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Jorge Iniguez-Lluhi

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Jimena Druker; Juan Gerez; Florian Holsboer; Jorge A Iniguez-Lluhi; Ana C Liberman; Marcelo Paez-Pereda; Theo Rein; María Antunica-Noguerol; Eduardo Arzt
RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity.
Sarmistha Mukherjee; Eric Bolton; Osvaldo Cruz-Rodríguez; Jorge A Iniguez-Lluhi
The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.
Theodora E Danciu; Jennifer E Fox; Sergey Chupreta; Osvaldo Cruz; Malcolm Whitman; Jorge A Iniguez-Lluhi
Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.

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All Publications

2013: Jimena Druker; Juan Gerez; Florian Holsboer; Jorge A Iniguez-Lluhi; Ana C Liberman; Marcelo Paez-Pereda; Theo Rein; María Antunica-Noguerol; Eduardo Arzt
RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity.
Molecular and cellular biology 2013;33(11):2116-27.
2012: Sarmistha Mukherjee; Eric Bolton; Osvaldo Cruz-Rodríguez; Jorge A Iniguez-Lluhi
The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.
The Journal of biological chemistry 2012;287(37):31195-206.
2012: Theodora E Danciu; Jennifer E Fox; Sergey Chupreta; Osvaldo Cruz; Malcolm Whitman; Jorge A Iniguez-Lluhi
Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
The Journal of biological chemistry 2012;287(22):18318-29.
2011: Paul M Jenkins; Tom K Kerppola; Arun Anantharam; Kristin L Arendt; Cynthia J L Carruthers; Ronald W Holz; Jorge A Iniguez-Lluhi; Jeremy C McIntyre; Michael Mark Alexander Sutton; Eileen D Vesely; Lian Zhang; Jeffrey R Martens
Subunit-dependent axonal trafficking of distinct alpha heteromeric potassium channel complexes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(37):13224-35.
2011: Natasha T Snider; Sujith V W Weerasinghe; Jorge A Iniguez-Lluhi; Harald Herrmann; M Bishr Omary
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.
The Journal of biological chemistry 2011;286(3):2273-84.
2009: Claudia Figueroa-Romero; Jorge A Iniguez-Lluhi; Julia Stadler; Chuang-Rung Chang; Damien Arnoult; Peter J Keller; Yu Hong; Craig Blackstone; Eva L Feldman
SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(11):3917-27.
2009: Sarmistha Mukherjee; Monzy Thomas; Nahid Dadgar; Andrew P Lieberman; Jorge A Iniguez-Lluhi
Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation.
The Journal of biological chemistry 2009;284(32):21296-306.
2009: Wei-Hsiung Yang; Joanne H Heaton; Holly Brevig; Sarmistha Mukherjee; Jorge A Iniguez-Lluhi; Gary Hammer
SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.
Molecular and cellular biology 2009;29(3):613-25.
2008: Sam R Holmstrom; Sergey Chupreta; Alex so; Jorge A Iniguez-Lluhi
SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX.
Molecular endocrinology (Baltimore, Md.) 2008;22(9):2061-75.
2008: Teresa I Ceseña; Tracy Xiao Cui; Lalitha Subramanian; Christina T Fulton; Jorge A Iniguez-Lluhi; Roland P S Kwok; Jessica Schwartz
Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription.
Molecular and cellular endocrinology 2008;289(1-2):94-101.
2007: Sergey Chupreta; Holly Brevig; Longchuan Bai; Juanita L Merchant; Jorge A Iniguez-Lluhi
Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89.
The Journal of biological chemistry 2007;282(50):36155-66.
2007: Dyke P McEwen; Sarah M Schumacher; Qiuju Li; Mark D Benson; Jorge A Iniguez-Lluhi; Kristin M Van Genderen; Jeffrey R Martens
Rab-GTPase-dependent endocytic recycling of Kv1.5 in atrial myocytes.
The Journal of biological chemistry 2007;282(40):29612-20.
2007: Chris R Evelyn; Susan M Wade; Qin Wang; Mei Wu; Jorge A Iniguez-Lluhi; Sofia D Merajver; Richard Neubig
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.
Molecular cancer therapeutics 2007;6(8):2249-60.
2007: Mark D Benson; Qiu-Ju Li; Katherine Kieckhafer; David Dudek; Matthew R Whorton; Roger K Sunahara; Jorge A Iniguez-Lluhi; Jeffrey R Martens
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1805-10.
