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Hennie Hoogenboom

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Chemicals & Drugs

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Saskia J A M Santegoets; Marco W J Schreurs; Anneke W Reurs; Jelle J Lindenberg; Esther W M Kueter; Alfons J M van den Eertwegh; Erik Hooijberg; Ricardo J M G E Brandwijk; Simon E Hufton; Hennie Hoogenboom; Rik J Scheper; Veerle A Somers; Tanja D de Gruijl
Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.
Gerhard Held; Andreas Wadle; Nina Dauth; Guillaume Stewart-Jones; Christine Sturm; Markus Thiel; Carsten Zwick; Detlef Dieckmann; Gerold Schuler; Hennie Hoogenboom; Frédéric Lévy; Vincenzo Cerundolo; Michael Pfreundschuh; Christoph Renner
MHC-peptide-specific antibodies reveal inefficient presentation of an HLA-A*0201-restricted, Melan-A-derived peptide after active intracellular processing.
Hennie Hoogenboom
Selecting and screening recombinant antibody libraries.

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All Publications

2007: Saskia J A M Santegoets; Marco W J Schreurs; Anneke W Reurs; Jelle J Lindenberg; Esther W M Kueter; Alfons J M van den Eertwegh; Erik Hooijberg; Ricardo J M G E Brandwijk; Simon E Hufton; Hennie Hoogenboom; Rik J Scheper; Veerle A Somers; Tanja D de Gruijl
Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):2005-12.
2007: Gerhard Held; Andreas Wadle; Nina Dauth; Guillaume Stewart-Jones; Christine Sturm; Markus Thiel; Carsten Zwick; Detlef Dieckmann; Gerold Schuler; Hennie Hoogenboom; Frédéric Lévy; Vincenzo Cerundolo; Michael Pfreundschuh; Christoph Renner
MHC-peptide-specific antibodies reveal inefficient presentation of an HLA-A*0201-restricted, Melan-A-derived peptide after active intracellular processing.
European journal of immunology 2007;37(7):2008-17.
2005: Hennie Hoogenboom
Selecting and screening recombinant antibody libraries.
Nature biotechnology 2005;23(9):1105-16.
2005: Detlef Dieckmann; Erwin S Schultz; Bernhard Ring; Patrick Chames; Gerhard Held; Hennie Hoogenboom; Gerold Schuler
Optimizing the exogenous antigen loading of monocyte-derived dendritic cells.
International immunology 2005;17(5):621-35.
2005: René Michael Hoet; Edward H Cohen; Rachel Baribault Kent; Kristin Rookey; Sonia Schoonbroodt; Shannon Hogan; Louise Rem; Nicolas Frans; Marc Daukandt; Henk Pieters; Rob van Hegelsom; Nicole Coolen-van Neer; Horacio G Nastri; Isaac J Rondon; Jennifer A Leeds; Simon E Hufton; Lili Huang; Irina Kashin; Mary Devlin; Guannan Kuang; Mieke Steukers; Malini Viswanathan; Andrew E Nixon; Daniel Sexton; Hennie Hoogenboom; Robert C Ladner
Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.
Nature biotechnology 2005;23(3):344-8.
2005: Martin Hülsmeyer; Patrick Chames; Roman C Hillig; Robyn L Stanfield; Gerhard Held; Pierre G Coulie; Claudia Alings; Gabriele Wille; Wolfram Saenger; Barbara Uchanska-Ziegler; Hennie Hoogenboom; Andreas Ziegler
A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3.
The Journal of biological chemistry 2005;280(4):2972-80.
2005: Sonia Schoonbroodt; Nicolas Frans; Mark DeSouza; Rachel Eren; Smadar Priel; Naama Brosh; Judith Ben-Porath; Arie Zauberman; Ehud Ilan; Shlomo Dagan; Edward H Cohen; Hennie Hoogenboom; Robert C Ladner; René M Hoet
Oligonucleotide-assisted cleavage and ligation: a novel directional DNA cloning technology to capture cDNAs. Application in the construction of a human immune antibody phage-display library.
