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Miles Houslay

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Ryan T Cameron; Ryan G Coleman; Jon P Day; Miles D Houslay; Brian K Shoichet; Krishna C Yalla; David R Adams; George S Baillie
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Natacha Le Moan; Frank Christian; Daniel M Houslay; Miles D Houslay; Katerina Akassoglou
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

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2013: Ryan T Cameron; Ryan G Coleman; Jon P Day; Miles D Houslay; Brian K Shoichet; Krishna C Yalla; David R Adams; George S Baillie
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).
Biochemical pharmacology 2013;85(9):1297-305.
2013: Kim M Brown; Frank Christian; Shireen A Davies; Jon P Day; Kornelia Hampel; Miles D Houslay; Elaine Huston; Walter Kolch; Louisa C Y Lee; David B Morton; David Romano; Masami Shimizu-Albergine; Selim Terhzaz; Miranda J Willis; Bastian Zimmermann; Joseph A Beavo; George S Baillie
Phosphodiesterase-8A binds to and regulates Raf-1 kinase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1533-42.
2011: Natacha Le Moan; Frank Christian; Daniel M Houslay; Miles D Houslay; Katerina Akassoglou
Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.
Molecular cell 2011;44(3):476-90.
2011: Miles D Houslay
Arresting times for PTEN.
The EMBO journal 2011;30(13):2513-5.
2011: Hannah Murdoch; James C Norman; Anke Prinz; Suryakiran Vadrevu; Graeme B Bolger; Allan J Dunlop; Enno Klussmann; Miles D Houslay
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.
Journal of cell science 2011;124(Pt 13):2253-66.
2011: Jonathan P Day; Barbara Lindsay; Tracy Riddell; Zhong Jiang; Robert W Allcock; Achamma Abraham; Sebastian Sookup; Frank Christian; Jana Bogum; Elisabeth K Martin; Robert L Rae; Diana Anthony; Georgina M Rosair; Daniel M Houslay; Elaine Huston; George S Baillie; Enno Klussmann; Miles D Houslay; David R Adams
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).
Journal of medicinal chemistry 2011;54(9):3331-47.
2011: Lindsay S Wilson; George S Baillie; Lisa M Pritchard; Bibiana Umana; Anna Terrin; Manuela Zaccolo; Miles D Houslay; Donald H Maurice
A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
The Journal of biological chemistry 2011;286(18):16285-96.
2011: Koko Ishizuka; Atsushi Kamiya; Edwin C Oh; Hiroaki Kanki; Saurav Seshadri; Jon F Robinson; Hannah Murdoch; Allan J Dunlop; Ken-ichiro Kubo; Keiko Furukori; Beverly Huang; Mariela Zeledon; Akiko Hayashi-Takagi; Hideyuki Okano; Kazunori Nakajima; Miles D Houslay; Nicholas Katsanis; Akira Sawa
DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.
Nature 2011;473(7345):92-6.
2011: Y Y Sin; H V Edwards; Xiang Li; Jonathan P Day; F Christian; Allan J Dunlop; David R Adams; Manuela Zaccolo; Miles D Houslay; George S Baillie
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Journal of molecular and cellular cardiology 2011;50(5):872-83.
2011: Kirsty F MacKenzie; Derek A Wallace; Elaine V Hill; Diana F Anthony; David J P Henderson; Daniel M Houslay; J Simon C Arthur; George S Baillie; Miles D Houslay
Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.
The Biochemical journal 2011;435(3):755-69.
2011: Alessia Perino; Alessandra Ghigo; Enrico Ferrero; Fulvio Morello; Gaetano Santulli; George S Baillie; Federico Damilano; Allan J Dunlop; Catherine Pawson; Romy Walser; Renzo Levi; Fiorella Altruda; Lorenzo Silengo; Lorene K Langeberg; Gitte Neubauer; Stephane Heymans; Giuseppe Lembo; Matthias P Wymann; Reinhard Wetzker; Miles D Houslay; Guido Iaccarino; John D Scott; Emilio Hirsch
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Molecular cell 2011;42(1):84-95.
2011: D F Anthony; Y Y Sin; S Vadrevu; N Advant; J P Day; A M Byrne; M J Lynch; Graeme Milligan; Miles D Houslay; George S Baillie
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.
Molecular and cellular biology 2011;31(5):1066-75.
2011: Miles D Houslay
Hard times for oncogenic BRAF-expressing melanoma cells.
Cancer cell 2011;19(1):3-4.
2011: Miles D Houslay; Marco Conti; Sharron H Fancis
The cyclic nucleotides.
Handbook of experimental pharmacology 2011;(204):v-vii.
2011: Sharron H Francis; Miles D Houslay; Marco Conti
Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action.
Handbook of experimental pharmacology 2011;(204):47-84.
2010: Peter Burton; David R Adams; Achamma Abraham; Robert W Allcock; Zhong Jiang; Angela McCahill; Jane Gilmour; John McAbney; Alexandra Kaupisch; Nicole Kane; George S Baillie; Andrew H Baker; Graeme Milligan; Miles D Houslay; joanne mountford
Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.
The Biochemical journal 2010;432(3):575-84.
2010: Nicole Kane; Ali Nowrouzi; Sayandip Mukherjee; Michael P Blundell; Jenny A Greig; Wai Kwong Lee; Miles D Houslay; Graeme Milligan; joanne mountford; Christof von Kalle; Manfred Schmidt; Adrian J Thrasher; Andrew H Baker
Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(12):2139-45.
2010: Paul D Andrews; Melissa Becroft; Anders Aspegren; Jane Gilmour; Martyn J James; Scott McRae; Robert Kime; Robert W Allcock; Achamma Abraham; Zhong Jiang; Raimund Strehl; Joanne C Mountford; Graeme Milligan; Miles D Houslay; David R Adams; Julie A Frearson
High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.
The Biochemical journal 2010;432(1):21-33.
2010: Miles D Houslay; Frank Christian
p62 (SQSTM1) forms part of a novel, reversible aggregate containing a specific conformer of the cAMP degrading phosphodiesterase, PDE4A4.
Autophagy 2010;6(8):1198-200.
2010: Hyun Wook Kim; Sang Hoon Ha; Mi Nam Lee; Elaine Huston; Do-Hyung Kim; Sung Key Jang; Pann-Ghill Suh; Miles D Houslay; Sung Ho Ryu
Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.
Molecular and cellular biology 2010;30(22):5406-20.
2010: Sarah N Rampersad; Jeffrey D Ovens; Elaine Huston; M Bibiana Umana; Lindsay S Wilson; Stuart J Netherton; Martin J Lynch; George S Baillie; Miles D Houslay; Donald H Maurice
Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability.
The Journal of biological chemistry 2010;285(44):33614-22.
2010: Frank Christian; Diana F Anthony; Surakiran Vadrevu; Tracy Riddell; Jonathan P Day; Ruth McLeod; David R Adams; George S Baillie; Miles D Houslay
p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.
Cellular signalling 2010;22(10):1576-96.
2010: Hong Zhu; Hee Yun Suk; Raymond Y L Yu; Deborah Brancho; Opeyemi Olabisi; Teddy T C Yang; XiaoYong Yang; Jialin Zhang; Mustapha Moussaif; Jorge L Durand; Linda Jelicks; Ja-Young Kim; Philipp E Scherer; Philippe G Frank; Michael P Lisanti; John W Calvert; Mark R Duranski; David J Lefer; Elaine Huston; George S Baillie; Miles D Houslay; Jeffrey D Molkentin; Jianping Jin; Chi-Wing Chow
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
Molecular and cellular biology 2010;30(18):4379-90.
2010: Peter Burton; David R Adams; Achamma Abraham; Robert W Allcock; Zhong Jiang; Angela McCahill; Jane Gilmour; John McAbney; Nicole Kane; George S Baillie; Fergus R McKenzie; Andrew H Baker; Miles D Houslay; joanne mountford; Graeme Milligan
Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.
Biochemical Society transactions 2010;38(4):1058-61.
2010: Nicole Kane; Marco Meloni; Helen L Spencer; Margaret A Craig; Raimund Strehl; Graeme Milligan; Miles D Houslay; joanne mountford; Costanza Emanueli; Andrew H Baker
Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(7):1389-97.
2010: Bryan Serrels; Emma Sandilands; Alan Serrels; George Baillie; Miles D Houslay; Valerie G Brunton; Marta Canel; Laura M Machesky; Kurt I Anderson; Margaret C Frame
A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.
Current biology : CB 2010;20(12):1086-92.
2010: Xiang Li; Suryakiran Vadrevu; Allan J Dunlop; Jon Day; Noopur Advant; Jessica Troeger; Enno Klussmann; Ellis Jaffrey; Ron Thomas Hay; David R Adams; Miles D Houslay; George S Baillie
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
The Biochemical journal 2010;428(1):55-65.
2010: Michele P Kelly; Sheree F Logue; Julie Brennan; Jonathon P Day; Subha Lakkaraju; Lixin Jiang; Xiaotian Zhong; May Tam; Stacey J Sukoff Rizzo; Brian J Platt; Jason M Dwyer; Sarah Neal; Virginia L Pulito; Michael J Agostino; Steven M Grauer; Rachel L Navarra; Cody Kelley; thomas Comery; Richard J Murrills; Miles D Houslay; Nicholas J Brandon
Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8457-62.
2010: Elisa Bjørgo; Silje A Solheim; Hilde Abrahamsen; George S Baillie; Kim M Brown; Torunn Berge; Klaus Okkenhaug; Miles D Houslay; Kjetil Taskén
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.
Molecular and cellular biology 2010;30(7):1660-72.
2010: Akiko Hayashi-Takagi; Manabu Takaki; Nick Graziane; Saurav Seshadri; Hannah Murdoch; Allan J Dunlop; Yuichi Makino; Anupamaa J Seshadri; Koko Ishizuka; Deepak P Srivastava; Zhong Xie; Jay M Baraban; Miles D Houslay; Toshifumi Tomoda; Nicholas J Brandon; Atsushi Kamiya; Zhen Yan; Peter Penzes; Akira Sawa
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.
Nature neuroscience 2010;13(3):327-32.
2010: Miles D Houslay
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown.
Trends in biochemical sciences 2010;35(2):91-100.
2010: Tian-Rui Xu; Vladislav Vyshemirsky; Amélie Gormand; Alex von Kriegsheim; Mark Girolami; George S Baillie; Dominic Ketley; Allan J Dunlop; Graeme Milligan; Miles D Houslay; Walter Kolch
Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.
