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Michael Weedon

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Lavinia Paternoster; Susan M Ring; George Davey Smith; Kate Tilling; Nicholas J Timpson; Michael Weedon; David M Evans; Timothy M Frayling; Rachel M Freathy; Laura D Howe; John P Kemp; Debbie A Lawlor
Adult height variants affect birth length and growth rate in children.
Emma L Edghill; Sian Ellard; Graham A Hitman; A Khamis; Mark I McCarthy; K R Owen; A T Hattersley; Mark Walker; Michael Weedon; T M Frayling
Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
Anna Murray; Claire E Bennett; John R B Perry; Michael Weedon; Patricia A Jacobs; Danielle H Morris; Nicholas Orr; Minouk J Schoemaker; Michael Jones; Alan Ashworth; Anthony J Swerdlow
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.

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All Publications

2011: Lavinia Paternoster; Susan M Ring; George Davey Smith; Kate Tilling; Nicholas J Timpson; Michael Weedon; David M Evans; Timothy M Frayling; Rachel M Freathy; Laura D Howe; John P Kemp; Debbie A Lawlor
Adult height variants affect birth length and growth rate in children.
Human molecular genetics 2011;20(20):4069-75.
2011: Emma L Edghill; Sian Ellard; Graham A Hitman; A Khamis; Mark I McCarthy; K R Owen; A T Hattersley; Mark Walker; Michael Weedon; T M Frayling
Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 2011;28(6):681-4.
2011: Anna Murray; Claire E Bennett; John R B Perry; Michael Weedon; Patricia A Jacobs; Danielle H Morris; Nicholas Orr; Minouk J Schoemaker; Michael Jones; Alan Ashworth; Anthony J Swerdlow
Common genetic variants are significant risk factors for early menopause: results from the Breakthrough Generations Study.
Human molecular genetics 2011;20(1):186-92.
2011: B Jafar-Mohammadi; Christopher J Groves; A P Gjesing; B M Herrera; W Winckler; H M Stringham; Andrew P Morris; torsten lauritzen; Alex S F Doney; Andrew D Morris; Michael Weedon; A J Swift; J Kuusisto; M Laakso; D Altshuler; Andrew T Hattersley; F S Collins; M Boehnke; T Hansen; O Pedersen; C N A Palmer; Timothy M Frayling; Anna L Gloyn; Mark I McCarthy
A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
Diabetologia 2011;54(1):111-9.
2010: Hana Lango Allen; Stefan Johansson; Sian Ellard; Beverley Shields; Jens K Hertel; Helge Raeder; Kevin Colclough; Anders Molven; Timothy M Frayling; Pål R Njølstad; Andrew T Hattersley; Michael Weedon
Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.
Diabetes 2010;59(1):266-71.
2009: J R B Perry; Luigi Ferrucci; S Bandinelli; J Guralnik; Richard D Semba; N Rice; D Melzer; R Saxena; L J Scott; M I McCarthy; Andrew T Hattersley; E Zeggini; Michael Weedon; Timothy M Frayling
Circulating beta-carotene levels and type 2 diabetes-cause or effect?
Diabetologia 2009;52(10):2117-21.
2009: John R B Perry; Mark I McCarthy; Andrew T Hattersley; Eleftheria Zeggini; Michael Weedon; Timothy M Frayling
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
Diabetes 2009;58(6):1463-7.
2009: Rachel M Freathy; Amanda J Bennett; Susan M Ring; Beverley Shields; Christopher J Groves; Nicholas J Timpson; Michael Weedon; Eleftheria Zeggini; Cecilia M Lindgren; Hana Lango; John R B Perry; Anneli Pouta; Aimo Ruokonen; Elina Hyppönen; Chris Power; Paul Elliott; David P Strachan; Marjo-Riitta Järvelin; George Davey Smith; Mark I McCarthy; Timothy M Frayling; Andrew T Hattersley
Type 2 diabetes risk alleles are associated with reduced size at birth.
Diabetes 2009;58(6):1428-33.
