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Angelos Gritzapis

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Ioannis F Voutsas; Katerina Fotopoulou; Angelos D Gritzapis; Nikiforos Kapranos; Louisa G Mahaira; Michail Papamichail; Sonia Perez; John G Reclos; Constantin N Baxevanis
Gamma-irradiation induces HER-2/neu overexpression in breast cancer cell lines and sensitivity to treatment with trastuzumab.
Stéphanie A-S Laversin; Geng Li; Stéphanie E B McArdle; Amanda K Miles; Ioannis Missitzis; Vinaya M Phatak; Des G Powe; Graham R Ball; Ian O Ellis; Angelos D Gritzapis; David C Hughes; Robert C Rees
Identification of novel breast cancer-associated transcripts by UniGene database mining and gene expression analysis in normal and malignant cells.
Ioannis D Xynos; Ioannis F Voutsas; Sousana Amptoulach; Angelos D Gritzapis; Maria L Karadima; Christos Kosmas; Elias Skopelitis; Nikolas Tsavaris
Chemotherapy ± cetuximab modulates peripheral immune responses in metastatic colorectal cancer.

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All Publications

2013: Ioannis F Voutsas; Katerina Fotopoulou; Angelos D Gritzapis; Nikiforos Kapranos; Louisa G Mahaira; Michail Papamichail; Sonia Perez; John G Reclos; Constantin N Baxevanis
Gamma-irradiation induces HER-2/neu overexpression in breast cancer cell lines and sensitivity to treatment with trastuzumab.
International journal of radiation biology 2013;89(5):319-25.
2013: Stéphanie A-S Laversin; Geng Li; Stéphanie E B McArdle; Amanda K Miles; Ioannis Missitzis; Vinaya M Phatak; Des G Powe; Graham R Ball; Ian O Ellis; Angelos D Gritzapis; David C Hughes; Robert C Rees
Identification of novel breast cancer-associated transcripts by UniGene database mining and gene expression analysis in normal and malignant cells.
Genes, chromosomes & cancer 2013;52(3):316-29.
2013: Ioannis D Xynos; Ioannis F Voutsas; Sousana Amptoulach; Angelos D Gritzapis; Maria L Karadima; Christos Kosmas; Elias Skopelitis; Nikolas Tsavaris
Chemotherapy ± cetuximab modulates peripheral immune responses in metastatic colorectal cancer.
Oncology 2013;84(5):273-83.
2012: Angelos D Gritzapis; Ioannis F Voutsas; Constantin N Baxevanis
Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice.
Cancer immunology, immunotherapy : CII 2012;61(3):397-407.
2010: Sonia Perez; Eric von Hofe; Nikoletta L Kallinteris; Angelos D Gritzapis; George E Peoples; Michael Papamichail; Constantin N Baxevanis
A new era in anticancer peptide vaccines.
Cancer 2010;116(9):2071-80.
2010: Eftychia Lekka; Angelos D Gritzapis; Sonia Perez; Nicolas Tsavaris; Ioannis Missitzis; Avgi Mamalaki; Michael Papamichail; Constantin N Baxevanis
Identification and characterization of a HER-2/neu epitope as a potential target for cancer immunotherapy.
Cancer immunology, immunotherapy : CII 2010;59(5):715-27.
2010: Angelos D Gritzapis; Ioannis F Voutsas; Eftychia Lekka; Michael Papamichail; Constantin N Baxevanis
Peptide vaccination breaks tolerance to HER-2/neu by generating vaccine-specific FasL(+) CD4(+) T cells: first evidence for intratumor apoptotic regulatory T cells.
Cancer research 2010;70(7):2686-96.
2010: Constantin N Baxevanis; Ioannis F Voutsas; Angelos D Gritzapis; Sonia A Perez; Michael Papamichail
HER-2/neu as a target for cancer vaccines.
Immunotherapy 2010;2(2):213-26.
