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Frédéric Simonin

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Chemicals & Drugs

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Olivier Bornert; Marie-Pierre Candusso; Karen L Martinez; Thor C Møller; Julien Boeuf; Renaud Wagner; Frédéric Simonin
Identification of a novel protein-protein interaction motif mediating interaction of GPCR-associated sorting proteins with G protein-coupled receptors.
Ronan Gealageas; Jean-Paul Humbert; Emilie Laboureyras; Catherine Mollereau; Martine Schmitt; Séverine Schneider; Frédéric Simonin; Guy Simonnet; Isabelle Bertin; Jean-Jacques Bourguignon; Christophe Dugave; Frederic Bihel
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.
K Elhabazi; Rafael Maldonado; H Meziane; Catherine Mollereau; Lionel Moulédous; B Petit-demoulière; Martine Schmitt; Frederic Bihel; F Bockel; Jean-Jacques Bourguignon; J M Trigo; Jean-Marie Zajac; Frédéric Simonin
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.

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All Publications

2013: Olivier Bornert; Marie-Pierre Candusso; Karen L Martinez; Thor C Møller; Julien Boeuf; Renaud Wagner; Frédéric Simonin
Identification of a novel protein-protein interaction motif mediating interaction of GPCR-associated sorting proteins with G protein-coupled receptors.
PloS one 2013;8(2):e56336.
2012: Ronan Gealageas; Jean-Paul Humbert; Emilie Laboureyras; Catherine Mollereau; Martine Schmitt; Séverine Schneider; Frédéric Simonin; Guy Simonnet; Isabelle Bertin; Jean-Jacques Bourguignon; Christophe Dugave; Frederic Bihel
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.
Bioorganic & medicinal chemistry letters 2012;22(24):7471-4.
2012: K Elhabazi; Rafael Maldonado; H Meziane; Catherine Mollereau; Lionel Moulédous; B Petit-demoulière; Martine Schmitt; Frederic Bihel; F Bockel; Jean-Jacques Bourguignon; J M Trigo; Jean-Marie Zajac; Frédéric Simonin
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
British journal of pharmacology 2012;165(2):424-35.
2011: Chantal Mathis; J-B Bott; M-P Candusso; Frédéric Simonin; Jean-Christophe Cassel
Impaired striatum-dependent behavior in GASP-1-knock-out mice.
Genes, brain, and behavior 2011;10(3):299-308.
2010: Alaa Abu-Helo; Frédéric Simonin
Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs).
Pharmacology & therapeutics 2010;126(3):244-50.
2009: Julien Boeuf; José Manuel Trigo; Pierre-Henri Moreau; Lucas Lecourtier; Elise Vogel; Jean-Christophe Cassel; Chantal Mathis; Paul Klosen; Rafael Maldonado; Frédéric Simonin
Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice.
The European journal of neuroscience 2009;30(5):860-8.
2007: Jack H Jhamandas; Frédéric Simonin; Jean-Jacques Bourguignon; Kim H Harris
Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(5):R1872-80.
2006: Jean-Jacques Bourguignon; Guy Simonnet; Frédéric Simonin
[RF9, a powerful and selective antagonist of the neuropeptide FF receptors, prevents the development of the tolerance to opioids].
Médecine sciences : M/S 2006;22(6-7):579-80.
2006: Frédéric Simonin; Martine Schmitt; Jean-Paul Laulin; Emilie Laboureyras; Jack H Jhamandas; David MacTavish; Audrey Matifas; Catherine Mollereau; Patrick Laurent; Marc Parmentier; Jerome Becker; Jean-Jacques Bourguignon; Guy Simonnet
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(2):466-71.
2005: Krisztina M Kovacs; Istvan Szakall; Danielle O'Brien; Ray Wang; K Yaragudri Vinod; Mariko Saito; Frédéric Simonin; Jerome Becker; Csaba Vadasz
Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice.
Alcoholism, clinical and experimental research 2005;29(5):730-8.
2004: Frédéric Simonin; Pascale Karcher; Julien J-M Boeuf; Audrey Matifas; Jerome Becker
Identification of a novel family of G protein-coupled receptor associated sorting proteins.