2009: Nicholas J Timpson; Cecilia M Lindgren; Michael Weedon; Joshua Randall; Willem H Ouwehand; David P Strachan; N William Rayner; Mark Walker; Graham A Hitman; Alex S F Doney; Colin N A Palmer; Andrew D Morris; Andrew T Hattersley; Eleftheria Zeggini; Timothy M Frayling; Mark I McCarthy
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
Diabetes 2009;58(2):505-10.
2008: Michael Weedon; Timothy M Frayling
Reaching new heights: insights into the genetics of human stature.
Trends in genetics : TIG 2008;24(12):595-603.
2008: Sajjad Rafiq; David Melzer; Michael Weedon; H Lango; R Saxena; L J Scott; C N A Palmer; A D Morris; Mark I McCarthy; Luigi Ferrucci; Andrew T Hattersley; E Zeggini; Timothy M Frayling
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
Diabetologia 2008;51(12):2205-13.
2008: Hana Lango; Colin N A Palmer; Andrew D Morris; Eleftheria Zeggini; Andrew T Hattersley; Mark I McCarthy; Timothy M Frayling; Michael Weedon
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
Diabetes 2008;57(11):3129-35.
2008: Thomas M Barber; Amanda J Bennett; Christopher J Groves; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Anna-Liisa Hartikainen; Paul Elliott; C M Lindgren; Michael Weedon; K Koch; W H Ouwehand; Fredrik Karpe; G S Conway; J A H Wass; Marjo-Riitta Järvelin; Stephen Franks; Mark I McCarthy
Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome.
Diabetologia 2008;51(7):1153-8.
2008: Ruth J F Loos; Cecilia M Lindgren; Shengxu Li; Eleanor Wheeler; Jing Hua Zhao; Inga Prokopenko; Michael Inouye; Rachel Freathy; Antony P Attwood; Jacques Beckmann; Sonja I Berndt; Kevin B Jacobs; STEPHEN CHANOCK; Richard Hayes; Sven Bergmann; Amanda J Bennett; Sheila A Bingham; Murielle Bochud; Morris Brown; Stéphane Cauchi; John M Connell; Cyrus Cooper; George Davey Smith; Ian Day; Christian Dina; Subhajyoti De; Emmanouil T Dermitzakis; Alex S F Doney; Katherine S Elliott; Paul Elliott; David M Evans; I Sadaf Farooqi; philippe froguel; Jilur Ghori; Christopher J Groves; Rhian Gwilliam; David Hadley; Alistair Hall; Andrew T Hattersley; Johannes Hebebrand; Iris M Heid; Claudia Lamina; Christian Gieger; Thomas Illig; Thomas Meitinger; H-Erich Wichmann; blanca herrera; Anke Hinney; Sarah E Hunt; Marjo-Riitta Jarvelin; Toby Johnson; Jennifer D M Jolley; Fredrik Karpe; Andrew Keniry; Kay-Tee Khaw; Robert N Luben; Massimo Mangino; Jonathan Marchini; Wendy L McArdle; Ralph McGinnis; David Meyre; Patricia B Munroe; Andrew D Morris; Andrew R Ness; Matthew J Neville; Alexandra C Nica; Ken K Ong; Stephen O'Rahilly; Katharine R Owen; Colin N A Palmer; Konstantinos Papadakis; Simon Potter; Anneli Pouta; Lu Qi; Joshua C Randall; Nigel W Rayner; Susan M Ring; Manjinder S Sandhu; André Scherag; Matthew A Sims; Kijoung Song; Nicole Soranzo; Elizabeth K Speliotes; Holly E Syddall; Sarah A Teichmann; Nicholas J Timpson; Jonathan H Tobias; Manuela Uda; Carla I Ganz Vogel; chris wallace; Dawn M Waterworth; Michael Weedon; Cristen J Willer; Xin Yuan; Eleftheria Zeggini; Joel N Hirschhorn; David P Strachan; Willem H Ouwehand; Mark J Caulfield; Nilesh J Samani; Timothy M Frayling; Peter Vollenweider; Gerard Waeber; Vincent Mooser; Panos Deloukas; Mark I McCarthy; Nicholas J Wareham; Inês Barroso; Kevin B Jacobs; Stephen J Chanock; Richard B Hayes; Claudia Lamina; Christian Gieger; Thomas Illig; Thomas Meitinger; H-Erich Wichmann; Peter Kraft; Susan E Hankinson; David J Hunter; Frank B Hu; Helen N Lyon; Benjamin F Voight; Martin Ridderstrale; Leif Groop; Paul Scheet; serena Sanna; Goncalo Abecasis; Giuseppe Albai; Ramaiah Nagaraja; David Schlessinger; Anne U Jackson; Jaakko Tuomilehto; Francis S Collins; Michael Boehnke; Karen L Mohlke
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Nature genetics 2008;40(6):768-75.