Nucleic acids research 2005;33(9):e81.
2004: Lydia Blaise; Anita Wehnert; Mieke Steukers; Twan van den Beucken; Hennie Hoogenboom; Simon E Hufton
Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments.
Gene 2004;342(2):211-8.
2004: Gerhard Held; Mitsutoshi Matsuo; Malka Epel; Sacha Gnjatic; Gerd Ritter; Sang-Yull Lee; Tsin Yee Tai; Cyrille Cohen; Lloyd J Old; Michael Pfreundschuh; Yoram Reiter; Hennie Hoogenboom; Christoph Renner
Dissecting cytotoxic T cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragments.
European journal of immunology 2004;34(10):2919-29.
2004: Christelle Souriau; Julie Rothacker; Hennie Hoogenboom; Edouard C Nice
Human antibody fragments specific for the epidermal growth factor receptor selected from large non-immunised phage display libraries.
Growth factors (Chur, Switzerland) 2004;22(3):185-94.
2004: Thomas Jostock; Marc Vanhove; Eddy Brepoels; Reinoud Van Gool; Marc Daukandt; Anita Wehnert; Rob Van Hegelsom; Daniel T Dransfield; Dan Sexton; Mary Devlin; Art Ley; Hennie Hoogenboom; Jürgen Müllberg
Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries.
Journal of immunological methods 2004;289(1-2):65-80.
2004: Ricardo Mutuberria; Sietske Satijn; Angelique Huijbers; Edith Van Der Linden; Hera Lichtenbeld; Patrick Chames; Jan-Willem Arends; Hennie Hoogenboom
Isolation of human antibodies to tumor-associated endothelial cell markers by in vitro human endothelial cell selection with phage display libraries.
Journal of immunological methods 2004;287(1-2):31-47.
2003: Twan van den Beucken; Henk Pieters; Mieke Steukers; Marcel van der Vaart; Robert C Ladner; Hennie Hoogenboom; Simon E Hufton
Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries.
FEBS letters 2003;546(2-3):288-94.
2002: Cyrille Cohen; Noa Hoffmann; Marganit Farago; Hennie Hoogenboom; Lea Eisenbach; Yoram Reiter
Direct detection and quantitation of a distinct T-cell epitope derived from tumor-specific epithelial cell-associated mucin using human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells.
Cancer research 2002;62(20):5835-44.
2002: Judy van Beijnum; Peter Moerkerk; Andrea J Gerbers; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom; Simon E Hufton
Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer.
International journal of cancer. Journal international du cancer 2002;101(2):118-27.
2002: Veerle A Somers; Ricardo J M G E Brandwijk; Ben Joosten; Peter Moerkerk; Jan-Willem Arends; Paul P C A Menheere; Wendy O Pieterse; Anke Claessen; Rik J Scheper; Hennie Hoogenboom; Simon E Hufton
A panel of candidate tumor antigens in colorectal cancer revealed by the serological selection of a phage displayed cDNA expression library.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2772-80.
2002: Patrick Chames; Ralph A Willemsen; gertrudis rojas; Detlef Dieckmann; Louise Rem; Gerold Schuler; Reinder L H Bolhuis; Hennie Hoogenboom
TCR-like human antibodies expressed on human CTLs mediate antibody affinity-dependent cytolytic activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):1110-8.
2002: Galit Denkberg; Cyrille Cohen; Avital Lev; Patrick Chames; Hennie Hoogenboom; Yoram Reiter
Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9421-6.
2002: Avital Lev; Galit Denkberg; Cyrille Cohen; Maty Tzukerman; Karl Skorecki; Patrick Chames; Hennie Hoogenboom; Yoram Reiter
Isolation and characterization of human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells directed toward the widely expressed tumor T-cell epitopes of the telomerase catalytic subunit.
Cancer research 2002;62(11):3184-94.
