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Jacques Barhanin

Research Profile

Chemicals & Drugs

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Anatomy

Genes & Molecular Sequences

Amino Acid Sequences

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Long QT Syndrome

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Abeer El Wakil; Nicolas Guy; Sascha Bandulik; Jacques Barhanin; Saïd Bendahhou; Bernard Mari; Christof Niehrs; Richard Warth; Maria-Christina Zennaro; Enzo Lalli
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.
David Penton; Markus Reichold; Frank Schweda; Philipp Tauber; Richard Warth; Maria-Christina Zennaro; Thomas Budde; Lu Dang Cong; Abeer El Wakil; Sophia Haubs; Enzo Lalli; Florian Lesage; Sascha Bandulik; Jacques Barhanin
Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.
Franck CHATELAIN; Dominique Douguet; Sylvain Feliciangeli; Jacques Barhanin; Saïd Bendahhou; Delphine Bichet; Markus Reichold; Richard Warth; Florian Lesage
TWIK1, a unique background channel with variable ion selectivity.

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All Publications

2012: Abeer El Wakil; Nicolas Guy; Sascha Bandulik; Jacques Barhanin; Saïd Bendahhou; Bernard Mari; Christof Niehrs; Richard Warth; Maria-Christina Zennaro; Enzo Lalli
Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.
Human molecular genetics 2012;21(22):4922-9.
2012: David Penton; Markus Reichold; Frank Schweda; Philipp Tauber; Richard Warth; Maria-Christina Zennaro; Thomas Budde; Lu Dang Cong; Abeer El Wakil; Sophia Haubs; Enzo Lalli; Florian Lesage; Sascha Bandulik; Jacques Barhanin
Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.
Endocrinology 2012;153(10):4740-8.
2012: Franck CHATELAIN; Dominique Douguet; Sylvain Feliciangeli; Jacques Barhanin; Saïd Bendahhou; Delphine Bichet; Markus Reichold; Richard Warth; Florian Lesage
TWIK1, a unique background channel with variable ion selectivity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5499-504.
2011: Sylvain Bartolami; Mélanie Cavalier; Sophie Gaboyard-Niay; Julie Quentin; Cécile Travo; Jacques Barhanin; Christian Chabbert
Critical roles of transitional cells and Na/K-ATPase in the formation of vestibular endolymph.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(46):16541-9.
2010: S Bandulik; D Penton; Jacques Barhanin; Richard Warth
TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2010;42(6):450-7.
2010: Patricia Preston; Lena Wartosch; Dorothee Günzel; Michael Fromm; Patthara Kongsuphol; Jiraporn Ousingsawat; Karl Kunzelmann; Jacques Barhanin; Richard Warth; Thomas J Jentsch
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
The Journal of biological chemistry 2010;285(10):7165-75.
2010: Sylvain Feliciangeli; Magalie P Tardy; guillaume sandoz; Franck CHATELAIN; Richard Warth; Jacques Barhanin; Saïd Bendahhou; Florian Lesage
Potassium channel silencing by constitutive endocytosis and intracellular sequestration.
The Journal of biological chemistry 2010;285(7):4798-805.
2010: Christian Gestreau; Dirk Heitzmann; Joerg Thomas; Véronique Dubreuil; Sascha Bandulik; Markus Reichold; Saïd Bendahhou; Patricia Pierson; Christina Sterner; Julie Peyronnet-Roux; Chérif Benfriha; Ines Tegtmeier; Hannah Ehnes; Michael Georgieff; Florian Lesage; Jean-Francois Brunet; Christo Goridis; Richard Warth; Jacques Barhanin
Task2 potassium channels set central respiratory CO2 and O2 sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2325-30.
2010: Christophe Duranton; Isabelle Rubera; Sebastien L'hoste; Marc Cougnon; Philippe Poujeol; Jacques Barhanin; Michel Tauc
KCNQ1 K+ channels are involved in lipopolysaccharide-induced apoptosis of distal kidney cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(4-5):367-78.
2009: Véronique Dubreuil; Jacques Barhanin; Christo Goridis; Jean-François Brunet
Breathing with phox2b.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1529):2477-83.
2009: Guy Salama; Linda Baker; Robert Wolk; Jacques Barhanin; Barry London
Arrhythmia phenotype in mouse models of human long QT.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 2009;24(2):77-87.
2009: Alice Guyon; Magalie P Tardy; C Rovère; Jean-Louis Nahon; Jacques Barhanin; Florian Lesage
Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(8):2528-33.
2008: Dirk Heitzmann; Renaud Derand; Stefan Jungbauer; Sascha Bandulik; Christina Sterner; Frank Schweda; Abeer El Wakil; Enzo Lalli; Nicolas Guy; Raymond Mengual; Markus Reichold; Ines Tegtmeier; Saïd Bendahhou; Celso E Gomez-Sanchez; M Isabel Aller; william wisden; Achim Weber; Florian Lesage; Richard Warth; Jacques Barhanin
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.
