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Frans Leenen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
44
Huang, Bing
19
Ruzicka, Marcel
15
Yuan, B
10
Tsoporis, james/jim
9
Wang, Hao
9
White, Roselyn
8
Tan, Junhui
8
Fourney, Anne
6
Coletta, Elizabeth
5
Davis, Barry
5
Van Huysse, James
5
Veerasingham, Shereeni
5
Budzikowski, Adam
4
Cushman, William
4
Vahid-Ansari, F

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Publications

TOP 3
Fodor J George; Leenen Frans H H; Helis Eftyhia; Turton Penelope
2006 Ontario Survey on the Prevalence and Control of Hypertension (ON-BP): rationale and design of a community-based cross-sectional survey.
Leenen Frans H H; Dumais Jean; McInnis Natalie H; Turton Penelope; Stratychuk Lori; Nemeth Kathleen; Lum-Kwong Margaret Moy; Fodor George
Results of the Ontario survey on the prevalence and control of hypertension.
Liang Binhui; Leenen Frans H H
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.

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All Publications

2008: Fodor J George; Leenen Frans H H; Helis Eftyhia; Turton Penelope
2006 Ontario Survey on the Prevalence and Control of Hypertension (ON-BP): rationale and design of a community-based cross-sectional survey.
The Canadian journal of cardiology 2008;24(6):503-5.
2008: Leenen Frans H H; Dumais Jean; McInnis Natalie H; Turton Penelope; Stratychuk Lori; Nemeth Kathleen; Lum-Kwong Margaret Moy; Fodor George
Results of the Ontario survey on the prevalence and control of hypertension.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2008;178(11):1441-9.
2008: Liang Binhui; Leenen Frans H H
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.
Journal of cardiovascular pharmacology 2008;51(5):457-66.
2008: Myers Martin G; McInnis Natalie H; Fodor George J; Leenen Frans H H
Comparison between an automated and manual sphygmomanometer in a population survey.
American journal of hypertension 2008;21(3):280-3.
2007: Ruzicka Marcel; Coletta Elizabeth; Leenen Frans H H
Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients?
American journal of hypertension 2007;20(11):1202-8.
2007: Liang B; Leenen F H H
Prevention of salt induced hypertension and fibrosis by angiotensin converting enzyme inhibitors in Dahl S rats.
British journal of pharmacology 2007;152(6):903-14.
2007: Huang Bing S; Ahmad Monir; Tan Junhui; Leenen Frans H H
Sympathetic hyperactivity and cardiac dysfunction post-MI: different impact of specific CNS versus general AT1 receptor blockade.
Journal of molecular and cellular cardiology 2007;43(4):479-86.
2007: Tesson Frédérique; Leenen Frans H H
Still building on candidate-gene strategy in hypertension?
Hypertension 2007;50(4):607-8.
2007: Leenen Frans H H
Brain mechanisms contributing to sympathetic hyperactivity and heart failure.
Circulation research 2007;101(3):221-3.
2007: Leenen Frans H H; Coletta Elizabeth; Davies Ross A
Prevention of renal dysfunction and hypertension by amlodipine after heart transplant.
The American journal of cardiology 2007;100(3):531-5.
2007: Huang Bing S; Ahmad Monir; Deng Alan Y; Leenen Frans H H
Neuronal responsiveness to central Na+ in 2 congenic strains of Dahl salt-sensitive rats.
Hypertension 2007;49(6):1315-20.
2007: Leenen Frans H H; Fourney Anne; Coletta Elizabeth; White Roselyn
Effects of hypertension on cardiovascular responses to epinephrine in humans.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H3025-31.
2007: Myers M G; Leenen F H H;
The impact of one or two missed doses on the duration of action of combined perindopril and indapamide.
Journal of human hypertension 2007;21(1):86-93.
2007: Shehata Marlene F; Leenen Frans H H; Tesson Frédérique
Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats.
BMC genetics 2007;8():35.
2006: Leenen Frans H H; Nwachuku Chuke E; Black Henry R; Cushman William C; Davis Barry R; Simpson Lara M; Alderman Michael H; Atlas Steven A; Basile Jan N; Cuyjet Aloysius B; Dart Richard; Felicetta James V; Grimm Richard H; Haywood L Julian; Jafri Syed Z A; Proschan Michael A; Thadani Udho; Whelton Paul K; Wright Jackson T;
Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.
Hypertension 2006;48(3):374-84.
2006: Huang Bing S; Cheung Warren J; Wang Hao; Tan Junhui; White Roselyn A; Leenen Frans H H
Activation of brain renin-angiotensin-aldosterone system by central sodium in Wistar rats.
American journal of physiology. Heart and circulatory physiology 2006;291(3):H1109-17.
2006: Ruzicka Marcel; Leenen Frans H H
Moving beyond guidelines: are report cards the answer to high rates of uncontrolled hypertension?
Current hypertension reports 2006;8(4):324-9.
2006: Cheung Warren J; Kent Mary-Anne H; El-Shahat Esraa; Wang Hongwei; Tan Junhui; White Roselyn; Leenen Frans H H
Central and peripheral renin-angiotensin systems in ouabain-induced hypertension.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H624-30.
2006: Huang Bing S; Amin Md Shahrier; Leenen Frans H H
The central role of the brain in salt-sensitive hypertension.
Current opinion in cardiology 2006;21(4):295-304.
