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Lawrence Kirschner

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Lawrence S Kirschner
The next generation of therapies for adrenocortical cancers.
Daphne R Pringle; Zhirong Yin; Lianbo Yu; David Jarjoura; Krista M D La Perle; Audrey A Lee; Parmeet K Manchanda; Alfred F Parlow; Lawrence S Kirschner
Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.
Zhirong Yin; Daphne R Pringle; Georgette N Jones; Kimberly Kelly; Lawrence S Kirschner
Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.

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All Publications

2012: Lawrence S Kirschner
The next generation of therapies for adrenocortical cancers.
Trends in endocrinology and metabolism: TEM 2012;23(7):343-50.
2012: Daphne R Pringle; Zhirong Yin; Lianbo Yu; David Jarjoura; Krista M D La Perle; Audrey A Lee; Parmeet K Manchanda; Alfred F Parlow; Lawrence S Kirschner
Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.
Endocrine-related cancer 2012;19(3):435-46.
2011: Zhirong Yin; Daphne R Pringle; Georgette N Jones; Kimberly Kelly; Lawrence S Kirschner
Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a.
Molecular endocrinology (Baltimore, Md.) 2011;25(10):1786-93.
2010: Lawrence S Kirschner
PRKAR1A and the evolution of pituitary tumors.
Molecular and cellular endocrinology 2010;326(1-2):3-7.
2010: Georgette N Jones; Parmeet K Manchanda; Daphne R Pringle; Mei Zhang; Lawrence S Kirschner
Mouse models of endocrine tumours.
Best practice & research. Clinical endocrinology & metabolism 2010;24(3):451-60.
2010: Kit Man Tsang; Matthew F Starost; Maria Nesterova; Sosipatros A Boikos; Tonya Watkins; Madson Q Almeida; Michelle Harran; Andrew Li; Michael T Collins; Chris Cheadle; Edward L Mertz; Sergey Leikin; Lawrence S Kirschner; Pamela Robey; Constantine A Stratakis
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(19):8683-8.
2009: Lawrence S Kirschner; Zhirong Yin; Georgette N Jones; Emilia Mahoney
Mouse models of altered protein kinase A signaling.
Endocrine-related cancer 2009;16(3):773-93.
2009: Hui-Pin Hsiao; Lawrence S Kirschner; Isabelle Bourdeau; Margaret F Keil; Sosipatros Boikos; Somya Verma; Audrey Robinson-White; Maria Nesterova; André Lacroix; Constantine Straturis
Clinical and genetic heterogeneity, overlap with other tumor syndromes, and atypical glucocorticoid hormone secretion in adrenocorticotropin-independent macronodular adrenal hyperplasia compared with other adrenocortical tumors.
The Journal of clinical endocrinology and metabolism 2009;94(8):2930-7.
2009: Lawrence S Kirschner
Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex.
Journal of internal medicine 2009;266(1):60-8.
2009: Kiran S Nadella; Motoyasu Saji; Naduparambil K Jacob; Emilia Pavel; Matthew D Ringel; Lawrence S Kirschner
Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.
EMBO reports 2009;10(6):599-605.
2009: Zhirong Yin; Lawrence S Kirschner
The Carney complex gene PRKAR1A plays an essential role in cardiac development and myxomagenesis.
Trends in cardiovascular medicine 2009;19(2):44-9.
2008: Georgette N Jones; Chhavy Tep; William H Towns; Georgeta Mihai; Ian D Tonks; Graham F Kay; Petra M Schmalbrock; Anat O Stemmer-Rachamimov; Sung Ok Yoon; Lawrence S Kirschner
Tissue-specific ablation of Prkar1a causes schwannomas by suppressing neurofibromatosis protein production.
Neoplasia (New York, N.Y.) 2008;10(11):1213-21.
2008: Kiran S Nadella; Georgette N Jones; Anthony Trimboli; Constantine Straturis; Gustavo Leone; Lawrence S Kirschner
Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition.
Cancer research 2008;68(8):2671-7.
2008: Zhirong Yin; Georgette N Jones; William H Towns; Xiaoli Zhang; E Dale Abel; philip binkley; David Jarjoura; Lawrence S Kirschner
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Circulation 2008;117(11):1414-22.
