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Frans Leenen

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J George Fodor; Frans Leenen; Eftyhia Helis; Penelope Turton
2006 Ontario Survey on the Prevalence and Control of Hypertension (ON-BP): rationale and design of a community-based cross-sectional survey.
Frans Leenen; Jean Dumais; Natalie H McInnis; Penelope Turton; Lori Stratychuk; Kathleen Nemeth; Margaret Moy Lum-Kwong; George Fodor
Results of the Ontario survey on the prevalence and control of hypertension.
Binhui Liang; Frans Leenen
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.

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All Publications

2008: J George Fodor; Frans Leenen; Eftyhia Helis; Penelope Turton
2006 Ontario Survey on the Prevalence and Control of Hypertension (ON-BP): rationale and design of a community-based cross-sectional survey.
The Canadian journal of cardiology 2008;24(6):503-5.
2008: Frans Leenen; Jean Dumais; Natalie H McInnis; Penelope Turton; Lori Stratychuk; Kathleen Nemeth; Margaret Moy Lum-Kwong; George Fodor
Results of the Ontario survey on the prevalence and control of hypertension.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2008;178(11):1441-9.
2008: Binhui Liang; Frans Leenen
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.
Journal of cardiovascular pharmacology 2008;51(5):457-66.
2008: Martin G Myers; Natalie H McInnis; George J Fodor; Frans Leenen
Comparison between an automated and manual sphygmomanometer in a population survey.
American journal of hypertension 2008;21(3):280-3.
2007: Marcel Ruzicka; Elizabeth Coletta; Frans Leenen
Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients?
American journal of hypertension 2007;20(11):1202-8.
2007: B Liang; Frans Leenen
Prevention of salt induced hypertension and fibrosis by angiotensin converting enzyme inhibitors in Dahl S rats.
British journal of pharmacology 2007;152(6):903-14.
2007: Bing S Huang; Monir Ahmad; Junhui Tan; Frans Leenen
Sympathetic hyperactivity and cardiac dysfunction post-MI: different impact of specific CNS versus general AT1 receptor blockade.
Journal of molecular and cellular cardiology 2007;43(4):479-86.
2007: Frédérique Tesson; Frans Leenen
Still building on candidate-gene strategy in hypertension?
Hypertension 2007;50(4):607-8.
2007: Frans Leenen
Brain mechanisms contributing to sympathetic hyperactivity and heart failure.
Circulation research 2007;101(3):221-3.
2007: Frans Leenen; Elizabeth Coletta; Ross A Davies
Prevention of renal dysfunction and hypertension by amlodipine after heart transplant.
The American journal of cardiology 2007;100(3):531-5.
2007: Bing S Huang; Monir Ahmad; Alan Y Deng; Frans Leenen
Neuronal responsiveness to central Na+ in 2 congenic strains of Dahl salt-sensitive rats.
Hypertension 2007;49(6):1315-20.
2007: Frans Leenen; Anne Fourney; Elizabeth Coletta; Roselyn White
Effects of hypertension on cardiovascular responses to epinephrine in humans.
American journal of physiology. Heart and circulatory physiology 2007;292(6):H3025-31.
2007: Marlene F Shehata; Frans Leenen; Frédérique Tesson
Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats.
BMC genetics 2007;8():35.
2007: Martin G Myers; Frans Leenen
The impact of one or two missed doses on the duration of action of combined perindopril and indapamide.
Journal of human hypertension 2007;21(1):86-93.
2006: Frans Leenen; Chuke Nwachuku; Henry R Black; William Cushman; Barry R Davis; Lara M Simpson; Michael H Alderman; Steven A Atlas; Jan Basile; Aloysius B Cuyjet; Richard Dart; James V Felicetta; Richard H Grimm; L Julian Haywood; Syed Z A Jafri; Michael A Proschan; Udho Thadani; Paul K Whelton; Jackson T Wright
Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial.
Hypertension 2006;48(3):374-84.
2006: Bing S Huang; Warren J Cheung; Hao Wang; Junhui Tan; Roselyn A White; Frans Leenen
Activation of brain renin-angiotensin-aldosterone system by central sodium in Wistar rats.
American journal of physiology. Heart and circulatory physiology 2006;291(3):H1109-17.
2006: Marcel Ruzicka; Frans Leenen
Moving beyond guidelines: are report cards the answer to high rates of uncontrolled hypertension?
Current hypertension reports 2006;8(4):324-9.
2006: Warren J Cheung; Mary-Anne H Kent; Esraa El-Shahat; Hongwei Wang; Junhui Tan; Roselyn White; Frans Leenen
Central and peripheral renin-angiotensin systems in ouabain-induced hypertension.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H624-30.
2006: Bing S Huang; Md. Shahrier Amin; Frans Leenen
The central role of the brain in salt-sensitive hypertension.
Current opinion in cardiology 2006;21(4):295-304.
2006: Stephanie A Dean; Junhui Tan; Roselyn White; Edward O'Brien; Frans Leenen
Regulation of components of the brain and cardiac renin-angiotensin systems by 17beta-estradiol after myocardial infarction in female rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(1):R155-62.
2006: Barry R Davis; Linda B Piller; Jeffrey A Cutler; Curt D Furberg; Kay Dunn; Stanley Franklin; David Goff; Frans Leenen; Syed Mohiuddin; Vasilios Papademetriou; Michael A Proschan; Allan Ellsworth; John Golden; Pedro J Colon; Richard S Crow
Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Circulation 2006;113(18):2201-10.
2006: Martin G Myers; Frans Leenen
Persistence of the antihypertensive effect of low-dose combination therapy in mild hypertension.