Science signaling 2010;3(134):ra20.
2010: Tian-Rui Xu; Vladislav Vyshemirsky; Amélie Gormand; Alex von Kriegsheim; Mark Girolami; George S Baillie; Dominic Ketley; Allan J Dunlop; Graeme Milligan; Miles D Houslay; Walter Kolch
Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species.
Science signaling 2010;3(113):ra20.
2010: Miles D Houslay; David R Adams
Putting the lid on phosphodiesterase 4.
Nature biotechnology 2010;28(1):38-40.
2009: Christopher G Vecsey; George S Baillie; Devan Jaganath; Robbert Havekes; Andrew Daniels; Mathieu Wimmer; Ted Huang; Kim M Brown; Xiang-Yao Li; Giannina Descalzi; Susan S Kim; Tao Chen; Yu-Ze Shang; Min Zhuo; Miles D Houslay; Ted Abel
Sleep deprivation impairs cAMP signalling in the hippocampus.
Nature 2009;461(7267):1122-5.
2009: Xiang Li; Ruth MacLeod; Allan J Dunlop; Helen V Edwards; Noopur Advant; Lucien C D Gibson; Nicola M Devine; Kim M Brown; David R Adams; Miles D Houslay; George S Baillie
A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
FEBS letters 2009;583(20):3310-6.
2009: Miles D Houslay
Disrupting specific PDZ domain-mediated interactions for therapeutic benefit.
British journal of pharmacology 2009;158(2):483-5.
2009: Patrick A Kiely; George S Baillie; Robert Barrett; Deirdre Buckley; David R Adams; Miles D Houslay; Rosemary O'Connor
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
The Journal of biological chemistry 2009;284(30):20263-74.
2009: Xiang Li; George S Baillie; Miles D Houslay
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
The Journal of biological chemistry 2009;284(24):16170-82.
2009: Wee Kiat Ong; F M Gribble; F Reimann; M J Lynch; Miles D Houslay; G S Baillie; Brian L Furman; Nigel J Pyne
The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release.
British journal of pharmacology 2009;157(4):633-44.
2009: Dong Meng; Martin J Lynch; Elaine Huston; Michael Beyermann; Jenny Eichhorst; David R Adams; Enno Klussmann; Enno Klusmann; Miles D Houslay; George S Baillie
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
The Journal of biological chemistry 2009;284(17):11425-35.
2009: Cecile Terrenoire; Miles D Houslay; George S Baillie; Robert Kass
The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.
The Journal of biological chemistry 2009;284(14):9140-6.
2009: Miles D Houslay
Arrestin times for developing antipsychotics and beta-blockers.
Science signaling 2009;2(66):pe22.
2008: Daniel M Collins; Hannah Murdoch; Allan J Dunlop; Erik Charych; George S Baillie; Qi Wang; Friedrich W Herberg; Nicholas Brandon; Anke Prinz; Miles D Houslay
Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).
Cellular signalling 2008;20(12):2356-69.
2008: Angela McCahill; Lachlan Campbell; Theresa McSorley; Arvind Sood; Martin J Lynch; Xiang Li; Chen Yan; George S Baillie; Miles D Houslay
In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).
Cellular signalling 2008;20(11):2071-83.
2008: Giulietta Di Benedetto; Anna Zoccarato; Valentina Lissandron; Anna Terrin; Xiang Li; Miles D Houslay; George S Baillie; Manuela Zaccolo
Protein kinase A type I and type II define distinct intracellular signaling compartments.
Circulation research 2008;103(8):836-44.
2008: Jonathan P Day; Vaughn Cleghon; Miles D Houslay; Shireen A Davies
Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.
The Biochemical journal 2008;414(3):363-74.
2008: Elaine Huston; Martin J Lynch; Ahmed Mohamed; Daniel M Collins; Elaine V Hill; Ruth MacLeod; Eberhard Krause; George S Baillie; Miles D Houslay
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12791-6.
2008: Patrick A Kiely; George S Baillie; Martin J Lynch; Miles D Houslay; Rosemary O'Connor
Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.
The Journal of biological chemistry 2008;283(34):22952-61.
2008: Tian-Rui Xu; George S Baillie; Narinder Bhari; Thomas M Houslay; Andrew M Pitt; David R Adams; Walter Kolch; Miles D Houslay; Graeme Milligan
Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.
The Biochemical journal 2008;413(1):51-60.
2008: Kirsty F Mackenzie; Emma C Topping; Bozena Bugaj-Gaweda; Chengjun Deng; York-Fong Cheung; Aileen E Olsen; Cecil R Stockard; Lisa High Mitchell; George S Baillie; William E Grizzle; Michael De Vivo; Miles D Houslay; Daguang Wang; Graeme B Bolger
Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.
The Biochemical journal 2008;411(2):361-9.
2008: Matthew D Cullen; York-Fong Cheung; Miles D Houslay; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(4):1530-3.
2008: Michele P Kelly; York-Fong Cheung; Christopher Favilla; Steven J Siegel; Stephen J Kanes; Miles D Houslay; Ted Abel
Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(2):75-83.
2008: A C McCahill; Elaine Huston; Xiang Li; Miles D Houslay
PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases.
Handbook of experimental pharmacology 2008;(186):125-66.
2007: K John Smith; George S Baillie; Eva I Hyde; Xiang Li; Thomas M Houslay; Angela McCahill; Allan J Dunlop; Graeme B Bolger; Enno Klussmann; David R Adams; Miles D Houslay
1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1.
Cellular signalling 2007;19(12):2612-24.
2007: Huanchen Wang; Ming-Sheng Peng; Yi Chen; Jie Geng; Howard Robinson; Miles D Houslay; Jiwen Cai; Hengming Ke
Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
The Biochemical journal 2007;408(2):193-201.
2007: Debbie Willoughby; George S Baillie; Martin J Lynch; Antonio Ciruela; Miles D Houslay; dermot cooper
Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling.
The Journal of biological chemistry 2007;282(47):34235-49.
2007: Martin J Lynch; George S Baillie; Miles D Houslay
cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.
Biochemical Society transactions 2007;35(Pt 5):938-41.
2007: J Kirsty Millar; Shaun Mackie; Steven J Clapcote; Hannah Murdoch; Ben S Pickard; Sheila Christie; Walter J Muir; D H R Blackwood; John C Roder; Miles D Houslay; David J Porteous
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness.
The Journal of physiology 2007;584(Pt 2):401-5.
2007: Hannah Murdoch; Shaun Mackie; Daniel M Collins; Elaine V Hill; Graeme B Bolger; Enno Klussmann; David J Porteous; J Kirsty Millar; Miles D Houslay
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(35):9513-24.
2007: York-Fong Cheung; Zhengyan Kan; Philip Garrett-Engele; Irene Gall; Hannah Murdoch; George S Baillie; L Miguel Camargo; Jason Johnson; Miles D Houslay; John Castle
PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).
The Journal of pharmacology and experimental therapeutics 2007;322(2):600-9.
2007: Benjamin D Sachs; George S Baillie; Julianne R McCall; Melissa A Passino; Christian Schachtrup; Derek A Wallace; Allan J Dunlop; Kirsty F MacKenzie; Enno Klussmann; Martin J Lynch; Shoana L Sikorski; Tal Nuriel; Igor Tsigelny; Jin Zhang; Miles D Houslay; Moses V Chao; Katerina Akassoglou
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.
The Journal of cell biology 2007;177(6):1119-32.
2007: David G McEwan; Valerie G Brunton; George S Baillie; Nicholas R Leslie; Miles D Houslay; Margaret C Frame
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Cancer research 2007;67(11):5248-57.
2007: George S Baillie; David R Adams; Narinder Bhari; Thomas M Houslay; Suryakiran Vadrevu; Dong Meng; Xiang Li; Allan J Dunlop; Graeme Milligan; Graeme B Bolger; Enno Klussmann; Miles D Houslay
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
The Biochemical journal 2007;404(1):71-80.
2007: Steven J Clapcote; Tatiana Lipina; J Kirsty Millar; Shaun Mackie; Sheila Christie; Fumiaki Ogawa; Jason P Lerch; Keith Trimble; Masashi Uchiyama; Yoshiyuki Sakuraba; Hideki Kaneda; Toshihiko Shiroishi; Miles D Houslay; R Mark Henkelman; John G Sled; Yoichi Gondo; David J Porteous; John C Roder
Behavioral phenotypes of Disc1 missense mutations in mice.
Neuron 2007;54(3):387-402.
2007: Miles D Houslay; George S Baillie; Donald H Maurice
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling.
Circulation research 2007;100(7):950-66.
2007: Michele P Kelly; Carolina Isiegas; York-Fong Cheung; Jan Tokarczyk; Xioaju Yang; Michael F Esposito; David A Rapoport; Sara A Fabian; Steven J Siegel; Gary S Wand; Miles D Houslay; Stephen J Kanes; Ted Abel
Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(3):577-88.
2007: Eduard Stefan; Burkhard Wiesner; George S Baillie; Rustam Mollajew; Volker Henn; Dorothea Lorenz; Jens Furkert; Katja Santamaria; Pavel I Nedvetsky; Christian Hundsrucker; Michael Beyermann; Eberhard Krause; Peter Pohl; Irene Gall; Andrew N MacIntyre; Sebastian Bachmann; Miles D Houslay; Walter Rosenthal; Enno Klussmann
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.
Journal of the American Society of Nephrology : JASN 2007;18(1):199-212.
2006: Anna Terrin; Giulietta Di Benedetto; Vanessa Pertegato; York-Fong Cheung; George S Baillie; Martin J Lynch; Nicola Elvassore; Anke Prinz; Friedrich W Herberg; Miles D Houslay; Manuela Zaccolo
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
The Journal of cell biology 2006;175(3):441-51.
2006: Elaine V Hill; Catherine L Sheppard; York-Fong Cheung; Irene Gall; Eberhard Krause; Miles D Houslay
Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.
Cellular signalling 2006;18(11):2056-69.
2006: Elaine Huston; Irene Gall; Thomas M Houslay; Miles D Houslay
Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.
Journal of cell science 2006;119(Pt 18):3799-810.