2009: Angelos D Gritzapis; Arthur Fridman; Sonia Perez; Nicola La Monica; Michael Papamichail; Luigi Aurisicchio; Constantin N Baxevanis
HER-2/neu (657-665) represents an immunogenic epitope of HER-2/neu oncoprotein with potent antitumor properties.
Vaccine 2009;28(1):162-70.
2008: Angelos D Gritzapis; Ioannis F Voutsas; Eftychia Lekka; Nikolaos Tsavaris; Ioannis Missitzis; Panagiota Sotiropoulou; Sonia Perez; Michael Papamichail; Constantin N Baxevanis
Identification of a novel immunogenic HLA-A*0201-binding epitope of HER-2/neu with potent antitumor properties.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):146-54.
2007: Ioannis F Voutsas; Angelos D Gritzapis; Louisa G Mahaira; Maria Salagianni; Eric von Hofe; Nikoletta L Kallinteris; Constantin N Baxevanis
Induction of potent CD4+ T cell-mediated antitumor responses by a helper HER-2/neu peptide linked to the Ii-Key moiety of the invariant chain.
International journal of cancer. Journal international du cancer 2007;121(9):2031-41.
2007: Ioannis F Voutsas; Angelos D Gritzapis; Michael N Alexis; Efrosini S Katsanou; Sonia Perez; Constantin N Baxevanis; Michael Papamichail
A novel quantitative flow cytometric method for measuring glucocorticoid receptor (GR) in cell lines: correlation with the biochemical determination of GR.
Journal of immunological methods 2007;324(1-2):110-9.
2007: Nectaria N Sotiriadou; Nikoletta L Kallinteris; Angelos D Gritzapis; Ioannis F Voutsas; Michael Papamichail; Eric von Hofe; Robert E Humphreys; Theodoros Pavlis; Sonia Perez; Constantin N Baxevanis
Ii-Key/HER-2/neu(776-790) hybrid peptides induce more effective immunological responses over the native peptide in lymphocyte cultures from patients with HER-2/neu+ tumors.
Cancer immunology, immunotherapy : CII 2007;56(5):601-13.
2006: Angelos D Gritzapis; Louisa G Mahaira; Sonia Perez; Nike T Cacoullos; Michael Papamichail; Constantin N Baxevanis
Vaccination with human HER-2/neu (435-443) CTL peptide induces effective antitumor immunity against HER-2/neu-expressing tumor cells in vivo.
Cancer research 2006;66(10):5452-60.
2006: Sonia Perez; Louisa G Mahaira; Panagiota A Sotiropoulou; Angelos D Gritzapis; Eleni G Iliopoulou; Dimitrios K Niarchos; Nike T Cacoullos; Yannis G Kavalakis; Aris I Antsaklis; Nectaria N Sotiriadou; Constantin N Baxevanis; Michael Papamichail
Effect of IL-21 on NK cells derived from different umbilical cord blood populations.
International immunology 2006;18(1):49-58.
2006: Panagiota A Sotiropoulou; Sonia Perez; Angelos D Gritzapis; Constantin N Baxevanis; Michael Papamichail
Interactions between human mesenchymal stem cells and natural killer cells.
Stem cells (Dayton, Ohio) 2006;24(1):74-85.
2006: Constantin N Baxevanis; Nectaria N Sotiriadou; Angelos D Gritzapis; Panagiota A Sotiropoulou; Sonia Perez; Nike T Cacoullos; Michael Papamichail
Immunogenic HER-2/neu peptides as tumor vaccines.
Cancer immunology, immunotherapy : CII 2006;55(1):85-95.
2005: Sonia Perez; Louisa G Mahaira; Fillio J Demirtzoglou; Panagiota A Sotiropoulou; Panayotis Ioannidis; Eleni G Iliopoulou; Angelos D Gritzapis; Nectaria N Sotiriadou; Constantin N Baxevanis; Michael Papamichail
A potential role for hydrocortisone in the positive regulation of IL-15-activated NK-cell proliferation and survival.
