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Zhenyu Sheng

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Chemicals & Drugs

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Publications

TOP 3
Sara E Cnudde; Zhenyu Sheng; Xaofei Jia; Francis J Castellino; James H Geiger
The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer.
Leticia I Llarrull; Zhenyu Sheng; Shahriar Mobashery
Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.
Sara E Cnudde; Zhenyu Sheng; Francis J Castellino; James H Geiger
Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.

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All Publications

2011: Sara E Cnudde; Zhenyu Sheng; Xaofei Jia; Francis J Castellino; James H Geiger
The crystal structure of the calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2011;16(2):257-66.
2010: Leticia I Llarrull; Zhenyu Sheng; Shahriar Mobashery
Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus.
Biochemistry 2010;49(37):7975-7.
2010: Sara E Cnudde; Zhenyu Sheng; Francis J Castellino; James H Geiger
Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd(2+)/Mg (2+)-con-T[K7gamma] complex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2010;15(5):667-75.
2010: Mariana Figuera-Losada; Marie Ranson; Martina L Sanderson-Smith; Mark J Walker; Francis J Castellino; Zhenyu Sheng
Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM).
Biochimica et biophysica acta 2010;1804(6):1342-9.
2009: Zhenyu Sheng; Zhong Liang; James H Geiger; Zhenyu Sheng; Francis J Castellino
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B.
Neuropharmacology 2009;57(2):127-36.
2009: Qiuyun Dai; Cai Xiao; Mingxin Dong; Zhuguo Liu; Zhenyu Sheng; Francis J Castellino; Zhenyu Sheng
Non-strict strand orientation of the Ca2+-induced dimerization of a conantokin peptide variant with sequence-shifted gamma-carboxyglutamate residues.
Peptides 2009;30(5):866-72.
2008: Zhenyu Sheng; Zhenyu Sheng; Brigid E Brown; Francis J Castellino
N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.
Neuropharmacology 2008;55(2):204-14.
2008: Qihua Fu; Mariana Figuera-Losada; Victoria A Ploplis; Sara Cnudde; James H Geiger; Zhenyu Sheng; Francis J Castellino
The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.
The Journal of biological chemistry 2008;283(3):1580-7.
2007: Zhenyu Sheng; Qiuyun Dai; Zhenyu Sheng; Francis J Castellino
Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides.
Neuropharmacology 2007;53(1):145-56.
2007: Zhenyu Sheng; Francis J Castellino
The molecular basis of conantokin antagonism of NMDA receptor function.
Current drug targets 2007;8(5):633-42.
2007: Qiuyun Dai; Zhenyu Sheng; James H Geiger; Francis J Castellino; Zhenyu Sheng
Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives.
The Journal of biological chemistry 2007;282(17):12641-9.
2007: Sara E Cnudde; Zhenyu Sheng; Qiuyun Dai; Francis J Castellino; James H Geiger
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.
Journal of the American Chemical Society 2007;129(6):1586-93.
2006: Sara E Cnudde; Zhenyu Sheng; Francis J Castellino; James H Geiger
X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM.
Biochemistry 2006;45(37):11052-60.
2006: Juanjuan Wei; Mingxin Dong; Cai Xiao; Fengchao Jiang; Francis J Castellino; Zhenyu Sheng; Qiuyun Dai
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice.
Neuroscience letters 2006;405(1-2):137-41.
2006: Lizette Busquets; Hector Guillen-Ahlers; Melanie E DeFord; Mark A Suckow; Rudolph M Navari; Francis J Castellino; Zhenyu Sheng
Cathepsin E is a specific marker of dysplasia in APC mouse intestine.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2006;27(1):36-42.
2005: Qiuyun Dai; Zhenyu Sheng; Francis J Castellino
Role of the hexapeptide disulfide loop in the gamma-carboxyglutamic acid domain of protein C in Ca2+-mediated structural and functional properties.
Biochemistry 2005;44(37):12508-14.
2004: Rong Yang; Zhenyu Sheng; Francis J Castellino; David P Weliky
A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate.
Journal of the American Chemical Society 2004;126(45):14722-3.
2004: Qiuyun Dai; Francis J Castellino; Zhenyu Sheng
A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide.
Biochemistry 2004;43(41):13225-32.
2004: Jun Yang; Zhenyu Sheng; Francis J Castellino; David P Weliky
Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers.
Biophysical journal 2004;87(3):1951-63.
2004: Qiuyun Dai; Zhenyu Sheng; Francis J Castellino
A new mechanism for metal ion-assisted interchain helix assembly in a naturally occurring peptide mediated by optimally spaced gamma-carboxyglutamic acid residues.
Journal of molecular biology 2004;336(3):731-44.
2003: Qiuyun Dai; Jaroslav Zajicek; Francis J Castellino; Zhenyu Sheng
Binding and orientation of conantokins in PL vesicles and aligned PL multilayers.
Biochemistry 2003;42(43):12511-21.
2003: Lakshmi V Mundada; Zhenyu Sheng; Melanie E DeFord; Mariana Figuera; Francis J Castellino; William P Fay
Structure-function analysis of the streptokinase amino terminus (residues 1-59).
The Journal of biological chemistry 2003;278(27):24421-7.
2003: RC Klein; Zhenyu Sheng; Francis J Castellino