2006: Stefanos A Kalamidas; Mark Kuehnel; Pascale Peyron; Vladimir Rybin; Susanne Rauch; Othon B Kotoulas; Miles D Houslay; Brian A Hemmings; Maximiliano Gutierrez; Elsa Anes; Gareth Griffiths
cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria.
Journal of cell science 2006;119(Pt 17):3686-94.
2006: Miles D Houslay
A RSK(y) relationship with promiscuous PKA.
Science's STKE : signal transduction knowledge environment 2006;2006(349):pe32.
2006: Graeme B Bolger; George S Baillie; Xiang Li; Martin J Lynch; Pawel Herzyk; Ahmed Mohamed; Lisa High Mitchell; Angela McCahill; Christian Hundsrucker; Enno Klussmann; David R Adams; Miles D Houslay
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.
The Biochemical journal 2006;398(1):23-36.
2006: Elaine Huston; Thomas M Houslay; George S Baillie; Miles D Houslay
cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.
Biochemical Society transactions 2006;34(Pt 4):504-9.
2006: Miles D Houslay; George S Baillie
Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation.
Biochemical Society transactions 2006;34(Pt 4):474-5.
2006: Line M Grønning; George S Baillie; Anna Cederberg; Martin J Lynch; Miles D Houslay; Sven Enerbäck; Kjetil Taskén
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice.
FEBS letters 2006;580(17):4126-30.
2006: Theresa McSorley; Eduard Stefan; Volker Henn; Burkhard Wiesner; George S Baillie; Miles D Houslay; Walter Rosenthal; Enno Klussmann
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells.
European journal of cell biology 2006;85(7):673-8.
2006: Jennifer Millen; Margaret R MacLean; Miles D Houslay
Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells.
European journal of cell biology 2006;85(7):679-91.
2006: Xiang Li; Elaine Huston; Martin J Lynch; Miles D Houslay; George S Baillie
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.
The Biochemical journal 2006;394(Pt 2):427-35.
2006: Marco Mongillo; Carlo G Tocchetti; Anna Terrin; Valentina Lissandron; York-Fong Cheung; Wolfgang R Dostmann; Tullio Pozzan; David A Kass; Nazareno Paolocci; Miles D Houslay; Manuela Zaccolo
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Circulation research 2006;98(2):226-34.
2006: Jonathan P Day; Miles D Houslay; Shireen A Davies
A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP.
The Biochemical journal 2006;393(Pt 2):481-8.
2006: Martin J Lynch; Elaine V Hill; Miles D Houslay
Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling.
Current topics in developmental biology 2006;75():225-59.
2005: Miles D Houslay; George S Baillie
Beta-arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of beta2-adrenoceptor signalling to activation of ERK.
Biochemical Society transactions 2005;33(Pt 6):1333-6.
2005: Volker Henn; Eduard Stefan; George S Baillie; Miles D Houslay; Walter Rosenthal; Enno Klussmann
Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.
Biochemical Society transactions 2005;33(Pt 6):1316-8.
2005: J Kirsty Millar; Ben S Pickard; Shaun Mackie; Rachel James; Sheila Christie; Sebastienne R Buchanan; M Pat Malloy; Jennifer E Chubb; Elaine Huston; George S Baillie; Pippa A Thomson; Elaine V Hill; Nicholas J Brandon; Jean-Christophe Rain; L Miguel Camargo; Paul J Whiting; Miles D Houslay; D H R Blackwood; Walter J Muir; David J Porteous
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science (New York, N.Y.) 2005;310(5751):1187-91.
2005: Miles D Houslay; Peter Schafer; Kam Y J Zhang
Keynote review: phosphodiesterase-4 as a therapeutic target.
Drug discovery today 2005;10(22):1503-19.
2005: Martin J Lynch; George S Baillie; Ahmed Mohamed; Xiang Li; Charlotte Maisonneuve; Enno Klussmann; Gino van Heeke; Miles D Houslay
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
The Journal of biological chemistry 2005;280(39):33178-89.
2005: Miles D Houslay
The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target.
Molecular pharmacology 2005;68(3):563-7.
2005: Angela McCahill; Theresa McSorley; Elaine Huston; Elaine V Hill; Martin J Lynch; Irene Gall; Guy Keryer; Birgitte Lygren; Kjetil Tasken; Gino van Heeke; Miles D Houslay
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
Cellular signalling 2005;17(9):1158-73.
2005: George S Baillie; John D Scott; Miles D Houslay
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract.
FEBS letters 2005;579(15):3264-70.
2005: Derek A Wallace; Lee Ann Johnston; Elaine Huston; Douglas MacMaster; Thomas M Houslay; York-Fong Cheung; Lachlan Campbell; Jennifer Millen; Robin A Smith; Irene Gall; Richard G Knowles; Michael Sullivan; Miles D Houslay
Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
Molecular pharmacology 2005;67(6):1920-34.
2005: Jonathan P Day; Julian Dow; Miles D Houslay; Shireen A Davies
Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.
The Biochemical journal 2005;388(Pt 1):333-42.
2005: George S Baillie; Miles D Houslay
Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes.
Current opinion in cell biology 2005;17(2):129-34.
2005: Elaine V Hill; Miles D Houslay; George S Baillie
Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases.
Methods in molecular biology (Clifton, N.J.) 2005;307():225-37.
2004: Hilde Abrahamsen; George S Baillie; Jacob Ngai; Torkel Vang; Konstantina Nika; Anja Ruppelt; Tomas Mustelin; Manuela Zaccolo; Miles D Houslay; Kjetil Taskén
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):4847-58.
2004: Rachael Barber; George S Baillie; Reinhard Bergmann; Malcolm C Shepherd; Ruth Sepper; Miles D Houslay; Gino Van Heeke
Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers.
American journal of physiology. Lung cellular and molecular physiology 2004;287(2):L332-43.
2004: Marco Mongillo; Theresa McSorley; Sandrine Evellin; Arvind Sood; Valentina Lissandron; Anna Terrin; Elaine Huston; Annette Hannawacker; Martin J Lohse; Tullio Pozzan; Miles D Houslay; Manuela Zaccolo
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Circulation research 2004;95(1):67-75.
2004: Matthew R MacPherson; Kate E Broderick; Shirley Graham; Jonathan P Day; Miles D Houslay; Julian Dow; Shireen A Davies
The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase.
The Journal of experimental biology 2004;207(Pt 16):2769-76.
2004: Lee Ann Johnston; Suat Erdogan; York-Fong Cheung; Michael Sullivan; Rachael Barber; Martin J Lynch; George S Baillie; Gino van Heeke; David R Adams; Elaine Huston; Miles D Houslay
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.
The Biochemical journal 2004;380(Pt 2):371-84.
2004: Yvonne M Fleming; Margaret C Frame; Miles D Houslay
PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration.
Journal of cell science 2004;117(Pt 11):2377-88.
2004: Malcolm C Shepherd; George S Baillie; David I Stirling; Miles D Houslay
Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.
British journal of pharmacology 2004;142(2):339-51.
2003: Graeme B Bolger; Angela McCahill; Elaine Huston; York-Fong Cheung; Theresa McSorley; George S Baillie; Miles D Houslay
The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.
The Journal of biological chemistry 2003;278(49):49230-8.
2003: Miles D Houslay; George S Baillie
The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.
Biochemical Society transactions 2003;31(Pt 6):1186-90.
2003: Robert Terry; York-Fong Cheung; Morten Praestegaard; George S Baillie; Elaine Huston; Irene Gall; David R Adams; Miles D Houslay
Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.
Cellular signalling 2003;15(10):955-71.
2003: Graeme B Bolger; Alexander H Peden; Michael R Steele; Carolynn MacKenzie; David G McEwan; Derek A Wallace; Elaine Huston; George S Baillie; Miles D Houslay
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2.
The Journal of biological chemistry 2003;278(35):33351-63.
2003: Mhairi J Frame; Rothwelle Tate; David R Adams; Keith M Morgan; Miles D Houslay; Peter Vandenabeele; Nigel J Pyne
Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1).
European journal of biochemistry / FEBS 2003;270(5):962-70.
2003: Malcolm Shepherd; Theresa McSorley; Aileen E Olsen; Lee Ann Johnston; Neil C Thomson; George S Baillie; Miles D Houslay; Graeme B Bolger
Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.
The Biochemical journal 2003;370(Pt 2):429-38.
2003: Miles D Houslay; David R Adams
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.
The Biochemical journal 2003;370(Pt 1):1-18.
2003: George S Baillie; Arvind Sood; Ian McPhee; Irene Gall; Stephen J Perry; Robert J Lefkowitz; Miles D Houslay
beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):940-5.
2002: Angela McCahill; Jim Warwicker; Graeme B Bolger; Miles D Houslay; Stephen J Yarwood
The RACK1 scaffold protein: a dynamic cog in cell response mechanisms.
Molecular pharmacology 2002;62(6):1261-73.
2002: Stephen J Perry; George S Baillie; Trudy A Kohout; Ian McPhee; Maria M Magiera; Kok Long Ang; William E Miller; Alison J McLean; Marco Conti; Miles D Houslay; Robert J Lefkowitz
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins.
Science (New York, N.Y.) 2002;298(5594):834-6.
2002: Ivan R Le Jeune; Malcolm Shepherd; Gino van Heeke; Miles D Houslay; Ian P Hall
Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter.
The Journal of biological chemistry 2002;277(39):35980-9.
2002: George S Baillie; Elaine Huston; Grant Scotland; Matthew N Hodgkin; Irene Gall; Alexander H Peden; Carolynn MacKenzie; Emma S Houslay; Richard Currie; Trevor R Pettitt; Adrian R Walmsley; Michael J O Wakelam; Jim Warwicker; Miles D Houslay
TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.
The Journal of biological chemistry 2002;277(31):28298-309.
2002: Simon MacKenzie; George S Baillie; Ian McPhee; Carolynn MacKenzie; Rachael Seamons; Theresa McSorley; Jennifer Millen; Matthew B Beard; Gino van Heeke; Miles D Houslay
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
British journal of pharmacology 2002;136(3):421-33.
2002: Matthew B Beard; Elaine Huston; Lachlan Campbell; Irene Gall; Ian McPhee; Stephen J Yarwood; Grant Scotland; Miles D Houslay
In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.
Cellular signalling 2002;14(5):453-65.
2002: Zaruhi Poghosyan; Stephen M Robbins; Miles D Houslay; Ailsa Webster; Gillian Murphy; Dylan R Edwards
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
The Journal of biological chemistry 2002;277(7):4999-5007.