Journal of neurochemistry 2004;89(3):766-75.
2004: Sylvia Van Cauwenberghe; Frédéric Simonin; Jérôme Cluzeau; Jerome Becker; William D Lubell; Dirk Tourwé
Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.
Journal of medicinal chemistry 2004;47(7):1864-7.
2004: Claire Gaveriaux-Ruff; Frédéric Simonin; Dominique Filliol; Bruno Kieffer
Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice.
Journal of neuroimmunology 2004;147(1-2):121-2.
2003: Laure Jamot; H W D Matthes; Frédéric Simonin; Jerome Becker; John C Roder
Differential involvement of the mu and kappa opioid receptors in spatial learning.
Genes, brain, and behavior 2003;2(2):80-92.
2003: Claire Gavériaux-Ruff; Frédéric Simonin; Dominique Filliol; Jerome Becker
Enhanced humoral response in kappa-opioid receptor knockout mice.
Journal of neuroimmunology 2003;134(1-2):72-81.
2002: Liliane Halab; Jerome Becker; Zsuzsanna Darula; Dirk Tourwé; Brigitte L Kieffer; Frédéric Simonin; William D Lubell
Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.
Journal of medicinal chemistry 2002;45(24):5353-7.
2002: Frédéric Simonin; Jerome Becker
Two faces for an opioid peptide--and more receptors for pain research.
Nature neuroscience 2002;5(3):185-6.
2002: Sandy Ghozland; H W D Matthes; Frédéric Simonin; Dominique Filliol; Jerome Becker; Rafael Maldonado
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):1146-54.
2001: Claire Gavériaux-Ruff; Dominique Filliol; Frédéric Simonin; H W D Matthes; Jerome Becker
Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.
The Journal of pharmacology and experimental therapeutics 2001;298(3):1193-8.
2001: Frédéric Simonin; Susan Slowe; Jerome Becker; H W D Matthes; Dominique Filliol; JOHANNA CHLUBA; Ian Kitchen; Brigitte L Kieffer
Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice.
European journal of pharmacology 2001;414(2-3):189-95.
2001: Susan Slowe; Siân Clarke; I Lena; Robin J Goody; Roberta Lattanzi; Lucia Negri; Frédéric Simonin; H W D Matthes; Dominique Filliol; Jerome Becker; Ian Kitchen
Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice.
Neuroscience 2001;106(3):469-80.
2000: Raffaella Bigoni; Anna Rizzi; Daniela Rizzi; Jerome Becker; Brigitte L Kieffer; Frédéric Simonin; Domenico Regoli; Girolamo Calo
In vitro pharmacological profile of peptide III-BTD: a novel ligand for nociceptin/orphanin FQ and opioid receptors.
Life sciences 2000;68(2):233-9.
2000: Dominique Filliol; Sandy Ghozland; JOHANNA CHLUBA; M Martin; H W D Matthes; Frédéric Simonin; Katia Befort; Claire Gavériaux-Ruff; Andrée Dierich; Marianne LeMeur; O Valverde; Rafael Maldonado; Jerome Becker
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.
Nature genetics 2000;25(2):195-200.
1999: Jerome Becker; A Wallace; A Garzon; Paolo Ingallinella; Elisabetta Bianchi; Riccardo Cortese; Frédéric Simonin; Brigitte L Kieffer; Antonello Pessi
Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library.
The Journal of biological chemistry 1999;274(39):27513-22.
1999: Susan Slowe; Frédéric Simonin; Bruno Kieffer; Ian Kitchen
Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.
Brain research 1999;818(2):335-45.
1998: Shaobo Zhang; Y Tong; M Tian; Robert N DeHaven; L Cortesburgos; Erik Mansson; Frédéric Simonin; Bruno Kieffer; Lei Yu
Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family.
The Journal of pharmacology and experimental therapeutics 1998;286(1):136-41.
1998: Frédéric Simonin; O Valverde; C Smadja; Susan Slowe; Ian Kitchen; Andrée Dierich; Marianne Le Meur; Bernard P Roques; Rafael Maldonado; Jerome Becker
Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.
