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Stephane Plaisance

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Mouse

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Lymphangiogenesis

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Publications

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Sonja Loges; Thomas Schmidt; Marc Tjwa; Katie van Geyte; Dirk Lievens; Esther Lutgens; Davy Vanhoutte; Delphine Borgel; Stephane Plaisance; Marc Hoylaerts; Aernout Luttun; Mieke Dewerchin; Bart Jonckx; Peter Carmeliet
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.
Marc Tjwa; Rute Moura; Lieve Moons; Stephane Plaisance; Maria De Mol; Sandra Jansen; Mieke Dewerchin; Catherine Verfaillie; Peter Carmeliet
Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.
Mieke Delvaeye; Marina Noris; Astrid De Vriese; Charles T Esmon; Naomi L Esmon; Gary Ferrell; Jurgen Del-Favero; Stephane Plaisance; Bart Claes; Diether Lambrechts; Carla Zoja; Giuseppe Remuzzi; Edward M Conway
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.

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All Publications

2010: Sonja Loges; Thomas Schmidt; Marc Tjwa; Katie van Geyte; Dirk Lievens; Esther Lutgens; Davy Vanhoutte; Delphine Borgel; Stephane Plaisance; Marc Hoylaerts; Aernout Luttun; Mieke Dewerchin; Bart Jonckx; Peter Carmeliet
Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6.
Blood 2010;115(11):2264-73.
2009: Marc Tjwa; Rute Moura; Lieve Moons; Stephane Plaisance; Maria De Mol; Sandra Jansen; Mieke Dewerchin; Catherine Verfaillie; Peter Carmeliet
Fibrinolysis-independent role of plasmin and its activators in the haematopoietic recovery after myeloablation.
Journal of cellular and molecular medicine 2009;13(11-12):4587-95.
2009: Mieke Delvaeye; Marina Noris; Astrid De Vriese; Charles T Esmon; Naomi L Esmon; Gary Ferrell; Jurgen Del-Favero; Stephane Plaisance; Bart Claes; Diether Lambrechts; Carla Zoja; Giuseppe Remuzzi; Edward M Conway
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
The New England journal of medicine 2009;361(4):345-57.
2008: Annelii Ny; Marta Koch; Wouter Vandevelde; Martin Schneider; Christian Fischer; Antonio Diez-juan; Elke Neven; Ilse Geudens; Sunit Maity; Lieve Moons; Stephane Plaisance; Diether Lambrechts; Peter Carmeliet; Mieke Dewerchin
Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles.
Blood 2008;112(5):1740-9.
2008: Marc Tjwa; Lola Bellido-Martin; Yuan Lin; Esther Lutgens; Stephane Plaisance; Françoise Bono; Nathalie Delesque-Touchard; Caroline Hervé; Rute Moura; An D Billiau; Cristina Aparicio; Marcel Levi; Mat Daemen; Mieke Dewerchin; Florea Lupu; Jef Arnout; Jean-Marc Herbert; Mark Waer; Pablo García de Frutos; Björn Dahlbäck; Peter Carmeliet; Marc F Hoylaerts; Lieve Moons
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
Blood 2008;111(8):4096-105.
2008: Anne Angelillo-Scherrer; Laurent Burnier; Diether Lambrechts; Richard J Fish; Marc Tjwa; Stephane Plaisance; Rocco Sugamele; Maria DeMol; Eduardo Martinez-Soria; Patrick H Maxwell; Greg Lemke; Stephen P Goff; Glenn K Matsushima; Henry Earp; Marc Chanson; Désiré Collen; Shozo Izui; Marc Schapira; Edward M Conway; Peter Carmeliet
Role of Gas6 in erythropoiesis and anemia in mice.
The Journal of clinical investigation 2008;118(2):583-96.