2002: Paula Maria Henderikx; Nicole Coolen-van Neer; Anita Jacobs; Edith Van Der Linden; Jan-Willem Arends; Jürgen Müllberg; Hennie Hoogenboom
A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized.
The American journal of pathology 2002;160(5):1597-608.
2002: George L Scheffer; Anneke W Reurs; B Jutten; S H W Beiboer; R van Amerongen; Martijn Schoester; Erik A C Wiemer; Hennie Hoogenboom; Rik J Scheper
Selection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein.
British journal of cancer 2002;86(6):954-62.
2002: Patrick Chames; Hennie Hoogenboom; Paula Maria Henderikx
Selection of antibodies against biotinylated antigens.
Methods in molecular biology (Clifton, N.J.) 2002;178():147-57.
2002: Hennie Hoogenboom
Overview of antibody phage-display technology and its applications.
Methods in molecular biology (Clifton, N.J.) 2002;178():1-37.
2001: Ralph A Willemsen; Reno Debets; EH Hart; Hennie Hoogenboom; Reinder L H Bolhuis; Patrick Chames
A phage display selected fab fragment with MHC class I-restricted specificity for MAGE-A1 allows for retargeting of primary human T lymphocytes.
Gene therapy 2001;8(21):1601-8.
2001: Rob C Roovers; Edith Van Der Linden; H Zijlema; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
Evidence for a bias toward intracellular antigens in the local humoral anti-tumor immune response of a colorectal cancer patient revealed by phage display.
International journal of cancer. Journal international du cancer 2001;93(6):832-40.
2001: Twan van den Beucken; N Van Neer; Erwin Sablon; J Desmet; L Celis; Hennie Hoogenboom; Simon E Hufton
Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains.
Journal of molecular biology 2001;310(3):591-601.
2001: Rob C Roovers; Edith Van Der Linden; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
In vitro characterisation of a monovalent and bivalent form of a fully human anti Ep-CAM phage antibody.
Cancer immunology, immunotherapy : CII 2001;50(1):51-9.
2001: Rob C Roovers; Edith Van Der Linden; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
Identification of colon tumour-associated antigens by phage antibody selections on primary colorectal carcinoma.
European journal of cancer (Oxford, England : 1990) 2001;37(4):542-9.
2001: A Todorovska; Rob C Roovers; Olan Dolezal; Alexander A Kortt; Hennie Hoogenboom; Peter J Hudson
Design and application of diabodies, triabodies and tetrabodies for cancer targeting.
Journal of immunological methods 2001;248(1-2):47-66.
2000: Hennie Hoogenboom; Patrick Chames
Natural and designer binding sites made by phage display technology.
Immunology today 2000;21(8):371-8.
2000: Patrick Chames; Simon E Hufton; Pierre G Coulie; Barbara Uchanska-Ziegler; Hennie Hoogenboom
Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7969-74.
2000: Alexander Klimka; Bärbel Matthey; Rob C Roovers; Stefan Barth; Jan-Willem Arends; Andreas Engert; Hennie Hoogenboom
Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning.
British journal of cancer 2000;83(2):252-60.
2000: Simon E Hufton; N Van Neer; T van den Beuken; J Desmet; Erwin Sablon; Hennie Hoogenboom
Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands.
FEBS letters 2000;475(3):225-31.
2000: S H Beiboer; Anneke W Reurs; Rob C Roovers; Jan-Willem Arends; Nick R Whitelegg; Anthony R Rees; Hennie Hoogenboom
Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.
Journal of molecular biology 2000;296(3):833-49.
2000: M Lener; IR Horn; Alessio Cardinale; samantha messina; U B Nielsen; Susanna M Rybak; Hennie Hoogenboom; Antonino Cattaneo; Silvia Biocca
Diverting a protein from its cellular location by intracellular antibodies. The case of p21Ras.
European journal of biochemistry / FEBS 2000;267(4):1196-205.
1999: Dianne L Newton; D Pollock; P DiTullio; Yann Echelard; M Harvey; B Wilburn; J Williams; Hennie Hoogenboom; J C Raus; Harry M Meade; Susanna M Rybak
Antitransferrin receptor antibody-RNase fusion protein expressed in the mammary gland of transgenic mice.