2006: Dean Stephanie A; Tan Junhui; White Roselyn; O'Brien Edward R; Leenen Frans H H
Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(1):R155-62.
2006: Davis Barry R; Piller Linda B; Cutler Jeffrey A; Furberg Curt; Dunn Kay; Franklin Stanley; Goff David; Leenen Frans; Mohiuddin Syed; Papademetriou Vasilios; Proschan Michael; Ellsworth Allan; Golden John; Colon Pedro; Crow Richard;
Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Circulation 2006;113(18):2201-10.
2006: Leenen Frans Hh; Coletta Elizabeth; White Roselyn
Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release.
Journal of hypertension 2006;24(1):177-84.
2006: Myers Martin G; Leenen Frans H H;
Persistence of the antihypertensive effect of low-dose combination therapy in mild hypertension.
Blood pressure 2006;15(6):325-32.
2005: MacKinnon Martin; Leenen Frans H H; Ruzicka Marcel
Does ALLHAT change the management of hypertension in chronic kidney disease?
Current hypertension reports 2005;7(6):474-83.
2005: Amin Md Shahrier; Wang Hong-Wei; Reza Erona; Whitman Stewart C; Tuana Balwant S; Leenen Frans H H
Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(6):R1787-97.
2005: Lal Avtar; Veinot John P; Ganten Detlev; Leenen Frans H H
Prevention of cardiac remodeling after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Journal of molecular and cellular cardiology 2005;39(3):521-9.
2005: Whelton Paul K; Barzilay Joshua; Cushman William C; Davis Barry R; Iiamathi Ekambaram; Kostis John B; Leenen Frans H H; Louis Gail T; Margolis Karen L; Mathis David E; Moloo Jamal; Nwachuku Chuke; Panebianco Deborah; Parish David C; Pressel Sara; Simmons Debra L; Thadani Udho;
Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Archives of internal medicine 2005;165(12):1401-9.
2005: Leenen Frans H H; Coletta Elizabeth; Fourney Anne; White Roselyn
Aging and cardiac responses to epinephrine in humans: role of neuronal uptake.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2498-503.
2005: Huang Bing S; Leenen Frans H H
Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2491-7.
2005: Wright Jackson T; Dunn J Kay; Cutler Jeffrey A; Davis Barry R; Cushman William C; Ford Charles E; Haywood L Julian; Leenen Frans H H; Margolis Karen L; Papademetriou Vasilios; Probstfield Jeffrey L; Whelton Paul K; Habib Gabriel B;
Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril.
JAMA : the journal of the American Medical Association 2005;293(13):1595-608.
2005: Dean Stephanie A; Tan Junhui; O'Brien Edward R; Leenen Frans H H
17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(3):R759-66.
2005: Tan Junhui; Wang Jun Ming; Leenen Frans H H
Inhibition of brain angiotensin-converting enzyme by peripheral administration of trandolapril versus lisinopril in Wistar rats.
American journal of hypertension 2005;18(2 Pt 1):158-64.
2005: Huang Bing S; Wang Hao; Leenen Frans H H
Chronic central infusion of aldosterone leads to sympathetic hyperreactivity and hypertension in Dahl S but not Dahl R rats.
American journal of physiology. Heart and circulatory physiology 2005;288(2):H517-24.
2004: Lal Avtar; Veinot John P; Leenen Frans H H
Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats.
Cardiovascular research 2004;64(3):437-47.
2004: Leenen Frans H H
ALLHAT: what has it taught us so far?
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2004;171(7):719-20.
2004: Huang Bing S; Van Vliet Bruce N; Leenen Frans H H
Increases in CSF [Na+] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet.
American journal of physiology. Heart and circulatory physiology 2004;287(3):H1160-6.
2004: Leenen Frans H H
Blood pressure lowering, not vascular mechanism of action, is the primary determinant of clinical outcome.
The Canadian journal of cardiology 2004;20 Suppl B():77B-82B.
2004: Kent Mary-Anne H; Huang Bing S; Van Huysse James W; Leenen Frans H H
Brain Na+,K+-ATPase isozyme activity and protein expression in ouabain-induced hypertension.
Brain research 2004;1018(2):171-80.
2004: Ruzicka Marcel; Coletta Elizabeth; Floras John; Leenen Frans H H
Effects of low-dose nifedipine GITS on sympathetic activity in young and older patients with hypertension.
Journal of hypertension 2004;22(5):1039-44.
2004: Tan Junhui; Wang Hao; Leenen Frans H H
Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1665-71.
2004: Wang Hao; Huang Bing S; Ganten Detlev; Leenen Frans H H Leenen
Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Circulation research 2004;94(6):843.
2003: Wang Hao; Huang Bing S; Leenen Frans H H
Brain sodium channels and ouabainlike compounds mediate central aldosterone-induced hypertension.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2516-23.
2003: Wang Hao; White Roselyn; Leenen Frans H H
Stimulation of brain Na+ channels by FMRFamide in Dahl SS and SR rats.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2013-8.
2003: Wang Jun Ming; Veerasingham Shereeni J; Tan Junhui; Leenen Frans H H
Effects of high salt intake on brain AT1 receptor densities in Dahl rats.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H1949-55.
2003: Huang Bing S; Leenen Frans H H
Sympathoinhibitory and depressor effects of amlodipine in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2003;42(2):153-60.
2003: Wang Hao; Leenen Frans H H
Brain sodium channels and central sodium-induced increases in brain ouabain-like compound and blood pressure.