The EMBO journal 2008;27(1):179-87.
2007: Sébastien L'Hoste; Mallorie Poet; Christophe Duranton; Radia Belfodil; Herv é Barriere; Isabelle Rubera; Michel Tauc; Chantal Poujeol; Jacques Barhanin; Philippe Poujeol
Role of TASK2 in the control of apoptotic volume decrease in proximal kidney cells.
The Journal of biological chemistry 2007;282(50):36692-703.
2007: Sylvain Feliciangeli; Saïd Bendahhou; guillaume sandoz; Pierre GOUNON; Markus Reichold; Richard Warth; Michel Lazdunski; Jacques Barhanin; Florian Lesage
Does sumoylation control K2P1/TWIK1 background K+ channels?
Cell 2007;130(3):563-9.
2007: Paulo S Pinheiro; David Perrais; Françoise Coussen; Jacques Barhanin; Bernhard Bettler; Jeffrey R Mann; João O Malva; Stephen F Heinemann; Christophe Mulle
GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12181-6.
2007: Saïd Bendahhou; Emmanuel Fournier; Serge Gallet; Dominique Ménard; Marie-Madeleine Larroque; Jacques Barhanin
Corticosteroid-exacerbated symptoms in an Andersen's syndrome kindred.
Human molecular genetics 2007;16(8):900-6.
2007: Philippe Chevalier; Chloé Bellocq; Gilles Millat; Eric Piqueras; Franck Potet; Jean-Jacques Schott; Isabelle Baro; Herve LeMarec; Jacques Barhanin; Robert Rousson; Claire Rodriguez-Lafrasse
Torsades de pointes complicating atrioventricular block: evidence for a genetic predisposition.
Heart rhythm : the official journal of the Heart Rhythm Society 2007;4(2):170-4.
2007: Sébastien L'Hoste; Herve Barriere; Radia Belfodil; Isabelle Rubera; Christophe Duranton; Michel Tauc; Chantal Poujeol; Jacques Barhanin; Philippe Poujeol
Extracellular pH alkalinization by Cl-/HCO3- exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.
American journal of physiology. Renal physiology 2007;292(2):F628-38.
2006: ID Millar; H C Taylor; GJ Cooper; Jonathan D Kibble; Jacques Barhanin; L Robson
Adaptive downregulation of a quinidine-sensitive cation conductance in renal principal cells of TWIK-1 knockout mice.
Pflügers Archiv : European journal of physiology 2006;453(1):107-16.
2006: Heidi Fodstad; Saïd Bendahhou; Jean-Sébastien Rougier; Päivi J Laitinen-Forsblom; Jacques Barhanin; Hugues Abriel; Laurent Schild; Kimmo Kontula; Heikki Swan
Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients.
Annals of medicine 2006;38(4):294-304.
2005: Xin Nie; Isabelle Arrighi; Brigitte Kaissling; Imke L Pfaff; Jeffrey Mann; Jacques Barhanin; Volker Vallon
Expression and insights on function of potassium channel TWIK-1 in mouse kidney.
Pflügers Archiv : European journal of physiology 2005;451(3):479-88.
2005: Saïd Bendahhou; Céline Marionneau; Karinne Haurogne; Marie-Madeleine Larroque; Renaud Derand; Viktoria Szuts; Denis Escande; Sophie Demolombe; Jacques Barhanin
In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart.
Cardiovascular research 2005;67(3):529-38.
2005: Min Xia; Qingfeng Jin; Saïd Bendahhou; Yusong He; Marie-Madeleine Larroque; Yiping Chen; Qinshu Zhou; Yiqing Yang; Yi Liu; Ban Liu; Qian Zhu; Yanting Zhou; Jie Lin; Bo Liang; Li Li; Xiongjian Dong; Zhiwen Pan; Rongrong Wang; Haiying Wan; Weiqin Qiu; Wenyuan Xu; Petra Eurlings; Jacques Barhanin; Yihan Chen
A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation.
Biochemical and biophysical research communications 2005;332(4):1012-9.
2005: Saïd Bendahhou; Emmanuel Fournier; Damien Sternberg; guillaume bassez; Alain Furby; Carole Sereni; Matthew R Donaldson; Marie-Madeleine Larroque; Bertrand Fontaine; Jacques Barhanin
In vivo and in vitro functional characterization of Andersen's syndrome mutations.
The Journal of physiology 2005;565(Pt 3):731-41.
2004: Dirk Heitzmann; Florian Grahammer; Thomas von Hahn; Annette Schmitt-Gräff; Elisa Romeo; Roland Nitschke; Uwe Gerlach; Hans-Jochen Lang; François Verrey; Jacques Barhanin; Richard Warth
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
The Journal of physiology 2004;561(Pt 2):547-57.