2008: David Melzer; John R B Perry; Dena Hernandez; Anna-Maria Corsi; Kara Stevens; Ian Rafferty; Fulvio Lauretani; Anna Murray; J Raphael Gibbs; Giuseppe Paolisso; Sajjad Rafiq; Javier Simon-Sanchez; Hana Lango; Sonja Scholz; Michael Weedon; Sampath Arepalli; Neil Rice; Nicole Washecka; Alison Hurst; Angela Britton; William Henley; Joyce van de Leemput; Rongling Li; Anne B Newman; Greg Tranah; Tamara Harris; Vijay Panicker; Colin Dayan; Amanda Bennett; Mark I McCarthy; Aimo Ruokonen; Marjo-Riitta Jarvelin; Jack Guralnik; Stefania Bandinelli; Timothy M Frayling; Andrew Singleton; Luigi Ferrucci
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
PLoS genetics 2008;4(5):e1000072.
2008: Michael Weedon; Hana Lango; Cecilia M Lindgren; chris wallace; David M Evans; Massimo Mangino; Rachel Freathy; John R B Perry; Suzanne Stevens; Alistair Hall; Nilesh J Samani; Beverly Shields; Inga Prokopenko; Martin Farrall; Anna Dominiczak; Toby Johnson; Sven Bergmann; Jacques Beckmann; Peter Vollenweider; Dawn M Waterworth; Vincent Mooser; Colin N A Palmer; Andrew D Morris; Willem H Ouwehand; Jing Hua Zhao; Shengxu Li; Ruth J F Loos; Inês Barroso; Panagiotis Deloukas; Manjinder S Sandhu; Eleanor Wheeler; Nicole Soranzo; Michael Inouye; Nicholas J Wareham; Mark Caulfield; Patricia B Munroe; Andrew T Hattersley; Mark I McCarthy; Timothy M Frayling
Genome-wide association analysis identifies 20 loci that influence adult height.
Nature genetics 2008;40(5):575-83.
2008: Eleftheria Zeggini; Laura J Scott; Richa Saxena; Benjamin F Voight; Jonathan L Marchini; Tianle Hu; Paul I W de Bakker; Goncalo Abecasis; Peter Almgren; Gitte Andersen; Kristin Ardlie; Kristina Bengtsson Boström; Richard N Bergman; Lori L Bonnycastle; Knut Borch-Johnsen; Noël P Burtt; Hong Chen; Peter S Chines; Mark J Daly; Parimal Deodhar; Chia-Jen Ding; Alex S F Doney; William L Duren; Katherine S Elliott; Michael R Erdos; Timothy M Frayling; Rachel Freathy; Lauren Gianniny; Harald Grallert; Niels Grarup; Christopher J Groves; Candace Guiducci; Torben Hansen; Christian Herder; Graham A Hitman; Thomas Hughes; Bo Isomaa; Anne U Jackson; Torben Jørgensen; Augustine Kong; Kari Kubalanza; Finny G Kuruvilla; Johanna Kuusisto; Claudia Langenberg; Hana Lango; torsten lauritzen; Yun Li; Cecilia M Lindgren; Valeriya Lyssenko; Amanda F Marvelle; Christa Meisinger; Kristian Midthjell; Karen L Mohlke; Mario A Morken; Andrew D Morris; Narisu Narisu; Peter Nilsson; Katharine R Owen; Colin N A Palmer; Felicity Payne; John R B Perry; Elin Pettersen; Carl Platou; Inga Prokopenko; Lu Qi; Li Qin; Nigel W Rayner; Matthew Rees; Jeffrey J Roix; Anelli Sandbaek; Beverley Shields; Marketa Sjögren; Valgerdur Steinthorsdottir; Heather M Stringham; Amy J Swift; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Nicholas J Timpson; Tiinamaija Tuomi; Jaakko Tuomilehto; Mark Walker; Richard Watanabe; Michael Weedon; Cristen J Willer; Thomas Illig; Kristian Hveem; Frank B Hu; Markku Laakso; kari stefansson; Oluf Pedersen; Nicholas J Wareham; Inês Barroso; Andrew T Hattersley; Francis S Collins; Leif Groop; Mark I McCarthy; Michael Boehnke; David Altshuler
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nature genetics 2008;40(5):638-45.