Journal of hypertension 2003;21(8):1519-24.
2003: Lal Avtar; Veinot John P; Leenen Frans H H
Prevention of high salt diet-induced cardiac hypertrophy and fibrosis by spironolactone.
American journal of hypertension 2003;16(4):319-23.
2003: Wang Jun Ming; Tan Junhui; Leenen Frans H H
Central nervous system blockade by peripheral administration of AT1 receptor blockers.
Journal of cardiovascular pharmacology 2003;41(4):593-9.
2002: Ruzicka Marcel; Leenen Frans H H
Combination therapy as first-line treatment of arterial hypertension.
The Canadian journal of cardiology 2002;18(12):1317-27.
2002: Leenen Frans H H; Myers Martin G; Joyner Campbell D; Toal Corey B
Differential effects of once-daily antihypertensive drugs on blood pressure, left ventricular mass and sympathetic activity: Nifedipine-GITS versus felodipine-ER versus enalapril.
The Canadian journal of cardiology 2002;18(12):1285-93.
2002: Wang Jun Ming; Slembrouck Dirk; Tan Junhui; Arckens Lut; Leenen Frans H H; Courtoy Pierre J; De Potter Werner P
Presence of cellular renin-angiotensin system in chromaffin cells of bovine adrenal medulla.
American journal of physiology. Heart and circulatory physiology 2002;283(5):H1811-8.
2002: Chow Michael K; Shao Qiming; Ren Bin; Leenen Frans H H; Van Huysse James W
Changes in brain Na, K-ATPase isoform expression and enzymatic activity after aortic constriction.
Brain research 2002;944(1-2):124-34.
2002: Wang Hao; Leenen Frans H H
Brain sodium channels mediate increases in brain "ouabain" and blood pressure in Dahl S rats.
Hypertension 2002;40(1):96-100.
2002: McAlister Finlay A; Zarnke Kelly B; Campbell Norman R C; Feldman Ross D; Levine Mitchell; Mahon Jeff; Grover Steven A; Lewanczuk Richard; Leenen Frans; Tobe Sheldon; Lebel Marcel; Stone James; Schiffrin Ernesto L; Rabkin Simon W; Ogilvie Richard I; Larochelle Pierre; Jones Charlotte; Honos George; Fodor George; Burgess Ellen; Hamet Pavel; Herman Robert; Irvine Jane; Culleton Bruce; Wright James M;
The 2001 Canadian recommendations for the management of hypertension: Part two--Therapy.
The Canadian journal of cardiology 2002;18(6):625-41.
2002: Leenen Frans H H
Conflicts of interest and libel action.
The New England journal of medicine 2002;346(24):1919-20; author reply 1919-20.
2002: Leenen Frans H H; Ruzicka Marcel; Huang Bing S
The brain and salt-sensitive hypertension.
Current hypertension reports 2002;4(2):129-35.
2002: Izzard Ashley S; Heagerty Anthony M; Leenen Frans H H
The amplifier hypothesis: persisting dissent.
Journal of hypertension 2002;20(3):375-7.
2002: Huang Bing S; Leenen Frans H H
Brain amiloride-sensitive Phe-Met-Arg-Phe-NH(2)--gated Na(+) channels and Na(+)-induced sympathoexcitation and hypertension.
Hypertension 2002;39(2 Pt 2):557-61.
2001: Wright J T; Cushman W C; Davis B R; Barzilay J; Colon P; Egan D; Lucente T; Nwachuku C; Pressel S; Leenen F H; Frolkis J; Letterer R; Walsh S; Tobin J N; Deger G E;
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): clinical center recruitment experience.
Controlled clinical trials 2001;22(6):659-73.
2001: Leenen F H; White R; Yuan B
Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2410-6.
2001: Huang B S; Wang H; Leenen F H
Enhanced sympathoexcitatory and pressor responses to central Na+ in Dahl salt-sensitive vs. -resistant rats.
American journal of physiology. Heart and circulatory physiology 2001;281(5):H1881-9.
2001: Zhang J; Leenen F H
Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin II and sodium.
Canadian journal of physiology and pharmacology 2001;79(10):861-7.
2001: Budzikowski A S; Leenen F H
ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1210-6.
2001: Leenen F H; Ruzicka M; Huang B S
Central sympathoinhibitory effects of calcium channel blockers.
Current hypertension reports 2001;3(4):314-21.
2001: McAlister F A; Levine M; Zarnke K B; Campbell N; Lewanczuk R; Leenen F; Rabkin S; Wright J M; Stone J; Feldman R D; Lebel M; Honos G; Fodor G; Burgess E; Tobe S; Hamet P; Herman R; Irvine J; Culleton B; Petrella R; Touyz R;
The 2000 Canadian recommendations for the management of hypertension: Part one--therapy.
The Canadian journal of cardiology 2001;17(5):543-59.
2001: Leenen F H; Yuan B
Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.
Hypertension 2001;37(3):981-4.
2001: Zhang J; Leenen F H
AT(1) receptor blockers prevent sympathetic hyperactivity and hypertension by chronic ouabain and hypertonic saline.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1318-23.
2001: Huang B S; Ganten D; Leenen F H
Responses to central Na(+) and ouabain are attenuated in transgenic rats deficient in brain angiotensinogen.
Hypertension 2001;37(2 Part 2):683-6.