2004: Sonia Decressac; Michel Franco; Saïd Bendahhou; Richard Warth; Sebastian Knauer; Jacques Barhanin; Michel Lazdunski; Florian Lesage
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6.
EMBO reports 2004;5(12):1171-5.
2004: Yiqing Yang; Min Xia; Qingfeng Jin; Saïd Bendahhou; Jingyi Shi; Yiping Chen; Bo Liang; Jie Lin; Yi Liu; Ban Liu; Qinshu Zhou; Dongwei Zhang; Rong Wang; Ning Ma; Xiaoyan Su; Kaiya Niu; Yan Pei; Wenyuan Xu; Zhaopeng Chen; Haiying Wan; Jianmin Cui; Jacques Barhanin; Yihan Chen
Identification of a KCNE2 gain-of-function mutation in patients with familial atrial fibrillation.
American journal of human genetics 2004;75(5):899-905.
2004: Marie-Thérèse Nicolas; Florian Lesage; Roberto Reyes; Jacques Barhanin; Danielle Demêmes
Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat.
Brain research 2004;1017(1-2):46-52.
2004: Richard Warth; Hervé Barrière; Pierre Meneton; May Bloch; Jörg Thomas; Michel Tauc; Dirk Heitzmann; Elisa Romeo; François Verrey; Raymond Mengual; Nicolas Guy; Saïd Bendahhou; Florian Lesage; Philippe Poujeol; Jacques Barhanin
Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8215-20.
2003: Herve Barriere; Radia Belfodil; Isabelle Rubera; Michel Tauc; Florian Lesage; Chantal Poujeol; Nicolas Guy; Jacques Barhanin; Philippe Poujeol
Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules.
The Journal of general physiology 2003;122(2):177-90.
2003: Marie-Thérèse Nicolas; Jacques Barhanin; R Reyes; Danielle Demêmes
Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear.
Hearing research 2003;181(1-2):20-6.
2003: Hervé Barrière; Isabelle Rubera; Radia Belfodil; Michel Tauc; N Tonnerieux; Chantal Poujeol; Jacques Barhanin; Philippe Poujeol
Swelling-activated chloride and potassium conductance in primary cultures of mouse proximal tubules. Implication of KCNE1 protein.
The Journal of membrane biology 2003;193(3):153-70.
2003: Richard Warth; Jacques Barhanin
Function of K+ channels in the intestinal epithelium.
The Journal of membrane biology 2003;193(2):67-78.
2003: Yi-Han Chen; Shi-Jie Xu; Saïd Bendahhou; Xiao-Liang Wang; Ying Wang; Wen-Ying Xu; Hong-Wei Jin; Hao Sun; Xiao-Yan Su; Qi-Nan Zhuang; Yi-Qing Yang; Yue-Bin Li; Yi Liu; Hong-Ju Xu; Xiao-Fei Li; Ning Ma; Chun-Ping Mou; Zhu Chen; Jacques Barhanin; Wei Huang
KCNQ1 gain-of-function mutation in familial atrial fibrillation.
Science (New York, N.Y.) 2003;299(5604):251-4.
2002: Milou-Daniel Drici; Linda Baker; Patricia Plan; Jacques Barhanin; Georges Romey; Guy Salama
Mice display sex differences in halothane-induced polymorphic ventricular tachycardia.
Circulation 2002;106(4):497-503.
2002: Richard Warth; Meritxell Garcia Alzamora; J K Kim; A Zdebik; Roland Nitschke; Markus Bleich; Uwe Gerlach; Jacques Barhanin; S J Kim
The role of KCNQ1/KCNE1 K(+) channels in intestine and pancreas: lessons from the KCNE1 knockout mouse.
Pflügers Archiv : European journal of physiology 2002;443(5-6):822-8.
2002: Richard Warth; Jacques Barhanin
The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(3):R639-48.
2001: Florian Grahammer; Richard Warth; Jacques Barhanin; Markus Bleich; MJ Hug
The small conductance K+ channel, KCNQ1: expression, function, and subunit composition in murine trachea.
The Journal of biological chemistry 2001;276(45):42268-75.
2001: RB Puchalski; E Kelly; Alexander A Bachmanov; S P Brazier; J Kuang; Isabelle Arrighi; Jacques Barhanin; Michael G Tordoff
NaCl consumption is attenuated in female KCNE1 null mutant mice.
Physiology & behavior 2001;74(3):267-76.
2001: Volker Vallon; Florian Grahammer; Kerstin Richter; Markus Bleich; Florian Lang; Jacques Barhanin; Harald Völkl; Richard Warth
Role of KCNE1-dependent K+ fluxes in mouse proximal tubule.
Journal of the American Society of Nephrology : JASN 2001;12(10):2003-11.