Blood pressure 2006;15(6):325-32.
2006: Frans Leenen; Elizabeth Coletta; Roselyn White
Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release.
Journal of hypertension 2006;24(1):177-84.
2005: Martin MacKinnon; Frans Leenen; Marcel Ruzicka
Does ALLHAT change the management of hypertension in chronic kidney disease?
Current hypertension reports 2005;7(6):474-83.
2005: Md. Shahrier Amin; Hong-Wei Wang; Erona Reza; Stewart C Whitman; Balwant S Tuana; Frans Leenen
Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(6):R1787-97.
2005: Avtar Lal; John P Veinot; Detlev Ganten; Frans Leenen
Prevention of cardiac remodeling after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Journal of molecular and cellular cardiology 2005;39(3):521-9.
2005: Paul K Whelton; Joshua I Barzilay; William Cushman; Barry R Davis; Ekambaram Iiamathi; John B Kostis; Frans Leenen; Gail T Louis; Karen L Margolis; David E Mathis; Jamaluddin Moloo; Chuke Nwachuku; Deborah Panebianco; David Parish; Sara Pressel; Debra L Simmons; Udho Thadani
Clinical outcomes in antihypertensive treatment of type 2 diabetes, impaired fasting glucose concentration, and normoglycemia: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Archives of internal medicine 2005;165(12):1401-9.
2005: Frans Leenen; Elizabeth Coletta; Anne Fourney; Roselyn White
Aging and cardiac responses to epinephrine in humans: role of neuronal uptake.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2498-503.
2005: Bing S Huang; Frans Leenen
Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2491-7.
2005: Jackson T Wright; J Kay Dunn; Jeffrey A Cutler; Barry R Davis; William Cushman; Charles E Ford; L Julian Haywood; Frans Leenen; Karen L Margolis; Vasilios Papademetriou; Jeffrey L Probstfield; Paul K Whelton; Gabriel B Habib
Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril.
JAMA : the journal of the American Medical Association 2005;293(13):1595-608.
2005: Stephanie A Dean; Junhui Tan; Edward O'Brien; Frans Leenen
17beta-estradiol downregulates tissue angiotensin-converting enzyme and ANG II type 1 receptor in female rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(3):R759-66.
2005: Junhui Tan; Jun Ming Wang; Frans Leenen
Inhibition of brain angiotensin-converting enzyme by peripheral administration of trandolapril versus lisinopril in Wistar rats.
American journal of hypertension 2005;18(2 Pt 1):158-64.
2005: Bing S Huang; Hao Wang; Frans Leenen
Chronic central infusion of aldosterone leads to sympathetic hyperreactivity and hypertension in Dahl S but not Dahl R rats.
American journal of physiology. Heart and circulatory physiology 2005;288(2):H517-24.
2004: Avtar Lal; John P Veinot; Frans Leenen
Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats.
Cardiovascular research 2004;64(3):437-47.
2004: Frans Leenen
ALLHAT: what has it taught us so far?
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2004;171(7):719-20.
2004: Bing S Huang; Bruce N Van Vliet; Frans Leenen
Increases in CSF [Na+] precede the increases in blood pressure in Dahl S rats and SHR on a high-salt diet.
American journal of physiology. Heart and circulatory physiology 2004;287(3):H1160-6.
2004: Mary-Anne H Kent; Bing S Huang; James W Van Huysse; Frans Leenen
Brain Na+,K+-ATPase isozyme activity and protein expression in ouabain-induced hypertension.
Brain research 2004;1018(2):171-80.
2004: Frans Leenen
Blood pressure lowering, not vascular mechanism of action, is the primary determinant of clinical outcome.
The Canadian journal of cardiology 2004;20 Suppl B():77B-82B.
2004: Marcel Ruzicka; Elizabeth Coletta; John Floras; Frans Leenen
Effects of low-dose nifedipine GITS on sympathetic activity in young and older patients with hypertension.
Journal of hypertension 2004;22(5):1039-44.
2004: Junhui Tan; Hao Wang; Frans Leenen
Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats.
American journal of physiology. Heart and circulatory physiology 2004;286(5):H1665-71.
2004: Hao Wang; Bing S Huang; Detlev Ganten; Frans Leenen
Prevention of sympathetic and cardiac dysfunction after myocardial infarction in transgenic rats deficient in brain angiotensinogen.
Circulation research 2004;94(6):843.
2003: Hao Wang; Bing S Huang; Frans Leenen
Brain sodium channels and ouabainlike compounds mediate central aldosterone-induced hypertension.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2516-23.
2003: Hao Wang; Roselyn White; Frans Leenen
Stimulation of brain Na+ channels by FMRFamide in Dahl SS and SR rats.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H2013-8.
2003: Jun Ming Wang; Shereeni J Veerasingham; Junhui Tan; Frans Leenen
Effects of high salt intake on brain AT1 receptor densities in Dahl rats.
American journal of physiology. Heart and circulatory physiology 2003;285(5):H1949-55.
2003: Bing S Huang; Frans Leenen
Sympathoinhibitory and depressor effects of amlodipine in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2003;42(2):153-60.
2003: Hao Wang; Frans Leenen
Brain sodium channels and central sodium-induced increases in brain ouabain-like compound and blood pressure.
Journal of hypertension 2003;21(8):1519-24.
2003: Avtar Lal; John P Veinot; Frans Leenen
Prevention of high salt diet-induced cardiac hypertrophy and fibrosis by spironolactone.
American journal of hypertension 2003;16(4):319-23.
2003: Jun Ming Wang; Junhui Tan; Frans Leenen
Central nervous system blockade by peripheral administration of AT1 receptor blockers.