2001: Leenen F H; Yuan B
Mortality after coronary artery occlusion in different models of cardiac hypertrophy in rats.
Hypertension 2001;37(2):209-15.
2001: Zhao X; White R; Huang B S; Van Huysse J; Leenen F H
High salt intake and the brain renin--angiotensin system in Dahl salt-sensitive rats.
Journal of hypertension 2001;19(1):89-98.
2001: Ruzicka M; Leenen F H
Monotherapy versus combination therapy as first line treatment of uncomplicated arterial hypertension.
Drugs 2001;61(7):943-54.
2000: Huang B S; Murzenok P P; Leenen F H
Sympathoinhibitory and depressor responses to long-term infusion of nifedipine in spontaneously hypertensive rats on high-salt diet.
Journal of cardiovascular pharmacology 2000;36(6):704-10.
2000: Kumarathasan R; Leenen F H
Effects of soybean lipoxygenase on Na+/K+-ATPase activity in vitro.
Canadian journal of physiology and pharmacology 2000;78(9):691-5.
2000: Zhao X; White R; Van Huysse J; Leenen F H
Cardiac hypertrophy and cardiac renin-angiotensin system in Dahl rats on high salt intake.
Journal of hypertension 2000;18(9):1319-26.
2000: Veerasingham S J; Vahid-Ansari F; Leenen F H
Neuronal Fos-like immunoreactivity in ouabain-induced hypertension.
Brain research 2000;876(1-2):17-21.
2000: Leenen F H; Tanner J; McNally C F
Antihypertensive efficacy of the ACE-inhibitor perindopril in the elderly.
Journal of human hypertension 2000;14(5):321-5.
2000: Kala G; Kumarathasan R; Peng L; Leenen F H; Hertz L
Stimulation of Na+,K+-ATPase activity, increase in potassium uptake, and enhanced production of ouabain-like compounds in ammonia-treated mouse astrocytes.
Neurochemistry international 2000;36(3):203-11.
2000: Murzenok P P; Huang B S; Leenen F H
Sympathoinhibition by central and peripheral infusion of nifedipine in spontaneously hypertensive rats.
Hypertension 2000;35(2):631-6.
2000: Huang B S; Yuan B; Leenen F H
Chronic blockade of brain "ouabain" prevents sympathetic hyper-reactivity and impairment of acute baroreflex resetting in rats with congestive heart failure.
Canadian journal of physiology and pharmacology 2000;78(1):45-53.
2000: Kumarathasan R; Leenen F H
Is ATP a substrate for 15-lipoxygenase?
Biochemistry and cell biology = Biochimie et biologie cellulaire 2000;78(2):87-91.
1999: Izzard A S; Heagerty A M; Leenen F H
The amplifier hypothesis: permission to dissent?
Journal of hypertension 1999;17(12 Pt 1):1667-9.
1999: Leenen F H; Yuan B; Huang B S
Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction.
The American journal of physiology 1999;277(5 Pt 2):H1786-92.
1999: Tan K W; Leenen F H
Persistence of anti-hypertensive effect after missed dose of perindopril.
British journal of clinical pharmacology 1999;48(4):628-30.
1999: Huang B S; Kudlac M; Kumarathasan R; Leenen F H
Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation.
Hypertension 1999;34(4 Pt 2):733-8.
1999: Ruzicka M; Yuan B; Leenen F H
Blockade of AT(1) receptors and Na(+)/H(+) exchanger and LV dysfunction after myocardial infarction in rats.
The American journal of physiology 1999;277(2 Pt 2):H610-6.
1999: Leenen F H
Calcium antagonists "some agents lower blood pressure and still put the heart at risk"?
Clinical and experimental hypertension (New York, N.Y. : 1993) 1999;21(5-6):823-34.
1999: Huang B S; Leenen F H
Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats.
Hypertension 1999;34(1):107-12.
1999: Leenen F H
Intermittent blood pressure control: potential consequences for outcome.
The Canadian journal of cardiology 1999;15 Suppl C():13C-18C.
1999: Fodor J G; Whitmore B; Leenen F; Larochelle P
Lifestyle modifications to prevent and control hypertension. 5. Recommendations on dietary salt. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;160(9 Suppl):S29-34.
1999: Zhang W; Huang B S; Leenen F H
Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction.
The American journal of physiology 1999;276(5 Pt 2):H1608-15.
1999: Leenen F H
Cardiovascular consequences of sympathetic hyperactivity.
The Canadian journal of cardiology 1999;15 Suppl A():2A-7A.
1999: White M; Fourney A; Mikes E; Leenen F H
Effects of age and hypertension on cardiac responses to the alpha1-agonist phenylephrine in humans.
American journal of hypertension 1999;12(2 Pt 1):151-8.
1999: Huang B S; Leenen F H
Sympathoinhibitory effects of central nifedipine in spontaneously hypertensive rats on high versus regular sodium intake.
Hypertension 1999;33(1):32-5.
1999: Leenen F H; Skarda V; Yuan B; White R
Changes in cardiac ANG II postmyocardial infarction in rats: effects of nephrectomy and ACE inhibitors.
The American journal of physiology 1999;276(1 Pt 2):H317-25.
1999: Veerasingham S J; Leenen F H
Ouabain- and central sodium-induced hypertension depend on the ventral anteroventral third ventricle region.
The American journal of physiology 1999;276(1 Pt 2):H63-70.