2001: Isabelle Arrighi; May Bloch-Faure; Florian Grahammer; Markus Bleich; Richard Warth; R Mengual; Milou-Daniel Drici; Jacques Barhanin; Pierre Meneton
Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8792-7.
2001: Florian Grahammer; A W Herling; Hans-Jochen Lang; Annette Schmitt-Gräff; Oliver H Wittekindt; Roland Nitschke; Markus Bleich; Jacques Barhanin; Richard Warth
The cardiac K+ channel KCNQ1 is essential for gastric acid secretion.
Gastroenterology 2001;120(6):1363-71.
2001: D Chabannes; Jacques Barhanin; Denis Escande
Mice disrupted for the KvLQT1 potassium channel regulator IsK gene accumulate mature T cells.
Cellular immunology 2001;209(1):1-9.
2001: Marie-Thérèse Nicolas; Danielle Demêmes; A Martin; S Kupershmidt; Jacques Barhanin
KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells.
Hearing research 2001;153(1-2):132-45.
2000: Norbert Tinel; Sylvie Diochot; Marc Borsotto; Michel Lazdunski; Jacques Barhanin
KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel.
The EMBO journal 2000;19(23):6326-30.
2000: Norbert Tinel; Sylvie Diochot; Inger Lauritzen; Jacques Barhanin; Michel Lazdunski; Marc Borsotto
M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.
FEBS letters 2000;480(2-3):137-41.
2000: C Chouabe; Nathalie Neyroud; Pascale Richard; Isabelle Denjoy; Bernard Hainque; Georges Romey; Milou-Daniel Drici; Pascale Guicheney; Jacques Barhanin
Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk.
Cardiovascular research 2000;45(4):971-80.
2000: C Chouabe; Milou-Daniel Drici; Georges Romey; Jacques Barhanin
Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs.
Thérapie 2000;55(1):195-202.
2000: Milou-Daniel Drici; Jacques Barhanin
Cardiac K+ channels and drug-acquired long QT syndrome.
Thérapie 2000;55(1):185-93.
1999: Pierre Meneton; Florian Lesage; Jacques Barhanin
Potassium ATPases, channels, and transporters: an overview.
Seminars in nephrology 1999;19(5):438-57.
1999: Douglas Vetter; M Charles Liberman; J Mann; Jacques Barhanin; Jim Boulter; M C Brown; J Saffiote-Kolman; Stephen F Heinemann; Ana Belen Elgoyhen
Role of alpha9 nicotinic ACh receptor subunits in the development and function of cochlear efferent innervation.
Neuron 1999;23(1):93-103.
1999: silvia priori; Jacques Barhanin; Richard N W Hauer; W Haverkamp; HJ Jongsma; AG Kleber; WJ McKenna; Dan Mark Roden; Y Rudy; K Schwartz; PJ Schwartz; JA Towbin; A M Wilde
Genetic and molecular basis of cardiac arrhythmias: impact on clinical management part III.
Circulation 1999;99(5):674-81.
1999: silvia priori; Jacques Barhanin; Richard N W Hauer; W Haverkamp; HJ Jongsma; AG Kleber; WJ McKenna; Dan Mark Roden; Y Rudy; K Schwartz; PJ Schwartz; JA Towbin; A M Wilde
Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II.
Circulation 1999;99(4):518-28.
1999: silvia priori; Jacques Barhanin; Richard N W Hauer; W Haverkamp; HJ Jongsma; AG Kleber; WJ McKenna; Dan Mark Roden; Y Rudy; K Schwartz; PJ Schwartz; JA Towbin; Arthur Wilde
Genetic and molecular basis of cardiac arrhythmias; impact on clinical management. Study group on molecular basis of arrhythmias of the working group on arrhythmias of the european society of cardiology.
European heart journal 1999;20(3):174-95.
1998: C Chouabe; Milou-Daniel Drici; Georges Romey; Jacques Barhanin; Michel Lazdunski
HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers.
Molecular pharmacology 1998;54(4):695-703.
1998: Milou-Daniel Drici; Isabelle Arrighi; C Chouabe; J R Mann; Michel Lazdunski; Georges Romey; Jacques Barhanin
Involvement of IsK-associated K+ channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome.
Circulation research 1998;83(1):95-102.
1998: Jacques Barhanin; Bernard Attali; M Lazdunski
IKs, a slow and intriguing cardiac K+ channel and its associated long QT diseases.
Trends in cardiovascular medicine 1998;8(5):207-14.
1998: Isabelle Arrighi; Florian Lesage; Jean-Claude Scimeca; Georges F Carle; Jacques Barhanin
Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene.
FEBS letters 1998;425(2):310-6.
1998: Sophie Demolombe; Isabelle Baro; Yann Péréon; Jet Bliek; R Mohammad-Panah; H Pollard; S Morid; marcel mannens; Arthur Wilde; Jacques Barhanin; Flavien Charpentier; Denis Escande
A dominant negative isoform of the long QT syndrome 1 gene product.