2002: Graeme B Bolger; Angela McCahill; Stephen J Yarwood; Michael R Steele; Jim Warwicker; Miles D Houslay
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5.
BMC biochemistry 2002;3():24.
2001: Ian McPhee; S Cochran; Miles D Houslay
The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms.
Cellular signalling 2001;13(12):911-8.
2001: MM Makhay; Miles D Houslay; James Michael O'Donnell
Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats.
Psychopharmacology 2001;158(3):297-304.
2001: George S Baillie; Simon MacKenzie; Miles D Houslay
Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).
Molecular pharmacology 2001;60(5):1100-11.
2001: Y Ye; K Jackson; Miles D Houslay; L Judson Chandler; James Michael O'Donnell
Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures.
Brain research. Developmental brain research 2001;130(1):115-21.
2001: Karl J Staples; M Bergmann; K Tomita; Miles D Houslay; I McPhee; Peter J Barnes; Mark A Giembycz; Robert Newton
Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):2074-80.
2001: Michael R Steele; Angela McCahill; D S Thompson; Carolynn MacKenzie; N W Isaacs; Miles D Houslay; Graeme B Bolger
Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5.
Cellular signalling 2001;13(7):507-13.
2001: SM Farooqui; F Al-Bagdadi; Miles D Houslay; G B Bolger; R Stout; R D Specian; J A Cherry; M Conti; James Michael O'Donnell
Surgically induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic adenosine monophosphate-dependent phosphodiesterases type 4 in abdominal testes of rats.
Biology of reproduction 2001;64(6):1583-9.
2001: G Rena; F Begg; A Ross; Carolynn MacKenzie; Ian McPhee; Lachlan Campbell; Elaine Huston; Michael Sullivan; Miles D Houslay
Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.
Molecular pharmacology 2001;59(5):996-1011.
2001: Kimberly L Dodge; S Khouangsathiene; Michael Kapiloff; R Mouton; E V Hill; Miles D Houslay; Lorene K Langeberg; John D Scott
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.
The EMBO journal 2001;20(8):1921-30.
2001: Miles D Houslay
PDE4 cAMP-specific phosphodiesterases.
Progress in nucleic acid research and molecular biology 2001;69():249-315.
2000: Yasmin Shakur; Kazuyo Takeda; Y Kenan; Zu-Xi Yu; G Rena; D Brandt; Miles D Houslay; Eva Degerman; Victor J Ferrans; Vincent C Manganiello
Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.
The Journal of biological chemistry 2000;275(49):38749-61.
2000: George S Baillie; Simon MacKenzie; Ian McPhee; Miles D Houslay
Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases.
British journal of pharmacology 2000;131(4):811-9.
2000: Miles D Houslay; W Kolch
Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling.
Molecular pharmacology 2000;58(4):659-68.
2000: Elaine Huston; Matthew B Beard; F McCallum; N J Pyne; P Vandenabeele; Grant Scotland; Miles D Houslay
The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution.
The Journal of biological chemistry 2000;275(36):28063-74.
2000: Ian McPhee; Miles D Houslay; Stephen J Yarwood
Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells.
FEBS letters 2000;477(3):213-8.
2000: Simon MacKenzie; George S Baillie; Ian McPhee; Graeme B Bolger; Miles D Houslay
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions.
The Journal of biological chemistry 2000;275(22):16609-17.
2000: Simon MacKenzie; Miles D Houslay
Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells.
The Biochemical journal 2000;347(Pt 2):571-8.
2000: Matthew B Beard; Aileen E Olsen; R E Jones; Suat Erdogan; Miles D Houslay; Graeme B Bolger
UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.
The Journal of biological chemistry 2000;275(14):10349-58.
1999: Matthew B Beard; J C O'Connell; Graeme B Bolger; Miles D Houslay
The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.
FEBS letters 1999;460(1):173-7.
1999: Michael Sullivan; A S Olsen; Miles D Houslay
Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.
Cellular signalling 1999;11(10):735-42.
1999: Stephen J Yarwood; Michael R Steele; Grant Scotland; Miles D Houslay; Graeme B Bolger
The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.
The Journal of biological chemistry 1999;274(21):14909-17.
1999: Ian McPhee; Stephen J Yarwood; Grant Scotland; Elaine Huston; Matthew B Beard; AH Ross; Emma S Houslay; Miles D Houslay
Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition.
The Journal of biological chemistry 1999;274(17):11796-810.
1999: Stephen J Yarwood; Elizabeth Sale; Graham J Sale; Miles D Houslay; E Kilgour; NG Anderson
Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling.
The Journal of biological chemistry 1999;274(13):8662-8.
1999: R Hoffmann; George S Baillie; Simon MacKenzie; Stephen J Yarwood; Miles D Houslay
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.
The EMBO journal 1999;18(4):893-903.
1998: R A Doris; E Kilgour; Miles D Houslay; Richard G Vernon
Regulation of the GTP-binding protein-based antilipolytic system of sheep adipocytes by growth hormone.
The Journal of endocrinology 1998;158(3):295-303.
1998: G Rena; Miles D Houslay
A simple method for sequencing small DNAs by introducing precise overlapping ends into restriction digestion fragments.
Nucleic acids research 1998;26(16):3867-8.
1998: I Fleming; Simon MacKenzie; Richard G Vernon; NG Anderson; Miles D Houslay; E Kilgour
Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation.
The Biochemical journal 1998;333 ( Pt 3)():719-27.
1998: Michael Sullivan; G Rena; F Begg; L Gordon; A S Olsen; Miles D Houslay
Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2.
The Biochemical journal 1998;333 ( Pt 3)():693-703.
1998: R Hoffmann; I R Wilkinson; J F McCallum; P Engels; Miles D Houslay
cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.
The Biochemical journal 1998;333 ( Pt 1)():139-49.
1998: Miles D Houslay
Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases.
Seminars in cell & developmental biology 1998;9(2):161-7.
1998: Simon MacKenzie; Stephen J Yarwood; Alexander H Peden; Graeme B Bolger; Richard G Vernon; Miles D Houslay
Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3549-54.
1998: Grant Scotland; Miles D Houslay
Molecular genetic approaches. III. Determination of protein sequence motifs involved in protein targeting by use of coupled transcription-translation systems.
Methods in molecular biology (Clifton, N.J.) 1998;88():141-50.
1998: Miles D Houslay; Michael Sullivan; Graeme B Bolger
The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions.
Advances in pharmacology (San Diego, Calif.) 1998;44():225-342.
1998: Alison M Michie; G Rena; M M Harnett; Miles D Houslay
Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases.
Cell biochemistry and biophysics 1998;28(2-3):161-85.
1998: Grant Scotland; Matthew B Beard; Suat Erdogan; Elaine Huston; F McCallum; Simon MacKenzie; Alexander H Peden; L Pooley; N G Rena; AH Ross; Stephen J Yarwood; Miles D Houslay
Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.
Methods (San Diego, Calif.) 1998;14(1):65-79.
1997: Y Ye; M Conti; Miles D Houslay; SM Farooqui; M Chen; James Michael O'Donnell
Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain.
Journal of neurochemistry 1997;69(6):2397-404.
1997: Elaine Huston; S Lumb; A Russell; C Catterall; AH Ross; Michael R Steele; Graeme B Bolger; Martin J Perry; RJ Owens; Miles D Houslay
Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.
The Biochemical journal 1997;328 ( Pt 2)():549-58.
1997: Graeme B Bolger; Suat Erdogan; R E Jones; K Loughney; Grant Scotland; R Hoffmann; I Wilkinson; C Farrell; Miles D Houslay
Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene.
The Biochemical journal 1997;328 ( Pt 2)():539-48.
1997: B Soret; S E Melrose; E Finley; Maureen T Travers; Miles D Houslay; Richard G Vernon
Development of lipid metabolism in ovine preadipocytes in vitro.
Biochemical Society transactions 1997;25(4):S671.
1997: I M Fleming; Simon MacKenzie; Miles D Houslay; Richard G Vernon; E Kilgour
Antisense technology reveals distinct roles for protein kinase C isoforms during 3T3-F442A preadipocyte differentiation.
Biochemical Society transactions 1997;25(4):S665.
1997: MM Kostic; Suat Erdogan; G Rena; G Borchert; Brigitte Hoch; Sabine Bartel; Grant Scotland; Elaine Huston; Miles D Houslay; Ernst-Georg Krause
Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart.
Journal of molecular and cellular cardiology 1997;29(11):3135-46.
1997: Margaret R MacLean; E D Johnston; KM Mcculloch; L Pooley; Miles D Houslay; G Sweeney
Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension.
The Journal of pharmacology and experimental therapeutics 1997;283(2):619-24.
1997: E S Tobias; E Rozengurt; J M Connell; Miles D Houslay
Co-transfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptors.
The Biochemical journal 1997;326 ( Pt 2)():545-51.
1997: Miles D Houslay; Graeme Milligan
Tailoring cAMP-signalling responses through isoform multiplicity.
Trends in biochemical sciences 1997;22(6):217-24.
1997: Simon MacKenzie; I Fleming; Miles D Houslay; NG Anderson; E Kilgour
Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells.
The Biochemical journal 1997;324 ( Pt 1)():159-65.
1997: I M Fleming; Simon MacKenzie; Miles D Houslay; E Kilgour
Protein kinase C isoform expression during differentiation of 3T3-F442A preadipocytes.
Biochemical Society transactions 1997;25(2):211S.
1997: Miles D Houslay; Grant Scotland; Suat Erdogan; Elaine Huston; Simon MacKenzie; J F McCallum; Ian McPhee; L Pooley; G Rena; A Ross; Matthew B Beard; A Peder; F Begg; I Wilkinson; Stephen J Yarwood; C Ackerman; Emma S Houslay; R Hoffman; P Engels; Michael Sullivan; Graeme B Bolger
Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.
Biochemical Society transactions 1997;25(2):374-81.
1997: D M Juilfs; H J Fülle; AZ Zhao; Miles D Houslay; David L Garbers; Joseph A Beavo
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3388-95.
1997: L Pooley; Yasmin Shakur; G Rena; Miles D Houslay
Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines.
The Biochemical journal 1997;321 ( Pt 1)():177-85.
1997: Suat Erdogan; Miles D Houslay
Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant.
The Biochemical journal 1997;321 ( Pt 1)():165-75.