1999: Feldman R D; Campbell N; Larochelle P; Bolli P; Burgess E D; Carruthers S G; Floras J S; Haynes R B; Honos G; Leenen F H; Leiter L A; Logan A G; Myers M G; Spence J D; Zarnke K B
1999 Canadian recommendations for the management of hypertension. Task Force for the Development of the 1999 Canadian Recommendations for the Management of Hypertension.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;161 Suppl 12():S1-17.
1998: Huang B S; Leenen F H
Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake.
Hypertension 1998;32(6):1028-33.
1998: Vahid-Ansari F; Leenen F H
Pattern of neuronal activation in rats with CHF after myocardial infarction.
The American journal of physiology 1998;275(6 Pt 2):H2140-6.
1998: Leenen F H; Davies R A; Fourney A
Catecholamines and heart function in heart transplant patients: effects of beta1- versus nonselective beta-blockade.
Clinical pharmacology and therapeutics 1998;64(5):522-35.
1998: Leenen F H
Regression of cardiac hypertrophy by 1,4 dihydropyridines in hypertensive patients.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1998;16(5):S9-15.
1998: Van Huysse J W; Leenen F H
Role of endogenous brain "ouabain" in the sympathoexcitatory and pressor effects of sodium.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(5-6):657-67.
1998: Budzikowski A S; Vahid-Ansari F; Leenen F H
Chronic activation of brain areas by high-sodium diet in Dahl salt-sensitive rats.
The American journal of physiology 1998;274(6 Pt 2):H2046-52.
1998: Leenen F H; Yuan B
Dietary-sodium-induced cardiac remodeling in spontaneously hypertensive rat versus Wistar-Kyoto rat.
Journal of hypertension 1998;16(6):885-92.
1998: White M; Fourney A; Leenen F H
Age, hypertension, and cardiac responses to beta-agonist in humans.
Clinical pharmacology and therapeutics 1998;63(6):663-71.
1998: Tsoporis J; Keeley F W; Lee R M; Leenen F H
Arterial vasodilation and vascular connective tissue changes in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1998;31(6):960-2.
1998: Huang B S; Veerasingham S J; Leenen F H
Brain "ouabain," ANG II, and sympathoexcitation by chronic central sodium loading in rats.
The American journal of physiology 1998;274(4 Pt 2):H1269-76.
1998: Budzikowski A S; Huang B S; Leenen F H
Brain "ouabain", a neurosteroid, mediates sympathetic hyperactivity in salt-sensitive hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(2):119-40.
1997: Budzikowski A S; Vahid-Ansari F; Robertson G S; Leenen F H
Patterns of neuronal activation during development of sodium sensitive hypertension in SHR.
Hypertension 1997;30(6):1572-7.
1997: Leenen F H; Wilson T W; Bolli P; Larochelle P; Myers M; Handa S P; Boileau G; Tanner J
Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring.
The Canadian journal of cardiology 1997;13(10):914-20.
1997: Huang B S; Yuan B; Leenen F H
Blockade of brain 'ouabain' prevents the impairment of baroreflexes in rats after myocardial infarction.
Circulation 1997;96(5):1654-9.
1997: Lear W; Ruzicka M; Leenen F H
ACE inhibitors and cardiac ACE mRNA in volume overload-induced cardiac hypertrophy.
The American journal of physiology 1997;273(2 Pt 2):H641-6.
1997: Song D; Harmsen E; Leenen F H
alpha- and beta-adrenoceptor blockade fail to prevent high sodium diet-induced left ventricular hypertrophy.
American journal of hypertension 1997;10(8):913-20.
1997: Ruzicka M; Leenen F H
Update on local cardiac renin-angiotensin system.
Current opinion in cardiology 1997;12(4):347-53.
1997: Huang B S; Sancho J M; Garcia-Robles R; Leenen F H
Sympathoexcitatory effect of hypothalamic/hypophysary inhibitory factor in rats.
Hypertension 1997;29(6):1291-5.
1997: White M; Leenen F H
Effects of age on cardiovascular responses to adrenaline in man.
British journal of clinical pharmacology 1997;43(4):407-14.
1997: Veerasingham S J; Leenen F H
Excitotoxic lesions of the ventral anteroventral third ventricle and pressor responses to central sodium, ouabain and angiotensin II.
Brain research 1997;749(1):157-60.
1997: Budzikowski A S; Leenen F H
Brain 'ouabain' in the median preoptic nucleus mediates sodium-sensitive hypertension in spontaneously hypertensive rats.
Hypertension 1997;29(2):599-605.
1996: Huang B S; Leenen F H
Brain "ouabain" and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive rats.
Hypertension 1996;28(6):1005-12.
1996: Leenen F H
Clinical relevance of 24 h blood pressure control by 1,4-dihydropyridines.
American journal of hypertension 1996;9(10 Pt 2):97S-104S; discussion 108S-109S.
1996: Leenen F H
Increased risk attributed to left ventricular hypertrophy in hypertension.
Current opinion in cardiology 1996;11(5):464-70.
1996: Huang B S; Leenen F H
Blockade of brain "ouabain" prevents sympathoexcitatory and pressor responses to high sodium in SHR.
The American journal of physiology 1996;271(1 Pt 2):H103-8.
1996: Leenen F H; Fourney A
Comparison of the effects of amlodipine and diltiazem on 24-hour blood pressure, plasma catecholamines, and left ventricular mass.