The Journal of biological chemistry 1998;273(12):6837-43.
1997: C Chouabe; Nathalie Neyroud; Pascale Guicheney; Michel Lazdunski; Georges Romey; Jacques Barhanin
Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.
The EMBO journal 1997;16(17):5472-9.
1997: Georges Romey; Bernard Attali; C Chouabe; I Abitbol; E Guillemare; Jacques Barhanin; Michel Lazdunski
Molecular mechanism and functional significance of the MinK control of the KvLQT1 channel activity.
The Journal of biological chemistry 1997;272(27):16713-6.
1997: Serge Bischoff; Jacques Barhanin; Bernhard Bettler; Christophe Mulle; S Heinemann
Spatial distribution of kainate receptor subunit mRNA in the mouse basal ganglia and ventral mesencephalon.
The Journal of comparative neurology 1997;379(4):541-62.
1997: Nathalie Neyroud; F Tesson; Isabelle Denjoy; M Leibovici; C Donger; Jacques Barhanin; S Fauré; F Gary; Philippe Coumel; C Petit; Ketty Schwartz; Pascale Guicheney
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome.
Nature genetics 1997;15(2):186-9.
1996: Douglas Vetter; J R Mann; Philine Wangemann; J Liu; K J McLaughlin; F Lesage; Daniel C Marcus; M Lazdunski; Stephen F Heinemann; Jacques Barhanin
Inner ear defects induced by null mutation of the isk gene.
Neuron 1996;17(6):1251-64.
1996: Jacques Barhanin; Florian Lesage; E Guillemare; M Fink; Michel Lazdunski; Georges Romey
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.
Nature 1996;384(6604):78-80.
1996: M Fink; Fabrice DUPRAT; Florian Lesage; Catherine Heurteaux; Georges Romey; Jacques Barhanin; Michel Lazdunski
A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression.
The Journal of biological chemistry 1996;271(42):26341-8.
1996: Florian Lesage; M Mattéi; M Fink; Jacques Barhanin; Michel Lazdunski
Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43.
Genomics 1996;34(1):153-5.
1996: Florian Lesage; E Guillemare; M Fink; Fabrice DUPRAT; Michel Lazdunski; Georges Romey; Jacques Barhanin
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
The EMBO journal 1996;15(5):1004-11.
1996: Florian Lesage; E Guillemare; M Fink; Fabrice DUPRAT; Michel Lazdunski; Georges Romey; Jacques Barhanin
A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties.
The Journal of biological chemistry 1996;271(8):4183-7.
1996: M Fink; Fabrice DUPRAT; Catherine Heurteaux; Florian Lesage; Georges Romey; Jacques Barhanin; Michel Lazdunski
Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end.
FEBS letters 1996;378(1):64-8.
1995: Florian Lesage; E Guillemare; M Fink; Fabrice DUPRAT; Catherine Heurteaux; M Fosset; Georges Romey; Jacques Barhanin; Michel Lazdunski
Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.
The Journal of biological chemistry 1995;270(48):28660-7.
1995: Florian Lesage; M Fink; Jacques Barhanin; Michel Lazdunski; M G Mattéi
Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23.
Genomics 1995;29(3):808-9.
1995: Fabrice DUPRAT; Florian Lesage; E Guillemare; M Fink; Jean-Philippe Hugnot; J Bigay; Michel Lazdunski; Georges Romey; Jacques Barhanin
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.
Biochemical and biophysical research communications 1995;212(2):657-63.
1994: Florian Lesage; Jean-Philippe Hugnot; Ez-Zoubir Amri; P Grimaldi; Jacques Barhanin; Michel Lazdunski
Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator.
Nucleic acids research 1994;22(18):3685-8.
1994: Eric Honoré; E Guillemare; Florian Lesage; Jacques Barhanin; Michel Lazdunski
Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos.
FEBS letters 1994;348(3):259-62.
1994: Eric Honoré; Jacques Barhanin; Bernard Attali; Florian Lesage; Michel Lazdunski
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1937-41.
1994: Gérard Lambeau; Philippe Ancian; Jacques Barhanin; Michel Lazdunski
Cloning and expression of a membrane receptor for secretory phospholipases A2.
The Journal of biological chemistry 1994;269(3):1575-8.
1993: Bernard Attali; Florian Lesage; P Ziliani; E Guillemare; Eric Honoré; Rainer Waldmann; Jean-Philippe Hugnot; M G Mattéi; Michel Lazdunski; Jacques Barhanin
Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel.
The Journal of biological chemistry 1993;268(32):24283-9.
1993: Bernard Attali; E Guillemare; Florian Lesage; Eric Honoré; Georges Romey; Michel Lazdunski; Jacques Barhanin
The protein IsK is a dual activator of K+ and Cl- channels.