Blood 2005;106(1):158-66.
2005: Panayotis Ioannidis; Louisa G Mahaira; Sonia Perez; Angelos D Gritzapis; Panagiota A Sotiropoulou; Giannis J Kavalakis; Aris I Antsaklis; Constantin N Baxevanis; Michael Papamichail
CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells.
The Journal of biological chemistry 2005;280(20):20086-93.
2005: Nectaria N Sotiriadou; Sonia Perez; Angelos D Gritzapis; Louisa G Mahaira; Maria Salagianni; Constantin N Baxevanis; Michael Papamichail
Beneficial effect of short-term exposure of human NK cells to IL15/IL12 and IL15/IL18 on cell apoptosis and function.
Cellular immunology 2005;234(1):67-75.
2005: Angelos D Gritzapis; Sonia Perez; Constantin N Baxevanis; Michael Papamichail
Pooled peptides from HER-2/neu-overexpressing primary ovarian tumours induce CTL with potent antitumour responses in vitro and in vivo.
British journal of cancer 2005;92(1):72-9.
2004: Angelos D Gritzapis; Nectaria N Sotiriadou; Michael Papamichail; Constantin N Baxevanis
Generation of human tumor-specific CTLs in HLA-A2.1-transgenic mice using unfractionated peptides from eluates of human primary breast and ovarian tumors.
Cancer immunology, immunotherapy : CII 2004;53(11):1027-40.
2004: Michael Papamichail; Sonia Perez; Angelos D Gritzapis; Constantin N Baxevanis
Natural killer lymphocytes: biology, development, and function.
Cancer immunology, immunotherapy : CII 2004;53(3):176-86.
2004: Costas Phenekos; Andromachi Vryonidou; Angelos D Gritzapis; Constantin N Baxevanis; Margarita Goula; Michael Papamichail
Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto's thyroiditis (Th1) and Graves' disease (Th2).
Neuroimmunomodulation 2004;11(4):209-13.
2003: Constantin N Baxevanis; Angelos D Gritzapis; Michael Papamichail
In vivo antitumor activity of NKT cells activated by the combination of IL-12 and IL-18.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2953-9.
2003: Avgi Mamalaki; Angelos D Gritzapis; Androniki Kretsovali; Maria M Belimezi; Joseph Papamatheakis; Sonia Perez; Michael Papamichail; Constantin N Baxevanis
In vitro and in vivo antitumor activity of a mouse CTL hybridoma expressing chimeric receptors bearing the single chain Fv from HER-2/neu- specific antibody and the gamma-chain from Fc(epsilon) RI.
Cancer immunology, immunotherapy : CII 2003;52(8):513-22.
2003: Angelos D Gritzapis; Constantin N Baxevanis; Ioannis Missitzis; Efrosini S Katsanou; Michael N Alexis; Julia Yotis; Michael Papamichail
Quantitative fluorescence cytometric measurement of estrogen and progesterone receptors: correlation with the hormone binding assay.
Breast cancer research and treatment 2003;80(1):1-13.
2003: Sonia Perez; Panagiota A Sotiropoulou; Dimitra G Gkika; Louisa G Mahaira; Dimitrios K Niarchos; Angelos D Gritzapis; Yiannis G Kavalakis; Aris I Antsaklis; Constantin N Baxevanis; Michael Papamichail
A novel myeloid-like NK cell progenitor in human umbilical cord blood.
Blood 2003;101(9):3444-50.
2003: Angelos D Gritzapis; Avgi Mamalaki; Androniki Kretsovali; Joseph Papamatheakis; Maria M Belimezi; Sonia Perez; Constantin N Baxevanis; Michael Papamichail
Redirecting mouse T hybridoma against human breast and ovarian carcinomas: in vivo activity against HER-2/neu expressing cancer cells.