1997: S Spence; G Rena; Michael Sullivan; Suat Erdogan; Miles D Houslay
Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.
The Biochemical journal 1997;321 ( Pt 1)():157-63.
1996: Elaine Huston; L Pooley; P Julien; Grant Scotland; Ian McPhee; Michael Sullivan; Graeme B Bolger; Miles D Houslay
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
The Journal of biological chemistry 1996;271(49):31334-44.
1996: Miles D Houslay
The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity.
Biochemical Society transactions 1996;24(4):980-6.
1996: Margaret R MacLean; G Sweeney; M Baird; KM Mcculloch; Miles D Houslay; Ian Morecroft
5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats.
British journal of pharmacology 1996;119(5):917-30.
1996: J C O'Connell; J F McCallum; Ian McPhee; J Wakefield; E S Houslay; W Wishart; Graeme B Bolger; M Frame; Miles D Houslay
The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).
The Biochemical journal 1996;318 ( Pt 1)():255-61.
1996: B A Van Tine; BY Azizeh; Dev Trivedi; J R Phelps; Miles D Houslay; D G Johnson; Victor J Hruby
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
Endocrinology 1996;137(8):3316-22.
1996: K J Smith; Grant Scotland; J Beattie; I P Trayer; Miles D Houslay
Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs.
The Journal of biological chemistry 1996;271(28):16703-11.
1996: N J Morris; M Bushfield; Miles D Houslay
Streptozotocin-induced diabetes elicits the phosphorylation of hepatocyte Gi2 alpha at the protein kinase C site but not at the protein kinase A-controlled site.
The Biochemical journal 1996;315 ( Pt 2)():417-20.
1996: R A Doris; G E Thompson; E Finley; E Kilgour; Miles D Houslay; Richard G Vernon
Chronic effects of somatotropin treatment on response of subcutaneous adipose tissue lipolysis to acutely acting factors in vivo and in vitro.
Journal of animal science 1996;74(3):562-8.
1996: A M Michie; M Lobban; T Müller; Margaret M Harnett; Miles D Houslay
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
Cellular signalling 1996;8(2):97-110.
1996: G B Bolger; I McPhee; Miles D Houslay
Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.
The Journal of biological chemistry 1996;271(2):1065-71.
1996: Y M Horton; H Lubbert; Miles D Houslay
Localization of the gene for the human serotonin 5-HT(2B) receptor to chromosome 2.
Molecular membrane biology 1996;13(1):29-31.
1995: L Zeng; Miles D Houslay
Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C.
The Biochemical journal 1995;312 ( Pt 3)():769-74.
1995: S Spence; G Rena; G Sweeney; Miles D Houslay
Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms.
The Biochemical journal 1995;310 ( Pt 3)():975-82.
1995: Ian McPhee; L Pooley; M Lobban; Graeme B Bolger; Miles D Houslay
Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family.
The Biochemical journal 1995;310 ( Pt 3)():965-74.
1995: N J Morris; P Young; Miles D Houslay
Insulin inhibits the phosphorylation of alpha-Gi-2 in intact hepatocytes.
The Biochemical journal 1995;308 ( Pt 2)():693-6.
1995: Y M Horton; Michael Sullivan; Miles D Houslay
Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected].
The Biochemical journal 1995;308 ( Pt 2)():683-91.
1995: Grant Scotland; Miles D Houslay
Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase.
The Biochemical journal 1995;308 ( Pt 2)():673-81.
1995: Richard G Vernon; R Doris; E Finley; Miles D Houslay; E Kilgour; S Lindsay-Watt
Effects of lactation on the signal transduction systems regulating lipolysis in sheep subcutaneous and omental adipose tissue.
The Biochemical journal 1995;308 ( Pt 1)():291-6.
1995: Miles D Houslay; Grant Scotland; L Pooley; S Spence; I Wilkinson; F McCallum; P Julien; N G Rena; A M Michie; Suat Erdogan
Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.
Biochemical Society transactions 1995;23(2):393-8.
1995: A Savage; L Zeng; Miles D Houslay
A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes.
The Biochemical journal 1995;307 ( Pt 1)():281-5.
1995: Yasmin Shakur; M Wilson; L Pooley; M Lobban; S L Griffiths; A M Campbell; J Beattie; C Daly; Miles D Houslay
Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum.
The Biochemical journal 1995;306 ( Pt 3)():801-9.
1995: R Doris; E Kilgour; Miles D Houslay; G E Thompson; Richard G Vernon
Modulation of adenosine signalling in sheep adipose tissue by growth hormone.
Biochemical Society transactions 1995;23(1):16S.
1995: Miles D Houslay
Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP.
Advances in enzyme regulation 1995;35():303-38.
1994: M Lobban; Yasmin Shakur; J Beattie; Miles D Houslay
Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions.
The Biochemical journal 1994;304 ( Pt 2)():399-406.
1994: M Wilson; Michael Sullivan; N Brown; Miles D Houslay
Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast.
The Biochemical journal 1994;304 ( Pt 2)():407-15.
1994: M Sullivan; M Egerton; Yasmin Shakur; A Marquardsen; Miles D Houslay
Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1).
Cellular signalling 1994;6(7):793-812.
1994: N J Morris; M Bushfield; B E Lavan; Miles D Houslay
Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes.
The Biochemical journal 1994;301 ( Pt 3)():693-702.
1994: C Livingstone; C MacDonald; Brian J Willett; Miles D Houslay
Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells).
The Biochemical journal 1994;300 ( Pt 3)():835-42.
1994: M K Saville; Miles D Houslay
Phosphorylation of calmodulin on Tyr99 selectively attenuates the action of calmodulin antagonists on type-I cyclic nucleotide phosphodiesterase activity.
The Biochemical journal 1994;299 ( Pt 3)():863-8.
1994: C Loesberg; S Spence; F P Nijkamp; Miles D Houslay
Dietary linoleic acid-induced changes in respiratory beta-adrenergic receptor function and the form of arrhenius plots of isoprenaline- and prostaglandin E2-stimulated adenylate cyclase activity in a model for atopy.
Cellular signalling 1994;6(2):187-99.
1994: R Doris; Richard G Vernon; Miles D Houslay; E Kilgour
Growth hormone decreases the response to anti-lipolytic agonists and decreases the levels of Gi2 in rat adipocytes.
The Biochemical journal 1994;297 ( Pt 1)():41-5.
1994: Miles D Houslay; N J Morris; A Savage; A Marker; M Bushfield
Regulation of hepatocyte adenylate cyclase by amylin and CGRP: a single receptor displaying apparent negative cooperatively towards CGRP and simple saturation kinetics for amylin, a requirement for phosphodiesterase inhibition to observe elevated hepatocyte cyclic AMP levels and the phosphorylation of Gi-2.
Journal of cellular biochemistry 1994;55 Suppl():66-82.
1993: R Doris; Richard G Vernon; Miles D Houslay; E Kilgour
Growth hormone suppresses the expression of Gi2 in rat adipocytes.
Biochemical Society transactions 1993;21(4):432S.
1993: M K Saville; Miles D Houslay
The role of polybasic compounds in determining the tyrosyl phosphorylation of calmodulin by the human insulin receptor.
Cellular signalling 1993;5(6):709-25.
1993: E Y Tang; P J Parker; J Beattie; Miles D Houslay
Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes.
FEBS letters 1993;326(1-3):117-23.
1993: F Irvine; A V Wallace; S R Sarawak; Miles D Houslay
Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes.
The Biochemical journal 1993;293 ( Pt 1)():249-53.
1993: M Bushfield; A Savage; N J Morris; Miles D Houslay
A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor.
The Biochemical journal 1993;293 ( Pt 1)():229-36.
1993: Yasmin Shakur; J G Pryde; Miles D Houslay
Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram.
The Biochemical journal 1993;292 ( Pt 3)():677-86.
1993: S Spence; Miles D Houslay
The role of Gi and the membrane-fluidizing agent benzyl alcohol in modulating the hysteretic activation of human platelet adenylate cyclase by guanylyl 5'-imidodiphosphate.
The Biochemical journal 1993;291 ( Pt 3)():945-9.
1993: A R McLellan; G Milligan; Miles D Houslay; J M Connell
G-proteins in essential hypertension: a study of human platelet plasma membranes.
Journal of hypertension 1993;11(5):543-9.
1993: A R McLellan; G Milligan; Miles D Houslay; J M Connell
G-proteins in experimental hypertension: a study of spontaneously hypertensive rat myocardial and renal cortical plasma membranes.
Journal of hypertension 1993;11(4):365-72.
1992: Timothy Palmer; P V Taberner; Miles D Houslay
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Cellular signalling 1992;4(4):365-77.
1992: Miles D Houslay
G-protein linked receptors: a family probed by molecular cloning and mutagenesis procedures.
Clinical endocrinology 1992;36(6):525-34.
1992: E K Tang; Miles D Houslay
Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity.
The Biochemical journal 1992;283 ( Pt 2)():341-6.
1992: D Strassheim; Miles D Houslay; Graeme Milligan
Regulation of cardiac adenylate cyclase activity in rodent models of obesity.
The Biochemical journal 1992;283 ( Pt 1)():203-8.
1992: Miles D Houslay; S L Griffiths; Y M Horton; C Livingstone; M Lobban; F Macdonald; N Morris; J Pryde; Grant Scotland; Yasmin Shakur
Regulation of intracellular cyclic AMP concentrations in hepatocytes involves the integrated activation and desensitization of adenylyl cyclase coupled with the action and activation of specific isoforms of cyclic AMP phosphodiesterase.
Biochemical Society transactions 1992;20(1):140-6.
1991: Timothy Palmer; Miles D Houslay
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Biochimica et biophysica acta 1991;1097(3):193-204.
1991: C Newlands; Miles D Houslay
Treatment of intact hepatocytes with synthetic diacyl glycerols mimics the ability of glucagon to cause the desensitization of adenylate cyclase.
FEBS letters 1991;289(2):129-32.
1991: D Strassheim; T Palmer; Graeme Milligan; Miles D Houslay
Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats.
The Biochemical journal 1991;276 ( Pt 1)():197-202.
1991: M Bushfield; B E Lavan; Miles D Houslay
Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2.
The Biochemical journal 1991;274 ( Pt 2)():317-21.
1991: C Livingstone; A R McLellan; M A McGregor; A Wilson; J M Connell; M Small; Graeme Milligan; K R Paterson; Miles D Houslay
Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects.