Nature 1993;365(6449):850-2.
1993: C Chevillard; Bernard Attali; Florian Lesage; M Fontes; Jacques Barhanin; M Lazdunski; M G Mattei
Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization.
Genomics 1993;15(1):243-5.
1993: Florian Lesage; Bernard Attali; J Lakey; Eric Honoré; Georges Romey; E Faurobert; Michel Lazdunski; Jacques Barhanin
Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression?
Receptors & channels 1993;1(2):143-52.
1992: E Guillemare; Eric Honoré; L Pradier; Florian Lesage; H Schweitz; Bernard Attali; Jacques Barhanin; Michel Lazdunski
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2.
Biochemistry 1992;31(49):12463-8.
1992: Florian Lesage; Bernard Attali; Michel Lazdunski; Jacques Barhanin
Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.
FEBS letters 1992;310(2):162-6.
1992: Eric Honoré; Bernard Attali; Georges Romey; Florian Lesage; Jacques Barhanin; Michel Lazdunski
Different types of K+ channel current are generated by different levels of a single mRNA.
The EMBO journal 1992;11(7):2465-71.
1992: Bernard Attali; Eric Honoré; Florian Lesage; Michel Lazdunski; Jacques Barhanin
Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes.
FEBS letters 1992;303(2-3):229-32.
1992: E Honore; Bernard Attali; Florian Lesage; Jacques Barhanin; Michel Lazdunski
Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes.
Biochemical and biophysical research communications 1992;184(3):1135-41.
1992: Bernard Attali; Georges Romey; Eric Honoré; Annie Schmid-Alliana; M G Mattéi; Florian Lesage; P Ricard; Jacques Barhanin; Michel Lazdunski
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
The Journal of biological chemistry 1992;267(12):8650-7.
1992: Florian Lesage; Bernard Attali; Michel Lazdunski; Jacques Barhanin
ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse.
FEBS letters 1992;301(2):168-72.
1991: Gérard Lambeau; Jacques Barhanin; Michel Lazdunski
Identification of different receptor types for toxic phospholipases A2 in rabbit skeletal muscle.
FEBS letters 1991;293(1-2):29-33.
1991: Eric Honoré; Bernard Attali; Georges Romey; Catherine Heurteaux; P Ricard; Florian Lesage; Michel Lazdunski; Jacques Barhanin
Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart.
The EMBO journal 1991;10(10):2805-11.
1991: Gérard Lambeau; M Lazdunski; Jacques Barhanin
Properties of receptors for neurotoxic phospholipases A2 in different tissues.
Neurochemical research 1991;16(6):651-8.
1990: Gérard Lambeau; Annie Schmid-Alliana; Michel Lazdunski; Jacques Barhanin
Identification and purification of a very high affinity binding protein for toxic phospholipases A2 in skeletal muscle.
The Journal of biological chemistry 1990;265(16):9526-32.
1990: M I Senni; Luciana De Angelis; Clara Nervi; armando curci; Jacques Barhanin; Mario Molinaro; Giulio Cossu
Altered protein phosphorylation in murine muscular dystrophy.
Journal of the neurological sciences 1990;96(2-3):303-19.
1990: Sergio Salvatori; Ernesto Damiani; Jacques Barhanin; Sandra Furlan; Giovanni Salviati; Alfredo Margreth
Co-localization of the dihydropyridine receptor and the cyclic AMP-binding subunit of an intrinsic protein kinase to the junctional membrane of the transverse tubules of skeletal muscle.
The Biochemical journal 1990;267(3):679-87.
1990: J M Séquier; J Brennand; Jacques Barhanin; Michel Lazdunski
Regional expression of a MCD-peptide and dendrotoxin I-sensitive voltage-dependent potassium channel in rat brain.
FEBS letters 1990;263(1):163-5.
1990: M Toutant; Jacqueline Gabrion; Sylvie F. Vandaele; S Peraldi-Roux; Jacques Barhanin; J Bockaert; Bruno Rouot
Cellular distribution and biochemical characterization of G proteins in skeletal muscle: comparative location with voltage-dependent calcium channels.
The EMBO journal 1990;9(2):363-9.
1989: S Pelzer; Jacques Barhanin; David Pauron; W Trautwein; Michel Lazdunski; DJ Pelzer
Diversity and novel pharmacological properties of Ca2+ channels in Drosophila brain membranes.
The EMBO journal 1989;8(8):2365-71.
1989: Gérard Lambeau; Jacques Barhanin; H Schweitz; J Qar; Michel Lazdunski
Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom.
The Journal of biological chemistry 1989;264(19):11503-10.
1989: A Schmid; Georges Romey; Jacques Barhanin; Michel Lazdunski
SR33557, an indolizinsulfone blocker of Ca2+ channels: identification of receptor sites and analysis of its mode of action.