Journal of cardiovascular pharmacology 2003;41(4):593-9.
2002: Marcel Ruzicka; Frans Leenen
Combination therapy as first-line treatment of arterial hypertension.
The Canadian journal of cardiology 2002;18(12):1317-27.
2002: Frans Leenen; Martin G Myers; Campbell D Joyner; Corey Toal
Differential effects of once-daily antihypertensive drugs on blood pressure, left ventricular mass and sympathetic activity: Nifedipine-GITS versus felodipine-ER versus enalapril.
The Canadian journal of cardiology 2002;18(12):1285-93.
2002: Jun Ming Wang; Dirk Slembrouck; Junhui Tan; Lutgarde Arckens; Frans Leenen; Pierre J Courtoy; Werner P De Potter
Presence of cellular renin-angiotensin system in chromaffin cells of bovine adrenal medulla.
American journal of physiology. Heart and circulatory physiology 2002;283(5):H1811-8.
2002: Michael K Chow; Qiming Shao; Bin Ren; Frans Leenen; James W Van Huysse
Changes in brain Na, K-ATPase isoform expression and enzymatic activity after aortic constriction.
Brain research 2002;944(1-2):124-34.
2002: Hao Wang; Frans Leenen
Brain sodium channels mediate increases in brain "ouabain" and blood pressure in Dahl S rats.
Hypertension 2002;40(1):96-100.
2002: Frans Leenen
Conflicts of interest and libel action.
The New England journal of medicine 2002;346(24):1919-20; author reply 1919-20.
2002: Finlay A McAlister; Kelly B Zarnke; Norman R C Campbell; Ross D Feldman; Mitchell Levine; Jeffrey L Mahon; Steven A Grover; Richard Z Lewanczuk; Frans Leenen; Sheldon Tobe; Marcel Lebel; James Stone; Ernesto L Schiffrin; Simon W Rabkin; Richard I Ogilvie; Pierre Larochelle; Charlotte Jones; George Honos; George Fodor; Ellen Burgess; Pavel Hamet; Robert Herman; Jane Irvine; Bruce Culleton; James M Wright
The 2001 Canadian recommendations for the management of hypertension: Part two--Therapy.
The Canadian journal of cardiology 2002;18(6):625-41.
2002: Frans Leenen; Marcel Ruzicka; Bing S Huang
The brain and salt-sensitive hypertension.
Current hypertension reports 2002;4(2):129-35.
2002: Ashley S Izzard; Anthony M Heagerty; Frans Leenen
The amplifier hypothesis: persisting dissent.
Journal of hypertension 2002;20(3):375-7.
2002: Bing S Huang; Frans Leenen
Brain amiloride-sensitive Phe-Met-Arg-Phe-NH(2)--gated Na(+) channels and Na(+)-induced sympathoexcitation and hypertension.
Hypertension 2002;39(2 Pt 2):557-61.
2001: Jackson T Wright; William Cushman; Barry R Davis; Joshua I Barzilay; Pedro J Colon; D Egan; T Lucente; Chuke Nwachuku; Sara Pressel; Frans Leenen; Joseph P Frolkis; R Letterer; S Walsh; Jonathan Tobin; G E Deger
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): clinical center recruitment experience.
Controlled clinical trials 2001;22(6):659-73.
2001: Frans Leenen; Roselyn White; B Yuan
Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system.
American journal of physiology. Heart and circulatory physiology 2001;281(6):H2410-6.
2001: Bing S Huang; Hao Wang; Frans Leenen
Enhanced sympathoexcitatory and pressor responses to central Na+ in Dahl salt-sensitive vs. -resistant rats.
American journal of physiology. Heart and circulatory physiology 2001;281(5):H1881-9.
2001: J Zhang; Frans Leenen
Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin II and sodium.
Canadian journal of physiology and pharmacology 2001;79(10):861-7.
2001: Adam Budzikowski; Frans Leenen
ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1210-6.
2001: Frans Leenen; Marcel Ruzicka; Bing S Huang
Central sympathoinhibitory effects of calcium channel blockers.
Current hypertension reports 2001;3(4):314-21.
2001: Finlay A McAlister; Mitchell Levine; Kelly B Zarnke; Norman Campbell; Richard Z Lewanczuk; Frans Leenen; Simon Rabkin; J M Wright; J Stone; Ross D Feldman; Marcel Lebel; George Honos; George Fodor; Ellen Burgess; Sheldon Tobe; Pavel Hamet; R Herman; J Irvine; Bruce Culleton; R Petrella; Rhian M Touyz
The 2000 Canadian recommendations for the management of hypertension: Part one--therapy.
The Canadian journal of cardiology 2001;17(5):543-59.
2001: Frans Leenen; B Yuan
Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade.
Hypertension 2001;37(3):981-4.
2001: J Zhang; Frans Leenen
AT(1) receptor blockers prevent sympathetic hyperactivity and hypertension by chronic ouabain and hypertonic saline.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1318-23.
2001: Bing S Huang; Detlev Ganten; Frans Leenen
Responses to central Na(+) and ouabain are attenuated in transgenic rats deficient in brain angiotensinogen.
Hypertension 2001;37(2 Pt 2):683-6.
2001: Frans Leenen; B Yuan
Mortality after coronary artery occlusion in different models of cardiac hypertrophy in rats.
Hypertension 2001;37(2):209-15.
2001: Marcel Ruzicka; Frans Leenen
Monotherapy versus combination therapy as first line treatment of uncomplicated arterial hypertension.
Drugs 2001;61(7):943-54.