Biochimica et biophysica acta 1991;1096(2):127-33.
1991: D Strassheim; T Palmer; Miles D Houslay
Genetically acquired diabetes: adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation.
Biochimica et biophysica acta 1991;1096(2):121-6.
1991: M Woods; Miles D Houslay
Desensitization of atriopeptin stimulated accumulation and extrusion of cyclic GMP from a kidney epithelial cell line (MDCK).
Biochemical pharmacology 1991;41(3):385-94.
1991: Miles D Houslay
Gi-2 is at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: the fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic states.
Cellular signalling 1991;3(1):1-9.
1991: Miles D Houslay
'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways.
European journal of biochemistry / FEBS 1991;195(1):9-27.
1990: S L Griffiths; J T Knowler; Miles D Houslay
Diabetes-induced changes in guanine-nucleotide-regulatory-protein mRNA detected using synthetic oligonucleotide probes.
European journal of biochemistry / FEBS 1990;193(2):367-74.
1990: M Bushfield; S L Griffiths; G J Murphy; N J Pyne; J T Knowler; Graeme Milligan; P J Parker; S Mollner; Miles D Houslay
Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes.
The Biochemical journal 1990;271(2):365-72.
1990: M Bushfield; N J Pyne; Miles D Houslay
Changes in the phosphorylation state of the inhibitory guanine-nucleotide-binding protein Gi-2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats.
European journal of biochemistry / FEBS 1990;192(2):537-42.
1990: M Hoey; Miles D Houslay
Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney.
Biochemical pharmacology 1990;40(2):193-202.
1990: A V Wallace; B R Martin; Miles D Houslay
Insulin alters the target size of the peripheral cyclic AMP phosphodiesterase but not the integral cyclic GMP-stimulated cyclic AMP phosphodiesterase in liver plasma membranes.
Biochemical and biophysical research communications 1990;169(2):377-82.
1990: S L Griffiths; Miles D Houslay
G-protein alpha-subunit mRNAs in diabetic rat tissues.
Biochemical Society transactions 1990;18(3):475-6.
1990: M Bushfield; Miles D Houslay
Regulation of the phosphorylation state of Gi2 in intact rat hepatocytes.
Biochemical Society transactions 1990;18(3):456.
1990: M Bushfield; G J Murphy; B E Lavan; P J Parker; V J Hruby; Graeme Milligan; Miles D Houslay
Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.
The Biochemical journal 1990;268(2):449-57.
1990: D Strassheim; Graeme Milligan; Miles D Houslay
Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity.
The Biochemical journal 1990;266(2):521-6.
1990: Miles D Houslay
The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations.
Cellular signalling 1990;2(1):85-98.
1990: M Bushfield; S L Griffiths; D Strassheim; E Tang; Yasmin Shakur; B Lavan; Miles D Houslay
Guanine-nucleotide-binding proteins in diabetes and insulin-resistant states.
Biochemical Society symposium 1990;56():137-54.
1990: Miles D Houslay; M Bushfield; G Milligan
Phosphorylation of Gi in intact cells.
Trends in biochemical sciences 1990;15(1):13.
1989: S Spence; Miles D Houslay
The local anaesthetic benzyl alcohol attenuates the alpha 2-adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin.
The Biochemical journal 1989;264(2):483-8.
1989: N J Pyne; C M Heyworth; N W Balfour; Miles D Houslay
Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes.
Biochemical and biophysical research communications 1989;165(1):251-6.
1989: J J Ohisalo; H L Vikman; Sirpa Ranta; Miles D Houslay; G Milligan
Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients.
The Biochemical journal 1989;264(1):289-92.
1989: B E Lavan; T Lakey; Miles D Houslay
Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form.
Biochemical pharmacology 1989;38(22):4123-36.
1989: Shireen A Davies; Miles D Houslay; Michael J O Wakelam
The effects of p21N-ras expression in NIH-3T3 cells upon cyclic AMP metabolism.
Biochimica et biophysica acta 1989;1013(2):173-9.
1989: NG Anderson; E Kilgour; Miles D Houslay
Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase.
The Biochemical journal 1989;262(3):867-72.
1989: F M Mitchell; S L Griffiths; E D Saggerson; Miles D Houslay; J T Knowler; Graeme Milligan
Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to Gi1, Gi2 and Gi3.
The Biochemical journal 1989;262(2):403-8.
1989: Miles D Houslay
Strategies for identifying functionally active domains upon cell surface receptors.
Current opinion in cell biology 1989;1(4):669-74.
1989: Miles D Houslay; N J Pyne; R M O'Brien; K Siddle; D Strassheim; T Palmer; S Spence; M Woods; A Wilson; B Lavan
Guanine nucleotide regulatory proteins in insulin's action and in diabetes.
Biochemical Society transactions 1989;17(4):627-9.
1989: N J Pyne; William Cushley; Hugh G Nimmo; Miles D Houslay
Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes.
The Biochemical journal 1989;261(3):897-904.
1989: D J Gawler; A Wilson; Miles D Houslay
Metformin treatment of lean and obese Zucker rats modulates the ability of glucagon and insulin to regulate hepatocyte adenylate cyclase activity.
The Journal of endocrinology 1989;122(1):207-12.
1989: A C Lloyd; S A Davies; I Crossley; Michael Whitaker; Miles D Houslay; Alan Hall; C J Marshall; M J Wakelam
Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene.
The Biochemical journal 1989;260(3):813-9.
1989: E Kilgour; NG Anderson; Miles D Houslay
Activation and phosphorylation of the 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase.
The Biochemical journal 1989;260(1):27-36.
1989: Graeme Milligan; Shireen A Davies; Miles D Houslay; Michael J O Wakelam
Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism.
Oncogene 1989;4(5):659-63.
1989: G J Murphy; D J Gawler; Graeme Milligan; Michael J O Wakelam; N J Pyne; Miles D Houslay
Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon.
The Biochemical journal 1989;259(1):191-7.
1989: R O'Brien; Miles D Houslay; N P Brindle; G Milligan; J Whittaker; Kenneth Siddle
Binding to GDP-agarose identifies a novel 60kDa substrate for the insulin receptor tyrosyl kinase in mouse NIH-3T3 cells expressing high concentrations of the human insulin receptor.
Biochemical and biophysical research communications 1989;158(3):743-8.
1989: N J Pyne; G J Murphy; Graeme Milligan; Miles D Houslay
Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi.
FEBS letters 1989;243(1):77-82.
1989: Miles D Houslay; D J Gawler; Graeme Milligan; A Wilson
Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
Cellular signalling 1989;1(1):9-22.
1989: Miles D Houslay; K Siddle
Molecular basis of insulin receptor function.
British medical bulletin 1989;45(1):264-84.
1988: L Needham; Miles D Houslay
Tosyl-lysyl chloromethylketone detects conformational changes in the catalytic unit of adenylate cyclase induced by receptor and G-protein stimulation.
Biochemical and biophysical research communications 1988;156(2):855-9.
1988: N J Pyne; Miles D Houslay
An insulin mediator preparation serves to stimulate the cyclic GMP activated cyclic AMP phosphodiesterase rather than other purified insulin-activated cyclic AMP phosphodiesterases.
Biochemical and biophysical research communications 1988;156(1):290-6.
1988: J F Hancock; C J Marshall; I A McKay; S Gardner; Miles D Houslay; Alan Hall; M J Wakelam
Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.
Oncogene 1988;3(2):187-93.
1988: F J Irvine; Miles D Houslay
Treatment of intact hepatocytes with the calcium ionophore A23187 perturbs both the synthesis and the degradation of the second messenger cyclic AMP. Actions on adenylate cyclase and cyclic AMP phosphodiesterase activities.
Biochemical pharmacology 1988;37(14):2773-9.
1988: F J Irvine; Miles D Houslay
Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes.
The Biochemical journal 1988;251(2):447-52.
1988: D Gawler; Graeme Milligan; Miles D Houslay
Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.
The Biochemical journal 1988;249(2):537-42.
1988: G J Murphy; Miles D Houslay
Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.
The Biochemical journal 1988;249(2):543-7.
1988: Alan Hall; C Calés; J F Hancock; A Lloyd; A Self; S Gardener; Miles D Houslay; M J Wakelam; C J Marshall
Analysis of mammalian ras effector function.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():855-62.
1988: Shireen A Davies; Miles D Houslay; Michael J O Wakelam
Effects of transformation by p21N-ras upon the inositol phospholipid and adenylate cyclase signaling pathways in NIH 3T3 cells.
Annals of the New York Academy of Sciences 1988;551():354-7.
1988: Miles D Houslay; N J Pyne; M E Cooper
Isolation and characterization of insulin-stimulated, high-affinity cAMP phosphodiesterases from rat liver.
Methods in enzymology 1988;159():751-60.
1987: N J Pyne; N Anderson; B E Lavan; Graeme Milligan; Hugh G Nimmo; Miles D Houslay
Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat.
The Biochemical journal 1987;248(3):897-901.
1987: B Price; N J Pyne; Miles D Houslay
Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue.
Biochemical pharmacology 1987;36(23):4047-54.
1987: R M O'Brien; K Siddle; Miles D Houslay; Alan Hall
Interaction of the human insulin receptor with the ras oncogene product p21.
FEBS letters 1987;217(2):253-9.
1987: D Gawler; Miles D Houslay
Insulin stimulates a novel GTPase activity in human platelets.
FEBS letters 1987;216(1):94-8.
1987: D Gawler; G Milligan; Allen Spiegel; C G Unson; Miles D Houslay
Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes.
Nature 1987;327(6119):229-32.
1987: L Needham; N J Dodd; Miles D Houslay
Quinidine and melittin both decrease the fluidity of liver plasma membranes and both inhibit hormone-stimulated adenylate cyclase activity.
Biochimica et biophysica acta 1987;899(1):44-50.
1987: G J Murphy; V J Hruby; D Trivedi; M J Wakelam; Miles D Houslay
The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism.
The Biochemical journal 1987;243(1):39-46.
1987: R M O'Brien; Miles D Houslay; G Milligan; K Siddle
The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go.
FEBS letters 1987;212(2):281-8.
1987: N J Pyne; M E Cooper; Miles D Houslay
The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity.
The Biochemical journal 1987;242(1):33-42.