Journal of immunological methods 1999;231(1-2):159-67.
1999: R Mutuberria; Hennie Hoogenboom; Edith Van Der Linden; Adriaan P de Bruïne; Rob C Roovers
Model systems to study the parameters determining the success of phage antibody selections on complex antigens.
Journal of immunological methods 1999;231(1-2):65-81.
1999: Simon E Hufton; Peter Moerkerk; E V Meulemans; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
Phage display of cDNA repertoires: the pVI display system and its applications for the selection of immunogenic ligands.
Journal of immunological methods 1999;231(1-2):39-51.
1999: IR Horn; A Wittinghofer; Adriaan P de Bruïne; Hennie Hoogenboom
Selection of phage-displayed fab antibodies on the active conformation of ras yields a high affinity conformation-specific antibody preventing the binding of c-Raf kinase to Ras.
FEBS letters 1999;463(1-2):115-20.
1999: Simon E Hufton; Peter Moerkerk; Ricardo J M G E Brandwijk; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization.
FEBS letters 1999;463(1-2):77-82.
1999: Adriaan P de Bruïne; J W Arends; Hennie Hoogenboom
[Immunology in the medical practice. XXIV. Expression of antibodies on bacteriophages; possibilities for in vitro production of human antibodies for any desired application].
Nederlands tijdschrift voor geneeskunde 1999;143(45):2256-61.
1999: Stewart D Nuttall; M J Rousch; Robert A Irving; Simon E Hufton; Hennie Hoogenboom; Peter J Hudson
Design and expression of soluble CTLA-4 variable domain as a scaffold for the display of functional polypeptides.
Proteins 1999;36(2):217-27.
1999: Hans de Haard; N Van Neer; Anneke W Reurs; Simon E Hufton; Rob C Roovers; Paula Maria Henderikx; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies.
The Journal of biological chemistry 1999;274(26):18218-30.
1999: Alexander Klimka; Stefan Barth; Bärbel Matthey; Rob C Roovers; Hilmar Lemke; Hinrich Hansen; Jan-Willem Arends; Volker Diehl; Hennie Hoogenboom; Andreas Engert
An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETA') is a potent immunotoxin against a Hodgkin-derived cell line.
British journal of cancer 1999;80(8):1214-22.
1999: J P Juwana; Paula Maria Henderikx; Axel Mischo; Andreas Wadle; Natalie Fadle; K Gerlach; Jan-Willem Arends; Hennie Hoogenboom; Michael Pfreundschuh; Christoph Renner
EB/RP gene family encodes tubulin binding proteins.
International journal of cancer. Journal international du cancer 1999;81(2):275-84.
1999: Hennie Hoogenboom; JT Lutgerink; Maurice Pelsers; M J Rousch; J Coote; N Van Neer; Adriaan P de Bruïne; Frans A van Nieuwenhoven; Jan F C Glatz; Jan-Willem Arends
Selection-dominant and nonaccessible epitopes on cell-surface receptors revealed by cell-panning with a large phage antibody library.
European journal of biochemistry / FEBS 1999;260(3):774-84.
1999: Maurice Pelsers; JT Lutgerink; F A Nieuwenhoven; Narendra Tandon; Ger J van der Vusse; Jan-Willem Arends; Hennie Hoogenboom; Jan F C Glatz
A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes.
The Biochemical journal 1999;337 ( Pt 3)():407-14.
1999: L Persic; IR Horn; Susanna M Rybak; Antonino Cattaneo; Hennie Hoogenboom; Andrew Bradbury
Single-chain variable fragments selected on the 57-76 p21Ras neutralising epitope from phage antibody libraries recognise the parental protein.
FEBS letters 1999;443(2):112-6.
1999: E Andersson; Paula Maria Henderikx; Elias Krambovitis; Hennie Hoogenboom; Carl A K Borrebaeck
A tandem repeat of MUC1 core protein induces a weak in vitro immune response in human B cells.