2008: Zhirong Yin; Lisa Williams-Simons; A F Parlow; Sylvia Asa; Lawrence S Kirschner
Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):380-7.
2008: Emilia Pavel; Kiran S Nadella; William H Towns; Lawrence S Kirschner
Mutation of Prkar1a causes osteoblast neoplasia driven by dysregulation of protein kinase A.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):430-40.
2008: Zhirong Yin; Lisa Williams-Simons; Lisa Rawahneh; Sylvia Asa; Lawrence S Kirschner
Development of a pituitary-specific cre line targeted to the Pit-1 lineage.
Genesis (New York, N.Y. : 2000) 2008;46(1):37-42.
2007: Leonardo M Porchia; Marcy Guerra; Yu-Chieh Wang; Yunlong Zhang; Allan V Espinosa; Motoo Shinohara; Samuel K Kulp; Lawrence S Kirschner; Motoyasu Saji; Ching-Shih Chen; Matthew D Ringel
2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase.
Molecular pharmacology 2007;72(5):1124-31.
2007: Emilia Pavel; Wenning Zhao; Kimberly A. Powell; Michael Weinstein; Lawrence S Kirschner
Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.
The International journal of developmental biology 2007;51(4):273-81.
2006: Anelia Horvath; Sosipatros Boikos; Christoforos Giatzakis; Audrey Robinson-White; Lionel Groussin; Kurt J Griffin; Erica Stein; Elizabeth Levine; Georgia Delimpasi; Hui Pin Hsiao; Margaret F Keil; Sarah Heyerdahl; Ludmila Matyakhina; Rossella Libè; Amato Fratticci; Lawrence S Kirschner; Kevin Cramer; Rolf C Gaillard; Xavier Bertagna; J Aidan Carney; Jérôme Bertherat; Ioannis Bossis; Constantine Straturis
A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia.
Nature genetics 2006;38(7):794-800.
2006: Lawrence S Kirschner
Emerging treatment strategies for adrenocortical carcinoma: a new hope.
The Journal of clinical endocrinology and metabolism 2006;91(1):14-21.
2005: Kiran S Nadella; Lawrence S Kirschner
Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
Cancer research 2005;65(22):10307-15.
2005: Lawrence S Kirschner; Donna F Kusewitt; Ludmila Matyakhina; William H Towns; J Aidan Carney; Heiner Westphal; Constantine Straturis
A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.
Cancer research 2005;65(11):4506-14.
2004: Kurt J Griffin; Lawrence S Kirschner; Ludmila Matyakhina; Sotirios Stergiopoulos; Audrey Robinson-White; Sara M Lenherr; Frank D Weinberg; Edward Claflin; Elise Meoli; Yoon S Cho-Chung; Constantine Straturis
Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.
Cancer research 2004;64(24):8811-5.
2004: Kurt J Griffin; Lawrence S Kirschner; Ludmila Matyakhina; Sotirios Stergiopoulos; Audrey Robinson-White; Sara M Lenherr; Frank D Weinberg; E S Claflin; Dalia L Batista; Isabelle Bourdeau; Antonis Voutetakis; Fabiano Sandrini; Elise Meoli; A J Bauer; Yoon S Cho-Chung; Stefan R Bornstein; J Aidan Carney; Constantine Straturis
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Journal of medical genetics 2004;41(12):923-31.
2004: Kurt J Griffin; Lawrence S Kirschner; Ludmila Matyakhina; Sotirios Stergiopoulos; Audrey Robinson-White; Frank D Weinberg; Elise Meoli; Stefan R Bornstein; Constantine Straturis
A mouse model for Carney complex.
Endocrine research 2004;30(4):903-11.
2004: Isabelle Bourdeau; Sonir R Antonini; André Lacroix; Lawrence S Kirschner; Ludmila Matyakhina; Dominique Lorang; Steven Libutti; Constantine Straturis
Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators.
Oncogene 2004;23(8):1575-85.
2003: Jérôme Bertherat; Lionel Groussin; Fabiano Sandrini; Ludmila Matyakhina; Thalia Bei; Sotirios Stergiopoulos; Theocharis Papageorgiou; Isabelle Bourdeau; Lawrence S Kirschner; Caroline Vincent-Dejean; Karine Perlemoine; Christine Gicquel; Xavier Bertagna; Constantine Straturis
Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity.