The American journal of cardiology 1996;78(2):203-7.
1996: Leenen F H; Fourney A; Notman G; Tanner J
Persistence of anti-hypertensive effect after 'missed doses' of calcium antagonist with long (amlodipine) vs short (diltiazem) elimination half-life.
British journal of clinical pharmacology 1996;41(2):83-8.
1996: Ruzicka M; Leenen F H
Relevance of 24 H blood pressure profile and sympathetic activity for outcome on short- versus long-acting 1,4-dihydropyridines.
American journal of hypertension 1996;9(1):86-94.
1996: Huang B S; Leenen F H
Sympathoexcitatory and pressor responses to increased brain sodium and ouabain are mediated via brain ANG II.
The American journal of physiology 1996;270(1 Pt 2):H275-80.
1995: Ruzicka M; Skarda V; Leenen F H
Effects of ACE inhibitors on circulating versus cardiac angiotensin II in volume overload-induced cardiac hypertrophy in rats.
Circulation 1995;92(12):3568-73.
1995: Leenen F H; Huang B S; Yu H; Yuan B
Brain 'ouabain' mediates sympathetic hyperactivity in congestive heart failure.
Circulation research 1995;77(5):993-1000.
1995: Abdelrahman A M; Harmsen E; Leenen F H
Dietary sodium and Na,K-ATPase activity in Dahl salt-sensitive versus salt-resistant rats.
Journal of hypertension 1995;13(5):517-22.
1995: Huang B S; Leenen F H
Brain 'ouabain,' sodium, and arterial baroreflex in spontaneously hypertensive rats.
Hypertension 1995;25(4 Pt 2):814-7.
1995: Huang B S; Leenen F H
Brain 'ouabain' and desensitization of arterial baroreflex by high sodium in Dahl salt-sensitive rats.
Hypertension 1995;25(3):372-6.
1995: Leenen F H; Davies R A; Fourney A
Role of cardiac beta 2-receptors in cardiac responses to exercise in cardiac transplant patients.
Circulation 1995;91(3):685-90.
1995: Huang B S; Leenen F H
Dietary Na+ and cardiopulmonary baroreflex control of renal sympathetic nerve activity in SHR.
The American journal of physiology 1995;268(1 Pt 2):H61-7.
1995: Ruzicka M; Leenen F H
Relevance of blockade of cardiac and circulatory angiotensin-converting enzyme for the prevention of volume overload-induced cardiac hypertrophy.
Circulation 1995;91(1):16-9.
1995: Leenen F H
Cardiac trophic stimuli and the transplanted heart.
Blood pressure. Supplement 1995;2():35-8.
1994: Leenen F H; Harmsen E; Yu H
Dietary sodium and central vs. peripheral ouabain-like activity in Dahl salt-sensitive vs. salt-resistant rats.
The American journal of physiology 1994;267(5 Pt 2):H1916-20.
1994: White M; Leenen F H
Aging and cardiovascular responsiveness to beta-agonist in humans: role of changes in beta-receptor responses versus baroreflex activity.
Clinical pharmacology and therapeutics 1994;56(5):543-53.
1994: Boer P H; Ruzicka M; Lear W; Harmsen E; Rosenthal J; Leenen F H
Stretch-mediated activation of cardiac renin gene.
The American journal of physiology 1994;267(4 Pt 2):H1630-6.
1994: Ruzicka M; Keeley F W; Leenen F H
The renin-angiotensin system and volume overload-induced changes in cardiac collagen and elastin.
Circulation 1994;90(4):1989-96.
1994: Ruzicka M; Yuan B; Leenen F H
Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats.
Circulation 1994;90(1):484-91.
1994: Huang B S; Huang X; Harmsen E; Leenen F H
Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats.
Hypertension 1994;23(6 Pt 2):1087-90.
1994: Schoemaker R G; Leenen F H; Harmsen E
Age-related increase in sensitivity for ischemic ATP breakdown in hypertrophic hearts of SHR normalized by enalapril.
Journal of molecular and cellular cardiology 1994;26(5):649-60.
1994: Huang B S; Leenen F H
Brain "ouabain" mediates the sympathoexcitatory and hypertensive effects of high sodium intake in Dahl salt-sensitive rats.
Circulation research 1994;74(4):586-95.
1994: Huang B S; Leenen F H
Dietary Na and baroreflex modulation of blood pressure and RSNA in normotensive vs. spontaneously hypertensive rats.
The American journal of physiology 1994;266(2 Pt 2):H496-502.
1994: Harmsen E; Schoemaker R; Yu J; Ruzicka M; Leenen F H
Sensitivity to ischaemic ATP breakdown in different models of cardiac hypertrophy in rats.
Journal of hypertension 1994;12(1):49-57.
1994: Leenen F H; Yuan B; Tsoporis J; Lee R M
Arterial hypertrophy and pressor responsiveness during development of hypertension in spontaneously hypertensive rats.
Journal of hypertension 1994;12(1):23-32.
1993: Tsoporis J; Fields N; Lee R M; Leenen F H
Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats.
Journal of hypertension 1993;11(12):1337-45.
1993: Ruzicka M; Leenen F H
Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats.
The American journal of physiology 1993;265(5 Pt 2):H1551-6.
1993: Leenen F H; Harmsen E; Yu H; Yuan B
Dietary sodium stimulates ouabainlike activity in adrenalectomized spontaneously hypertensive rats.