2007: Christian Fischer; Bart Jonckx; Massimiliano Mazzone; Serena Zacchigna; Sonja Loges; Lucia Pattarini; Emmanuel Chorianopoulos; Laurens Liesenborghs; Marta Koch; Maria De Mol; Monica Autiero; Sabine Wyns; Stephane Plaisance; Lieve Moons; Nico van Rooijen; Mauro Giacca; Jean Marie Stassen; Mieke Dewerchin; Désiré Collen; Peter Carmeliet
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels.
Cell 2007;131(3):463-75.
2006: Marlies Van de Wouwer; Stephane Plaisance; Astrid De Vriese; E Waelkens; Désiré Collen; J Persson; M R Daha; Edward M Conway
The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis.
Journal of thrombosis and haemostasis : JTH 2006;4(8):1813-24.
2005: Annelii Ny; Marta Koch; Martin Schneider; Elke Neven; Ricky T Tong; Sunit Maity; Christian Fischer; Stephane Plaisance; Diether Lambrechts; Christophe Héligon; Sven Terclavers; Malgorzata Ciesiolka; Roland Kälin; Wing Yan Man; Irena Senn; Sabine Wyns; Florea Lupu; André Brändli; Kris Vleminckx; Désiré Collen; Mieke Dewerchin; Edward M Conway; Lieve Moons; Rakesh K Jain; Peter Carmeliet
A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Nature medicine 2005;11(9):998-1004.
2005: Anne Angelillo-Scherrer; Laurent Burnier; Nathalie Flores; Pierre Savi; Maria DeMol; Paul Schaeffer; Jean-Marc Herbert; Greg Lemke; Stephen P Goff; Glenn K Matsushima; Henry Earp; Christian Vesin; Marc F Hoylaerts; Stephane Plaisance; Désiré Collen; Edward M Conway; Bernhard Wehrle-Haller; Peter Carmeliet
Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.
The Journal of clinical investigation 2005;115(2):237-46.
2003: Monica Autiero; Johannes Waltenberger; David Communi; Andrea Kranz; Lieve Moons; Diether Lambrechts; Jens Kroll; Stephane Plaisance; Maria De Mol; Françoise Bono; Stefanie Kliche; Guido Fellbrich; Kurt Ballmer-Hofer; Domenico Maglione; Ulrike Mayr-Beyrle; Mieke Dewerchin; Saskia Dombrowski; Danica Stanimirovic; Paul van Hummelen; Christoph Dehio; Daniel J Hicklin; Graziella Persico; Jean-Marc Herbert; David Communi; Masabumi Shibuya; Désiré Collen; Edward M Conway; Peter Carmeliet
Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1.
Nature medicine 2003;9(7):936-43.
2003: Ingeborg Stalmans; Diether Lambrechts; Frederik De Smet; Sandra Jansen; Jian Wang; Sunit Maity; Paige Kneer; Maren von der Ohe; Ann Swillen; Christa Maes; Marc Gewillig; Daniel G M Molin; Peter Hellings; Thurid Boetel; Maartin Haardt; Veerle Compernolle; Mieke Dewerchin; Stephane Plaisance; Robert Francois Vlietinck; Beverly Emanuel; Adriana C Gittenberger-de Groot; Peter Scambler; Bernice E Morrow; Deborah A Driscol; Lieve Moons; Camila V Esguerra; Geert Carmeliet; Annett Behn-Krappa; koenraad devriendt; Désiré Collen; Simon J Conway; Peter Carmeliet
VEGF: a modifier of the del22q11 (DiGeorge) syndrome?
Nature medicine 2003;9(2):173-82.
2002: Veerle Compernolle; Koen Brusselmans; Till Acker; Peter Hoet; Marc Tjwa; Heike Beck; Stephane Plaisance; Yuval Dor; Eli Keshet; Florea Lupu; Benoit Nemery; Mieke Dewerchin; Paul P Van Veldhoven; Karl H Plate; Lieve Moons; Désiré Collen; Peter Carmeliet
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice.
Nature medicine 2002;8(7):702-10.