Cancer research 2003;63(17):5308-19.
2003: Ludmila Matyakhina; Svetlana Pack; Lawrence S Kirschner; Evgenia Pak; Poonam Mannan; J Jaikumar; SE Taymans; Fabiano Sandrini; J Aidan Carney; Constantine Straturis
Chromosome 2 (2p16) abnormalities in Carney complex tumours.
Journal of medical genetics 2003;40(4):268-77.
2002: Fabiano Sandrini; Lawrence S Kirschner; Thalia Bei; Constantine Farmakidis; J Yasufuku-Takano; K Takano; T R Prezant; S J Marx; W E Farrell; R N Clayton; Lionel Groussin; Jérôme Bertherat; Constantine Straturis
PRKAR1A, one of the Carney complex genes, and its locus (17q22-24) are rarely altered in pituitary tumours outside the Carney complex.
Journal of medical genetics 2002;39(12):e78.
2002: Lionel Groussin; Lawrence S Kirschner; Caroline Vincent-Dejean; Karine Perlemoine; Eric Jullian; Brigitte Delemer; Sabina Zacharieva; Duarte Pignatelli; J Aidan Carney; Jean Pierre Luton; Xavier Bertagna; Constantine Straturis; Jérôme Bertherat
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
American journal of human genetics 2002;71(6):1433-42.
2002: Lawrence S Kirschner; Constantine Straturis
Protein kinase A and tumorigenicity: the example of micronodular adrenocortical hyperplasia and Carney complex.
Endocrine research 2002;28(4):749-50.
2002: Fabiano Sandrini; Ludmila Matyakhina; Nicholas Sarlis; Lawrence S Kirschner; Constantine Farmakidis; Oliver Gimm; Constantine Straturis
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
Genes, chromosomes & cancer 2002;35(2):182-92.
2002: Lawrence S Kirschner
Signaling pathways in adrenocortical cancer.
Annals of the New York Academy of Sciences 2002;968():222-39.
2001: Fabiano Sandrini; Constantine Farmakidis; Lawrence S Kirschner; S M Wu; A Tullio-Pelet; Stanislas LYONNET; D L Metzger; C J Bourdony; D Tiosano; Wai-Yee Chan; Constantine Straturis
Spectrum of mutations of the AAAS gene in Allgrove syndrome: lack of mutations in six kindreds with isolated resistance to corticotropin.
The Journal of clinical endocrinology and metabolism 2001;86(11):5433-7.
2001: Constantine Straturis; Lawrence S Kirschner; J Aidan Carney
Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation.
The Journal of clinical endocrinology and metabolism 2001;86(9):4041-6.
2000: Lawrence S Kirschner; Fabiano Sandrini; J Monbo; J P Lin; J Aidan Carney; Constantine Straturis
Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex.
Human molecular genetics 2000;9(20):3037-46.
2000: Constantine Straturis; Theocharis Papageorgiou; Ahalya Premkumar; Svetlana Pack; Lawrence S Kirschner; SE Taymans; Zhengping Zhuang; W H Oelkers; J Aidan Carney
Ovarian lesions in Carney complex: clinical genetics and possible predisposition to malignancy.
The Journal of clinical endocrinology and metabolism 2000;85(11):4359-66.
2000: Svetlana D Pack; Lawrence S Kirschner; Evgenia Pak; Zhengping Zhuang; J Aidan Carney; Constantine Straturis
Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas" (Carney complex).
The Journal of clinical endocrinology and metabolism 2000;85(10):3860-5.
2000: Lawrence S Kirschner; J Aidan Carney; Svetlana D Pack; SE Taymans; Christoforos Giatzakis; Y S Cho; Yoon S Cho-Chung; Constantine Straturis
Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex.
Nature genetics 2000;26(1):89-92.
2000: Lawrence S Kirschner; Constantine Straturis
Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes.
Biochemical and biophysical research communications 2000;270(3):1106-10.
2000: Joseph C Watson; Constantine Straturis; P K Bryant-Greenwood; Christian A Koch; Lawrence S Kirschner; T Nguyen; J Aidan Carney; Edward H Oldfield
Neurosurgical implications of Carney complex.
