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Isabelle Leclercq

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N Charette; Christine De Saeger; yves horsmans; Isabelle Leclercq; Peter Stärkel
Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms.
Regina Español-Suñer; Patrick Jacquemin; Younes Achouri; Rodolphe Carpentier; S Cordi; Vanessa Legry; Frédéric P Lemaigre; Noémi Van Hul; Isabelle Leclercq
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice.
Peter Stärkel; Isabelle Leclercq; Tanja Schneider-Merck; Jorge Abarca; Ivan Borbath; Nicolas Charette; Christine De Saeger; yves horsmans
Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.

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All Publications

2013: N Charette; Christine De Saeger; yves horsmans; Isabelle Leclercq; Peter Stärkel
Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms.
Cell death & disease 2013;4():e471.
2012: Regina Español-Suñer; Patrick Jacquemin; Younes Achouri; Rodolphe Carpentier; S Cordi; Vanessa Legry; Frédéric P Lemaigre; Noémi Van Hul; Isabelle Leclercq
Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice.
Gastroenterology 2012;143(6):1564-1575.e7.
2012: Peter Stärkel; Isabelle Leclercq; Tanja Schneider-Merck; Jorge Abarca; Ivan Borbath; Nicolas Charette; Christine De Saeger; yves horsmans
Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.
Molecular carcinogenesis 2012;51(10):816-25.
2012: Denis Rommel; Jorge Abarca-Quinones; Christine De Saeger; Isabelle Leclercq; Frank Peeters; Thierry Duprez
Enhanced choline metabolism in a rodent rhabdomyosarcoma model: correlation between RT-PCR and translational 3 T H-MRS.
Magnetic resonance imaging 2012;30(7):1010-6.
2011: Isabelle Leclercq; Derrick M Van Rooyen; Geoffrey C Farrell
Hepatic endoplasmic reticulum stress in obesity: deeper insights into processes, but are they relevant to nonalcoholic steatohepatitis?
Hepatology (Baltimore, Md.) 2011;54(6):2260-5.
2011: Nicolas Lanthier; Patrice Cani; yves horsmans; Olivier Molendi-Coste; Nico van Rooijen; Isabelle Leclercq
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(12):4301-11.
2011: Noémi Van Hul; Nico van Rooijen; Jorge Abarca Quinones; Regina Español Suñer; Nicolas Lanthier; Isabelle Leclercq
Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.
The American journal of pathology 2011;179(4):1839-50.
2011: Rodolphe Carpentier; S Cordi; Patrick Jacquemin; Janel L Kopp; Isabelle Leclercq; Sébastien Lepreux; Peggy Raynaud; Maike Sander; Regina Español Suñer; Noémi van Hul; Aline Antoniou; Jean-Bernard Beaudry; Frédéric P Lemaigre
Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells.
Gastroenterology 2011;141(4):1432-8, 1438.e1-4.
2011: O Molendi-Coste; V Legry; Isabelle Leclercq
Are n-3 PUFA dietary recommendations met in in-hospital and school catering?
Acta gastro-enterologica Belgica 2011;74(2):281-8.
2011: Barbara D Pachikian; Laurence Portois; Florence M Sohet; Patrice Cani; Yvon A Carpentier; Emilie Catry; Fabienne C De Backer; Nicolas Dejeans; Louise Deldicque; Jean-Baptiste Demoulin; Evelyne M Dewulf; Ahmed Essaghir; Fabienne Foufelle; Marc Francaux; Isabelle Leclercq; Olivier Molendi-Coste; Giulio G Muccioli; Audrey M Neyrinck; Nathalie M Delzenne
Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.
PloS one 2011;6(8):e23365.
2010: Peter Stärkel; Christine De Saeger; Alastair J Strain; Isabelle Leclercq; yves horsmans
NFkappaB, cytokines, TLR 3 and 7 expression in human end-stage HCV and alcoholic liver disease.
European journal of clinical investigation 2010;40(7):575-84.
2010: Alain da Silva Morais; Jorge Abarca-Quinones; Bruno Guigas; Benoit Viollet; Peter Stärkel; yves horsmans; Isabelle Leclercq
Development of hepatic fibrosis occurs normally in AMPK-deficient mice.
Clinical science (London, England : 1979) 2010;118(6):411-20.