2008: Michael Weedon; Nicholas J Timpson; Debbie A Lawlor; Anneli Pouta; Yoav Ben-Shlomo; Aimo Ruokonen; Shah Ebrahim; Beverley Shields; Eleftheria Zeggini; Michael N Weedon; Cecilia M Lindgren; Hana Lango; David Melzer; Luigi Ferrucci; Giuseppe Paolisso; Matthew J Neville; Fredrik Karpe; Colin N A Palmer; Andrew D Morris; Paul Elliott; Marjo-Riitta Jarvelin; George Davey Smith; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
Diabetes 2008;57(5):1419-26.
2008: Hana Lango; Michael Weedon
What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice?
Journal of internal medicine 2008;263(1):16-27.
2007: Laura Pascoe; Andrea Tura; Sheila K Patel; Ibrahim M Ibrahim; Ele Ferrannini; Eleftheria Zeggini; Michael Weedon; Andrea Mari; Andrew T Hattersley; Mark I McCarthy; Timothy M Frayling; Mark Walker
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Diabetes 2007;56(12):3101-4.
2007: Paul R Burton; David G Clayton; Lon R Cardon; Nick Craddock; Panos Deloukas; Audrey Duncanson; Dominic P Kwiatkowski; Mark I McCarthy; Willem H Ouwehand; Nilesh J Samani; John A Todd; Peter Donnelly; Jeffrey C Barrett; Dan Davison; Doug Easton; David M Evans; Hin-Tak Leung; Jonathan L Marchini; Andrew P Morris; Chris C A Spencer; Martin D Tobin; Antony P Attwood; James P Boorman; Barbara Cant; Ursula Everson; Judith M Hussey; Jennifer D Jolley; Alexandra S Knight; Kerstin Koch; Elizabeth Meech; Sarah Nutland; Christopher V Prowse; Helen E Stevens; Niall C Taylor; Graham R Walters; Neil M Walker; Nicholas A Watkins; Thilo Winzer; Richard W Jones; Wendy L McArdle; Susan M Ring; David P Strachan; Marcus Pembrey; Gerome Breen; David St Clair; Sian Caesar; Katharine Gordon-Smith; Lisa Jones; Christine Fraser; Elaine K Green; Detelina Grozeva; Marian L Hamshere; Peter A Holmans; Ian R Jones; George Kirov; Valentina Moskivina; Ivan Nikolov; Michael C O'Donovan; Michael J Owen; David A Collier; Amanda Elkin; Anne Farmer; Richard Williamson; Peter McGuffin; Allan H Young; Ian Nicol Ferrier; Stephen G Ball; Anthony J Balmforth; Jennifer H Barrett; D Timothy Bishop; Mark M Iles; Azhar Maqbool; Nadira Yuldasheva; Alistair S Hall; Peter S Braund; Richard J Dixon; Massimo Mangino; Suzanne Stevens; John R Thompson; Francesca Bredin; Mark Tremelling; Miles Parkes; Hazel Drummond; Charles W Lees; Elaine R Nimmo; Jack Satsangi; Sheila A Fisher; Alastair Forbes; Cathryn M Lewis; Clive M Onnie; Natalie Prescott; Jeremy Sanderson; Christopher G Matthew; Jamie Barbour; M Khalid Mohiuddin; Catherine E Todhunter; John C Mansfield; Tariq Ahmad; Fraser R Cummings; Derek P Jewell; John Webster; Morris J Brown; Mark G Lathrop; John Connell; Anna Dominiczak; Carolina A Braga Marcano; Beverley Burke; Richard Dobson; Johannie Gungadoo; Kate L