Monique M A Helsen; Kiyoshi Takeda; Shizuo Akira; Erik Lubberts; Fons A J van de Loo; Wim B van den Berg
Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):6145-53.
2003: Fons A J van de Loo; Miranda B Bennink; Onno J Arntz; Ruben L Smeets; Erik Lubberts; Leo A B Joosten; P L E M van Lent; Christina J J Coenen-de Roo; Salvatore Cuzzocrea; Brahm H Segal; Steven M Holland; Wim B van den Berg
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
The American journal of pathology 2003;163(4):1525-37.
2003: Erik Lubberts
The role of IL-17 and family members in the pathogenesis of arthritis.
Current opinion in investigational drugs (London, England : 2000) 2003;4(5):572-7.
2003: Erik Lubberts; Liduine Van Den Bersselaar; Birgitte Oppers-Walgreen; Paul Schwarzenberger; Christina J J Coenen-de Roo; Jay K Kolls; Leo A B Joosten; Wim B van den Berg
IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2655-62.
2003: Leo A B Joosten; Timothy Radstake; Erik Lubberts; Liduine Van Den Bersselaar; P L C M van Riel; P L E M van Lent; Pilar Barrera; Wim B van den Berg
Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis.
Arthritis and rheumatism 2003;48(2):339-47.
2003: Erik Lubberts; Wim B van den Berg
Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis.
Advances in experimental medicine and biology 2003;520():194-202.
2002: Erik Lubberts; Birgitte Oppers-Walgreen; Allison R Pettit; Liduine Van Den Bersselaar; Leo A B Joosten; Steven R Goldring; Ellen M Gravallese; Wim B van den Berg
Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis.
Arthritis and rheumatism 2002;46(11):3055-64.
2002: Leo A B Joosten; Marleen Heuvelmans-Jacobs; Erik Lubberts; Fons A J van de Loo; Andrew C Bakker; Monique M A Helsen; Carl D Richards; Wim B van den Berg
Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis.
Arthritis and rheumatism 2002;46(5):1379-89.
2002: Alfons S K de Hooge; Fons A J van de Loo; Miranda B Bennink; Dick S de Jong; Onno J Arntz; Erik Lubberts; Carl D Richards; Wim B vandDen Berg
Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligand.
The American journal of pathology 2002;160(5):1733-43.
2002: P L E M van Lent; A E M Holthuysen; Annet W Slöetjes; Erik Lubberts; Wim B van den Berg
Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2002;10(3):234-43.
2002: Erik Lubberts; Leo A B Joosten; Fons A J van de Loo; Paul Schwarzenberger; J Kolls; W B van den Berg
Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(2):102-4.
2001: Christine Plater-Zyberk; Leo A B Joosten; Monique M A Helsen; P Sattonnet-Roche; C Siegfried; Sami Alouani; Fons A J van de Loo; Pierre Graber; S Aloni; Rocco Cirillo; Erik Lubberts; Charles A Dinarello; Wim B van den Berg; Yolande Chvatchko
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis.
The Journal of clinical investigation 2001;108(12):1825-32.
2001: Erik Lubberts; W B van den Berg
Potential of modulatory cytokines in the rheumatoid arthritis process.
Drug news & perspectives 2001;14(9):517-22.
2001: Erik Lubberts; Leo A B Joosten; Birgit Oppers; Liduine Van Den Bersselaar; Christina J J Coenen-de Roo; Jay K Kolls; Paul Schwarzenberger; Fons A J van de Loo; Wim B van den Berg
IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):1004-13.
2001: Biserka Relic; Jérôme Guicheux; Françoise Mezin; Erik Lubberts; D Togninalli; IRENE GARCIA; W B van den Berg; Pierre-André Guerne
Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2775-82.
2001: M Chabaud; Erik Lubberts; Leo A B Joosten; Wim B van den Berg; Pierre Miossec
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis.
Arthritis research 2001;3(3):168-77.
2000: Leo A B Joosten; Fons A J van de Loo; Erik Lubberts; Monique M A Helsen; Mihai G Netea; Jos W M van der Meer; Charles A Dinarello; Wim B van den Berg
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6553-8.
2000: Wim B van den Berg; Leo A B Joosten; Erik Lubberts; Fons A J van de Loo; P L E M van Lent
Cytokine directed targeting in chronic arthritis.
European cytokine network 2000;11(3):481-2.
2000: Erik Lubberts; Leo A B Joosten; M Chabaud; Liduine Van Den Bersselaar; Birgit Oppers; Christina J J Coenen-de Roo; Carl D Richards; Pierre Miossec; Wim B van den Berg
IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.
The Journal of clinical investigation 2000;105(12):1697-710.
2000: Erik Lubberts; Leo A B Joosten; Fons A J van de Loo; L A van den Gersselaar; Wim B van den Berg
Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4.
Arthritis and rheumatism 2000;43(6):1300-6.
2000: Erik Lubberts; Leo A B Joosten; Liduine Van Den Bersselaar; Monique M A Helsen; Andrew C Bakker; Zhou Xing; Carl D Richards; Wim B van den Berg
Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw.
Clinical and experimental immunology 2000;120(2):375-83.
2000: Leo A B Joosten; Christina J J Coenen-de Roo; Monique M A Helsen; Erik Lubberts; Mieke Boots; Wim B van den Berg; André M M Miltenburg
Induction of tolerance with intranasal administration of human cartilage gp-39 in DBA/1 mice: amelioration of clinical, histologic, and radiologic signs of type II collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):645-55.
2000: W B van den Berg; Leo A B Joosten; Erik Lubberts
Cytokine-directed targeting in chronic arthritis.
Current directions in autoimmunity 2000;2():103-25.
1999: Erik Lubberts; Leo A B Joosten; Liduine Van Den Bersselaar; Monique M A Helsen; Andrew C Bakker; J B van Meurs; F L Graham; Carl D Richards; Wim B van den Berg
Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4546-56.
1999: Leo A B Joosten; Erik Lubberts; Monique M A Helsen; Tore Saxne; Christina J J Coenen-de Roo; D Heinegård; Wim B van den Berg
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.
Arthritis research 1999;1(1):81-91.
1998: Erik Lubberts; Leo A B Joosten; Monique M A Helsen; Wim B van den Berg
Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone.
Cytokine 1998;10(5):361-9.
1997: Leo A B Joosten; Erik Lubberts; Monique M A Helsen; Wim B van den Berg
Dual role of IL-12 in early and late stages of murine collagen type II arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(8):4094-102.
1997: Leo A B Joosten; Erik Lubberts; P Durez; Monique M A Helsen; M J Jacobs; M Goldman; Wim B van den Berg
Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis. Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction.
Arthritis and rheumatism 1997;40(2):249-60.