2010: Ivan Borbath; Isabelle Leclercq; Christine Sempoux; Jorge Abarca-Quinones; Christine Desaeger; yves horsmans
Efficacy of lanreotide in preventing the occurrence of chemically induced hepatocellular carcinoma in rats.
Chemico-biological interactions 2010;183(1):238-48.
2010: Nicolas Charette; Christine De Saeger; Valérie Lannoy; yves horsmans; Isabelle Leclercq; Peter Stärkel
Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition.
Molecular cancer 2010;9():256.
2010: Nicolas Lanthier; Olivier Molendi-Coste; yves horsmans; Nico van Rooijen; Patrice D Cani; Isabelle Leclercq
Kupffer cell activation is a causal factor for hepatic insulin resistance.
American journal of physiology. Gastrointestinal and liver physiology 2010;298(1):G107-16.
2009: Najat Salameh; Benoît Larrat; Jorge Abarca-Quinones; Stéphane Pallu; Mylène Dorvillius; Isabelle Leclercq; Mathias Fink; Ralph Sinkus; Bernard E Van Beers
Early detection of steatohepatitis in fatty rat liver by using MR elastography.
Radiology 2009;253(1):90-7.
2009: Nghi Phung; Natasha Pera; Geoffrey Farrell; Isabelle Leclercq; Jing Yun Hou; Jacob George
Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis.
International journal of molecular medicine 2009;24(2):171-80.
2009: Jianhua Wang; Isabelle Leclercq; Joanne M Brymora; Ning Xu; Mehdi Ramezani-Moghadam; Roslyn M London; David Brigstock; Jacob George
Kupffer cells mediate leptin-induced liver fibrosis.
Gastroenterology 2009;137(2):713-23.
2009: Nicolas Lanthier; yves horsmans; Isabelle Leclercq
The metabolic syndrome: how it may influence hepatic stellate cell activation and hepatic fibrosis.
Current opinion in clinical nutrition and metabolic care 2009;12(4):404-11.
2009: Noémi K M Van Hul; Jorge Abarca-Quinones; Christine Sempoux; yves horsmans; Isabelle Leclercq
Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury.
Hepatology (Baltimore, Md.) 2009;49(5):1625-35.
2009: Alain Da Silva Morais; Valérie Lebrun; Jorge Abarca-Quinones; Sonia Brichard; Louis Hue; Bruno Guigas; Benoit Viollet; Isabelle Leclercq
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.
Journal of hepatology 2009;50(3):489-500.
2008: Isabelle Leclercq; yves horsmans
Nonalcoholic fatty liver disease: the potential role of nutritional management.
Current opinion in clinical nutrition and metabolic care 2008;11(6):766-73.
2008: Alain Da Silva Morais; Alain Saliez; Isabelle Leclercq; yves horsmans; Peter Stärkel
Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats.
Clinical science (London, England : 1979) 2008;114(1):73-83.
2007: Ivan Borbath; Isabelle Leclercq; Jorge Abarca-Quinones; Christine Desaeger; Valérie Lebrun; Pierre Moulin; Christine Sempoux; yves horsmans
Inhibition of early preneoplastic events in the rat liver by the somatostatin analog lanreotide.
Cancer science 2007;98(12):1831-9.
2007: Najat Salameh; Frank Peeters; Ralph Sinkus; Jorge Abarca-Quinones; Laurence Annet; Leon ter Beek; Isabelle Leclercq; Bernard E Van Beers
Hepatic viscoelastic parameters measured with MR elastography: correlations with quantitative analysis of liver fibrosis in the rat.
Journal of magnetic resonance imaging : JMRI 2007;26(4):956-62.
2007: Ivan Borbath; Isabelle Leclercq; Pierre Moulin; Christine Sempoux; yves horsmans
The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver.
European journal of cancer (Oxford, England : 1990) 2007;43(11):1755-63.
2007: Isabelle Leclercq; Alain Da Silva Morais; Ben Schroyen; Noémi Van Hul; Albert Geerts
Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences.
Journal of hepatology 2007;47(1):142-56.
2007: Peter Stärkel; Christine De Saeger; Isabelle Leclercq; yves horsmans
Role of signal transducer and activator of transcription 3 in liver fibrosis progression in chronic hepatitis C-infected patients.
Laboratory investigation; a journal of technical methods and pathology 2007;87(2):173-81.