1987: M J Wakelam; Miles D Houslay; S A Davies; C J Marshall; Alan Hall
The role of N-ras p21 in the coupling of growth factor receptors to inositol phospholipid turnover.
Biochemical Society transactions 1987;15(1):45-7.
1987: Miles D Houslay; Michael J O Wakelam; G J Murphy; D J Gawler; N J Pyne
Glucagon stimulates adenylate cyclase through GR2 glucagon receptors: a process which can be attenuated by glucagon stimulating inositol phospholipid metabolism through GR1 glucagon receptors.
Biochemical Society transactions 1987;15(1):21-4.
1986: F Irvine; N J Pyne; Miles D Houslay
The phorbol ester TPA inhibits cyclic AMP phosphodiesterase activity in intact hepatocytes.
FEBS letters 1986;208(2):455-9.
1986: M J Wakelam; S A Davies; Miles D Houslay; I McKay; C J Marshall; Alan Hall
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production.
Nature 1986;323(6084):173-6.
1986: M J Wakelam; G J Murphy; V J Hruby; Miles D Houslay
Activation of two signal-transduction systems in hepatocytes by glucagon.
Nature 1986;323(6083):68-71.
1986: Miles D Houslay; D Bojanic; D Gawler; S O'Hagan; A Wilson
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
The Biochemical journal 1986;238(1):109-13.
1986: Cecilia J Hillard; Alan Bloom; Miles D Houslay
Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes.
Biochemical pharmacology 1986;35(16):2797-803.
1986: Miles D Houslay; L Needham; N J Dodd; A M Grey
Acidic phospholipid species inhibit adenylate cyclase activity in rat liver plasma membranes.
The Biochemical journal 1986;235(1):237-43.
1986: C M Heyworth; A M Grey; S R Wilson; E Hanski; Miles D Houslay
The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
The Biochemical journal 1986;235(1):145-9.
1986: Miles D Houslay
Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver. Twenty-second Colworth medal lecture.
Biochemical Society transactions 1986;14(2):183-93.
1986: Miles D Houslay; D Bojanic; A Wilson
Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.
The Biochemical journal 1986;234(3):737-40.
1986: N J Pyne; M E Cooper; Miles D Houslay
Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver.
The Biochemical journal 1986;234(2):325-34.
1985: C M Heyworth; S P Wilson; D J Gawler; Miles D Houslay
The phorbol ester TPA prevents the expression of both glucagon desensitisation and the glucagon-mediated block of insulin stimulation of the peripheral plasma membrane cyclic AMP phosphodiesterase in rat hepatocytes.
FEBS letters 1985;187(2):196-200.
1985: Miles D Houslay
Regulation of adenylate cyclase (EC 4.6.I.I) activity by its lipid environment.
The Proceedings of the Nutrition Society 1985;44(2):157-65.
1985: C M Heyworth; A D Whetton; S Wong; B R Martin; Miles D Houslay
Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes.
The Biochemical journal 1985;228(3):593-603.
1985: L Needham; I Finnegan; Miles D Houslay
Adenylate cyclase and a fatty acid spin probe detect changes in plasma membrane lipid phase separations induced by dietary manipulation of the cholesterol:phospholipid ratio.
FEBS letters 1985;183(1):81-6.
1984: Miles D Houslay; A V Wallace; M E Cooper; N J Payne; S R Wilson; C M Heyworth
Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein?
Biochemical Society transactions 1984;12(5):766-8.
1984: C M Heyworth; E Hanski; Miles D Houslay
Islet-activating protein blocks glucagon desensitization in intact hepatocytes.
The Biochemical journal 1984;222(1):189-94.
1984: C M Heyworth; A V Wallace; S R Wilson; Miles D Houslay
An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations.
The Biochemical journal 1984;222(1):183-7.
1984: A V Wallace; C M Heyworth; Miles D Houslay
N6-(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes.
The Biochemical journal 1984;222(1):177-82.
1984: O Phillips; Timothy J Mantle; A R Tuffery; C M Heyworth; S R Wilson; Miles D Houslay
On the possible role of biliverdin stimulation of cyclic AMP levels as a trigger for liver regeneration in the rat.
Biochemical pharmacology 1984;33(12):1963-7.
1984: A D Whetton; L Needham; G P Margison; N J Dodd; Miles D Houslay
Dimethylnitrosamine inhibits the glucagon-stimulated adenylate cyclase activity of rat liver plasma membranes and decreases plasma membrane fluidity.
Biochimica et biophysica acta 1984;773(1):106-12.
1984: C M Heyworth; A D Whetton; A R Kinsella; Miles D Houslay
The phorbol ester, TPA inhibits glucagon-stimulated adenylate cyclase activity.
FEBS letters 1984;170(1):38-42.
1984: A R Kinsella; A D Whetton; Erika A de Wynter; G W Bazill; C M Heyworth; Miles D Houslay
Membrane-mediated responses to 12-O-tetradecanoylphorbol-13-acetate in human skin fibroblasts.
IARC scientific publications 1984;(56):177-88.
1984: Dolores J Takemoto; J Hansen; Larry Takemoto; Miles D Houslay; R J Marchmont
Peptide mapping of cyclic nucleotide phosphodiesterases.
Advances in cyclic nucleotide and protein phosphorylation research 1984;16():55-64.
1984: Miles D Houslay; A V Wallace; R J Marchmont; B R Martin; C M Heyworth
Insulin controls intracellular cyclic AMP concentrations in hepatocytes by activating specific cyclic AMP phosphodiesterases: phosphorylation of the peripheral plasma membrane enzyme.
Advances in cyclic nucleotide and protein phosphorylation research 1984;16():159-76.
1983: S R Wilson; A V Wallace; Miles D Houslay
Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes.
The Biochemical journal 1983;216(1):245-8.
1983: C M Heyworth; Miles D Houslay
Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase.
The Biochemical journal 1983;214(2):547-52.
1983: C M Heyworth; Miles D Houslay
Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes.
The Biochemical journal 1983;214(1):93-8.
1983: C M Heyworth; A V Wallace; Miles D Houslay
Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes.
The Biochemical journal 1983;214(1):99-110.
1983: S R Wilson; Miles D Houslay
Proteolytic activation and solubilization of endoplasmic-reticulum cyclic AMP phosphodiesterase activity.
The Biochemical journal 1983;213(1):99-105.
1983: B Cercek; S R Wilson; Miles D Houslay
Heterogeneity of cyclic nucleotide phosphodiesterases in liver endoplasmic reticulum.
The Biochemical journal 1983;213(1):89-97.
1983: A D Whetton; Miles D Houslay
5'-Nucleotidase is activated upon cholesterol-depletion of liver plasma membranes.
FEBS letters 1983;157(1):70-4.
1983: A D Whetton; Larry M Gordon; Miles D Houslay
Adenylate cyclase is inhibited upon depletion of plasma-membrane cholesterol.
The Biochemical journal 1983;212(2):331-8.
1983: A D Whetton; L Needham; N J Dodd; C M Heyworth; Miles D Houslay
Forskolin and ethanol both perturb the structure of liver plasma membranes and activate adenylate cyclase activity.
Biochemical pharmacology 1983;32(10):1601-8.
1983: Miles D Houslay
Dual control of adenylate cyclase.
Nature 1983;303(5913):133.
1983: Miles D Houslay; C M Heyworth; A D Whetton
Mechanism of glucagon activation of adenylate cyclase in the presence of Mn2+.
FEBS letters 1983;155(2):311-6.
1983: C M Heyworth; S Rawal; Miles D Houslay
Guanine nucleotides can activate the insulin-stimulated phosphodiesterase in liver plasma membranes.
FEBS letters 1983;154(1):87-91.
1983: Larry M Gordon; A D Whetton; S Rawal; J A Esgate; Miles D Houslay
Perturbations of liver plasma membranes induced by Ca2+ are detected using a fatty acid spin label and adenylate cyclase as membrane probes.
Biochimica et biophysica acta 1983;729(1):104-14.
1983: A D Whetton; Larry M Gordon; Miles D Houslay
Elevated membrane cholesterol concentrations inhibit glucagon-stimulated adenylate cyclase.
The Biochemical journal 1983;210(2):437-49.
1983: Larry M Gordon; Patrick W Mobley; J A Esgate; G Hofmann; A D Whetton; Miles D Houslay
Thermotropic lipid phase separations in human platelet and rat liver plasma membranes.
The Journal of membrane biology 1983;76(2):139-49.
1982: Dolores J Takemoto; J Hansen; Larry Takemoto; Miles D Houslay
Peptide mapping of multiple forms of cyclic nucleotide phosphodiesterase.
The Journal of biological chemistry 1982;257(24):14597-9.
1982: B Cercek; Miles D Houslay
Submitochondrial localization and asymmetric disposition of two peripheral cyclic nucleotide phosphodiesterases.
The Biochemical journal 1982;207(1):123-32.
1982: L Needham; Miles D Houslay
The activity of dopamine-stimulated adenylate cyclase from rat brain stratum is modulated by temperature and the bilayer-fluidizing agent, benzyl alcohol.
The Biochemical journal 1982;206(1):89-95.
1982: A D Whetton; A Johannsson; S R Wilson; A V Wallace; Miles D Houslay
The thermodependence of the activity of integral enzymes in liver plasma membranes: evidence consistent with a functionally asymmetric lipid bilayer.
FEBS letters 1982;143(1):147-52.
1982: L Needham; A D Whetton; Miles D Houslay
The local anaesthetic and bilayer fluidising agent, benzyl alcohol decreases the thermostability of the integral membrane protein adenylate cyclase.
FEBS letters 1982;140(1):85-8.
1982: I Dipple; Miles D Houslay
Developmental changes in the form of the Arrhenius plots of rat liver plasma membrane adenylate cyclase and 5'-nucleotidase activities.
Biochemical and biophysical research communications 1982;105(1):259-63.
1982: I Dipple; Larry M Gordon; Miles D Houslay
The activity of 5'-nucleotidase in liver plasma membranes is affected by the increase in bilayer fluidity achieved by anionic drugs but not by cationic drugs.
The Journal of biological chemistry 1982;257(4):1811-5.
1981: Miles D Houslay; R J Marchmont
The insulin-stimulated cyclic AMP phosphodiesterase binds to a single class of protein sites on the liver plasma membrane.
The Biochemical journal 1981;198(3):703-6.