Lee; Patricia B Munroe; Stephen Newhouse; Abiodun Onipinla; chris wallace; Mingzhan Xue; Mark Caulfield; Martin Farrall; Anne Barton; Ian Bruce; Hannah Donovan; Steve Eyre; Paul D Gilbert; Samantha L Hilder; Anne M Hinks; Sally L John; Catherine Potter; Alan J Silman; Deborah Symmons; Wendy Thomson; Jane Worthington; David D Dunger; Barry Widmer; Timothy M Frayling; Rachel Freathy; Hana Lango; John R B Perry; Beverley M Shields; Michael Weedon; Andrew T Hattersley; Graham A Hitman; Mark Walker; Kate S Elliott; Christopher J Groves; Cecilia M Lindgren; Nigel W Rayner; Nicolas J Timpson; Eleftheria Zeggini; Melanie Newport; Giorgio Sirugo; Emily Lyons; Fredrik Vannberg; Adrian V S Hill; Linda A Bradbury; Claire Farrar; Jennifer J Pointon; Paul Wordsworth; Matthew A Brown; Jayne A Franklyn; Joanne M Heward; Matthew J Simmonds; Stephen C L Gough; Sheila Seal; Michael R Stratton; Nazneen Rahman; Maria Ban; An Goris; Stephen J Sawcer; Alastair Compston; David Conway; Muminatou Jallow; Melanie Newport; Giorgio Sirugo; Kirk A Rockett; Suzannah J Bumpstead; Amy Chaney; Kate Downes; Mohammed J R Ghori; Rhian Gwilliam; Sarah E Hunt; Michael Inouye; Andrew Keniry; Emma King; Ralph McGinnis; Simon Potter; Rathi Ravindrarajah; Pamela Whittaker; Claire Widden; David Withers; Niall J Cardin; Dan Davison; Teresa Ferreira; Joanne Pereira-Gale; Ingeleif B Hallgrimsdo'ttir; Bryan N Howie; Zhan Su; Yik Ying Teo; Damjan Vukcevic; David Bentley; Matthew A Brown; Alastair Compston; Martin Farrall; Alistair Hall; Andrew T Hattersley; Adrian V S Hill; Miles Parkes; Marcus E Pembrey; Michael R Stratton; Sarah L Mitchell; Paul R Newby; Oliver J Brand; Jackie Carr-Smith; Simon H S Pearce; R McGinnis; A Keniry; P Deloukas; John D Reveille; Xiaodong Zhou; Anne-Marie Sims; Alison Dowling; Jacqueline Taylor; Tracy Doan; John C Davis; Laurie Savage; Michael M Ward; Thomas L Learch; Michael H Weisman; Mathew Brown
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
Nature genetics 2007;39(11):1329-37.
2007: Michael Weedon
The importance of TCF7L2.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(10):1062-6.
2007: Michael Weedon; Guillaume Lettre; Rachel Freathy; Cecilia M Lindgren; Benjamin F Voight; John R B Perry; Katherine S Elliott; Rachel Hackett; Candace Guiducci; Beverley Shields; Eleftheria Zeggini; Hana Lango; Valeriya Lyssenko; Nicholas J Timpson; Noel P Burtt; Nigel W Rayner; Richa Saxena; Kristin Ardlie; Jonathan H Tobias; Andrew R Ness; Susan M Ring; Colin N A Palmer; Andrew D Morris; Leena Peltonen; Veikko Salomaa; George Davey Smith; Leif C Groop; Andrew T Hattersley; Mark I McCarthy; Joel N Hirschhorn; Timothy M Frayling
A common variant of HMGA2 is associated with adult and childhood height in the general population.