2002: Petra A M Warmerdam; Stephane Plaisance; Kristel Vanderlick; Petra Vandervoort; Kathleen Brepoels; Désiré Collen; Marc De Maeyer
Elimination of a human T-cell region in staphylokinase by T-cell screening and computer modeling.
Thrombosis and haemostasis 2002;87(4):666-73.
2002: Petra A M Warmerdam; Kristel Vanderlick; Petra Vandervoort; Heidi De Smedt; Stephane Plaisance; Marc De Maeyer; Désiré Collen
Staphylokinase-specific cell-mediated immunity in humans.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(1):155-61.
2000: Karolien De Bosscher; Wim Vanden Berghe; Linda Vermeulen; Stephane Plaisance; Elke Boone; Guy Haegeman
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3919-24.
2000: S Vanwetswinkel; Stephane Plaisance; Z Zhi-Yong; I Vanlinthout; Kathleen Brepoels; Ignace Lasters; Désiré Collen; L Jespers
Pharmacokinetic and thrombolytic properties of cysteine-linked polyethylene glycol derivatives of staphylokinase.
Blood 2000;95(3):936-42.
1999: Wim Vanden Berghe; Karolien De Bosscher; Elke Boone; Stephane Plaisance; Guy Haegeman
The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.
The Journal of biological chemistry 1999;274(45):32091-8.
1999: Jan Gabriels; MC Beckers; H Ding; Astrid De Vriese; Stephane Plaisance; Silvère M van der Maarel; George W Padberg; R R Frants; Jane E Hewitt; Désiré Collen; A Belayew
Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element.
Gene 1999;236(1):25-32.
1998: H Ding; MC Beckers; Stephane Plaisance; Peter Marynen; Désiré Collen; A Belayew
Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.
Human molecular genetics 1998;7(11):1681-94.
1998: Wim Vanden Berghe; Stephane Plaisance; Elke Boone; Karolien De Bosscher; M Lienhard Schmitz; Walter Fiers; Guy Haegeman
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.
The Journal of biological chemistry 1998;273(6):3285-90.
1998: E Decoster; B Vanhaesebroeck; Elke Boone; Stephane Plaisance; K De Vos; Guy Haegeman; Johan Grooten; Walter Fiers
Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
The Journal of biological chemistry 1998;273(6):3271-7.
1997: Karolien De Bosscher; M Lienhard Schmitz; Wim Vanden Berghe; Stephane Plaisance; Walter Fiers; Guy Haegeman
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13504-9.
1997: Stephane Plaisance; Wim Vanden Berghe; Elke Boone; Walter Fiers; Guy Haegeman
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.
Molecular and cellular biology 1997;17(7):3733-43.
1996: Rudi Beyaert; A Cuenda; Wim Vanden Berghe; Stephane Plaisance; J C Lee; Guy Haegeman; P Cohen; Walter Fiers
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
1995: D Han; Stephane Plaisance; Eric Rubinstein; A Alileche; C Pottin-Clemenceau; T S Kim; Edward P Cohen; Claude Jasmin; Bruno Azzarone
Non random activation of endogenous interleukin-2, (IL-2), IL-2 receptor alpha and IL-2 receptor beta genes after transfection of mouse fibroblasts with a cDNA for the alpha chain of the human IL-2 receptor.
European journal of immunology 1995;25(7):1905-12.
1995: P Krief; D Lawrence; A Alileche; Stephane Plaisance; Claude Jasmin; M Semmel
Purification and characterization of a factor which inhibits retrovirus replication.
Research in virology 1995;146(2):113-23.