Direct binding properties of conantokins to native N-methyl-d-aspartate receptors.
The journal of peptide research : official journal of the American Peptide Society 2003;61(6):307-17.
2001: RC Klein; SE Warder; Zygmunt Galdzicki; Francis J Castellino; Zhenyu Sheng
Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides.
Neuropharmacology 2001;41(7):801-10.
2001: RC Klein; Zhenyu Sheng; Zygmunt Galdzicki; Francis J Castellino
The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors.
The Journal of biological chemistry 2001;276(29):26860-7.
2001: SE Warder; T Blandl; RC Klein; Francis J Castellino; Zhenyu Sheng
Amino acid determinants for NMDA receptor inhibition by conantokin-T.
Journal of neurochemistry 2001;77(3):812-22.
2001: T Blandl; Jaroslav Zajicek; Zhenyu Sheng; Francis J Castellino
Sequence requirements for the N-methyl-D-aspartate receptor antagonist activity of conantokin-R.
The Journal of biological chemistry 2001;276(10):7391-6.
2000: M M Schenone; SE Warder; J A Martin; Zhenyu Sheng; Francis J Castellino
An internal histidine residue from the bacterial surface protein, PAM, mediates its binding to the kringle-2 domain of human plasminogen.
The journal of peptide research : official journal of the American Peptide Society 2000;56(6):438-45.
2000: Francis J Castellino; Zhenyu Sheng
Conantokins: inhibitors of ion flow through the N-methyl-D-aspartate receptor channels.
Current drug targets 2000;1(3):219-35.
2000: T Blandl; SE Warder; Zhenyu Sheng; Francis J Castellino
Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R.
FEBS letters 2000;470(2):139-46.
1999: SL Nilsen; Zhenyu Sheng; Francis J Castellino
Enhancement through mutagenesis of the binding of the isolated kringle 2 domain of human plasminogen to omega-amino acid ligands and to an internal sequence of a Streptococcal surface protein.
The Journal of biological chemistry 1999;274(32):22380-6.
1999: T Blandl; SE Warder; Zhenyu Sheng; Francis J Castellino
Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T.
The journal of peptide research : official journal of the American Peptide Society 1999;53(4):453-64.
1999: RG Miele; Zhenyu Sheng; V A Costa; Francis J Castellino
Glycosylation of asparagine-28 of recombinant staphylokinase with high-mannose-type oligosaccharides results in a protein with highly attenuated plasminogen activator activity.
The Journal of biological chemistry 1999;274(12):7769-76.
1998: T Blandl; Zhenyu Sheng; Francis J Castellino
NMDA-receptor antagonist requirements in conantokin-G.
FEBS letters 1998;435(2-3):257-62.
1998: Zhenyu Sheng; Francis J Castellino
Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T.
The Journal of biological chemistry 1998;273(31):19573-8.
1998: Z Chen; T Blandl; Zhenyu Sheng; SE Warder; Lei Li; Y Zhu; L G Pedersen; Feng Ni; Francis J Castellino
Conformational changes in conantokin-G induced upon binding of calcium and magnesium as revealed by NMR structural analysis.
The Journal of biological chemistry 1998;273(26):16248-58.
1998: SE Warder; Zhenyu Sheng; Z Chen; Lei Li; Y Zhu; L G Pedersen; Feng Ni; Francis J Castellino
The roles of individual gamma-carboxyglutamate residues in the solution structure and cation-dependent properties of conantokin-T.
The Journal of biological chemistry 1998;273(13):7512-22.
1997: T Blandl; Jaroslav Zajicek; Zhenyu Sheng; Francis J Castellino
Metal-ion-binding properties of synthetic conantokin-G.
The Biochemical journal 1997;328 ( Pt 3)():777-83.
1997: SE Warder; Z Chen; Y Zhu; Zhenyu Sheng; Francis J Castellino; Feng Ni
The NMR solution structure of the NMDA receptor antagonist, conantokin-T, in the absence of divalent metal ions.
FEBS letters 1997;411(1):19-26.
1997: H Wang; Zhenyu Sheng; Roger K Bretthauer; Francis J Castellino
Serine-578 is a major phosphorylation locus in human plasma plasminogen.
Biochemistry 1997;36(26):8100-6.
1997: SL Nilsen; Melanie E DeFord; Zhenyu Sheng; B A Chibber; Roger K Bretthauer; Francis J Castellino
High-level secretion in Pichia pastoris and biochemical characterization of the recombinant kringle 2 domain of tissue-type plasminogen activator.
Biotechnology and applied biochemistry 1997;25 ( Pt 1)():63-74.
1996: Zhenyu Sheng; SE Warder; T Blandl; Francis J Castellino
Calcium binding properties of synthetic gamma-carboxyglutamic acid-containing marine cone snail "sleeper" peptides, conantokin-G and conantokin-T.
Biochemistry 1996;35(51):16528-34.
1996: Zhenyu Sheng; J P Geng; SE Warder; Francis J Castellino
The entire gamma-carboxyglutamic acid- and helical stack-domains of human coagulation factor IX are required for optimal binding to its endothelial cell receptor.
International journal of peptide and protein research 1996;48(3):281-5.
1995: W T Christiansen; L R Jalbert; R M Robertson; A Jhingan; Zhenyu Sheng; Francis J Castellino
Hydrophobic amino acid residues of human anticoagulation protein C that contribute to its functional binding to phospholipid Vesicles.
Biochemistry 1995;34(33):10376-82.
1995: T L Colpitts; Zhenyu Sheng; Francis J Castellino
Binding of calcium to individual gamma-carboxyglutamic acid residues of human protein C.
Biochemistry 1995;34(8):2424-30.