Journal of neurosurgery 2000;92(3):413-8.
1999: Lawrence S Kirschner; SE Taymans; Svetlana Pack; Evgenia Pak; B L Pike; Settara C Chandrasekharappa; Zhengping Zhuang; Constantine Straturis
Genomic mapping of chromosomal region 2p15-p21 (D2S378-D2S391): integration of Genemap'98 within a framework of yeast and bacterial artificial chromosomes.
Genomics 1999;62(1):21-33.
1999: Constantine Straturis; Nicholas Sarlis; Lawrence S Kirschner; J Aidan Carney; John L Doppman; Lynnette K Nieman; George Chrousos; Dimitris A Papanicolaou
Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease.
Annals of internal medicine 1999;131(8):585-91.
1999: Lawrence S Kirschner; Constantine Straturis
Large-scale preparation of sequence-ready bacterial artificial chromosome DNA using QIAGEN columns.
BioTechniques 1999;27(1):72-4.
1999: Emma E Tarttelin; Lawrence S Kirschner; James Bellingham; Judit Baffi; SE Taymans; Kevin Gregory-Evans; Karl G Csaky; Constantine Straturis; Cheryl Y Gregory-Evans
Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16.
Biochemical and biophysical research communications 1999;260(1):174-80.
1999: SE Taymans; Lawrence S Kirschner; Christoforos Giatzakis; Constantine Straturis
Radiation hybrid mapping of chromosomal region 2p15-p16: integration of expressed and polymorphic sequences maps at the Carney complex (CNC) and Doyne honeycomb retinal dystrophy (DHRD) loci.
Genomics 1999;56(3):344-9.
1999: Constantine Straturis; J Aidan Carney; Lawrence S Kirschner; Holger S Willenberg; S Brauer; Monika Ehrhart-Bornstein; Stefan R Bornstein
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex.
The Journal of clinical endocrinology and metabolism 1999;84(3):1122-8.
1999: Lawrence S Kirschner; C N Mariash
Adipose S14 mRNA is abnormally regulated in obese subjects.
Thyroid : official journal of the American Thyroid Association 1999;9(2):143-8.
1998: M Casey; CS Mah; A D Merliss; Lawrence S Kirschner; SE Taymans; A E Denio; B Korf; A D Irvine; A Hughes; J Aidan Carney; Constantine Straturis; Craig T Basson
Identification of a novel genetic locus for familial cardiac myxomas and Carney complex.
Circulation 1998;98(23):2560-6.
1998: Constantine Straturis; Lawrence S Kirschner; J Aidan Carney
Carney complex: diagnosis and management of the complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas.
American journal of medical genetics 1998;80(2):183-5.
1998: Lawrence S Kirschner; SE Taymans; Constantine Straturis
Characterization of the adrenal gland pathology of Carney complex, and molecular genetics of the disease.
Endocrine research 1998;24(3-4):863-4.
1998: Constantine Straturis; Lawrence S Kirschner; SE Taymans; I P Tomlinson; D J Marsh; David Torpy; Christoforos Giatzakis; D M Eccles; J Theaker; R S Houlston; J L Blouin; Stylianos Antonarakis; Craig T Basson; Charis Eng; J Aidan Carney
Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci.
The Journal of clinical endocrinology and metabolism 1998;83(8):2972-6.
1998: Constantine Straturis; Lawrence S Kirschner
Clinical and genetic analysis of primary bilateral adrenal diseases (micro- and macronodular disease) leading to Cushing syndrome.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(6-7):456-63.
1998: Constantine Straturis; Alessandra Vottero; Angela Brodie; Lawrence S Kirschner; D DeAtkine; Qing Lu; W Yue; C S Mitsiades; A W Flor; George Chrousos
The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription.
The Journal of clinical endocrinology and metabolism 1998;83(4):1348-57.
1998: Alessandra Vottero; Lawrence S Kirschner; W Yue; Angela Brodie; Constantine Straturis
P450arom gene expression in peripheral blood lymphocytes: identification of a cryptic splice site for exon-1 after Epstein-Barr virus transformation.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):245-50.