2001: X Zhao; Roselyn White; Bing S Huang; James W Van Huysse; Frans Leenen
High salt intake and the brain renin--angiotensin system in Dahl salt-sensitive rats.
Journal of hypertension 2001;19(1):89-98.
2000: Bing S Huang; Piotr P Murzenok; Frans Leenen
Sympathoinhibitory and depressor responses to long-term infusion of nifedipine in spontaneously hypertensive rats on high-salt diet.
Journal of cardiovascular pharmacology 2000;36(6):704-10.
2000: Shereeni J Veerasingham; F Vahid-Ansari; Frans Leenen
Neuronal Fos-like immunoreactivity in ouabain-induced hypertension.
Brain research 2000;876(1-2):17-21.
2000: R Kumarathasan; Frans Leenen
Effects of soybean lipoxygenase on Na+/K+-ATPase activity in vitro.
Canadian journal of physiology and pharmacology 2000;78(9):691-5.
2000: X Zhao; Roselyn White; James W Van Huysse; Frans Leenen
Cardiac hypertrophy and cardiac renin-angiotensin system in Dahl rats on high salt intake.
Journal of hypertension 2000;18(9):1319-26.
2000: Frans Leenen; J Tanner; C F McNally
Antihypertensive efficacy of the ACE-inhibitor perindopril in the elderly.
Journal of human hypertension 2000;14(5):321-5.
2000: Geeta Kala; R Kumarathasan; L Peng; Frans Leenen; Leif Hertz
Stimulation of Na+,K+-ATPase activity, increase in potassium uptake, and enhanced production of ouabain-like compounds in ammonia-treated mouse astrocytes.
Neurochemistry international 2000;36(3):203-11.
2000: Piotr P Murzenok; Bing S Huang; Frans Leenen
Sympathoinhibition by central and peripheral infusion of nifedipine in spontaneously hypertensive rats.
Hypertension 2000;35(2):631-6.
2000: R Kumarathasan; Frans Leenen
Is ATP a substrate for 15-lipoxygenase?
Biochemistry and cell biology = Biochimie et biologie cellulaire 2000;78(2):87-91.
2000: Bing S Huang; B Yuan; Frans Leenen
Chronic blockade of brain "ouabain" prevents sympathetic hyper-reactivity and impairment of acute baroreflex resetting in rats with congestive heart failure.
Canadian journal of physiology and pharmacology 2000;78(1):45-53.
1999: Ashley S Izzard; Anthony M Heagerty; Frans Leenen
The amplifier hypothesis: permission to dissent?
Journal of hypertension 1999;17(12 Pt 1):1667-9.
1999: Frans Leenen; B Yuan; Bing S Huang
Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction.
The American journal of physiology 1999;277(5 Pt 2):H1786-92.
1999: K W Tan; Frans Leenen
Persistence of anti-hypertensive effect after missed dose of perindopril.
British journal of clinical pharmacology 1999;48(4):628-30.
1999: Bing S Huang; M Kudlac; R Kumarathasan; Frans Leenen
Digoxin prevents ouabain and high salt intake-induced hypertension in rats with sinoaortic denervation.
Hypertension 1999;34(4 Pt 2):733-8.
1999: Marcel Ruzicka; B Yuan; Frans Leenen
Blockade of AT(1) receptors and Na(+)/H(+) exchanger and LV dysfunction after myocardial infarction in rats.
The American journal of physiology 1999;277(2 Pt 2):H610-6.
1999: Frans Leenen
Calcium antagonists "some agents lower blood pressure and still put the heart at risk"?
Clinical and experimental hypertension (New York, N.Y. : 1993) 1999;21(5-6):823-34.
1999: Bing S Huang; Frans Leenen
Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats.
Hypertension 1999;34(1):107-12.
1999: J G Fodor; B Whitmore; Frans Leenen; Pierre Larochelle
Lifestyle modifications to prevent and control hypertension. 5. Recommendations on dietary salt. Canadian Hypertension Society, Canadian Coalition for High Blood Pressure Prevention and Control, Laboratory Centre for Disease Control at Health Canada, Heart and Stroke Foundation of Canada.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;160(9 Suppl):S29-34.
1999: Frans Leenen
Intermittent blood pressure control: potential consequences for outcome.
The Canadian journal of cardiology 1999;15 Suppl C():13C-18C.
1999: Weiguo Zhang; Bing S Huang; Frans Leenen
Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction.
The American journal of physiology 1999;276(5 Pt 2):H1608-15.
1999: Frans Leenen
Cardiovascular consequences of sympathetic hyperactivity.
The Canadian journal of cardiology 1999;15 Suppl A():2A-7A.
1999: M White; Anne Fourney; E Mikes; Frans Leenen
Effects of age and hypertension on cardiac responses to the alpha1-agonist phenylephrine in humans.
American journal of hypertension 1999;12(2 Pt 1):151-8.
1999: Ross D Feldman; Norman Campbell; Pierre Larochelle; Peter Bolli; Ellen Burgess; SG Carruthers; J S Floras; R Brian Haynes; George Honos; Frans Leenen; L A Leiter; A G Logan; Martin G Myers; J David Spence; Kelly B Zarnke
1999 Canadian recommendations for the management of hypertension. Task Force for the Development of the 1999 Canadian Recommendations for the Management of Hypertension.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 1999;161 Suppl 12():S1-17.
1999: Bing S Huang; Frans Leenen
Sympathoinhibitory effects of central nifedipine in spontaneously hypertensive rats on high versus regular sodium intake.
Hypertension 1999;33(1):32-5.
1999: Frans Leenen; V Skarda; B Yuan; Roselyn White
Changes in cardiac ANG II postmyocardial infarction in rats: effects of nephrectomy and ACE inhibitors.