Molecular pharmacology 1989;35(6):766-73.
1989: Jacques Barhanin; M Borsotto; T Coppola; M Fosset; M M Hosey; C Mourre; David Pauron; J Qar; Georges Romey; A Schmid
Biochemistry, molecular pharmacology, and functional control of Ca2+ channels.
Annals of the New York Academy of Sciences 1989;560():15-26.
1989: C Van Renterghem; Paul Vigne; Jacques Barhanin; Annie Schmid-Alliana; Christian Frelin; Michel Lazdunski
Molecular mechanism of endothelin-1 action on aortic cells.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S186-7.
1988: C Van Renterghem; Paul Vigne; Jacques Barhanin; Annie Schmid-Alliana; Christian Frelin; Michel Lazdunski
Molecular mechanism of action of the vasoconstrictor peptide endothelin.
Biochemical and biophysical research communications 1988;157(3):977-85.
1988: M Toutant; Jacques Barhanin; J Bockaert; Bruno Rouot
G-proteins in skeletal muscle. Evidence for a 40 kDa pertussis-toxin substrate in purified transverse tubules.
The Biochemical journal 1988;254(2):405-9.
1988: J Qar; Jacques Barhanin; Georges Romey; R Henning; U Lerch; R Oekonomopulos; H Urbach; Michel Lazdunski
A novel high affinity class of Ca2+ channel blockers.
Molecular pharmacology 1988;33(4):363-9.
1988: Jacques Barhanin; A Schmid; Michel Lazdunski
Properties of structure and interaction of the receptor for omega-conotoxin, a polypeptide active on Ca2+ channels.
Biochemical and biophysical research communications 1988;150(3):1051-62.
1988: Michel Lazdunski; Jacques Barhanin; M Borsotto; C Cognard; C Cooper; T Coppola; M Fosset; J P Galizzi; M M Hosey; C Mourre
Molecular properties of structure and regulation of the calcium channel.
Annals of the New York Academy of Sciences 1988;522():134-49.
1987: David Pauron; J Qar; Jacques Barhanin; D Fournier; André Cuany; M Pralavorio; J B Berge; Michel Lazdunski
Identification and affinity labeling of very high affinity binding sites for the phenylalkylamine series of Ca+ channel blockers in the Drosophila nervous system.
Biochemistry 1987;26(20):6311-5.
1987: MM Hosey; Jacques Barhanin; A Schmid; Sylvie F. Vandaele; J Ptasienski; C O'Callahan; C Cooper; Michel Lazdunski
Photoaffinity labelling and phosphorylation of a 165 kilodalton peptide associated with dihydropyridine and phenylalkylamine-sensitive calcium channels.
Biochemical and biophysical research communications 1987;147(3):1137-45.
1987: Jacques Barhanin; T Coppola; A Schmid; M Borsotto; Michel Lazdunski
The calcium channel antagonists receptor from rabbit skeletal muscle. Reconstitution after purification and subunit characterization.
European journal of biochemistry / FEBS 1987;164(3):525-31.
1987: C L Cooper; Sylvie F. Vandaele; Jacques Barhanin; M Fosset; Michel Lazdunski; MM Hosey
Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue.
The Journal of biological chemistry 1987;262(2):509-12.
1986: A Schmid; Jacques Barhanin; C Mourre; T Coppola; M Borsotto; Michel Lazdunski
Antibodies reveal the cytolocalization and subunit structure of the 1,4-dihydropyridine component of the neuronal Ca2+ channel.
Biochemical and biophysical research communications 1986;139(3):996-1002.
1986: P Dreyfus; François Rieger; M Murawsky; L Garcia; A Lombet; M Fosset; David Pauron; Jacques Barhanin; M Lazdunski
The voltage-dependent sodium channel is co-localized with the acetylcholine receptor at the vertebrate neuromuscular junction.
Biochemical and biophysical research communications 1986;139(1):196-201.
1986: A Schmid; Jacques Barhanin; T Coppola; M Borsotto; Michel Lazdunski
Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent Ca2+ channels in skeletal, cardiac, and smooth muscles.
Biochemistry 1986;25(12):3492-5.
1986: J P Galizzi; M Borsotto; Jacques Barhanin; M Fosset; Michel Lazdunski
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
The Journal of biological chemistry 1986;261(3):1393-7.
1986: M Lazdunski; C Frelin; Jacques Barhanin; A Lombet; H Meiri; David Pauron; Georges Romey; A Schmid; H Schweitz; Paul Vigne
Polypeptide toxins as tools to study voltage-sensitive Na+ channels.
Annals of the New York Academy of Sciences 1986;479():204-20.
1986: Michel Lazdunski; Jacques Barhanin; M Borsotto; M Fosset; J P Galizzi; J F Renaud; Georges Romey; A Schmid
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Journal of cardiovascular pharmacology 1986;8 Suppl 8():S13-9.