Cancer immunology, immunotherapy : CII 1999;47(5):249-56.
1998: Hans de Haard; B Kazemier; A van der Bent; P Oudshoorn; Piet J Boender; B van Gemen; Jan-Willem Arends; Hennie Hoogenboom
Absolute conservation of residue 6 of immunoglobulin heavy chain variable regions of class IIA is required for correct folding.
Protein engineering 1998;11(12):1267-76.
1998: J J de Haard; B Kazemier; P Oudshoorn; Piet J Boender; B van Gemen; M J Koolen; G van der Groen; Hennie Hoogenboom; Jan-Willem Arends
Selection of human anti-human immunodeficiency virus type 1 envelope single-chain antibodies from a peripheral blood cell-based phage repertoire.
The Journal of general virology 1998;79 ( Pt 12)():2883-94.
1998: Rob C Roovers; Paula Maria Henderikx; Wijnand Helfrich; Edith Van Der Linden; Anneke W Reurs; Adriaan P de Bruïne; Jan-Willem Arends; Lou de Leij; Hennie Hoogenboom
High-affinity recombinant phage antibodies to the pan-carcinoma marker epithelial glycoprotein-2 for tumour targeting.
British journal of cancer 1998;78(11):1407-16.
1998: Paula Maria Henderikx; M Kandilogiannaki; C Petrarca; Silvia von Mensdorff-Pouilly; JH Hilgers; Elias Krambovitis; Jan-Willem Arends; Hennie Hoogenboom
Human single-chain Fv antibodies to MUC1 core peptide selected from phage display libraries recognize unique epitopes and predominantly bind adenocarcinoma.
Cancer research 1998;58(19):4324-32.
1998: M Rousch; JT Lutgerink; J Coote; Adriaan P de Bruïne; Jan-Willem Arends; Hennie Hoogenboom
Somatostatin displayed on filamentous phage as a receptor-specific agonist.
British journal of pharmacology 1998;125(1):5-16.
1998: Hans de Haard; B Kazemier; M J Koolen; L J Nijholt; R H Meloen; B van Gemen; Hennie Hoogenboom; Jan-Willem Arends
Selection of recombinant, library-derived antibody fragments against p24 for human immunodeficiency virus type 1 diagnostics.
Clinical and diagnostic laboratory immunology 1998;5(5):636-44.
1998: Hennie Hoogenboom; Adriaan P de Bruïne; Simon E Hufton; R M Hoet; Jan-Willem Arends; Rob C Roovers
Antibody phage display technology and its applications.
Immunotechnology : an international journal of immunological engineering 1998;4(1):1-20.
1998: Wijnand Helfrich; Bart-Jan Kroesen; Rob C Roovers; L Westers; Grietje Molema; Hennie Hoogenboom; Lou de Leij
Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas.
International journal of cancer. Journal international du cancer 1998;76(2):232-9.
1998: Simon E Hufton; Peter Moerkerk; AP de Bruine; Jan-Willem Arends; Hennie Hoogenboom
Serological antigen selection of phage displayed colorectal tumour cDNA libraries.
Biochemical Society transactions 1998;26(1):S5.
1997: L Persic; A Roberts; J Wilton; Antonino Cattaneo; Andrew Bradbury; Hennie Hoogenboom
An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries.
Gene 1997;187(1):9-18.
1997: L Persic; MC Righi; A Roberts; Hennie Hoogenboom; Antonino Cattaneo; Andrew Bradbury
Targeting vectors for intracellular immunisation.
Gene 1997;187(1):1-8.
1997: Hennie Hoogenboom
Designing and optimizing library selection strategies for generating high-affinity antibodies.
Trends in biotechnology 1997;15(2):62-70.
1996: B Kazemier; Hans de Haard; Piet J Boender; B van Gemen; Hennie Hoogenboom
Determination of active single chain antibody concentrations in crude periplasmic fractions.
Journal of immunological methods 1996;194(2):201-9.