Nature genetics 2007;39(10):1245-50.
2007: N M G De Silva; A Steele; Beverley Shields; Beatrice Knight; K Parnell; Michael Weedon; Andrew T Hattersley; Timothy M Frayling
The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(10):1067-72.
2007: Sajjad Rafiq; Timothy M Frayling; Anna Murray; Alison Hurst; K Stevens; Michael Weedon; William Henley; Luigi Ferrucci; Stefania Bandinelli; Anna-Maria Corsi; Jack M Guralnik; David Melzer
A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.
Genes and immunity 2007;8(7):552-9.
2007: Manjinder S Sandhu; Michael Weedon; Katherine A Fawcett; Jon Wasson; Sally L Debenham; Allan Daly; Hana Lango; Timothy M Frayling; Rosalind J Neumann; Richard Sherva; Ilana Blech; Paul D P Pharoah; Colin N A Palmer; Charlotte Kimber; Roger Tavendale; Andrew D Morris; Mark I McCarthy; Mark Walker; Graham A Hitman; Benjamin Glaser; M Alan Permutt; Andrew T Hattersley; Nicholas J Wareham; Inês Barroso
Common variants in WFS1 confer risk of type 2 diabetes.
Nature genetics 2007;39(8):951-3.
2007: Michael Weedon; Michael N Weedon; Amanda Bennett; Elina Hypponen; Caroline L Relton; Beatrice Knight; Beverley Shields; Kirstie S Parnell; Christopher J Groves; Susan M Ring; Marcus E Pembrey; Yoav Ben-Shlomo; David P Strachan; Chris Power; Marjo-Riitta Jarvelin; Mark I McCarthy; George Davey Smith; Andrew T Hattersley; Timothy M Frayling
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
American journal of human genetics 2007;80(6):1150-61.
2007: Eleftheria Zeggini; Michael N Weedon; Cecilia M Lindgren; Timothy M Frayling; Katherine S Elliott; Hana Lango; Nicholas J Timpson; John R B Perry; Nigel W Rayner; Michael Weedon; Jeffrey C Barrett; Beverley Shields; Andrew P Morris; Sian Ellard; Christopher J Groves; Lorna W Harries; Jonathan Marchini; Katharine R Owen; Beatrice Knight; Lon R Cardon; Mark Walker; Graham A Hitman; Andrew D Morris; Alex S F Doney; Mark I McCarthy; Andrew T Hattersley
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Science (New York, N.Y.) 2007;316(5829):1336-41.
2007: Sajjad Rafiq; K Stevens; Alison Hurst; Anna Murray; William Henley; Michael Weedon; Stefania Bandinelli; Anna-Maria Corsi; Jack M Guralnik; Luigi Ferrucci; David Melzer; Timothy M Frayling
Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels.
Genes and immunity 2007;8(4):344-51.
2007: Thomas M Barber; Amanda J Bennett; Anna L Gloyn; Christopher J Groves; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Saara Taponen; Michael Weedon; Anna-Liisa Hartikainen; J A H Wass; Marjo-Riitta Järvelin; Eleftheria Zeggini; Stephen Franks; Mark I McCarthy
Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.
European journal of human genetics : EJHG 2007;15(6):679-84.
2007: Timothy M Frayling; Nicholas J Timpson; Michael Weedon; Eleftheria Zeggini; Rachel Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
Science (New York, N.Y.) 2007;316(5826):889-94.
2007: Michael Weedon; Timothy M Frayling
Insights on pathogenesis of type 2 diabetes from MODY genetics.
Current diabetes reports 2007;7(2):131-8.