The American journal of physiology 1999;276(1 Pt 2):H317-25.
1999: Shereeni J Veerasingham; Frans Leenen
Ouabain- and central sodium-induced hypertension depend on the ventral anteroventral third ventricle region.
The American journal of physiology 1999;276(1 Pt 2):H63-70.
1998: Bing S Huang; Frans Leenen
Both brain angiotensin II and "ouabain" contribute to sympathoexcitation and hypertension in Dahl S rats on high salt intake.
Hypertension 1998;32(6):1028-33.
1998: F Vahid-Ansari; Frans Leenen
Pattern of neuronal activation in rats with CHF after myocardial infarction.
The American journal of physiology 1998;275(6 Pt 2):H2140-6.
1998: Frans Leenen; R A Davies; Anne Fourney
Catecholamines and heart function in heart transplant patients: effects of beta1- versus nonselective beta-blockade.
Clinical pharmacology and therapeutics 1998;64(5):522-35.
1998: Frans Leenen
Regression of cardiac hypertrophy by 1,4 dihydropyridines in hypertensive patients.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1998;16(5):S9-15.
1998: James W Van Huysse; Frans Leenen
Role of endogenous brain "ouabain" in the sympathoexcitatory and pressor effects of sodium.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(5-6):657-67.
1998: Adam Budzikowski; F Vahid-Ansari; Frans Leenen
Chronic activation of brain areas by high-sodium diet in Dahl salt-sensitive rats.
The American journal of physiology 1998;274(6 Pt 2):H2046-52.
1998: Frans Leenen; B Yuan
Dietary-sodium-induced cardiac remodeling in spontaneously hypertensive rat versus Wistar-Kyoto rat.
Journal of hypertension 1998;16(6):885-92.
1998: M White; Anne Fourney; Frans Leenen
Age, hypertension, and cardiac responses to beta-agonist in humans.
Clinical pharmacology and therapeutics 1998;63(6):663-71.
1998: james/jim Tsoporis; F W Keeley; R M Lee; Frans Leenen
Arterial vasodilation and vascular connective tissue changes in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1998;31(6):960-2.
1998: Bing S Huang; Shereeni J Veerasingham; Frans Leenen
Brain "ouabain," ANG II, and sympathoexcitation by chronic central sodium loading in rats.
The American journal of physiology 1998;274(4 Pt 2):H1269-76.
1998: Adam Budzikowski; Bing S Huang; Frans Leenen
Brain "ouabain", a neurosteroid, mediates sympathetic hyperactivity in salt-sensitive hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) 1998;20(2):119-40.
1997: Adam Budzikowski; F Vahid-Ansari; G S Robertson; Frans Leenen
Patterns of neuronal activation during development of sodium sensitive hypertension in SHR.
Hypertension 1997;30(6):1572-7.
1997: Frans Leenen; Thomas W Wilson; Peter Bolli; Pierre Larochelle; M Myers; S P Handa; G Boileau; J Tanner
Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring.
The Canadian journal of cardiology 1997;13(10):914-20.
1997: Bing S Huang; B Yuan; Frans Leenen
Blockade of brain 'ouabain' prevents the impairment of baroreflexes in rats after myocardial infarction.
Circulation 1997;96(5):1654-9.
1997: W Lear; Marcel Ruzicka; Frans Leenen
ACE inhibitors and cardiac ACE mRNA in volume overload-induced cardiac hypertrophy.
The American journal of physiology 1997;273(2 Pt 2):H641-6.
1997: D Song; E Harmsen; Frans Leenen
alpha- and beta-adrenoceptor blockade fail to prevent high sodium diet-induced left ventricular hypertrophy.
American journal of hypertension 1997;10(8):913-20.
1997: Marcel Ruzicka; Frans Leenen
Update on local cardiac renin-angiotensin system.
Current opinion in cardiology 1997;12(4):347-53.
1997: Bing S Huang; J M Sancho; R Garcia-Robles; Frans Leenen
Sympathoexcitatory effect of hypothalamic/hypophysary inhibitory factor in rats.
Hypertension 1997;29(6):1291-5.
1997: M White; Frans Leenen
Effects of age on cardiovascular responses to adrenaline in man.
British journal of clinical pharmacology 1997;43(4):407-14.
1997: Shereeni J Veerasingham; Frans Leenen
Excitotoxic lesions of the ventral anteroventral third ventricle and pressor responses to central sodium, ouabain and angiotensin II.
Brain research 1997;749(1):157-60.
1997: Adam Budzikowski; Frans Leenen
Brain 'ouabain' in the median preoptic nucleus mediates sodium-sensitive hypertension in spontaneously hypertensive rats.
Hypertension 1997;29(2):599-605.
1996: Bing S Huang; Frans Leenen
Brain "ouabain" and angiotensin II in salt-sensitive hypertension in spontaneously hypertensive rats.
Hypertension 1996;28(6):1005-12.
1996: Frans Leenen
Clinical relevance of 24 h blood pressure control by 1,4-dihydropyridines.
American journal of hypertension 1996;9(10 Pt 2):97S-104S; discussion 108S-109S.
1996: Frans Leenen
Increased risk attributed to left ventricular hypertrophy in hypertension.
Current opinion in cardiology 1996;11(5):464-70.
1996: Frans Leenen; Anne Fourney
Comparison of the effects of amlodipine and diltiazem on 24-hour blood pressure, plasma catecholamines, and left ventricular mass.
The American journal of cardiology 1996;78(2):203-7.
1996: Bing S Huang; Frans Leenen
Blockade of brain "ouabain" prevents sympathoexcitatory and pressor responses to high sodium in SHR.