1985: M Borsotto; Jacques Barhanin; M Fosset; M Lazdunski
The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel. Purification and subunit composition.
The Journal of biological chemistry 1985;260(26):14255-63.
1985: David Pauron; Jacques Barhanin; M Lazdunski
The voltage-dependent Na+ channel of insect nervous system identified by receptor sites for tetrodotoxin, and scorpion and sea anemone toxins.
Biochemical and biophysical research communications 1985;131(3):1226-33.
1985: Jacques Barhanin; H Meiri; Georges Romey; David Pauron; M Lazdunski
A monoclonal immunotoxin acting on the Na+ channel, with properties similar to those of a scorpion toxin.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(6):1842-6.
1984: M Borsotto; Jacques Barhanin; R I Norman; M Lazdunski
Purification of the dihydropyridine receptor of the voltage-dependent Ca2+ channel from skeletal muscle transverse tubules using (+) [3H]PN 200-110.
Biochemical and biophysical research communications 1984;122(3):1357-66.
1984: Jacques Barhanin
[Molecular characterization of the voltage-dependent sodium channel].
Biochimie 1984;66(6):VII-IX.
1984: W Hanke; G Boheim; Jacques Barhanin; David Pauron; M Lazdunski
Reconstitution of highly purified saxitoxin-sensitive Na+-channels into planar lipid bilayers.
The EMBO journal 1984;3(3):509-15.
1984: Jacques Barhanin; M Ildefonse; O Rougier; Suely V Sampaio; José R Giglio; M Lazdunski
Tityus gamma toxin, a high affinity effector of the Na+ channel in muscle, with a selectivity for channels in the surface membrane.
Pflügers Archiv : European journal of physiology 1984;400(1):22-7.
1984: Jacques Barhanin; David Pauron; A Lombet; W Hanke; G Boheim; M Lazdunski
New scorpion toxins with a very high affinity for Na+ channels. Biochemical characterization and use for the purification of Na+ channels.
Journal de physiologie 1984;79(4):304-8.
1983: R I Norman; A Schmid; A Lombet; Jacques Barhanin; M Lazdunski
Purification of binding protein for Tityus gamma toxin identified with the gating component of the voltage-sensitive Na+ channel.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(13):4164-8.
1983: Jacques Barhanin; A Schmid; A Lombet; K P Wheeler; M Lazdunski; J C Ellory
Molecular size of different neurotoxin receptors on the voltage-sensitive Na+ channel.
The Journal of biological chemistry 1983;258(2):700-2.
1983: Jacques Barhanin; David Pauron; A Lombet; R I Norman; H P Vijverberg; J R Giglio; M Lazdunski
Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain.
The EMBO journal 1983;2(6):915-20.
1982: Jacques Barhanin; José R Giglio; P Léopold; A Schmid; Suely V Sampaio; M Lazdunski
Tityus serrulatus venom contains two classes of toxins. Tityus gamma toxin is a new tool with a very high affinity for studying the Na+ channel.
The Journal of biological chemistry 1982;257(21):12553-8.
1982: K P Wheeler; Jacques Barhanin; M Lazdunski
Specific binding of toxin II from Centruroides suffusus suffusus to the sodium channel in electroplaque membranes.
Biochemistry 1982;21(22):5628-34.
1982: E Jaimovich; M Ildefonse; Jacques Barhanin; O Rougier; M Lazdunski
Centruroides toxin, a selective blocker of surface Na+ channels in skeletal muscle: voltage-clamp analysis and biochemical characterization of the receptor.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(12):3896-900.
1981: H Schweitz; J P Vincent; Jacques Barhanin; C Frelin; G Linden; M Hugues; M Lazdunski
Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus, and Actinodendron plumosum.
Biochemistry 1981;20(18):5245-52.
1981: Jacques Barhanin; M Hugues; H Schweitz; J P Vincent; M Lazdunski
Structure-function relationships of sea anemone toxin II from Anemonia sulcata.
The Journal of biological chemistry 1981;256(11):5764-9.
1980: J F Renaud; Jacques Barhanin; D Cavey; M Fosset; M Lazdunski
Comparative properties of the in ovo and in vitro differentiation of the muscarinic cholinergic receptor in embryonic heart cells.
Developmental biology 1980;78(1):184-200.
1980: J P Vincent; M Balerna; Jacques Barhanin; M Fosset; M Lazdunski
Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1646-50.
1980: M Lazdunski; M Balerna; Jacques Barhanin; R Chicheportiche; M Fosset; C Frelin; Y Jacques; A Lombet; J Pouysségur; J F Renaud; Georges Romey; H Schweitz; J P Vincent
Molecular aspects of the structure and mechanism of the voltage-dependent sodium channel.
Annals of the New York Academy of Sciences 1980;358():169-82.