2007: Wendy Winckler; Michael Weedon; Robert R Graham; Steven A McCarroll; Shaun Purcell; Peter Almgren; Tiinamaija Tuomi; Daniel Gaudet; Kristina Bengtsson Boström; Mark Walker; Graham A Hitman; Andrew T Hattersley; Mark I McCarthy; Kristin G Ardlie; Joel N Hirschhorn; Mark J Daly; Timothy M Frayling; Leif Groop; David Altshuler
Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
Diabetes 2007;56(3):685-93.
2007: Timothy M Frayling; Sajjad Rafiq; Anna Murray; Alison Hurst; Michael Weedon; William Henley; Stefania Bandinelli; Anna-Maria Corsi; Luigi Ferrucci; Jack M Guralnik; Robert B Wallace; David Melzer
An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(1):73-8.
2006: Michael Weedon; Vanessa J Clark; Yudong Qian; Yoav Ben-Shlomo; Nicholas Timpson; Shah Ebrahim; Debbie A Lawlor; Marcus E Pembrey; Susan M Ring; Terence J Wilkin; Linda D Voss; Alison N Jeffery; Brad S Metcalf; Luigi Ferrucci; Anna-Maria Corsi; Anna Murray; David Melzer; Beatrice Knight; Beverley Shields; George Davey Smith; Andrew T Hattersley; Anna Di Rienzo; Timothy M Frayling
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.
American journal of human genetics 2006;79(6):991-1001.
2006: Michael Weedon; Beverley Shields; Graham A Hitman; Mark Walker; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
Diabetes 2006;55(11):3175-9.
2006: Michael Weedon; Mark I McCarthy; Graham A Hitman; Mark Walker; Christopher J Groves; Eleftheria Zeggini; Nigel W Rayner; Beverley Shields; Katharine R Owen; Andrew T Hattersley; Timothy M Frayling
Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
PLoS medicine 2006;3(10):e374.
2006: Christopher J Groves; Eleftheria Zeggini; Jayne A L Minton; Timothy M Frayling; Michael Weedon; Nigel W Rayner; Graham A Hitman; Mark Walker; Steven Wiltshire; Andrew T Hattersley; Mark I McCarthy
Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
Diabetes 2006;55(9):2640-4.
2006: Takafumi Tsuchiya; Peter E H Schwarz; Laura Del Bosque-Plata; M Geoffrey Hayes; Christian Dina; philippe froguel; G Wayne Towers; Sabine Fischer; Theodora Temelkova-Kurktschiev; Hannes Rietzsch; Juergen Graessler; Josef Vcelák; Daniela Palyzová; Thomas Selisko; Bela Bendlová; Jan Schulze; Ulrich Julius; Markolf Hanefeld; Michael Weedon; Julie C Evans; Timothy M Frayling; Andrew T Hattersley; Marju Orho-Melander; Leif Groop; Maciej T Malecki; Torben Hansen; Oluf Pedersen; Tasha E Fingerlin; Michael Boehnke; Craig L Hanis; Nancy J Cox; Graeme I Bell
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses.
Molecular genetics and metabolism 2006;89(1-2):174-84.
2006: Anna L Gloyn; Deborah J G Mackay; Michael Weedon; Mark I McCarthy; Mark Walker; Graham A Hitman; Bridget A Knight; Katharine R Owen; Andrew T Hattersley; Timothy M Frayling
Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
Diabetes 2006;55(8):2272-6.
2006: S Patel; Jayne A L Minton; Michael Weedon; Timothy M Frayling; Christopher Ricketts; Graham A Hitman; Mark I McCarthy; Andrew T Hattersley; Mark Walker; Timothy G Barrett
Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
Diabetologia 2006;49(6):1209-13.
2006: Michael Weedon; Kathryn F Lonnen; Anna M Steele; Jayne A L Minton; Timothy M Frayling; Andrew T Hattersley; Kenneth M MacLeod
The impact of the angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycemia in Type 2 diabetes.
The review of diabetic studies : RDS 2006;3(2):76-81.
2006: David Melzer; Anna Murray; Alison Hurst; Michael Weedon; Stefania Bandinelli; Anna-Maria Corsi; Luigi Ferrucci; Guiseppe Paolisso; Jack M Guralnik; Timothy M Frayling
Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.