The American journal of physiology 1996;271(1 Pt 2):H103-8.
1996: Frans Leenen; Anne Fourney; G Notman; J Tanner
Persistence of anti-hypertensive effect after 'missed doses' of calcium antagonist with long (amlodipine) vs short (diltiazem) elimination half-life.
British journal of clinical pharmacology 1996;41(2):83-8.
1996: Marcel Ruzicka; Frans Leenen
Relevance of 24 H blood pressure profile and sympathetic activity for outcome on short- versus long-acting 1,4-dihydropyridines.
American journal of hypertension 1996;9(1):86-94.
1996: Bing S Huang; Frans Leenen
Sympathoexcitatory and pressor responses to increased brain sodium and ouabain are mediated via brain ANG II.
The American journal of physiology 1996;270(1 Pt 2):H275-80.
1995: Marcel Ruzicka; V Skarda; Frans Leenen
Effects of ACE inhibitors on circulating versus cardiac angiotensin II in volume overload-induced cardiac hypertrophy in rats.
Circulation 1995;92(12):3568-73.
1995: Frans Leenen; Bing S Huang; H Yu; B Yuan
Brain 'ouabain' mediates sympathetic hyperactivity in congestive heart failure.
Circulation research 1995;77(5):993-1000.
1995: A M Abdelrahman; E Harmsen; Frans Leenen
Dietary sodium and Na,K-ATPase activity in Dahl salt-sensitive versus salt-resistant rats.
Journal of hypertension 1995;13(5):517-22.
1995: Bing S Huang; Frans Leenen
Brain 'ouabain,' sodium, and arterial baroreflex in spontaneously hypertensive rats.
Hypertension 1995;25(4 Pt 2):814-7.
1995: Bing S Huang; Frans Leenen
Brain 'ouabain' and desensitization of arterial baroreflex by high sodium in Dahl salt-sensitive rats.
Hypertension 1995;25(3):372-6.
1995: Frans Leenen; Ross A Davies; Anne Fourney
Role of cardiac beta 2-receptors in cardiac responses to exercise in cardiac transplant patients.
Circulation 1995;91(3):685-90.
1995: Bing S Huang; Frans Leenen
Dietary Na+ and cardiopulmonary baroreflex control of renal sympathetic nerve activity in SHR.
The American journal of physiology 1995;268(1 Pt 2):H61-7.
1995: Marcel Ruzicka; Frans Leenen
Relevance of blockade of cardiac and circulatory angiotensin-converting enzyme for the prevention of volume overload-induced cardiac hypertrophy.
Circulation 1995;91(1):16-9.
1995: Frans Leenen
Cardiac trophic stimuli and the transplanted heart.
Blood pressure. Supplement 1995;2():35-8.
1994: Frans Leenen; E Harmsen; H Yu
Dietary sodium and central vs. peripheral ouabain-like activity in Dahl salt-sensitive vs. salt-resistant rats.
The American journal of physiology 1994;267(5 Pt 2):H1916-20.
1994: M White; Frans Leenen
Aging and cardiovascular responsiveness to beta-agonist in humans: role of changes in beta-receptor responses versus baroreflex activity.
Clinical pharmacology and therapeutics 1994;56(5):543-53.
1994: P H Boer; Marcel Ruzicka; W Lear; E Harmsen; J Rosenthal; Frans Leenen
Stretch-mediated activation of cardiac renin gene.
The American journal of physiology 1994;267(4 Pt 2):H1630-6.
1994: Marcel Ruzicka; F W Keeley; Frans Leenen
The renin-angiotensin system and volume overload-induced changes in cardiac collagen and elastin.
Circulation 1994;90(4):1989-96.
1994: Marcel Ruzicka; B Yuan; Frans Leenen
Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats.
Circulation 1994;90(1):484-91.
1994: Bing S Huang; X Huang; E Harmsen; Frans Leenen
Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats.
Hypertension 1994;23(6 Pt 2):1087-90.
1994: R G Schoemaker; Frans Leenen; E Harmsen
Age-related increase in sensitivity for ischemic ATP breakdown in hypertrophic hearts of SHR normalized by enalapril.
Journal of molecular and cellular cardiology 1994;26(5):649-60.
1994: Bing S Huang; Frans Leenen
Brain "ouabain" mediates the sympathoexcitatory and hypertensive effects of high sodium intake in Dahl salt-sensitive rats.
Circulation research 1994;74(4):586-95.
1994: Bing S Huang; Frans Leenen
Dietary Na and baroreflex modulation of blood pressure and RSNA in normotensive vs. spontaneously hypertensive rats.
The American journal of physiology 1994;266(2 Pt 2):H496-502.
1994: E Harmsen; R Schoemaker; J Yu; Marcel Ruzicka; Frans Leenen
Sensitivity to ischaemic ATP breakdown in different models of cardiac hypertrophy in rats.
Journal of hypertension 1994;12(1):49-57.
1994: Frans Leenen; B Yuan; james/jim Tsoporis; R M Lee
Arterial hypertrophy and pressor responsiveness during development of hypertension in spontaneously hypertensive rats.
Journal of hypertension 1994;12(1):23-32.
1993: james/jim Tsoporis; N Fields; R M Lee; Frans Leenen
Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats.
Journal of hypertension 1993;11(12):1337-45.
1993: Marcel Ruzicka; Frans Leenen
Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats.
The American journal of physiology 1993;265(5 Pt 2):H1551-6.
1993: Frans Leenen; E Harmsen; H Yu; B Yuan
Dietary sodium stimulates ouabainlike activity in adrenalectomized spontaneously hypertensive rats.