1981: Miles D Houslay; I Dipple; Larry M Gordon
Phenobarbital selectively modulates the glucagon-stimulated activity of adenylate cyclase by depressing the lipid phase separation occurring in the outer half of the bilayer of liver plasma membranes.
The Biochemical journal 1981;197(3):675-81.
1981: Miles D Houslay; K R Elliott
Is the receptor-mediated endocytosis of cholera toxin A pre-requisite for its activation of adenylate cyclase in intact rat hepatocytes?
FEBS letters 1981;128(2):289-92.
1981: R J Marchmont; Miles D Houslay
Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes.
The Biochemical journal 1981;195(3):653-60.
1981: R J Marchmont; S R Ayad; Miles D Houslay
Purification and properties of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes.
The Biochemical journal 1981;195(3):645-52.
1981: Miles D Houslay
Membrane phosphorylation: a crucial role in the action of insulin, EGF, and pp60src?
Bioscience reports 1981;1(1):19-34.
1981: Miles D Houslay
Mobile receptor and collision coupling mechanisms for the activation of adenylate cyclase by glucagon.
Advances in cyclic nucleotide research 1981;14():111-9.
1980: Miles D Houslay
Lipid substitution of mitochondrial monoamine oxidase can lead to the abolition of clorgyline selective inhibition without alteration in the A/B ratio assessed by substrate utilisation.
Biochemical pharmacology 1980;29(23):3211-3.
1980: R J Marchmont; Miles D Houslay
Insulin activates a rat liver peripheral plasma-membrane cyclic AMP phosphodiesterase by a phosphorylation mechanism.
Biochemical Society transactions 1980;8(5):537-8.
1980: R J Marchmont; Miles D Houslay
Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase.
Nature 1980;286(5776):904-6.
1980: R J Marchmont; Miles D Houslay
Insulin controls the cyclic AMP-dependent phosphorylation of integral and peripheral proteins associated with the rat liver plasma membrane.
FEBS letters 1980;118(1):18-24.
1980: Miles D Houslay; I Dipple; S Rawal; R D Sauerheber; J A Esgate; Larry M Gordon
Glucagon-stimulated adenylate cyclase detects a selective perturbation of the inner half of the liver plasma-membrane bilayer achieved by the local anaesthetic prilocaine.
The Biochemical journal 1980;190(1):131-7.
1980: Larry M Gordon; R D Sauerheber; J A Esgate; I Dipple; R J Marchmont; Miles D Houslay
The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes.
The Journal of biological chemistry 1980;255(10):4519-27.
1980: R J Marchmont; Miles D Houslay
A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes.
The Biochemical journal 1980;187(2):381-92.
1980: Miles D Houslay; I Dipple; K R Elliott
Guanosine 5'-triphosphate and guanosine 5'-[beta gamma-imido]triphosphate effect a collision coupling mechanism between the glucagon receptor and catalytic unit of adenylate cyclase.
The Biochemical journal 1980;186(3):649-58.
1980: A D Whetton; Miles D Houslay
The effect of vinblastine on the glucagon, basal and GTP-stimulated states of the adenylate cyclase from rat liver plasma membranes.
FEBS letters 1980;111(2):290-4.
1980: Larry M Gordon; I Dipple; R D Sauerheber; J A Esgate; Miles D Houslay
The selective effects of charged local anaesthetics on the glucagon- and fluoride-stimulated adenylate cyclase activity of rat-liver plasma membranes.
Journal of supramolecular structure 1980;14(1):21-32.
1980: Miles D Houslay; R J Marchmont
Exposure of mitochondrial outer membranes to neuraminidase selectively destroys monoamine oxidase A activity.
The Journal of pharmacy and pharmacology 1980;32(1):65-6.
1979: I Dipple; Miles D Houslay
Amphoptericin B has very different effects on the glucagon and fluoride-stimulated adenylate cyclase activities of rat liver plasma membranes.
FEBS letters 1979;106(1):21-4.
1979: Miles D Houslay
Coupling of the glucagon receptor to adenylate cyclase.
Biochemical Society transactions 1979;7(5):843-6.
1979: I Dipple; Miles D Houslay
The temperature dependence of adenylate cyclase activity solubilised using various Lubrol detergents.
Biochemical and biophysical research communications 1979;90(2):663-6.
1979: Miles D Houslay; K R Elliott
Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes.
FEBS letters 1979;104(2):359-63.
1979: Miles D Houslay; R W Palmer
Lysophosphatidylcholines can modulate the activity of the glucagon-stimulated adenylate cyclase from rat liver plasma membranes.
The Biochemical journal 1979;178(1):217-21.
1978: J P Bennett; G A Smith; Miles D Houslay; T R Hesketh; J C Metcalfe; G B Warren
The phospholipid headgroup specificity of an ATP-dependent calcium pump.
Biochimica et biophysica acta 1978;513(3):310-20.
1978: Miles D Houslay; R W Palmer; R J Duncan
The action of the local anaesthetic, benzyl alcohol and the monoamine oxidase inhibitor, clorgyline on the beta-hydroxybutyrate dehydrogenase activity of adult and weanling rat brain mitochondria.
The Journal of pharmacy and pharmacology 1978;30(11):711-4.
1978: Miles D Houslay; R W Palmer
Changes in the form of Arrhenius plots of the activity of glucagon-stimulated adenylate cyclase and other hamster liver plasma-membrane enzymes occurring on hibernation.
The Biochemical journal 1978;174(3):909-19.
1978: I Dipple; Miles D Houslay
The activity of glucagon-stimulated adenylate cyclase from rat liver plasma membranes is modulated by the fluidity of its lipid environment.
The Biochemical journal 1978;174(1):179-90.
1978: I Dipple; K R Elliott; Miles D Houslay
Detergents modify the form of Arrhenius plots of 5'-nucleotidase activity.
FEBS letters 1978;89(1):153-6.
1978: Miles D Houslay
Lysolecithin is a selective reversible inhibitor of mitochondrial monoamine oxidase.
Biochemical pharmacology 1978;27(8):1287-8.
1977: Miles D Houslay
A model for the selective mode of action of the irreversible monoamine oxidase inhibitors clorgyline and deprenyl, based on studies of their ability to activate a Ca2+--Mg2+ ATPase in defined lipid environments.
The Journal of pharmacy and pharmacology 1977;29(11):664-9.
1977: K F Tipton; T J Mantle; Miles D Houslay
A kinetic method for the detection of inhibitory contaminants in radioactive substrates.
Biochemical pharmacology 1977;26(16):1525-7.
1977: C J Fowler; B A Callingham; Miles D Houslay
The effect of tris buffers on rat liver mitochondrial monoamine oxidase.
The Journal of pharmacy and pharmacology 1977;29(7):411-5.
1977: T R Hesketh; G A Smith; Miles D Houslay; G B Warren; J C Metcalfe
Is an early calcium flux necessary to stimulate lymphocytes?
Nature 1977;267(5611):490-4.
1977: Miles D Houslay; J C Ellory; G A Smith; T R Hesketh; J M Stein; G B Warren; J C Metcalfe
Exchange of partners in glucagon receptor-adenylate cyclase complexes. Physical evidence for the independent, mobile receptor model.
Biochimica et biophysica acta 1977;467(2):208-19.
1977: B R Martin; Miles D Houslay; E L Kennedy
Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes.
The Biochemical journal 1977;161(3):639-42.
1977: K F Tipton; T J Mantle; Miles D Houslay
Some problems concerning the apparent multiplicity of monoamine oxidase [proceedings].
Psychopharmacology bulletin 1977;13(1):46-7.
1977: K F Tipton; Miles D Houslay; A J Turner
Metabolism of aldehydes in brain.
Essays in neurochemistry and neuropharmacology 1977;1():103-38.
1976: T R Hesketh; G A Smith; Miles D Houslay; K A McGill; N J Birdsall; J C Metcalfe; G B Warren
Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin.
Biochemistry 1976;15(19):4145-51.
1976: T J Mantle; Miles D Houslay; N J Garrett; K F Tipton
5-Hydroxytryptamine is a substrate for both species of monoamine oxidase in beef heart mitochondria.
The Journal of pharmacy and pharmacology 1976;28(9):667-71.
1976: Miles D Houslay; K F Tipton
Multiple forms of monoamine oxidase: fact and artefact.
Life sciences 1976;19(4):467-77.
1976: Miles D Houslay; T R Hesketh; G A Smith; G B Warren; J C Metcalfe
The lipid environment of the glucagon receptor regulates adenylate cyclase activity.
Biochimica et biophysica acta 1976;436(2):495-504.
1976: Miles D Houslay; J C Metcalfe; G B Warren; T R Hesketh; G A Smith
The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it.
Biochimica et biophysica acta 1976;436(2):489-94.
1975: G B Warren; Miles D Houslay; J C Metcalfe; N J Birdsall
Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein.
Nature 1975;255(5511):684-7.
1975: Miles D Houslay; G B Warren; N J Birdsall; J C Metcalfe
Lipid phase transitions control beta-hydroxybutyrate dehydrogenase activity in defined-lipid protein complexes.
FEBS letters 1975;51(1):146-51.
1975: Miles D Houslay; K F Tipton
Amine competition for oxidation by rat liver mitochondrial monoamine oxidase.
Biochemical pharmacology 1975;24(5):627-31.
1975: Miles D Houslay; K F Tipton
Rat liver mitochondrial monoamine oxidase. A change in the reaction mechanism on solubilization.
The Biochemical journal 1975;145(2):311-21.
1975: Miles D Houslay; K F Tipton
Inhibition of beef plasma amine oxidase by clorgyline.
Biochemical pharmacology 1975;24(3):429-31.
1974: Miles D Houslay; N J Garrett; K F Tipton
Mixed substrate experiments with human brain monoamine oxidase.
Biochemical pharmacology 1974;23(14):1937-44.
1974: Miles D Houslay; K F Tipton
A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes.
The Biochemical journal 1974;139(3):645-52.
1973: K F Tipton; Miles D Houslay; N J Garrett
Allotopic properties of human brain monoamine oxidase.
Nature: New biology 1973;246(155):213-4.
1973: Miles D Houslay; K F Tipton
The reaction pathway of membrane-bound rat liver mitochondrial monoamine oxidase.
The Biochemical journal 1973;135(4):735-50.
1973: Miles D Houslay; K F Tipton
The nature of the electrophoretically separable multiple forms of rat liver monoamine oxidase.
The Biochemical journal 1973;135(1):173-86.