British journal of cancer 2003;88(8):1292-300.
2002: Loris Zamai; Barbara Canonico; Angelos D Gritzapis; Francesca Luchetti; C Felici; M Della Felice; L Margomenou; M Papamichail; J W Gratama; Stefano Papa
Intracellular detection of Bcl-2 and p53 proteins by flow cytometry: comparison of monoclonal antibodies and sample preparation protocols.
Journal of biological regulators and homeostatic agents 2002;16(4):289-302.
2002: Angelos D Gritzapis; Dimitris Dimitroulopoulos; Emmanuel Paraskevas; Constantin N Baxevanis; Michael Papamichail
Large-scale expansion of CD3(+)CD56(+) lymphocytes capable of lysing autologous tumor cells with cytokine-rich supernatants.
Cancer immunology, immunotherapy : CII 2002;51(8):440-8.
2002: Constantin N Baxevanis; Angelos D Gritzapis; Ourania E Tsitsilonis; HARALABOS L KATSOULAS; Michael Papamichail
HER-2/neu-derived peptide epitopes are also recognized by cytotoxic CD3(+)CD56(+) (natural killer T) lymphocytes.
International journal of cancer. Journal international du cancer 2002;98(6):864-72.
2002: Nike T Cacoullos; Angelos D Gritzapis; Athanasios E Tsitsilonis; Marinos L Tsiatas; Constantin N Baxevanis; Michael Papamichail
Efficacy of novel culture environments on the ex vivo expansion kinetics of cord blood progenitor cells.
Haematologica 2002;87(3):320-1.
2002: Sonia Perez; Panagiota A Sotiropoulou; Nectaria N Sotiriadou; Avgi Mamalaki; Angelos D Gritzapis; Hartmut Echner; Wolfgang Voelter; Graham Pawelec; Michael Papamichail; Constantin N Baxevanis
HER-2/neu-derived peptide 884-899 is expressed by human breast, colorectal and pancreatic adenocarcinomas and is recognized by in-vitro-induced specific CD4(+) T cell clones.
Cancer immunology, immunotherapy : CII 2002;50(11):615-24.
2001: R Sotiriadou; Sonia Perez; Angelos D Gritzapis; Panagiota A Sotiropoulou; Hartmut Echner; S Heinzel; Avgi Mamalaki; Graham Pawelec; Wolfgang Voelter; Constantin N Baxevanis; Michael Papamichail
Peptide HER2(776-788) represents a naturally processed broad MHC class II-restricted T cell epitope.
British journal of cancer 2001;85(10):1527-34.
2001: Marinos L Tsiatas; Angelos D Gritzapis; Nike T Cacoullos; SI Papadhimitriou; Constantin N Baxevanis; Michael Papamichail
A novel culture environment for generating mature human dentritic cells from peripheral blood CD14+ cells.
Anticancer research 2001;21(2A):1199-206.
2001: Stavroula Theodoropoulou; G Spanakos; Constantin N Baxevanis; M Economou; Angelos D Gritzapis; Michael Papamichail; Costas N Stefanis
Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients.
Schizophrenia research 2001;47(1):13-25.
2000: Ioannis F Voutsas; Constantin N Baxevanis; Angelos D Gritzapis; Ioannis Missitzis; G P Stathopoulos; G Archodakis; C Banis; Wolfgang Voelter; Michael Papamichail
Synergy between interleukin-2 and prothymosin alpha for the increased generation of cytotoxic T lymphocytes against autologous human carcinomas.
Cancer immunology, immunotherapy : CII 2000;49(8):449-58.
2000: Constantin N Baxevanis; Ioannis F Voutsas; Ourania E Tsitsilonis; Marinos L Tsiatas; Angelos D Gritzapis; Michael Papamichail
Compromised anti-tumor responses in tumor necrosis factor-alpha knockout mice.
European journal of immunology 2000;30(7):1957-66.