The American journal of physiology 1993;265(1 Pt 2):H421-4.
1993: L Legault; R I Ogilvie; C J Cardella; Frans Leenen
Calcium antagonists in heart transplant recipients: effects on cardiac and renal function and cyclosporine pharmacokinetics.
The Canadian journal of cardiology 1993;9(5):398-404.
1993: Frans Leenen; E Harmsen; H Yu; C Ou
Effects of dietary sodium on central and peripheral ouabain-like activity in spontaneously hypertensive rats.
The American journal of physiology 1993;264(6 Pt 2):H2051-5.
1993: Marcel Ruzicka; B Yuan; E Harmsen; Frans Leenen
The renin-angiotensin system and volume overload-induced cardiac hypertrophy in rats. Effects of angiotensin converting enzyme inhibitor versus angiotensin II receptor blocker.
Circulation 1993;87(3):921-30.
1993: Frans Leenen; Bing S Huang; E Harmsen
Role of brain ouabain-like activity in the central effects of sodium in rats.
Journal of cardiovascular pharmacology 1993;22 Suppl 2():S72-4.
1992: L Legault; P van Nguyen; D L Holliwell; Frans Leenen
Hemodynamic and plasma atrial natriuretic factor responses to cardiac volume loading in young versus older normotensive humans.
Canadian journal of physiology and pharmacology 1992;70(12):1549-54.
1992: Bing S Huang; E Harmsen; H Yu; Frans Leenen
Brain ouabain-like activity and the sympathoexcitatory and pressor effects of central sodium in rats.
Circulation research 1992;71(5):1059-66.
1992: Frans Leenen; G Klement; B Yuan
Dietary sodium restriction and pressor responsiveness to tyramine in spontaneously hypertensive rats.
Journal of hypertension 1992;10(9):929-37.
1992: Frans Leenen; B Yuan
Dietary sodium and the antihypertensive effect of nifedipine in spontaneously hypertensive rats.
American journal of hypertension 1992;5(8):515-9.
1992: B Yuan; Frans Leenen
Chronic arterial vasodilation, central hemodynamics, and cardiac hypertrophy in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1992;19(6):922-8.
1992: Bing S Huang; Frans Leenen
Dietary Na, age, and baroreflex control of heart rate and renal sympathetic nerve activity in rats.
The American journal of physiology 1992;262(5 Pt 2):H1441-8.
1992: E A Wilczynski; B Yuan; Frans Leenen
Dietary sodium restriction and the development of two-kidney, one-clip hypertension in young versus adult rats.
Canadian journal of physiology and pharmacology 1992;70(4):452-7.
1992: E Harmsen; Frans Leenen
Dietary sodium induced cardiac hypertrophy.
Canadian journal of physiology and pharmacology 1992;70(4):580-6.
1992: M A Levine; Frans Leenen
Role of vagal activity in the cardiovascular responses to phenylephrine in man.
British journal of clinical pharmacology 1992;33(3):333-6.
1992: Frans Leenen; D L Holliwell
Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.
The American journal of cardiology 1992;69(6):639-45.
1992: Bing S Huang; Frans Leenen
Brain ouabain and central effects of dietary sodium in spontaneously hypertensive rats.
Circulation research 1992;70(2):430-7.
1991: P von Nguyen; D L Holliwell; A Davis; T C Tasker; Frans Leenen
Effects of the potassium channel activator, cromakalim, on arterial and cardiac responses to norepinephrine, angiotensin II, and isoproterenol in normotensive men.
Journal of cardiovascular pharmacology 1991;18(6):797-806.
1991: B X Yuan; Frans Leenen
Dietary sodium intake and left ventricular hypertrophy in normotensive rats.
The American journal of physiology 1991;261(5 Pt 2):H1397-401.
1991: Frans Leenen; M H Strauss; Y K Chan; R J Burns
Cardiac effects of prazosin in chronic aortic insufficiency.
The Canadian journal of cardiology 1991;7(6):265-9.
1991: james/jim Tsoporis; N Fields; R M Lee; Frans Leenen
Arterial vasodilation and cardiovascular structural changes in normotensive rats.
The American journal of physiology 1991;260(6 Pt 2):H1944-52.
1991: N G Fields; B X Yuan; Frans Leenen
Sodium-induced cardiac hypertrophy. Cardiac sympathetic activity versus volume load.
Circulation research 1991;68(3):745-55.
1991: Frans Leenen; E Harmsen
Antihypertensive drugs and cardiac trophic mechanisms.
Journal of cardiovascular pharmacology 1991;17 Suppl 2():S50-7.
1991: james/jim Tsoporis; N Fields; R M Lee; Frans Leenen
Opposite effects of arterial vasodilators on cardiac vs. arterial hypertrophy and sympathetic activity in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1991;17 Suppl 2():S169-71.
1991: james/jim Tsoporis; N Fields; Frans Leenen
Contrasting effects of calcium antagonists vs. arterial vasodilators on cardiac anatomy and sympathetic activity in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 1991;17 Suppl 2():S166-8.
1990: Frans Leenen; james/jim Tsoporis
Cardiac volume load as a determinant of the response of cardiac mass to antihypertensive therapy.
European heart journal 1990;11 Suppl G():100-6.
1990: P Van Nguyen; J Cleroux; M Peterson; Frans Leenen
Beta-blockade with intrinsic sympathetic activity modifies favorably exercise-induced changes in plasma lipoproteins.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;69(2):485-9.
1990: Frans Leenen; R J Burns; M G Myers; D Frankel
Effects of nifedipine versus hydralazine on sympathetic activity and cardiac function in patients with hypertension persisting on diuretic plus beta-blocker therapy.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1990;4(2):499-504.