2007: Teresa I Ceseña; Tracy Xiao Cui; Graciela Piwien-Pilipuk; Julianne Kaplani; Anda-Alexandra Calinescu; Jeffrey S Huo; Jorge A Iniguez-Lluhi; Roland P S Kwok; Jessica Schwartz
Multiple mechanisms of growth hormone-regulated gene transcription.
Molecular genetics and metabolism 2007;90(2):126-33.
2006: Jorge A Iniguez-Lluhi
For a healthy histone code, a little SUMO in the tail keeps the acetyl away.
ACS chemical biology 2006;1(4):204-6.
2005: Sergey Chupreta; Sam Holmstrom; Lalitha Subramanian; Jorge A Iniguez-Lluhi
A small conserved surface in SUMO is the critical structural determinant of its transcriptional inhibitory properties.
Molecular and cellular biology 2005;25(10):4272-82.
2003: Sam Holmstrom; Mary E Van Antwerp; Jorge A Iniguez-Lluhi
Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15758-63.
2003: Tae-Hwa Chun; Hiroshi Itoh; Lalitha Subramanian; Jorge A Iniguez-Lluhi; Kazuwa Nakao
Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.
Circulation research 2003;92(11):1201-8.
2003: Lalitha Subramanian; Mark D Benson; Jorge A Iniguez-Lluhi
A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.
The Journal of biological chemistry 2003;278(11):9134-41.
2002: Helmut Dotzlaw; Udo Moehren; Sigrun Mink; Andrew C B Cato; Jorge A Iniguez-Lluhi; Aria Baniahmad
The amino terminus of the human AR is target for corepressor action and antihormone agonism.
Molecular endocrinology (Baltimore, Md.) 2002;16(4):661-73.
2002: O Jameel Shah; Jorge A Iniguez-Lluhi; Angela Romanelli; Scot R Kimball; Leonard S Jefferson
The activated glucocorticoid receptor modulates presumptive autoregulation of ribosomal protein S6 protein kinase, p70 S6K.
The Journal of biological chemistry 2002;277(4):2525-33.
2000: Jorge A Iniguez-Lluhi; D Pearce
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
Molecular and cellular biology 2000;20(16):6040-50.
1999: Adam B Hittelman; Darya Burakov; Jorge A Iniguez-Lluhi; Leonard P Freedman; Michael J Garabedian
Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.
The EMBO journal 1999;18(19):5380-8.
1998: Keith R Yamamoto; Beatrice D Darimont; Richard L Wagner; Jorge A Iniguez-Lluhi
Building transcriptional regulatory complexes: signals and surfaces.
Cold Spring Harbor symposia on quantitative biology 1998;63():587-98.
1997: Jorge A Iniguez-Lluhi; D Y Lou; Keith R Yamamoto
Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus.
The Journal of biological chemistry 1997;272(7):4149-56.
1995: Mark A Wall; DE Coleman; Ethan Lee; Jorge A Iniguez-Lluhi; BA Posner; Alfred G Gilman; Stephen R Sprang
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.
Cell 1995;83(6):1047-58.
1994: E Reuveny; P A Slesinger; James Inglese; J M Morales; Jorge A Iniguez-Lluhi; R J Lefkowitz; Henry R Bourne; Yuh Nung Jan; Lily Yeh Jan
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.
Nature 1994;370(6485):143-6.
1994: James Inglese; Louis M Luttrell; Jorge A Iniguez-Lluhi; K Touhara; Walter J Koch; R J Lefkowitz
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3637-41.
1994: K Wickman; Jorge A Iniguez-Lluhi; P A Davenport; R Taussig; Grigory Krapivinsky; Maurine E Linder; Alfred G Gilman; D E Clapham
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel.
Nature 1994;368(6468):255-7.
1994: N Ueda; Jorge A Iniguez-Lluhi; Ethan Lee; A V Smrcka; J D Robishaw; Alfred G Gilman
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
The Journal of biological chemistry 1994;269(6):4388-95.
1993: R Taussig; Jorge A Iniguez-Lluhi; Alfred G Gilman
Inhibition of adenylyl cyclase by Gi alpha.
Science (New York, N.Y.) 1993;261(5118):218-21.
1993: Jorge A Iniguez-Lluhi; C Kleuss; Alfred G Gilman
The importance of G-protein beta lambda subunits.
Trends in cell biology 1993;3(7):230-6.
1992: Jorge A Iniguez-Lluhi; M I Simon; J D Robishaw; Alfred G Gilman
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma.
The Journal of biological chemistry 1992;267(32):23409-17.
1992: W J Tang; Jorge A Iniguez-Lluhi; S Mumby; Alfred G Gilman
Regulation of mammalian adenylyl cyclases by G-protein alpha and beta gamma subunits.
Cold Spring Harbor symposia on quantitative biology 1992;57():135-44.