The American journal of physiology 1993;265(1 Pt 2):H421-4.
1993: Legault L; Ogilvie R I; Cardella C J; Leenen F H
Calcium antagonists in heart transplant recipients: effects on cardiac and renal function and cyclosporine pharmacokinetics.
The Canadian journal of cardiology 1993;9(5):398-404.
1993: Leenen F H; Harmsen E; Yu H; Ou C
Effects of dietary sodium on central and peripheral ouabain-like activity in spontaneously hypertensive rats.
The American journal of physiology 1993;264(6 Pt 2):H2051-5.
1993: Ruzicka M; Yuan B; Harmsen E; Leenen F H
The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats. Effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker.
Circulation 1993;87(3):921-30.
1993: Leenen F H; Huang B S; Harmsen E
Role of brain ouabain-like activity in the central effects of sodium in rats.
Journal of cardiovascular pharmacology 1993;22 Suppl 2():S72-4.
1992: Legault L; van Nguyen P; Holliwell D L; Leenen F H
Hemodynamic and plasma atrial natriuretic factor responses to cardiac volume loading in young versus older normotensive humans.
Canadian journal of physiology and pharmacology 1992;70(12):1549-54.
1992: Huang B S; Harmsen E; Yu H; Leenen F H
Brain ouabain-like activity and the sympathoexcitatory and pressor effects of central sodium in rats.
Circulation research 1992;71(5):1059-66.
1992: Leenen F H; Klement G; Yuan B
Dietary sodium restriction and pressor responsiveness to tyramine in spontaneously hypertensive rats.
Journal of hypertension 1992;10(9):929-37.
1992: Leenen F H; Yuan B
Dietary sodium and the antihypertensive effect of nifedipine in spontaneously hypertensive rats.
American journal of hypertension 1992;5(8):515-9.
1992: Yuan B; Leenen F H
Chronic arterial vasodilation, central hemodynamics, and cardiac hypertrophy in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1992;19(6):922-8.
1992: Huang B S; Leenen F H
Dietary Na, age, and baroreflex control of heart rate and renal sympathetic nerve activity in rats.
The American journal of physiology 1992;262(5 Pt 2):H1441-8.
1992: Wilczynski E A; Yuan B; Leenen F H
Dietary sodium restriction and the development of two-kidney, one-clip hypertension in young versus adult rats.
Canadian journal of physiology and pharmacology 1992;70(4):452-7.
1992: Harmsen E; Leenen F H
Dietary sodium induced cardiac hypertrophy.
Canadian journal of physiology and pharmacology 1992;70(4):580-6.
1992: Levine M A; Leenen F H
Role of vagal activity in the cardiovascular responses to phenylephrine in man.
British journal of clinical pharmacology 1992;33(3):333-6.
1992: Leenen F H; Holliwell D L
Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.
The American journal of cardiology 1992;69(6):639-45.
1992: Huang B S; Leenen F H
Brain ouabain and central effects of dietary sodium in spontaneously hypertensive rats.
Circulation research 1992;70(2):430-7.
1991: von Nguyen P; Holliwell D L; Davis A; Tasker T C; Leenen F H
Effects of the potassium channel activator, cromakalim, on arterial and cardiac responses to norepinephrine, angiotensin II, and isoproterenol in normotensive men.
Journal of cardiovascular pharmacology 1991;18(6):797-806.
1991: Yuan B X; Leenen F H
Dietary sodium intake and left ventricular hypertrophy in normotensive rats.
The American journal of physiology 1991;261(5 Pt 2):H1397-401.
1991: Leenen F H; Strauss M H; Chan Y K; Burns R J
Cardiac effects of prazosin in chronic aortic insufficiency.
The Canadian journal of cardiology 1991;7(6):265-9.
1991: Tsoporis J; Fields N; Lee R M; Leenen F H
Arterial vasodilation and cardiovascular structural changes in normotensive rats.
The American journal of physiology 1991;260(6 Pt 2):H1944-52.
1991: Fields N G; Yuan B X; Leenen F H
Sodium-induced cardiac hypertrophy. Cardiac sympathetic activity versus volume load.
Circulation research 1991;68(3):745-55.
1991: Leenen F H; Harmsen E
Antihypertensive drugs and cardiac trophic mechanisms.
Journal of cardiovascular pharmacology 1991;17 Suppl 2():S50-7.
1991: Tsoporis J; Fields N; Lee R M; Leenen F H
Opposite effects of arterial vasodilators on cardiac vs. arterial hypertrophy and sympathetic activity in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1991;17 Suppl 2():S169-71.
1991: Tsoporis J; Fields N; Leenen F H
Contrasting effects of calcium antagonists vs. arterial vasodilators on cardiac anatomy and sympathetic activity in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1991;17 Suppl 2():S166-8.
1990: Leenen F H; Tsoporis J
Cardiac volume load as a determinant of the response of cardiac mass to antihypertensive therapy.
European heart journal 1990;11 Suppl G():100-6.
1990: Van Nguyen P; Cleroux J; Peterson M; Leenen F H
Beta-blockade with intrinsic sympathetic activity modifies favorably exercise-induced changes in plasma lipoproteins.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(2):485-9.
1990: Leenen F H; Burns R J; Myers M G; Frankel D
Effects of nifedipine versus hydralazine on sympathetic activity and cardiac function in patients with hypertension persisting on diuretic plus beta-blocker therapy.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1990;4(2):499-504.