1990: Frans Leenen; G Klement
Dietary sodium restriction and blood pressure response to sympathetic blockade in young versus adolescent spontaneously hypertensive rats.
Canadian journal of physiology and pharmacology 1990;68(1):46-50.
1989: L F Roy; D S East; F M Browning; D Shaw; R I Ogilvie; C Cardella; Frans Leenen
Short-term effects of calcium antagonists on hemodynamics and cyclosporine pharmacokinetics in heart-transplant and kidney-transplant patients.
Clinical pharmacology and therapeutics 1989;46(6):657-67.
1989: N Fields; james/jim Tsoporis; Frans Leenen
Differential effects of the calcium antagonist, nisoldipine, versus the arterial vasodilator, minoxidil, on ventricular anatomy, intravascular volume, and sympathetic activity in rats.
Journal of cardiovascular pharmacology 1989;14(6):826-35.
1989: R A Reeves; W H Boer; L DeLeve; Frans Leenen
Beta-blockade disappearance rate predicts beta-adrenergic hypersensitivity.
Clinical pharmacology and therapeutics 1989;46(3):279-90.
1989: james/jim Tsoporis; B X Yuan; Frans Leenen
Arterial vasodilators, cardiac volume load, and cardiac hypertrophy in normotensive rats.
The American journal of physiology 1989;256(3 Pt 2):H876-80.
1989: K R Chapman; B M Galko; D L Smith; Frans Leenen
Effects of atenolol vs diltiazem on the haemodynamic effects of an inhaled beta 2-adrenoceptor agonist.
British journal of clinical pharmacology 1989;27(2):268-71.
1989: J Cleroux; P Van Nguyen; A W Taylor; Frans Leenen
Effects of beta 1- vs. beta 1 + beta 2-blockade on exercise endurance and muscle metabolism in humans.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(2):548-54.
1989: L F Roy; R I Ogilvie; P Larochelle; P Hamet; Frans Leenen
Cardiac and vascular effects of atrial natriuretic factor and sodium nitroprusside in healthy men.
Circulation 1989;79(2):383-92.
1989: Frans Leenen
Left ventricular hypertrophy in hypertensive patients.
The American journal of medicine 1989;86(1B):63-5.
1989: Frans Leenen; Corey Toal
Dietary sodium restriction and the renin-angiotensin system in young spontaneously hypertensive rats.
Journal of hypertension 1989;7(1):57-61.
1989: Frans Leenen
Functional significance of B1- versus B2-receptors for cardiac inotropic and chronotropic responses in man.
Clinical and experimental hypertension. Part A, Theory and practice 1989;11 Suppl 1():43-58.
1989: M A Levine; Frans Leenen
Role of beta 1-receptors and vagal tone in cardiac inotropic and chronotropic responses to a beta 2-agonist in humans.
Circulation 1989;79(1):107-15.
1988: Frans Leenen; G Klement
Dietary sodium restriction and blood pressure response to alpha-receptor blockade in young spontaneously hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1988;6(4):S202-4.
1988: Frans Leenen; D L Smith; WALTER UNGER
Topical minoxidil: cardiac effects in bald man.
British journal of clinical pharmacology 1988;26(4):481-5.
1988: J Cleroux; Frans Leenen
Effects of beta-blockade on muscle metabolism during prolonged exercise. A short review.
American journal of hypertension 1988;1(3 Pt 3):290S-294S.
1988: Frans Leenen; Y K Chan; D L Smith; R A Reeves
Epinephrine and left ventricular function in humans: effects of beta-1 vs nonselective beta-blockade.
Clinical pharmacology and therapeutics 1988;43(5):519-28.
1988: james/jim Tsoporis; Frans Leenen
Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats.
Hypertension 1988;11(4):376-86.
1988: Frans Leenen; D L Smith; R M Farkas; W H Boer; R A Reeves; A Marquez-Julio
Cardiovascular effects of indapamide in hypertensive patients with or without renal failure. A dose-response curve.
The American journal of medicine 1988;84(1B):76-85.
1988: P V Nguyen; D L Smith; Frans Leenen
Acute volume loading, atrial natriuretic peptide release and cardiac function in healthy men. Effects of beta-blockade.
Life sciences 1988;43(10):821-30.
1987: Frans Leenen; R A Reeves
Beta-receptor-mediated increase in venous return in humans.
Canadian journal of physiology and pharmacology 1987;65(8):1658-65.
1987: Frans Leenen; D L Smith; R M Farkas; R A Reeves; A Marquez-Julio
Vasodilators and regression of left ventricular hypertrophy. Hydralazine versus prazosin in hypertensive humans.
The American journal of medicine 1987;82(5):969-78.
1987: L F Roy; Frans Leenen
Therapeutic rounds. Nonsteroidal anti-inflammatory drugs.
Clinical therapeutics 1987;9(6):577, 690-2.
1985: E A Wilczynski; Frans Leenen
Age dependency of the effects of dietary sodium restriction on blood pressure in spontaneously hypertensive rats.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1985;3(3):S435-7.
1984: R A Reeves; W H Boer; L DeLeve; Frans Leenen
Nonselective beta-blockade enhances pressor responsiveness to epinephrine, norepinephrine, and angiotensin II in normal man.
Clinical pharmacology and therapeutics 1984;35(4):461-6.
1983: Frans Leenen; D L Smith; W H Boer; A Marquez-Julio
Diuretic and cardiovascular effects of indapamide in hypertensive subjects: a dose-response curve.
Current medical research and opinion 1983;8 Suppl 3():47-52.