FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Michael McMahon

Research Profile

Chemicals & Drugs

Co-author Network

Publications

TOP 3
John D Hayes; Michael McMahon; Sudhir Chowdhry; Albena T Dinkova-Kostova
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
Michael McMahon; Douglas J Lamont; Kenneth A Beattie; John D Hayes
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
Michael O Kelleher; Michael McMahon; Ian M Eggleston; Mark J Dixon; Keiko Taguchi; Masayuki Yamamoto; John D Hayes
1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Michael McMahon (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2010: John D Hayes; Michael McMahon; Sudhir Chowdhry; Albena T Dinkova-Kostova
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
Antioxidants & redox signaling 2010;13(11):1713-48.
2010: Michael McMahon; Douglas J Lamont; Kenneth A Beattie; John D Hayes
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18838-43.
2009: Michael O Kelleher; Michael McMahon; Ian M Eggleston; Mark J Dixon; Keiko Taguchi; Masayuki Yamamoto; John D Hayes
1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.
Carcinogenesis 2009;30(10):1754-62.
2009: John D Hayes; Albena T Dinkova-Kostova; Michael McMahon
Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):199-201.
2009: A Kenneth MacLeod; Michael McMahon; Simon M Plummer; Larry G Higgins; Trevor M Penning; Kazuhiko Igarashi; John D Hayes
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
Carcinogenesis 2009;30(9):1571-80.
2009: John D Hayes; Michael McMahon
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
Trends in biochemical sciences 2009;34(4):176-88.
2006: Michael McMahon; Nerys Thomas; Ken Itoh; Masayuki Yamamoto; John D Hayes
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
The Journal of biological chemistry 2006;281(34):24756-68.
2006: John D Hayes; Michael McMahon
The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.
Molecular cell 2006;21(6):732-4.
2005: Tim W P Devling; Christopher D Lindsay; Lesley I McLellan; Michael McMahon; John D Hayes
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(20):7280-7285A.
2004: Michael McMahon; Nerys Thomas; Ken Itoh; Masayuki Yamamoto; John D Hayes
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.
The Journal of biological chemistry 2004;279(30):31556-67.
2004: Joanne Mathers; Jennifer A Fraser; Michael McMahon; Robert D C Saunders; John D Hayes; Lesley I McLellan
Antioxidant and cytoprotective responses to redox stress.
Biochemical Society symposium 2004;(71):157-76.
2003: Paul Nioi; Michael McMahon; Ken Itoh; Masayuki Yamamoto; John D Hayes
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.
The Biochemical journal 2003;374(Pt 2):337-48.
2003: Michael McMahon; Ken Itoh; Masayuki Yamamoto; John D Hayes
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
The Journal of biological chemistry 2003;278(24):21592-600.
2002: Simon A Chanas; Qing Jiang; Michael McMahon; Gail K McWalter; Lesley I McLellan; Clifford R Elcombe; Colin Henderson; C Roland Wolf; Graeme J Moffat; Ken Itoh; Masayuki Yamamoto; John D Hayes
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
The Biochemical journal 2002;365(Pt 2):405-16.
2001: John D Hayes; Michael McMahon
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention.
Cancer letters 2001;174(2):103-13.
2001: Michael McMahon; Ken Itoh; Masayuki Yamamoto; Simon A Chanas; Colin Henderson; Lesley I McLellan; C Roland Wolf; Christophe Cavin; John D Hayes
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
Cancer research 2001;61(8):3299-307.
2000: John D Hayes; Simon A Chanas; Colin Henderson; Michael McMahon; C Sun; Graeme J Moffat; C Roland Wolf; Masayuki Yamamoto
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
Biochemical Society transactions 2000;28(2):33-41.