BMC medicine 2006;4():34.
2006: Michael Weedon; Simon M S Mitchell; Beatrice Knight; Beverley Shields; Michael N Weedon; Andrew T Hattersley; Timothy M Frayling
A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population.
Journal of negative results in biomedicine 2006;5():18.
2006: Giriraj R Chandak; Kirsten J Ward; Chittaranjan S Yajnik; Anand N Pandit; Ashish Bavdekar; Charu V Joglekar; Caroline H D Fall; P Mohankrishna; Terence J Wilkin; Brad S Metcalf; Michael Weedon; Timothy M Frayling; Andrew T Hattersley
Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans.
BMC medical genetics 2006;7():76.
2006: Michael Weedon; Michael N Weedon; David Melzer; Beverley Shields; Graham A Hitman; Mark Walker; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
BMC medical genetics 2006;7():51.
2006: Michael Weedon; Michael N Weedon; Beverley Shields; Graham A Hitman; Mark Walker; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
JOP : Journal of the pancreas 2006;7(3):295-302.
2005: Michael Weedon; Katharine R Owen; Beverley Shields; Graham A Hitman; Mark Walker; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Diabetes 2005;54(8):2487-91.
2005: Michael Weedon; Timothy M Frayling; Beverley Shields; Beatrice Knight; Tina Turner; Brad S Metcalf; Linda D Voss; Terence J Wilkin; Anne McCarthy; Yoav Ben-Shlomo; George Davey Smith; Susan M Ring; Richard Jones; Jean Golding; Liisa Byberg; Vera Mann; Tomas Axelsson; Ann-Christine Syvänen; David Leon; Andrew T Hattersley
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Diabetes 2005;54(2):576-81.
2004: Michael Weedon; Katharine R Owen; Beverley Shields; Graham A Hitman; Mark Walker; Mark I McCarthy; Latisha Love-Gregory; M Alan Permutt; Andrew T Hattersley; Timothy M Frayling
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Diabetes 2004;53(11):3002-6.
2004: Michael Weedon; Andrew T Hattersley; Timothy M Frayling
Tall stories: the fundamental difficulties of genetic association studies.
Clinical endocrinology 2004;60(1):145-6.
2003: Michael Weedon; P E H Schwarz; Yukio Horikawa; Naoko Iwasaki; Thomas Illig; Rolf Holle; Wolfgang Rathmann; Thomas Selisko; Jan Schulze; Katharine R Owen; Julie Evans; Laura Del Bosque-Plata; Graham A Hitman; Mark Walker; Jonathan C Levy; Mike Sampson; Graeme I Bell; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.
American journal of human genetics 2003;73(5):1208-12.
2003: Michael Weedon; Martina Turner; Beatrice Knight; Penny Clark; Andrew T Hattersley; Timothy M Frayling
Variants in the aromatase gene and on the Y-chromosome are not associated with adult height or insulin resistance in a UK population.
Clinical endocrinology 2003;59(2):175-9.
2003: Michael Weedon; Anna L Gloyn; Timothy M Frayling; A T Hattersley; G Davey Smith; Y Ben-Shlomo
Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.
Diabetologia 2003;46(7):1021-3.
2003: Simon M S Mitchell; Michael Weedon; Katharine R Owen; Beverley Shields; Beverley Wilkins-Wall; Mark Walker; Mark I McCarthy; Timothy M Frayling; Andrew T Hattersley
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
Diabetes 2003;52(5):1276-9.
2003: Anna L Gloyn; Michael Weedon; Katharine R Owen; Martina J Turner; Bridget A Knight; Graham A Hitman; Mark Walker; Jonathan C Levy; Mike Sampson; Stephanie Halford; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Diabetes 2003;52(2):568-72.
2002: Willy A Solis; Nicole L Childs; Michael Weedon; Lei He; Daniel W Nebert; Timothy P Dalton
Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity.
Toxicology and applied pharmacology 2002;178(2):93-101.