The EMBO journal 1998;17(4):886-97.
1997: Claire Gavériaux-Ruff; Jean Peluso; Katia Befort; Frédéric Simonin; C Zilliox; Jerome Becker
Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the delta- and kappa-opioid receptors.
Brain research. Molecular brain research 1997;48(2):298-304.
1997: Dominique Massotte; L Baroche; Frédéric Simonin; L Yu; Bruno Kieffer; Franc Pattus
Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells.
The Journal of biological chemistry 1997;272(32):19987-92.
1996: H W D Matthes; Rafael Maldonado; Frédéric Simonin; O Valverde; Susan Slowe; I Kitchen; Katia Befort; Andrée Dierich; Marianne Le Meur; Pascal Dollé; Eleni T Tzavara; Jacques Hanoune; Bernard P Roques; B L Kieffer
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.
Nature 1996;383(6603):819-23.
1995: C Gavériaux; Jean Peluso; Frédéric Simonin; J Laforet; B Kieffer
Identification of kappa- and delta-opioid receptor transcripts in immune cells.
FEBS letters 1995;369(2-3):272-6.
1995: Frédéric Simonin; Claire Gavériaux-Ruff; Katia Befort; H W D Matthes; Béatrice Lannes; G Micheletti; M G Mattéi; G Charron; B Bloch; B Kieffer
kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):7006-10.
1994: Frédéric Simonin; Katia Befort; Claire Gavériaux-Ruff; H W D Matthes; V Nappey; Béatrice Lannes; G Micheletti; B Kieffer
The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain.
Molecular pharmacology 1994;46(6):1015-21.
1993: Frédéric Simonin; L Höfferer; P L Panzeter; S Muller; Gilbert de Murcia; Felix R Althaus
The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization.
The Journal of biological chemistry 1993;268(18):13454-61.
1993: Frédéric Simonin; Olivier Poch; M Delarue; Gilbert de Murcia
Identification of potential active-site residues in the human poly(ADP-ribose) polymerase.
The Journal of biological chemistry 1993;268(12):8529-35.
1992: H Giner; Frédéric Simonin; Gilbert de Murcia; Josiane Ménissier-de Murcia
Overproduction and large-scale purification of the human poly(ADP-ribose) polymerase using a baculovirus expression system.
Gene 1992;114(2):279-83.
1991: Frédéric Simonin; J P Briand; S Muller; Gilbert de Murcia
Detection of poly(ADP ribose) polymerase in crude extracts by activity-blot.
Analytical biochemistry 1991;195(2):226-31.
1990: Frédéric Simonin; Josiane Ménissier-de Murcia; Olivier Poch; S Muller; Gérard Gradwohl; M Molinete; C Penning; G Keith; Gilbert de Murcia
Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.
The Journal of biological chemistry 1990;265(31):19249-56.
1990: J Thibodeau; Frédéric Simonin; M Favazza; Gérard Gradwohl; G Poirier; Gilbert de Murcia
Expression in E. coli of the catalytic domain of rat poly(ADP-ribose)polymerase.
FEBS letters 1990;264(1):81-3.
1990: Gérard Gradwohl; Josiane Ménissier-de Murcia; M Molinete; Frédéric Simonin; Marcel Koken; Jan H J Hoeijmakers; Gilbert de Murcia
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):2990-4.
1989: Josiane Ménissier-de Murcia; M Molinete; Gérard Gradwohl; Frédéric Simonin; Gilbert de Murcia
Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.
Journal of molecular biology 1989;210(1):229-33.
1989: Gérard Gradwohl; Josiane Ménissier-de Murcia; M Molinete; Frédéric Simonin; Gilbert de Murcia
Expression of functional zinc finger domain of human poly(ADP-ribose)polymerase in E. coli.
Nucleic acids research 1989;17(17):7112.
1989: A Mazen; Josiane Menissier-de Murcia; M Molinete; Frédéric Simonin; Gérard Gradwohl; G Poirier; Gilbert de Murcia
Poly(ADP-ribose)polymerase: a novel finger protein.
Nucleic acids research 1989;17(12):4689-98.