2007: Aileen dela Peña; Isabelle Leclercq; Jacqueline Williams; Geoffrey C Farrell
NADPH oxidase is not an essential mediator of oxidative stress or liver injury in murine MCD diet-induced steatohepatitis.
Journal of hepatology 2007;46(2):304-13.
2007: Isabelle Leclercq
Pathogenesis of steatohepatitis: insights from the study of animal models.
Acta gastro-enterologica Belgica 2007;70(1):25-31.
2007: Laurence Annet; Frank Peeters; Jorge Abarca-Quinones; Isabelle Leclercq; Pierre Moulin; Bernard E Van Beers
Assessment of diffusion-weighted MR imaging in liver fibrosis.
Journal of magnetic resonance imaging : JMRI 2007;25(1):122-8.
2007: Alain Da Silva Morais; Jorge Abarca-Quinones; yves horsmans; Peter Stärkel; Isabelle Leclercq
Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice.
International journal of molecular medicine 2007;19(1):105-12.
2007: Isabelle Leclercq; Valérie A Lebrun; Peter Stärkel; yves horsmans
Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone.
Laboratory investigation; a journal of technical methods and pathology 2007;87(1):56-65.
2006: Isabelle Leclercq; Matthieu Vansteenberghe; Valérie Lebrun; Noémi K VanHul; Jorge Abarca-Quinones; Christine Sempoux; Christian Picard; Peter Stärkel; yves horsmans
Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptin.
Laboratory investigation; a journal of technical methods and pathology 2006;86(11):1161-71.
2006: Isabelle Leclercq; Christine Sempoux; Peter Stärkel; yves horsmans
Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats.
Gut 2006;55(7):1020-9.
2006: Jun Yu; Emilia Ip; Aileen dela Peña; Jing Y Hou; Jayshree Sesha; Natasha Pera; Pauline Hall; Richard Kirsch; Isabelle Leclercq; Geoffrey C Farrell
COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator.
Hepatology (Baltimore, Md.) 2006;43(4):826-36.
2006: MC Nollevaux; Yves Guiot; yves horsmans; Isabelle Leclercq; Jacques Rahier; André P Geubel; Christine Sempoux
Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(2):182-6.
2005: Stéphanie Laurent; yves horsmans; Peter Stärkel; Isabelle Leclercq; Christine Sempoux; Luc Lambotte
Disrupted NF- kappa B activation after partial hepatectomy does not impair hepatocyte proliferation in rats.
World journal of gastroenterology : WJG 2005;11(46):7345-50.
2005: Aileen dela Peña; Isabelle Leclercq; Jacqueline Field; Jacob George; Brett Jones; Geoffrey Farrell
NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis.
Gastroenterology 2005;129(5):1663-74.
2005: Peter Stärkel; Christine De Saeger; Isabelle Leclercq; Alastair Strain; yves horsmans
Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis.
Journal of hepatology 2005;43(4):687-95.
2005: Therese M Becker; Helen Rizos; A de la Pena; Isabelle Leclercq; Sarah Woodruff; Richard F Kefford; Graham J Mann
Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations.
Biochemical and biophysical research communications 2005;332(3):873-9.
2005: Peter Stärkel; Christine De Saeger; Christine Sempoux; Eric Legrand; Isabelle Leclercq; yves horsmans
Blunted DNA synthesis and delayed S-phase entry following inhibition of Cdk2 activity in the regenerating rat liver.
Laboratory investigation; a journal of technical methods and pathology 2005;85(4):562-71.
2005: Stéphanie Laurent; Peter Stärkel; Isabelle Leclercq; Luc Lambotte; DM Maiter; yves horsmans
Molecular events associated with accelerated proliferative response in rat livers when partial hepatectomy is preceded by a sham operation.
European journal of clinical investigation 2005;35(2):140-7.
2004: Isabelle Leclercq; Geoffrey C Farrell; Christine Sempoux; Aileen dela Peña; yves horsmans
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.
Journal of hepatology 2004;41(6):926-34.
2004: Emilia Ip; Geoffrey Farrell; Pauline Hall; Graham Robertson; Isabelle Leclercq
Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice.
Hepatology (Baltimore, Md.) 2004;39(5):1286-96.
2004: Isabelle Leclercq
Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis?
Clinical science (London, England : 1979) 2004;106(3):235-7.