1995: Walter Fiers; Rudi Beyaert; Elke Boone; Sigrid Cornelis; Wim Declercq; E Decoster; Geertrui Denecker; B Depuydt; D De Valck; G De Wilde; Vera Goossens; Johan Grooten; Guy Haegeman; Karen Heyninck; Louis C Penning; Stephane Plaisance; Katia Vancompernolle; Wim van Criekinge; Peter Vandenabeele; Wim Vanden Berghe; M Van de Craen; V Vandevoorde; Dominique Vercammen
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
1994: P Krief; Yvette Augery-Bourget; Stephane Plaisance; M F Merck; E Assier; V Tanchou; Martine Billard; Claude Boucheix; Claude Jasmin; Bruno Azzarone
A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization.
Oncogene 1994;9(12):3449-56.
1994: M Semmel; Antonio Macho; D Coulaud; A Alileche; Stephane Plaisance; J Aguilar; Claude Jasmin
Effect of retinoic acid on HL-60 cells infected with human immunodeficiency virus type 1.
Blood 1994;84(8):2480-8.
1994: Stephane Plaisance; A Alileche; D Han; Eric Rubinstein; Y Sahraoui; Claude Jasmin; Bruno Azzarone
How interleukin-2 can affect human fibroblasts behaviour.
Pathology, research and practice 1994;190(9-10):942-9.
1994: A Alileche; D Han; Stephane Plaisance; E Assier; Y Sahraoui; C Clemanceau; D Metivier; D Brouty-Boyer; Claude Jasmin; Bruno Azzarone
IL-2 production by myofibroblasts from post-radiation fibrosis in breast cancer patients.
International immunology 1994;6(10):1585-91.
1993: Eric Rubinstein; Martine Billard; Stephane Plaisance; Michel Prenant; Claude Boucheix
Molecular cloning of the mouse equivalent of CD9 antigen.
Thrombosis research 1993;71(5):377-83.
1993: Stephane Plaisance; Eric Rubinstein; A Alileche; D S Han; Y Sahraoui; M C Mingari; R Bellomo; Donata Rimoldi; M P Colombo; Claude Jasmin
Human melanoma cells express a functional interleukin-2 receptor.
International journal of cancer. Journal international du cancer 1993;55(1):164-70.
1993: Stephane Plaisance; Eric Rubinstein; A Alileche; P Benoit; Claude Jasmin; Bruno Azzarone
The IL-2 receptor present on human embryonic fibroblasts is functional in the absence of P64/IL-2R gamma chain.
International immunology 1993;5(8):843-8.
1993: A Alileche; Stephane Plaisance; D S Han; Eric Rubinstein; C Mingari; R Bellomo; Claude Jasmin; Bruno Azzarone
Human melanoma cell line M14 secretes a functional interleukin 2.
Oncogene 1993;8(7):1791-6.
1993: Donata Rimoldi; S Salvi; F Hartmann; M Schreyer; S Blum; L Zografos; Stephane Plaisance; Bruno Azzarone; S Carrel
Expression of IL-2 receptors in human melanoma cells.
Anticancer research 1993;13(3):555-64.
1993: Eric Rubinstein; P Benoit; Martine Billard; Stephane Plaisance; Michel Prenant; Georges Uzan; Claude Boucheix
Organization of the human CD9 gene.
Genomics 1993;16(1):132-8.
1992: E Weidmann; M Sacchi; Stephane Plaisance; D S Heo; S Yasumura; W C Lin; Jonas T Johnson; Ronald Herberman; B Azzarone; Theresa L Whiteside
Receptors for interleukin 2 on human squamous cell carcinoma cell lines and tumor in situ.
Cancer research 1992;52(21):5963-70.
1992: M Semmel; Antonio Macho; V Morozov; D Coulaud; A Alileche; Stephane Plaisance; J Aguilar; Claude Jasmin
Replication of human immunodeficiency virus in HL-60 cells.
Research in virology 1992;143(4):249-58.
1992: Stephane Plaisance; Eric Rubinstein; A Alileche; Y Sahraoui; P Krief; Yvette Augery-Bourget; Claude Jasmin; H Suarez; Bruno Azzarone
Expression of the interleukin-2 receptor on human fibroblasts and its biological significance.
International immunology 1992;4(7):739-46.