2000: Constantin N Baxevanis; Ioannis F Voutsas; Ourania E Tsitsilonis; Angelos D Gritzapis; R Sotiriadou; Michael Papamichail
Tumor-specific CD4+ T lymphocytes from cancer patients are required for optimal induction of cytotoxic T cells against the autologous tumor.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3902-12.
1999: Constantin N Baxevanis; G Spanakos; Ioannis F Voutsas; Angelos D Gritzapis; Ourania E Tsitsilonis; Avgi Mamalaki; Michael Papamichail
Increased generation of autologous tumor-reactive lymphocytes by anti-CD3 monoclonal antibody and prothymosin alpha.
Cancer immunology, immunotherapy : CII 1999;48(2-3):71-84.
1998: Constantin N Baxevanis; Ioannis F Voutsas; M H Soler; Angelos D Gritzapis; Ourania E Tsitsilonis; Stanka Stoeva; Wolfgang Voelter; P Arsenis; Michael Papamichail
Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity.
Immunopharmacology and immunotoxicology 1998;20(3):355-72.
1995: Nikolaos Papadopoulos; Angelos D Gritzapis; G V Dedoussis; G Spanakos; Constantin N Baxevanis; Michael Papamichail
Production and characterization of a monoclonal antibody against epirubicin.
Hybridoma 1995;14(6):593-6.
1995: Constantin N Baxevanis; Angelos D Gritzapis; G Spanakos; Ourania E Tsitsilonis; Michael Papamichail
Induction of tumor-specific T lymphocyte responses in vivo by prothymosin alpha.
Cancer immunology, immunotherapy : CII 1995;40(6):410-8.
1994: Nikolaos Papadopoulos; G V Dedoussis; G Spanakos; Angelos D Gritzapis; Constantin N Baxevanis; Michael Papamichail
An improved fluorescence assay for the determination of lymphocyte-mediated cytotoxicity using flow cytometry.
Journal of immunological methods 1994;177(1-2):101-11.
1994: Constantin N Baxevanis; G V Dedoussis; Angelos D Gritzapis; George P Stathopoulos; Michael Papamichail
Interleukin 1 beta synergises with interleukin 2 in the outgrowth of autologous tumour-reactive CD8+ effectors.
British journal of cancer 1994;70(4):625-30.
1994: Constantin N Baxevanis; G V Dedousis; Angelos D Gritzapis; Nikolaos Papadopoulos; P Arsenis; A Katsiyiannis; Michael Papamichail
On the role of monokines in the generation of nonspecific suppressor T cell activity in vitro.
Immunopharmacology and immunotoxicology 1994;16(2):225-45.
1994: Constantin N Baxevanis; Angelos D Gritzapis; G V Dedoussis; Nikolaos Papadopoulos; Orestes Tsolas; Michael Papamichail
Induction of lymphokine-activated killer activity in mice by prothymosin alpha.
Cancer immunology, immunotherapy : CII 1994;38(4):281-6.
1993: Constantin N Baxevanis; G J Reclos; Angelos D Gritzapis; G V Dedousis; I Missitzis; Michael Papamichail
Elevated prostaglandin E2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer.
Cancer 1993;72(2):491-501.
1993: Constantin N Baxevanis; G J Reclos; Angelos D Gritzapis; G V Dedousis; P Arsenis; A Katsiyiannis; P G Mitsis; N Tsavaris; Michael Papamichail
Comparison of immune parameters in patients with one or two primary malignant neoplasms.
Natural immunity 1993;12(1):41-9.
1992: E Anastasopoulos; G J Reclos; Constantin N Baxevanis; Angelos D Gritzapis; V Tsilivakos; N Panagiotopoulos; S Fotiou; I Missitzis; I Karydas; Michael Papamichail
Monocyte disorders associated with T cell defects in patients with solid tumors.
Anticancer research 1992;12(2):489-94.