2003: Jacob George; Natasha Pera; Nghi Phung; Isabelle Leclercq; Jing Yun Hou; Geoffrey Farrell
Lipid peroxidation, stellate cell activation and hepatic fibrogenesis in a rat model of chronic steatohepatitis.
Journal of hepatology 2003;39(5):756-64.
2003: Peter Stärkel; Christine Sempoux; Isabelle Leclercq; Michel Herin; C Deby; Jean-Pierre Desager; yves horsmans
Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats.
Journal of hepatology 2003;39(4):538-46.
2003: Emilia Ip; Geoffrey C Farrell; Graham Robertson; Pauline Hall; Richard Kirsch; Isabelle Leclercq
Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
Hepatology (Baltimore, Md.) 2003;38(1):123-32.
2003: Isabelle Leclercq; Jacqueline Field; Geoffrey C Farrell
Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury.
Gastroenterology 2003;124(5):1451-64.
2003: Narci Teoh; Isabelle Leclercq; Aileen Dela Pena; Geoffrey Farrell
Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning.
Hepatology (Baltimore, Md.) 2003;37(1):118-28.
2002: Isabelle Leclercq; Geoffrey C Farrell; Rixt Schriemer; Graham R Robertson
Leptin is essential for the hepatic fibrogenic response to chronic liver injury.
Journal of hepatology 2002;37(2):206-13.
2002: Geoffrey C Farrell; Graham R Robertson; Isabelle Leclercq; yves horsmans
Liver regeneration in obese mice with fatty livers: does the impairment have relevance for other types of fatty liver disease?
Hepatology (Baltimore, Md.) 2002;35(3):731-2.
2001: Graham Robertson; Isabelle Leclercq; Geoffrey C Farrell
Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(5):G1135-9.
2000: Luc Lambotte; B Li; Isabelle Leclercq; Christine Sempoux; Alain Saliez; yves horsmans
The compensatory hyperplasia (liver regeneration) following ligation of a portal branch is initiated before the atrophy of the deprived lobes.
Journal of hepatology 2000;32(6):940-5.
2000: Isabelle Leclercq; Geoffrey C Farrell; Jacqueline Field; D R Bell; F J Gonzalez; Graham R Robertson
CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis.
The Journal of clinical investigation 2000;105(8):1067-75.
2000: Isabelle Leclercq; Jacqueline Field; A Enriquez; Geoffrey C Farrell; Graham R Robertson
Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice.
Biochemical and biophysical research communications 2000;268(2):337-44.
1999: Isabelle Leclercq; yves horsmans; Jean-Pierre Desager; S Pauwels; André P Geubel
Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity.
The British journal of nutrition 1999;82(4):257-62.
1999: A Enriquez; Isabelle Leclercq; Geoffrey C Farrell; Graham Robertson
Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.
Biochemical and biophysical research communications 1999;255(2):300-6.
1999: Isabelle Leclercq; yves horsmans; M De Bruyere; André P Geubel
Influence of body mass index, sex and age on serum alanine aminotransferase (ALT) level in healthy blood donors.
Acta gastro-enterologica Belgica 1999;62(1):16-20.
1998: Isabelle Leclercq; yves horsmans; Jean-Pierre Desager
Estimation of chlorzoxazone hydroxylase activity in liver microsomes and of the plasma pharmacokinetics of chlorzoxazone by the same high-performance liquid chromatographic method.
Journal of chromatography. A 1998;828(1-2):291-6.
1998: Isabelle Leclercq; Jean-Pierre Desager; yves horsmans
Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress.
Clinical pharmacology and therapeutics 1998;64(2):144-9.
1998: Isabelle Leclercq; yves horsmans; Jean-Pierre Desager; N Delzenne; André P Geubel
Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation.
Journal of hepatology 1998;28(3):410-6.
1997: Isabelle Leclercq; Alain Saliez; P E Wallemacq; yves horsmans; Luc Lambotte
The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat.
Hepatology (Baltimore, Md.) 1997;26(5):1182-8.
1996: Isabelle Leclercq; Jean-Pierre Desager; C Vandenplas; yves horsmans
Fast determination of low-level cytochrome P-450 1A1 activity by high-performance liquid chromatography with fluorescence or visible absorbance detection.
Journal of chromatography. B, Biomedical applications 1996;681(2):227-32.