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Karim Echtay

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Publications

TOP 3
Takla G El-Khoury; Georges M Bahr; Karim S Echtay
Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species.
Karim S Echtay
Mitochondrial uncoupling proteins--what is their physiological role?
Karim S Echtay; Martin D Brand
4-hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production.

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All Publications

2011: Takla G El-Khoury; Georges M Bahr; Karim S Echtay
Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species.
The FEBS journal 2011;278(17):3054-64.
2007: Karim S Echtay
Mitochondrial uncoupling proteins--what is their physiological role?
Free radical biology & medicine 2007;43(10):1351-71.
2007: Karim S Echtay; Martin D Brand
4-hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production.
Redox report : communications in free radical research 2007;12(1):26-9.
2005: Karim S Echtay; Julian L Pakay; Telma C Esteves; Martin D Brand
Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage.
BioFactors (Oxford, England) 2005;24(1-4):119-30.
2004: Telma C Esteves; Karim S Echtay; Tanya Jonassen; Catherine F Clarke; Martin D Brand
Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria.
The Biochemical journal 2004;379(Pt 2):309-15.
2004: Martin D Brand; Julie A Buckingham; Telma C Esteves; Katherine Green; Adrian J Lambert; Satomi Miwa; Michael P Murphy; Julian L Pakay; Darren A Talbot; Karim S Echtay
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production.
Biochemical Society symposium 2004;(71):203-13.
2003: Michael P Murphy; Karim S Echtay; Frances H Blaikie; Jordi Asin-Cayuela; Helena M Cocheme; Katherine Green; Julie A Buckingham; Ellen R Taylor; Fiona Hurrell; Gillian Hughes; Satomi Miwa; Chris E Cooper; Dimitri A Svistunenko; Robin A J Smith; Martin D Brand
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
The Journal of biological chemistry 2003;278(49):48534-45.
2003: Mika B Jekabsons; Karim S Echtay; Ignacio Arechaga; Martin D Brand
Molecular properties of purified human uncoupling protein 2 refolded from bacterial inclusion bodies.
Journal of bioenergetics and biomembranes 2003;35(5):409-18.
2003: Karim S Echtay; Telma C Esteves; Julian L Pakay; Mika B Jekabsons; Adrian J Lambert; Manuel Portero-Otín; Reinald Pamplona; Antonio Vidal-Puig; Steven Wang; Stephen J Roebuck; Martin D Brand
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.
The EMBO journal 2003;22(16):4103-10.
2003: Michael J Considine; Megan Goodman; Karim S Echtay; Maryse Laloi; James Whelan; Martin D Brand; Lee J Sweetlove
Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein.
The Journal of biological chemistry 2003;278(25):22298-302.
2002: Karim S Echtay; Michael P Murphy; Robin A J Smith; Darren A Talbot; Martin D Brand
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants.
The Journal of biological chemistry 2002;277(49):47129-35.
2002: Mika B Jekabsons; Karim S Echtay; Martin D Brand
Nucleotide binding to human uncoupling protein-2 refolded from bacterial inclusion bodies.
The Biochemical journal 2002;366(Pt 2):565-71.
2002: Susana Cadenas; Karim S Echtay; James A Harper; Mika B Jekabsons; Julie A Buckingham; Evelyn Grau; Alejandro Abuin; Helen Chapman; John Clapham; Martin D Brand
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3.
The Journal of biological chemistry 2002;277(4):2773-8.
2002: Karim S Echtay; Damien Roussel; Julie St-Pierre; Mika B Jekabsons; Susana Cadenas; Jeff A Stuart; James A Harper; Stephen J Roebuck; Alastair Morrison; Susan Pickering; John Clapham; Martin D Brand
Superoxide activates mitochondrial uncoupling proteins.
Nature 2002;415(6867):96-9.
2001: Martin Klingenberg; Edith Winkler; Karim S Echtay
Uncoupling protein, H+ transport and regulation.
Biochemical Society transactions 2001;29(Pt 6):806-11.
2001: Karim S Echtay; Martin D Brand
Coenzyme Q induces GDP-sensitive proton conductance in kidney mitochondria.
Biochemical Society transactions 2001;29(Pt 6):763-8.
2001: Karim S Echtay; M Bienengraeber; Martin Klingenberg
Role of intrahelical arginine residues in functional properties of uncoupling protein (UCP1).
Biochemistry 2001;40(17):5243-8.
2001: Martin Klingenberg; Karim S Echtay
Uncoupling proteins: the issues from a biochemist point of view.
Biochimica et biophysica acta 2001;1504(1):128-43.
2001: Karim S Echtay; Edith Winkler; K Frischmuth; Martin Klingenberg
Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1416-21.
2000: Karim S Echtay; Edith Winkler; Martin Klingenberg
Coenzyme Q is an obligatory cofactor for uncoupling protein function.
Nature 2000;408(6812):609-13.
2000: Karim S Echtay; Edith Winkler; M Bienengraeber; Martin Klingenberg
Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions.
Biochemistry 2000;39(12):3311-7.
1999: Martin Klingenberg; Karim S Echtay; M Bienengraeber; Edith Winkler; Shu-Gui Huang
Structure-function relationship in UCP1.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23 Suppl 6():S24-9.
1999: Karim S Echtay; Q Liu; T Caskey; Edith Winkler; K Frischmuth; M Bienengräber; Martin Klingenberg
Regulation of UCP3 by nucleotides is different from regulation of UCP1.
FEBS letters 1999;450(1-2):8-12.
1998: Karim S Echtay; M Bienengraeber; Edith Winkler; Martin Klingenberg
In the uncoupling protein (UCP-1) His-214 is involved in the regulation of purine nucleoside triphosphate but not diphosphate binding.
The Journal of biological chemistry 1998;273(38):24368-74.
1998: M Bienengraeber; Karim S Echtay; Martin Klingenberg
H+ transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3.
Biochemistry 1998;37(1):3-8.
1997: Karim S Echtay; M Bienengraeber; Martin Klingenberg
Mutagenesis of the uncoupling protein of brown adipose tissue. Neutralization Of E190 largely abolishes pH control of nucleotide binding.
Biochemistry 1997;36(27):8253-60.