1990: Leenen F H; Klement G
Dietary sodium restriction and blood pressure response to sympathetic blockade in young versus adolescent spontaneously hypertensive rats.
Canadian journal of physiology and pharmacology 1990;68(1):46-50.
1989: Roy L F; East D S; Browning F M; Shaw D; Ogilvie R I; Cardella C; Leenen F H
Short-term effects of calcium antagonists on hemodynamics and cyclosporine pharmacokinetics in heart-transplant and kidney-transplant patients.
Clinical pharmacology and therapeutics 1989;46(6):657-67.
1989: Fields N; Tsoporis J; Leenen F H
Differential effects of the calcium antagonist, nisoldipine, versus the arterial vasodilator, minoxidil, on ventricular anatomy, intravascular volume, and sympathetic activity in rats.
Journal of cardiovascular pharmacology 1989;14(6):826-35.
1989: Reeves R A; Boer W H; DeLeve L; Leenen F H
Beta-blockade disappearance rate predicts beta-adrenergic hypersensitivity.
Clinical pharmacology and therapeutics 1989;46(3):279-90.
1989: Tsoporis J; Yuan B X; Leenen F H
Arterial vasodilators, cardiac volume load, and cardiac hypertrophy in normotensive rats.
The American journal of physiology 1989;256(3 Pt 2):H876-80.
1989: Chapman K R; Galko B M; Smith D L; Leenen F H
Effects of atenolol vs diltiazem on the haemodynamic effects of an inhaled beta 2-adrenoceptor agonist.
British journal of clinical pharmacology 1989;27(2):268-71.
1989: Cleroux J; Van Nguyen P; Taylor A W; Leenen F H
Effects of beta 1- vs. beta 1 + beta 2-blockade on exercise endurance and muscle metabolism in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(2):548-54.
1989: Roy L F; Ogilvie R I; Larochelle P; Hamet P; Leenen F H
Cardiac and vascular effects of atrial natriuretic factor and sodium nitroprusside in healthy men.
Circulation 1989;79(2):383-92.
1989: Leenen F H; Toal C B
Dietary sodium restriction and the renin-angiotensin system in young spontaneously hypertensive rats.
Journal of hypertension 1989;7(1):57-61.
1989: Levine M A; Leenen F H
Role of beta 1-receptors and vagal tone in cardiac inotropic and chronotropic responses to a beta 2-agonist in humans.
Circulation 1989;79(1):107-15.
1989: Leenen F H
Left ventricular hypertrophy in hypertensive patients.
The American journal of medicine 1989;86(1B):63-5.
1989: Leenen F H
Functional significance of B1- versus B2-receptors for cardiac inotropic and chronotropic responses in man.
Clinical and experimental hypertension. Part A, Theory and practice 1989;11 Suppl 1():43-58.
1988: Leenen F H; Klement G
Dietary sodium restriction and blood pressure response to alpha-receptor blockade in young spontaneously hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S202-4.
1988: Leenen F H; Smith D L; Unger W P
Topical minoxidil: cardiac effects in bald man.
British journal of clinical pharmacology 1988;26(4):481-5.
1988: Cleroux J; Leenen F H
Effects of beta-blockade on muscle metabolism during prolonged exercise. A short review.
American journal of hypertension 1988;1(3 Pt 3):290S-294S.
1988: Leenen F H; Chan Y K; Smith D L; Reeves R A
Epinephrine and left ventricular function in humans: effects of beta-1 vs nonselective beta-blockade.
Clinical pharmacology and therapeutics 1988;43(5):519-28.
1988: Tsoporis J; Leenen F H
Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats.
Hypertension 1988;11(4):376-86.
1988: Leenen F H; Smith D L; Farkas R M; Boer W H; Reeves R A; Marquez-Julio A
Cardiovascular effects of indapamide in hypertensive patients with or without renal failure. A dose-response curve.
The American journal of medicine 1988;84(1B):76-85.
1988: Nguyen P V; Smith D L; Leenen F H
Acute volume loading, atrial natriuretic peptide release and cardiac function in healthy men. Effects of beta-blockade.
Life sciences 1988;43(10):821-30.
1987: Leenen F H; Reeves R A
Beta-receptor-mediated increase in venous return in humans.
Canadian journal of physiology and pharmacology 1987;65(8):1658-65.
1987: Leenen F H; Smith D L; Farkas R M; Reeves R A; Marquez-Julio A
Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans.
The American journal of medicine 1987;82(5):969-78.
1987: Roy L F; Leenen F H
Therapeutic rounds. Nonsteroidal anti-inflammatory drugs.
Clinical therapeutics 1987;9(6):577, 690-2.
1985: Wilczynski E A; Leenen F H
Age dependency of the effects of dietary sodium restriction on blood pressure in spontaneously hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1985;3(3):S435-7.
1984: Reeves R A; Boer W H; DeLeve L; Leenen F H
Nonselective beta-blockade enhances pressor responsiveness to epinephrine, norepinephrine, and angiotensin II in normal man.
Clinical pharmacology and therapeutics 1984;35(4):461-6.
1983: Leenen F H; Smith D L; Boer W H; Marquez-Julio A
Diuretic and cardiovascular effects of indapamide in hypertensive subjects: a dose-response curve.
Current medical research and opinion 1983;8 Suppl 3():47-52.

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